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https://www.readbyqxmd.com/read/27911838/antagonists-of-growth-hormone-releasing-hormone-receptor-induce-apoptosis-specifically-in-retinoblastoma-cells
#1
Wai Kit Chu, Ka Sin Law, Sun On Chan, Jason Cheuk Sing Yam, Li Jia Chen, Hao Zhang, Herman S Cheung, Norman L Block, Andrew V Schally, Chi Pui Pang
Retinoblastoma (RB) is the most common intraocular cancer in children worldwide. Current treatments mainly involve combinations of chemotherapies, cryotherapies, and laser-based therapies. Severe or late-stage disease may require enucleation or lead to fatality. Recently, RB has been shown to arise from cone precursor cells, which have high MDM2 levels to suppress p53-mediated apoptosis. This finding leads to the hypothesis that restoring apoptosis mechanisms in RBs could specifically kill the cancer cells without affecting other retinal cells...
November 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27910717/dose-optimisation-for-assessment-of-periodontal-structures-in-cone-beam-ct-examinations
#2
Ayman Al-Okshi, Chrysoula Theodorakou, Christina Lindh
OBJECTIVE: To investigate the relationship between dose and image quality for a dedicated dental Cone Beam CT (CBCT) scanner using different scanning protocols and to set up an optimal imaging protocol for assessment of periodontal structures. METHODS: Radiation dose and image quality measurements were made using the 3D Accuitomo 170 dental CBCT scanner. The SedentexCT IQ phantom was used to investigate the relationship between contrast-to-noise ratio (CNR) and dose-area product (DAP)...
December 2, 2016: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/27910418/observation-of-hohlraum-wall-motion-with-spectrally-selective-x-ray-imaging-at-the-national-ignition-facility
#3
N Izumi, N B Meezan, L Divol, G N Hall, M A Barrios, O Jones, O L Landen, J J Kroll, S A Vonhof, A Nikroo, J Jaquez, C G Bailey, C M Hardy, R B Ehrlich, R P J Town, D K Bradley, D E Hinkel, J D Moody
The high fuel capsule compression required for indirect drive inertial confinement fusion requires careful control of the X-ray drive symmetry throughout the laser pulse. When the outer cone beams strike the hohlraum wall, the plasma ablated off the hohlraum wall expands into the hohlraum and can alter both the outer and inner cone beam propagations and hence the X-ray drive symmetry especially at the final stage of the drive pulse. To quantitatively understand the wall motion, we developed a new experimental technique which visualizes the expansion and stagnation of the hohlraum wall plasma...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910415/a-multi-cone-x-ray-imaging-bragg-crystal-spectrometer
#4
M Bitter, K W Hill, Lan Gao, P C Efthimion, L Delgado-Apariccio, S Lazerson, N Pablant
This article describes a new x-ray imaging Bragg crystal spectrometer, which-in combination with a streak camera or a gated strip detector-can be used for time-resolved measurements of x-ray line spectra at the National Ignition Facility and other high power laser facilities. The main advantage of this instrument is that it produces perfect images of a point source for each wavelength in a selectable spectral range and that the detector plane can be perpendicular to the crystal surface or inclined by an arbitrary angle with respect to the crystal surface...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27897156/quantitative-evaluation-of-the-mechanical-risks-caused-by-focal-cartilage-defects-in-the-knee
#5
Mikko S Venäläinen, Mika E Mononen, Jari Salo, Lasse P Räsänen, Jukka S Jurvelin, Juha Töyräs, Tuomas Virén, Rami K Korhonen
Focal cartilage lesions can proceed to severe osteoarthritis or remain unaltered even for years. A method to identify high risk defects would be of utmost importance to guide clinical decision making and to identify the patients that are at the highest risk for the onset and progression of osteoarthritis. Based on cone beam computed tomography arthrography, we present a novel computational model for evaluating changes in local mechanical responses around cartilage defects. Our model, based on data obtained from a human knee in vivo, demonstrated that the most substantial alterations around the defect, as compared to the intact tissue, were observed in minimum principal (compressive) strains and shear strains...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895995/photoreceptor-disc-shedding-in-the-living-human-eye
#6
Omer P Kocaoglu, Zhuolin Liu, Furu Zhang, Kazuhiro Kurokawa, Ravi S Jonnal, Donald T Miller
Cone photoreceptors undergo a daily cycle of renewal and shedding of membranous discs in their outer segments (OS), the portion responsible for light capture. These physiological processes are fundamental to maintaining photoreceptor health, and their dysfunction is associated with numerous retinal diseases. While both processes have been extensively studied in animal models and postmortem eyes, little is known about them in the living eye, in particular human. In this study, we report discovery of the optical signature associated with disc shedding using a method based on adaptive optics optical coherence tomography (AO-OCT) in conjunction with post-processing methods to track and monitor individual cone cells in 4D...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27894664/tomographic-osteometry-of-the-zygomatic-bone-applied-to-traumatology-of-facial-bones-preliminary-retrospective-study-of-zygomatic-summit-in-28-patients
#7
Barbara Lerhe, Sarah Alshehri, Denis Ferachon, Sébastien Dejean, Anne Sophie Salabert, Raphael Lopez
BACKGROUND: The available referential measures defining the zygomatic bone morphology are adequate enough for full determination of the zygoma positioning, especially for trauma surgery, but osteometric analysis of the zygoma positioning based on tomographic examinations could be useful in peroperative and postoperative imaging. In this study, we propose referential measures, taking into account the morphology and the symmetry of the zygoma. In addition, the reliability and reproducibility are considered...
