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https://www.readbyqxmd.com/read/29674046/development-of-a-chromatographic-method-with-multi-criteria-decision-making-design-for-simultaneous-determination-of-nifedipine-and-atenolol-in-content-uniformity-testing
#1
Sameh Ahmed, Abdulmalik Alqurshi, Abdel-Maaboud Ismail Mohamed
A new robust and reliable high-performance liquid chromatography (HPLC) method with multi-criteria decision making (MCDM) approach was developed to allow simultaneous quantification of atenolol (ATN) and nifedipine (NFD) in content uniformity testing. Felodipine (FLD) was used as an internal standard (I.S.) in this study. A novel marriage between a new interactive response optimizer and a HPLC method was suggested for multiple response optimizations of target responses. An interactive response optimizer was used as a decision and prediction tool for the optimal settings of target responses, according to specified criteria, based on Derringer's desirability...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29672037/correction-to-discovery-structure-activity-relationship-and-binding-mode-of-an-imidazo-1-2-a-pyridine-series-of-autotaxin-inhibitors
#2
Agnès Joncour, Nicolas Desroy, Christopher Housseman, Xavier Bock, Natacha Bienvenu, Laëtitia Cherel, Virginie Labeguere, Christophe Peixoto, Denis Annoot, Luce Lepissier, Jörg Heiermann, Willem Jan Hengeveld, Gregor Pilzak, Alain Monjardet, Emanuelle Wakselman, Veronique Roncoroni, Sandrine Le Tallec, René Galien, Christelle David, Nele Vandervoort, Thierry Christophe, Katja Conrath, Mia Jans, Alexandre Wohlkonig, Sameh Soror, Jan Steyaert, Robert Touitou, Damien Fleury, Lionel Vercheval, Patrick Mollat, Nicolas Triballeau, Ellen van der Aar, Reginald Brys, Bertrand Heckmann
No abstract text is available yet for this article.
April 19, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29660667/high-performance-thin-layer-chromatographic-methods-for-the-determination-of-febuxostat-and-febuxostat-diclofenac-combination-in-human-plasma
#3
Fawzi A El-Yazbi, Omayma A Amin, Eman I El-Kimary, Essam F Khamis, Sameh E Younis
Two simple, sensitive and specific high-performance thin-layer chromatographic (HPTLC) methods were developed for the determination of febuxostat (FEB) individually, and simultaneously with diclofenac (DIC) in human plasma. Method A presents the first HPTLC-ultraviolet attempt for FEB determination in human plasma. FEB was separated from endogenous plasma components (at hRF  = 70) with ethyl acetate-methanol-water (9:2:1, v/v) mixture as mobile phase and quantified by densitometry at its λmax (315 nm)...
April 10, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29657681/outcomes-of-isolated-antenatal-hydronephrosis-at-first-year-of-life
#4
Mutaz Orabi, Sameh Abozaid, Bahauddin Sallout, Amani Abu Shaheen, Humariya Heena, Abdulrahman Al Matary
Objectives: To compare the grade of hydronephrosis between the antenatal and first postnatal ultrasound (US) and their clinical outcomes. Methods: This retrospective study included all cases of isolated hydronephrosis detected by antenatal US from August 2005 to February 2011. Hydronephrosis was classified based on the standard criteria into mild, moderate, or severe. Cases associated with other major congenital anomalies were excluded. All patients were followed-up postnatally and outcomes available were analyzed at one year of age...
March 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29652911/pharmacogenetic-landscape-of-metabolic-syndrome-components-drug-response-in-tunisia-and-comparison-with-worldwide-populations
#5
Haifa Jmel, Lilia Romdhane, Yosra Ben Halima, Meriem Hechmi, Chokri Naouali, Hamza Dallali, Yosr Hamdi, Jingxuan Shan, Abdelmajid Abid, Henda Jamoussi, Sameh Trabelsi, Lotfi Chouchane, Donata Luiselli, Sonia Abdelhak, Rym Kefi
Genetic variation is an important determinant affecting either drug response or susceptibility to adverse drug reactions. Several studies have highlighted the importance of ethnicity in influencing drug response variability that should be considered during drug development. Our objective is to characterize the genetic variability of some pharmacogenes involved in the response to drugs used for the treatment of Metabolic Syndrome (MetS) in Tunisia and to compare our results to the worldwide populations. A set of 135 Tunisians was genotyped using the Affymetrix Chip 6...
