Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Kangtao Wang, Shanshan Han, Li Liu, Lian Zhao, Ingrid Herr
Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at late stages, limiting treatment options and survival rates. Pyroptosis-related gene signatures hold promise as PDAC prognostic markers, but limited gene pools and small sample sizes hinder their utility. We aimed to enhance PDAC prognosis with a comprehensive multi-algorithm analysis. Using R, we employed natural language processing and latent Dirichlet allocation on PubMed publications to identify pyroptosis-related genes. We collected PDAC transcriptome data (n = 1273) from various databases, conducted a meta-analysis, and performed differential gene expression analysis on tumour and non-cancerous tissues...
January 15, 2024: Cancers
#22
JOURNAL ARTICLE
Ikrame Lazar, Ido Livneh, Aaron Ciechanover, Bertrand Fabre
Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes responsible for linking a transfer RNA (tRNA) with its cognate amino acid present in all the kingdoms of life. Besides their aminoacyl-tRNA synthetase activity, it was described that many of these enzymes can carry out non-canonical functions. They were shown to be involved in important biological processes such as metabolism, immunity, development, angiogenesis and tumorigenesis. In the present work, we provide evidence that tryptophanyl-tRNA synthetase might be involved in a negative feedback loop mitigating the expression of certain interferon-γ-induced genes...
January 17, 2024: Cells
#23
JOURNAL ARTICLE
Abazar Mahmoud Ismail, Bakri Mohammed Nour, Adam Dawoud Abakar, Babiker Saad Almugadam, Hisham N Altayb, Rania TagEsir Ahmed, Mubarak Elsaeed Mustafa Elkarsany
PURPOSE OF THE STUDY: The current study aimed to detect the frequency of normal and mutated APOL1 alleles in sickle cell disease (SCD) patients and test their relation with Microalbuminuria, Creatinine, Urea, Glomerular Filtration Rate (GFR), and Body Mass Index (BMI). PATIENTS AND METHODS: The study included 156 SCD subjects. Serum Creatinine (mg/dl) and Urea (mg/dl) as well as Microalbuminuria (mg/l) level were measured by using Biosystems kit (Biosystems, Barcelona, Spain) and Mindary BA88A semi-automated biochemistry analyzer...
September 29, 2023: Current Research in Translational Medicine
#24
JOURNAL ARTICLE
Somenath Datta, Brett M Antonio, Nathan H Zahler, Jonathan W Theile, Doug Krafte, Hengtao Zhang, Paul B Rosenberg, Alec B Chaves, Deborah M Muoio, Guofang Zhang, Daniel Silas, Guojie Li, Karen Soldano, Sarah Nystrom, Davis Ferreira, Sara E Miller, James R Bain, Michael J Muehlbauer, Olga Ilkayeva, Thomas C Becker, Hans-Ewald Hohmeier, Christopher B Newgard, Opeyemi A Olabisi
Two coding variants of apolipoprotein L1 (APOL1) called G1 and G2 explain much of the excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have been reported in experimental models, the proximal mechanism by which G1 and G2 cause kidney disease is poorly understood. Here, we leveraged three experimental models and a recently reported small molecule blocker of APOL1 protein, VX-147, to identify the upstream mechanism of G1-induced cytotoxicity. In HEK293 cells, we demonstrated that G1-mediated Na+ import/K+ efflux triggered activation of G protein-coupled receptor (GPCR)-IP3-mediated calcium release from the endoplasmic reticulum (ER), impaired mitochondrial ATP production, and impaired translation, which were all reversed by VX-147...
January 16, 2024: Journal of Clinical Investigation
#25
JOURNAL ARTICLE
Tristan McIntosh, Heidi Walsh, Kari Baldwin, Ana Iltis, Sumit Mohan, Deirdre Sawinski, Melody Goodman, James M DuBois
BACKGROUND: Apolipoprotein L1 (ApoL1) variants G1 and G2 are associated with a higher risk of kidney disease. ApoL1 risk variants are predominantly seen in individuals with sub-Saharan African ancestry. In most transplant centers, potential organ donors are being selectively genetically tested for ApoL1 risk variants. Transplant programs have highly variable ApoL1 testing practices and need guidance on essential ApoL1 clinical policy questions. METHODS: We conducted a Delphi consensus panel focused on ApoL1 clinical policy questions, including who gets tested, who decides whether testing occurs, how test results are shared, who receives test results, and how test results are used...
