Read by QxMD icon Read

S cone

K Lee, A Priezzhev, S Shin, Y Francois, I Meglinski
BACKGROUND: The novel measure of the red blood cells (RBC) aggregation (RBC-A) - the critical (minimum) shear stress (CSS) to prevent the cells from aggregation was found to be a promising clinically significant parameter. However, the absolute values of this parameter were found to change significantly depending on the shearing geometry (cup-and-bob, cone-plate or microchannel-flow) and have different temperature dependences along with it. The direct confirmation of these dependences aimed to find out the correct values is still pending...
October 18, 2016: Clinical Hemorheology and Microcirculation
Zhongqiu Chen, Wen Ling, Guangdong Shang
Pseudomonas putida KT2440 is a saprophytic, generally recognized as safe microorganism that plays important roles in the biodegradation and production of value-added chemicals. Chromosomal gene deletion of P. putida KT2440 usually involves time-consuming gene coning, conjugal transfer and counterselection. Recently, we developed a P. putida KT2440 markerless gene deletion method based on recombineering and Cre/loxP site-specific recombination. PCR-based λ Red recombineering circumvents the tedious cloning steps and is more amenable to high-throughput manipulation...
October 7, 2016: FEMS Microbiology Letters
Rujuta Katkar, Douglas D Steffy, Marcel Noujeim, S Thomas Deahl, Hassem Geha
OBJECTIVES: The aim of this study was to evaluate the effect of milliamperage, number of basis images, and export slice thickness on contrast-to-noise ratio (CNR) and confidence in detecting mandibular canal. STUDY DESIGN: Two phantoms were used. Each phantom consisted of a dry mandible with an epoxy resin bone tissue substitute block and a water-equivalent block, submerged in water. Each mandible was scanned with a Morita 3D Accuitomo cone beam computed tomography (CBCT) machine (Morita, Kyoto, Japan)...
November 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Pavitra Ramachandran, Vivian Lee, Zhangyong Wei, Ji Yun Song, Giulia Casal, Therese Cronin, Keirnan Willett, Rachel Huckfeldt, Jessica I W Morgan, Tomas S Aleman, Albert M Maguire, Jean Bennett
Within the next decade, we will see many gene therapy clinical trials for eye diseases progress, which may lead to treatments for thousands of visually impaired people around the world. To target retinal diseases that affect specific cell types, several recombinant adeno-associated virus (AAV) serotypes have been generated and used successfully in pre-clinical mouse studies. Because there are numerous anatomic, and physiologic differences between the eyes of mice and 'men' and because surgical delivery approaches and immunologic responses also differ between these species, we evaluated the transduction characteristics of two promising new serotypes AAV7m8 and AAV8BP2, in retinas of animals that are most similar to those of humans: non-human primates (NHPs)...
October 18, 2016: Human Gene Therapy
J S Blumenthal-Barby, Peter A Ubel
No abstract text is available yet for this article.
November 2016: American Journal of Bioethics: AJOB
Orkun Akin, S Lawrence Zipursky
Axon guidance is proposed to act through a combination of long- and short-range attractive and repulsive cues. The ligand-receptor pair, Netrin (Net) and Frazzled (Fra) (DCC, Deleted in Colorectal Cancer, in vertebrates), is recognized as the prototypical effector of chemoattraction, with roles in both long- and short-range guidance. In the Drosophila visual system, R8 photoreceptor growth cones were shown to require Net-Fra to reach their target, the peak of a Net gradient. Using live imaging, we show, however, that R8 growth cones reach and recognize their target without Net, Fra, or Trim9, a conserved binding partner of Fra, but do not remain attached to it...
October 15, 2016: ELife
Vikneswary Batumalai, Penny Phan, Callie Choong, Lois Holloway, Geoff P Delaney
INTRODUCTION: To compare the differences in setup errors measured with electronic portal image (EPI) and cone-beam computed tomography (CBCT) in patients undergoing tangential breast radiotherapy (RT). Relationship between setup errors, body mass index (BMI) and breast size was assessed. METHODS: Twenty-five patients undergoing postoperative RT to the breast were consented for this study. Weekly CBCT scans were acquired and retrospectively registered to the planning CT in three dimensions, first using bony anatomy for bony registration (CBCT-B) and again using breast tissue outline for soft tissue registration (CBCT-S)...
