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https://www.readbyqxmd.com/read/29778065/reliability-of-the-sub-components-of-the-instrumented-timed-up-and-go-test-in-ambulatory-children-with-traumatic-brain-injury-and-typically-developed-controls
#1
Mark A Newman, Mark A Hirsch, Richard D Peindl, Nahir A Habet, Tobias J Tsai, Michael S Runyon, Toan Huynh, Nigel Zheng
BACKGROUND: Studies have evaluated the test-re-test reliability of subcomponents of the timed up and-go test in adults by using body-worn inertial sensors. However, studies in children have not been reported in the literature. RESEARCH QUESTION: To evaluate the within-session reliability of subcomponents of a newly developed electronically augmented timed 'upand-go' test (EATUG) in ambulatory children with traumatic brain injury (TBI) and children with typical development (TD)...
May 16, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29776719/three-dimensional-changes-of-proximal-segments-in-facial-asymmetry-patients-after-bilateral-vertical-ramus-osteotomy
#2
J W Huh, S Y Kim, Y-B Lee, J H Park, H-D Jung, Y-S Jung
The intraoral vertical ramus osteotomy (IVRO) is a useful technique for mandibular setback surgery. However, there is a tendency for lateral flaring of the proximal segments on the non-deviation side after the correction of mandibular asymmetry with this technique. The purpose of this retrospective study was to evaluate the positional changes of the proximal segments after IVRO setback in skeletal class III patients with asymmetry, using preoperative and postoperative computed tomography scan data, and to apply the results in clinical practice...
May 15, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29775563/anolis-carolinensis-as-a-model-to-understand-molecular-and-cellular-basis-of-foveal-development
#3
Naif S Sannan, Xianghong Shan, Kevin Gregory-Evans, Kenro Kusumi, Cheryl Y Gregory-Evans
The fovea is an anatomical specialization of the central retina containing closely packed cone-photoreceptors providing an area of high acuity vision in humans and primates. Despite its key role in the clarity of vision, little is known about the molecular and cellular basis of foveal development, due to the absence of a foveal structure in commonly used laboratory animal models. Of the amniotes the retina in birds of prey and some reptiles do exhibit a typical foveal structure, but they have not been studied in the context of foveal development due to lack of availability of embryonic tissue, lack of captive breeding programs, and limited genomic information...
May 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29774779/image-guided-radiation-therapy-for-post-operative-gynaecologic-cancer-patient-set-up-verification-with-and-without-implanted-fiducial-markers
#4
Donna H Murrell, Andrew Warner, Quinn Benwell, Wendy Wells, Danielle Scott, Vikram Velker, George Hajdok, David P D'Souza
BACKGROUND: Intensity modulated radiotherapy (IMRT) is increasingly being used to treat gynaecological malignancies in the postoperative setting. The purpose of this study was to evaluate the use of image-guided radiotherapy (IGRT) using cone-beam computed tomography (CBCT) with fiducial markers for daily localization. MATERIAL AND METHODS: A single institution study was performed of consecutive cervical or endometrial cancer patients receiving adjuvant external beam radiotherapy (n = 15)...
May 18, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29773814/melanopsin-mediated-pupil-function-is-impaired-in-parkinson-s-disease
#5
Daniel S Joyce, Beatrix Feigl, Graham Kerr, Luisa Roeder, Andrew J Zele
Parkinson's disease (PD) is characterised by non-motor symptoms including sleep and circadian disruption. Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGC) transmit light signals to brain areas controlling circadian rhythms and the pupil light reflex. To determine if non-motor symptoms observed in PD are linked to ipRGC dysfunction, we evaluated melanopsin and rod/cone contributions to the pupil response in medicated participants with PD (n = 17) and controls (n = 12)...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769754/detection-of-bone-loss-via-subchondral-bone-analysis
#6
Jean-Baptiste Vimort, Antonio Ruellas, Jack Prothero, J S Marron, Matthew McCormick, Lucia Cevidanes, Erika Benavides, Beatriz Paniagua
To date, there is no single sign, symptom, or test that can clearly diagnose early stages of Temporomandibular Joint Osteoarthritis (TMJ OA). However, it has been observed that changes in the bone occur in early stages of this disease, involving structural changes both in the texture and morphometry of the bone marrow and the subchondral cortical plate. In this paper we present a tool to detect and highlight subtle variations in subchondral bone structure obtained from high resolution Cone Beam Computed Tomography (hr-CBCT) in order to help with detecting early TMJ OA...
