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McKenzie Method

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https://www.readbyqxmd.com/read/28777935/de-novo-mutations-in-ywhag-cause-early-onset-epilepsy
#1
Ilaria Guella, Marna B McKenzie, Daniel M Evans, Sarah E Buerki, Eric B Toyota, Margot I Van Allen, Mohnish Suri, Frances Elmslie, Marleen E H Simon, Koen L I van Gassen, Delphine Héron, Boris Keren, Caroline Nava, Mary B Connolly, Michelle Demos, Matthew J Farrer
Massively parallel sequencing has revealed many de novo mutations in the etiology of developmental and epileptic encephalopathies (EEs), highlighting their genetic heterogeneity. Additional candidate genes have been prioritized in silico by their co-expression in the brain. Here, we evaluate rare coding variability in 20 candidates nominated with the use of a reference gene set of 51 established EE-associated genes. Variants within the 20 candidate genes were extracted from exome-sequencing data of 42 subjects with EE and no previous genetic diagnosis...
August 3, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28767239/zein-nanoparticles-uptake-and-translocation-in-hydroponically-grown-sugarcane-plants
#2
Alisha Prasad, Carlos E Astete, Andreea Elena Bodoki, McKenzie Windham, Ede Bodoki, Cristina M Sabliov
The main objective of this study was to investigate the uptake and translocation of positively charged zein nanoparticles (ZNPs) in hydroponically grown sugarcane plants. Fluorescent ZNPs (spherical and measuring an average diameter 135±3 nm) were synthesized by emulsion-diffusion method from FITC-tagged zein. Fluorescent measurement following digestion of plant tissue indicated that sugarcane roots had a significant adhesion of ZNPs, 342.5±24.2 μg NPs/mg of dry matter, while sugarcane leaves contained a very limited amount, 12...
August 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28751646/an-integrative-computational-approach-to-evaluate-genetic-markers-for-bipolar-disorder
#3
Yong Xu, Jun Wang, Shuquan Rao, McKenzie Ritter, Lydia C Manor, Robert Backer, Hongbao Cao, Zaohuo Cheng, Sha Liu, Yansong Liu, Lin Tian, Kunlun Dong, Yin Yao Shugart, Guoqiang Wang, Fuquan Zhang
Studies to date have reported hundreds of genes connected to bipolar disorder (BP). However, many studies identifying candidate genes have lacked replication, and their results have, at times, been inconsistent with one another. This paper, therefore, offers a computational workflow that can curate and evaluate BP-related genetic data. Our method integrated large-scale literature data and gene expression data that were acquired from both postmortem human brain regions (BP case/control: 45/50) and peripheral blood mononuclear cells (BP case/control: 193/593)...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28718453/analysis-of-tcspc-data-a-comparative-evaluation-of-deterministic-and-probabilistic-approaches
#4
Darren Andrew Smith, Grant McKenzie, Anita C Jones, Trevor Smith
We review various methods for analysing time-resolved fluorescence data acquired using the time-correlated single photon counting (TCSPC) method in an attempt to evaluate their benefits and limitations. We have applied these methods to both experimental and simulated data. The relative merits of using deterministic approaches, such as the commonly used iterative reconvolution method, and probabilistic approaches, such as the smoothed exponential series method (SESM), the maximum entropy method (MEM) and recently proposed basis pursuit denoising (BPDN, compressed sensing) method are outlined...
July 18, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28701365/mckenzie-method-of-mechanical-diagnosis-and-therapy-was-slightly-more-effective-than-placebo-for-pain-but-not-for-disability-in-patients-with-chronic-non-specific-low-back-pain-a-randomised-placebo-controlled-trial-with-short-and-longer-term-follow-up
#5
Alessandra Narciso Garcia, Lucíola da Cunha Menezes Costa, Mark J Hancock, Fabrício Soares de Souza, Geórgia Vieira Freschi de Oliveira Gomes, Matheus Oliveira de Almeida, Leonardo Oliveira Pena Costa
BACKGROUND: The McKenzie Method of Mechanical Diagnosis and Therapy (MDT) is one of the exercise approaches recommended by low back pain (LBP) guidelines. We investigated the efficacy of MDT compared with placebo in patients with chronic LBP. METHODS: This was a prospectively registered, two-arm randomised placebo controlled trial, with a blinded assessor. A total of 148 patients seeking care for chronic LBP were randomly allocated to either MDT (n=74) or placebo (n=74)...
