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https://www.readbyqxmd.com/read/28915972/suprachoroidal-injection-of-biological-agents-may-have-a-potential-role-in-the-prevention-of-progression-and-complications-in-high-myopia
#1
Pradeep Venkatesh, Brijesh Takkar
The prevalence of myopia and its severe/progressive visually impairing forms is increasing all over the globe. Most of the preliminary clinical research has focused on rehabilitation and treatment of its complications. Pharmacological prevention of myopic progression has shown encouraging results recently and currently the scleral structure is believed to be responsible for disease progression. In this article, we have hypothesized injecting a biological cement in the potential space between the choroid and the sclera to halt the progressive elongation of the eye ball while preventing complications related to myopia...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28912514/retinal-changes-following-rapid-ascent-to-a-high-altitude-environment
#2
X Tian, B Zhang, Y Jia, C Wang, Q Li
PurposeTo determine what impact rapid ascension to a high-altitude environment has on the retina with the aim of preventing and treating high-altitude oculopathy.Patients and methodsParticipants in the study were members of the Chinese military assigned to the high-altitude environment of the Tibetan plateau. Ninety-one participants were enrolled in the study. Optical coherence tomography was used to measure the thickness of retina-related indicators. Measurements were taken before and after exposure to the high-altitude environment and upon return to the baseline altitude...
September 15, 2017: Eye
https://www.readbyqxmd.com/read/28910179/phenotypic-differences-between-familial-versus-non-familial-juvenile-onset-open-angle-glaucoma-patients
#3
Viney Gupta, Ashish Markan, Bindu I Somarajan, Ramanjit Sihota, Amisha Gupta, Shikha Gupta, Arundhati Sharma
AIM: To evaluate phenotypic differences among familial and non-familial JOAG patients. METHODS: First degree relatives of unrelated JOAG patients were screened for glaucoma and ocular hypertension. JOAG probands were grouped as familial or non-familial and phenotypic differences in terms of age of onset, gender, baseline untreated IOP, presence angle dysgenesis, and refractive error was compared between the two groups. RESULTS: Out of 368 unrelated JOAG patients, 134 in whom all first degree relatives had been examined were included in the study...
September 14, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28905827/refractive-and-ocular-biometric-profile-of-children-with-a-history-of-laser-treatment-for-retinopathy-of-prematurity
#4
Savleen Kaur, Jaspreet Sukhija, Deeksha Katoch, Mansi Sharma, Ramanuj Samanta, Mangat R Dogra
PURPOSE: Indian children belong to a diverse socioeconomic strata with retinopathy of prematurity (ROP) developing in mature, higher birth weight babies as well. The purpose of our study is to analyze the long-term status of refractive errors and its relationship with ocular biometry in children with ROP who were laser treated at a tertiary center in North India. METHODS: Cross sectional study. Children (<16 years) enrolled from January 2014 to December 2014 with a history of laser treatment for ROP and examined for refractive and biometric status...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28900109/region-specific-differential-corneal-and-scleral-mrna-expressions-of-mmp2-timp2-and-tgfb2-in-highly-myopic-astigmatic-chicks
#5
Lisa Yan-Yan Xi, Shea Ping Yip, Sze Wan Shan, Jody Summers-Rada, Chea-Su Kee
Myopia and astigmatism, two common refractive errors frequently co-exist, are affecting vision at all working distances in the affected populations worldwide. Eyeballs having these refractive errors are known to exhibit abnormal eye shape at the anterior and posterior eye segments, but whether the outer coats of these abnormal eyeballs, cornea anteriorly and sclera posteriorly, are regulated by region-specific molecular mechanism remains unclear. Here we presented the changes in mRNA expression levels of three genes (MMP2, TIMP2, and TGFB2), all known to participate in extracellular matrix organization, at five regions of the cornea and sclera in chickens developing high myopia and astigmatism induced by form deprivation...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28898521/design-and-methodology-of-the-shanghai-child-and-adolescent-large-scale-eye-study-scale
#6
Xiangui He, Rong Zhao, Padmaja Sankaridurg, Jianfeng Zhu, Thomas John, Yingyan Ma, Lina Lu, Minzhi Lv, Earl L Smith, Serge Resnikoff, Kovin Naidoo, Haidong Zou, Xun Xu
IMPORTANCE: Nearly half of children suffering vision impairment reside in China with myopia accounting for the vast majority. BACKGROUND: To describe the design and methodology of the Shanghai Child and Adolescent Large-scale Eye Study (SCALE). DESIGN: The SCALE was a city wide, school-based, prospective survey. PARTICIPANTS: Children and adolescents aged 4 to 14 years from kindergarten (middle and senior), primary schools and junior high schools of all 17 districts and counties of the city of Shanghai, China were examined in 2012-2013...
