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Marc Cuesta, Nicolas Cermakian, Diane B Boivin
In humans, shift work induces a desynchronization between the circadian system and the outside world, which contributes to shift work-associated medical disorders. Using a simulated night shift experiment, we previously showed that 3 d of bright light at night fully synchronize the central clock to the inverted sleep schedule, whereas the peripheral clocks located in peripheral blood mononuclear cells (PBMCs) took longer to reset. This underlines the need for testing the effects of synchronizers on both the central and peripheral clocks...
April 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Lauren Laberge, Melanie Pratt
BACKGROUND: Both immediate, type I reactions and delayed hypersensitivity, type IV reactions to systemic corticosteroid preparations have been reported. Type I reactions are rare, with delayed hypersensitivity reactions being slightly more common. CASES: A 33-year-old woman presented repeatedly to the emergency department with asthma attacks. She developed pruritus and hives approximately 30 minutes after the administration of parenteral corticosteroids. Her respiratory status deteriorated approximately 6 hours after she received the corticosteroids...
November 2012: Dermatitis
Somya Verma, Carol Vanryzin, Ninet Sinaii, Mimi S Kim, Lynnette K Nieman, Shayna Ravindran, Karim A Calis, Wiebke Arlt, Richard J Ross, Deborah P Merke
OBJECTIVE: Existing glucocorticoid treatment for congenital adrenal hyperplasia (CAH) is suboptimal and nonphysiological. We compared hormonal profiles during therapy with a new modified-release hydrocortisone (MR-HC), Chronocort, to conventional hydrocortisone (HC), Cortef, in patients with CAH. DESIGN AND PATIENTS: We conducted a Phase 2, open-label, crossover pharmacokinetic and pharmacodynamic study in 14 patients (out of whom seven were male subjects, age ranging from 17 to 55) with classic 21-hydroxylase deficiency...
April 2010: Clinical Endocrinology
H J Lee, J Y Yoo, Y G Kim, S B Han, K R Lee
OBJECTIVE: A bioequivalence study ofprednisolone as Nisolone (test) tablets versus Delta-Cortef (reference) tablets was conducted. PATIENTS AND METHODS: Eighteen healthy male Korean volunteers received both 20 mg formulations of prednisolone in this 2 x 2 crossover study with a 1-week washout period between the doses. Plasma concentrations of prednisolone were monitored over a period of 12 hours after the administration using high-performance liquid chromatography...
September 2004: International Journal of Clinical Pharmacology and Therapeutics
Motoyuki Ishiguro, Shunsuke Mikasa, Michihiro Otani
REBIN GT SC (glyphosate isopropylamine and butafenacil, hereinafter referred to as "REBIN") is a nonselective herbicide which was developed by Syngenta Japan K. K. and was registered in July 2001 as a herbicide. We report the first case of acute poisoning by REBIN. In this case (Age 67, male), high fever and general fatigue developed immediately after REBIN inhalation. Furthermore, urine sugar, urine protein, high LDH and high GPT were observed. But the patient showed a tendency of recovery after the lapse of 48 hours by the intravenous fluid replacement, hydrocortisone sodium succinate (Solu-Cortef), glycyrrhizin (Stronger Neo-Minophagen C) and glutathione (Tathion)...
January 2004: Chūdoku Kenkyū: Chūdoku Kenkyūkai Jun Kikanshi, the Japanese Journal of Toxicology
Two groups of children with salaam seizures were studied-16 treated with routine anticonvulsants (control group) and 20 who had hydrocortisone added to their routine medication (Cortef-plus group). Results in the two groups were similar.
February 1964: California Medicine
No abstract text is available yet for this article.
July 1958: Metabolism: Clinical and Experimental
No abstract text is available yet for this article.
June 14, 1957: Prensa Médica Argentina
No abstract text is available yet for this article.
September 1956: Journal of the International College of Surgeons
No abstract text is available yet for this article.
March 15, 1956: Journal of the American Veterinary Medical Association
No abstract text is available yet for this article.
April 1955: Archivos Médicos Panameños
Lynda Bernsteen, Clare R Gregory, Andrew E Kyles, Stephen M Griffey, John Patz
OBJECTIVES: To determine whether the microemulsified formulation of cyclosporine (MCsA; Neoral; Novartis A.G.), combined with azathioprine (Imuran; Glaxo Wellcome), and prednisolone (Delta-Cortef; Upjohn), would be effective in preventing acute renal allograft rejection in unrelated mongrel dogs. To document any toxic effects associated with this drug combination. STUDY DESIGN: rospective, pilot study. ANIMALS: Four healthy, adult, mongrel, canine renal allograft recipients...