May 31, 2016: Journal of Medical Radiation Sciences
M Corton, A Avila-Fernández, L Campello, M Sánchez, B Benavides, M I López-Molina, L Fernández-Sánchez, R Sánchez-Alcudia, L R J da Silva, N Reyes, E Martín-Garrido, O Zurita, P Fernández-San José, R Pérez-Carro, F García-García, J Dopazo, B García-Sandoval, N Cuenca, C Ayuso
Retinitis pigmentosa (RP), the most frequent form of inherited retinal dystrophy is characterized by progressive photoreceptor degeneration. Many genes have been implicated in RP development, but several others remain to be identified. Using a combination of homozygosity mapping, whole-exome and targeted next-generation sequencing, we found a novel homozygous nonsense mutation in SAMD11 in five individuals diagnosed with adult-onset RP from two unrelated consanguineous Spanish families. SAMD11 is ortholog to the mouse major retinal SAM domain (mr-s) protein that is implicated in CRX-mediated transcriptional regulation in the retina...
October 13, 2016: Scientific Reports
Natasha Pahuja, Nimisha R Kumar, Rushad Shroff, Rohit Shetty, Rudy M M A Nuijts, Anuprita Ghosh, Abhijit Sinha-Roy, Shyam S Chaurasia, Rajiv R Mohan, Arkasubhra Ghosh
Purpose: In this study, we elucidated the differential expression of a set of local molecular factors in ectatic cone area of the cornea to uncover a functional cause for focal corneal weakening characteristic of the keratoconus (KC) disease. Methods: All human corneal samples were collected after approval of Institutional Ethics Committee and informed consent. Keratoconus patients were classified based on clinical parameters, topographical features, and structural deformity...
October 1, 2016: Investigative Ophthalmology & Visual Science
Hadas Newman, Sergiu C Blumen, Itzhak Braverman, Rana Hanna, Beatrice Tiosano, Ido Perlman, Tamar Ben-Yosef
Purpose: To investigate the genetic basis for severe visual complaints by Bukharan Jewish patients with oculopharyngeal muscular dystrophy (OPMD). Methods: Polymerase chain reaction amplification and direct sequencing were used to test for NRL, PABPN1, and NR2E3 mutations. Complete ophthalmic examination included best-corrected visual acuity, biomicroscopic examination, optical coherence tomography, and fundus autofluorescence. Detailed electroretinography (ERG) testing was conducted including expanded International Society for Clinical Electrophysiology of Vision protocol for light-adapted and dark-adapted conditions, measurements of S-cone function, and ON-OFF light-adapted ERG...
October 1, 2016: Investigative Ophthalmology & Visual Science
Raphaël Mizzi, George A Michael
Over the past few decades, evidence has accumulated showing that, at subcortical levels, visual attention depends partly on the extrageniculate neural pathways, that is, those pathways that bypass the lateral geniculate nucleus and circumvent the primary visual cortex. Working in concert with neuroscience, experimental psychology has contributed considerably to the understanding of the role these pathways play through the use of 3 behavioral cues: nasal-temporal asymmetries, responses to S-cone stimuli, and responses to perceptually suppressed stimuli...
October 10, 2016: Psychological Review
Arvind Hariharan, N R Diwakar, K Jayanthi, H M Hema, S Deepukrishna, Snehal R Ghaste
CONTEXT: This study compared digital two-dimensional (2D) lateral cephalograms and cone-beam computed tomography (CBCT) total and half-skull images for the reliability of cephalometric measurements. AIMS: (1) To compare the accuracy of cephalometric measurements and reproducibility between the digital and CBCT cephalograms in the Indian population. (2) To compare interobserver variability in landmark identification through their cephalometric measurements by comparing different imaging modalities (CBCT total skull, CBCT half-skull, and conventional lateral cephalogram)...
July 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Guozhen Luo, Joseph S Neimat, Anthony Cmelak, Austin N Kirschner, Albert Attia, Manuel Morales-Paliza, George X Ding
PURPOSE: To report on radiosurgery delivery positioning accuracy in the treatment of tremor patients with frameless image guided radiosurgery using the linear accelerator (LINAC) based ExacTrac system and to describe quality assurance (QA) procedures used. METHODS AND MATERIALS: Between 2010 and 2015, 20 patients underwent radiosurgical thalamotomy targeting the ventral intermediate nucleus for the treatment of severe tremor. The median prescription dose was 140 Gy (range, 120-145 Gy) in a single fraction...
August 20, 2016: Practical Radiation Oncology
V de C Machado, B R Chrcanovic, M B Felippe, L R C Manhães Júnior, P S P de Carvalho
The aim of this study was to verify the presence, spatial location, and calibre of the accessory canals (AC) of the canalis sinuosus by cone beam computed tomography, and their relationship to the anterior maxilla. This retrospective analysis included the scans of 1000 subjects. Parameters registered were sex, age, number of AC, presence or absence of AC with a diameter <1.0mm, AC diameter (only for AC with a diameter >1.0mm), and AC location in relation to the adjacent teeth. Males showed a statistically higher frequency of AC than females...
