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https://www.readbyqxmd.com/read/29049665/reoperation-for-mitral-paravalvular-leak-a-single-centre-experience-with-200-patients
#1
Sameh M Said, Hartzell V Schaff, Kevin L Greason, Alberto Pochettino, Richard C Daly, Joseph A Dearani
OBJECTIVES: Paravalvular leak (PVL) is a major cause of morbidity and mortality after mitral valve replacement. Risk factors and data on long-term surgical outcomes are lacking. METHODS: Between January 1995 and December 2012, 206 [118 males (57%)] patients underwent reoperation due to mitral PVL. Mean age was 64 ± 11 years. Haemolytic anaemia was present in 85 (41%) patients, while 137 (67%) patients were in New York Heart Association Class III or IV. Baseline creatinine was above 1...
July 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29048916/reduced-magnetism-in-core-shell-magnetite-mof-composites
#2
Sameh K Elsaidi, Michael Sinnwell, Debasis Banerjee, Arun Devaraj, Ravi K Kukkadapu, Timothy Droubay, Zimin Nie, Libor Kovarik, Murugesan Vijayakumar, Sandeep Manandhar, Manjula I Nandasiri, B Peter McGrail, Praveen K Thallapally
The magnetic susceptibility of core-shell microspheres was found to decline after the growth of a metal-organic framework (MOF) shell on a synthesized magnetite (Fe3O4) core. Detailed structural analysis of the core-shell particles using scanning electron microscopy (SEM), transmission electron microscopy (TEM), atom probe tomography (ATP), and 57Fe-Mössbauer spectroscopy suggest the distribution of MOF precursors inside the magnetic core resulted in the oxidation of the iron oxide core.
October 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/29039818/the-role-of-b-cell-targeting-in-chronic-graft-versus-host-disease
#3
REVIEW
Ruben Rhoades, Sameh Gaballa
Chronic graft-versus-host disease (cGVHD) is a leading cause of late morbidity and mortality following allogeneic stem cell transplantation. Current therapies, including corticosteroids and calcineurin inhibitors, are only effective in roughly 50% of cases; therefore, new treatment strategies are under investigation. What was previously felt to be a T cell disease has more recently been shown to involve activation of both T and B cells, as well as a number of cytokines. With a better understanding of its pathophysiology have come more expansive preclinical and clinical trials, many focused on B cell signaling...
October 17, 2017: Biomedicines
https://www.readbyqxmd.com/read/29029030/outcomes-of-surgery-for-infective-endocarditis-a-single-centre-experience-of-801-patients
#4
Sameh M Said, Zaid M Abdelsattar, Hartzell V Schaff, Kevin L Greason, Richard C Daly, Alberto Pochettino, Lyle D Joyce, Joseph A Dearani
OBJECTIVES: Infective endocarditis (IE) remains a life-threatening disease, despite the improvement in diagnostic and therapeutic measures. We reviewed our outcomes for all adults who underwent surgery for endocarditis at our centre. METHODS: Between January 1995 and December 2013, 801 patients [586 men (73%)] underwent surgery for IE. Mean age was 60 ± 14.7 years. Native endocarditis (NE) was present in 372 patients (46%), and 379 (47%) patients had active IE...
October 3, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28994864/tunisian-adult-s-hodgkin-lymphoma-study-group
#5
Raihane Ben Lakhal, Sondos Hdiji, Yosra Ben Youssef, Mohamed Adnène Laariri, Sami Zriba, Nabil Toumi, Amina Mokrani, Faten Ezzaier, Salwa Ladb, Hatem Frikha, Taha Mesai, Hanen Ben Salah, Sameh Tebra, Jamel Daoued, Noureddine Bouaouina, Monji Maalej, Mounir Frikha, Slim Ben Ahmed, Amel Mezlini, Tarek Ben Othmen, Fehmi Msaddek, Abderrahim Khelif, Moez Elloumi, Balkis Meddeb
The Tunisian adult's Hodgkin lymphoma (HL) Study Group was created in 1999. It aimed to improve the management of this curable hematologic malignancy by standardizing the diagnosis, assessment of disease, treatment management and therapeutic evaluation in different Tunisian centers (Hematology, oncology and radiotherapy).Since 1998, four versions of the prospective national protocol for treating adult Hodgkin lymphoma have succeeded (MDH99, MDH2002, MDH2008, MDH2015). Each version was based on the results of the previous version and analyzed according to new data from the literature...