2018: PloS One
https://www.readbyqxmd.com/read/29652673/inflammation-and-coronary-artery-disease-from-pathophysiology-to-canakinumab-anti-inflammatory-thrombosis-outcomes-study-cantos
#6
Mahboob Ali, Sameh Girgis, Atif Hassan, Steven Rudick, Richard C Becker
The worldwide prevalence of cardiovascular disease in general and atherosclerotic coronary artery disease in particular is a health and economic concern of unparalleled proportion. Despite a long history of astute observations beginning in 1575 made by Fallopius, followed by those of von Rokatansky, Virchow, Osler, and Ross, and incremental knowledge of the pathobiology of atherosclerosis to include varying stages of inflammation, response to internally and externally mediated vascular injury, and impaired homeostasis, gaps in the field's understanding persist...
April 12, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29629668/using-dna-barcoding-to-detect-adulteration-in-different-herbal-plant-based-products-in-the-united-arab-emirates-proof-of-concept-and-validation
#7
Kareem A Mosa, Sameh Soliman, Ali El-Keblawy, Muna Abdalla Ali, Hessa Ali Hassan, Aysha Ali Bin Tamim, Moza Mohamed Al-Ali
Commercially available herbal and medicinal plants-based products are susceptible to substitution or contamination with other unlabeled or undesired materials. This will reduce the quality of the product, and may lead to intoxication and allergy. DNA Barcoding is a molecular technology that allows the identification of plant materials at the species level, by sequencing short stretches of standardized gene sequences from nuclear or organelle genome in an easy, rapid, accurate and cost-effective manner. The aim of this research is to apply DNA barcoding to investigate the authenticity of commercially available herbal and medicinal plant-based products within the UAE markets...
April 8, 2018: Recent Patents on Food, Nutrition & Agriculture
https://www.readbyqxmd.com/read/29628586/postoperative-cardiac-surgery-outcomes-in-a-statin-native-population
#8
Sameh Aboulnaga, Ahmed Mahfouz, Hesham A Ewila, Alejandro Kohn Tuli, Rajvir Singh, Amr S Omar, Abdulaziz Al Khualifi
Background: Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications. Design: This was a retrospective, descriptive, single-center study. Settings: We analyzed morbidity after cardiac surgery as well as the outcome related to statin therapy in a tertiary cardiac center. Patients: A total of 202 consecutive patients were enrolled over 1 year after cardiac surgery...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29623013/human-leukocyte-antigens-drb1-03-is-associated-with-systemic-lupus-erythematosus-and-anti-ssb-production-in-south-tunisia
#9
Hend Hachicha, Arwa Kammoun, Nadia Mahfoudh, Sameh Marzouk, Sawsan Feki, Raouia Fakhfakh, Hajer Fourati, Samy Haddouk, Faten Frikha, Lilia Gaddour, Feiza Hakim, Zouheir Bahloul, Hafedh Makni, Hatem Masmoudi
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease with various presentations. This variation is due to the interaction of hormonal, environmental, and genetic factors. Associations between human leukocyte antigens and SLE have long been recognized in different ethnic populations and have been suggested to represent the most important association. Objectives: The objectives of this paper were to determine susceptibility and protection human leukocyte antigens (HLA) Class II markers for SLE and to highlight, for the first time, associations between HLA alleles and clinical and serological features in South Tunisia...
