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https://www.readbyqxmd.com/read/28100480/detection-of-posterior-vortex-veins-in-eyes-with-pathologic-myopia-by-ultra-widefield-indocyanine-green-angiography
#1
Muka Moriyama, Kejia Cao, Satoko Ogata, Kyoko Ohno-Matsui
AIMS: To analyse the characteristics of posterior vortex veins detected in highly myopic eyes by wide-field indocyanine green angiography (ICGA). METHODS: One hundred and fifty-eight consecutive patients (302 eyes) with high myopia (myopic refractive error >8.0 dioptres (D) or axial length ≥26.5 mm) were studied. Wide-field ICGA was performed with the Spectralis HRA module. RESULTS: Posterior vortex veins were found in 80 eyes (26%)...
January 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28094579/expression-profile-of-the-integrin-receptor-subunits-in-the-guinea-pig-sclera
#2
Kevin K Wang, Ravikanth Metlapally, Christine F Wildsoet
PURPOSE: The ocular dimensional changes in myopia reflect increased scleral remodeling, and in high myopia, loss of scleral integrity leads to biomechanical weakening and continued scleral creep. As integrins, a type of cell surface receptors, have been linked to scleral remodeling, they represent potential targets for myopia therapies. As a first step, this study aimed to characterize the integrin subunits at the messenger RNA level in the sclera of the guinea pig, a more recently added but increasingly used animal model for myopia research...
January 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28092397/update-on-orthokeratology-in-managing-progressive-myopia-in-children-efficacy-mechanisms-and-concerns
#3
Xintong Li, Ilana B Friedman, Norman B Medow, Cheng Zhang
Myopia is an important public health issue, and high myopia may lead to severe complications if left untreated. Orthokeratology lenses, worn overnight to reshape the cornea, are one of many recent modalities used to slow down the progression of myopia in children. This treatment has been proven successful, as evidenced by decreased spherical refractive error and axial length relative to the control at interval follow-up ranging from 6 months to 5 years. In this systematic review, the authors collected published controlled studies that analyzed the efficacy of orthokeratology lens wear and calculated longitudinal relative changes in axial length, revealing a weighted average of -45...
January 13, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28086913/correction-of-irregular-and-induced-regular-corneal-astigmatism-with-toric-iol-after-posterior-segment-surgery-a-case-series
#4
Bence L Kolozsvári, Gergely Losonczy, Dorottya Pásztor, Mariann Fodor
BACKGROUND: Toric intraocular lens (IOL) implantation can be an effective method for correcting corneal astigmatism in patients with vitreoretinal diseases and cataract. Our purpose is to report the outcome of toric IOL implantation in two cases - a patient with scleral-buckle-induced regular corneal astigmatism and a patient with keratoconus following pars plana vitrectomy. As far as we are aware, there are no reported cases of toric IOL implantation in a vitrectomized eye with keratoconus nor of toric IOL implantation in patients with scleral-buckle-induced regular corneal astigmatism...
January 13, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28073689/corneo-scleral-contact-lens-in-a-piggyback-system-for-keratoconus-a-case-report
#5
Esteban Porcar, Juan Carlos Montalt, Enrique España-Gregori, Cristina Peris-Martínez
PURPOSE: We describe a case of fitting a corneo-scleral contact lens with a multi-aspheric geometry design (MAGD CScL) on top of a daily silicone hydrogel lens (piggyback system) for keratoconus management. METHODS: A 48-year-old man using soft toric contact lenses required an improvement in the unsatisfactory quality of his vision. He presented with bilateral asymmetric keratoconus with high myopia in the right eye (RE) and severe myopia in the left eye (LE). In addition, he had low vision in his LE because of a maculopathy...
January 7, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28058167/isolated-microspherophakia-presenting-with-angle-closure-glaucoma
#6
Tülay Şimşek, Emrullah Beyazyıldız, Enver Şimşek, Faruk Öztürk
We report a case of 13-year-old girl presenting to our clinic with blurred vision in both eyes. Ophthalmic examination revealed high myopia and angle-closure glaucoma due to pupillary block caused by small, spherical crystalline lenses. Treatment approaches to glaucoma in patients with microspherophakia are discussed in this case report.
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28058160/long-term-results-of-small-incision-lenticule-extraction-in-high-myopia
#7
Yusuf Yıldırım, Cengiz Alagöz, Abdülvahit Demir, Onur Ölçücü, Mehmet Özveren, Alper Ağca, Engin Bilge Özgürhan, Ahmet Demirok
OBJECTIVES: To evaluate two-year results of small-incision lenticule extraction (SMILE) for correction of high myopia. MATERIALS AND METHODS: Forty-five eyes of 35 patients with mean spherical equivalent (SE) of -7.10±0.95 D who underwent routine SMILE by a single surgeon and were followed for at least 2 years were analyzed by retrospective chart review. SMILE was performed with a Visumax femtosecond laser (Carl Zeiss Meditec, Jena, Germany). Follow-up intervals were at 1, 6, 12, and 24 months after surgery...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28058149/surgical-indications-and-clinical-results-of-patients-with-exchanged-intraocular-lenses-in-a-tertiary-eye-hospital
#8
Sevim Kavuncu, Aslıhan Esra Omay, Mehmet Hakan Tırhış, Pelin Yılmazbaş
OBJECTIVES: To evaluate the demographics, surgical indications and clinical results of patients with repositioned or explanted intraocular lens (IOL) in a tertiary referral eye hospital. MATERIALS AND METHODS: Forty-eight eyes of 48 patients that underwent surgery to exchange or reposition the IOL at Ulucanlar Eye Training and Research Hospital between 2009 and 2013 were included in the study. Medical records of patients were evaluated for surgical indications, time elapsed since initial operation, preoperative and postoperative best corrected distance visual acuity and the presence of ocular disease...
