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https://www.readbyqxmd.com/read/28525563/omics-biomarkers-in-ophthalmology
#1
Susette Lauwen, Eiko K de Jong, Dirk J Lefeber, Anneke I den Hollander
"Omics" refers to high-throughput analyses of genes, proteins, or metabolites in a biological system, and is increasingly used for ophthalmic research. These system-based approaches can unravel disease-related processes and are valuable for biomarker discovery. Furthermore, potential therapeutic targets can be identified based on omics results, and targeted follow-up experiments can be designed to gain molecular understanding of the disease and to test new therapies. Here, we review the application of omics techniques in eye diseases, focusing on age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal detachment (RD), myopia, glaucoma, Fuchs' corneal dystrophy (FCD), cataract, keratoconus, and dry eyes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28524141/-risk-of-senile-cataract-among-nuclear-industry-workers
#2
E V Bragin, T V Azizova, M V Bannikova
AIM: to assess the relative risk (RR) of senile cataract in a cohort of workers occupationally exposed to external gamma-rays over a long time period. MATERIAL AND METHODS: The RR of cataract development was studied in a cohort of nuclear workers that were first employed in 1948-1982 and followed up till the end of 2008 (n=22,377; females, 25.4%). The mean age at initial employment was 24.9 years. The mean cumulative gamma-ray dose was 0.54 Sv in males and 0.44 Sv in females...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28516000/role-of-a-dual-splicing-and-amino-acid-code-in-myopia-cone-dysfunction-and-cone-dystrophy-associated-with-l-m-opsin-interchange-mutations
#3
Scott H Greenwald, James A Kuchenbecker, Jessica S Rowlan, Jay Neitz, Maureen Neitz
PURPOSE: Human long (L) and middle (M) wavelength cone opsin genes are highly variable due to intermixing. Two L/M cone opsin interchange mutants, designated LIAVA and LVAVA, are associated with clinical diagnoses, including red-green color vision deficiency, blue cone monochromacy, cone degeneration, myopia, and Bornholm Eye Disease. Because the protein and splicing codes are carried by the same nucleotides, intermixing L and M genes can cause disease by affecting protein structure and splicing...
May 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28514829/does-hofstetter-s-equation-predict-the-real-amplitude-of-accommodation-in-children
#4
Hassan Hashemi, Payam Nabovati, Mehdi Khabazkhoob, Abbasali Yekta, Mohammad Hassan Emamian, Akbar Fotouhi
PURPOSE: The aim was to determine the distribution and associated factors of accommodative amplitude (AA) in six- to 12-year-old children and compare the results with those calculated using Hofstetter's formula. METHODS: In a cross-sectional study in 2015, random sampling was done from urban and rural populations of Shahroud, northern Iran. Participating schoolchildren were examined for manifest, cycloplegic and subjective refraction, as well as uncorrected vision and visual acuity...
May 17, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28510775/progression-of-high-anisometropia-in-children
#5
Rasha H Zedan, Dina El-Fayoumi, Ahmed Awadein
PURPOSE: To investigate the onset and rate of progression of high anisometropia in myopic children younger than 13 years. METHODS: A retrospective study was performed on children with anisometropia younger than 13 years with myopia of more than 4.00 diopters (D) in the more ametropic eye and a difference in spherical equivalent refraction of 4.00 D between both eyes. All children had a complete ophthalmologic examination, including measurement of visual acuity and cycloplegic refraction every 3 to 6 months for at least 5 years...
May 15, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28503855/mechanical-optic-neuropathy-in-high-myopia
#6
Georgios Bontzos, Sotiris Plainis, Efrosini Papadaki, Trisevgeni Giannakopoulou, Efstathios Detorakis
No abstract text is available yet for this article.
May 14, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28503438/comparison-of-visual-effects-of-fs-lasik-for-myopia-centered-on-the-coaxially-sighted-corneal-light-reflex-or-the-line-of-sight
#7
Jing Zhang, Shi-Sheng Zhang, Qin Yu, Jing-Cai Lian
AIM: To compare visual quality after femtosecond laser in situ keratomileusis (FS-LASIK), between the coaxially sighted corneal light reflex (CSCLR) group and conventional ablation line of sight (LOS) group. METHODS: In total, 243 eyes (122 patients) were treated with centration on the CSCLR (visual axis) and 238 eyes (119 patients) treated with centration on the pupil center (LOS). Postoperative outcomes [uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA)], safety index, efficacy index, refractive outcome, ablation center distance from the visual axis, corneal high-order aberrations, subjective discomfort glare and shadowing incidence rate, and contrast sensitivity at 1, 3, and 6mo were measured and compared...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28503431/a-pilot-study-of-intraocular-lens-explantation-in-69-eyes-in-chinese-patients
#8
Fang Chai, Bo Ma, Xin-Guang Yang, Juan Li, Mei-Fang Chu
AIM: To study the effects of intraocular lens (IOL) explantation and demographic characteristics. METHODS: Retrospective non-comparative case series. Clinical data recorded from patient charts included the following: demographic, preoperative and postoperative characteristics; complications; surgical methods, and changes in visual acuity. RESULTS: A total of 69 eyes in 67 Chinese patients who received IOL explants were studied. The patients' mean age at the time of explantation was 46...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28498851/myopia-and-depressive-symptoms-among-older-chinese-adults
#9
Yin Wu, Qinghua Ma, Hong-Peng Sun, Yong Xu, Mei-E Niu, Chen-Wei Pan
PURPOSE: Few population-based data support the hypothesis that refractive errors are associated with depressive symptoms. We aim to assess the impact of myopia on the risk of having depressive symptoms in a community-based cohort of elderly Chinese. METHODS: A community-based cross-sectional study of 4611 Chinese adults aged 60 years or older was conducted. Depressive symptoms were measured using the 9-item Patient Health Questionnaire (PHQ-9) depression scale in 4597 adults...
