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Contrast induced acute kidney injury

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https://www.readbyqxmd.com/read/29445145/canagliflozin-mediated-dual-inhibition-of-mitochondrial-glutamate-dehydrogenase-and-complex-i-an-off-target-adverse-effect
#1
Philipp F Secker, Sascha Beneke, Nadja Schlichenmaier, Johannes Delp, Simon Gutbier, Marcel Leist, Daniel R Dietrich
Recent FDA Drug Safety Communications report an increased risk for acute kidney injury in patients treated with the gliflozin class of sodium/glucose co-transport inhibitors indicated for treatment of type 2 diabetes mellitus. To identify a potential rationale for the latter, we used an in vitro human renal proximal tubule epithelial cell model system (RPTEC/TERT1), physiologically representing human renal proximal tubule function. A targeted metabolomics approach, contrasting gliflozins to inhibitors of central carbon metabolism and mitochondrial function, revealed a double mode of action for canagliflozin, but not for its analogs dapagliflozin and empagliflozin...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29422997/hucmsc-exosomes-delivered-14-3-3%C3%AE-enhanced-autophagy-via-modulation-of-atg16l-in-preventing-cisplatin-induced-acute-kidney-injury
#2
Haoyuan Jia, Wanzhu Liu, Bin Zhang, Juanjuan Wang, Peipei Wu, Nitin Tandra, Zhaofeng Liang, Cheng Ji, Lei Yin, Xinyuan Hu, Yongmin Yan, Fei Mao, Xu Zhang, Jing Yu, Wenrong Xu, Hui Qian
The clinical application of cisplatin is restricted by its side effects of nephrotoxicity. Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-ex) have an important effect in tissue injury repair. Our previous work discovered that pretreatment with human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-ex) alleviated cisplatin-induced acute kidney injury (AKI) by activating autophagy both in vitro and in vivo. In this study, we further explored the mechanisms of hucMSC-ex in autophagy for preventing cisplatin-induced nephrotoxicity...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29420536/randomized-trial-of-one-hour-sodium-bicarbonate-vs-standard-periprocedural-saline-hydration-in-chronic-kidney-disease-patients-undergoing-cardiovascular-contrast-procedures
#3
Judith Kooiman, Jean-Paul P M de Vries, Jan Van der Heyden, Yvo W J Sijpkens, Paul R M van Dijkman, Jan J Wever, Hans van Overhagen, Antonie C Vahl, Nico Aarts, Iris J A M Verberk-Jonkers, Harald F H Brulez, Jaap F Hamming, Aart J van der Molen, Suzanne C Cannegieter, Hein Putter, Wilbert B van den Hout, Inci Kilicsoy, Ton J Rabelink, Menno V Huisman
BACKGROUND: Guidelines advise periprocedural saline hydration for prevention of contrast induced-acute kidney injury (CI-AKI). We analysed whether 1-hour sodium bicarbonate hydration administered solely prior to intra-arterial contrast exposure is non-inferior to standard periprocedural saline hydration in chronic kidney disease (CKD) patients undergoing elective cardiovascular diagnostic or interventional contrast procedures. METHODS: We performed an open-label multicentre non-inferiority trial between 2011-2014...
2018: PloS One
https://www.readbyqxmd.com/read/29402790/unravelling-pathophysiology-of-crystalline-nephropathy-in-ceftriaxone-associated-acute-kidney-injury-a-cellular-proteomic-approach
#4
Supawat Chatchen, Nutkridta Pongsakul, Chantragan Srisomsap, Wararat Chiangjong, Suradej Hongeng, Jisnuson Svasti, Somchai Chutipongtanate
BACKGROUND: Previous studies showed that ceftriaxone can cause acute kidney injury (AKI) in the pediatric population. This study proposed a cellular model of crystalline nephropathy in ceftriaxone-associated AKI and explored the related pathophysiology by using a proteomic approach. METHODS: Ceftriaxone was crystallized with calcium in artificial urine. Madin-Darby Canine Kidney (MDCK) cells, a model of distal renal tubular cell, were cultured in the absence (untreated control) or presence of ceftriaxone crystals for 48-h (n = 5 each)...
