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https://www.readbyqxmd.com/read/28068792/arthroscopic-reduction-and-internal-fixation-arif-of-a-comminuted-posterior-talar-body-fracture
#1
Rishin Kadakia, Jeff Konopka, Tristan Rodik, Samra Ahmed, Sameh A Labib
: The talus is the second most common fractured tarsal bone. While their incidence may be low, talus fractures are severe injuries that can lead to long-term disability and pain. Displaced talar body fractures are typically treated through an open approach with the aim of obtaining anatomic reduction and stable fixation. There are several case reports in the literature demonstrating successful management of talus fractures arthroscopically. An arthroscopic approach minimizes soft tissue trauma, which can help decrease postoperative wound complications and infections...
January 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28057408/dithiocarbamates-effectively-inhibit-the-%C3%AE-carbonic-anhydrase-from-the-dandruff-producing-fungus-malassezia-globosa
#2
Daniela Vullo, Sonia Del Prete, Alessio Nocentini, Sameh M Osman, Zeid AlOthman, Clemente Capasso, Murat Bozdag, Fabrizio Carta, Paola Gratteri, Claudiu T Supuran
A series of dithiocarbamates (DTCs) was investigated for the inhibition of the β-class carbonic anhydrase (CAs, EC 4.2.1.1) from the fungal parasite Malassezia globosa, MgCA, a validated anti-dandruff drug target. These DTCs incorporate various scaffold, among which those of N,N-dimethylaminoethylenediamine, the aminoalcohols with 3-5 carbon atoms in their molecule, 3-amino-quinuclidine, piperidine, morpholine and piperazine derivatives, as well as phenethylamine and its 4-sulfamoylated derivative. Several DTCs resulted more effective in inhibiting MgCA compared to the standard sulfonamide drug acetazolamide (KI of 74μM), with KIs ranging between 383 and 6235nM...
December 27, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28056780/kinmap-a-web-based-tool-for-interactive-navigation-through-human-kinome-data
#3
Sameh Eid, Samo Turk, Andrea Volkamer, Friedrich Rippmann, Simone Fulle
BACKGROUND: Annotations of the phylogenetic tree of the human kinome is an intuitive way to visualize compound profiling data, structural features of kinases or functional relationships within this important class of proteins. The increasing volume and complexity of kinase-related data underlines the need for a tool that enables complex queries pertaining to kinase disease involvement and potential therapeutic uses of kinase inhibitors. RESULTS: Here, we present KinMap, a user-friendly online tool that facilitates the interactive navigation through kinase knowledge by linking biochemical, structural, and disease association data to the human kinome tree...
January 5, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28052408/relapse-risk-and-survival-in-patients-with-flt3-acute-myeloid-leukemia-undergoing-stem-cell-transplantation
#4
Sameh Gaballa, Rima Saliba, Betul Oran, Jonathan E Brammer, Julianne Chen, Gabriela Rondon, Amin M Alousi, Partow Kebriaei, David Marin, Uday R Popat, Borje S Andersson, Elizabeth J Shpall, Elias Jabbour, Naval Daver, Michael Andreeff, Farhad Ravandi, Jorge Cortes, Keyur Patel, Richard E Champlin, Stefan O Ciurea
In patients with AML with FMS-like tyrosine kinase 3 (FLT3) mutations, the significance of minimal residual disease (MRD) detected by PCR before allogeneic stem cell transplantation (SCT) on outcomes after transplant remains unclear. We identified 200 patients with FLT3-AML who underwent SCT at our institution. Disease status at transplant was: first or second complete remission (CR1/CR2, n=119), high-risk CR (third or subsequent CR, marrow hypoplasia, or incomplete count recovery) (CR-HR, n=31), and morphological evidence of active disease (AD, n=50)...