January 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29619150/effects-of-mothers-knowledge-and-coping-strategies-on-the-glycemic-control-of-their-diabetic-children-in-egypt
#10
Eman Mohamed Mahfouz, Nashwa Nabil Kamal, Eman Sameh Mohammed, Sara Ahmed Refaei
Background: This study aimed to examine the relationship between mothers' knowledge related to treatment management of type 1 diabetes (T1D), with perceptions of coping with diabetes-related stress and to examine the relationship between children's metabolic control and maternal coping. A cross-sectional study was done among ninety-two mothers of T1D children. Methods: Data were collected using a structured questionnaire, Ways of coping questionnaire (WCQ), and Diabetes Knowledge questionnaire-24 (DKQ-24)...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29611086/resveratrol-as-an-effective-adjuvant-therapy-in-the-management-of-rheumatoid-arthritis-a-clinical-study
#11
Hani M Khojah, Sameh Ahmed, Mahran S Abdel-Rahman, Eman H Elhakeim
Resveratrol (RSV), a naturally occurring polyphenol, has been found to have potent antioxidant, anti-inflammatory, and anticancer effects. Recently, RSV was reported as a new potential agent to suppress inflammation of collagen-induced arthritis in a mouse model. Nevertheless, the clinical benefits of RSV in the management of rheumatoid arthritis (RA) were not studied. This randomized controlled clinical trial aims to shed some light on the therapeutic benefits of RSV in the treatment of RA in patients with different stages of the disease activity...
April 3, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29604150/neurophysiological-study-of-critical-illness-polyneuropathy-and-myopathy-in-mechanically-ventilated-children-additional-aspect-into-pediatric-critical-illness-comorbidities
#12
Ahmed Thabet Mahmoud, Maha A M Tawfik, Sameh Abdallah Abd El Naby, Wafaa Moustafa M Abo El Fotoh, Nagwan Yossery Saleh, Nahla M Said Abd El Hady
BACKGROUND: Critical illness polyneuropathy and myopathy (CIP/CIM) is being increasingly recognized as a significant clinical problem in critically ill children especially who have spent long periods in the intensive care unit. So we aimed to determine the frequency of CIP/CIM among mechanically ventilated children and to analyze the associated risk factors and drawbacks frequently encountered in this cohort. METHODS: The study included 105 patients admitted to the pediatric intensive care unit and underwent mechanical ventilation for ≥7 days...
March 31, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29603009/endoscopic-pilonidal-sinus-treatment-a-systematic-review-and-meta-analysis
#13
REVIEW
Sameh Hany Emile, Hossam Elfeki, Mostafa Shalaby, Ahmad Sakr, Valentina Giaccaglia, Pierpaolo Sileri, Steven D Wexner
BACKGROUND: Sacrococcygeal pilonidal disease (SPD) is a common surgical condition for which a multitude of surgical treatments have been described. The present review aimed to evaluate the efficacy and safety of a novel endoscopic procedure for the treatment of SPD. METHODS: An organized literature search was conducted. Electronic databases including PubMed/Medline, Scopus, Embase, and Cochrane library were searched for articles that assessed the endoscopic treatment for SPD...
March 30, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29602153/lymphocytic-choriomeningitis-virus-infection-of-dendritic-cells-interferes-with-tlr-induced-il-12-il-23-cytokine-production-in-an-il-10-independent-manner
#14
Nor Fazila Che Mat, Sarah Siddiqui, Divya Mehta, Kyle Seaver, Andra Banete, Torki Alothaimeen, Katrina Gee, Sameh Basta
Dendritic cells produce IL-12 and IL-23 in response to viral and bacterial infection and these cytokines are responsible for successful pathogen clearance. How sequential viral and bacterial infections affect the production of IL-12 and IL-23 is currently not known. Our study demonstrates that in dendritic cells infected with Lymphocytic choriomeningitis virus (LCMV), TLR activation with bacterial PAMPs resulted in reduced IL-12 and IL-23 expression compared to non-infected cells. Furthermore, expression of other proinflammatory cytokines, TNF-α and IL-6, were not inhibited under these conditions...
March 26, 2018: Cytokine
https://www.readbyqxmd.com/read/29588809/evolution-of-transanal-total-mesorectal-excision-for-rectal-cancer-from-top-to-bottom
#15
REVIEW
Sameh Hany Emile, F Borja de Lacy, Deborah Susan Keller, Beatriz Martin-Perez, Sadir Alrawi, Antonio M Lacy, Manish Chand
The gold standard for curative treatment of locally advanced rectal cancer involves radical resection with a total mesorectal excision (TME). TME is the most effective treatment strategy to reduce local recurrence and improve survival outcomes regardless of the surgical platform used. However, there are associated morbidities, functional consequences, and quality of life (QoL) issues associated with TME; these risks must be considered during the modern-day multidisciplinary treatment for rectal cancer. This has led to the development of new surgical techniques to improve patient, oncologic, and QoL outcomes...
