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https://www.readbyqxmd.com/read/29457493/the-impact-of-vitamin-d-supplementation-on-attention-deficit-hyperactivity-disorder-in-children
#1
Hatem Hamed Elshorbagy, Naglaa Fathy Barseem, Waleed Elsayed Abdelghani, Hany Abdelaziz Ibrahim Suliman, Ashraf Hamed Al-Shokary, Sameh Elsayed Abdulsamea, Akram Elshafey Elsadek, Yehia Hamed Abdel Maksoud, Dalia Mohamed Abd El-Hassib Nour El Din
BACKGROUND: The role of nutrients and dietary factors in attention-deficit hyperactivity disorder (ADHD) remains unclear. OBJECTIVES: The primary objective was to evaluate the serum vitamin D level in children with a diagnosis of ADHD. The secondary objective was to detect the effect of vitamin D supplementation on cognitive function in those with vitamin D deficiency. METHODS: A total of 50 children with ADHD and 40 healthy controls were included in the study...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29454075/the-g-protein-coupled-p2y-6-receptor-promotes-colorectal-cancer-tumorigenesis-by-inhibiting-apoptosis
#2
Morgane Placet, Guillaume Arguin, Caroline M Molle, Jean-Philippe Babeu, Christine Jones, Julie C Carrier, Bernand Robaye, Sameh Geha, Francois Boudreau, Fernand-Pierre Gendron
Colorectal tumors are immersed in an array of tumor-promoting factors including extracellular nucleotides such as uridine 5'‑diphosphate (UDP). UDP is the endogenous agonist of the G protein-coupled P2Y 6 receptor (P2Y 6 R), which may contribute to the formation of a tumor-promoting microenvironment by coordinating resistance to apoptosis. Colorectal cancer (CRC) was chemically induced in P2ry6 knockout (P2ry6 -/- ) mice using azoxymethane and dextran sulfate sodium challenges. Mice were euthanatized and their tumor load determined...
February 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29452998/resection-of-intrathoracic-paraganglioma-with-and-without-cardiopulmonary-bypass
#3
Carmelina Gurrieri, James J Butz, Toby N Weingarten, Irina Bancos, William F Young, Stephen D Cassivi, Sameh M Said, Travis J McKenzie, David W Barbara, Juraj Sprung
BACKGROUND: Intrathoracic paragangliomas (PGLs) are rare tumors. Approximately 50% originate from and around cardiac structures. METHODS: A retrospective review was made of the perioperative course of patients with intrathoracic PGL resection from 2000 through 2015 at Mayo Clinic in Rochester, Minnesota. RESULTS: Twenty-two patients underwent PGL resection. Sixteen patients (73%) had functioning tumors (11, noradrenergic; 4, mixed noradrenergic and dopaminergic; 1, dopaminergic)...
February 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29448402/nonreciprocity-in-the-dynamics-of-coupled-oscillators-with-nonlinearity-asymmetry-and-scale-hierarchy
#4
Keegan J Moore, Jonathan Bunyan, Sameh Tawfick, Oleg V Gendelman, Shuangbao Li, Michael Leamy, Alexander F Vakakis
In linear time-invariant dynamical and acoustical systems, reciprocity holds by the Onsager-Casimir principle of microscopic reversibility, and this can be broken only by odd external biases, nonlinearities, or time-dependent properties. A concept is proposed in this work for breaking dynamic reciprocity based on irreversible nonlinear energy transfers from large to small scales in a system with nonlinear hierarchical internal structure, asymmetry, and intentional strong stiffness nonlinearity. The resulting nonreciprocal large-to-small scale energy transfers mimic analogous nonlinear energy transfer cascades that occur in nature (e...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29440002/effect-of-donor-characteristics-on-haploidentical-transplantation-with-posttransplantation-cyclophosphamide
#5
Shannon R McCurdy, Mei-Jie Zhang, Andrew St Martin, Monzr M Al Malki, Asad Bashey, Sameh Gaballa, Daniel A Keesler, Mehdi Hamadani, Maxim Norkin, Miguel-Angel Perales, Ran Reshef, Vanderson Rocha, Rizwan Romee, Melhem Solh, Alvaro Urbano-Ispizua, Edmund K Waller, Ephraim J Fuchs, Mary Eapen
We studied the association between non-HLA donor characteristics (age, sex, donor-recipient relationship, blood group [ABO] match, and cytomegalovirus [CMV] serostatus) and transplant outcomes after T-cell-replete HLA-haploidentical transplantation using posttransplantation cyclophosphamide (PT-Cy) in 928 adults with hematologic malignancy transplanted between 2008 and 2015. Siblings (n = 358) and offspring (n = 450) were the predominant donors, with only 120 patients having received grafts from parents. Although mortality risks were higher with donors aged 30 years or older (hazard ratio, 1...
