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https://www.readbyqxmd.com/read/27897402/the-impact-of-ageing-physical-activity-and-pre-frailty-on-skeletal-muscle-phenotype-mitochondrial-content-and-intramyocellular-lipids-in-men
#1
Félix St-Jean-Pelletier, Charlotte H Pion, Jean-Philippe Leduc-Gaudet, Nicolas Sgarioto, Igor Zovilé, Sébastien Barbat-Artigas, Olivier Reynaud, Feras Alkaterji, François C Lemieux, Alexis Grenon, Pierrette Gaudreau, Russell T Hepple, Stéphanie Chevalier, Marc Belanger, José A Morais, Mylène Aubertin-Leheudre, Gilles Gouspillou
BACKGROUND: The exact impact of ageing on skeletal muscle phenotype and mitochondrial and lipid content remains controversial, probably because physical activity, which greatly influences muscle physiology, is rarely accounted for. The present study was therefore designed to investigate the effects of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, and mitochondrial and intramyocellular lipid content in men. METHODS: Recreationally active young adult (20-30 yo; YA); active (ACT) and sedentary (SED) middle-age (50-65 yo; MA-ACT and MA-SED); and older (65 + yo; 65 + ACT and 65 + SED) and pre-frail older (65 + PF) men were recruited...
September 2, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27887821/-sleep-disorders-in-internet-addiction
#2
Aymeric Petit, Laurent Karila, Candice Estellat, Delphine Moisan, Michel Reynaud, Marie-Pia D'Ortho, Michel Lejoyeux, Fanny Levy
BACKGROUND: The relationship between sleep disorders and Internet addiction has been little work. Given the importance of these disorders, we felt it appropriate to make a synthesis of available data and to establish causality or accountability between Internet addiction and the onset of sleep disorders. METHODS: A literature review was then performed. We selected scientific articles in English and French, published between 1987 and 2016 by consulting the databases Medline, Embase, PsycINFO and Google Scholar...
November 22, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27865400/new-mycobacterium-tuberculosis-lam-sublineage-with-geographical-specificity-for-the-old-world-revealed-by-phylogenetical-and-bayesian-analyses
#3
Yann Reynaud, Nalin Rastogi
We recently showed that the Mycobacterium tuberculosis sublineage LAM9 could be subdivided as two distinct subpopulations - each reflecting its unique biogeographical structure and evolutionary history. We subsequently attempted to verify if this genetic structuration could be traced in an enlarged global sample. For this purpose, we analyzed global evolutionary relationships of LAM strains in a large dataset (n = 1923 isolates from 35 countries worldwide) with concomitant spoligotyping and MIRU-VNTR data, followed by a deeper analysis of LAM9 sublineage (n = 851 isolates)...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27863844/persistent-impairment-of-quality-of-life-in-patients-with-herpes-simplex-keratitis
#4
Clotilde Reynaud, Antoine Rousseau, Godefroy Kaswin, Mohamed M'garrech, Emmanuel Barreau, Marc Labetoulle
PURPOSE: To evaluate the quality of life (QoL) in patients with quiescent herpes simplex keratitis compared with control patients without ocular herpes. DESIGN: Prospective, case-control study. PARTICIPANTS: Thirty-three patients with a unilateral and relapsing herpes simplex keratitis (HSK group) that was quiescent during evaluation (no acute episode in the past 3 months) and 66 patients with no history of HSK (control group). Both groups were age and gender matched...
