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McKenzie Method

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https://www.readbyqxmd.com/read/29203419/flaws-in-the-application-and-interpretation-of-statistical-analyses-in-systematic-reviews-of-therapeutic-interventions-were-common-a-cross-sectional-analysis
#1
Matthew J Page, Douglas G Altman, Joanne E McKenzie, Larissa Shamseer, Nadera Ahmadzai, Dianna Wolfe, Fatemeh Yazdi, Ferrán Catalá-López, Andrea C Tricco, David Moher
OBJECTIVES: To investigate the application and interpretation of statistical analyses in a cross-section of systematic reviews (SRs) of therapeutic interventions, without restriction by journal, clinical condition, or specialty. STUDY DESIGN AND SETTING: We evaluated a random sample of SRs assembled previously, which were indexed in MEDLINE® during February 2014, focused on a treatment or prevention question, and reported at least one meta-analysis. The reported statistical methods used in each SR were extracted from articles and online appendices by one author, with a 20% random sample extracted in duplicate...
December 1, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29199820/multimodal-probes-superresolution-and-transmission-electron-microscopy-imaging-of-mitochondria-and-oxygen-mapping-of-cells-using-small-molecule-ir-iii-luminescent-complexes
#2
Jonathan R Shewring, Ahmet J Cankut, Luke K McKenzie, Bethany J Crowston, Stanley W Botchway, Julia A Weinstein, Elizabeth Edwards, Michael D Ward
We describe an Ir(III)-based small-molecule, multimodal probe for use in both light and electron microscopy. The direct correlation of data between light- and electron-microscopy-based imaging to investigate cellular processes at the ultrastructure level is a current challenge, requiring both dyes that must be brightly emissive for luminescence imaging and scatter electrons to give contrast for electron microscopy, at a single working concentration suitable for both methods. Here we describe the use of Ir(III) complexes as probes that provide excellent image contrast and quality for both luminescence and electron microscopy imaging, at the same working concentration...
December 4, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29184298/changes-in-rounded-shoulder-posture-and-forward-head-posture-according-to-exercise-methods
#3
Do Youn Lee, Chan Woo Nam, Youn Bum Sung, Kyoung Kim, Hae Yong Lee
[Purpose] This study aimed to determine the effect of forward head posture-improving exercises on rounded shoulder posture when employing the self-stretch exercise, the McKenzie exercise, and the Kendall exercise as intervention methods based on previous studies that reported negative effects of unbalanced posture and musculoskeletal problems on forward head posture and rounded shoulder posture. [Subjects and Methods] The selected 28 subjects were randomly assigned into the McKenzie exercise group (n=9), the self-stretch exercise group (n=10), and the Kendall exercise group (n=9)...
October 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29178008/trace-metal-contamination-in-the-glacierized-rio-santa-watershed-peru
#4
Alexandre Guittard, Michel Baraer, Jeffrey M McKenzie, Bryan G Mark, Oliver Wigmore, Alfonso Fernandez, Alejo C Rapre, Elizabeth Walsh, Jeffrey Bury, Mark Carey, Adam French, Kenneth R Young
The objective of this research is to characterize the variability of trace metals in the Rio Santa watershed based on synoptic sampling applied at a large scale. To that end, we propose a combination of methods based on the collection of water, suspended sediments, and riverbed sediments at different points of the watershed within a very limited period. Forty points within the Rio Santa watershed were sampled between June 21 and July 8, 2013. Forty water samples, 36 suspended sediments, and 34 riverbed sediments were analyzed for seven trace metals...
November 25, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29162130/toward-a-comprehensive-evidence-map-of-overview-of-systematic-review-methods-paper-1-purpose-eligibility-search-and-data-extraction
#5
Carole Lunny, Sue E Brennan, Steve McDonald, Joanne E McKenzie
BACKGROUND: Overviews of systematic reviews attempt to systematically retrieve and summarise the results of multiple systematic reviews. Methods for conducting, interpreting and reporting overviews are in their infancy. To date, there has been no evidence map of the methods used in overviews, thus making it difficult to determine the gaps and priorities for methods research. Our objectives were to develop and populate a comprehensive framework of methods for conducting, interpreting and reporting overviews (stage I) and to create an evidence map by mapping studies that have evaluated overview methods to the framework (stage II)...