January 4, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28052241/modeling-dynamics-and-function-of-bone-marrow-cells-in-mouse-liver-regeneration
#5
Elisa Pedone, Vlad-Aris Olteanu, Lucia Marucci, Maria Isabel Muñoz-Martin, Sameh A Youssef, Alain de Bruin, Maria Pia Cosma
In rodents and humans, the liver can efficiently restore its mass after hepatectomy. This is largely attributed to the proliferation and cell cycle re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate into the liver after resection. Here, we find that a block of BMC recruitment into the liver severely impairs its regeneration after the surgery. Mobilized hematopoietic stem and progenitor cells (HSPCs) in the resected liver can fuse with hepatocytes, and the hybrids proliferate earlier than the hepatocytes...
January 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28025002/sulfonamide-inhibition-profile-of-the-%C3%AE-carbonic-anhydrase-identified-in-the-genome-of-the-pathogenic-bacterium-burkholderia-pseudomallei-the-etiological-agent-responsible-of-melioidosis
#6
Sonia Del Prete, Daniela Vullo, Pietro Di Fonzo, Sameh M Osman, Zeid AlOthman, William A Donald, Claudiu T Supuran, Clemente Capasso
A new γ-carbonic anhydrase (CA, EC 4.1.1.1) was cloned and characterized kinetically in the genome of the bacterial pathogen Burkholderia pseudomallei, the etiological agent of melioidosis, an endemic disease of tropical and sub-tropical regions of the world. The catalytic activity of this new enzyme, BpsCAγ, is significant with a kcat of 5.3×10(5)s(-1) and kcat/Km of 2.5×10(7)M(-1)×s(-1) for the physiologic CO2 hydration reaction. The inhibition constant value for this enzyme for 39 sulfonamide inhibitors was obtained...
December 12, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28012928/ameliorative-effect-of-parsley-oil-on-cisplatin-induced-hepato-cardiotoxicity-a-biochemical-histopathological-and-immunohistochemical-study
#7
Suhair A Abdellatief, Azza A A Galal, Sameh M Farouk, Mohamed M Abdel-Daim
Cisplatin (cis-diamminedichloroplatinum, CDDP) is an effective DNA alkylating agent used in the treatment of different types of tumors; however, its clinical use is associated with hepato-cardiotoxicity. The current study was designed to assess the potential protective effect of parsley oil (PO) against CDDP-induced hepato-cardiotoxicity. For this purpose, 25 adult male rats were assigned into five groups, each containing five animals. Group I (control) was administered saline solution. Group II was administered PO at a dosage of 0...
December 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28011329/functional-role-of-ccl5-rantes-for-hcc-progression-during-chronic-liver-disease
#8
Antje Mohs, Nadine Kuttkat, Johanna Reißing, Henning Wolfgang Zimmermann, Roland Sonntag, Amanda Proudfoot, Sameh A Youssef, Alain de Bruin, Francisco Javier Cubero, Christian Trautwein
BACKGROUND & AIMS: During liver inflammation, triggering fibrogenesis and carcinogenesis immune cells play a pivotal role. In the present study we investigated the role of CCL5 in human and in murine models of chronic liver inflammation leading to HCC development. METHODS: CCL5 expression and its receptors were studied in well-defined patients with chronic liver disease (CLD) and in two murine inflammation based HCC models. The role of CCL5 in inflammation, fibrosis, tumor initiation and progression was analyzed in different cell populations of NEMO(Δhepa)/CCL5(-/-) animals and after bone marrow transplantation (BMT)...
