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High myopia

Sara Salime, Zied Riahi, Soukaina Elrharchi, Lamiae Elkhattabi, Hicham Charoute, Halima Nahili, Hassan Rouba, Mostafa Kabine, Crystel Bonnet, Christine Petit, Abdelhamid Barakat
Deafness and myopia syndrome is characterized by moderate-profound, bilateral, congenital or prelingual deafness and high myopia. Autosomal recessive non-syndromic hearing loss is one of the most prevalent human genetic sensorineural defects. Myopia is by far the most common human eye disorder that is known to have a clear heritable component. The analysis of the two exons of SLITRK6 gene in a Moroccan family allowed us to identify a novel single deleterious mutation c.696delG, p.Trp232Cysfs*10 at homozygous state in the exon 2 of the SLITRK6, a gene reported to cause deafness and myopia in various populations...
March 15, 2018: Gene
Lauren G Gabra, Samir I Sayegh
This study develops a method to determine toricity ratios used by arbitrary toric intraocular lens calculators. Access to this information allows for the improvement of refractive results. We derive the Sayegh-Gabra formula, which uses input and output parameters in a toric calculator to extract toricity ratios that are typically not disclosed. We illustrate the method on a number of commercial calculators. For each calculator, high, average, and low axial length values are crossed with high, average, and low mean corneal power values to generate a 3 × 3 matrix...
March 15, 2018: Scientific Reports
Assaf Gershoni, Michael Mimouni, Eitan Livny, Irit Bahar
PURPOSE: The aim of the study was to examine the outcomes of transepithelial photorefractive keratectomy (Trans-PRK) and Femtosecond Laser-assisted in situ keratomileusis (Z-LASIK) for the correction of high myopia. METHODS: A retrospective cohort study design was used. The study group included 792 eyes with high-grade myopia (- 6.0 diopters or higher) or high-grade myopia with astigmatism that were treated with Z-LASIK or Trans-PRK in 2013 through 2014 in an optical outpatient clinic of a large private medical service...
March 12, 2018: International Ophthalmology
Mays Talib, Mary J van Schooneveld, Alberta A Thiadens, Marta Fiocco, Jan Wijnholds, Ralph J Florijn, Nicoline E Schalij-Delfos, Maria M van Genderen, Hein Putter, Frans P M Cremers, Gislin Dagnelie, Jacoline B Ten Brink, Caroline C W Klaver, L Ingeborgh van den Born, Carel B Hoyng, Arthur A Bergen, Camiel J F Boon
PURPOSE: To describe the phenotype and clinical course of patients with RPGR-associated retinal dystrophies, and to identify genotype-phenotype correlations. METHODS: A multicenter medical records review of 74 male patients with RPGR-associated retinal dystrophies. RESULTS: Patients had retinitis pigmentosa (RP; n = 52; 70%), cone dystrophy (COD; n = 5; 7%), or cone-rod dystrophy (CORD; n = 17; 23%). The median follow-up time was 11.6 years (range 0-57...
March 8, 2018: Retina
Dong Hyun Lee, Jong Wook Han, Sung Soo Kim, Suk Ho Byeon, Hyoung Jun Koh, Sung Chul Lee, Min Kim
PURPOSE: To determine the long-term effect of scleral encircling on the progression of myopia DESIGN: Retrospective, clinical cohort study METHODS: SETTING: Single-center academic hospital (Severance Hospital). STUDY POPULATION: The study included seventy-six eyes of 38 patients (mean age 37.21 ± 15.76) who have undergone retinal detachment surgery with scleral encircling OBSERVATIONAL PROCEDURES: Axial length was measured preoperatively, at 6 months after surgery, and at the most recent visit...
March 8, 2018: American Journal of Ophthalmology
Ikhyun Jun, David Sung Yong Kang, Dan Z Reinstein, Samuel Arba-Mosquera, Timothy J Archer, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To comparatively investigate the clinical outcomes, vector parameters, and corneal aberrations of small incision lenticule extraction (SMILE) with a triple centration technique and corneal wavefront-guided transepithelial photorefractive keratectomy (PRK) for the correction of high astigmatism. METHODS: This retrospective, comparative case series study included 89 eyes (89 patients) that received treatment for myopia with high astigmatism (≥ 2.50 diopters) using SMILE with a triple centration technique (SMILE group; 45 eyes) and corneal wavefront-guided transepithelial PRK (transepithelial PRK group; 44 eyes)...
