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McKenzie Method

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https://www.readbyqxmd.com/read/29016701/modifying-alcohol-consumption-to-reduce-obesity-a-randomized-controlled-feasibility-study-of-a-complex-community-based-intervention-for-men
#1
Linda Irvine, Iain K Crombie, Kathryn B Cunningham, Brian Williams, Falko F Sniehotta, John Norrie, Ambrose J Melson, Claire Jones, Peter Rice, Peter W Slane, Marcus Achison, Andrew McKenzie, Elena D Dimova, Sheila Allan
Objectives: Being obese and drinking more than 14 units of alcohol per week places men at very high risk of developing liver disease. This study assessed the feasibility of a trial to reduce alcohol consumption. It tested the recruitment strategy, engagement with the intervention, retention and study acceptability. Methods: Men aged 35-64 years who drank >21 units of alcohol per week and had a BMI > 30 were recruited by two methods: from GP patient registers and by community outreach...
September 18, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28990860/in-a-genomic-era-placental-pathology-still-holds-the-key-in-the-nondysmorphic-stillbirth
#2
Jamie Campbell, Kristy Armstrong, Nithiya Palaniappan, Eddy Maher, Mary Glancy, Mary Porteous, Kathryn J Mckenzie, Margaret J Evans
Objective To explore the relative utility of genetic testing in contrast to placental pathology in explaining causation of death in the structurally normal stillborn population. Methods A retrospective review of a structurally normal stillborn infant cohort in South East Scotland between 2011 and 2015, defined by death at or after 24 weeks of gestation. We reviewed pathology reports and collected demographic data on cases. This information was collated with genetic test results (quantitative fluorescent polymerase chain reaction and microarray analysis) and placental pathology to create a database for analysis...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28963056/hippocampus-dependent-spatial-learning-is-associated-with-higher-global-cognition-among-healthy-older-adults
#3
Kyoko Konishi, Sam Mckenzie, Nicole Etchamendy, Shumita Roy, Véronique D Bohbot
Cognitive deficits in normal aging have been associated with atrophy of the hippocampus. As such, methods to detect early dysfunction of the hippocampus have become valuable, if not indispensable, to early intervention. The hippocampus is critical for spatial memory and is among the first structures to atrophy with aging. Despite the presence of navigation deficits in aging, few studies have looked at the association between wayfinding ability, navigation strategies, general cognitive function, and hippocampal volume...
September 26, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28928646/cortical-activation-during-action-observation-action-execution-and-interpersonal-synchrony-in-adults-a-functional-near-infrared-spectroscopy-fnirs-study
#4
Anjana N Bhat, Michael D Hoffman, Susanna L Trost, McKenzie L Culotta, Jeffrey Eilbott, Daisuke Tsuzuki, Kevin A Pelphrey
Introduction: Humans engage in Interpersonal Synchrony (IPS) as they synchronize their own actions with that of a social partner over time. When humans engage in imitation/IPS behaviors, multiple regions in the frontal, temporal, and parietal cortices are activated including the putative Mirror Neuron Systems (Iacoboni, 2005; Buxbaum et al., 2014). In the present study, we compared fNIRS-based cortical activation patterns across three conditions of action observation ("Watch" partner), action execution ("Do" on your own), and IPS (move "Together")...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28920803/assessment-of-a-lancet-and-swab-blood-sampling-technique-for-surveillance-of-elephant-endotheliotropic-herpesvirus-infection
#5
Javier Lopez, L do Vet M Sc, Jonathan Haycock, Andrew Mckenzie, Katharina Seilern-Moy, Akbar Dastjerdi
Lancing a finger elicits minimal pain in humans and is applied routinely to obtain small volumes of blood for clinical diagnostics. A modified lancet bleeding method and several blood sampling matrices were evaluated in this study for the purpose of routine elephant endotheliotropic herpesvirus (EEHV) surveillance in Asian elephants (Elephas maximus). The procedure enabled weekly sampling from elephants as young as 9 mo of age. The blood sampling matrices were evaluated for their sensitivity measuring β-actin, tumor necrosis factor α, and/or EEHV-1 by quantitative polymerase chain reaction assays...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28912004/living-systematic-reviews-3-statistical-methods-for-updating-meta-analyses
#6
REVIEW
Mark Simmonds, Georgia Salanti, Joanne McKenzie
A Living systematic review should keep the review current as new research evidence emerges. Any meta-analyses included in the review will also need updating as new material is identified.