2017: PloS One
https://www.readbyqxmd.com/read/28494561/-observation-of-single-layered-inverted-internal-limiting-membrane-flap-technique-for-macular-hole-with-retinal-detachment-in-high-myopia
#10
C Z Xu, J H Wu, J W He, C Feng
Objective: To compare the outcome of pars plana vitrectomy (PPV) with a single-layered inverted internal limiting membrane (ILM) flap versus PPV with ILM peeling for the treatment of macular hole associated retinal detachment (MHRD) in high myopia. Methods: In a retrospective cohort study, PPV with 2 kinds of adjuvant surgical procedures were used in 35 moderately high myopia eyes with MHRD. These eyes were divided into 2 groups: group 1 (17 eyes) receiving PPV and ILM peeling and group 2 (18 eyes) receiving PPV with a single-layered inverted ILM flap...
May 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28494063/efficacy-and-adverse-effects-of-atropine-in-childhood-myopia-a-meta-analysis
#11
Qianwen Gong, Miroslaw Janowski, Mi Luo, Hong Wei, Bingjie Chen, Guoyuan Yang, Longqian Liu
Importance: Some uncertainty about the clinical value and dosing of atropine for the treatment of myopia in children remains. Objective: To evaluate the efficacy vs the adverse effects of various doses of atropine in the therapy for myopia in children. Data Sources: Data were obtained from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials, from inception to April 30, 2016. The reference lists of published reviews and clinicaltrials...
May 11, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28492871/risk-factors-for-posterior-subcapsular-cataract-in-retinitis-pigmentosa
#12
Kohta Fujiwara, Yasuhiro Ikeda, Yusuke Murakami, Jun Funatsu, Shunji Nakatake, Takashi Tachibana, Noriko Yoshida, Shintaro Nakao, Toshio Hisatomi, Shigeo Yoshida, Takeshi Yoshitomi, Tatsuro Ishibashi, Koh-Hei Sonoda
Purpose: Posterior subcapsular cataract (PSC) is a frequent complication in patients with retinitis pigmentosa (RP). The risk factors for PSC formation in RP are largely unknown. The purpose of this study was to investigate the risk factors for PSC. Methods: We retrospectively studied a total of 322 eyes of 173 patients who were diagnosed with typical RP. We considered the following possible risk factors for PSC: age, sex, hypertension, diabetes mellitus, high myopia, asthma, history of steroid intake, and aqueous flare...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28491229/-anti-vegf-therapy-for-juxtafoveolar-choroidal-neovessels-in-people-with-high-myopia-about-a-case
#13
Moulay Omar Moustaine, Foued Dellali, Abbas El Husseini, Anne-Lise Hirsch
Choroidal neovessels are a threatening complication of high myopia, accounting for 5 to 10% of cases. They require immediate treatment because of their poor prognosis. Anti-VEGF intravitreal injections are currently a new therapeutic alternative far exceeding photodynamic therapy (PDT). Nevertheless, anti-VEGF treatment algorithm for this type of neovessels remains a matter of discussion among the authors. The purpose of this study was to highlight the difficulties in managing these neovessels and to discuss the Anti-VEGF therapeutic regimen to follow...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28488622/family-with-ehlers-danlos-syndrome-combined-classic-and-vascular-type-with-rare-presentation-of-progressive-myopathy-and-unusual-association-of-severe-facial-and-trigeminal-motor-weakness
#14
A Nalini, N Devaraddi, N Gayathri, Chandrajit Prasad, V Preethish-Kumar, K Polavarapu, S Shantanu
We report the clinical, radiological, biochemical, muscle histology, and electron microscopic features of two members of a family with combined Ehlers-Danlos syndrome (EDS) [classic and vascular type] and progressive myopathy as the primary manifestation. A 35-year old lady presented with severe gluteal and thigh muscle pain and easy fatigability for 5 years. She developed weakness and wasting of pelvic and pectoral girdles and thighs for 3 years and severe neck flexor and truncal weakness for 6 months. She had a history of recurrent jaw dislocation, easy bruising with hyperpigmentation, hyperextensibility of joints, translucent skin, and papyraceous scars...
