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Contrast induced acute kidney injury

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https://www.readbyqxmd.com/read/28424213/magnesium-improves-cisplatin-mediated-tumor-killing-while-protecting-against-cisplatin-induced-nephrotoxicity
#1
Gopal Kumar, Malvika H Solanki, Xiangying Xue, Rachel Mintz, Swati Madankumar, Proydot K Chatterjee, Christine N Metz
Approximately 30% of all cancer patients treated with cisplatin, a widely used, broad-spectrum chemotherapeutic agent, experience acute kidney injury (AKI). Almost all patients receiving cisplatin have magnesium (Mg) losses, which are proposed to aggravate AKI. Currently, there are no methods to successfully treat or prevent cisplatin-AKI. While Mg supplementation has been shown to reduce AKI in experimental models and several small clinical trials, the effects of Mg status on tumor outcomes in immunocompetent tumor-bearing mice and humans have not been investigated...
April 19, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28423497/drp1-dependent-mitophagy-protects-against-cisplatin-induced-apoptosis-of-renal-tubular-epithelial-cells-by-improving-mitochondrial-function
#2
Chuanyan Zhao, Zhuyun Chen, Jia Qi, Suyan Duan, Zhimin Huang, Chengning Zhang, Lin Wu, Ming Zeng, Bo Zhang, Ningning Wang, Huijuan Mao, Aihua Zhang, Changying Xing, Yanggang Yuan
Cisplatin chemotherapy often causes acute kidney injury (AKI) in cancer patients. There is increasing evidence that mitochondrial dysfunction plays an important role in cisplatin-induced nephrotoxicity. Degradation of damaged mitochondria is carried out by mitophagy. Although mitophagy is considered of particular importance in protecting against AKI, little is known of the precise role of mitophagy and its molecular mechanisms during cisplatin-induced nephrotoxicity. Also, evidence that activation of mitophagy improved mitochondrial function is lacking...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412091/lansoprazole-halts-contrast-induced-nephropathy-through-activation-of-nrf2-pathway-in-rats
#3
Sahar A Khaleel, Amany A Alzokaky, Nahed A Raslan, Asmaa I Alwakeel, Heba G Abd El-Aziz, Adel R Abd-Allah
Contrast-induced nephropathy (CIN) is an important cause of acute kidney injury characterized by significant mortality and morbidity. To date, there is no successful protective regimen for CIN especially in poor kidney function patients. Lansoprazole has been shown to exert antioxidant action through induction of nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. The aim of the present study is to investigate the potential of lansoprazole to activate Nrf2 pathway in the kidney and consequently to protect against oxidative stress induced by iodinated contrast media...
April 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28400120/impact-of-point-of-care-pre-procedure-creatinine-and-egfr-testing-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-pci-the-pilot-statcreat-study
#4
Grigoris V Karamasis, James Hampton-Till, Firas Al-Janabi, Shah Mohdnazri, Michael Parker, Adam Ioannou, Rohan Jagathesan, Alagmir Kabir, Jeremy W Sayer, Nicholas M Robinson, Rajesh K Aggarwal, Gerald J Clesham, Reto A Gamma, Paul A Kelly, Kare H Tang, John R Davies, Thomas Keeble
BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) is a recognised complication during primary PCI that affects short and long term prognosis. The aim of this study was to assess the impact of point-of-care (POC) pre-PPCI creatinine and eGFR testing in STEMI patients. METHODS: 160 STEMI patients (STATCREAT group) with pre-procedure POC testing of Cr and eGFR were compared with 294 consecutive retrospective STEMI patients (control group). Patients were further divided into subjects with or without pre-existing CKD...
April 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28392272/a-new-preprocedure-risk-score-for-predicting-contrast-induced-acute-kidney-injury
#5
Chongyang Duan, Yingshu Cao, Yong Liu, Lizhi Zhou, Kaike Ping, Ming T Tan, Ning Tan, Jiyan Chen, Pingyan Chen
BACKGROUND: Most of the risk models for predicting contrast-induced acute kidney injury (CI-AKI) are available for only postcontrast exposure prediction; however, prediction before the procedure is more valuable in practice. This study aimed to develop a risk scoring system based on preprocedural characteristics for early prediction of CI-AKI in patients after coronary angiography or percutaneous coronary intervention (PCI). METHODS: We prospectively recruited 1777 consecutive patients who were randomized in an approximate 3:2 ratio to create a development data set (n = 1076) and a validation data set (n = 701)...
