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https://www.readbyqxmd.com/read/28740757/using-electroretinograms-and-multi-model-inference-to-identify-spectral-classes-of-photoreceptors-and-relative-opsin-expression-levels
#1
Nicolas Lessios
Understanding how individual photoreceptor cells factor in the spectral sensitivity of a visual system is essential to explain how they contribute to the visual ecology of the animal in question. Existing methods that model the absorption of visual pigments use templates which correspond closely to data from thin cross-sections of photoreceptor cells. However, few modeling approaches use a single framework to incorporate physical parameters of real photoreceptors, which can be fused, and can form vertical tiers...
2017: PeerJ
https://www.readbyqxmd.com/read/28729369/pigmentary-retinopathy-rod-cone-dysfunction-and-sensorineural-deafness-associated-with-a-rare-mitochondrial-trna-lys-m-8340g-a-gene-variant
#2
Jaidip S Gill, Steven A Hardy, Emma L Blakely, Sila Hopton, Andrea H Nemeth, Carl Fratter, Joanna Poulton, Robert W Taylor, Susan M Downes
BACKGROUND/AIM: The rare mitochondrial DNA (mtDNA) variant m.8340G>A has been previously reported in the literature in a single, sporadic case of mitochondrial myopathy. In this report, we aim to investigate the case of a 39-year-old male patient with sensorineural deafness who presented to the eye clinic with nyctalopia, retinal pigmentary changes and bilateral cortical cataracts. METHODS: The patient was examined clinically and investigated with autofluorescence, full-field electroretinography, electro-oculogram and dark adaptometry...
July 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28728170/a-normative-data-set-for-the-clinical-assessment-of-achromatic-and-chromatic-contrast-sensitivity-using-a-qcsf-approach
#3
Yeon Jin Kim, Alexandre Reynaud, Robert F Hess, Kathy T Mullen
Purpose: The measurement of achromatic sensitivity has been an important tool for monitoring subtle changes in vision as the result of disease or response to therapy. In this study, we aimed to provide a normative data set for achromatic and chromatic contrast sensitivity functions within a common cone contrast space using an abbreviated measurement approach suitable for clinical practice. In addition, we aimed to provide comparisons of achromatic and chromatic binocular summation across spatial frequency...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28722180/a-generic-tg-186-shielded-applicator-for-commissioning-model-based-dose-calculation-algorithms-for-high-dose-rate-192-ir-brachytherapy
#4
Yunzhi Ma, Javier Vijande, Facundo Ballester, Åsa Carlsson Tedgren, Domingo Granero, Annette Haworth, Firas Mourtada, Gabriel Paiva Fonseca, Kyveli Zourari, Panagiotis Papagiannis, Mark J Rivard, Frank André Siebert, Ron S Sloboda, Ryan Smith, Marc J P Chamberland, Rowan M Thomson, Frank Verhaegen, Luc Beaulieu
PURPOSE: A joint working group was created by the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) with the charge, among others, to develop a set of well-defined test case plans and perform model-based dose calculation algorithms (MBDCA) dose calculations and comparisons. Its main goal is to facilitate a smooth transition from the AAPM Task Group No. 43 (TG-43) dose calculation formalism, widely being used in clinical practice for brachytherapy, to the one proposed by Task Group No...
July 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28717717/management-and-care-of-women-with-invasive-cervical-cancer-american-society-of-clinical-oncology-resource-stratified-clinical-practice-guideline
#5
Linus T Chuang, Sarah Temin, Rolando Camacho, Alfonso Dueñas-Gonzalez, Sarah Feldman, Murat Gultekin, Vandana Gupta, Susan Horton, Graciela Jacob, Elizabeth A Kidd, Kennedy Lishimpi, Carolyn Nakisige, Joo-Hyun Nam, Hextan Yuen Sheung Ngan, William Small, Gillian Thomas, Jonathan S Berek
PURPOSE: To provide evidence-based, resource-stratified global recommendations to clinicians and policymakers on the management and palliative care of women diagnosed with invasive cervical cancer. METHODS: ASCO convened a multidisciplinary, multinational panel of cancer control, medical and radiation oncology, health economic, obstetric and gynecologic, and palliative care experts to produce recommendations reflecting resource-tiered settings. A systematic review of literature from 1966 to 2015 failed to yield sufficiently strong quality evidence to support basic- and limited-resource setting recommendations; a formal consensus-based process was used to develop recommendations...