October 5, 2016: International Journal of Oral and Maxillofacial Surgery
Li-Chun Xu, Aijun Du, Liangzhi Kou
The recent synthesis of monolayer borophene (triangular boron monolayer) on a substrate has opened the era of boron nanosheets (Science, 2015, 350, 1513), but the structural instability and a need to explore the novel physical properties are still open issues. Here we demonstrated that borophene can be stabilized by full surface hydrogenation (borophane), from first-principles calculations. Most interestingly, our calculations show that borophane has direction-dependent Dirac cones, which are mainly caused by the in-plane px and py orbitals of boron atoms...
October 5, 2016: Physical Chemistry Chemical Physics: PCCP
Hazem Mahmoud Al-Mandeel, Emad Sagr, Khalid Sait, Hassan Mohamed Latifah, Abdulaziz Al-Obaid, Ismail A Al-Badawi, Abdulmohsen O Alkushi, Hany Salem, Nada S Massoudi, Holger Schunemann, Reem A Mustafa, Romina Brignardello-Petersen
BACKGROUND: Cervical cancer is the third most common gynecological malignancy in Saudi women with an estimated incidence rate of 1.9 cases per 100 000 women-years. More than 40% of cervical cancer cases are diagnosed at advanced stages due to lack of a routine screening program in Saudi Arabia. Thus, national guidelines for routine screening and treatment of precancerous cervical lesions are needed. METHODS: The Saudi Centre for Evidence-Based Healthcare invited a panel of local experts and partnered them with a team from McMaster University in Canada for methodological support, to develop national clinical practice guidelines on the screening and treatment of precancerous lesions for cervical cancer...
September 2016: Annals of Saudi Medicine
Lauw J Klaassen, Wim de Graaff, Jorrit B Van Asselt, Jan Klooster, Maarten Kamermans
The functional and morphological connectivity between various horizontal cell (HC) types (H1, H2, H3 and H4), and photoreceptors was studied in zebrafish retina. Since HCs are strongly coupled by gap-junctions and feedback from HCs to photoreceptors strongly depends on connexin (Cx) hemichannels we characterized the various HC Cxs (Cx52.6, Cx52.7, Cx52.9 and Cx55.5) in Xenopus oocytes. All Cxs formed hemichannels which were conducting at physiological membrane potentials. The Cx hemichannels differed in kinetic properties and voltage dependence, allowing for specific tuning of the coupling of HCs and the feedback signal from HCs to cones...
October 5, 2016: Journal of Neurophysiology
Brian Chang, Matthew Croson, Lorian Straker, Sean Gart, Carla Dove, John Gerwin, Sunghwan Jung
In nature, several seabirds (e.g., gannets and boobies) dive into water at up to 24 m/s as a hunting mechanism; furthermore, gannets and boobies have a slender neck, which is potentially the weakest part of the body under compression during high-speed impact. In this work, we investigate the stability of the bird's neck during plunge-diving by understanding the interaction between the fluid forces acting on the head and the flexibility of the neck. First, we use a salvaged bird to identify plunge-diving phases...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
Anna Maria Ierardi, Filippo Piacentino, Francesca Giorlando, Alberto Magenta Biasina, Alessandro Bacuzzi, Raffaele Novario, Gianpaolo Carrafiello
OBJECTIVE: To demonstrate the feasibility of percutaneous nucleoplasty procedures at L5/S1 level using cone beam CT (CBCT) and its associated image guidance technology for the treatment of lumbar disc herniation (LDH). MATERIALS AND METHODS: We retrospectively reviewed 25 cases (20 men, 5 women) of LDH at L5/S1 levels. CBCT as guidance imaging was chosen after a first unsuccessful fluoroscopy attempt that was related to complex anatomy (n = 15), rapid pathological changes due to degenerative diseases (n = 7) or both (n = 3)...
October 3, 2016: Skeletal Radiology
Patrycja Orlowska-Feuer, Jagoda S Jeczmien-Lazur, Hanna J Szkudlarek, Marian H Lewandowski
A subpopulation of olivary pretectal nucleus (OPN) neurons fire action potentials in a rhythmic manner with an eruption of activity occurring approximately every two minutes. These infra-slow oscillations depend critically on functional retinal input and are subject to modulation by light. Interestingly, the activity of photoreceptors is necessary for the emergence of the rhythm and while classic photoreceptors (rods and cones) are necessary in darkness and dim light, melanopsin photoreceptors are indispensable in bright light...
September 28, 2016: Neuroscience
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"