October 28, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27893103/potential-of-small-molecule-mediated-reprogramming-of-rod-photoreceptors-to-treat-retinitis-pigmentosa
#8
Paul A Nakamura, Shibing Tang, Andy A Shimchuk, Sheng Ding, Thomas A Reh
Purpose: Mutations in rod photoreceptor genes can cause retinitis pigmentosa (RP). Rod gene expression is regulated by the nuclear hormone receptor, Nr2e3. Genetic deletion of Nr2e3 reprograms rods into cells that resemble cone photoreceptors, and might therefore prevent their death from some forms of RP. There are no identified ligands for Nr2e3; however, reverse agonists might mimic the genetic rescue effect and may be therapeutically useful for the treatment of RP. Methods: We screened for small molecule modulators of Nr2e3 using primary retinal cell cultures and characterized the most potent, which we have named photoregulin1 (PR1), in vitro and in vivo...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27887888/evaluating-outer-segment-length-as-a-surrogate-measure-of-peak-foveal-cone-density
#9
Melissa A Wilk, Brandon M Wilk, Christopher S Langlo, Robert F Cooper, Joseph Carroll
Adaptive optics (AO) imaging tools enable direct visualization of the cone photoreceptor mosaic, which facilitates quantitative measurements such as cone density. However, in many individuals, low image quality or excessive eye movements precludes making such measures. As foveal cone specialization is associated with both increased density and outer segment (OS) elongation, we sought to examine whether OS length could be used as a surrogate measure of foveal cone density. The retinas of 43 subjects (23 normal and 20 albinism; aged 6-67years) were examined...
December 1, 2016: Vision Research
https://www.readbyqxmd.com/read/27886322/the-electronic-structure-and-spin-states-of-2d-graphene-vx2-x-s-se-heterostructures
#10
Z I Popov, N S Mikhaleva, M A Visotin, A A Kuzubov, S Entani, H Naramoto, S Sakai, P B Sorokin, P V Avramov
The structural, magnetic and electronic properties of 2D VX2 (X = S, Se) monolayers and graphene/VX2 heterostructures were studied using a DFT+U approach. It was found that the stability of the 1T phases of VX2 monolayers is linked to strong electron correlation effects. The study of vertical junctions comprising of graphene and VX2 monolayers demonstrated that interlayer interactions lead to the formation of strong spin polarization of both graphene and VX2 fragments while preserving the linear dispersion of graphene-originated bands...