March 1, 2018: Journal of Refractive Surgery
Yu Sun, Ning Zhao, Wangyuan Liu, Miao Liu, Zizhao Ju, Jun Li, Zhen Cheng, Xingdang Liu
PURPOSE: To investigate the relationship between expression level of vesicular monoamine transporter 2 (VMAT2) and myopia, as well as the feasibility of noninvasive myopia diagnosis through imaging VMAT2 in retina by using [18 F]fluoropropyl-(+)-dihydrotetrabenazine ([18 F]FP-(+)-DTBZ). PROCEDURES: The right eyes of ten guinea pigs were deprived of vision to establish form-deprived (FD) myopia and the left eyes were untreated as the self-control eyes. The location and expression level of VMAT2 in the eyes were detected by micro-positron emission tomography (PET)/X-ray computed tomography (CT) imaging through using [18 F]FP-(+)-DTBZ...
March 8, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Shuang-Qian Zhu, An-Peng Pan, Lin-Yan Zheng, Yue Wu, An-Quan Xue
BACKGROUND/AIMS: To investigate the surgical outcomes of posterior scleral reinforcement (PSR) using genipin-cross-linked sclera to treat macular hole retinal detachment (MHRD) in highly myopic eyes. METHODS: Nineteen patients with high myopia (19 eyes) with MHRD were treated sequentially with genipin-cross-linked PSR and were followed at least for 1 year after the surgery. The best corrected visual acuity (BCVA), axial length (AL), optical coherence tomography (OCT) outcomes and the complications were evaluated...
March 8, 2018: British Journal of Ophthalmology
Zhixi Li, Yifan He, Stuart Keel, Wei Meng, Robert T Chang, Mingguang He
PURPOSE: To assess the performance of a deep learning algorithm for detecting referable glaucomatous optic neuropathy (GON) based on color fundus photographs. DESIGN: A deep learning system for the classification of GON was developed for automated classification of GON on color fundus photographs. PARTICIPANTS: We retrospectively included 48 116 fundus photographs for the development and validation of a deep learning algorithm. METHODS: This study recruited 21 trained ophthalmologists to classify the photographs...
March 2, 2018: Ophthalmology
Yu Zhang, Yue-Guo Chen
BACKGROUND: To compare the incidence of rainbow glare (RG) after femtosecond laser assisted-LASIK (FS-LASIK) using the upgraded FS200 femtosecond laser with different flap cut parameter settings. METHODS: A consecutive series of 129 patients (255 eyes) who underwent FS-LASIK for correcting myopia and/or astigmatism using upgraded WaveLight FS200 femtosecond laser with the original settings was included in group A. Another consecutive series of 129 patients (255 eyes) who underwent FS-LASIK using upgraded WaveLight FS200 femtosecond laser with flap cut parameter settings changed (decreased pulse energy, spot and line separation) was included in group B...
March 5, 2018: BMC Ophthalmology
John P Ansah, Victoria Koh, Dirk F de Korne, Steffen Bayer, Chong Pan, Jayabaskar Thiyagarajan, David B Matchar, Ecosse Lamoureux, Desmond Quek
INTRODUCTION: Singapore's ageing population is likely to see an increase in chronic eye conditions in the future. This study aimed to estimate the burden of eye diseases among resident Singaporeans stratified for age and ethnicity by 2040. MATERIALS AND METHODS: Prevalence data on myopia, epiretinal membrane (ERM), retinal vein occlusion (RVO), age macular degeneration (AMD), diabetic retinopathy (DR), cataract, glaucoma and refractive error (RE) by age cohorts and educational attainment from the Singapore Epidemiology of Eye Diseases (SEED) study were applied to population estimates from the Singapore population model...
January 2018: Annals of the Academy of Medicine, Singapore
Kuddusi Teberik, Murat Kaya
Objective: To evaluate macular choroidal thickness (CT) and retinal thickness in Turkish patients with high myopia without maculopathy and in normal subjects and to examine the association with age, axial length (AL), best corrected visual acuity (BCVA), cycloplegic refraction, and spherical equivalent (SE). Methods: This prospective study was performed between January 2015 and June 2016 in the Department of Ophthalmology, Duzce University Medical Faculty. It had 65 individuals (30 patients with high myopia, 35 healthy subjects)...
November 2017: Pakistan Journal of Medical Sciences Quarterly
Rémy Marcotte-Collard, Patrick Simard, Langis Michaud
PURPOSE: This study aims to analyze two commercial orthokeratology lens designs and compare their optical effects at the corneal level. METHODS: This is a retrospective study on subjects seeking an orthokeratology fitting for myopia management at the Université de Montréal clinic between January 2013 and August 2015. Group A included the first 64 subjects fitted with a 4-curve lens design (Paragon CRT; Paragon) who met the inclusion criteria, whereas group B included the same number of subjects fitted with a 5-curve lens design (Dreamlens; Polymer Technology, Rochester, NY)...