January 28, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28378840/alpha-lipoic-acid-ameliorates-the-epithelial-mesenchymal-transition-induced-by-unilateral-ureteral-obstruction-in-mice
#6
Hyun Seop Cho, Jin Hyun Kim, Ha Nee Jang, Tae Won Lee, Myeong Hee Jung, Tae Ho Kim, Se-Ho Chang, Dong Jun Park
The epithelial-to-mesenchymal transition (EMT) is one of mechanisms that induce renal interstitial fibrosis. Understanding EMT in renal fibrosis has important therapeutic implications for patients with kidney disease. Alpha-lipoic acid (ALA) is a natural compound with antioxidant properties. Studies for ALA are performed in acute kidney injury with renal tubular apoptosis, renal inflammation, and oxidative stress. We investigated the effects of ALA on EMT-mediated renal interstitial fibrosis in mice with unilateral ureteral obstruction (UUO)...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28378735/-value-of-n-terminal-pro-brain-natriuretic-peptide-in-predicting-acute-kidney-injury-in-patients-with-acute-decompensated-chronic-heart-failure
#7
M V Menzorov, A M Shutov, V I Midlenko, N V Larionova, I V Morozova, O V Akulova
AIM: To investigate the prognostic value of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) in the development of acute kidney injury (AKI) in patients with acute decompensated chronic heart failure (ADCHF). SUBJECTS AND METHODS: Eighty-three patients (55 (66%) men and 28 (34%) women; mean age, 65±11 years) with ADCHF were examined. AKI was diagnosed and classified according to the 2012 Kidney Disease Improving Global Outcomes Clinical Practice guidelines...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28371878/differences-in-acute-kidney-injury-ascertainment-for-clinical-and-preclinical-studies
#8
Marco Fiorentino, Giuseppe Castellano, John A Kellum
Background: . Acute kidney injury (AKI) is a common clinical condition directly associated with adverse outcomes. Several AKI biomarkers have been discovered, but their use in clinical and preclinical studies has not been well examined. This study aims to investigate the differences between clinical and preclinical studies on AKI biomarkers. Methods: . We performed a systematic review of clinical and preclinical interventional studies that considered AKI biomarkers in enrollment criteria and/or outcome assessment and described the main differences according to their setting, the inclusion of biomarkers in the definition of AKI and the use of biomarkers as primary or secondary end points...
March 23, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28356286/early-but-not-late-treatment-with-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-attenuates-cisplatin-nephrotoxicity-through-immunomodulation
#9
Ji Hyeon Park, Hye Ryoun Jang, Do Hee Kim, Ghee Young Kwon, Jung Eun Lee, Wooseong Huh, Soo Jin Choi, Wonil Oh, Ha Young Oh, Yoon-Goo Kim
Preemptive treatment with mesenchymal stem cells (MSCs) can attenuate cisplatin-induced acute kidney injury (AKI). However, it is uncertain whether MSC treatment after the development of renal dysfunction prevents AKI progression, or if their immunomodulatory properties contribute to MSC therapy. In this study, human umbilical cord blood (hUCB)-derived MSCs were used to compare the effects and mechanisms of early and late MSC therapy in a murine model. After cisplatin injection into C57BL/6 mice, hUCB-MSCs were administered on day 1 (early treatment) or day 3 (late treatment)...
March 29, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28331061/an-intracellular-matrix-metalloproteinase-2-isoform-induces-tubular-regulated-necrosis-implications-for-acute-kidney-injury
#10
Carla S Ceron, Celine Baligand, Sunil K Joshi, Shaynah Wanga, Patrick M Cowley, Joy P Walker, Sang Heon Song, Rajeev Mahimkar, Anthony J Baker, Robert L Raffai, Zhen J Wang, David H Lovett
Acute kidney injury (AKI) causes severe morbidity, mortality, and chronic kidney disease (CKD). Mortality is particularly marked in the elderly and with pre-existing CKD. Oxidative stress is a common theme in models of AKI induced by ischemia/reperfusion (I/R) injury. We recently characterized an intracellular isoform of matrix metalloproteinase-2 (MMP-2) induced by oxidative stress-mediated activation of an alternate promoter in the first intron of the MMP-2 gene. This generates an N-terminal truncated MMP-2 isoform (NTT-MMP-2) that is intracellular and associated with mitochondria...
