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Emmanuelle Gilot-Fromont, Mathieu Garel, Philippe Gibert, Sébastien Lambert, Pierre Menaut, Brigitte Bonetti, Yvette Game, Gaël Reynaud, Kévin Foulché
Understanding the dynamics of host-pathogen interaction is key to the management of epidemics. A pestivirus belonging to the border disease virus group 4 emerged around 2001 in Pyrenean chamois (Rupicapra pyrenaica) in Spain and France. The virus had significant demographic impact in some populations, but it was less harmful and more endemic in other places. The determinants of these local variations are still unclear. Here, we documented empirical evidence of self-clearance of the virus in a chamois population in France...
November 17, 2017: Journal of Wildlife Diseases
Jiawei Zhou, Alexandre Reynaud, Yeon Jin Kim, Kathy T Mullen, Robert F Hess
Temporarily depriving one eye of its input, in whole or in part, results in a transient shift in eye dominance in human adults, with the patched eye becoming stronger and the unpatched eye weaker. However, little is known about the role of colour contrast in these behavioural changes. Here, we first show that the changes in eye dominance and contrast sensitivity induced by monocular eye patching affect colour and achromatic contrast sensitivity equally. We next use dichoptic movies, customized and filtered to stimulate the two eyes differentially...
November 29, 2017: Proceedings. Biological Sciences
E Chadnova, A Reynaud, S Clavagnier, D H Baker, S Baillet, R F Hess
Interocular interaction in the visual system occurs under dichoptic conditions when contrast and luminance are imbalanced between the eyes. Human psychophysical investigations suggest that interocular interaction can be explained by a contrast normalization model. However, the neural processes that underlie such interactions are still unresolved. We set out to assess, for the first time, the proposed normalization model of interocular contrast interactions using magnetoencephalography (MEG) and to extend this model to incorporate interactions based on interocular luminance differences...
November 7, 2017: NeuroImage
Lydie Couturier, Khalil Mazouni, Fred Bernard, Charlotte Besson, Elodie Reynaud, François Schweisguth
In epithelia, mitotic cells round up and push against their neighbors to divide. Mitotic rounding results from increased assembly of F-actin and cortical recruitment of Myosin II, leading to increased cortical stability. Whether this process is developmentally regulated is not well known. Here, we examined the regulation of cortical stability in Sensory Organ precursor cells (SOPs) in the Drosophila pupal notum. SOPs differed in apical shape and actomyosin dynamics from their epidermal neighbors prior to division and appeared to have a more rigid cortex at mitosis...
November 3, 2017: Biology Open
Louis-François Tétreault, Naveen Eluru, Marianne Hatzopoulou, Patrick Morency, Celine Plante, Catherine Morency, Frederic Reynaud, Maryam Shekarrizfard, Yasmin Shamsunnahar, Ahmadreza Faghih Imani, Louis Drouin, Anne Pelletier, Sophie Goudreau, Francois Tessier, Lise Gauvin, Audrey Smargiassi
BACKGROUND: Since public transit infrastructure affects road traffic volumes and influences transportation mode choice, which in turn impacts health, it is important to estimate the alteration of the health burden linked with transit policies. OBJECTIVE: We quantified the variation in health benefits and burden between a business as usual (BAU) and a public transit (PT) scenarios in 2031 (with 8 and 19 new subway and train stations) for the greater Montreal region...
October 23, 2017: Environmental Research
Catherine Caris-Veyrat, Ada L Garcia, Eric Reynaud, Renata Lucas, Gamze Aydemir, Ralph Rühl
Lycopene is the red pigment in tomatoes and tomato products and is an important dietary carotenoid found in the human organism. Lycopene-isomers, oxidative lycopene metabolites and apo-lycopenoids are found in the food matrix. Lycopene intake derived from tomato consumption is associated with alteration of lipid metabolism and a lower incidence of cardiovascular diseases (CVD). Lycopene is mainly described as a potent antioxidant but novel studies are shifting towards its metabolites and their capacity to mediate nuclear receptor signalling...