January 8, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#26
JOURNAL ARTICLE
Li-Da Chen, Li Lin, Ji-Zhi Chen, Yang Song, Wei-Liang Zhang, Huang-Yu Li, Jia-Min Luo, Xiao-Bin Zhang
BACKGROUND: Obstructive sleep apnea (OSA) is associated with increased risk of lung cancer mortality. Nevertheless, little is known about the underlying molecular mechanisms. This research aimed to investigate differentially expressed genes (DEGs) and explore their function in Lewis lung carcinoma (LLC)-bearing mice exposed to chronic intermittent hypoxia (CIH) by transcriptome sequencing. METHODS: Lung cancer tissues in LLC-bearing mice exposed to CIH or normoxia were subjected for transcriptome sequencing to examine DEGs...
January 5, 2024: BMC Cancer
#27
JOURNAL ARTICLE
Precil D Neves, Andreia Watanabe, Elieser H Watanabe, Amanda M Narcizo, Kelly Nunes, Antonio M Lerario, Frederico Moraes Ferreira, Lívia B Cavalcante, Janewit Wongboonsin, Denise M Malheiros, Lectícia B Jorge, Matthew G Sampsom, Irene L Noronha, Luiz F Onuchic
Collapsing glomerulopathy (CG) is most often associated with fast progression to kidney failure with an incidence apparently higher in Brazil than in other countries. However, the reason for this occurrence is unknown. To better understand this, we performed an integrated analysis of clinical, histological, therapeutic, causative genetic and genetic ancestry data in a highly genetically-admixed cohort of 70 children and adult patients with idiopathic CG (ICG). The disease onset occurred at 23 (17-31) years and approximately half of patients progressed to chronic kidney disease requiring kidney replacement therapy (CKD-KRT) 36 months after diagnosis...
December 22, 2023: Kidney International
#28
REVIEW
Joyita Bharati, Megan Kumar, Neil Kumar, Ashwani Malhotra, Pravin C Singhal
MicroRNAs (miRNAs) are noncoding small RNAs that regulate the protein expression of coding messenger RNAs. They are used as biomarkers to aid in diagnosing, prognosticating, and surveillance of diseases, especially solid cancers. MiR-193a was shown to be directly pathogenic in an experimental mouse model of focal segmental glomerulosclerosis (FSGS) during the last decade. Its specific binding and downregulation of Wilm's tumor-1 (WT-1), a transcription factor regulating podocyte phenotype, is documented. Also, miR-193a is a regulator switch causing the transdifferentiation of glomerular parietal epithelial cells to a podocyte phenotype in in vitro study...
December 4, 2023: Biomolecules
#29
JOURNAL ARTICLE
Jelena Mustra Rakic, Clive R Pullinger, Erin L Van Blarigan, Irina Movsesyan, Eveline Oestreicher Stock, Mary J Malloy, John P Kane
BACKGROUND: African American smokers have 2.5 times higher risk for stroke compared with nonsmokers (higher than other races). About 50% of the African American population carry 1 or 2 genetic variants (G1 and G2; rare in other races) of the apolipoprotein L1 gene ( APOL1 ). Studies showed these variants may be associated with stroke. However, the role of the APOL1 risk variants in tobacco-related stroke is unknown. METHODS AND RESULTS: In a cross-sectional study, we examined whether APOL1 risk variants modified the relationship between tobacco smoking and stroke prevalence in 513 African American adults recruited at University of California, San Francisco...
December 12, 2023: Journal of the American Heart Association
#30
Rostislav Skitchenko, Zora Modrusan, Alexander Loboda, Jeffrey B Kopp, Cheryl A Winkler, Alexey Sergushichev, Namrata Gupta, Christine Stevens, Mark J Daly, Andrey Shaw, Mykyta Artomov
Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome with an annual incidence in the United States in African-Americans compared to European-Americans of 24 cases and 5 cases per million, respectively. Among glomerular diseases in Europe and Latin-America, FSGS was the second most frequent diagnosis, and in Asia the fifth. We expand previous efforts in understanding genetics of FSGS by performing a case-control study involving ethnically-diverse groups FSGS cases (726) and a pool of controls (13,994), using panel sequencing of approximately 2,500 podocyte-expressed genes...