December 20, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28003863/resolving-contributions-of-oxygen-consuming-and-ros-generating-enzymes-at-the-synapse
#9
Engy A Abdel-Rahman, Ali M Mahmoud, Abdullah Aaliya, Yasmine Radwan, Basma Yasseen, Abdelrahman Al-Okda, Ahmed Atwa, Eslam Elhanafy, Moaaz Habashy, Sameh S Ali
Disruption of cellular redox homeostasis is implicated in a wide variety of pathologic conditions and aging. A fundamental factor that dictates such balance is the ratio between mitochondria-mediated complete oxygen reduction into water and incomplete reduction into superoxide radical by mitochondria and NADPH oxidase (NOX) enzymatic activity. Here we determined mitochondrial as well as NOX-dependent rates of oxygen consumption in parallel with H2O2 generation in freshly isolated synaptosomes using high resolution respirometry combined with fluorescence or electrochemical sensory...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27998799/phospholipid-complex-enriched-micelles-a-novel-drug-delivery-approach-for-promoting-the-antidiabetic-effect-of-repaglinide
#10
Ahmed Alaa Kassem, Sameh Hosam Abd El-Alim, Mona Basha, Abeer Salama
To enhance the oral antidiabetic effect of repaglinide (RG), a newly emerging approach, based on the combination of phospholipid complexation and micelle techniques, was employed. Repaglinide-phospholipid complex (RG-PLC) was prepared by the solvent-evaporation method then characterized using Differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR) and X-ray powder diffraction (XPRD). The results revealed obvious disappearance of the characteristic peaks of the prepared RG-PLCs confirming the formation of drug-phospholipid complex...
December 17, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27990170/evaluation-of-wound-healing-properties-of-grape-seed-sesame-and-fenugreek-oils
#11
Dorsaf Moalla Rekik, Sameh Ben Khedir, Kamilia Ksouda Moalla, Naziha Grati Kammoun, Tarek Rebai, Zouheir Sahnoun
Background. Medicinal plants have proved at all times to be a powerful remedy for health care. Accordingly, grape seed, sesame, and fenugreek extracted oils with pharmacological properties are investigated as wound treatments. This study assesses the potential of our oils for healing wounds induced on rats. Methods. Phytochemical analyses of oils have involved: quality value, polyphenol, chlorophylls, carotene, and fatty acids. Antibacterial activity was carried out. Antioxidant activity was evaluated: the scavenging effect on DPPH radicals, the reducing power, and β-carotene discoloration...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27977576/outcome-of-primary-trabeculotomy-ab-interno-trabectome-surgery-in-patients-with-steroid-induced-glaucoma
#12
Philip Ngai, Grace Kim, Garrick Chak, Ken Lin, Masahiro Maeda, Sameh Mosaed
To determine the efficacy and safety of Trabectome surgery on patients with steroid response, ranging from ocular hypertension refractory to maximal medical therapy to the development of steroid-induced glaucoma.A nonrandomized, nonblinded, retrospective study of 20 subjects with steroid response was conducted. All 20 eyes underwent Trabectome surgery alone. Nine subjects had steroid response with unremarkable visual field, 3 had mild steroid-induced glaucoma, and 8 had advanced steroid-induced glaucoma. Outcome measures included intraocular pressure (IOP), number of glaucoma medications, need for secondary glaucoma surgery, and steroid regimen...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27970023/tct-644-transcatheter-balloon-expandable-sapien-valve-implantation-using-transatrial-approach-in-patients-with-mitral-stenosis-and-severe-mitral-annular-calcification
#13
Abdallah El Sabbagh, Thomas Foley, Chet Rihal, Mackram Eleid, Sameh Said
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27966949/profiling-prediction-of-kinase-inhibitors-toward-the-virtual-assay
#14
Benjamin Merget, Samo Turk, Sameh Eid, Friedrich Rippmann, Simone Fulle
Kinome-wide screening would have the advantage of providing structure-activity relationships against hundreds of targets simultaneously. Here, we report the generation of ligand-based activity prediction models for over 280 kinases by employing Machine Learning methods on an extensive data set of proprietary bioactivity data combined with open data. High quality (AUC > 0.7) was achieved for ∼200 kinases by (1) combining open with proprietary data, (2) choosing Random Forest over alternative tested Machine Learning methods, and (3) balancing the training data sets...
