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https://www.readbyqxmd.com/read/28231571/luminex-liquichip-system-for-the-evaluation-of-cytokine-levels-in-patients-with-contact-dermatitis-to-potassium-dichromate
#1
Lehavit Akerman, Tirza Klein, Moshe Israeli, Abigail Fraser, Eti Sagy, Igor Snast, Daniel Mimouni, Michael David, Akiva Trattner
BACKGROUND: Allergic contact dermatitis (ACD) is associated with increased production of cytokines. The patch test is the "gold-standard" diagnostic method, but it poses a risk of false results. OBJECTIVE: To evaluate a novel laboratory technique, the Luminex LiquiChip, which simultaneously measures blood levels of multiple cytokines, as a diagnostic tool in patients with chrome-induced ACD. METHODS: The study group included 20 patients with ACD and relevant patch test results for potassium dichromate and 19 patients with ACD for nickel or fragrance as control...
February 24, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28231564/mating-of-2-laboratory-saccharomyces-cerevisiae-strains-resulted-in-enhanced-production-of-2-phenylethanol-by-biotransformation-of-l-phenylalanine
#2
Jolanta Mierzejewska, Aleksandra Tymoszewska, Karolina Chreptowicz, Kamil Krol
2-Phenylethanol (2-PE) is an aromatic alcohol with a rosy scent which is widely used in the food, fragrance, and cosmetic industries. Promising sources of natural 2-PE are microorganisms, especially yeasts, which can produce 2-PE by biosynthesis and biotransformation. Thus, the first challenging goal in the development of biotechnological production of 2-PE is searching for highly productive yeast strains. In the present work, 5 laboratory Saccharomyces cerevisiae strains were tested for the production of 2-PE...
February 24, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28231056/temporal-and-regional-variability-in-the-request-of-vitamin-d-from-general-practitioners-in-spain
#3
Maria Salinas, Maite López-Garrigós, Emilio Flores, Carlos Leiva-Salinas
BACKGROUND: Our main goal is to study the inter-practice regional variability and the temporal evolution in the request of 25-hydroxyvitamin D (25[OH]D) by general practitioners (GPs) in Spain. METHODS: Clinical laboratories in different autonomic communities (AACCs) were invited to report the number of 25(OH)D test requested by GPs during 2012 and 2014. The number of 25(OH)D requested per 1000 inhabitants and the index of variability were calculated, and compared between regions and time periods...
February 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28230769/hypoallergenic-variant-of-the-major-egg-white-allergen-gal-d-1-produced-by-disruption-of-cysteine-bridges
#4
Pathum Dhanapala, Dulashi Withanage-Dona, Mimi L K Tang, Tim Doran, Cenk Suphioglu
Gal d 1 (ovomucoid) is the dominant allergen in the chicken egg white. Hypoallergenic variants of this allergen can be used in immunotherapy as an egg allergy treatment approach. We hypothesised that disruption of two of the nine cysteine-cysteine bridges by site-directed mutagenesis will allow the production of a hypoallergenic variant of the protein; Methods: Two cysteine residues at C192 and C210 in domain III of the protein were mutated to alanine using site-directed mutagenesis, to disrupt two separate cysteine-cysteine bridges...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28230634/platelet-dysfunction-in-critically-ill-patients
#5
Travis Hase, Sarah Sirajuddin, Patrick Maluso, Raksha Bangalore, Louis DePalma, Babak Sarani
Thrombelastography Platelet Mapping (TEG-PM) allows for measurement of maximal potential clot strength (MA) and strength from stimulation of arachidonic acid (MA-AA) and adenosine disphosphate (MA-ADP) receptors. This study was conducted to assess degree of platelet dysfunction in critically ill adult patients. A retrospective study of critically ill, adult, nontrauma patients in a medical/surgical ICU was conducted from August 2013 to September 2014. All patients who underwent TEG-PM were enrolled. Patients with intracerebral hemorrhage, following cardiac surgery, or without an APACHE II score were excluded...