February 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29762285/cone-beam-computed-tomography-guided-navigation-in-complex-osteotomies-improves-accuracy-at-all-competence-levels-a-study-assessing-accuracy-and-reproducibility-of-joint-sparing-bone-cuts
#7
Amir Sternheim, Aidin Kashigar, Michael Daly, Harley Chan, Jimmy Qiu, Robert Weersink, David Jaffray, Jonathan C Irish, Peter C Ferguson, Jay S Wunder
BACKGROUND: The objective of this study was to assess the accuracy and reproducibility of a novel cone-beam computed tomography (CBCT)-guided navigation system designed for osteotomies with joint-sparing bone cuts. METHODS: Eighteen surgeons participated in this study. First, 3 expert tumor surgeons resected bone tumors in 3 Sawbones tumor models identical to actual patient scenarios. They first performed these osteotomies without navigation and then performed them using a navigation system and 3-dimensional (3D) planning tools based on CBCT imaging...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29760175/modulation-of-receptor-protein-tyrosine-phosphatase-sigma-increases-chondroitin-sulfate-proteoglycan-degradation-through-cathepsin-b-secretion-to-enhance-axon-outgrowth
#8
Amanda Phuong Tran, Sapna Sundar, Meigen Yu, Bradley T Lang, Jerry Silver
Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. Chondroitin sulfate proteoglycans (CSPGs) are the major axon inhibitory matrix component that is increased within the lesion scar and in perineuronal nets around deafferented neurons. We have recently developed a novel peptide modulator (Intracellular Sigma Peptide or ISP) of the cognate receptor of CSPGs, protein tyrosine phosphatase sigma (RPTPσ), which has been shown to markedly improve sensorimotor function, micturition, and coordinated locomotor behavior in spinal cord contused rats...
May 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29758027/single-generation-effects-on-terpenoid-defenses-in-lodgepole-pine-populations-following-mountain-pine-beetle-infestation
#9
Sharleen L Balogh, Dezene P W Huber, B Staffan Lindgren
The recent mountain pine beetle outbreak in western Canada provides an opportunity to study the selection and heritability of tree defenses. We examined terpenoid-based defenses of seedling lodgepole pines which were offspring of mature trees subjected to high levels of mountain pine beetle selective pressure. Seedlings were grown from one of three types of cones: old cones on live trees; young cones on live trees; and cones on trees killed by beetles. Offspring thus represented crosses of non-surviving (NS) x surviving (S), S x S, and NS x NS parents, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29755286/characterisation-of-ground-motion-recording-stations-in-the-groningen-gas-field
#10
Rik Noorlandt, Pauline P Kruiver, Marco P E de Kleine, Marios Karaoulis, Ger de Lange, Antonio Di Matteo, Julius von Ketelhodt, Elmer Ruigrok, Benjamin Edwards, Adrian Rodriguez-Marek, Julian J Bommer, Jan van Elk, Dirk Doornhof
The seismic hazard and risk analysis for the onshore Groningen gas field requires information about local soil properties, in particular shear-wave velocity ( V S ). A fieldwork campaign was conducted at 18 surface accelerograph stations of the monitoring network. The subsurface in the region consists of unconsolidated sediments and is heterogeneous in composition and properties. A range of different methods was applied to acquire in situ V S values to a target depth of at least 30 m. The techniques include seismic cone penetration tests (SCPT) with varying source offsets, multichannel analysis of surface waves (MASW) on Rayleigh waves with different processing approaches, microtremor array, cross-hole tomography and suspension P-S logging...
2018: Journal of Seismology
https://www.readbyqxmd.com/read/29753854/occurrence-of-phosphenes-in-patients-undergoing-proton-beam-therapy-for-ocular-tumor
#11
Thibaud Mathis, Petter Hofverberg, Jean-Pierre Caujolle, Joël Hérault, Cécilia Leal, Celia Maschi, Benoit Delaunay, Stéphanie Baillif, Laurent Kodjikian, Juliette Thariat
PURPOSE: Phosphenes are frequently reported by patients irradiated in the head and neck area. The aim of the present study was to characterize and investigate potential mechanisms of proton beam therapy (PBT)-induced phosphenes in a large population of patients undergoing PBT for ocular tumors. DESIGN: Prospective cohort study METHODS: Consecutive patients who underwent PBT in a single center were included. Immediately after the first session, all patients completed a questionnaire collecting information about the presence of phosphenes as well as their color, shape, and duration...
