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https://www.readbyqxmd.com/read/28749308/evaluation-of-the-effects-of-sternal-versus-lateral-recumbency-on-trends-of-selected-physiologic-parameters-during-isoflurane-anesthesia-in-zoo-housed-black-tailed-prairie-dogs-cynomys-ludovicianus
#1
David Eshar, Diane Mason, Nili Avni-Magen, Elizabeth Kaufman, Avital Paz, Hugues Beaufrère
Isoflurane gas anesthesia is often used for immobilization of prairie dogs in field studies, laboratory research, and veterinary clinical purposes. The goals of this prospective study were to evaluate the effects of sternal versus right lateral recumbency on trends of selected physiologic parameters during isoflurane anesthesia in black-tailed prairie dogs ( Cynomys ludovicianus ). Fourteen adult, zoo-housed black-tailed prairie dogs were tested during the study. Animals were anesthetized using isoflurane and randomly placed in either sternal or right lateral recumbency to evaluate changes in trends of physiologic parameters, measured selectively every 30 min throughout a 60-min anesthesia period...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28748882/superiority-of-peginterferon-%C3%AE-2a-and-ribavirin-combination-over-peginterferon-%C3%AE-2a-monotherapy-in-the-management-of-hemodialysis-patients-with-chronic-hepatitis-c-virus-infection
#2
Saeed M G Al-Ghamdi, Nasser Alaulaqi, Abdullah A Al-Amoudi, Amenah Alghamdi, Abbas Zagnoon, Bakr Ben Sadiq
Hepatitis C virus (HCV) is a common infection affecting 15% of hemodialysis population in Saudi Arabia resulting in delay in transplantation and long-term complications. The use of peginterferon resulted in sustained virologic response (SVR) in 40%-85% of patients, especially if combined with ribavirin. The treatment is hampered by the high dropout due to anemia and requirement of blood transfusion resulting from this therapy. Some studies have shown that the addition of increasing dose of erythropoiesis-stimulating agents (ESA) and reduced dose of ribavirin results in reduced dropout rate with high SVR...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748566/application-of-whole-exome-sequencing-to-direct-the-specific-functional-testing-and-diagnosis-of-rare-inherited-bleeding-disorders-in-patients-from-the-%C3%A3-resund-region-scandinavia
#3
Eva Leinøe, Eva Zetterberg, Savvas Kinalis, Olga Østrup, Peter Kampmann, Eva Norström, Nadine Andersson, Jenny Klintman, Klaus Qvortrup, Finn Cilius Nielsen, Maria Rossing
Rare inherited bleeding disorders (IBD) are a common cause of bleeding tendency. To ensure a correct diagnosis, specialized laboratory analyses are necessary. This study reports the results of an upfront diagnostic strategy using targeted whole exome sequencing. In total, 156 patients with a significant bleeding assessment tool score participated in the study, of which a third had thrombocytopenia. Eighty-seven genes specifically associated with genetic predisposition to bleeding were analysed by whole exome sequencing...
July 27, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28748194/recurrent-metatarsal-fractures-in-postmenopausal-woman-with-low-serum-alkaline-phosphatase-a-rare-diagnosis-not-to-miss
#4
Umair Iqbal, Hafsa Anwar, Ahmad Chaudhary, Madiha Alvi, Amy Freeth
Hypophosphatasia (HPP) is a rare inborn error of metabolism due to a loss-of-function mutation in the gene for tissue nonspecific isoenzyme of alkaline phosphatase (ALP) that results in low levels of ALP. The clinical presentation of HPP is variable and in adults can easily be misdiagnosed as other forms of osteomalacia. We present a case of a 53-year-old Caucasian female who was evaluated for recurrent metatarsal fractures. She reported her first metatarsal fracture at age 21, and since then had at least 8 more metatarsal fractures over her lifetime, most without injury other than weight bearing...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28747943/the-incidence-of-aspirin-resistance-in-heart-transplantation-recipients
#5
Tomasz Urbanowicz, Anna Komosa, Michał Michalak, Tatiana Mularek, Veronica Cassadei, Stefan Grajek, Marek Jemielity
INTRODUCTION: Coronary allograft vasculopathy can cause as many deaths as infections or rejection episodes within 3 years following heart transplantation. AIM: To compare the aspirin resistance rate in an allograft heart transplantation population and in a control group by laboratory tests including the Aspirin-Resistant Patients Identification Test (ASPItest). MATERIAL AND METHODS: A total of 24 heart recipients (20 men and 4 women) at a mean age of 48 ±13 years who underwent routine clinical follow-up were consecutively enrolled in group 1...