February 21, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28230309/evaluation-of-positive-and-false-positive-results-in-syphilis-screening-of-blood-donors-in-rio-de-janeiro-brazil
#6
V S Sandes, S G C Silva, I J F Motta, L G C Velarde, S R de Castilho
OBJECTIVES: We propose to analyse the positive and false-positive results of treponemal and nontreponemal tests in blood donors from Brazil and to evaluate possible factors associated with the results of treponemal tests. BACKGROUND: Treponemal tests have been used widely for syphilis screening in blood banks. The introduction of these tests in donor screening has caused an impact and a loss of donors who need to be assessed. METHODS: This was a retrospective cross-sectional study of syphilis screening and confirmatory test results of blood donors that were obtained before and after adopting a chemiluminescent immunoassay (CLIA)...
February 23, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28230252/randomized-double-blind-placebo-controlled-phase-2-study-of-ganaxolone-as-add-on-therapy-in-adults-with-uncontrolled-partial-onset-seizures
#7
Michael R Sperling, Pavel Klein, Julia Tsai
OBJECTIVE: To evaluate the efficacy and safety of ganaxolone as adjunctive therapy in adults with uncontrolled partial-onset seizures despite taking up to three concomitant antiepileptic drugs (AEDs). METHODS: Adults aged 18-69 years and refractory to conventional AEDs were enrolled in a multicenter, double-blind, placebo-controlled trial. After an 8-week baseline period, patients were randomized 2:1 to ganaxolone 1,500 mg/day or placebo for a 10-week treatment period (2-week forced titration and 8-week maintenance) followed by either tapering or entry into an open-label extension study...
February 23, 2017: Epilepsia
https://www.readbyqxmd.com/read/28228092/variation-in-rates-of-spontaneous-male-production-within-the-nematode-species-pristionchus-pacificus-supports-an-adaptive-role-for-males-and-outcrossing
#8
Katy Morgan, Angela McGaughran, Christian Rödelsperger, Ralf J Sommer
BACKGROUND: The nematode species Pristionchus pacificus has an androdioecious mating system in which populations consist of self-fertilizing hermaphrodites and relatively few males. The prevalence of males in such a system is likely to depend on the relative pros and cons of outcrossing. While outcrossing generates novel allelic combinations and can therefore increase adaptive potential, it may also disrupt the potentially beneficial consequences of repeated generations of selfing. These include purging of deleterious alleles, inheritance of co-adapted allele complexes, improved hermaphrodite fitness and increased population growth...
February 23, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28227893/wearable-embroidered-muscle-activity-sensing-device-for-the-human-upper-leg
#9
R B Ribas Manero, A Shafti, B Michael, J Grewal, J Ll Ribas Fernandez, K Althoefer, M J Howard, R B Ribas Manero, A Shafti, B Michael, J Grewal, J Ll Ribas Fernandez, K Althoefer, M J Howard, K Althoefer, B Michael, A Shafti, J Ll Ribas Fernandez, J Grewal, M J Howard
Within the last decade, running has become one of the most popular physical activities in the world. Although the benefits of running are numerous, there is a risk of Running Related Injuries (RRIs) of the lower extremities. Electromyography (EMG) techniques have previously been used to study causes of RRIs, but the complexity of this technology limits its use to a laboratory setting. As running is primarily an outdoors activity, this lack of technology acts as a barrier to the study of RRIs in natural environments...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227680/a-mobile-platform-for-automated-screening-of-asthma-and-chronic-obstructive-pulmonary-disease
#10
Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher, Daniel B Chamberlain, Rahul Kodgule, Richard Ribon Fletcher, Daniel B Chamberlain, Richard Ribon Fletcher, Rahul Kodgule
Chronic Obstructive Pulmonary Disease (COPD) and asthma each represent a large proportion of the global disease burden; COPD is the third leading cause of death worldwide and asthma is one of the most prevalent chronic diseases, afflicting over 300 million people. Much of this burden is concentrated in the developing world, where patients lack access to physicians trained in the diagnosis of pulmonary disease. As a result, these patients experience high rates of underdiagnosis and misdiagnosis. To address this need, we present a mobile platform capable of screening for Asthma and COPD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227673/colorimetric-determinations-of-lithium-levels-in-drop-volumes-of-human-plasma-for-monitoring-patients-with-bipolar-mood-disorder