May 2003: Veterinary Surgery: VS
D P Merke, D Cho, K A Calis, M F Keil, G P Chrousos
In July 1998, Cortef oral suspension (Pharmacia & Upjohn) was reformulated changing the suspending agent tragacanth to xanthan gum. We subsequently observed suboptimal control of hormone levels in a group of children with classic congenital adrenal hyperplasia, despite increasing doses of Cortef suspension and stringent instructions to parents regarding shaking of the bottles of medication. Nineteen children receiving Cortef and fludrocortisone therapy were changed to hydrocortisone tablets and fludrocortisone, with a 10 percent reduction in hydrocortisone dose...
January 2001: Journal of Clinical Endocrinology and Metabolism
S Watanabe, M Kenmochi, H Kinoshita, I Kato
As an improved maintenance therapy for Bell's palsy, Stennert recently introduced large-dose steroid administration in the early stage of the disease with i.v. infusion of low-molecular dextran. The steroid administration aims at improving the microcirculation. This therapy achieved a 96% complete healing rate. However, because of side-effects such as hepatic and renal disorders or gastric ulcer, this therapy has not been widely used. In the present study, we investigated an improved treatment method based on Stennert's method...
1996: Acta Oto-laryngologica. Supplementum
C Geenen, I Tein, R M Ehrlich
BACKGROUND: Increased intracranial pressure with encephalopathy has rarely been reported in Addison's disease. METHOD: Case Study. RESULTS: A 16-year-old female who presented with cerebral edema of unknown etiology was eventually diagnosed as having Addison's disease. She had early morning headaches, fatiguability, diarrhea and deterioration in school performance. She was hyponatremic with a serum sodium of 128 mmol/L and hyperkalemic with a serum potassium of 5...
May 1996: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
C L Chen, J Goldberg, R R Gronwall
A radioimmunoassay was developed for prednisolone using IgG purified from rabbit antiserum. The assay was employed to determine the pharmacokinetics of prednisolone following intravenous administration of 450 mg of prednisolone sodium succinate (Solu Delta Cortef) to five adult Thoroughbred horses. The RIA had a sensitivity of 2 ng/ml and was relatively specific. It had cross-reactivity with 21-deoxycortisol (83.3%) cortisol (27.8%), 11-beta-hydroxyprogesterone (39.2%) and 17-hydroxyprogesterone (50%). However, it did not cross-react with naturally occurring steroids (cholesterol, testosterone, estradiol or progesterone) or synthetic steroids (betamethasone, methylprednisolone, prednisone or triamcinolone)...
1995: Chinese Journal of Physiology
T Yoshikawa, Y Iida, I Horiuchi, S Inaba, T Terai
This is a report of a male patient who had an anaphylaxia-like reaction to hydrocortisone sodium hemisuccinate (Solu-Cortef). A 32-year-old male with aspirin sensitivity was treated for moderate wheezing with 200 mg Solu-Cortef given intravenously. After this treatment, his condition deteriorated acutely and he was admitted to our hospital. Intradermal skin tests revealed positive immediate reactions to Solu-Cortef, Saxizon, Solu-Medrol and Predonine. Challenge tests with 100 mg Solu-Cortef and Saxizon injection showed 34% and 27% decrease, respectively in FEV1 15 min after injection...
August 1993: Nihon Kyōbu Shikkan Gakkai Zasshi
B M Dajani, N A Sliman, K S Shubair, Y S Hamzeh
Eleven patients with intrinsic asthma and aspirin sensitivity were challenged with intravenous hydrocortisone sodium succinate (Solu-Cortef; the Upjohn Co., Kalamazoo, Mich.). Three patients showed definite evidence of bronchospasm, which was easily reversed by subcutaneous administration of epinephrine. Evidence is presented which suggests that this reaction was not caused by other constituents of the preparation but rather was caused by Solu-Cortef alone. No atopy was demonstrated in the group as a whole, and the reaction observed was probably nonallergic in nature...
September 1981: Journal of Allergy and Clinical Immunology
G E Myers, F L Bloom
Cimetidine has recently proved useful in the prophylaxis of certain allergic and other histamine-mediated reactions. We have encountered a patient who had a serious cutaneous and respiratory reaction to Renografin-76 during cardiac catheterization. For the four days preceding his second catheterization, the patient was treated with prednisone, 30 mg daily, diphenhydramine, 25 mg orally, three times a day, intravenous diphenhydramine, 25 mg, three times a day, and Solu-Cortef, 500 mg, intravenously, every six hours...
1981: Catheterization and Cardiovascular Diagnosis
S E Mackinnon, A R Hudson, F Gentili, D G Kline, D Hunter
The possible neurotoxic effects of five commonly used steroid agents were examined. Using histologic studies and studies of the microneural circulation, it was found the steroids can indeed cause neurotoxicity. The injection site was critical in effecting injury. Only intrafascicular injection caused damage. The damage produced varied with the agent used. Dexamethasone (Decadron) caused minimal damage, while hydrocortisone (Solu-Cortef) and triamcinolone hexacetonide (Aristospan) caused widespread axonal and myelin degeneration...
March 1982: Plastic and Reconstructive Surgery
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