September 12, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28893307/interventions-to-control-myopia-progression-in-children-protocol-for-an-overview-of-systematic-reviews-and-meta-analyses
#7
Efthymia Prousali, Asimina Mataftsi, Nikolaos Ziakas, Andreas Fontalis, Periklis Brazitikos, Anna-Bettina Haidich
BACKGROUND: Myopia is a common visual disorder with increasing prevalence among developed countries of the world. Myopia constitutes a substantial risk factor for several ocular conditions that can lead to blindness. The purpose of this study is to conduct an overview of systematic reviews and meta-analyses in order to identify and appraise robust research evidence regarding the management of myopia progression in children and adolescents. METHODS: A literature search will be conducted in MEDLINE, EMBASE, The Cochrane Database of Systematic Reviews (CDSR), Database of Abstracts of Reviews of Effects (DARE), and Health Technology Assessment (HTA) Database via Centre for Reviews and Dissemination (CRD)...
September 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28891727/methodology-of-the-zoc-bhvi-high-myopia-cohort-study-the-onset-and-progression-of-myopic-pathologies-and-associated-risk-factors-in-highly-myopic-chinese
#8
Yanxian Chen, Ou Xiao, Xinxing Guo, Decai Wang, Padmaja Sankaridurg, Ian Morgan, Mingguang He
PURPOSE: The increasing prevalence of high myopia and its associated pathologies has raised challenges to ophthalmic services. This project aims to explore the onset and progression of myopic pathologies in highly myopic eyes through a prospective research cohort established in South China. METHODS: Patients with high myopia (sphere ≤ -6.00 D) visiting the optometric clinic of Zhongshan Ophthalmic Center (ZOC) were invited to participate in the baseline examinations and follow-up visit over a 10-year period...
September 11, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28887137/effects-of-a-high-level-of-illumination-before-sleep-at-night-on-chorioretinal-thickness-and-ocular-biometry
#9
Jaemoon Ahn, Soh-Eun Ahn, Kyung-Sook Yang, Seong-Woo Kim, Jaeryung Oh
The choroid is affected by many factors. One of the factors, change in illumination has been suggested to influence choroidal thickness. However, the effects of bright light before sleep at night on the human eye are not well established. The purpose of this study was to investigate the effects of a high level of illumination in the evening on ocular measurements. Twenty-seven men with myopia spent seven consecutive nights in the sleep laboratory. During the first two nights, subjects were exposed to light at 150 lux between 20:00 and midnight...
September 5, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28886700/internal-limiting-membrane-peeling-and-gas-tamponade-for-myopic-foveoschisis-a-systematic-review-and-meta-analysis
#10
Bo Meng, Lu Zhao, Yi Yin, Hongyang Li, Xiaolei Wang, Xiufen Yang, Ran You, Jialin Wang, Youjing Zhang, Hui Wang, Ran Du, Ningli Wang, Siyan Zhan, Yanling Wang
BACKGROUND: Myopic foveoschisis (MF) is among the leading causes of visual loss in high myopia. However, it remains controversial whether internal limiting membrane (ILM) peeling or gas tamponade is necessary treatment option for MF. METHODS: PubMed, EMBASE, CBM, CNKI, WANFANG DATA and VIP databases were systematically reviewed. Outcome indicators were myopic foveoschisis resolution rate, visual acuity improvement and postoperative complications. RESULTS: Nine studies that included 239 eyes were selected...