March 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28320994/a-nomogram-to-predict-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#11
Xun Hu, Xiao-Dong Zhuang, Yi Li, Fei-Fei Li, Yue Guo, Zhi-Min Du, Xin-Xue Liao
Contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired acute kidney injury (AKI). Emerging evidence has revealed that soluble klotho (sklotho) could be a novel biomarker for early AKI diagnosis. The aims of this study were to assess the predictive role of sklotho for CIN and to develop a prediction nomogram in patients undergoing percutaneous coronary intervention (PCI). This study is registered on Clinicaltrials.gov (NCT 02650336).Patients aged 18 years or older undergoing planned PCI were prospectively recruited between May 2014 and July 2015...
March 21, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28320854/nonsteroidal-mineralocorticoid-receptor-antagonist-finerenone-protects-against-acute-kidney-injury-mediated-chronic-kidney-disease-role-of-oxidative-stress
#12
Lionel Lattenist, Sebastian M Lechner, Smail Messaoudi, Alan Le Mercier, Soumaya El Moghrabi, Sonia Prince, Norma A Bobadilla, Peter Kolkhof, Frédéric Jaisser, Jonatan Barrera-Chimal
Acute kidney injury induced by ischemia/reperfusion (IR) is a frequent complication in hospitalized patients. Mineralocorticoid receptor antagonism has shown to be helpful against renal IR consequences; however, the potential benefit of novel nonsteroidal mineralocorticoid receptor antagonists such as finerenone has to be further explored. In this study, we evaluated the efficacy of finerenone to prevent the acute and chronic consequences of ischemic acute kidney injury. For the acute study (24 hours), 18 rats were divided into sham, bilateral renal ischemia of 25 minutes, and rats that received 3 doses of finerenone at 48, 24, and 1 hour before the ischemia...
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28281738/efficacy-of-nicorandil-treatment-for-prevention-of-contrast-induced-nephropathy-in-high-risk-patients-undergoing-cardiac-catheterization-a-prospective-randomized-controlled-trial
#13
Leili Iranirad, Seyed Fakhreddin Hejazi, Mohammad Saleh Sadeghi, Shahram Arsang Jang
BACKGROUND: Contrast-induced nephropathy (CIN) remains to be a potentially serious complication of radiographic procedures and is the third leading cause of the acute kidney injury (AKI) among hospitalized patients. This clinical trial was performed to assess the preventive effect of oral nicorandil on CIN in high-risk patients undergoing cardiac catheterization. METHODS: In this prospective, randomized, controlled trial, 128 patients with at least two risk factors for CIN undergoing elective percutaneous coronary intervention (PCI) were randomly assigned to either the nicorandil group or the control group...
March 10, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28280699/contrast-induced-acute-kidney-injury-in-kidney-transplant-recipients-a-systematic-review-and-meta-analysis
#14
Wisit Cheungpasitporn, Charat Thongprayoon, Michael A Mao, Shennen A Mao, Matthew R D'Costa, Wonngarm Kittanamongkolchai, Kianoush B Kashani
AIM: To evaluate the incidence of contrast-induced acute kidney injury (CIAKI) in kidney transplant recipients. METHODS: A literature search was performed using MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews from the inception of the databases through July 2016. Studies assessing the incidence of CIAKI in kidney transplant recipients were included. We applied a random-effects model to estimate the incidence of CIAKI. RESULTS: Six studies of 431 kidney transplant recipients were included in the analyses to assess the incidence of CIAKI in kidney transplant recipients...