November 15, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27836952/prevalence-and-characteristics-of-tert-and-terc-mutations-in-suspected-genetic-pulmonary-fibrosis
#5
Raphael Borie, Laure Tabèze, Gabriel Thabut, Hilario Nunes, Vincent Cottin, Sylvain Marchand-Adam, Grégoire Prevot, Abdellatif Tazi, Jacques Cadranel, Herve Mal, Lidwine Wemeau-Stervinou, Anne Bergeron Lafaurie, Dominique Israel-Biet, Clement Picard, Martine Reynaud Gaubert, Stephane Jouneau, Jean-Marc Naccache, Julie Mankikian, Christelle Ménard, Jean-François Cordier, Dominique Valeyre, Marion Reocreux, Bernard Grandchamp, Patrick Revy, Caroline Kannengiesser, Bruno Crestani
Telomerase reverse transcriptase (TERT) or telomerase RNA (TERC) gene mutation is a major monogenic cause of pulmonary fibrosis. Sequencing of TERT/TERC genes is proposed to patients with familial pulmonary fibrosis. Little is known about the possible predictors of this mutation and its impact on prognosis.We retrospectively analysed all the genetic diagnoses made between 2007-2014 in patients with pulmonary fibrosis. We evaluated the prevalence of TERT/TERC disease-associated variant (DAV), factors associated with a DAV, and the impact of the DAV on survival...
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27832302/rapid-ion-exchange-matrix-removal-for-a-decrease-of-detection-limits-in-the-analysis-of-salt-rich-reservoir-waters-for-fluorobenzoic-acids-by-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#6
Paweł Kubica, Véronique Vacchina, Tomasz Wasilewski, Stéphanie Reynaud, Joanna Szpunar, Ryszard Lobinski
A matrix removal procedure with ion-exchange resin prior to analysis for 18 fluorinated benzoic acids (FBAs) tracers in saline (>25% salt) reservoir water was optimized. The elimination of >98% of salt and the simultaneous matrix sample cleanup allowed the direct analysis using the supernatant by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). This resulted in a gain in detection limits for most of the tracers in comparison with the reference method (direct analysis after minimum required dilution)...
November 10, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27805387/magnetic-structures-of-orthorhombic-li2m-so4-2-m-co-fe-and-lixfe-so4-2-x-1-1-5-phases
#7
Laura Lander, Marine Reynaud, Juan Rodríguez-Carvajal, Jean-Marie Tarascon, Gwenaëlle Rousse
We report herein on the magnetic properties and structures of orthorhombic Li2M(SO4)2 (M = Co, Fe) and their oxidized phases LixFe(SO4)2 (x = 1, 1.5), which were previously studied as potential cathode materials for Li-ion batteries. The particular structure of these orthorhombic compounds (space group Pbca) consists of a three-dimensional network of isolated MO6 octahedra enabling solely super-super-exchange interactions between transition metals. We studied the magnetic properties of these phases via temperature-dependent susceptibility measurements and applied neutron powder diffraction experiments to solve their magnetic structures...
November 2, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27782778/surrogate-data-methods-based-on-a-shuffling-of-the-trials-for-synchrony-detection-the-centering-issue
#8
Mélisande Albert, Yann Bouret, Magalie Fromont, Patricia Reynaud-Bouret
We investigate several distribution-free dependence detection procedures, all based on a shuffling of the trials, from a statistical point of view. The mathematical justification of such procedures lies in the bootstrap principle and its approximation properties. In particular, we show that such a shuffling has mainly to be done on centered quantities-that is, quantities with zero mean under independence-to construct correct p-values, meaning that the corresponding tests control their false positive (FP) rate...
November 2016: Neural Computation
https://www.readbyqxmd.com/read/27776417/redox-active-carbohydrate-coated-nanoparticles-self-assembly-of-a-cyclodextrin-polystyrene-glycopolymer-with-tetrazine-naphthalimide
#9
Andrew Gross, Raoudha Haddad, Christophe Travelet, Eric Reynaud, Pierre Audebert, Redouane Borsali, Serge Cosnier
The controlled self-assembly of precise and well-defined photochemically and electrochemically active carbohydrate-coated nanoparticles offers the exiting prospect of biocompatible catalysts for energy storage/conversion and biolabeling applications. Here an aqueous nanoparticle system has been developed with a versatile outer layer for host-guest molecule encapsulation via β-cyclodextrin inclusion complexes. A β-cyclodextrin modified polystyrene polymer was first obtained by copper nanopowder "click chemistry"...