October 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717625/assessment-of-different-fitting-methods-for-in-vivo-bi-component-t2-analysis-of-human-patellar-tendon-in-magnetic-resonance-imaging
#6
Fang Liu, Richard Kijowski
PURPOSE: To investigate the robustness of four fitting methods for bi-component effective spin-spin T2 (T2(*)) relaxation time analysis of human patellar tendon. METHODS: A three-dimensional (3D) cone ultra-short echo-time (UTE) sequence was performed on the knees of ten healthy volunteers at 3.0T. Four fitting methods incorporating either Gaussian or Rician noise distribution were used for voxel-by-voxel bi-component T2(*) analysis of the patellar tendon. The T2(*) for the short relaxing (T(*)*,s ) and long relaxing (T(*)2,l ) water components and the fraction of the short relaxing water component (fs ) were measured, and different fitting methods were compared using Friedman's and Wilcoxon signed rank tests...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28716474/cone-beam-computed-tomography-evaluation-of-midpalatal-suture-maturation-in-adults
#7
F Angelieri, L Franchi, L H S Cevidanes, J R Gonçalves, M Nieri, L M Wolford, J A McNamara
The aim of this study was to evaluate midpalatal suture maturation in adults, as observed in cone beam computed tomography (CBCT) images. CBCT scans from 78 subjects (64 female and 14 male, age range from 18 to 66 years) were evaluated. Midpalatal suture maturation was verified on the central cross-sectional axial slice in the superior-inferior dimension of the palate, using methods validated previously. Intra-examiner agreement was analyzed by weighted kappa test. Multinomial logistic regression was used to test whether sex and chronological age (adults <30 years or ≥30 years) could be used as a predictor for the maturational stages of the midpalatal suture...
July 14, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28708910/influence-of-the-posterior-mandible-ridge-morphology-on-virtual-implant-planning
#8
German O Gallucci, Shirin Khoynezhad, Alfa I Yansane, Jacob Taylor, Daniel Buser, Bernard Friedland
PURPOSE: The purpose of this study was to examine the anatomy of the mandibular posterior region to develop an anatomical categorization for implant-prosthodontic planning. MATERIALS AND METHODS: Using cone beam computed tomography scans, 313 cross-sectional views of edentulous posterior mandibular sites were evaluated with respect to the anatomical ridge morphology. Virtual implant planning was performed, and the need for bone grafting was assessed. The level of complexity for planning implants in those positions was assessed...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28707526/diagnostic-validity-of-periapical-radiography-and-cbct-for-assessing-periapical-lesions-that-persist-after-endodontic-surgery
#9
Casper Kruse, Rubens Spin-Neto, Jesper Reibel, Ann Wenzel, Lise-Lotte Kirkevang
OBJECTIVES: Traditionally, healing after surgical endodontic retreatment (SER); i.e. apicectomy with or without a retrograde filling, is assessed in periapical radiographs (PR). Recently, the use of Cone Beam CT (CBCT) has increased within endodontics. Generally, CBCT detects more periapical lesions than PR, but basic research on the true nature of these lesions is missing. The objective was to assess the diagnostic validity of PR and CBCT for determining inflammation in SER-cases that were re-operated (SER-R) due to unsuccessful healing, using histology of the periapical lesion as reference for inflammation...