February 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28272231/association-of-n-terminal-pro-brain-natriuretic-peptide-with-contrast-induced-acute-kidney-injury-and-long-term-mortality-in-patients-with-heart-failure-and-mid-range-ejection-fraction-an-observation-study
#15
Kun Wang, Hua-Long Li, Li-Ling Chen, Wei-Jie Bei, Kai-Yang Lin, Brendan Smyth, Shi-Qun Chen, Xiao-Sheng Guo, Wei Guo, Yuan-Hui Liu, Peng-Yuan Chen, Ji-Yan Chen, Kai-Hong Chen, Yong Liu, Ning Tan
The potential value of N-terminal pro-brain natriuretic peptide (NT-proBNP) for contrast-induced acute kidney injury (CI-AKI) in patients with heart failure and mid-range ejection fraction (HFmrEF) is unclear. We investigated whether NT-proBNP is associated with CI-AKI and long-term mortality following elective cardiac catheterization in patients with HFmrEF.A total of 174 consecutive patients with HFmrEF undergoing elective coronary angiography or intervention were enrolled. The primary endpoint was the development of CI-AKI, defined as an absolute increase of ≥0...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28243357/comparison-of-effects-of-different-statins-on-contrast-induced-acute-kidney-injury-in-rats-histopathological-and-biochemical-findings
#16
COMPARATIVE STUDY
Xiao-Lei Wang, Tuo Zhang, Liu-Hua Hu, Shi-Qun Sun, Wei-Feng Zhang, Zhe Sun, Ling-Hong Shen, Ben He
Statins are a promising new strategy to prevent contrast-induced acute kidney injury (CI-AKI). In this study we compared the ameliorative effect of different statins in a rat model of CI-AKI. Sprague-Dawley rats were divided into five groups: control group; CI-AKI group; CI-AKI + rosuvastatin group (10 mg/kg/day); CI-AKI + simvastatin group (80 mg/kg/day); and CI-AKI + atorvastatin group (20 mg/kg/day). CI-AKI was induced by dehydration for 72 hours, followed by furosemide intramuscular injection 20 minutes before low-osmolar contrast media (CM) intravenous injection...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28236468/volume-expansion-and-contrast-induced-acute-kidney-injury
#17
Peter A McCullough, Jun Zhang, Claudio Ronco
No abstract text is available yet for this article.
April 1, 2017: Lancet
https://www.readbyqxmd.com/read/28219627/antithrombin-iii-protects-against-contrast-induced-nephropathy
#18
Zeyuan Lu, Dongsheng Cheng, Jianyong Yin, Rui Wu, Guangyuan Zhang, Qing Zhao, Niansong Wang, Feng Wang, Mingyu Liang
We previously reported that insufficiency of antithrombin III (ATIII), the major anti-coagulation molecule in vivo, exacerbated renal ischemia-reperfusion injury in animal models and possibly humans. In the present study, we investigated the relationship between ATIII level and contrast induced nephropathy (CIN) in patients and examined therapeutic effect of ATIII on CIN in Sprague-Dawley rats. Patients with low ATIII activity presented a higher incidence of acute kidney injury (AKI) following coronary angiography...
March 2017: EBioMedicine
https://www.readbyqxmd.com/read/28218266/crystal-nephropathies-mechanisms-of-crystal-induced-kidney-injury
#19
REVIEW
Shrikant R Mulay, Hans-Joachim Anders
Crystals can trigger a wide range of kidney injuries that can lead to acute kidney injury, chronic kidney disease, renal colic or nephrocalcinosis, depending on the localization and dynamics of crystal deposition. Studies of the biology of crystal handling by the kidney have shown that the formation of different crystals and other microparticles and the associated mechanisms of renal damage share molecular mechanisms, such as stimulation of the NLRP3 inflammasome or direct cytotoxicity through activation of the necroptosis signalling pathway...
April 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28205100/efficacy-of-oral-supplemental-hydration-for-the-prevention-of-contrast-induced-nephropathy-in-rats
#20
Tamaki Matsunami, Kazuo Hino, Rie Dosho, Sho Miyatake, Goro Ebisu, Ryohei Kuwatsuru
PURPOSE: To compare oral rehydration solution (ORS) with saline infusion for preventing contrast-induced nephropathy (CIN) in a rat model. MATERIALS AND METHODS: Adult male Sprague-Dawley rats (310-360 g) received intravenous indomethacin (10 mg/kg), N (G)-nitro-L-arginine methyl ester (10 mg/kg), and iohexol (10 mL/kg) to induce acute contrast-induced renal injury (CIN group); control rats received saline only. For hydration, rats received either continuous infusion (20 mL/kg/h) of saline or three oral doses (20 mL/kg each) of ORS...
February 15, 2017: Japanese Journal of Radiology
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