October 25, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27751650/impact-of-afterload-increase-on-left-ventricular-myocardial-deformation-indices
#10
Patricia Reant, Alexandre Metras, Dominique Detaille, Annabel Reynaud, Philippe Diolez, Beatrice Jaspard-Vinassa, Raymond Roudaut, Alexandre Ouattara, Laurent Barandon, Pierre Dos Santos, Stephane Lafitte
BACKGROUND: Left ventricular (LV) afterload could be associated with reduced myocardial contractility. The aim of this study was to evaluate the relative impact of increased afterload on LV myocardial deformation indices in chronic aortic constriction, with regard to hypertrophy, myocardial fibrosis, and mitochondrial function, and to differentiate acute versus chronic afterload effect. METHODS: Young pigs underwent aortic banding (n = 11) or sham (n = 7) operations...
December 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27746754/commentary-effects-of-dividing-attention-on-memory-for-declarative-and-procedural-aspects-of-tool-use
#11
COMMENT
François Osiurak, Emanuelle Reynaud, Jordan Navarro, Mathieu Lesourd
No abstract text is available yet for this article.
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27742687/lysyl-oxidase-is-a-strong-determinant-of-tumor-cell-colonization-in-bone
#12
Caroline Reynaud, Laura Ferreras, Paola Di Mauro, Casina Kan, Martine Croset, Edith Bonnelye, Floriane Pez, Clémence Thomas, Géraldine Aimont, Antoine E Karnoub, Marie Brevet, Philippe Clezardin
Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase whose primary function is to drive collagen crosslinking and extracellular matrix stiffness. LOX in colorectal cancer (CRC) synergizes with hypoxia-inducible factor-1 (HIF-1alpha to promote tumor progression. Here we investigated whether LOX/HIF1 endows CRC cells with full competence for aggressive colonization in bone. We show that a high LOX expression in primary tumors from CRC patients was associated with poor clinical outcome, irrespective of HIF-1...
October 14, 2016: Cancer Research
https://www.readbyqxmd.com/read/27737759/screening-for-cystic-fibrosis-related-diabetes-matching-pathophysiology-and-addressing-current-challenges
#13
Valérie Boudreau, Quitterie Reynaud, Catherine Lehoux Dubois, Adèle Coriati, Katherine Desjardins, Isabelle Durieu, Rémi Rabasa-Lhoret
Nearly 50% of adult patients with cystic fibrosis (CF) have diabetes. The occurrence of CF-related diabetes (CFRD) is preceded and is associated with deterioration of lung function and nutritional status. Microvascular complications can occur, but the main cause of death is respiratory failure rather than cardiovascular causes as in type 1 or type 2 diabetes. Because other methods such as glycated hemoglobin (A1C) levels are less sensitive in patients with CF, the recommended screening test is the oral glucose tolerance test (OGTT) with a 75 g glucose dose...
October 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27725340/free-floating-epithelial-micro-tissue-arrays-a-low-cost-and-versatile-technique
#14
P Flood, L Alvarez, E G Reynaud
Three-dimensional (3D) tissue models are invaluable tools that can closely reflect the in vivo physiological environment. However, they are usually difficult to develop, have a low throughput and are often costly; limiting their utility to most laboratories. The recent availability of inexpensive additive manufacturing printers and open source 3D design software offers us the possibility to easily create affordable 3D cell culture platforms. To demonstrate this, we established a simple, inexpensive and robust method for producing arrays of free-floating epithelial micro-tissues...