September 1, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28886726/overviews-of-systematic-reviews-great-promise-greater-challenge
#7
EDITORIAL
Joanne E McKenzie, Sue E Brennan
The proliferation of systematic reviews and escalating demand from policy makers has driven a newer form of evidence synthesis-overviews of systematic reviews. Systematic Reviews are publishing a special thematic series on overviews and are encouraging submissions on the development and evaluation of methods for this review type. The authors' of this editorial introduce the series by considering challenges that arise when conducting an overview and what methods guidance is available. They emphasise the importance of evaluating overview methods to understand the trade-offs of using different approaches and propose that a more systematic and coordinated approach to methods development would be beneficial...
September 8, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28878000/dissecting-hematopoietic-and-renal-cell-heterogeneity-in-adult-zebrafish-at-single-cell-resolution-using-rna-sequencing
#8
Qin Tang, Sowmya Iyer, Riadh Lobbardi, John C Moore, Huidong Chen, Caleb Lareau, Christine Hebert, McKenzie L Shaw, Cyril Neftel, Mario L Suva, Craig J Ceol, Andre Bernards, Martin Aryee, Luca Pinello, Iain A Drummond, David M Langenau
Recent advances in single-cell, transcriptomic profiling have provided unprecedented access to investigate cell heterogeneity during tissue and organ development. In this study, we used massively parallel, single-cell RNA sequencing to define cell heterogeneity within the zebrafish kidney marrow, constructing a comprehensive molecular atlas of definitive hematopoiesis and functionally distinct renal cells found in adult zebrafish. Because our method analyzed blood and kidney cells in an unbiased manner, our approach was useful in characterizing immune-cell deficiencies within DNA-protein kinase catalytic subunit (prkdc), interleukin-2 receptor γ a (il2rga), and double-homozygous-mutant fish, identifying blood cell losses in T, B, and natural killer cells within specific genetic mutants...
October 2, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28834049/sono-raft-polymerization-in-aqueous-medium
#9
Thomas G McKenzie, Enrico Colombo, Qiang Fu, Muthupandian Ashokkumar, Greg G Qiao
The ultrasonic irradiation of aqueous solution is demonstrated to be a suitable source of initiating radicals for a controlled radical polymerization when conducted in the presence of a thiocarbonylthio-containing reversible addition-fragmentation chain transfer (RAFT) agent. This allows for a highly "green" method of externally regulated/controlled polymerization with a potentially broad scope for polymerizable monomers and/or polymer structures.
August 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28777935/de-novo-mutations-in-ywhag-cause-early-onset-epilepsy
#10
Ilaria Guella, Marna B McKenzie, Daniel M Evans, Sarah E Buerki, Eric B Toyota, Margot I Van Allen, Mohnish Suri, Frances Elmslie, Marleen E H Simon, Koen L I van Gassen, Delphine Héron, Boris Keren, Caroline Nava, Mary B Connolly, Michelle Demos, Matthew J Farrer
Massively parallel sequencing has revealed many de novo mutations in the etiology of developmental and epileptic encephalopathies (EEs), highlighting their genetic heterogeneity. Additional candidate genes have been prioritized in silico by their co-expression in the brain. Here, we evaluate rare coding variability in 20 candidates nominated with the use of a reference gene set of 51 established EE-associated genes. Variants within the 20 candidate genes were extracted from exome-sequencing data of 42 subjects with EE and no previous genetic diagnosis...