August 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057151/-progress-in-research-of-association-between-myopia-and-sunlight-exposure-in-children
#9
L L Zhai, X Y Wu, S J Xu, F B Tao
Myopia has become a major health problem on global scale due to its increasing high prevalence in the past few decades and gradual younger onset age. Accumulated epidemiological surveys have shown that decreased time of exposure to sunlight would be an inducement for the development of myopia. Increasing time spent outdoors and exposure to sunlight might be the most cost-effective and effective measure for children to prevent myopia. This paper summarizes the progress in research of the association between sunlight exposure and myopia in children and its mechanisms to provide new clues for the research on myopia prevention and control...
November 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28055099/evaluation-of-therapeutic-tissue-crosslinking-txl-for-myopia-using-second-harmonic-generation-signal-microscopy-in-rabbit-sclera
#10
Mariya Zyablitskaya, Anna Takaoka, Emilia L Munteanu, Takayuki Nagasaki, Stephen L Trokel, David C Paik
Purpose: Second harmonic generation signals (SHG) are emitted preferentially from collagenous tissue structures and have been used to evaluate photochemically-induced (CXL) crosslinking changes in the cornea. Since therapeutic tissue crosslinking (TXL) using sodium hydroxymethylglycinate (SMG) of the sclera is a potential treatment for high myopia, we explored the use of SHG microscopy to evaluate the effects. Methods: Single sub-Tenon's (sT) injections (400 μL) using SMG (40-400 mM) were made at the equatorial 12 o'clock position of the right eye of cadaveric rabbit heads (n = 16 pairs)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28051986/wavefront-guided-versus-wavefront-optimized-photorefractive-keratectomy-visual-and-military-task-performance
#11
Denise S Ryan, Rose K Sia, Richard D Stutzman, Joseph F Pasternak, Robin S Howard, Christopher L Howell, Tana Maurer, Mark F Torres, Kraig S Bower
PURPOSE: To compare visual performance, marksmanship performance, and threshold target identification following wavefront-guided (WFG) versus wavefront-optimized (WFO) photorefractive keratectomy (PRK). METHODS: In this prospective, randomized clinical trial, active duty U.S. military Soldiers, age 21 or over, electing to undergo PRK were randomized to undergo WFG (n = 27) or WFO (n = 27) PRK for myopia or myopic astigmatism. Binocular visual performance was assessed preoperatively and 1, 3, and 6 months postoperatively: Super Vision Test high contrast, Super Vision Test contrast sensitivity (CS), and 25% contrast acuity with night vision goggle filter...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28041966/different-roles-of-retinal-dopamine-in-albino-guinea-pig-myopia
#12
Junfeng Mao, Shuangzhen Liu
PURPOSE: To investigate whether the different role of ocular dopamine was involved in the myopic development between spontaneous myopia (SM) and form deprivation myopia (FDM) in albino guinea pigs. METHODS: 55 myopic animals were randomly divided into SM, Levodapa (L-DOPA), L-DOPA+carbidopa and vehicle. 70 non-myopic animals were randomly divided into normal control, FDM, L-DOPA+FDM, L-DOPA+carbidopa+FDM and vehicle. Once per day, for 14days, L-DOPA (10mg/kg) was injected intraperitoneally, and carbidopa (1μg) was injected at the same time into the peribulbar space of the right eye...
December 29, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28030593/identifying-children-at-risk-of-high-myopia-using-population-centile-curves-of-refraction
#13
Yanxian Chen, Jian Zhang, Ian G Morgan, Mingguang He
PURPOSE: To construct reference centile curves of refraction based on population-based data as an age-specific severity scale to evaluate their efficacy as a tool for identifying children at risk of developing high myopia in a longitudinal study. METHODS: Data of 4218 children aged 5-15 years from the Guangzhou Refractive Error Study in Children (RESC) study, and 354 first-born twins from the Guangzhou Twin Eye Study (GTES) with annual visit were included in the analysis...
2016: PloS One
https://www.readbyqxmd.com/read/28027276/accommodation-and-phoria-in-children-wearing-multifocal-contact-lenses
#14
Celia R Gong, David Troilo, Kathryn Richdale
PURPOSE: To determine the effect of multifocal contact lenses on accommodation and phoria in children. METHODS: This was a prospective, non-dispensing, randomized, crossover, single-visit study. Myopic children with normal accommodation and binocularity and no history of myopia control treatment were enrolled and fitted with CooperVision Biofinity single vision (SV) and multifocal (MF, +2.50D center distance add) contact lenses. Accommodative responses (photorefraction) and phorias (modified Thorington) were measured at four distances (>3 m, 100 cm, 40 cm, 25 cm)...