November 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28991344/combined-oral-and-topical-beta-blockers-for-the-treatment-of-early-proliferative-superficial-periocular-infantile-capillary-hemangioma
#6
Hatem M Marey, Hesham F Elmazar, Sameh S Mandour, Hany A Khairy
PURPOSE: To evaluate the safety and efficacy of combined oral and topical beta blockers for the treatment of superficial periocular infantile hemangioma at the early proliferative stage. METHODS: This was a randomized, controlled comparison trial involving 25 patients. Patients were randomly enrolled into two groups: the topical and systemic treatment and systemic treatment only groups. The topical and systemic treatment group was treated with oral propranolol (1 mg/kg per day initially, increased to 2 mg/kg per day gradually in 2 weeks) and timolol maleate 0...
October 9, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28989245/plants-natural-products-as-alternative-promising-anti-candida-drugs
#7
REVIEW
Sameh Soliman, Dina Alnajdy, Ali A El-Keblawy, Kareem A Mosa, Ghalia Khoder, Ayman M Noreddin
Candida is a serious life-threatening pathogen, particularly with immunocompromised patients. Candida infections are considered as a major cause of morbidity and mortality in a broad range of immunocompromised patients. Candida infections are common in hospitalized patients and elderly people. The difficulty to eradicate Candida infections is owing to its unique switch between yeast and hyphae forms and more likely to biofilm formations that render resistance to antifungal therapy. Plants are known sources of natural medicines...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28987034/impact-of-patient-characteristics-and-treatment-procedures-on-hospitalisation-cost-and-length-of-stay-in-japanese-patients-with-influenza-a-structural-equation-modelling-approach
#8
Rosarin Sruamsiri, Sameh Ferchichi, Aurélien Jamotte, Mondher Toumi, Hiroshi Kubo, Jörg Mahlich
OBJECTIVES: Little is known about the economic burden of influenza-related hospitalisations in Japan. This study sought to identify the factors that contribute to the total health care costs associated with hospitalisations due to influenza in the Japanese population. STUDY DESIGN: A retrospective cross-sectional database analysis study. METHODS: A structural equation modelling approach was used to analyse a nationwide Japanese hospital claims data...
October 7, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28986089/anterior-deflected-urinary-stream
#9
Wisam Abbas, Mark Woodward, Mohamed Sameh Shalaby
We present a case of anterior deflected urinary stream (ADUS) secondary to meatal shelf with no dysfunctional voiding symptoms (DV). The video illustrates the presentation, operative management and literature review. Meatal deformity in girls has been described in association with DV. Hoebeke et al. highlighted the strong correlation between meatal abnormality and non-neurogenic bladder dysfunction in girls. They demonstrated that girls with ADUS had more severe dysfunction on urodynamics. Klijn et al. prospectively evaluated the effect of surgical meatal correction in girls with ADUS...
September 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28982558/transcatheter-and-surgical-management-of%C3%A2-mitral%C3%A2-paravalvular-leak-long-term-outcomes
#10
Mohamad Alkhouli, Charanjit S Rihal, Chad J Zack, Mackram F Eleid, Elad Maor, Mohammad Sarraf, Allison K Cabalka, Guy S Reeder, Donald J Hagler, Joseph F Maalouf, Vuyisile T Nkomo, Hartzell V Schaff, Sameh M Said
OBJECTIVES: The aim of this study was to report the use trends and immediate and long-term outcomes of a large cohort of patients who underwent redo surgery or transcatheter repair of paravalvular leaks (PVLs) at a tertiary referral center. BACKGROUND: Percutaneous treatment of mitral PVL has emerged as an alternative to surgical treatment in high-risk surgical candidates. There are limited data on the utilization trends, safety, and efficacy of both procedures in the management of mitral PVL...