January 16, 2018: Nephron
https://www.readbyqxmd.com/read/29402367/-continuous-contrast-enhanced-ultrasound-applied-to-acute-kidney-injury-caused-by-sepsis-a-diagnostic-clinical-study
#5
Junyi Wang, Xinjing Gao, Dong Wang, Zhiyong Wang, Zhibo Li, Dong Liu, Lei Xu
OBJECTIVE: To evaluate the diagnostic value of contrast-enhanced ultrasound in acute kidney injury (AKI) caused by sepsis. METHODS: The sepsis patients admitted to intensive care unit of Tianjin Third Central Hospital from January 2015 to June 2017 were enrolled. All of the patients were completed the 6-hour Bundle treatment and the bilateral renal contrast-enhanced ultrasound within 24 hours, and the peak signal intensity (PSI), peak intensity time (PIT), wash internal rate (WIR) and renal function parameters were measured at the same time...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29402223/morg1-mice-are-protected-from-histological-renal-damage-and-inflammation-in-a-murine-model-of-endotoxemia
#6
Tzvetanka Bondeva, Claudia Schindler, Katrin Schindler, Gunter Wolf
BACKGROUND: The MAPK-organizer 1 (MORG1) play a scaffold function in the MAPK and/or the PHD3 signalling paths. Recently, we reported that MORG1+/- mice are protected from renal injury induced by systemic hypoxia and acute renal ischemia-reperfusion injury via increased hypoxia-inducible factors (HIFs). Here, we explore whether MORG1 heterozygosity could attenuate renal injury in a murine model of lipopolysaccharide (LPS) induced endotoxemia. METHODS: Endotoxemia was induced in mice by an intraperitoneal (i...
February 5, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29397881/incidence-predictors-and-impact-on-six-month-mortality-of-three-different-definitions-of-contrast-induced-acute-kidney-injury-after-coronary-angiography
#7
Benoit Guillon, Fiona Ecarnot, Charles Marcucci, Didier Ducloux, Marion Chatot, Marc Badoz, Benjamin Bonnet, Romain Chopard, Pierre Frey, Nicolas Meneveau, François Schiele
We assessed incidence, predictors, and impact on 6-month mortality of contrast-induced acute kidney injury (CI-AKI) after coronary angiography with or without percutaneous coronary intervention in patients with acute coronary syndrome (ACS), according to 3 different CI-AKI definitions. Serum creatinine (sCr) was assessed at baseline and 48 to 72 hours after procedure to classify patients into 3 CI-AKI groups: Group 1: increase in sCR ≥25% over baseline but absolute increase <0.5 mg/dl; Group 2: absolute increase ≥0...
January 9, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29390255/could-late-measurement-of-serum-creatinine-be-missed-for-patients-without-early-increase-in-serum-creatinine-following-coronary-angiography
#8
Yong Liu, Chong-Yang Duan, Kun Wang, Wei-Jie Bei, Xiao-Sheng Guo, Hua-Long Li, Ying Wang, Shi-Qun Chen, Ying Xian, Ping-Yan Chen, Qing-Shan Geng, Ning Tan, Ji-Yan Chen
Most patients are discharged early (within 24 hours) after coronary angiography (CAG) and may miss identification the late (24-48 hours) increase in serum creatinine (SCr), whose characteristics and prognosis have been less intensively investigated.We prospectively recruited 3065 consecutive patients with SCr measurement, including only1344 patients with twice SCr measurement (both early and late). The late contrast-induced acute kidney injury (CI-AKI) was defined as significantly increase in SCr (≥0...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381498/effectiveness-of-oral-hydration-in-preventing-contrast-induced-acute-kidney-injury-in-patients-undergoing-coronary-angiography-or-intervention-a-pairwise-and-network-meta-analysis
#9
Weidai Zhang, Jiawei Zhang, Baojun Yang, Kefei Wu, Hanfei Lin, Yanping Wang, Lihong Zhou, Huatao Wang, Chujuan Zeng, Xiao Chen, Zhixing Wang, Junxing Zhu, Chen Songming
BACKGROUND: The effectiveness of oral hydration in preventing contrast-induced acute kidney injury (CI-AKI) in patients undergoing coronary angiography or intervention has not been well established. This study aims to evaluate the efficacy of oral hydration compared with intravenous hydration and other frequently used hydration strategies. METHODS: PubMed, Embase, Web of Science, and the Cochrane central register of controlled trials were searched from inception to 8 October 2017...
