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https://www.readbyqxmd.com/read/28102949/simultaneous-pet-mr-imaging-with-a-radio-frequency-penetrable-pet-insert
#1
Alexander M Grant, Brian J Lee, Chen-Ming Chang, Craig S Levin
PURPOSE: A brain sized radio frequency (RF)-penetrable PET insert has been designed for simultaneous operation with MRI systems. This system takes advantage of electro-optical coupling and battery power to electrically float the PET insert relative to the MRI ground, permitting RF signals to be transmitted through small gaps between the modules that form the PET ring. This design facilitates the use of the built-in body coil for RF transmission and thus could be inserted into any existing MR site wishing to achieve simultaneous PET/MR imaging...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102900/metabolic-theory-predicts-animal-self-thinning
#2
Tomas Jonsson
1.The Metabolic Theory of Ecology (MTE) predicts observed patterns in ecology based on metabolic rates of individuals. The theory is influential but also criticized for a lack of firm empirical evidence confirming MTE's quantitative predictions of processes, e.g. outcome of competition, at population or community level. 2.Self-thinning is a well-known population level phenomenon among plants, but a much less studied phenomenon in animal populations and no consensus exists on what a universal thinning slope for animal populations might be, or if it exists...
January 19, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28102586/creatinine-in-urine-a-method-comparison
#3
Marc Luginbühl, Wolfgang Weinmann
Drug screening in urine is widely applied in forensic toxicology. Contrary to blood analysis, excessive or reduced fluid intake can substantially alter the concentration of substances in urine. As a standard to detect urinary dilution, creatinine concentrations are analyzed. A sample with a concentration below 20 mg/dL is generally defined as too diluted to provide a valid result in abstinence control samples. This work investigates the potential of three different methods for the determination of creatinine concentrations in urine samples: A ZIC-HILIC based LC-MS/MS method, a spectrophotometric method on an AU 480 chemistry system, and a portable, immunoassay based point-of-care testing device was compared by measuring 200 urine samples...
January 19, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28102352/reference-free-high-resolution-measurement-method-of-timing-jitter-spectra-of-optical-frequency-combs
#4
Dohyeon Kwon, Chan-Gi Jeon, Junho Shin, Myoung-Sun Heo, Sang Eon Park, Youjian Song, Jungwon Kim
Timing jitter is one of the most important properties of femtosecond mode-locked lasers and optical frequency combs. Accurate measurement of timing jitter power spectral density (PSD) is a critical prerequisite for optimizing overall noise performance and further advancing comb applications both in the time and frequency domains. Commonly used jitter measurement methods require a reference mode-locked laser with timing jitter similar to or lower than that of the laser-under-test, which is a demanding requirement for many laser laboratories, and/or have limited measurement resolution...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102036/combining-one-step-sanger-sequencing-with-phasing-probe-hybridization-for-hla-class-i-typing-yields-rapid-g-group-resolution-predicting-99-of-unique-full-length-protein-sequences
#5
Bin Tu, Carly Masaberg, Lihua Hou, Daniel Behm, Peter Brescia, Nuri Cha, Kanthi Kariyawasam, Jar How Lee, Thoa Nong, John Sells, Paul Tausch, Ruyan Yang, Jennifer Ng, Carolyn Katovich Hurley
BACKGROUND: Sanger-based DNA sequencing of exons 2+3 of HLA class I alleles from a heterozygote frequently results in two or more alternative genotypes. This study was undertaken to reduce the time and effort required to produce a single high resolution HLA genotype. MATERIALS AND METHODS: Samples were typed in parallel by Sanger sequencing and oligonucleotide probe hybridization. This workflow, together with optimization of analysis software, was tested and refined during the typing of over 42,000 volunteers for an unrelated hematopoietic progenitor cell donor registry...
February 2017: HLA
https://www.readbyqxmd.com/read/28101934/detection-of-neonatal-unit-clusters-of-candida-parapsilosis-fungaemia-by-microsatellite-genotyping-results-from-laboratory-based-sentinel-surveillance-south-africa-2009-2010
#6
Rindidzani E Magobo, Serisha D Naicker, Jeannette Wadula, Maphoshane Nchabeleng, Yacoob Coovadia, Anwar Hoosen, Shawn R Lockhart, Nelesh P Govender
Neonatal candidaemia is a common, deadly and costly hospital-associated disease. To determine the genetic diversity of Candida parapsilosis causing fungaemia in South African neonatal intensive care units (NICUs). From February 2009 through to August 2010, cases of candidaemia were reported through laboratory-based surveillance. C. parapsilosis isolates from neonatal cases were submitted for identification by internal transcribed spacer (ITS) region sequencing, antifungal susceptibility testing and microsatellite genotyping...
January 19, 2017: Mycoses
https://www.readbyqxmd.com/read/28101644/comparative-evaluation-of-phototrophic-microtiter-plate-cultivation-against-laboratory-scale-photobioreactors
#7
Holger Morschett, Danny Schiprowski, Jannis Rohde, Wolfgang Wiechert, Marco Oldiges
Extended cultivation times, rendering phototrophic bioprocess development time inefficient, resulted in the recent development of micro-photobioreactors enabling accelerated process development. However, especially for laboratory photobioreactors, only little is known concerning the influence of design on process performance. Thus, the aim of the present investigation was to evaluate the scalability of a microtiter plate-based parallelized micro-photobioreactor against a representative set of established laboratory photobioreactors...