February 27, 2018: Eye & Contact Lens
Evelyn Li Min Tai, Jiunn Loong Ling, Eng Hui Gan, Hussein Adil, Wan-Hitam Wan-Hazabbah
AIM: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured via optical coherence tomography (OCT) between different groups of myopia severity and controls. METHODS: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction, visual field analysis and A-scan biometry. Myopic patients were classified as low myopia (LM) [spherical equivalent (SE) from greater than -0.5 D, up to -3.0 D], moderate myopia (MM; SE greater than -3...
2018: International Journal of Ophthalmology
Ahmed N Sedky, Sherine S Wahba, Maged M Roshdy, Nermeen R Ayaad
BACKGROUND: Different enhancement procedures have been suggested for reduction of residual refractive errors after SMILE. The aim of this study is to evaluate an improved cap-preserving technique for enhancement after SMILE (Re-SMILE). METHODS: A retrospective case series was conducted at Eye subspecialty center, Cairo, Egypt on 9 eyes with myopia or myopic astigmatism (spherical equivalent - 8.0 and - 12.0D). undergoing SMILE procedure and needed second interference...
February 17, 2018: BMC Ophthalmology
Lin Zhou, Xueshan Xiao, Shiqiang Li, Xiaoyun Jia, Qingjiong Zhang
In our previous study, potential pathological mutations of RetNet genes were detected in 23.8% (71/298) of probands with early-onset high myopia (eoHM), based on whole exome sequencing (WES). The current study aimed to confirm this finding in an additional 325 probands with eoHM and to clarify its specificity by comparison of 195 probands with late-onset high myopia (loHM). Variants in the 234 RetNet genes were selected from whole-exome sequencing data and were filtered using multistep bioinformatics analyses...
February 14, 2018: Experimental Eye Research
Kenji Yamashiro, Eri Kinoshita-Nakano, Toru Ota, Yoko Jingami, Isao Nakata, Hisako Hayashi
PURPOSE: To evaluate the surgical results of macular hole (MH) in patients with high myopia treated with pars plana vitrectomy (PPV) leaving the internal limiting membrane (ILM) flap floating in vitreous fluid at the edge of the MH. METHODS: Nine highly myopic eyes with MH of nine consecutive patients who underwent PPV were retrospectively evaluated. Three eyes were accompanied by retinal detachment (RD). ILM peeling was performed around the MH and some part of the ILM flap was left attached to the edge of the MH...
February 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Imen Ammous, Imène Zhioua Braham, Majdi Boukari, Ilhem Mili Boussen, Khalil Errais, Raja Zhioua
AIM: to analyse clinical and epidemiological characteristics of atrophic tear retinal detachment (ATRD) and evaluate anatomical and functional results. METHODS: Retrospective study of 48 cases underwent primary scleral buckling for ATRD. Mean follow up was 80,52 months. RESULTS: ATRD represented 7% of all reghmatogenous RD. Mean age of patients was 38 years and 7 months. Age was less than 40 years in 62,5% of patients. Male predominance was noted...
March 2017: La Tunisie Médicale
Xiaohan Wang, Mengxi Shen, Ruoshi Wang, Yanping Zhou, Tong Li, Meichun Xiao, Minlu Song, Xiaodong Sun, Fenghua Wang
PURPOSE: To observe the vitreous in highly myopic eyes with posterior precortical vitreous pockets (PPVPs) using enhanced vitreous imaging of spectral domain optical coherence tomography. METHODS: Fifty-two highly myopic eyes with PPVPs of 36 patients were included in this study. All subjects underwent enhanced vitreous imaging optical coherence tomography. The size of PPVPs was measured, and the frequency of imaging features was recorded. RESULTS: Nine imaging features of the vitreous in highly myopic eyes with PPVPs were found...
February 13, 2018: Retina
Phillippa M Cumberland, Vasiliki Bountziouka, Jugnoo S Rahi
BACKGROUND: Refractive error is an increasing global public health concern that requires robust and reliable research to identify modifiable risk factors and provide accurate estimates of population burden. We investigated the impact of reclassification of individuals when using different threshold values of spherical equivalent (SE) to define myopia, on estimates of frequency, distribution and associations with risk factors, to inform current international initiatives to standardise definitions...
February 3, 2018: British Journal of Ophthalmology
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