December 23, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28018693/stickler-syndrome-type-1-with-short-stature-and-atypical-ocular-manifestations
#15
Manisha Goyal, Seema Kapoor, Shiro Ikegawa, Gen Nishimura
Stickler syndrome or hereditary progressive arthroophthalmopathy is a heterogeneous group of collagen tissue disorders, characterized by orofacial features, ophthalmological features (high myopia, vitreoretinal degeneration, retinal detachment, and presenile cataracts), hearing impairment, mild spondyloepiphyseal dysplasia, and/or early onset arthritis. Stickler syndrome type I (ocular form) is caused by mutation in the COL2A1 gene. Ptosis and uveitis are relatively rare ophthalmological manifestations of this syndrome...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28005433/combined-special-capsular-tension-ring-and-toric-iol-implantation-for-management-of-astigmatism-and-high-axial-myopia-with-cataracts
#16
Yang Zhao, Jiaxin Li, Ke Yang, Xiao Li, Siquan Zhu
AIM: This study aimed to compare the effects of toric intraocular lens (IOL) implantation with a capsular tension ring and toric IOL implantation only in patients with axial myopic astigmatism who had undergone cataract surgery. METHODS: Of 34 patients with axial myopia, 16 patients who had received IOL and capsular tension ring (CTR) implantation were included in the combined group and 18 patients who received toric IOL implantation only were included in the simple group...
December 22, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28003739/visual-aberrometric-photic-phenomena-and-patient-satisfaction-after-myopic-wavefront-guided-lasik-using-a-high-resolution-aberrometer
#17
Sarah Moussa, Alois K Dexl, Eva M Krall, Eva M Arlt, Günther Grabner, Josef Ruckhofer
PURPOSE: The purpose of this study was to evaluate the visual, refractive, and aberrometric outcomes as well as the level of patient satisfaction and photic phenomena after myopic laser in situ keratomileusis (LASIK) surgery using wavefront-guided (WFG) ablations based on measurements obtained with a high-resolution aberrometer. PATIENTS AND METHODS: This study was a prospective analysis including 253 eyes of 127 patients (aged between 19 years and 54 years) undergoing WFG LASIK using the STAR S4 IR Excimer Laser System combined with the iDesign System and iFS Femtosecond Laser...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27995965/identification-of-novel-x-linked-gain-of-function-rpgr-orf15-mutation-in-italian-family-with-retinitis-pigmentosa-and-pathologic-myopia
#18
Francesco Parmeggiani, Vanessa Barbaro, Katia De Nadai, Enrico Lavezzo, Stefano Toppo, Marzio Chizzolini, Giorgio Palù, Cristina Parolin, Enzo Di Iorio
The aim of this study was to describe a new pathogenic variant in the mutational hot spot exon ORF15 of retinitis pigmentosa GTPase regulator (RPGR) gene within an Italian family with X-linked retinitis pigmentosa (RP), detailing its distinctive genotype-phenotype correlation with pathologic myopia (PM). All members of this RP-PM family underwent a complete ophthalmic examination. The entire open reading frames of RPGR and retinitis pigmentosa 2 genes were analyzed by Sanger sequencing. A novel frame-shift mutation in exon ORF15 of RPGR gene (c...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27984549/gore-tex-vascular-graft-for-macular-buckling-in-high-myopia-eyes
#19
Pei-Chang Wu, Jiunn-Jye Sheu, Yi-Hao Chen, Yung-Jen Chen, Chih-Hsin Chen, Jong-Jer Lee, Chih-Ling Huang, Chueh-Tan Chen, Hsi-Kung Kuo
PURPOSE: To evaluate a new application of an expanded polytetrafluoroethylene (Gore-Tex) vascular graft for use in macular buckling surgery for treatment of highly myopic eyes. METHODS: The Gore-Tex vascular graft was used as a macular buckling material in eight consecutive cases of myopic macular diseases which included fovea detachment, foveoschisis, or macular hole retinal detachment. RESULTS: Retinal reattachment was achieved in all cases except one which had partial resolution (88%)...
December 14, 2016: Retina
https://www.readbyqxmd.com/read/27959948/effects-of-constant-flickering-light-on-refractive-status-5-ht-and-5-ht2a-receptor-in-guinea-pigs
#20
Bing Li, Xiumei Luo, Tao Li, Changyue Zheng, Shunmei Ji, Yuanyuan Ma, Shuangshuang Zhang, Xiaodong Zhou
PURPOSE: To investigate the effects of constant flickering light on refractive development, the role of serotonin (i.e.5-hydroxytryptamine, 5-HT)and 5-HT2A receptor in myopia induced by flickering light in guinea pigs. METHODS: Forty-five guinea pigs were randomly divided into three groups: control, form deprivation myopia (FDM) and flickering light induced myopia (FLM) groups(n = 15 for each group). The right eyes of the FDM group were covered with semitransparent hemispherical plastic shells serving as eye diffusers...
2016: PloS One
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