January 18, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28100279/severe-community-acquired-adenovirus-pneumonia-treated-with-oral-ribavirin-a-case-report
#8
Byung Woo Yoon, Yong Geon Song, Seung Hyeun Lee
BACKGROUND: Adenovirus is a common pathogen of acute upper respiratory infection in children and is generally self-limiting. Severe adenovirus infections have been reported in immunocompromised hosts especially bone marrow transplantation recipients due to hematologic malignancy. Severe adenovirus pneumonia in immunocompetent hosts has rarely been reported and optimal treatment has not been established. We report a case of community-acquired severe adenovirus pneumonia which was successfully treated with early administration of oral ribavirin...
January 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28100271/evaluation-of-three-sample-preparation-methods-for-the-direct-identification-of-bacteria-in-positive-blood-cultures-by-maldi-tof
#9
Hannah Tanner, Jason T Evans, Savita Gossain, Abid Hussain
BACKGROUND: Patient mortality is significantly reduced by rapid identification of bacteria from sterile sites. MALDI-TOF can identify bacteria directly from positive blood cultures and multiple sample preparation methods are available. We evaluated three sample preparation methods and two MALDI-TOF score cut-off values. Positive blood culture bottles with organisms present in Gram stains were prospectively analysed by MALDI-TOF. Three lysis reagents (Saponin, SDS, and SepsiTyper lysis bufer) were applied to each positive culture followed by centrifugation, washing and protein extraction steps...
January 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28100191/diagnostic-dilemma-of-pulmonary-tuberculosis-among-adults-with-severe-mental-illness-in-beijing-china
#10
Li Wang, Zhiguo Zhang, Qiuli Yan, Jie Lu, Baoyin Gao, Yanlin Zhao, Yu Pang
BACKGROUND: Although the prevalence of tuberculosis has decreased significantly over the past decades, the certain populations with mental illness are at increased risk for tuberculosis infection and transmission. However, no studies have examined the performance of different laboratory examination methods among people with severe mental illness in China. METHODS: In this study, we firstly performed a retrospective study to evaluate the feasibility of three routine laboratory methods, including sputum microscopy, solid culture and GeneXpert, to diagnose tuberculosis patients with mental illness...
January 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28100131/influence-of-activated-sewage-sludge-amendment-on-pahs-removal-efficiency-from-a-naturally-contaminated-soil-application-of-the-landfarming-treatment
#11
Borislava Lukić, David Huguenot, Antonio Panico, Eric D van Hullebusch, Giovanni Esposito
The removal of polycyclic aromatic hydrocarbons (PAHs) from a naturally co-contaminated soil by PAHs and heavy metals with an initial concentration of 620 mg of total PAHs kg(-1) dry soil was investigated. The efficiency of landfarming in removing phenanthrene, pyrene, benzo(a)pyrene and the group of total 16 US EPA PAHs was evaluated. The process was biostimulated by adding centrifuged activated sewage sludge (SS) as an organic amendment. Experimental activities were conducted in four laboratory scale reactors filled with corn cobs as bulking agent to reach bulk density of 640 kg/m(3)...
January 18, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28100125/sulphur-dioxide-in-meat-products-3-years-control-results-of-an-accredited-italian-laboratory
#12
Marco Iammarino, Anna Rita Ientile, Aurelia Di Taranto
Sulphiting agents are well-known food preservatives. The European legislation does not allow their addition in fresh meat preparations. Therefore this type of food products has often been verified. To high sulphite levels in food is a health safety risk, due to toxic effects that these compounds may exercise on humans. In this study the control activity as performed by an Italian accredited laboratory from 2013 to 2015, relating to determination of sulphites in meat products, is described. Six hundred and sixty-nine meat product samples were analysed...
January 19, 2017: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/28099934/tolfenamic-acid-induced-alterations-in-genes-and-pathways-in-pancreatic-cancer-cells
#13
Umesh T Sankpal, Steve Goodison, Michelle Jones-Pauley, Myrna Hurtado, Fan Zhang, Riyaz Basha
Non-steroidal anti-inflammatory drugs (NSAIDs) are being tested extensively for their role in the treatment and prevention of several cancers. Typically NSAIDs exhibit anti-tumor activities via modulation of cyclooxygenase (COX)-dependent mechanisms, however, an anti-cancer NSAID tolfenamic acid (TA) is believed to work through COX-independent pathways. Results from our laboratory and others have demonstrated the anti-cancer activity of TA in various cancer models including pancreatic cancer. TA has been shown to modulate certain cellular processes including, apoptosis, reactive oxygen species and signaling...