July 12, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28675977/the-reliability-of-measuring-acetabular-component-position-on-radiographs-using-everyday-diagnostic-imaging-software
#6
Jack Lahy, Jarrad Stevens, Dean McKenzie, Richard de Steiger
BACKGROUND: It is standard practice for total hip arthroplasty (THA) patients to have post-operative imaging, and one of the reasons is to assess the adequacy of acetabular component position. Correct positioning of the acetabular component is important for successful outcome in THA. Acetabular component position can be measured from either computed tomography (CT) or plain radiographs. While CT is the gold standard for accurately measuring acetabular component position, radiographs are routinely used for post-operative evaluation...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28646922/an-investigation-of-the-impact-of-using-different-methods-for-network-meta-analysis-a-protocol-for-an-empirical-evaluation
#7
Amalia Emily Karahalios, Georgia Salanti, Simon L Turner, G Peter Herbison, Ian R White, Areti Angeliki Veroniki, Adriani Nikolakopoulou, Joanne E Mckenzie
BACKGROUND: Network meta-analysis, a method to synthesise evidence from multiple treatments, has increased in popularity in the past decade. Two broad approaches are available to synthesise data across networks, namely, arm- and contrast-synthesis models, with a range of models that can be fitted within each. There has been recent debate about the validity of the arm-synthesis models, but to date, there has been limited empirical evaluation comparing results using the methods applied to a large number of networks...
June 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28645058/promoting-physical-activity-in-high-poverty-neighborhood-parks-a-cluster-randomized-controlled-trial
#8
Deborah A Cohen, Bing Han, Kathryn P Derose, Stephanie Williamson, Terry Marsh, Laura Raaen, Thomas L McKenzie
Although physical activity can help mitigate or prevent multiple chronic diseases, most people in the U.S., especially high-poverty minority groups, engage in insufficient levels of physical activity. To test ways to promote more physical activity in high-poverty area public parks we conducted a randomized controlled intervention trial. After completing baseline measures of park-based physical activity using systematic direct observation three times/day each month for six months and assessing preferences for park programming among 1445 residents living within 1 mile of study parks, we randomized 48 parks in high poverty neighborhoods in the City of Los Angeles, California during 2013-2014 to four study arms: 1) free physical activity classes over a 6-month period, 2) a frequent user program where participants could win prizes based upon the number of visits they made to the park, 3) both the programs, and 4) neither one (control condition)...
August 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28614809/monitoring-body-water-balance-in-pregnant-and-nursing-women-the-validity-of-urine-color
#9
Amy L McKenzie, Lawrence E Armstrong
BACKGROUND: Urine osmolality (UOSM) reflects the renal regulation of excess fluid or deficit fluid, and therefore, serves as a marker of hydration status. Little is known about monitoring hydration in pregnant and lactating women despite significant physiological challenges to body water balance during that time. Therefore, we designed a study to assess if urine color (UCOL), an inexpensive and practical method, was a valid means of assessing urine concentration. Twenty-four hour UCOL was significantly correlated with 24 h UOSM in all women: pregnant, lactating, and control (r = 0...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28599897/to-the-point-medical-education-technology-and-the-millennial-learner
#10
REVIEW
Laura Hopkins, Brittany S Hampton, Jodi F Abbott, Samantha D Buery-Joyner, LaTasha B Craig, John L Dalrymple, David A Forstein, Scott C Graziano, Margaret L McKenzie, Archana Pradham, Abigail Wolf, Sarah M Page-Ramsey
This article, from the "To The Point" series that was prepared by the Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee, provides an overview of the characteristics of millennials and describes how medical educators can customize and reframe their curricula and teaching methods to maximize millennial learning. A literature search was performed to identify articles on generational learning. We summarize the importance of understanding the attitudes, ideas, and priorities of millennials to tailor educational methods to stimulate and enhance learning...