November 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29154522/distribution-and-evaluation-of-a-carbon-monoxide-detector-intervention-in-two-settings-emergency-department-and-urban-community
#6
Lara B McKenzie, Kristin J Roberts, Wendy C Shields, Eileen McDonald, Elise Omaki, Mahmoud Abdel-Rasoul, Andrea C Gielen
The objective of this study was to describe changes in carbon monoxide (CO) safety knowledge and observed CO detector use following distribution of a CO detector use intervention in two environments, a pediatric emergency department (Ohio) and an urban community (Maryland). A total of 301 participants completed the 6-month follow up (Ohio: n = 125; Maryland: n = 176). The majority of participants was female, 25–34 years of age, and employed (full or part time). We found that CO safety knowledge did not differ between settings at enrollment, but significantly improved at the follow-up visits...
May 2017: Journal of Environmental Health
https://www.readbyqxmd.com/read/29137812/crowdsourcing-conservation-the-role-of-citizen-science-in-securing-a-future-for-seagrass
#7
Benjamin L Jones, Richard K F Unsworth, Len J McKenzie, Rudi L Yoshida, Leanne C Cullen-Unsworth
Seagrass meadows are complex social-ecological systems. Understanding seagrass meadows demands a fresh approach integrating "the human dimension". Citizen science is widely acknowledged for providing significant contributions to science, education, society and policy. Although the take up of citizen science in the marine environment has been slow, the need for such methods to fill vast information gaps is arguably great. Seagrass meadows are easy to access and provide an example of where citizen science is expanding...
November 11, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29063861/analysis-of-time-correlated-single-photon-counting-data-a-comparative-evaluation-of-deterministic-and-probabilistic-approaches
#8
Darren A Smith, Grant McKenzie, Anita C Jones, Trevor A Smith
We review various methods for analysing time-resolved fluorescence data acquired using the time-correlated single photon counting method in an attempt to evaluate their benefits and limitations. We have applied these methods to both experimental and simulated data. The relative merits of using deterministic approaches, such as the commonly used iterative reconvolution method, and probabilistic approaches, such as the smoothed exponential series method, the maximum entropy method and recently proposed basis pursuit denoising (compressed sensing) method, are outlined...
October 24, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/29016701/modifying-alcohol-consumption-to-reduce-obesity-a-randomized-controlled-feasibility-study-of-a-complex-community-based-intervention-for-men
#9
Linda Irvine, Iain K Crombie, Kathryn B Cunningham, Brian Williams, Falko F Sniehotta, John Norrie, Ambrose J Melson, Claire Jones, Peter Rice, Peter W Slane, Marcus Achison, Andrew McKenzie, Elena D Dimova, Sheila Allan
Objectives: Being obese and drinking more than 14 units of alcohol per week places men at very high risk of developing liver disease. This study assessed the feasibility of a trial to reduce alcohol consumption. It tested the recruitment strategy, engagement with the intervention, retention and study acceptability. Methods: Men aged 35-64 years who drank >21 units of alcohol per week and had a BMI > 30 were recruited by two methods: from GP patient registers and by community outreach...
September 18, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28990860/in-a-genomic-era-placental-pathology-still-holds-the-key-in-the-nondysmorphic-stillbirth
#10
Jamie Campbell, Kristy Armstrong, Nithiya Palaniappan, Eddy Maher, Mary Glancy, Mary Porteous, Kathryn J Mckenzie, Margaret J Evans
Objective To explore the relative utility of genetic testing in contrast to placental pathology in explaining causation of death in the structurally normal stillborn population. Methods A retrospective review of a structurally normal stillborn infant cohort in South East Scotland between 2011 and 2015, defined by death at or after 24 weeks of gestation. We reviewed pathology reports and collected demographic data on cases. This information was collated with genetic test results (quantitative fluorescent polymerase chain reaction and microarray analysis) and placental pathology to create a database for analysis...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28963056/hippocampus-dependent-spatial-learning-is-associated-with-higher-global-cognition-among-healthy-older-adults
#11
Kyoko Konishi, Sam Mckenzie, Nicole Etchamendy, Shumita Roy, Véronique D Bohbot
Cognitive deficits in normal aging have been associated with atrophy of the hippocampus. As such, methods to detect early dysfunction of the hippocampus have become valuable, if not indispensable, to early intervention. The hippocampus is critical for spatial memory and is among the first structures to atrophy with aging. Despite the presence of navigation deficits in aging, few studies have looked at the association between wayfinding ability, navigation strategies, general cognitive function, and hippocampal volume...