May 10, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29751575/facile-fabrication-of-a-pdms-stearic-acid-kaolin-coating-on-lignocellulose-composites-with-superhydrophobicity-and-flame-retardancy
#12
Zhe Wang, Xiaoping Shen, Temeng Qian, Junjie Wang, Qingfeng Sun, Chunde Jin
The disadvantages such as swelling after absorbing water and flammability restrict the widespread applications of lignocellulose composites (LC). Herein, a facile and effective method to fabricate superhydrophobic surfaces with flame retardancy on LC has been investigated by coating polydimethylsiloxane (PDMS) and stearic acid (STA) modified kaolin (KL) particles. The as-prepared coatings on the LC exhibited a good repellency to water (a contact angle = 156°). Owing to the excellent flame retardancy of kaolin particles, the LC coated with PDMS@STA-KL displayed a good flame retardancy during limiting oxygen index and cone calorimeter tests...
May 3, 2018: Materials
https://www.readbyqxmd.com/read/29751069/extrafoveally-applied-flashing-light-affects-contrast-thresholds-of-achromatic-and-s-cone-isolating-but-not-l-m-cone-modulated-stimuli
#13
A Őze, A Puszta, P Buzás, P Kóbor, G Braunitzer, A Nagy
Flashing light stimulation is often used to investigate the visual system. However, the magnitude of the effect of this stimulus on the various subcortical pathways is not well investigated. The signals of conscious vision are conveyed by the magnocellular, parvocellular and koniocellular pathways. Parvocellular and koniocellular pathways (or more precisely, the L-M opponent and S-cone isolating channels) can be accessed by isoluminant red-green (L-M) and S-cone isolating stimuli, respectively. The main goal of the present study was to explore how costimulation with strong white extrafoveal light flashes alters the perception of stimuli specific to these pathways...
May 8, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29747684/efficacy-of-a-novel-mode-of-action-of-an-indoor-residual-spraying-product-sumishield%C3%A2-50wg-against-susceptible-and-resistant-populations-of-anopheles-gambiae-s-l-in-benin-west-africa
#14
Fiacre R Agossa, Gil G Padonou, Come Z Koukpo, Jacques Zola-Sahossi, Roseric Azondekon, Osei K Akuoko, Juniace Ahoga, Boris N'dombidje, Bruno Akinro, Arsene Jacques Y H Fassinou, Michel Sezonlin, Martin C Akogbeto
BACKGROUND: Scale-up of the distribution of long-lasting insecticide-treated bed nets and indoor residual spraying with insecticides over the last decade have contributed to the considerable decrease of malaria morbidity and mortality in sub-Saharan Africa. Due to the increasing pyrethroid resistance intensity and the spread of carbamate resistance in Anopheles gambiae (s.s.) mosquitoes and the limited number of insecticides recommended by the WHO for vector control, alternative insecticide formulations for IRS with long-lasting residual activity are required to sustain the gains obtained in most malaria-endemic countries...
May 10, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29742455/supplementation-with-macular-carotenoids-improves-visual-performance-of-transgenic-mice
#15
Binxing Li, Gregory T Rognon, Ty Mattinson, Preejith P Vachali, Aruna Gorusupudi, Fu-Yen Chang, Arunkumar Ranganathan, Kelly Nelson, Evan W George, Jeanne M Frederick, Paul S Bernstein
Carotenoid supplementation can improve human visual performance, but there is still no validated rodent model to test their effects on visual function in laboratory animals. We recently showed that mice deficient in β-carotene oxygenase 2 (BCO2) and/or β-carotene oxygenase 1 (BCO1) enzymes can accumulate carotenoids in their retinas, allowing us to investigate the effects of carotenoids on the visual performance of mice. Using OptoMotry, a device to measure visual function in rodents, we examined the effect of zeaxanthin, lutein, and β-carotene on visual performance of various BCO knockout mice...