February 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/29433871/rotational-gluteal-flap-versus-modified-limberg-flap-in-treatment-of-sacrococcygeal-pilonidal-disease
#6
Mahmoud Abdelnaby, Sameh Hany Emile, Mohamed El-Said, Ahmed AbdelMawla, Hesham Elgendy, Ahmed Sakr, Mostafa Shalaby
BACKGROUND: Sacrococcygeal pilonidal disease (SPND) is a common surgical condition with a multitude of surgical treatments. The aim of this study was to compare the outcome of modified Limberg flap (MLF) and that of rotational gluteal flap (RGF) in treatment of SPND. MATERIALS AND METHODS: This was a retrospective case-controlled study involving adult patients of both genders who were treated with either MLF or RGF for SPND. The main outcomes of the study were the recurrence of SPND, complications, operation time, hospital stay, time of healing, time to return to daily activities, and cosmetic outcomes...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29431896/on-taking-the-sting-out-of-immune-activation
#7
REVIEW
Andra Banete, Kyle Seaver, Devyani Bakshi, Katrina Gee, Sameh Basta
Nearly a decade ago, an endoplasmic reticulum (ER) adaptor protein called stimulator of interferon genes (STING) was found to be critical in the induction of type I IFN production in response to DNA virus infection. STING functions by sensing cytoplasmic DNA and activates key transcription factors, including IFN regulatory factor (IRF)-3 and IRF7, to initiate type I IFN expression. Type I IFNs are vital in immunity against viral infections and can influence cancer cell proliferation, migration, and apoptosis...
February 12, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29427386/diffusion-mri-monitoring-of-specific-structures-in-the-irradiated-rat-brain
#8
Julie Constanzo, Matthieu Dumont, Réjean Lebel, Luc Tremblay, Kevin Whittingstall, Laurence Masson-Côté, Sameh Geha, Philippe Sarret, Martin Lepage, Benoit Paquette, Maxime Descoteaux
PURPOSE: The analysis of biological and mesoscopic structures properties by diffusion MRI (dMRI) in brain after radiation therapy remains challenging. In our study, we described the consequences associated with an unwanted dose to healthy tissue, assessing radiation-induced brain alterations of living rats with dMRI compared to histopathology and behavioral assays. METHODS: The right primary motor cortex M1 of the rat brain was targeted by stereotactic radiosurgery with a mean radiation dose of 41 Gy...
February 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29425464/renin-angiotensin-system-inhibition-ameliorates-ccl4-induced-liver-fibrosis-in-mice-through-the-inactivation-of-nuclear-transcription-factor-kappa-b
#9
Sameh Saber, Amr A A Mahmoud, Noha Said Helal, Eman El-Ahwany, Rasha Abdelghany
Therapeutic interventions for liver fibrosis are still limited due to the complicated molecular pathogenesis. Renin-angiotensin system (RAS) seems to contribute to the development of hepatic fibrosis. Therefore, we aimed to examine the effect of RAS inhibition on CCl4-induced liver fibrosis. Mice were treated with silymarin (30 mg kg-1), perindopril (1 mg kg-1), fosinopril (2 mg kg-1), or losartan (10 mg kg-1). The administration RAS inhibitors improved liver histology and decreased protein expression of alpha smooth muscle actin (α-SMA) and hepatic content of hydroxyproline...
February 9, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29421510/relationship-between-chemotypic-and-genetic-diversity-of-natural-populations-of-artemisia-herba-alba-asso-growing-wild-in-tunisia
#10
Faten Younsi, Najoua Rahali, Sameh Mehdi, Mohamed Boussaid, Chokri Messaoud
A total of 80 individuals collected from eight populations growing wild in different geographic zones were considered to assess the intraspecific variability of essential oil composition, genetic diversity and population structure of Artemisia herba-alba. The essential oil composition varied significantly between populations. Essential oil profiles were classified into four chemotypes (trans-sabinyl acetate, α-thujone/trans-sabinyl acetate, camphor and α-thujone/camphor/β-thujone). Despite significant correlation between the amount of some essential oil compounds and a set of climatic data, the global chemical divergence among populations was not related to their bioclimatic and geographic appurtenances...