November 25, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27883057/the-warburg-effect-mediator-pyruvate-kinase-m2-expression-and-regulation-in-the-retina
#11
Raju V S Rajala, Ammaji Rajala, Christopher Kooker, Yuhong Wang, Robert E Anderson
The tumor form of pyruvate kinase M2 (PKM2) undergoes tyrosine phosphorylation and gives rise to the Warburg effect. The Warburg effect defines a pro-oncogenic metabolism switch such that cancer cells take up more glucose than normal tissue and favor incomplete oxidation of glucose, even in the presence of oxygen. Retinal photoreceptors are highly metabolic and their energy consumption is equivalent to that of a multiplying tumor cell. In the present study, we found that PKM2 is the predominant isoform in both rod- and cone-dominant retina, and that it undergoes a light-dependent tyrosine phosphorylation...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882899/an-ab-initio-investigation-of-bi2se3-topological-insulator-deposited-on-amorphous-sio2
#12
I S S de Oliveira, W L Scopel, R H Miwa
We use first-principles simulations to investigate the topological properties of Bi2Se3 thin films deposited on amorphous SiO2, Bi2Se3/a-SiO2, which is a promising substrate for topological insulator (TI) based device applications. The Bi2Se3 films are bonded to a-SiO2 mediated by van der Waals interactions. Upon interaction with the substrate, the Bi2Se3 topological surface and interface states remain present, however the degeneracy between the Dirac-like cones is broken. The energy separation between the two Dirac-like cones increases with the number of Bi2Se3 quintuple layers (QLs) deposited on the substrate...
November 24, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27880916/nrl-regulated-transcriptome-dynamics-of-developing-rod-photoreceptors
#13
Jung-Woong Kim, Hyun-Jin Yang, Matthew John Brooks, Lina Zelinger, Gökhan Karakülah, Norimoto Gotoh, Alexis Boleda, Linn Gieser, Felipe Giuste, Dustin Thad Whitaker, Ashley Walton, Rafael Villasmil, Jennifer Joanna Barb, Peter Jonathan Munson, Koray Dogan Kaya, Vijender Chaitankar, Tiziana Cogliati, Anand Swaroop
Gene regulatory networks (GRNs) guiding differentiation of cell types and cell assemblies in the nervous system are poorly understood because of inherent complexities and interdependence of signaling pathways. Here, we report transcriptome dynamics of differentiating rod photoreceptors in the mammalian retina. Given that the transcription factor NRL determines rod cell fate, we performed expression profiling of developing NRL-positive (rods) and NRL-negative (S-cone-like) mouse photoreceptors. We identified a large-scale, sharp transition in the transcriptome landscape between postnatal days 6 and 10 concordant with rod morphogenesis...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27878463/tracking-of-the-inferior-alveolar-nerve-its-implication-in-surgical-planning
#14
Jimoh O Agbaje, Elke Van de Casteele, Ahmed S Salem, Dickson Anumendem, Ivo Lambrichts, Constantinus Politis
OBJECTIVES: The objective of the study is to assess the correlation between the mandibular canal tracing done on cone beam CT (CBCT) data, with the size, shape, and position of the neurovascular bundle (NB) obtained by magnetic resonance imaging (MRI). MATERIAL AND METHODS: Six human cadaver mandibles were scanned with a CBCT Promax® scanner (Planmeca, Helsinki, Finland) and with an Ingenia® 3.0 T MR system (Philips, Amsterdam, The Netherlands). The NB was segmented from the MRI dataset, while the mandibular canal (MC) tracing was done on the CBCT images...
November 22, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27876714/-prospects-of-endoscopic-technology-for-diagnostics-of-inflammatory-periodontal-disease
#15
L Yu Orekhova, D M Neizberg, T V Demchenko, N A Artem'ev, E S Loboda
The aim of the study was to analyze research methods for periodontitis severity and elaborate the most effective diagnostic combination. Twenty patients with moderate periodontal disease were included in the study. In addition to conventional diagnostic methods depth of periodontal pockets (PP) was measured by means of endoscopic system and cone bean CT. Differences in PP depth estimated by probing and endoscopic evaluation was 1.2±0.4 mm proving endoscopic method to be useful and most precise tool for periodontal diagnostics...