July 14, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28706560/experimental-realization-and-characterization-of-an-electronic-lieb-lattice
#10
Marlou R Slot, Thomas S Gardenier, Peter H Jacobse, Guido C P van Miert, Sander N Kempkes, Stephan J M Zevenhuizen, Cristiane Morais Smith, Daniel Vanmaekelbergh, Ingmar Swart
Geometry, whether on the atomic or nanoscale, is a key factor for the electronic band structure of materials. Some specific geometries give rise to novel and potentially useful electronic bands. For example, a honeycomb lattice leads to Dirac-type bands where the charge carriers behave as massless particles [1]. Theoretical predictions are triggering the exploration of novel 2D geometries [2-10], such as graphynes, Kagomé and the Lieb lattice. The latter is the 2D analogue of the 3D lattice exhibited by perovskites [2]; it is a square-depleted lattice, which is characterised by a band structure featuring Dirac cones intersected by a flat band...
July 2017: Nature Physics
https://www.readbyqxmd.com/read/28705329/relationship-between-cone-beam-ct-technique-and-diagnostic-usefulness-in-patients-undergoing-embolotherapy-for-hepatocellular-carcinoma
#11
D Gutierrez, R Kishore Gurajala, B Kapoor, R Setser, K Karuppasamy
AIM: To determine the effect of different numbers of projection images in C-arm cone-beam computed tomography (CBCT) on diagnostic content and image quality in patients undergoing angiographic embolotherapy for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A total of 29 patients who underwent contrast-enhanced conventional multidetector CT (MDCT) within 6 weeks prior to CBCT acquired during embolotherapy for HCC between 2010 and 2013 were included in the study...
July 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28697496/spatially-resolved-spectral-sensitivities-as-a-potential-read-out-parameter-in-clinical-gene-therapeutic-trials
#12
Birgit Lorenz, Erika Wegscheider, Christian Hamel, Markus N Preising, Knut Stieger
PURPOSE: Spatially resolved functional assessment of rods and cones under photopic and scotopic conditions is desirable to evaluate the treatment outcome of gene therapeutic applications in inherited retinal disorders, such as early- onset severe retinal dystrophy (EOSRD) or achromatopsia. METHODS: A sample of 3 healthy subjects, 6 patients with RPE65 deficiency (aged 11-45 years), and 3 patients with cone dysfunction disorders underwent spectral sensitivity testing (SST) under conditions of dark and light adaptation using a Humphrey Field Analyzer modified perimeter...
July 12, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28696750/unveiling-extreme-anisotropy-in-elastic-structured-media
#13
G Lefebvre, T Antonakakis, Y Achaoui, R V Craster, S Guenneau, P Sebbah
Periodic structures can be engineered to exhibit unique properties observed at symmetry points, such as zero group velocity, Dirac cones, and saddle points; identifying these and the nature of the associated modes from a direct reading of the dispersion surfaces is not straightforward, especially in three dimensions or at high frequencies when several dispersion surfaces fold back in the Brillouin zone. A recently proposed asymptotic high-frequency homogenization theory is applied to a challenging time-domain experiment with elastic waves in a pinned metallic plate...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28692722/effective-dynamic-range-and-retest-reliability-of-dark-adapted-two-color-fundus-controlled-perimetry-in-patients-with-macular-diseases
#14
Maximilian Pfau, Moritz Lindner, Philipp L Müller, Johannes Birtel, Robert P Finger, Wolf M Harmening, Monika Fleckenstein, Frank G Holz, Steffen Schmitz-Valckenberg
Purpose: To determine the effective dynamic range (EDR), retest reliability, and number of discriminable steps (DS) for mesopic and dark-adapted two-color fundus-controlled perimetry (FCP) using the S-MAIA (Scotopic-Macular Integrity Assessment) "micro-perimeter." Methods: In this prospective cross-sectional study, each of the 52 eyes of 52 subjects with various macular diseases (mean age 62.0 ± 16.9 years; range, 19.1-90.1 years) underwent duplicate mesopic (achromatic stimuli, 400-800 nm), dark-adapted cyan (505 nm), and dark-adapted red (627 nm) FCP using a grid of 61 stimuli covering 18° of the central retina...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28691459/periodontal-microbioma-and-rheumatoid-arthritis-the-role-of-porhyromonas-gingivalis
#15
L Azzi, S Rania, R Vinci, F Spadari, F Croveri, C Scognamiglio, D Farronato, L Tettamanti, A Tagliabue, J Silvestre-Rangil, C Bellintani