February 1, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29421006/mechanism-for-temporal-changes-in-exercise-capacity-after-fontan-palliation-role-of-doppler-echocardiography
#11
Alexander Egbe, Arooj R Khan, William R Miranda, Naser M Ammash, Carole A Warnes, Sameh S Said, Nathaniel W Taggart, Emmanuel Akintoye, Gruschen R Veldtman, Heidi M Connolly
BACKGROUND: The objective was to better understand Doppler hemodynamics and exercise capacity in patients with Fontan palliation by delineating the hemodynamic mechanism for temporal changes in their peak oxygen consumption (V̇o2). METHODS: We performed a retrospective review of adult Fontan patients with systemic left ventricle (LV) who underwent serial transthoracic echocardiograms (TTE) and cardiopulmonary exercise tests (CPET) at Mayo Clinic in 2000-2015. TTE and CPET data were used (1) to determine agreement between V̇o2 and Doppler-derived LV function indices (eg, stroke volume index [SVI] and cardiac index [CI]) and (2) to determine agreement between temporal changes in peak V̇o2 and LV function indices...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29415032/mechanical-and-phytochemical-protection-mechanisms-of-calligonum-comosum-in-arid-deserts
#12
Sameh Soliman, Mohammad G Mohammad, Ali A El-Keblawy, Hany Omar, Mohamed Abouleish, Mohamed Madkour, Attiat Elnaggar, Racha M Hosni
Unlike animals, plants are sessile organisms, lacking circulating antibodies and specialized immune cells and are exposed to various harsh environmental conditions that make them at risk of being attacked by different pathogens and herbivores. Plants produce chemo-signals to respond to the surroundings and be able to distinguish between harmless and harmful signals. In this study, the production of phytochemicals as plant signaling mechanisms and their defensive roles in disease resistance and repelling herbivores are examined in Calligonum comosum...
2018: PloS One
https://www.readbyqxmd.com/read/29409618/outcome-of-tricuspid-valve-surgery-in-the-presence-of-permanent-pacemaker
#13
Nishant Saran, Sameh M Said, Hartzell V Schaff, Simon Maltais, John M Stulak, Kevin L Greason, Richard C Daly, Alberto Pochettino, Katherine S King, Joseph A Dearani
OBJECTIVES: Given the paucity of available literature, we sought to evaluate the mechanisms of tricuspid regurgitation and the outcomes of tricuspid valve surgery in the presence of permanent pacemakers. METHODS: We retrospectively reviewed the records of 622 adult patients who underwent tricuspid valve surgery in the presence of permanent pacemakers between January 1993 and December 2013. Those with prosthetic tricuspid valve or tricuspid valve endocarditis and those undergoing concomitant heart transplant were excluded (n = 23)...
December 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29408417/structural-functional-and-biological-properties-of-potato-peel-oligosaccharides
#14
Khawla Ben Jeddou, Fatma Bouaziz, Claire Boisset Helbert, Oumèma Nouri-Ellouz, Sameh Maktouf, Semia Ellouz-Chaabouni, Raoudha Ellouz-Ghorbel
Enzymatic hydrolysis of water-soluble polysaccharides from potato peel waste (PPPW) generates low molecular weight oligosaccharides with a yield of 63%. The oligosaccharides generated from potato peel polysaccharides (OPPP) were purified by Superdex-30 column. The results showed the presence of 8 peaks (OPPP1-OPPP8). The identification of all the fractions by chromatography analysis (GC-FID) illustrated that the most prominent residues were glucose with traces of galactose, arabinose and rhamnose. Finally, mass spectrometry (MALDI-ToF-ToF) analysis showed that the generated oligosaccharides were heterogeneous and contained different degree of polymerization (DP)...