November 20, 2023: medRxiv
#31
JOURNAL ARTICLE
Laurence Lecordier, Paul Heo, Jonas H Graversen, Dorle Hennig, Maria Kløjgaard Skytthe, Alexandre Cornet d'Elzius, Frédéric Pincet, David Pérez-Morga, Etienne Pays
Apolipoproteins L1 and L3 (APOLs) are associated at the Golgi with the membrane fission factors phosphatidylinositol 4-kinase-IIIB (PI4KB) and non-muscular myosin 2A. Either APOL1 C-terminal truncation (APOL1Δ) or APOL3 deletion (APOL3-KO [knockout]) reduces PI4KB activity and triggers actomyosin reorganization. We report that APOL3, but not APOL1, controls PI4KB activity through interaction with PI4KB and neuronal calcium sensor-1 or calneuron-1. Both APOLs are present in Golgi-derived autophagy-related protein 9A vesicles, which are involved in PI4KB trafficking...
December 1, 2023: Cell Reports
#32
JOURNAL ARTICLE
Yask Gupta, David J Friedman, Michelle T McNulty, Atlas Khan, Brandon Lane, Chen Wang, Juntao Ke, Gina Jin, Benjamin Wooden, Andrea L Knob, Tze Y Lim, Gerald B Appel, Kinsie Huggins, Lili Liu, Adele Mitrotti, Megan C Stangl, Andrew Bomback, Rik Westland, Monica Bodria, Maddalena Marasa, Ning Shang, David J Cohen, Russell J Crew, William Morello, Pietro Canetta, Jai Radhakrishnan, Jeremiah Martino, Qingxue Liu, Wendy K Chung, Angelica Espinoza, Yuan Luo, Wei-Qi Wei, Qiping Feng, Chunhua Weng, Yilu Fang, Iftikhar J Kullo, Mohammadreza Naderian, Nita Limdi, Marguerite R Irvin, Hemant Tiwari, Sumit Mohan, Maya Rao, Geoffrey K Dube, Ninad S Chaudhary, Orlando M Gutiérrez, Suzanne E Judd, Mary Cushman, Leslie A Lange, Ethan M Lange, Daniel L Bivona, Miguel Verbitsky, Cheryl A Winkler, Jeffrey B Kopp, Dominick Santoriello, Ibrahim Batal, Sérgio Veloso Brant Pinheiro, Eduardo Araújo Oliveira, Ana Cristina Simoes E Silva, Isabella Pisani, Enrico Fiaccadori, Fangming Lin, Loreto Gesualdo, Antonio Amoroso, Gian Marco Ghiggeri, Vivette D D'Agati, Riccardo Magistroni, Eimear E Kenny, Ruth J F Loos, Giovanni Montini, Friedhelm Hildebrandt, Dirk S Paul, Slavé Petrovski, David B Goldstein, Matthias Kretzler, Rasheed Gbadegesin, Ali G Gharavi, Krzysztof Kiryluk, Matthew G Sampson, Martin R Pollak, Simone Sanna-Cherchi
African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play a major role in this disparity. While 13% of African Americans carry the high-risk recessive genotypes, only a fraction of these individuals develops FSGS or kidney failure, indicating the involvement of additional disease modifiers. Here, we show that the presence of the APOL1 p.N264K missense variant, when co-inherited with the G2 APOL1 risk allele, substantially reduces the penetrance of the G1G2 and G2G2 high-risk genotypes by rendering these genotypes low-risk...
November 30, 2023: Nature Communications
#33
JOURNAL ARTICLE
Luke V Rasmussen, Akansha H Agrawal, Elisa J Gordon
No abstract text is available yet for this article.