Rheumatoid Arthritis is a disease, which can be described as an autoimmune response after molecular mimicry caused by infective agents. The current study aims at evaluating the correlation between Rhematoid Arthritis (RA) and Periodontal Disease (PD), with special attention to the microbioma detected in the gums. Thirty-four patients with RD were recruited into the current study. Among rheumatic parameters, Rheumatoid Factor (RF), anti-citrullinated protein antibody (CCP), HLA-BDR1 and DAS28 were collected...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28690901/use-of-cone-beam-computed-tomography-in-the-diagnosis-and-treatment-of-an-unusual-canine-abnormality
#16
Archana Gopalakrishnan, K Unnikrishna, Anita Balan, P S Haris
Diagnosis and treatment planning are important for successful endodontic treatment. We report a 24-year old male who presented to the Government Dental College in Kozhikode, Kerala, India, in 2015 with pain in his right upper canine. A digital periapical radiograph indicated the presence of a supernumerary tooth superimposing the root of the canine. However, cone-beam computed tomography (CBCT) confirmed that the supernumerary tooth was an illusion and that the canine root had a sharp invagination involving the labial and pulpal dentin surfaces, with evidence of periapical bone destruction...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28689025/venom-derived-peptide-inhibitors-of-voltage-gated-potassium-channels
#17
REVIEW
Raymond S Norton, K George Chandy
Voltage-gated potassium channels play a key role in human physiology and pathology. Reflecting their importance, numerous channelopathies have been characterised that arise from mutations in these channels or from autoimmune attack on the channels. Voltage-gated potassium channels are also the target of a broad range of peptide toxins from venomous organisms, including sea anemones, scorpions, spiders, snakes and cone snails; many of these peptides bind to the channels with high potency and selectivity. In this review we describe the various classes of peptide toxins that block these channels and illustrate the broad range of three-dimensional structures that support channel blockade...
July 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28688906/effects-of-photopic-and-cirtopic-illumination-on-steady-state-pupil-sizes
#18
Feng Rao, A H S Chan, Xi-Fang Zhu
The conventional view was that cones are responsible for pupil constriction in photopic lighting conditions. With the discovery of intrinsically photosensitive retinal ganglion cells (ipRGC), it was found that signals from ipRGCs along with cones mediated the pupil light reflex in photopic lighting conditions. Although both signals contributed, it was unclear how these signals were summed. In the work reported here, steady-state pupil size was measured with an infrared camera under LED lighting conditions with different color temperatures and luminance...
July 11, 2017: Vision Research
https://www.readbyqxmd.com/read/28688493/computer-aided-diagnosis-of-periapical-cyst-and-keratocystic-odontogenic-tumor-on-cone-beam-computed-tomography
#19
E Yilmaz, T Kayikcioglu, S Kayipmaz
BACKGROUND AND OBJECTIVES: In this article, we propose a decision support system for effective classification of dental periapical cyst and keratocystic odontogenic tumor (KCOT) lesions obtained via cone beam computed tomography (CBCT). CBCT has been effectively used in recent years for diagnosing dental pathologies and determining their boundaries and content. Unlike other imaging techniques, CBCT provides detailed and distinctive information about the pathologies by enabling a three-dimensional (3D) image of the region to be displayed...
July 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28673493/variations-of-palatal-canal-morphology-in-maxillary-molars-a-case-series-and-literature-review
#20
Ali Nosrat, Prashant Verma, M Lamar Hicks, S Craig Schneider, Ali Behnia, Adham A Azim
A series of challenging cases with unusual canal anatomy in the palatal roots of maxillary first and second molars is presented. A review of the literature was done to elucidate the prevalence of anatomic variations in the palatal canal of maxillary first and second molars. An uncertain or indefinite radiographic appearance of the palatal canal, or eccentric deviation of the master cone or previous root canal filling was considered an indication of a bifurcated palatal canal. Five maxillary molars with a bifurcated palatal canal were identified...
June 30, 2017: Journal of Endodontics
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