June 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28747798/microbial-planktonic-communities-in-the-red-sea-high-levels-of-spatial-and-temporal-variability-shaped-by-nutrient-availability-and-turbulence
#6
John K Pearman, Joanne Ellis, Xabier Irigoien, Y V B Sarma, Burton H Jones, Susana Carvalho
The semi-enclosed nature of the Red Sea (20.2°N-38.5°N) makes it a natural laboratory to study the influence of environmental gradients on microbial communities. This study investigates the composition and structure of microbial prokaryotes and eukaryotes using molecular methods, targeting ribosomal RNA genes across different regions and seasons. The interaction between spatial and temporal scales results in different scenarios of turbulence and nutrient conditions allowing for testing of ecological theory that categorizes the response of the plankton community to these variations...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747393/improving-validation-methods-for-molecular-diagnostics-application-of-bland-altman-deming-and-simple-linear-regression-analyses-in-assay-comparison-and-evaluation-for-next-generation-sequencing
#7
Maksym Misyura, Mahadeo A Sukhai, Vathany Kulasignam, Tong Zhang, Suzanne Kamel-Reid, Tracy L Stockley
AIMS: A standard approach in test evaluation is to compare results of the assay in validation to results from previously validated methods. For quantitative molecular diagnostic assays, comparison of test values is often performed using simple linear regression and the coefficient of determination (R(2)), using R(2) as the primary metric of assay agreement. However, the use of R(2) alone does not adequately quantify constant or proportional errors required for optimal test evaluation...
July 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28747375/evaluation-of-the-rapid-polymyxin-np-test-for-polymyxin-b-resistance-detection-using-enterobacter-cloacae-and-enterobacter-aerogenes-isolates
#8
Shelby Simar, Diane Sibley, Deborah Ashcraft, George Pankey
Background: Polymyxin resistance is an increasing problem worldwide. Currently, determining susceptibility to polymyxins is problematic and lengthy. Polymyxins diffuse poorly into agar, potentially giving inaccurate disk diffusion and Etest results. A rapid screening test (2 h) for detection of polymyxin-resistance in Enterobacteriaceae, developed by Nordmann and Poirel (Rapid Polymyxin NP Test, 2016), detects glucose metabolization in the presence of polymyxins E and B via pH-induced color change. Sensitivity/specificity were 99...
July 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28747232/development-of-an-accumulation-assay-and-evaluation-of-the-effects-of-efflux-pump-inhibitors-on-the-retention-of-chlorhexidine-digluconate-in-pseudomonas-aeruginosa-and-staphylococcus-aureus
#9
Molly Mombeshora, Stanley Mukanganyama
BACKGROUND: Chlorhexidine digluconate (CHG) is used as a disinfectant. The emergence of pathogens resistant to the biocide raises health concern. Information on specific efflux mechanisms utilised by bacteria to confer reduced susceptibility to the biocide, may be used to develop ways of preventing the efflux of the biocide from nosocomial pathogens resulting in higher disinfection activity. The aim of the study was to evaluate the role of ATP-binding cassette transporters on the transport of CHG in bacteria...
July 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28746261/rotavirus-infection-in-the-auckland-region-following-the-implementation-of-universal-infant-rotavirus-vaccination-impact-on-hospitalisations-and-laboratory-implications
#10
Gary N McAuliffe, Susan L Taylor, Dragana Drinković, Sally A Roberts, Elizabeth M Wilson, Emma J Best
BACKGROUND: In July 2014, New Zealand introduced universal infant vaccination with Rotateq (Merk & Co.) administered as three doses at 6 weeks, 3 and 5 months of age. We sought to assess the impact of rotavirus vaccination on gastroenteritis hospitalizations in the greater Auckland region and analyze changes in rotavirus testing in the period around vaccine introduction. METHODS: Hospitalizations, laboratory testing rates and methods were compared between the pre-vaccine period (2009-2013), post vaccine period (January-December 2015), and year of vaccine introduction (2014)...