May 2017: Neurology India
https://www.readbyqxmd.com/read/28486732/phake-intraokularlinsen
#15
Fritz H Hengerer, Ina Conrad-Hengerer
Implanting phakic IOLs (PIOLs) in phakic eyes is regarded as an established option in refractive surgery for many years when treating high myopia, hyperopia or ametropia. Even for eyes which show a combination of refractive errors (including astigmatism) this can be an appropriate option. The surgery itself requires certain anatomical and refractive requirements, since, as with any intraocular procedure, there are different possibilities of complication depending on the chosen IOL. Therefore, any potential candidate for refractive surgery should be treated in accordance with the current recommendations of the German "Commission Refractive Surgery" (KRC) to achieve the best possible refractive outcome with maximum safety for patient and surgeon...
May 9, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28486727/as-oct-as-a-rescue-tool-during-difficult-lenticule-extraction-in-smile
#16
Jeewan S Titiyal, Anubha Rathi, Manpreet Kaur, Ruchita Falera
PURPOSE: To report a case of lenticule adherent to the anterior cap during small incision lenticule extraction (SMILE) and its subsequent management aided by anterior segment optical coherence tomography (AS-OCT). METHODS: Case report. RESULTS: A 24-year-old woman presented with high myopia of -8.00 -0.50 @ 180° in the right eye and -8.00 -0.25 @ 180° in the left eye and underwent SMILE. In the right eye, difficulty was experienced in separating the lenticule from adjacent stroma...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28484309/identification-of-seven-novel-znf469-mutations-in-keratoconus-patients-in-a-han-chinese-population
#17
Xiaoning Yu, Binbin Chen, Xin Zhang, Xingchao Shentu
PURPOSE: To test for the potential presence of novel mutations in the zinc finger protein (ZNF469) gene in patients with sporadic keratoconus (KC) from a Han Chinese population. METHODS: Fifty-three patients with primary KC, 30 patients with high myopia (HM), and 100 unrelated population-matched healthy controls without any ocular or systemic disorders, all of Han Chinese ethnicity, were recruited. Blood samples were donated, and genomic DNA was isolated from peripheral blood leukocytes...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28482825/effect-of-limbal-relaxing-incisions-during-implantable-collamer-lens-surgery
#18
Zhen Li, Yu Han, Budan Hu, Huibin Du, Gengsheng Hao, Xiaoxi Chen
BACKGROUND: The limbal relaxing incisions (LRIs) technique is a safe and an inexpensive procedure, which is simple for experts to perform. It can effectively reduce astigmatism and result in a rapid visual rehabilitation. But there are few reports about reducing pre-existing corneal astigmatism by LRI in ICL surgery. Our research was aimed to study the effect of limbal relaxing inci sions during implantable collamer lens (ICL) surgery. METHODS: A prospective analysis reviewing consecutive cases of corneal astigmatism that had either independent ICL surgery (control group) or combined with LRIs (LRIs group)...
May 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28481929/horizontal-and-vertical-optic-disc-rotation-the-beijing-eye-study
#19
Yuan Yuan Fan, Jost B Jonas, Ya Xing Wang, Chang Xi Chen, Wen Bin Wei
PURPOSE: To measure the optic disc rotation around the vertical and horizontal disc axis and to evaluate associations with general and ocular parameters. DESIGN: Population-based study. METHODS: In the Beijing Eye Study, 3468 participants (mean age:64.6±9.8 years; range:50-93 years) underwent an ophthalmological examination which included spectral-domain optical coherence tomography (OCT) with enhanced depth imaging. Using the OCT images, we determined the amount of the rotation of the optic disc (defined as Bruch´s membrane opening (BMO)) around the vertical axis and horizontal axis...
2017: PloS One
https://www.readbyqxmd.com/read/28448294/macular-ganglion-cell-and-retinal-nerve-fiber-layer-thickness-in-children-with-refractive-errors-an-optical-coherence-tomography-study
#20
Jody P Goh, Victor Koh, Yiong Huak Chan, Cheryl Ngo
PURPOSE: To study the distribution of macular ganglion cell-inner plexiform layer (GC-IPL) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in children with refractive errors. MATERIALS AND METHODS: Two hundred forty-three healthy eyes from 139 children with refractive error ranging from -10.00 to +5.00 D were recruited from the National University Hospital Eye Surgery outpatient clinic. After a comprehensive ocular examination, refraction, and axial length (AL) measurement (IOLMaster), macular GC-IPL and RNFL thickness values were obtained with a spectral domain Cirrus high definition optical coherence tomography system (Carl Zeiss Meditec Inc...
April 26, 2017: Journal of Glaucoma
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