November 1, 2023: Kidney360
#34
REVIEW
George Vasquez-Rios, Marina De Cos, Kirk N Campbell
Apolipoprotein L1 ( APOL1 ) high-risk variants confer an increased risk for the development and progression of kidney disease among individuals of recent African ancestry. Over the past several years, significant progress has been made in understanding the pathogenesis of APOL1- mediated kidney diseases (AMKD), including genetic regulation, environmental interactions, immunomodulatory, proinflammatory and apoptotic signaling processes, as well as the complex role of APOL1 as an ion channel. Collectively, these findings have paved the way for novel therapeutic strategies to mitigate APOL1 -mediated kidney injury...
November 2023: KI Reports
#35
JOURNAL ARTICLE
Xiang-Kun Wang, Yu-Xiang Guo, Miao Wang, Xu-Dong Zhang, Zhong-Yuan Liu, Mao-Sen Wang, Kai Luo, Shuai Huang, Ren-Feng Li
Hepatocellular carcinoma (HCC) is a lethal malignancy worldwide with an increasing number of new cases each year. Apolipoprotein (APOL) isoforms have been explored for their associations with HCC.The GSE14520 cohort was used for training data; The Cancer Genome Atlas (TCGA) database was used for validated data. Diagnostic, prognostic significance and mechanisms were explored using these cohorts. Risk score models and nomograms were constructed using prognosis-related isoforms and clinical factors for survival prediction...
November 28, 2023: Scientific Reports
#36
JOURNAL ARTICLE
Jun-Yi Zhu, Jin-Gu Lee, Yulong Fu, Joyce van de Leemput, Patricio E Ray, Zhe Han
People of African ancestry carrying the APOL1 risk alleles (RA) G1 or G2 are at high risk of developing kidney diseases through not fully understood mechanisms that impair the function of podocytes. It is also not clear whether the APOL1-G1 and G2 RA affect these cells through similar mechanisms. Previously, we developed transgenic Drosophila fly lines expressing either the human APOL1 reference allele (G0) or APOL1-G1 specifically in nephrocytes, the cells homologous to mammalian podocytes. We found that nephrocytes that expressed the APOL1-G1 RA displayed accelerated cell death, in a manner similar to cultured human podocytes and APOL1 transgenic mouse models...
November 16, 2023: Disease Models & Mechanisms
#37
JOURNAL ARTICLE
Ha My T Vy, Steven G Coca, Ashwin Sawant, Ankit Sakhuja, Orlando M Gutierrez, Richard Cooper, Ruth J F Loos, Carol R Horowitz, Ron Do, Girish N Nadkarni
No abstract text is available yet for this article.
November 14, 2023: Clinical Journal of the American Society of Nephrology: CJASN
#38
JOURNAL ARTICLE
Jane K Nguyen, Zhenzhen Wu, Jose Agudelo, Leal C Herlitz, Aaron W Miller, Leslie A Bruggeman
No abstract text is available yet for this article.
November 6, 2023: Kidney360
#39
JOURNAL ARTICLE
Jin-Gu Lee, Yulong Fu, Jun-Yi Zhu, Pei Wen, Joyce van de Leemput, Patricio E Ray, Zhe Han
BACKGROUND: People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD remain elusive, hindering the development of potential treatments. RESULTS: Using a Drosophila genetic modifier screen, we found that SNARE proteins (Syx7, Ykt6, and Syb) play an important role in preventing APOL1 cytotoxicity...
November 4, 2023: Cell & Bioscience
#40
JOURNAL ARTICLE
Miriam Paz-Barba, Amadeo Muñoz Garcia, Twan J J de Winter, Natascha de Graaf, Maarten van Agen, Elisa van der Sar, Ferdy Lambregtse, Lizanne Daleman, Arno van der Slik, Arnaud Zaldumbide, Eelco J P de Koning, Françoise Carlotti
AIMS/HYPOTHESIS: Inflammation induces beta cell dysfunction and demise but underlying molecular mechanisms remain unclear. The apolipoprotein L (APOL) family of genes has been associated with innate immunity and apoptosis in non-pancreatic cell types, but also with metabolic syndrome and type 2 diabetes mellitus. Here, we hypothesised that APOL genes play a role in inflammation-induced beta cell damage. METHODS: We used single-cell transcriptomics datasets of primary human pancreatic islet cells to study the expression of APOL genes upon specific stress conditions...
November 4, 2023: Diabetologia
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