October 11, 2016: Biofabrication
https://www.readbyqxmd.com/read/27699409/is-suppression-just-normal-dichoptic-masking-suprathreshold-considerations
#15
Alexandre Reynaud, Robert F Hess
Purpose: Amblyopic patients have a deficit in visual acuity and contrast sensitivity in their amblyopic eye as well as suppression of the amblyopic eye input under binocular viewing conditions. In this study we wanted to assess the origin of the amblyopic suppression by studying the contrast perception of the amblyopic eye at suprathreshold levels under binocular and monocular viewing. Methods: Using a suprathreshold contrast matching task in which the reference and target stimuli were presented to different eyes either simultaneously or successively, we measured interocular contrast matching in 10 controls and 11 amblyopes (mean age 35 ± 15; 5 strabismics; 3 anisometropes; 3 mixed)...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27698074/successful-ivf-pregnancy-despite-inadequate-ovarian-steroidogenesis-due-to-congenital-lipoid-adrenal-hyperplasia-clah-a-case-report
#16
Frédérique Albarel, Jeanne Perrin, Margaux Jegaden, Florence Roucher-Boulez, Rachel Reynaud, Thierry Brue, Blandine Courbiere
Steroidogenic acute regulatory protein (StAR) mutations are the most frequent aetiologies of congenital lipoid adrenal hyperplasia (CLAH). Phenotypes may vary, and puberty may be absent in affected individuals. To date, only two pregnancies have been described in 46,XX CLAH patients with StAR mutations; these patients exhibited ovarian steroidogenesis along with spontaneous puberty and menarche and normal menses. The patient described here presented with CLAH caused by the homozygous (unreported, 1 bp) deletion c...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27691052/mtor-inhibitors-for-the-treatment-of-severe-congenital-hyperinsulinism-perspectives-on-limited-therapeutic-success
#17
Marie Szymanowski, Maria Salomon Estebanez, Raja Padidela, Bing Han, Karolina Mosinska, Adam Stevens, Lena Damaj, Florence Pihan-Le Bars, Emilie Lascouts, Rachel Reynaud, Catherine Ferreira, Claire Bansept, Pascale de Lonlay, Cécile Saint-Martin, Mark J Dunne, Indraneel Banerjee, Jean-Baptiste Arnoux
CONTEXT: Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycemia in neonates and infants. In medically unresponsive CHI, subtotal pancreatectomy is performed to achieve euglycaemia with consequent diabetes in later life. Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor has been reported to obviate the need for pancreatectomy, but experience is limited. OBJECTIVE: We have investigated the efficacy and adverse effect profile of mTOR inhibitors in the treatment of severe CHI...
October 3, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27667679/impact-of-micropollutants-on-the-life-history-traits-of-the-mosquito-aedes-aegypti-on-the-relevance-of-transgenerational-studies
#18
Sophie M Prud'homme, Arnaud Chaumot, Eva Cassar, Jean-Philippe David, Stéphane Reynaud
Hazard assessment of chemical contaminants often relies on short term or partial life-cycle ecotoxicological tests, while the impact of low dose throughout the entire life cycle of species across multiple generations has been neglected. This study aimed at identifying the individual and population-level consequences of chronic water contamination by environmental concentrations of three organic micropollutants, ibuprofen, bisphenol A and benzo[a]pyrene, on Aedes aegypti mosquito populations in experimental conditions...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27642151/-infant-food-diversification-assessment-of-practices-in-relation-to-french-recommendations-in-pediatricians-and-pediatric-residents-in-southern-france
#19
T Banti, A Carsin, B Chabrol, R Reynaud, A Fabre
: Infant food diversification has undergone a rapid succession of good practice recommendations in France, but there has been no assessment of pediatrician practices on food diversification. OBJECTIVE: To assess the practices of pediatricians in relation to current recommendations of the French Society of Pediatrics on infant food diversification. METHODS: This was an observational study conducted from 1 November 2014 to 31 March 2015. The study population consisted of 97 pediatricians in the Var department and 84 pediatric residents assigned to the University of Aix-Marseille in France...
October 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27627424/reply-to-comment-on-lifshitz-matsubara-sum-formula-for-the-casimir-pressure-between-magnetic-metallic-mirrors-%C3%A2
#20
R Guérout, A Lambrecht, K A Milton, S Reynaud
We reply to the "Comment on 'Lifshitz-Matsubara sum formula for the Casimir pressure between magnetic metallic mirrors.' " We believe the comment misrepresents our papers, and fails to provide a plausible resolution to the conflict between theory and experiment.
August 2016: Physical Review. E
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