January 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28098394/use-of-asian-samples-in-genetic-research-of-alcohol-use-disorders-genetic-variation-of-alcohol-metabolizing-enzymes-and-the-effects-of-acetaldehyde
#14
Sachio Matsushita, Susumu Higuchi
BACKGROUND AND OBJECTIVES: Epidemiological studies consistently find that Asian populations report lower rates of alcohol use disorders (AUD) compared with other racial groups. These differences result from a variety of biological, genetic, and environmental influences, some of which are related to the metabolism of alcohol. We will review several studies of these metabolic factors, including several alcohol clamping studies conducted in our laboratory, that provide further insight into the role of the alcohol metabolizing genes and drinking behavior among Japanese drinkers...
January 18, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28096618/evaluation-of-sperm-recovered-after-slaughter-from-cauda-epididymides-of-red-sokoto-bucks
#15
A H Abu, A I Kisani, T Ahemen
AIM: Viable spermatozoa could be recovered from the cauda epididymides for the purpose of preservation of genetic material of male animals with desirable traits and for use in reproductive biotechnology. The aim of this study was to determine the effect of storage time on testicular and epididymal biometry, sperm reserves and epididymal sperm characteristics of red Sokoto bucks post mortem. MATERIALS AND METHODS: Testes-epididymides were collected immediately after slaughter of mature red Sokoto bucks and transported in ice chest to the laboratory...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28095966/potential-underestimation-of-sleep-apnea-severity-by-at-home-kits-rescoring-in-laboratory-polysomnography-without-sleep-staging
#16
Matt T Bianchi, Balaji Goparaju
STUDY OBJECTIVES: Home sleep apnea testing (HSAT) is increasingly available for diagnosing obstructive sleep apnea (OSA). One key limitation of most HSAT involves the lack of sleep staging, such that the respiratory event index is calculated using the total recording time (TRT) rather than total sleep time (TST). METHODS: We performed a retrospective analysis of n = 838 diagnostic polysomnography (PSG) nights from our center; n = 444 with OSA (4% rule, apnea-hypopnea index (AHI) ≥ 5), and n = 394 with AHI < 5...
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28095905/imputing-hiv-treatment-start-dates-from-routine-laboratory-data-in-south-africa-a-validation-study
#17
Mhairi Maskew, Jacob Bor, Cheryl Hendrickson, William MacLeod, Till Bärnighausen, Deenan Pillay, Ian Sanne, Sergio Carmona, Wendy Stevens, Matthew P Fox
BACKGROUND: Poor clinical record keeping hinders health systems monitoring and patient care in many low resource settings. We develop and validate a novel method to impute dates of antiretroviral treatment (ART) initiation from routine laboratory data in South Africa's public sector HIV program. This method will enable monitoring of the national ART program using real-time laboratory data, avoiding the error potential of chart review. METHODS: We developed an algorithm to impute ART start dates based on the date of a patient's "ART workup", i...
January 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28095573/results-of-a-phase-2-randomized-vehicle-controlled-study-evaluating-the-efficacy-tolerability-and-safety-of-daily-or-twice-daily-sb204-for-the-treatment-of-acne-vulgaris
#18
Lawrence F Eichenfield, Linda Stein Gold, Walter K Nahm, Fran E Cook-Bolden, David M Pariser
OBJECTIVE: This randomized, double-blind, placebo-controlled, Phase 2 study compared efficacy, tolerability, and safety of SB204 once or twice daily to vehicle in the treatment of acne vulgaris. METHODS: Eligible subjects were to be between 12 and 40 years old, have facial acne vulgaris with 25 to 70 non-inflammatory lesions, 20 to 40 inflammatory lesions, no more than 2 nodules, and a baseline Investigator's Global Assessment (IGA) score of moderate or severe. The co-primary efficacy endpoints were the absolute change in inflammatory and non-inflammatory lesion counts and IGA success rate (baseline to week 12)...
December 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095109/test-retest-reliability-and-practice-effects-of-the-stability-evaluation-test
#19
Richelle M Williams, Matthew A Corvo, Kenneth C Lam, Travis A Williams, Lesley K Gilmer, Tamara C Valovich McLeod
CONTEXT: Postural control plays an essential role in concussion evaluation. The Stability Evaluation Test (SET) aims to objectively analyze postural control by measuring sway velocity on the NeuroCom's VSR portable force platform (Natus, San Carlos, CA). OBJECTIVE: To assess the test-retest reliability and practice effects of the SET protocol. DESIGN: Cohort. SETTING: Research Laboratory. PATIENTS OR OTHER PARTICIPANTS: Fifty healthy adults (males=20, females=30, age=25...
January 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28095108/the-relationship-between-2d-knee-valgus-angle-during-single-leg-squat-single-leg-land-and-drop-jump-screening-tests
#20
Allan Munro, Lee Herrington, Paul Comfort
CONTEXT: Anterior Cruciate Ligament (ACL) and Patellofemoral Joint (PFJ) injuries are a significant problem among female athletes. A number of screening tasks have been used in the literature to identify those at greatest risk of injury. To date, no study has examined the relationship in two-dimensional (2D) knee valgus between common screening tasks to determine whether individuals exhibit similar movement patterns across tasks. OBJECTIVE: to establish whether frontal plane projection angle (FPPA) during the single leg squat (SLS), single leg land (SLL) and drop jump (DJ) are related...
January 17, 2017: Journal of Sport Rehabilitation
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