June 28, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28578592/adjunctive-minocycline-treatment-for-major-depressive-disorder-a-proof-of-concept-trial
#11
Olivia M Dean, Buranee Kanchanatawan, Melanie Ashton, Mohammadreza Mohebbi, Chee Hong Ng, Michael Maes, Lesley Berk, Atapol Sughondhabirom, Sookjaroen Tangwongchai, Ajeet B Singh, Helen McKenzie, Deidre J Smith, Gin S Malhi, Nathan Dowling, Michael Berk
OBJECTIVE: Conventional antidepressant treatments result in symptom remission in 30% of those treated for major depressive disorder, raising the need for effective adjunctive therapies. Inflammation has an established role in the pathophysiology of major depressive disorder, and minocycline has been shown to modify the immune-inflammatory processes and also reduce oxidative stress and promote neuronal growth. This double-blind, randomised, placebo-controlled trial examined adjunctive minocycline (200 mg/day, in addition to treatment as usual) for major depressive disorder...
June 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28561887/reconciling-patient-and-provider-priorities-for-improving-the-care-of-critically-ill-patients-a-consensus-method-and-qualitative-analysis-of-decision-making
#12
Emily McKenzie, Melissa L Potestio, Jamie M Boyd, Daniel J Niven, Rebecca Brundin-Mather, Sean M Bagshaw, Henry T Stelfox
BACKGROUND: Providers have traditionally established priorities for quality improvement; however, patients and their family members have recently become involved in priority setting. Little is known about how to reconcile priorities of different stakeholder groups into a single prioritized list that is actionable for organizations. OBJECTIVE: To describe the decision-making process for establishing consensus used by a diverse panel of stakeholders to reconcile two sets of quality improvement priorities (provider/decision maker priorities n=9; patient/family priorities n=19) into a single prioritized list...
May 31, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28559667/inter-rater-reliability-of-the-mckenzie-system-of-mechanical-diagnosis-and-therapy-in-the-examination-of-the-knee
#13
Sean Willis, Richard Rosedale, Ravi Rastogi, Shawn M Robbins
OBJECTIVE: The McKenzie System of Mechanical Diagnosis and Therapy (MDT) is a widely used method of classification and management of musculoskeletal problems. Although MDT has been investigated for its reliability and efficacy in the management of spinal pain, few studies have evaluated the system when applying it to musculoskeletal problems in the extremities, in particular the knee. The purpose of this study was to investigate the inter-rater reliability of MDT when classifying clinical vignettes describing patients with musculoskeletal knee pain...
May 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28551398/regional-variation-in-skeletal-muscle-and-adipose-tissue-fdg-uptake-using-pet-ct-and-their-relation-to-bmi
#14
Marcus D Goncalves, Judith Green-McKenzie, Abass Alavi, Drew A Torigian
RATIONALE AND OBJECTIVES: Skeletal muscle metabolism is a primary contributor to whole-body energy expenditure. Currently, methods to measure changes in skeletal muscle metabolism in vivo are limited. Our objectives were to characterize the regional variation in skeletal muscle and adipose tissue (AT) FDG uptake as a surrogate for glycolytic metabolism using (18)F-2-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in healthy men and to correlate these findings to body mass index (BMI)...
May 24, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28535818/rapid-evaporative-ionisation-mass-spectrometry-of-electrosurgical-vapours-for-the-identification-of-breast-pathology-towards-an-intelligent-knife-for-breast-cancer-surgery
#15
Edward R St John, Julia Balog, James S McKenzie, Merja Rossi, April Covington, Laura Muirhead, Zsolt Bodai, Francesca Rosini, Abigail V M Speller, Sami Shousha, Rathi Ramakrishnan, Ara Darzi, Zoltan Takats, Daniel R Leff
BACKGROUND: Re-operation for positive resection margins following breast-conserving surgery occurs frequently (average = 20-25%), is cost-inefficient, and leads to physical and psychological morbidity. Current margin assessment techniques are slow and labour intensive. Rapid evaporative ionisation mass spectrometry (REIMS) rapidly identifies dissected tissues by determination of tissue structural lipid profiles through on-line chemical analysis of electrosurgical aerosol toward real-time margin assessment...