October 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28982556/early-outcomes-of-percutaneous-transvenous-transseptal-transcatheter-valve-implantation-in-failed-bioprosthetic-mitral-valves-ring-annuloplasty-and%C3%A2-severe-mitral-annular-calcification
#11
Mackram F Eleid, Brian K Whisenant, Allison K Cabalka, Mathew R Williams, Mohammed Nejjari, David Attias, Neil Fam, Nicholas Amoroso, Thomas A Foley, Peter M Pollak, Oluseun O Alli, Sorin V Pislaru, Sameh M Said, Joseph A Dearani, Charanjit S Rihal
OBJECTIVES: The aim of this study was to examine 1-year outcomes of transseptal balloon-expandable transcatheter heart valve implantation in failed mitral bioprosthesis, ring annuloplasty, and mitral annular calcification (MAC). BACKGROUND: Immediate outcomes following transseptal mitral valve implantation in failed bioprostheses are favorable, but data on subsequent outcomes are lacking. METHODS: Percutaneous transseptal implantation of balloon-expandable transcatheter heart valves was performed in 87 patients with degenerated mitral bioprostheses (valve in valve [VIV]) (n = 60), previous ring annuloplasty (valve in ring) (n = 15), and severe MAC (valve in MAC) (n = 12)...
October 9, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28977823/intraductal-cisplatin-treatment-in-a-brca-associated-breast-cancer-mouse-model-attenuates-tumor-development-but-leads-to-systemic-tumors-in-aged-female-mice
#12
Jolien S de Groot, Paul J van Diest, Miranda van Amersfoort, Eva J Vlug, Xiaojuan Pan, Natalie D Ter Hoeve, Hilde Rosing, Jos H Beijnen, Sameh A Youssef, Alain de Bruin, Jos Jonkers, Elsken van der Wall, Patrick W B Derksen
BRCA deficiency predisposes to the development of invasive breast cancer. In BRCA mutation carriers this risk can increase up to 80%. Currently, bilateral prophylactic mastectomy and prophylactic bilateral salpingo-oophorectomy are the only preventive, albeit radical invasive strategies to prevent breast cancer in BRCA mutation carriers. An alternative non-invasive way to prevent BRCA1-associated breast cancer may be local prophylactic treatment via the nipple. Using a non-invasive intraductal (ID) preclinical intervention strategy, we explored the use of combined cisplatin and poly (ADP)-ribose polymerase 1 (PARP1) inhibition to prevent the development of hereditary breast cancer...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28958670/limited-sampling-strategy-for-the-estimation-of-mycophenolic-acid-area-under-the-curve-in-tunisian-renal-transplant-patients
#13
Emna Gaies, Mouna Ben Sassi, Hanene El Jebari, Nadia Jebabli, Rim Charfi, Ichraf Chokri, Issam Salouage, Anis Klouz, Sameh Trabelsi
Mycophenolate mofetil is a prodrug widely used in renal transplantation to prevent organ rejection. It is hydrolyzed to its active compound mycophenolic acid (MPA). MPA area under the curve (AUC0-12h) is considered the best pharmacokinetic parameter for the estimation of MPA exposition and for prediction of rejection. MPA-AUC requires several blood samples, making it impractical for clinical practice. Therefore, development of a limited sampling strategy (LSS) to estimate MPA AUC0-12h using three blood samples is very helpful for MPA individual dose adjustment...
September 22, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28950331/direct-transatrial-implantation-of-balloon-expandable-valve-for-mitral-stenosis-with-severe-annular-calcifications-early-experience-and-lessons-learned
#14
Abdallah El Sabbagh, Mackram F Eleid, Thomas A Foley, Mohammed A Al-Hijji, Richard C Daly, Charanjit S Rihal, Sameh M Said
OBJECTIVES: Patients with symptomatic severe mitral annular calcification present a therapeutic challenge. Direct transatrial implantation of SAPIEN valve has emerged as an alternative to surgical mitral valve (MV) replacement for high-risk surgical candidates. METHODS: This series includes 6 consecutive patients with symptomatic severe mitral annular calcification deemed to be at high risk for standard surgery. All patients underwent direct transatrial implantation of balloon-expandable SAPIEN valve in the mitral position...