May 6, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29729009/advanced-collapsed-cone-engine-dose-calculations-in-tissue-media-for-coms-eye-plaques-loaded-with-i-125-seeds
#16
Hali Morrison, Geetha Menon, Matthew P Larocque, Bob van Veelen, Yury Niatsetski, Ezekiel Weis, Ron S Sloboda
PURPOSE: To investigate the dose calculation accuracy of the Advanced Collapsed cone Engine (ACE) algorithm for ocular brachytherapy using a COMS plaque loaded with I-125 seeds for two heterogeneous patient tissue scenarios. METHODS: The Oncura model 6711 I-125 seed and 16 mm COMS plaque were added to a research version (v4.6) of the Oncentra® Brachy (OcB) treatment planning system (TPS) for dose calculations using ACE. Treatment plans were created for two heterogeneous cases: (i) a voxelized eye phantom comprising realistic eye materials and densities and (ii) a patient CT dataset with variable densities throughout the dataset...
May 4, 2018: Medical Physics
https://www.readbyqxmd.com/read/29722296/reconstruction-of-difference-rod-imaging-for-cone-beam-ct-neuro-angiography
#17
Pengwei Wu, Joseph Webster Stayman, Michael Mow, Wojciech Zbijewski, Alejandro Sisniega, Nafi Aygun, Robert Stevens, David H Foos, Xiaohui Wang, Jeffrey H Siewerdsen
Timely evaluation of neurovasculature via CT angiography (CTA) is critical to detection of pathology such as ischemic stroke. Cone-beam CTA (CBCT-A) systems provide potential advantages in timely use at the point-of-care, although challenges of a relatively slow gantry rotation speed introduce tradeoffs among image quality, data consistency, and data sparsity. This work describes and evaluates a new reconstruction-of-difference (RoD) approach that is robust to such challenges.
 Methods: A fast digital simulation framework was developed to test the performance of RoD over standard reference reconstruction methods like filtered back-projection (FBP) and penalized likelihood (PL) over a broad range of imaging conditions, grouped into three scenarios to test the trade-off between data consistency, data sparsity and peak contrast...
May 3, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29721988/role-of-sirtuins-in-retinal-function-under-basal-conditions
#18
Jonathan B Lin, Shunsuke Kubota, Raul Mostoslavsky, Rajendra S Apte
Sirtuins are NAD+ -dependent enzymes that govern cellular homeostasis by regulating the acylation status of their diverse target proteins. We recently demonstrated that both rod and cone photoreceptors rely on NAMPT-mediated NAD+ biosynthesis to meet their energetic requirements. Moreover, we found that this NAD+ -dependent retinal homeostasis relies, in part, on maintenance of optimal activity of the mitochondrial sirtuins and of SIRT3 in particular. Nonetheless, it is unknown whether other sirtuin family members also play important roles in retinal homeostasis...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29721981/constitutive-activation-mutant-mtor-promote-cone-survival-in-retinitis-pigmentosa-mice
#19
Ammaji Rajala, Yuhong Wang, Raju V S Rajala
Studies form our laboratory and others show that the oncogenic tyrosine kinase and serine threonine kinase signaling pathways are essential for cone photoreceptor survival. These pathways are downregulated in mouse models of retinal degenerative diseases. In the present study, we found that activation mutants of mTOR delayed the death of cones in a mouse model of retinal degeneration. These studies suggest that oncogenic protein kinases may be useful as therapeutic agents to treat retinal degenerations that affect cones...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29721954/identifying-key-networks-linked-to-light-independent-photoreceptor-degeneration-in-visual-arrestin-1-knockout-mice
#20
Hwa Sun Kim, Shun-Ping Huang, Eun-Jin Lee, Cheryl Mae Craft
When visual arrestin 1 (ARR1, S-antigen, 48 KDa protein) was genetically knocked out in mice (original Arr1 -/- , designated Arr1 -/-A ), rod photoreceptors degenerated in a light-dependent manner. Subsequently, a light-independent cone dystrophy was identified with minimal rod death in ARR1 knockout mice (Arr1 -/-A Arr4 +/+ , designated Arr1 -/-B ), which were F2 littermates from breeding the original Arr1 -/-A and cone arrestin knockout 4 (Arr4 -/- ) mice. To resolve the genetic and phenotypic differences between the two ARR1 knockouts, we performed Affymetrix™ exon array analysis to focus on the potential differential gene expression profile and to explore the molecular and cellular pathways leading to this observed susceptibility to cone dystrophy in Arr1 -/-B compared to Arr1 -/-A or control Arr1 +/+ Arr4 +/+ (wild type [WT])...
2018: Advances in Experimental Medicine and Biology
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