September 28, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28928646/cortical-activation-during-action-observation-action-execution-and-interpersonal-synchrony-in-adults-a-functional-near-infrared-spectroscopy-fnirs-study
#12
Anjana N Bhat, Michael D Hoffman, Susanna L Trost, McKenzie L Culotta, Jeffrey Eilbott, Daisuke Tsuzuki, Kevin A Pelphrey
Introduction: Humans engage in Interpersonal Synchrony (IPS) as they synchronize their own actions with that of a social partner over time. When humans engage in imitation/IPS behaviors, multiple regions in the frontal, temporal, and parietal cortices are activated including the putative Mirror Neuron Systems (Iacoboni, 2005; Buxbaum et al., 2014). In the present study, we compared fNIRS-based cortical activation patterns across three conditions of action observation ("Watch" partner), action execution ("Do" on your own), and IPS (move "Together")...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28920803/assessment-of-a-lancet-and-swab-blood-sampling-technique-for-surveillance-of-elephant-endotheliotropic-herpesvirus-infection
#13
Javier Lopez, L do Vet M Sc, Jonathan Haycock, Andrew Mckenzie, Katharina Seilern-Moy, Akbar Dastjerdi
Lancing a finger elicits minimal pain in humans and is applied routinely to obtain small volumes of blood for clinical diagnostics. A modified lancet bleeding method and several blood sampling matrices were evaluated in this study for the purpose of routine elephant endotheliotropic herpesvirus (EEHV) surveillance in Asian elephants (Elephas maximus). The procedure enabled weekly sampling from elephants as young as 9 mo of age. The blood sampling matrices were evaluated for their sensitivity measuring β-actin, tumor necrosis factor α, and/or EEHV-1 by quantitative polymerase chain reaction assays...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28912004/living-systematic-reviews-3-statistical-methods-for-updating-meta-analyses
#14
Mark Simmonds, Georgia Salanti, Joanne McKenzie, Julian Elliott
A living systematic review (LSR) should keep the review current as new research evidence emerges. Any meta-analyses included in the review will also need updating as new material is identified. If the aim of the review is solely to present the best current evidence standard meta-analysis may be sufficient, provided reviewers are aware that results may change at later updates. If the review is used in a decision-making context, more caution may be needed. When using standard meta-analysis methods, the chance of incorrectly concluding that any updated meta-analysis is statistically significant when there is no effect (the type I error) increases rapidly as more updates are performed...
November 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28886726/overviews-of-systematic-reviews-great-promise-greater-challenge
#15
EDITORIAL
Joanne E McKenzie, Sue E Brennan
The proliferation of systematic reviews and escalating demand from policy makers has driven a newer form of evidence synthesis-overviews of systematic reviews. Systematic Reviews are publishing a special thematic series on overviews and are encouraging submissions on the development and evaluation of methods for this review type. The authors' of this editorial introduce the series by considering challenges that arise when conducting an overview and what methods guidance is available. They emphasise the importance of evaluating overview methods to understand the trade-offs of using different approaches and propose that a more systematic and coordinated approach to methods development would be beneficial...