March 27, 2018: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29587970/association-between-cataract-progression-and-ischemia-modified-albumin-in-relation-to-oxidant-antioxidant-profiles-in-the-serum-aqueous-humor-and-lens
#16
Hesham M Elmazar, Ibrahim Elmadbouh, Sameh S Mandour, Gehad M Al Ariny, Asmaa M Ibrahim
PURPOSE: To evaluate the levels of ischemia-modified albumin (IMA) in relation to oxidant-antioxidant profiles in the serum, aqueous, and lens in cataract patients. SETTING: Department of Ophthalmology, Menoufia University, Shebin El Kom, Menoufia, Egypt. DESIGN: Prospective case series. METHODS: Patients were divided into 2 groups. The cataract (study) group comprised patients with senile cataract and the control group, age- and sex-matched healthy persons...
February 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29573600/epidural-angiolipoma-a-rare-cause-of-spinal-cord-compression
#17
Mouna Rkhami, Mohamed Ali Kedous, Sameh Achoura, Alia Zehani, Kamel Bahri, Ihsen Zammel
INTRODUCTION: Angiolipomas are benign, slow growing lesions, almost always located subcutaneously in the trunc or limbs. They are composed of mature lipocytes admixed with abnormal blood vessels. Spinal epidural angiolipoma are rare accounting for approximately 0.14-1.2% of all spinal axis tumors and 2-3% of epidural spinal tumors. PRESENTATION OF CASE: We report the case of a 65 years-old-woman, presenting with complete paraplegia installed since 7 months. Magnetic resonance imaging (MRI) showed an epidural dorsal fatty mass...
March 15, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29571912/mechanical-properties-of-glide-path-preparation-instruments-with-different-pitch-lengths
#18
Dana Al Raeesi, Sang Won Kwak, Jung-Hong Ha, Sameh Sulaiman, Rashid El Abed, Hyeon-Cheol Kim
INTRODUCTION: This study compared the effects of pitch length on the torsional resistance and cyclic fatigue resistance of glide path preparation instruments. METHODS: G-File (G1 and G2; Micro-Mega, Besançon, France) and new generation G-File (NG1 and NG2, Micro-Mega) instruments were compared to evaluate the effects of the shorter pitch of the latter (25% shorter than G-File). G1 and NG1 have a #12 tip size, whereas G2 and NG2 have a #17 tip size. All the files have the same taper of 3%...
March 20, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29565695/long-term-outcome-of-internal-limiting-membrane-peeling-with-and-without-foveal-sparing-in-myopic-foveoschisis
#19
Mohammed Mamdouh Elwan, Ayman Elsayed Abd Elghafar, Sherein Mahmoud Hagras, Waleed Ali Abou Samra, Sameh Mohamed Saleh
PURPOSE: To compare between vitrectomy with internal limiting membrane peeling over the whole macula and preservation of the epi-foveal internal limiting membrane in myopic foveoschisis. PATIENTS AND METHODS: A prospective controlled non- randomized comparative study included patients with myopic foveoschisis recruited between 2013 and 2017. Patients were allocated into two groups: group A included patients who underwent vitrectomy with complete macular internal limiting membrane peeling and group B included those who underwent preservation of the epi-foveal membrane...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29565057/nanoparticle-wrapping-at-small-non-spherical-vesicles-curvatures-at-play
#20
Qingfen Yu, Sameh Othman, Sabyasachi Dasgupta, Thorsten Auth, Gerhard Gompper
Nanoparticles in biological systems encounter lipid-bilayer membranes as barriers. They interact with plasma membranes, membranous organelles, such as the endoplasmic reticulum and the Golgi apparatus, the nucleus, and intracellular and extracellular vesicles, such as autophagosomes, lysosomes, and exosomes. Extracellular vesicles have recently attracted particular attention, as they are involved in the transmission of biological signals and as regulators for biological processes. For example, exosomes, small vesicles containing proteins, mRNA, and miRNA, that are released by cells into the extracellular environment, have been suggested to participate in tumor metastasis...
March 22, 2018: Nanoscale
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