October 20, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Athénaïs Boucly, Vincent Cottin, Hilario Nunes, Xavier Jaïs, Abdelatif Tazi, Grégoire Prévôt, Martine Reynaud-Gaubert, Claire Dromer, Catherine Viacroze, Delphine Horeau-Langlard, Christophe Pison, Emmanuel Bergot, Julie Traclet, Jason Weatherald, Gérald Simonneau, Dominique Valeyre, David Montani, Marc Humbert, Olivier Sitbon, Laurent Savale
Studies reporting the effects of modern strategies with pulmonary arterial hypertension (PAH)-targeted therapies in sarcoidosis-associated pulmonary hypertension (S-APH) are limited.Clinical and haemodynamic data from newly diagnosed patients with severe S-APH (mean pulmonary artery pressure (mPAP) >35 mmHg or mPAP 25-35 mmHg with cardiac index <2.5 L·min(-1)·m(-2)) were collected from the French Pulmonary Hypertension Registry between 2004 and 2015.Data from 126 patients with severe S-APH were analysed (mean±sd age 57...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Nicolas Crespo-Monteiro, Anthony Cazier, Francis Vocanson, Yaya Lefkir, Stéphanie Reynaud, Jean-Yves Michalon, Thomas Kämpfe, Nathalie Destouches, Yves Jourlin
The microstructuring of the distribution of silver nanoparticles (NPs) in mesoporous titania films loaded with silver salts, using two-beam interference lithography leading to 1 Dimension (1D) grating, induces variations in the photocatalytic efficiency. The influence of the structuration was tested on the degradation of methyl blue (MB) under ultraviolet (UV) and visible illumination, giving rise to a significant improvement of the photocatalytic efficiency. The periodic distribution of the NPs was characterized by transmission electron microscopy (TEM), high-angle annular dark field scanning transmission electron microscopy (HAADF-STEM) and scanning electron microscopy (SEM)...
October 17, 2017: Nanomaterials
Quitterie Reynaud, Muriel Rabilloud, Sylvain Roche, Stéphanie Poupon-Bourdy, Jean Iwaz, Raphaële Nove-Josserand, Emilie Blond, Martine Laville, Cathy Llerena, Sébastien Quetant, Philippe Reix, Sandrine Touzet, Isabelle Durieu
BACKGROUND: The prevalence of cystic fibrosis-related diabetes is increasing. This condition is potentially responsible for respiratory decline. METHODS: At inclusion, then yearly (over three years), 111 children and 117 adults with cystic fibrosis had oral glucose tolerance and insulin tests at one (G1) and 2h (G2). KmL analysis identified homogeneous G1 and G2 glucose trajectories. A linear mixed model quantified the relationships between trajectories and FEV1 changes...
October 13, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Arnaud Reynaud, Denis Lanzanova, Camino Liquete, Bruna Grizzetti
A contingent valuation approach is used to estimate how households value different multipurpose infrastructures (conventional or green) for managing flood risk and water pollution. As a case study we consider the Gorla Maggiore water park located in the Lombardy Region, in Northern Italy. The park is a neo-ecosystem including an infrastructure to treat waste water and store excess rain water, built in 2011 on the shore of the Olona River in an area previously used for poplar plantation. This park is the first one of this type built in Italy...
October 2017: Ecosystem Services
Catherine Martelli, Amélie Petillion, Marine Brunet-Lecomte, Rubén Miranda Marcos, Sandra Chanraud, Ammar Amirouche, Alexia Letierce, Nikoleta Kostogianni, Hervé Lemaitre, Henri-Jean Aubin, Lisa Blecha, Michel Reynaud, Jean-Luc Martinot, Amine Benyamina
BACKGROUND: Chronic alcoholism and its related cognitive impairments are associated with increased social, relational, and professional deficits which have a variable overall impact on social integration. These impairments are known to have varying severities and have rarely been studied among healthy alcohol-dependent subjects with preserved psychosocial functioning. Thus, the objective of this study is to describe neuropsychological performance in this particular population. METHOD: Twenty-nine socially adjusted alcohol-dependent men, hospitalized for a first or second withdrawal and abstinent for 3 weeks minimum, were compared to 29 healthy non-alcoholic controls...