#11
M Qassem, M Hickey, P A Kyriacou, M Qassem, M Hickey, P A Kyriacou, M Qassem, M Hickey, P A Kyriacou
Lithium preparations are considered the most reliable form of mood stabilizing medication for patients with Bipolar disorder. Nevertheless, lithium is a toxic element and its therapeutic range is extremely narrow, with levels of 0.61.0 mEq considered normal, whereas levels above 1.5 mEq are toxic. Thus unfortunately, many patients reach toxic levels that lead to unnecessary complications. It is believed that personal monitoring of blood lithium levels would benefit patients taking lithium medication. Therefore, our aim is to develop a personal lithium blood level analyzer for patients with bipolar mood disorder, and we report here our initial results of a colorimetric-based method used to test drop-volumes of human plasma that had been spiked with lithium...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227670/diffuse-reflectance-spectroscopy-can-differentiate-high-grade-and-low-grade-prostatic-carcinoma
#12
Priya N Werahera, Edward A Jasion, E David Crawford, M Scott Lucia, Adrie van Bokhoven, Holly T Sullivan, Fernando J Kim, Paul D Maroni, J David Port, John W Daily, Francisco G La Rosa, Priya N Werahera, Edward A Jasion, E David Crawford, M Scott Lucia, Adrie van Bokhoven, Holly T Sullivan, Fernando J Kim, Paul D Maroni, J David Port, John W Daily, Francisco G La Rosa, John W Daily, Adrie Van Bokhoven, E David Crawford, J David Port, Priya N Werahera, M Scott Lucia, Holly T Sullivan, Paul D Maroni, Edward A Jasion, Francisco G La Rosa, Fernando J Kim
Prostate tumors are graded by the revised Gleason Score (GS) which is the sum of the two predominant Gleason grades present ranging from 6-10. GS 6 cancer exclusively with Gleason grade 3 is designated as low grade (LG) and correlates with better clinical prognosis for patients. GS >7 cancer with at least one of the Gleason grades 4 and 5 is designated as HG indicate worse prognosis for patients. Current transrectal ultrasound guided prostate biopsies often fail to correctly diagnose HG prostate cancer due to sampling errors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227218/effect-of-wearable-sensor-dynamics-on-physical-activity-estimates-a-comparison-between-sci-vs-healthy-individuals
#13
C Jayaraman, C K Mummidisetty, A Jayaraman, C Jayaraman, C K Mummidisetty, A Jayaraman, C K Mummidisetty, A Jayaraman, C Jayaraman
Accuracy of physical activity estimates predicted by activity monitoring technologies may be affected by device location, analysis algorithms, type of technology (i.e. wearable/stickable) and population demographics (disability) being studied. Consequently, the main purpose of this investigation was to study such sensor dynamics (i.e. effect of device location, type and population demographics on energy expenditure estimates) of two commercial activity monitors. It was hypothesized that device location, population studied (disability), choice of proprietary algorithm and type of technology used will significantly impact the accuracy of the predicted physical activity metrics...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227178/a-smartphone-application-suite-for-assessing-mobility
#14
Priyanka Madhushri, Armen A Dzhagaryan, Emil Jovanov, Aleksandar Milenkovic, Priyanka Madhushri, Armen A Dzhagaryan, Emil Jovanov, Aleksandar Milenkovic, Armen A Dzhagaryan, Priyanka Madhushri, Emil Jovanov, Aleksandar Milenkovic
Modern smartphones integrate a growing number of inertial and environmental sensors that can enable the development of new mobile health applications. In this paper we introduce a suite of smartphone applications for assessing mobility in elderly population. The suite currently includes applications that automate and quantify the following standardized medical tests for assessing mobility: Timed-Up-and-Go (TUG), 30 Seconds Chair Stand Test (30SCS), and a 4-stage Balance Test (4SBT). For each smartphone application we describe its functionality and a list of parameters extracted by processing signals from smartphone's inertial sensors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226919/an-online-recursive-autocalibration-of-triaxial-accelerometer
#15
Lin Ye, Steven W Su, Dong Lei, Hung T Nguyen, Lin Ye, Steven W Su, Dong Lei, Hung T Nguyen, Steven W Su, Hung T Nguyen, Lin Ye, Dong Lei