January 29, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29373136/impact-of-a-novel-contrast-reduction-system-on-contrast-savings-in-coronary-angiography-the-dyevert-randomised-controlled-trial
#10
Steffen Desch, Georg Fuernau, Janine Pöss, Roza Meyer-Saraei, Mohammed Saad, Ingo Eitel, Holger Thiele, Suzanne de Waha
AIMS: The most prominent procedure-related and thus modifiable risk factor for contrast-induced acute kidney injury is contrast media (CM) volume. The DyeVert™ system has been designed to reduce the amount of CM. The primary objective of this randomised controlled trial was thus to examine whether the novel DyeVert™ contrast reduction system (Osprey Medical Inc., Minnetonka, MN, USA) leads to a reduction in CM volume in patients undergoing diagnostic coronary angiography. METHODS: Patients scheduled for a diagnostic coronary angiogram were randomised to angiography with or without the DyeVert™ system...
January 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29371869/allopurinol-prophylactic-therapy-and-the-prevention-of-contrast-induced-nephropathy-in-high-risk-patients-undergoing-coronary-angiography-a-prospective-randomized-controlled-trial
#11
Leili Iranirad, Mohammad Saleh Sadeghi, Ahmadreza Bagheri, Kobra Doostali, Samieh Norouzi, Seyed Fakhreddin Hejazi, Hossein Saghafi, Sakineh Roshani-Mobaraki
BACKGROUND: Contrast-induced nephropathy (CIN) is considered to be a possibly severe complication of radiography and thus, remains to be the main cause of acute kidney injury (AKI) for inpatients. A clinical trial was executed to measure the preventive effect of allopurinol against CIN in high-risk patients undertaking coronary angiography. METHODS: Through randomized controlled trial, 140 patients with at minimum two risk factors of CIN, undertaking coronary angiography, were randomly allocated to the allopurinol (n = 70) or control group (n = 70)...
September 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29368247/astaxanthin-attenuates-contrast-agent-induced-acute-kidney-injury-in-vitro-and-in-vivo-via-the-regulation-of-sirt1-foxo3a-expression
#12
Nana Liu, Jing Chen, Dongmei Gao, Wenhua Li, Di Zheng
PURPOSE: The study was processed to investigate the effect of astaxanthin (AST; 3,3-dihydroxybeta, beta-carotene-4,4-dione) on the acute kidney injury induced by iohexol and the relationship with SIRT1/FOXO3a signal pathway. METHODS: Thirty male Sprague Dawley rats were randomly divided into five groups as follows: control group (CON; olive oil only), contrast media group, astaxanthin control group (100 mg/kg), low astaxanthin dose group (LAG, 50 mg/kg) and high astaxanthin dose group (HAG, 100 mg/kg)...
January 24, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29351418/red-blood-cell-antibody-induced-anemia-causes-differential-degrees-of-tissue-hypoxia-in-kidney-and-brain
#13
Nikhil Mistry, C David Mazer, John G Sled, Alan H Lazarus, Lindsay S Cahill, Max Solish, Yu-Qing Zhou, Nadya Romanova, Alexander Gm Hare, Allan Doctor, Joseph A Fisher, Keith R Brunt, Jeremy A Simpson, Gregory M T Hare
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. A red blood cell (RBC)-specific antibody model was utilized to determine if moderate subacute anemia could result in tissue hypoxia as a potential mechanism of injury. Cardiovascular and hypoxic cellular responses were measured in transgenic mice capable of expressing hypoxia-inducible factor-1α (HIF-1α)-luciferase activity in vivo. Antibody-mediated anemia was associated with mild intravascular hemolysis (6 hours) and splenic RBC sequestration (day 4), resulting in a nadir hemoglobin concentration of 89{plus minus}13 g/L at day 4...
January 10, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29329731/multimodality-imaging-evaluation-before-transcatheter-aortic-valve-implantation-incidence-of-contrast-medium-induced-acute-kidney-injury-risk-factors-and-prognosis
#14
C Schneider, A Brumberg, F C Roller, J Rixe, P Roth, G A Krombach
AIM: To evaluate the incidence, risk factors, and prognostic implications of contrast medium-induced acute kidney injury (CI-AKI) in patients undergoing transcatheter aortic valve implantation (TAVI) evaluation. MATERIALS AND METHODS: Datasets from 98 out of 207 consecutive patients referred for multidetector computed tomography (MDCT) for TAVI evaluation were eligible for evaluation and were analysed retrospectively. The incidence of CI-AKI was correlated to outcome and to potential risk factors: kidney function (estimated glomerular filtration rate [eGFR]), heart failure, diabetes, amount of contrast medium, and duration of examination period...