May 23, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28530116/autism-and-attachment-difficulties-overlap-of-symptoms-implications-and-innovative-solutions
#16
Rebecca McKenzie, Rudi Dallos
This article explores overlap of symptoms between autism and attachment difficulties and suggests innovative solutions based on formulation. Currently, clinicians express difficulties in differentiating between these conditions contributing to misdiagnosis. Research into the prevalence of attachment difficulties among children with autism often fails to reflect detailed knowledge of attachment theory. Consequently, studies in this area employ questionable modifications to attachment measures and methods of analysis...
May 1, 2017: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/28507724/deep-learning-and-3d-desi-imaging-reveal-the-hidden-metabolic-heterogeneity-of-cancer
#17
Paolo Inglese, James S McKenzie, Anna Mroz, James Kinross, Kirill Veselkov, Elaine Holmes, Zoltan Takats, Jeremy K Nicholson, Robert C Glen
Visual inspection of tumour tissues does not reveal the complex metabolic changes that differentiate cancer and its sub-types from healthy tissues. Mass spectrometry imaging, which quantifies the underlying chemistry, represents a powerful tool for the molecular exploration of tumour tissues. A 3-dimensional topological description of the chemical properties of the tumour permits the formulation of hypotheses about the biological composition and interactions and the possible causes of its heterogeneous structure...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28496219/the-flipped-classroom-for-pre-clinical-dental-skills-teaching-a-reflective-commentary
#18
A J Crothers, J Bagg, R McKenzie
A Flipped Classroom method for teaching of adult practical pre-clinical dental skills was introduced to the BDS curriculum in Glasgow during the 2015/2016 academic session. This report provides a commentary of the first year of employing this method - from the identification of the need to optimise teaching resources, through the planning, implementation and development of the method, with an early indication of performance.
May 12, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28483654/validity-of-robot-based-assessments-of-upper-extremity-function
#19
Alison McKenzie, Lucy Dodakian, Jill See, Vu Le, Erin Burke Quinlan, Claire Bridgford, Daniel Head, Vy L Han, Steven C Cramer
OBJECTIVE: To examine the validity of 5 robot-based assessments of arm motor function post-stroke. DESIGN: Cross sectional. SETTING: Outpatient clinical research center. PARTICIPANTS: Volunteer sample of 40 participants, age >18 years, 3-6 months post-stroke, with arm motor deficits that had plateaued. INTERVENTION: None. MAIN OUTCOME MEASURES: Clinical standards included the Fugl-Meyer Arm Motor Scale (FMA), and 5 secondary motor outcomes: hand/wrist subsection of the FMA; Action Research Arm Test (ART); Box & Blocks test (B/B); hand subscale of Stroke Impact Scale-2 (SIS); and the Barthel Index (BI)...
May 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28446138/assessing-the-complexity-of-interventions-within-systematic-reviews-development-content-and-use-of-a-new-tool-icat_sr
#20
Simon Lewin, Maggie Hendry, Jackie Chandler, Andrew D Oxman, Susan Michie, Sasha Shepperd, Barnaby C Reeves, Peter Tugwell, Karin Hannes, Eva A Rehfuess, Vivien Welch, Joanne E Mckenzie, Belinda Burford, Jennifer Petkovic, Laurie M Anderson, Janet Harris, Jane Noyes
BACKGROUND: Health interventions fall along a spectrum from simple to more complex. There is wide interest in methods for reviewing 'complex interventions', but few transparent approaches for assessing intervention complexity in systematic reviews. Such assessments may assist review authors in, for example, systematically describing interventions and developing logic models. This paper describes the development and application of the intervention Complexity Assessment Tool for Systematic Reviews (iCAT_SR), a new tool to assess and categorise levels of intervention complexity in systematic reviews...
April 26, 2017: BMC Medical Research Methodology
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