2017: Frontiers in Psychiatry
Quitterie Reynaud, Damien Dupont, Raphaële Nove-Josserand, Stephane Durupt, Florence Persat, Florence Ader, Dominique Grenet, Isabelle Durieu
A 35-year-old woman with severe cystic fibrosis was admitted for sudden loss of strength in both legs, revealing a myelitis. The medullar lesion biopsy revealed phaeohyphomycosis caused by Cladophialophora species. Myelitis caused by Cladophialophora bantiana is a rare disease associated with high mortality. This article is protected by copyright. All rights reserved.
October 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
John A Bowden, Alan Heckert, Candice Z Ulmer, Christina M Jones, Jeremy P Koelmel, Laila Abdullah, Linda Ahonen, Yazen Alnouti, Aaron Armando, John M Asara, Takeshi Bamba, John R Barr, Jonas Bergquist, Christoph H Borchers, Joost Brandsma, Susanne B Breitkopf, Tomas Cajka, Amaury Cazenave-Gassiot, Antonio Checa, Michelle A Cinel, Romain A Colas, Serge Cremers, Edward A Dennis, James E Evans, Alexander Fauland, Oliver Fiehn, Michael S Gardner, Timothy J Garrett, Katherine H Gotlinger, Jun Han, Yingying Huang, Aveline Huipeng Neo, Tuulia Hyotylainen, Yoshihiro Izumi, Hongfeng Jiang, Houli Jiang, Jiang Jiang, Maureen Kachman, Reiko Kiyonami, Kristaps Klavins, Christian Klose, Harald C Kofeler, Johan Kolmert, Therese Koal, Grielof Koster, Zsuzsanna Kuklenyik, Irwin J Kurland, Michael Leadley, Karen Lin, Krishna Rao Maddipati, Danielle McDougall, Peter J Meikle, Natalie A Mellett, Cian Monnin, M Arthur Moseley, Renu Nandakumar, Matej Oresic, Rainey E Patterson, David Peake, Jason S Pierce, Martin Post, Anthony D Postle, Rebecca Pugh, Yunping Qui, Oswald Quehenberger, Parsram Ramrup, Jon Rees, Barbara Rembiesa, Denis Reynaud, Mary R Roth, Susanne Sales, Kai Schuhmann, Michal Laniado Schwartzman, Charles N Serhan, Andrej Shevchenko, Stephen E Somerville, Lisa St John-Williams, Michal A Surma, Hiroaki Takeda, Rhishikesh Thakare, J Will Thompson, Federico Torta, Alexander Triebl, Martin Trotzmuller, S J Kumari Ubhayasekera, Dajana Vuckovic, Jacquelyn M Weir, Ruth Welti, Markus R Wenk, Craig E Wheelock, Libin Yao, Min Yuan, Xueqing Heather Zhao, Senlin Zhou
As the lipidomics field continues to advance, self-evaluation within the community is critical. Here, we performed an interlaboratory comparison exercise for lipidomics using Standard Reference Material (SRM) 1950 Metabolites in Frozen Human Plasma, a commercially available reference material. The interlaboratory study comprised 31 diverse laboratories, with each lab using a different lipidomics workflow. A total of 1527 unique lipids were measured across all laboratories, and consensus location estimates and associated uncertainties were determined for 339 of these lipids measured at the sum composition level by five or more participating laboratories...