February 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29407345/factors-related-to-intention-to-stay-in-the-current-workplace-among-long-term-care-nurses-a-nationwide-survey
#15
Sameh Eltaybani, Maiko Noguchi-Watanabe, Ayumi Igarashi, Yumiko Saito, Noriko Yamamoto-Mitani
BACKGROUND: Keeping long-term care nurses employed is necessary to sustain the current and future demand for high-quality long-term care services. Understanding the factors relating to intention to stay among long-term care nurses is limited by the scarcity of studies in long-term care settings, lack of investigation of multiple factors, and the weakness of existing explanatory models. OBJECTIVE: To identify the factors associated with long-term care nurses' intention to stay in their current workplace...
February 2, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29407236/drug-resistance-profile-and-molecular-characterization-of-extended-spectrum-beta-lactamase-es%C3%AE-l-producing-pseudomonas-aeruginosa-isolated-from-burn-wound-infections-essential-oils-and-their-potential-for-utilization
#16
Wagih A El-Shouny, Sameh S Ali, Jianzhong Sun, Sara M Samy, Asmaa Ali
OBJECTIVES: Pseudomonas aeruginosa producing extended spectrum β-lactamase (ESβL) enzyme had the ability for antimicrobial resistance mechanisms and its multidrug-resistant (MDR) phenotype, has been increasingly reported as a major clinical concern worldwide. The aim of this study was to (i) characterize ESβL-producing MDR P. aeruginosa isolated from burn wound infections phenotypically and molecularly, (ii) evaluate the antibacterial activity of some essential oils (EOs) against selected ESβL-producing drug resistant P...
February 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29404367/paradoxical-emboli-following-a-pulmonary-embolus-in-the-presence-of-a-patent-foramen-ovale
#17
Khalid Najib, Mark Heckle, Sameh Goubran, Rhadika Mehta, Rohan Goswami, Rami N Khouzam
A paradoxical embolism is defined as a systemic arterial embolus due to passage of a venous thrombus through a right to left shunt. We describe a case of acute cerebral vascular accident (CVA), right subclavian arterial embolus, and pulmonary emboli in the setting of a large patent foramen ovale (PFO). A 74-year-old woman with multiple comorbidities presented to the emergency department with acute onset of shortness of breath, weakness, and right arm pain. She was found to have bilateral pulmonary emboli, left CVA, and a right subclavian arterial embolus on computed tomography (CT)...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29392975/respiratory-digestive-tract-fistula-two-center-retrospective-observational-study
#18
Sameh I Sersar, Lamees A Maghrabi
Background Aerodigestive fistulae can be defined as abnormal communications between the gastrointestinal tract and the respiratory tract. Choking after meals, coughing, feeding difficulties, tachycardia, and persistent pneumonia are the main presentations. The aim of our study was to review our experience in the management of 27 cases of acquired aerodigestive fistulae of different types, levels, and management. Methods We conducted a retrospective observational study on 27 cases of fistulae between the respiratory and digestive tracts, which were managed in 2 hospitals in Saudi Arabia in the last 5 years...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29387956/predictive-factors-for-intestinal-transmural-necrosis-in-patients-with-acute-mesenteric-ischemia
#19
Sameh Hany Emile
BACKGROUND: Acute mesenteric ischemia (AMI) is a serious and potentially fatal condition. No definite parameter can predict transmural bowel necrosis in patients with AMI to justify early surgical intervention. The current study aimed to identify the clinical, laboratory, and radiologic parameters that can successfully predict the onset of intestinal transmural necrosis in patients with AMI. PATIENTS AND METHODS: Records of patients with AMI in the period of January 2013 to October 2017 were reviewed...
January 31, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29373009/genome-mining-and-assembly-line-biosynthesis-of-the-ucs1025a-pyrrolizidinone-family-of-fungal-alkaloids
#20
Li Li, Man-Cheng Tang, Shoubin Tang, Shu-Shan Gao, Sameh S M Soliman, Leibniz Hang, Wei Xu, Tao Ye, Kenji Watanabe, Yi Tang
UCS1025A is a fungal polyketide/alkaloid that displays strong inhibi-tion of telomerase. The structures of UCS1025A and related natural products are featured by a tricyclic furopyrrolizidine connected to a trans-decalin fragment. We mined the genome of a thermophilic fungus and activated the ucs gene cluster to produce UCS1025A at a high titer. Genetic and biochemical analysis revealed a PKS-NRPS assembly line that activates 2S,3S-methylproline derived from L-isoleucine, followed by Knoevenagel condensation to construct the pyrrolizidine moiety...
January 26, 2018: Journal of the American Chemical Society
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