August 3, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28767239/zein-nanoparticles-uptake-and-translocation-in-hydroponically-grown-sugarcane-plants
#11
Alisha Prasad, Carlos E Astete, Andreea Elena Bodoki, McKenzie Windham, Ede Bodoki, Cristina M Sabliov
The main objective of this study was to investigate the uptake and translocation of positively charged zein nanoparticles (ZNPs) in hydroponically grown sugarcane plants. Fluorescent ZNPs (spherical and measuring an average diameter 135±3 nm) were synthesized by emulsion-diffusion method from FITC-tagged zein. Fluorescent measurement following digestion of plant tissue indicated that sugarcane roots had a significant adhesion of ZNPs, 342.5±24.2 μg NPs/mg of dry matter, while sugarcane leaves contained a very limited amount, 12...
August 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28751646/an-integrative-computational-approach-to-evaluate-genetic-markers-for-bipolar-disorder
#12
Yong Xu, Jun Wang, Shuquan Rao, McKenzie Ritter, Lydia C Manor, Robert Backer, Hongbao Cao, Zaohuo Cheng, Sha Liu, Yansong Liu, Lin Tian, Kunlun Dong, Yin Yao Shugart, Guoqiang Wang, Fuquan Zhang
Studies to date have reported hundreds of genes connected to bipolar disorder (BP). However, many studies identifying candidate genes have lacked replication, and their results have, at times, been inconsistent with one another. This paper, therefore, offers a computational workflow that can curate and evaluate BP-related genetic data. Our method integrated large-scale literature data and gene expression data that were acquired from both postmortem human brain regions (BP case/control: 45/50) and peripheral blood mononuclear cells (BP case/control: 193/593)...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28718453/analysis-of-tcspc-data-a-comparative-evaluation-of-deterministic-and-probabilistic-approaches
#13
Darren Andrew Smith, Grant McKenzie, Anita C Jones, Trevor Smith
We review various methods for analysing time-resolved fluorescence data acquired using the time-correlated single photon counting (TCSPC) method in an attempt to evaluate their benefits and limitations. We have applied these methods to both experimental and simulated data. The relative merits of using deterministic approaches, such as the commonly used iterative reconvolution method, and probabilistic approaches, such as the smoothed exponential series method (SESM), the maximum entropy method (MEM) and recently proposed basis pursuit denoising (BPDN, compressed sensing) method are outlined...
July 18, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28701365/mckenzie-method-of-mechanical-diagnosis-and-therapy-was-slightly-more-effective-than-placebo-for-pain-but-not-for-disability-in-patients-with-chronic-non-specific-low-back-pain-a-randomised-placebo-controlled-trial-with-short-and-longer-term-follow-up
#14
Alessandra Narciso Garcia, Lucíola da Cunha Menezes Costa, Mark J Hancock, Fabrício Soares de Souza, Geórgia Vieira Freschi de Oliveira Gomes, Matheus Oliveira de Almeida, Leonardo Oliveira Pena Costa
BACKGROUND: The McKenzie Method of Mechanical Diagnosis and Therapy (MDT) is one of the exercise approaches recommended by low back pain (LBP) guidelines. We investigated the efficacy of MDT compared with placebo in patients with chronic LBP. METHODS: This was a prospectively registered, two-arm randomised placebo controlled trial, with a blinded assessor. A total of 148 patients seeking care for chronic LBP were randomly allocated to either MDT (n=74) or placebo (n=74)...
July 12, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28675977/the-reliability-of-measuring-acetabular-component-position-on-radiographs-using-everyday-diagnostic-imaging-software
#15
Jack Lahy, Jarrad Stevens, Dean McKenzie, Richard de Steiger
BACKGROUND: It is standard practice for total hip arthroplasty (THA) patients to have post-operative imaging, and one of the reasons is to assess the adequacy of acetabular component position. Correct positioning of the acetabular component is important for successful outcome in THA. Acetabular component position can be measured from either computed tomography (CT) or plain radiographs. While CT is the gold standard for accurately measuring acetabular component position, radiographs are routinely used for post-operative evaluation...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28646922/an-investigation-of-the-impact-of-using-different-methods-for-network-meta-analysis-a-protocol-for-an-empirical-evaluation
#16
Amalia Emily Karahalios, Georgia Salanti, Simon L Turner, G Peter Herbison, Ian R White, Areti Angeliki Veroniki, Adriani Nikolakopoulou, Joanne E Mckenzie
BACKGROUND: Network meta-analysis, a method to synthesise evidence from multiple treatments, has increased in popularity in the past decade. Two broad approaches are available to synthesise data across networks, namely, arm- and contrast-synthesis models, with a range of models that can be fitted within each. There has been recent debate about the validity of the arm-synthesis models, but to date, there has been limited empirical evaluation comparing results using the methods applied to a large number of networks...