July 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28745251/-using-thromboelastography-to-measure-coagulation-following-massive-blood-loss
#11
M C A Müller, G A E Ponjee
Thromboelastography is becoming increasingly important for diagnosing coagulation disorders in patients with massive blood loss. This whole-blood measurement provides information about the speed of clot formation, clot strength, and degree of fibrinolysis. The result can be used as a basis for making a faster and better choice of a suitable blood product for the patient with severe blood loss. This technique can be carried out simply and quickly as a rapid test ('point-of-care test') or in a central laboratory...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28745099/a-new-wireless-enabled-blood-glucose-monitoring-system-that-links-to-a-smart-mobile-device-accuracy-and-user-performance-evaluation
#12
Mark Christiansen, Carmine Greene, Scott Pardo, Mary Ellen Warchal-Windham, Bern Harrison, Robert Morin, Timothy S Bailey
BACKGROUND: These studies investigated the accuracy of the new Contour(®)Next ONE blood glucose monitoring system (BGMS) that is designed to sync with the Contour™ Diabetes app on a smartphone or tablet. METHODS: A laboratory study tested fingertip capillary blood samples from 100 subjects in duplicate using 3 test strip lots, based on ISO 15197:2013 Section 6.3 analytical accuracy standards. A clinical study assessed accuracy per ISO 15197:2013 Section 8 criteria...
May 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28744664/evaluation-of-the-carba-np-test-for-carbapenemase-detection-in-enterobacteriaceae-pseudomonas-spp-and-acinetobacter-spp-and-its-practical-use-in-the-routine-work-of-a-national-reference-laboratory-for-susceptibility-testing
#13
E Literacka, M Herda, A Baraniak, D Żabicka, W Hryniewicz, A Skoczyńska, M Gniadkowski
The aim of this study was to evaluate the Carba NP test (and CarbAcineto) for the detection of carbapenemases in Enterobacteriaceae, Pseudomonas spp. and Acinetobacter spp., and to assess its usefulness in the routine work of the National Reference Centre for Susceptibility Testing (NRCST) in Poland. The evaluation of the Carba NP/CarbAcineto tests was carried out on a group of 81 Enterobacteriaceae, Pseudomonas spp. and Acinetobacter spp. isolates producing KPC-, NDM-, VIM-, IMP- or OXA-48, -23, -24/40, -58-type carbapenemases, and on 26 carbapenemase-negative strains cultivated on a broad panel of microbiological media...
July 25, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28744099/pharmacokinetics-pharmacodynamics-and-tolerability-of-verinurad-a-selective-uric-acid-reabsorption-inhibitor-in-healthy-adult-male-subjects
#14
Zancong Shen, Michael Gillen, Jeffrey N Miner, Gail Bucci, David M Wilson, Jesse W Hall
PURPOSE: Verinurad (RDEA3170) is a selective uric acid reabsorption inhibitor in clinical development for the treatment of gout and asymptomatic hyperuricemia. The aim of this study was to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of verinurad in healthy adult males. SUBJECTS AND METHODS: This was a Phase I, randomized, double-blind, placebo-controlled, single and multiple ascending dose study. Panels of eight male subjects received a single oral dose of verinurad or placebo in either a fasted or fed state; panels of 10-12 male subjects received ascending doses of once-daily verinurad or placebo in a fasted state for 10 days...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28743758/ashp-national-survey-of-pharmacy-practice-in-hospital-settings-prescribing-and-transcribing-2016
#15
Craig A Pedersen, Philip J Schneider, Douglas J Scheckelhoff
PURPOSE: The results of the 2016 ASHP national survey of pharmacy practice in hospital settings are presented. METHODS: A stratified random sample of pharmacy directors at 1,315 general and children's medical-surgical hospitals in the United States were surveyed using a mixed-mode method offering a choice of completing a paper survey or an online survey. IMS Health supplied data on hospital characteristics; the survey sample was drawn from IMS's hospital database...