December 14, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27960552/chemical-composition-phytochemical-constituents-antioxidant-and-anti-inflammatory-activities-of-urtica-urens-l-leaves
#15
Massara Mzid, Sameh Ben Khedir, Sana Bardaa, Zouheir Sahnoun, Tarek Rebai
OBJECTIVE: The aim of this study was to investigate the chemical composition and antioxidant properties of Urtica urens L.(Uu) as well as its anti-inflammatory effect on carrageenan (CARR)-induced paw oedema in rats. METHODS: The leaves were extracted using ethanol (EtOH) and water. The extracts were analysed for proximate composition and antioxidant activity using standard chemical analysis methods. RESULTS: The proximate analysis showed that Uu leaves contained appreciable percentages of dry mass, ashes, carbohydrates, proteins, lipids, sugars, anthocyanin, carotenoid and fibre...
December 14, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27956194/enhancement-of-8-methoxypsoralen-topical-delivery-via-nanosized-niosomal-vesicles-formulation-development-in-vitro-and-in-vivo-evaluation-of-skin-deposition
#16
Ahmed Alaa Kassem, Sameh Hosam Abd El-Alim, Marwa Hasanein Asfour
The aim of the present study is to enhance the skin penetration and deposition of 8-methoxypsoraln (8-MOP) via niosomal vesicles to increase its local efficacy and safety. 8-MOP niosomes were prepared by the thin film hydration method using Span 60 or Span 40 along with cholesterol at five different molar ratios. The obtained vesicles revealed high entrapment efficiencies (83.04-89.90%) with nanometric vesicle diameters (111.1-198.8nm) of monodisperse distribution (PDI=0.145-0.216), zeta potential values <-48...
December 9, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27943547/abdominal-rectopexy-for-the-treatment-of-internal-rectal-prolapse-a-systematic-review-and-meta-analysis
#17
REVIEW
S H Emile, H A Elfeki, M Youssef, M Farid, S D Wexner
AIM: Internal rectal prolapse (IRP) is a unique functional disorder that presents with a wide spectrum of clinical symptoms, including constipation and/or faecal incontinence (FI). The present review aims to analyse the results of trials evaluating the role of abdominal rectopexy in the treatment of IRP with regard to regarding functional and technical outcomes. METHOD: A systematic review of the literature for the role of abdominal rectopexy in patients with IRP was conducted...
January 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27943520/evaluation-of-anatomical-and-functional-results-of-overlapping-anal-sphincter-repair-with-or-without-the-injection-of-bone-marrow-aspirate-concentrate-a-case-control-study
#18
W W Khafagy, M M El-Said, W M Thabet, S E-S Aref, W Omar, S H Emile, H Elfeki, M S El-Ghonemy, M T El-Shobaky
AIM: Overlapping anal sphincter repair (OASR) is used for treatment of faecal incontinence due to an external anal sphincter (EAS) defect; however, it is not the optimal treatment as its functional results tend to deteriorate significantly with time. The present study aimed to evaluate the effect of local injection of bone marrow aspirate concentrate (BMAC) on the outcome of OASR. METHOD: We compared a prospective group of 20 patients with EAS defect who were managed with OASR and BMAC injection (group I) with a historical control group of an equal number of patients managed with OASR alone (group II)...
January 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27942518/lost-wire-ultrasound-can-find-it-for-you
#19
Faisal Siddiqui, Santosh Nepal, Susanti Ie, Sameh Aziz
The use of ultrasound (US) in clinical practice is becoming increasingly popular. This unique case highlights the importance of this technology in management of a complication arising from a central line placement in an intensive care unit (ICU).
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27942145/effect-of-proprioception-cross-training-on-repositioning-accuracy-and-balance-among-healthy-individuals
#20
Tarek Mohamed El-Gohary, Osama Ahmed Khaled, Sameh R Ibrahim, Abdullah M Alshenqiti, Mahmoud I Ibrahim
[Purpose] To investigate possible cross effects of proprioception training on proprioception repositioning accuracy of the knee joint and on balance in healthy subjects. [Subjects and Methods] Sixty healthy college students and faculty members from faculty of physical therapy, Cairo University were recruited to participate. Participants were randomly assigned to training group (n=30) and control group (n=30). The training group received proprioceptive training program only for the dominant leg while the control group did not receive any kind of training...
November 2016: Journal of Physical Therapy Science
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