In this paper, we proposed a novel method for autocalibration of triaxial Micro-Electro-Mechanical systems (MEMS) accelerometer that does not require any sophisticated laboratory facilities. In particular, this method is an online calibration method which can be conveniently implemented with the accuracy of MEMS accelerometer being significantly improved. The procedure exploits the fact that the output vector of the accelerometer must match the local gravity in static state condition. To achieve online calibration, the model as well as the cost function are linearized at the beginning, and an online recursive method is then utilized to identify the unknown parameters and remove the bias caused by linearization...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226839/pendulum-test-measure-correlates-with-gait-parameters-in-children-with-cerebral-palsy
#16
M Lotfian, M M Mirbagheri, M R Kharazi, F Dadashi, R Nourian, A Irani, A Mirbagheri, M Lotfian, M M Mirbagheri, M R Kharazi, F Dadashi, R Nourian, A Irani, A Mirbagheri, M Lotfian, R Nourian, M M Mirbagheri, A Mirbagheri, A Irani, F Dadashi, M R Kharazi
Individuals with cerebral palsy (CP) usually suffer from different impairments including gait impairment and spasticity. Spastic hypertonia is a defining feature of spasticity and manifests as a mechanical abnormality. The objective of this study was to determine the relationship between spastic hypertonia and gait impairments in spastic children with CP, addressing an important controversial issue. Spastic hypertonia was quantified using the pendulum test. The gait impairments were evaluated using the motion capture system in a gait laboratory...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226335/repeated-quantitative-urine-toxicology-analysis-may-improve-chronic-pain-patient-compliance-with-opioid-therapy
#17
Nebojsa Nick Knezevic, Omar M Khan, Afsaneh Beiranvand, Kenneth D Candido
BACKGROUND: Even though serious efforts have been undertaken by different medical societies to reduce opioid use for treating chronic benign pain, many Americans continue to seek pain relief through opioid consumption. Assuring compliance of these patients may be a difficult aspect of proper management even with regular behavioral monitoring. OBJECTIVE: The purpose of this study was to accurately assess the compliance of chronic opioid-consuming patients in an outpatient setting and evaluate if utilizing repeated urine drug testing (UDT) could improve compliance...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28226272/automated-processing-extraction-and-detection-of-herpes-simplex-virus-types-1-and-2-a-comparative-evaluation-of-three-commercial-platforms-using-clinical-specimens
#18
Matthew J Binnicker, Mark J Espy, Brian Duresko, Cole Irish, Jay Mandrekar
BACKGROUND: Recently, automated platforms have been developed that can perform processing, extraction and testing for herpes simplex virus (HSV) nucleic acid on a single instrument. OBJECTIVES: In this study, we compared three commercially-available systems; Aptima(®)/Panther (Hologic, San Diego, CA), ARIES(®) (Luminex Corporation, Austin, TX), and cobas(®) 4800 (Roche Molecular Systems Inc, Pleasanton, CA) for the qualitative detection of HSV-1/2 in clinical samples...
February 14, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28225994/a-rare-case-of-ectopic-acth-syndrome-originating-from-malignant-renal-paraganglioma
#19
Esra Tutal, Demet Yılmazer, Taner Demirci, Evrim Cakır, Salih Sinan Gültekin, Bahadır Celep, Oya Topaloğlu, Erman Çakal
Ectopic adrenocorticotropic hormone (ACTH) syndrome is characterized by hypercortisolism due to the hypersecretion of a non-pituitary ACTH-secreting tumor leading to Cushing's syndrome. Only a few cases have been reported previously as causing ectopic ACTH related to paraganglioma. Herein, we present a case of Cushing's syndrome, in who was proved to be attributable to an ACTH-secreting renal malignant paraganglioma. A 40-year-old woman presented with a five-month history of newly diagnosed hypertension and diabetes, weakness, hyperpigmentation, oligomenorrhea, hirsutism, and acneiform lesions...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28225850/the-influence-of-morphological-awareness-on-reading-and-writing-a-systematic-review
#20
Ainoã Athaide Macedo Silva, Vanessa de Oliveira Martins-Reis
Purpose: this study aimed to perform a systematic review of national and international studies about the relationship between morphological awareness, reading/writing, reading comprehension, and spelling. Research strategies: a search for national and international literature was carried out using databases Medline (via PubMed) and Portal de Periódicos da Capes (Eric, PsycINFO, LILACS, SciELO) from August to September 2015. Selection criteria: the inclusion criteria were: studies that answered the guiding question and addressed the subject matter established by the descriptors and keywords...
February 16, 2017: CoDAS
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