September 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28884119/genetic-association-study-of-kcnq5-polymorphisms-with-high-myopia
#11
Xuan Liao, Maurice K H Yap, Kim Hung Leung, Patrick Y P Kao, Long Qian Liu, Shea Ping Yip
Identification of genetic variations related to high myopia may advance our knowledge of the etiopathogenesis of refractive error. This study investigated the role of potassium channel gene (KCNQ5) polymorphisms in high myopia. We performed a case-control study of 1563 unrelated Han Chinese subjects (809 cases of high myopia and 754 emmetropic controls). Five tag single-nucleotide polymorphisms (SNPs) of KCNQ5 were genotyped, and association testing with high myopia was conducted using logistic regression analysis adjusted for sex and age to give Pasym values, and multiple comparisons were corrected by permutation test to give Pemp values...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28882754/mini-review-far-peripheral-vision
#12
Michael J Simpson
The region of far peripheral vision, beyond 60 degrees of visual angle, is important to the evaluation of peripheral dark shadows (negative dysphotopsia) seen by some intraocular lens (IOL) patients. Theoretical calculations show that the limited diameter of an IOL affects ray paths at large angles, leading to a dimming of the main image for small pupils, and to peripheral illumination by light bypassing the IOL for larger pupils. These effects are rarely bothersome, and cataract surgery is highly successful, but there is a need to improve the characterization of far peripheral vision, for both pseudophakic and phakic eyes...
September 9, 2017: Vision Research
https://www.readbyqxmd.com/read/28858414/association-of-intraocular-pressure-related-factors-and-retinal-vessel-diameter-with-optic-disc-rim-area-in-subjects-with-and-without-primary-open-angle-glaucoma
#13
Qing Zhang, Catherine Jan, Chun Yu Guo, Feng Hua Wang, Yuan Bo Liang, Kai Cao, Zheng Zhang, Di Ya Yang, Ravi Thomas, Ning Li Wang
IMPORTANCE: The data may supports the notion that the mechanical and vascular mechanisms of glaucomatous injury are intertwined BACKGROUND: To study the association of intraocular pressure (IOP) related factors, IOP, trans-lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro-retinal rim area (RA). DESIGN: A population-based, cross-sectional study PARTICIPANTS: 6830 people aged 30 years and over...
August 31, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28852194/the-relationship-between-scleral-staphyloma-and-choroidal-thinning-in-highly-myopic-eyes-the-beijing-eye-study
#14
Ling Xiao Zhou, Lei Shao, Liang Xu, Wen Bin Wei, Ya Xing Wang, Qi Sheng You
Based on the Beijing Eye Study 2011, a detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging for measurement of subfoveal choroidal thickness (SFCT) and relative height of posterior scleral staphyloma. OCT images were obtained in 103 highly myopic eyes (≤-6.00 diopters) and 227 normal eyes. The mean SFCT in highly myopic eyes was 110.6 ± 85.2 μm (range, 3 to 395 μm). The SFCT of high myopia without posterior scleral staphyloma(55 eyes) was 157...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28852117/novel-evidence-for-complement-system-activation-in-chick-myopia-and-hyperopia-models-a-meta-analysis-of-transcriptome-datasets
#15
Nina Riddell, Sheila G Crewther
Myopia (short-sightedness) and hyperopia (long-sightedness) occur when the eye grows too long or short, respectively, for its refractive power. There are currently approximately 1.45 billion myopes worldwide and prevalence is rising dramatically. Although high myopia significantly increases the risk of developing a range of sight-threatening disorders, the molecular mechanisms underlying ocular growth regulation and its relationship to these secondary complications remain poorly understood. Thus, this study meta-analyzed transcriptome datasets collected in the commonly used chick model of optically-induced refractive error...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844325/-visual-outcomes-four-years-after-small-incision-lenticule-extraction-smile-surgery-on-highly-myopic-eyes-french-version
#16
J Burazovitch, D Naguzeswski, T Beuste, M Guillard
OBJECTIVE: To determine whether the visual outcomes of the refractive surgery technique, small incision lenticule extraction (SMILE), are stable, effective, and predictable for high myopia over a four-year period. RESEARCH DESIGN: This is a retrospective study. The data were collected between March 2012 and July 2016. PARTICIPANTS: Two hundred and forty-eight patients participated in the study; that is, 496 eyes: 140 eyes of 70 patients (52 women/18 men) were classified in the highly myopic group (refraction measured in spherical equivalent [RMSE]>-6D), and 356 eyes of 178 patients (98 women/80 men) in the control group (RMSE≤-6D)...