October 6, 2017: Journal of Lipid Research
Daniel A Giles, Maria E Moreno-Fernandez, Traci E Stankiewicz, Simon Graspeuntner, Monica Cappelletti, David Wu, Rajib Mukherjee, Calvin C Chan, Matthew J Lawson, Jared Klarquist, Annika Sünderhauf, Samir Softic, C Ronald Kahn, Kerstin Stemmer, Yoichiro Iwakura, Bruce J Aronow, Rebekah Karns, Kris A Steinbrecher, Christopher L Karp, Rachel Sheridan, Shiva K Shanmukhappa, Damien Reynaud, David B Haslam, Christian Sina, Jan Rupp, Simon P Hogan, Senad Divanovic
This corrects the article DOI: 10.1038/nm.4346.
October 6, 2017: Nature Medicine
Y Herry, O Reynaud, T Ferry, E Servien, P Neyret, S Lustig
The surgical treatment of septic non-union is challenging and carries a high failure rate. Bone defect management and fracture site stabilisation are key treatment objectives. We report the case of a 75-year-old woman who underwent intercalary endoprosthetic reconstruction of a large tibial defect due to septic non-union after two previous treatment failures. The two-stage procedure involved extensive excision of infected tissues and implantation of an antibiotic-loaded cement spacer followed by insertion of an intercalary endoprosthesis...
September 29, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
Frédérique Delannois, Camille Planty, Giulia Giordano, Eric Destexhe, Dinesh Stanislaus, Fernanda Tavares Da Silva, Jens-Ulrich Stegmann, Karen Thacker, Lucie Reynaud, Nathalie Garçon, Lawrence Segal
The potential reproductive and developmental toxicity of the synthetic oligodeoxynucleotide (ODN) CpG 7909, a component of GSK's AS15 immunostimulant, was examined in rat and rabbit studies following intermittent intramuscular injections. Previous studies using subcutaneous and intraperitoneal injections in mice, rats and rabbits revealed that CpG ODNs induced developmental effects. To analyze the safety signal, GSK conducted additional animal studies using the intended clinical route of administration. CpG 7909 injections were administered intramuscularly to rats or rabbits 28 and 14days before pairing, on 4 or 5 occasions during gestation, and on lactation day 7...
September 23, 2017: Reproductive Toxicology
Julien Gigault, Hind El Hadri, Stéphanie Reynaud, Elise Deniau, Bruno Grassl
In the last 10 years, asymmetrical flow field flow fractionation (AF4) has been one of the most promising approaches to characterize colloidal particles. Nevertheless, despite its potentialities, it is still considered a complex technique to set up, and the theory is difficult to apply for the characterization of complex samples containing submicron particles and nanoparticles. In the present work, we developed and propose a simple analytical strategy to rapidly determine the presence of several submicron populations in an unknown sample with one programmed AF4 method...
September 25, 2017: Analytical and Bioanalytical Chemistry
V Cottin, B Crestani, J Cadranel, J-F Cordier, S Marchand-Adam, G Prévot, B Wallaert, E Bergot, P Camus, J-C Dalphin, C Dromer, E Gomez, D Israel-Biet, S Jouneau, R Kessler, C-H Marquette, M Reynaud-Gaubert, B Aguilaniu, D Bonnet, P Carré, C Danel, J-B Faivre, G Ferretti, N Just, F Lebargy, B Philippe, P Terrioux, F Thivolet-Béjui, B Trumbic, D Valeyre
No abstract text is available yet for this article.
September 21, 2017: Revue des Maladies Respiratoires
E Novel Catin, S Durupt, L de Laforcade, M Lecoq, I Durieu, Q Reynaud
No abstract text is available yet for this article.
November 2017: Médecine et Maladies Infectieuses
V Cottin, B Crestani, J Cadranel, J-F Cordier, S Marchand-Adam, G Prévot, B Wallaert, E Bergot, P Camus, J-C Dalphin, C Dromer, E Gomez, D Israel-Biet, S Jouneau, R Kessler, C-H Marquette, M Reynaud-Gaubert, B Aguilaniu, D Bonnet, P Carré, C Danel, J-B Faivre, G Ferretti, N Just, F Lebargy, B Philippe, P Terrioux, F Thivolet-Béjui, B Trumbic, D Valeyre
No abstract text is available yet for this article.
October 2017: Revue des Maladies Respiratoires
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