July 25, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28743683/cross-sectional-study-of-chronic-obstructive-pulmonary-disease-prevalence-among-smokers-ex-smokers-and-never-smokers-in-almaty-kazakhstan-study-protocol
#16
Almaz Sharman, Baurzhan Zhussupov, Dana Sharman, Assel Stambekova, Sattar Yeraliyev
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is significantly underdiagnosed in Kazakhstan, and there is no previously conducted study on COPD prevalence in the country. OBJECTIVE: The purpose of this study is to assess the prevalence of COPD among individuals aged 40 to 59 years based on results of spirometry before and after bronchodilator, presence of structural changes in the lungs (emphysema, inflammatory changes, and thickening of the walls of the large and small airways) detected by computer tomography, and the symptoms of COPD...
July 25, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28743682/estimating-heart-rate-energy-expenditure-and-physical-performance-with-a-wrist-photoplethysmographic-device-during-running
#17
Jakub Parak, Maria Uuskoski, Jan Machek, Ilkka Korhonen
BACKGROUND: Wearable sensors enable long-term monitoring of health and wellbeing indicators. An objective evaluation of sensors' accuracy is important, especially for their use in health care. OBJECTIVE: The aim of this study was to use a wrist-worn optical heart rate (OHR) device to estimate heart rate (HR), energy expenditure (EE), and maximal oxygen intake capacity (VO2Max) during running and to evaluate the accuracy of the estimated parameters (HR, EE, and VO2Max) against golden reference methods...
July 25, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28743645/extensively-drug-resistant-tuberculosis-in-morocco
#18
Wifak Ennassiri, Sanae Jaouhari, Wafa Cherki, Reda Charof, Abdelkarim Filali-Maltouf, Ouafae Lahlou
OBJECTIVES: Extensively drug-resistant tuberculosis (XDR-TB) has recently been identified as a major global health threat. The aim of the study was to evaluate the XDR-TB presence within TB isolates in Morocco, and its association with the demographic, clinical and epidemiological features. METHODS: A total of 524 patients from the National Tuberculosis Reference Laboratory, representative of all the geographic regions, were subject to first-line drug susceptibility testing (DST)...
July 22, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28743449/dengue-serotype-circulation-in-natural-populations-of-aedes-aegypti
#19
Taissa Pereira Dos Santos, Oswaldo Gonsalvez Cruz, Keli Antunes Barbosa da Silva, Márcia Gonçalves de Castro, Anielly Ferreira de Brito, Renato Cesar Maspero, Rosilene de Alcântra, Flávia Barreto Dos Santos, Nildimar A Honorio, Ricardo Lourenço-de-Oliveira
Ae. aegypti is the main vector of dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses. The transmission dynamics of these arboviruses, especially the arboviral circulation in the mosquito population during low and high transmission seasons in endemic areas are still poorly understood. We conducted an entomological survey to determine dengue infection rates in Ae. aegypti and Aedes albopictus. These collections were performed in 2012-2013 during a Rio de Janeiro epidemic, just before the introduction and spread of ZIKV and CHIKV in the city...
July 22, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28743387/polymerase-chain-reaction-based-detection-of-bacterial-16s-rrna-gene-in-the-cerebrospinal-fluid-in-the-diagnosis-of-bacterial-central-nervous-system-infection-in-the-course-of-external-cerebrospinal-fluid-drainage-comparison-with-standard-diagnostics-currently
#20
Piotr Dąbrowski, Jerzy Jurkiewicz, Zbigniew Czernicki, Waldemar Koszewski, Piotr Jasielski
BACKGROUND AND PURPOSE: External drainage of cerebrospinal fluid (CSF) is a commonly used neurosurgical procedure. Complications of the procedure comprise central nervous system (CNS) bacterial infections, the frequency of which is estimated at around 6-10%. Detection of these infections is ineffective in many cases. The aim of the study was to evaluate the usefulness of a polymerase chain reaction (PCR)-based detection of bacterial 16S rRNA gene (16S rDNA) in the CSF. MATERIAL AND METHODS: The study group consisted of 50 patients...
July 15, 2017: Neurologia i Neurochirurgia Polska
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