September 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28842942/risk-factors-of-age-related-cataract-in-a-chinese-adult-population-the-taizhou-eye-study
#17
Yating Tang, Xiaofeng Wang, Jiucun Wang, Li Jin, Wei Huang, Yi Luo, Yi Lu
IMPORTANCE: Cataract risk factors data will provide epidemic evidence for cataract prevention. BACKGROUND: To study the risk factors for age-related cataract (ARC) in a Chinese adult population. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: 10,234 eligible subjects ≥45 years old (response rate 78.1%). METHODS: We conducted detailed eye examinations including presenting visual acuity (PVA), best-corrected visual acuity (BCVA), slit lamp examination of lens opacities and fundus examination...
August 25, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28837730/a-novel-potentially-causative-variant-of-ndufaf7-revealed-by-mutation-screening-in-a-chinese-family-with-pathologic-myopia
#18
Baojiang Wang, Yongli Liu, Shiguo Chen, Yunmiao Wu, Sheng Lin, Yongheng Duan, Kaifeng Zheng, Linghua Zhang, Xueying Gu, Wenxu Hong, Hao Shao, Xuchun Zeng, Bi Sun, Shan Duan
Purpose: Pathologic myopia described as myopia accompanied by severe deformation of the eye besides excessive elongation of eye, is usually a genetic heterogeneous disorder characterized by extreme, familial, early-onset vision loss. However, the exact pathogenesis of pathologic myopia remains unclear. In this study, we screened a Han Chinese family with pathologic myopia to identify the causative mutation and explore the possible pathogenic mechanism based on evaluation of the biological functions of the mutation...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28828390/comparison-between-toric-and-spherical-phakic-intraocular-lenses-combined-with-astigmatic-keratotomy-for-high-myopic-astigmatism
#19
Lin-Yan Zheng, Shuang-Qian Zhu, Yan-Feng Su, Hu-Yong Zou, Qin-Mei Wang, A-Yong Yu
BACKGROUND: To compare the outcomes of a toric phakic intraocular lens (PIOL) and a spherical PIOL combined with astigmatic keratotomy (AK) for the correction of high myopic astigmatism. METHODS: This study enrolled patients with high myopic astigmatism, including 30 eyes (22 patients) that received a toric PIOL implantation (TICL group), and 32 eyes (24 patients) that received combined AK and a spherical PIOL implantation (AK+ ICL group). The outcomes were compared between the two groups before surgery, and at the following time points after surgery: 1 week, 1, 3, 6 months, and 1, 2 years...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28808644/the-comparative-study-of-refractive-index-variations-between-haigis-srk-t-and-hoffer-q-formulas-used-for-preoperative-biometry-calculation-in-patients-with-the-axial-length-25-mm
#20
Hasan Razmjoo, Hosein Atarzadeh, Neda Kargar, Mohammad Behfarnia, Kobra Nasrollahi, Ali Kamali
BACKGROUND: To compare refractive index variation between Hoffer-Q, Haigis and SRK/T formulas used for preoperative biometry calculation in patients with axial length >25 mm, undergoing cataract surgery. MATERIALS AND METHODS: This is a randomized clinical trial study was performed on 54 eyes of 54 patients with ages of 40-70 years old and axial length >25 mm classified into three groups that their IOL POWER were calculated by Haigis, SRK/T and Hoffer-Q formulas before undergoing cataract surgery...
2017: Advanced Biomedical Research
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