September 8, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28878000/dissecting-hematopoietic-and-renal-cell-heterogeneity-in-adult-zebrafish-at-single-cell-resolution-using-rna-sequencing
#16
Qin Tang, Sowmya Iyer, Riadh Lobbardi, John C Moore, Huidong Chen, Caleb Lareau, Christine Hebert, McKenzie L Shaw, Cyril Neftel, Mario L Suva, Craig J Ceol, Andre Bernards, Martin Aryee, Luca Pinello, Iain A Drummond, David M Langenau
Recent advances in single-cell, transcriptomic profiling have provided unprecedented access to investigate cell heterogeneity during tissue and organ development. In this study, we used massively parallel, single-cell RNA sequencing to define cell heterogeneity within the zebrafish kidney marrow, constructing a comprehensive molecular atlas of definitive hematopoiesis and functionally distinct renal cells found in adult zebrafish. Because our method analyzed blood and kidney cells in an unbiased manner, our approach was useful in characterizing immune-cell deficiencies within DNA-protein kinase catalytic subunit (prkdc), interleukin-2 receptor γ a (il2rga), and double-homozygous-mutant fish, identifying blood cell losses in T, B, and natural killer cells within specific genetic mutants...
October 2, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28834049/sono-raft-polymerization-in-aqueous-medium
#17
Thomas G McKenzie, Enrico Colombo, Qiang Fu, Muthupandian Ashokkumar, Greg G Qiao
The ultrasonic irradiation of aqueous solution is demonstrated to be a suitable source of initiating radicals for a controlled radical polymerization when conducted in the presence of a thiocarbonylthio-containing reversible addition-fragmentation chain transfer (RAFT) agent. This allows for a highly "green" method of externally regulated/controlled polymerization with a potentially broad scope for polymerizable monomers and/or polymer structures.
August 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28777935/de-novo-mutations-in-ywhag-cause-early-onset-epilepsy
#18
Ilaria Guella, Marna B McKenzie, Daniel M Evans, Sarah E Buerki, Eric B Toyota, Margot I Van Allen, Mohnish Suri, Frances Elmslie, Marleen E H Simon, Koen L I van Gassen, Delphine Héron, Boris Keren, Caroline Nava, Mary B Connolly, Michelle Demos, Matthew J Farrer
Massively parallel sequencing has revealed many de novo mutations in the etiology of developmental and epileptic encephalopathies (EEs), highlighting their genetic heterogeneity. Additional candidate genes have been prioritized in silico by their co-expression in the brain. Here, we evaluate rare coding variability in 20 candidates nominated with the use of a reference gene set of 51 established EE-associated genes. Variants within the 20 candidate genes were extracted from exome-sequencing data of 42 subjects with EE and no previous genetic diagnosis...
August 3, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28767239/zein-nanoparticles-uptake-and-translocation-in-hydroponically-grown-sugarcane-plants
#19
Alisha Prasad, Carlos E Astete, Andreea Elena Bodoki, McKenzie Windham, Ede Bodoki, Cristina M Sabliov
The main objective of this study was to investigate the uptake and translocation of positively charged zein nanoparticles (ZNPs) in hydroponically grown sugarcane plants. Fluorescent ZNPs (spherical and measuring an average diameter 135±3 nm) were synthesized by emulsion-diffusion method from FITC-tagged zein. Fluorescent measurement following digestion of plant tissue indicated that sugarcane roots had a significant adhesion of ZNPs, 342.5±24.2 μg NPs/mg of dry matter, while sugarcane leaves contained a very limited amount, 12...
August 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28751646/an-integrative-computational-approach-to-evaluate-genetic-markers-for-bipolar-disorder
#20
Yong Xu, Jun Wang, Shuquan Rao, McKenzie Ritter, Lydia C Manor, Robert Backer, Hongbao Cao, Zaohuo Cheng, Sha Liu, Yansong Liu, Lin Tian, Kunlun Dong, Yin Yao Shugart, Guoqiang Wang, Fuquan Zhang
Studies to date have reported hundreds of genes connected to bipolar disorder (BP). However, many studies identifying candidate genes have lacked replication, and their results have, at times, been inconsistent with one another. This paper, therefore, offers a computational workflow that can curate and evaluate BP-related genetic data. Our method integrated large-scale literature data and gene expression data that were acquired from both postmortem human brain regions (BP case/control: 45/50) and peripheral blood mononuclear cells (BP case/control: 193/593)...
July 27, 2017: Scientific Reports
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