2016: Stomatologii︠a︡
https://www.readbyqxmd.com/read/27867168/clinical-experience-of-dual-phase-cone-beam-computed-tomography-during-hepatic-arteriography-to-apply-3d-dsa
#16
Yoshinori Takao, Akihiko Kakimi, Yutaka Katayama, Shohei Sasaki, Toshiyo Norimasa, Shinichiro Izuta, Daisuke Himoto, Takao Ichida
We report on the methods and experiences of the dual-phase cone beam computed tomography during hepatic arteriography (CBCTHA) to apply the 3D-DSA. A total of 32 ml contrast medium (150 mgI/ml) was injected at the rate of 2.0 ml/s for 16 s. The early phase scan was initiated 10 s after the start of contrast media injection. The delayed phase scan was started 40 s after that (24 s after the end of CM injection). When using the dual phase CBCTHA, it was able to obtain the classical hepatocellular carcinoma (HCC) images same as computed tomography during hepatic arteriography (CTHA)...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27861878/sequence-and-localization-of-an-ultraviolet-sws1-opsin-in-the-retina-of-the-japanese-sardine-sardinops-melanostictus-teleostei-clupeiformes
#17
T Miyazaki, S L Kondrashev, S Kasagi, K Mizusawa, A Takahashi
A full-length complementary (c)DNA encoding ultraviolet (UV)-sensitive opsin (sws1) was isolated from the retina of the Japanese sardine Sardinops melanostictus. The sws1 phylogenetic tree showed a sister group relationship with the Cypriniformes, following the ray-finned fish phylogeny. By expressing reconstituted opsin in vitro, it was determined that the maximum absorbance spectrum (λmax ) of sws1 is around 382 nm, being intermediate in position between two subtypes of sws1 pigment that are UV sensitive (λmax  = 355-380 nm) and violet sensitive (λmax  = 388-455 nm), which have been reported to date...
November 16, 2016: Journal of Fish Biology
https://www.readbyqxmd.com/read/27857875/dual-endoscopic-endonasal-transsphenoidal-and-precaruncular-transorbital-approaches-for-clipping-of-the-cavernous-carotid-artery-a-cadaveric-simulation
#18
Jeremy Ciporen, Brandon Lucke-Wold, Aclan Dogan, Justin S Cetas, William E Cameron
Background Endoscopic skull base approaches are being used to address complicated neurovascular pathology. These approaches are safest when proximal vascular control of the cavernous carotid artery (CavCA) can be obtained. Methods We present a cadaver-based anatomic simulation study showing the feasibility of clip placement for the CavCA as it courses through the cavernous sinus. The arterial vessels were injected with red microfil (Flow Tech, Carver, Massachusetts) to enhance visibility. The endoscope was directed through a precaruncular transorbital approach and instrumentation was managed through an endonasal transsphenoidal approach...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27856902/perovskite-perovskite-tandem-photovoltaics-with-optimized-band-gaps
#19
Giles E Eperon, Tomas Leijtens, Kevin A Bush, Rohit Prasanna, Thomas Green, Jacob Tse-Wei Wang, David P McMeekin, George Volonakis, Rebecca L Milot, Richard May, Axel Palmstrom, Daniel J Slotcavage, Rebecca A Belisle, Jay B Patel, Elizabeth S Parrott, Rebecca J Sutton, Wen Ma, Farhad Moghadam, Bert Conings, Aslihan Babayigit, Hans-Gerd Boyen, Stacey Bent, Feliciano Giustino, Laura M Herz, Michael B Johnston, Michael D McGehee, Henry J Snaith
We demonstrate four- and two-terminal perovskite-perovskite tandem solar cells with ideally matched band gaps. We develop an infrared-absorbing 1.2-electron volt band-gap perovskite, FA0.75Cs0.25Sn0.5Pb0.5I3, that can deliver 14.8% efficiency. By combining this material with a wider-band gap FA0.83Cs0.17Pb(I0.5Br0.5)3 material, we achieve monolithic two-terminal tandem efficiencies of 17.0% with >1.65-volt open-circuit voltage. We also make mechanically stacked four-terminal tandem cells and obtain 20.3% efficiency...
November 18, 2016: Science
https://www.readbyqxmd.com/read/27856149/accuracy-of-three-dimensional-soft-tissue-prediction-for-le-fort-i-osteotomy-using-dolphin-3d-software-a-pilot-study
#20
C M Resnick, R R Dang, S J Glick, B L Padwa
Three-dimensional (3D) soft tissue prediction is replacing two-dimensional analysis in planning for orthognathic surgery. The accuracy of different computational models to predict soft tissue changes in 3D, however, is unclear. A retrospective pilot study was implemented to assess the accuracy of Dolphin 3D software in making these predictions. Seven patients who had a single-segment Le Fort I osteotomy and had preoperative (T0) and >6-month postoperative (T1) cone beam computed tomography (CBCT) scans and 3D photographs were included...
November 14, 2016: International Journal of Oral and Maxillofacial Surgery
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