January 10, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29329317/oxidative-stress-caused-by-activation-of-nadph-oxidase-4-promotes-contrast-induced-acute-kidney-injury
#15
Bo Young Jeong, Hoi Young Lee, Chang Gyo Park, Jaeku Kang, Seong-Lan Yu, Du-Ri Choi, Seung-Yun Han, Moon Hyang Park, Sungkwon Cho, Soo Young Lee, Won-Min Hwang, Sung-Ro Yun, Hye-Myung Ryu, Eun-Joo Oh, Sun-Hee Park, Yong-Lim Kim, Se-Hee Yoon
Contrast-induced acute kidney injury (CIAKI) is a leading cause of acute kidney injury following radiographic procedures. Intrarenal oxidative stress plays a critical role in CIAKI. Nicotinamide adenine dinucleotide 3-phosphate (NADPH) oxidases (Noxs) are important sources of reactive oxygen species (ROS). Among the various types of Noxs, Nox4 is expressed predominantly in the kidney in rodents. Here, we evaluated the role of Nox4 and benefit of Nox4 inhibition on CIAKI using in vivo and in vitro models. HK-2 cells were treated with iohexol, with or without Nox4 knockdown, or the most specific Nox1/4 inhibitor (GKT137831)...
2018: PloS One
https://www.readbyqxmd.com/read/29322699/contrast-induced-acute-kidney-injury-and-inflammation
#16
EDITORIAL
Kyeong Ho Yun
No abstract text is available yet for this article.
January 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29312646/predictive-value-of-post-procedural-early-within-24-h-increase-in-cystatin-c-for-contrast-induced-acute-kidney-injury-and-mortality-following-coronary-angiography-or-intervention
#17
Yong Liu, Kai-Hong Chen, Shi-Qun Chen, Li-Ling Chen, Chong-Yang Duan, Kun Wang, Xiao-Sheng Guo, Hua-Long Li, Wei-Jie Bei, Kai-Yan Lin, Ping-Yan Chen, Ying Xian, Ning Tan, Ying-Ling Zhou, Qing-Shan Geng, Ji-Yan Chen
Objective: To investigate the predictive value of post-procedural early (within 24 h) increase in cystatin C for contrast-induced acute kidney injury (CI-AKI) and all-cause mortality following coronary angiography or intervention. Methods: We prospectively investigated 1042 consecutive patients with both baseline and early post-procedural cystatin C measurement undergoing coronary angiography or intervention. CI-AKI was defined as an increase ≥0.3 mg/dL or >50% in serum creatinine from baseline within 48 h post-procedure...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29281937/contrast-induced-acute-kidney-injury-beware-of-the-risk-after-coronary-angiography
#18
Niki Katsiki, Costas Tsioufis, George Hahalis, Vasilios G Athyros
No abstract text is available yet for this article.
December 27, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29261551/maximum-allowable-contrast-dose-and-prevention-of-acute-kidney-injury-following-cardiovascular-procedures
#19
Joe Aoun, Diala Nicolas, Jeremiah R Brown, Bertrand L Jaber
PURPOSE OF REVIEW: Contrast-induced acute kidney injury (CI-AKI) is a serious complication. Although nonmodifiable and modifiable risk factors have been thoroughly characterized, the utility of the maximal allowable contrast dose (MACD) has not received adequate attention. The focus of this review is to provide a critical appraisal of this modifiable risk factor. RECENT FINDINGS: Several retrospective and prospective cohort studies have demonstrated that the incidence of CI-AKI among patients receiving contrast media in volumes exceeding the MACD is consistently higher compared with those who do not exceed the MACD (an average of 24 vs...
March 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29237046/exposure-to-contrast-media-in-the-perioperative-period-confers-no-additional-risk-of-acute-kidney-injury-in-surgical-patients
#20
Ian Zealley, Huan Wang, Peter T Donnan, Samira Bell
Background: Iodinated contrast media (CM) used in angiography and computed tomography (CT) scans is an important cause of acute kidney injury (AKI) in hospitalized patients undergoing surgery. Contrast-induced nephropathy leads to AKI soon after CM administration. The aim of the study was to determine whether the timing of contrast media exposure related to diagnostic imaging during the immediate perioperative period influences the risk of post-operative AKI. Methods: All patients aged 18 years or above who underwent diagnostic imaging within 7 days of non-cardiac surgery between 1 January 2003 and 31 December 2013 in the Tayside region of Scotland, UK were included in the analysis...
December 9, 2017: Nephrology, Dialysis, Transplantation
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