July 26, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28947323/one-trocar-needlescopic-assisted-inguinal-hernia-repair-in-children-a-novel-technique
#15
Rafik Shalaby, Ibrahim Elsayaad, Omar Alsamahy, Refaat Ibrahem, Adham El-Saied, Maged Ismail, Abdelmoniem Shamseldin, Sameh Shehata, Mohamad Magid
BACKGROUND: Inguinal hernia repair using a percutaneous internal ring suturing technique is an effective alternative technique to conventional laparoscopic hernia repair. It is one of the most commonly used approaches for laparoscopic hernia repair in children. However, most percutaneous techniques have utilized extracorporeal knotting of the suture and burying the knot subcutaneously. This approach has several drawbacks. The aim of this study is to present a modified technique for single cannula needlescopic assisted hernia repair in children...
August 31, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28944185/transapical-approach-for-myectomy-in-hypertrophic-cardiomyopathy
#16
REVIEW
Kunal D Kotkar, Sameh M Said, Hartzell V Schaff
No abstract text is available yet for this article.
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944179/hypertrophic-cardiomyopathy-in-children
#17
Arman Arghami, Joseph A Dearani, Sameh M Said, Patrick W O'Leary, Hartzell V Schaff
Hypertrophic cardiomyopathy (HCM) occurs in 1 of 500 adults and is considered to be one of the most common causes of death in young people under 35 years of age. Children with HCM are usually asymptomatic and the overall annual mortality beyond the first year of life is 1%. Septal myectomy is safe and effective in children with obstructive HCM and published data shows improved late survival compared to untreated HCM. Patient selection and surgical expertise remain critical components to ensuring successful outcomes of septal myectomy, particularly when considering prophylactic myectomy in a seemingly asymptomatic patient...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944173/hypertrophic-obstructive-cardiomyopathy-the-mayo-clinic-experience
#18
Kunal D Kotkar, Sameh M Said, Joseph A Dearani, Hartzell V Schaff
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease characterized by left ventricular hypertrophy in the absence of other etiologies. Clinical presentation may vary from asymptomatic to sudden cardiac death. Medical treatment is the first-line therapy for symptomatic patients. Extended left ventricular septal myectomy is the procedure of choice if medical treatment is unsuccessful or intolerable. MAYO CLINIC EXPERIENCE: More than 3,000 patients have had septal myectomy for HCM at the Mayo Clinic (MN, USA) from 1993 to 2016...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28941199/capped-mesoporous-silica-nanoparticles-for-the-selective-and-sensitive-detection-of-cyanide
#19
Sameh El Sayed, Maurizio Licchelli, Ramón Martínez-Máñez, Félix Sancenón
The development of easy and affordable methods for the detection of cyanide is of great significance due to the high toxicity of this anion and the potential risks associated with its pollution. Herein, optical detection of cyanide in water has been achieved by using a hybrid organic-inorganic nanomaterial. Mesoporous silica nanoparticles were loaded with [Ru(bipy)3 ](2+) , functionalized with macrocyclic nickel(II) complex subunits, and capped with a sterically hindering anion (hexametaphosphate). Cyanide selectively induces demetallation of nickel(II) complexes and the removal of capping anions from the silica surface, allowing the release of the dye and the consequent increase in fluorescence intensity...
September 22, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28936612/endotracheal-intubation-ultrasound-guided-versus-fiberscope-in-patients-with-cervical-spine-immobilization
#20
Moustafa Abdelaziz Moustafa, Emad A Arida, Ola M Zanaty, Sameh Fathy El-Tamboly
BACKGROUND: Ultrasound has growing applications in airway management during anesthesia. The aim of the present study was to evaluate the feasibility of real-time ultrasound-guided tracheal intubation in patients with cervical spine immobilization relative to fiberscope-guided tracheal intubation. PATIENTS AND METHODS: This randomized controlled study was carried out on 266 adult patients who have a rigid neck collar in place for cervical spine immobilization and were randomly allocated into two equal groups...
September 21, 2017: Journal of Anesthesia
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