June 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28645058/promoting-physical-activity-in-high-poverty-neighborhood-parks-a-cluster-randomized-controlled-trial
#17
Deborah A Cohen, Bing Han, Kathryn P Derose, Stephanie Williamson, Terry Marsh, Laura Raaen, Thomas L McKenzie
Although physical activity can help mitigate or prevent multiple chronic diseases, most people in the U.S., especially high-poverty minority groups, engage in insufficient levels of physical activity. To test ways to promote more physical activity in high-poverty area public parks we conducted a randomized controlled intervention trial. After completing baseline measures of park-based physical activity using systematic direct observation three times/day each month for six months and assessing preferences for park programming among 1445 residents living within 1 mile of study parks, we randomized 48 parks in high poverty neighborhoods in the City of Los Angeles, California during 2013-2014 to four study arms: 1) free physical activity classes over a 6-month period, 2) a frequent user program where participants could win prizes based upon the number of visits they made to the park, 3) both the programs, and 4) neither one (control condition)...
August 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28614809/monitoring-body-water-balance-in-pregnant-and-nursing-women-the-validity-of-urine-color
#18
Amy L McKenzie, Lawrence E Armstrong
BACKGROUND: Urine osmolality (UOSM) reflects the renal regulation of excess fluid or deficit fluid, and therefore, serves as a marker of hydration status. Little is known about monitoring hydration in pregnant and lactating women despite significant physiological challenges to body water balance during that time. Therefore, we designed a study to assess if urine color (UCOL), an inexpensive and practical method, was a valid means of assessing urine concentration. Twenty-four hour UCOL was significantly correlated with 24 h UOSM in all women: pregnant, lactating, and control (r = 0...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28599897/to-the-point-medical-education-technology-and-the-millennial-learner
#19
REVIEW
Laura Hopkins, Brittany S Hampton, Jodi F Abbott, Samantha D Buery-Joyner, LaTasha B Craig, John L Dalrymple, David A Forstein, Scott C Graziano, Margaret L McKenzie, Archana Pradham, Abigail Wolf, Sarah M Page-Ramsey
This article, from the "To The Point" series that was prepared by the Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee, provides an overview of the characteristics of millennials and describes how medical educators can customize and reframe their curricula and teaching methods to maximize millennial learning. A literature search was performed to identify articles on generational learning. We summarize the importance of understanding the attitudes, ideas, and priorities of millennials to tailor educational methods to stimulate and enhance learning...
June 28, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28578592/adjunctive-minocycline-treatment-for-major-depressive-disorder-a-proof-of-concept-trial
#20
Olivia M Dean, Buranee Kanchanatawan, Melanie Ashton, Mohammadreza Mohebbi, Chee Hong Ng, Michael Maes, Lesley Berk, Atapol Sughondhabirom, Sookjaroen Tangwongchai, Ajeet B Singh, Helen McKenzie, Deidre J Smith, Gin S Malhi, Nathan Dowling, Michael Berk
OBJECTIVE: Conventional antidepressant treatments result in symptom remission in 30% of those treated for major depressive disorder, raising the need for effective adjunctive therapies. Inflammation has an established role in the pathophysiology of major depressive disorder, and minocycline has been shown to modify the immune-inflammatory processes and also reduce oxidative stress and promote neuronal growth. This double-blind, randomised, placebo-controlled trial examined adjunctive minocycline (200 mg/day, in addition to treatment as usual) for major depressive disorder...
June 1, 2017: Australian and New Zealand Journal of Psychiatry
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