keyword
MENU ▼
Read by QxMD icon Read
search

Enterococcus faecalis

keyword
https://www.readbyqxmd.com/read/29778894/new-n-phenylpyrrolamide-dna-gyrase-b-inhibitors-optimization-of-efficacy-and-antibacterial-activity
#1
Martina Durcik, Denise Lovison, Žiga Skok, Cristina Durante Cruz, Päivi Tammela, Tihomir Tomašič, Davide Benedetto Tiz, Gábor Draskovits, Ákos Nyerges, Csaba Pál, Janez Ilaš, Lucija Peterlin Mašič, Danijel Kikelj, Nace Zidar
The ATP binding site located on the subunit B of DNA gyrase is an attractive target for the development of new antibacterial agents. In recent decades, several small-molecule inhibitor classes have been discovered but none has so far reached the market. We present here the discovery of a promising new series of N-phenylpyrrolamides with low nanomolar IC50 values against DNA gyrase, and submicromolar IC50 values against topoisomerase IV from Escherichia coli and Staphylococcus aureus. The most potent compound in the series has an IC50 value of 13 nM against E...
May 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29777835/combined-bacteriophages-and-antibiotics-as-an-efficient-therapy-against-vre-enterococcus-faecalis-in-a-mouse-model
#2
Daniel Gelman, Shaul Beyth, Vanda Lerrer, Karen Adler, Ronit Poradosu-Cohen, Shunit Coppenhagen-Glazer, Ronen Hazan
Clinical applications of bacteriophage therapy have been recently gathering significant attention worldwide, used mostly as rescue therapy in cases of near-fatal antibiotic failure. Thus, clinically relevant in-vivo models presenting both short- and long-term implications of phage therapy given as rescue treatment for fulminant infections are of highest importance. In this study, a cocktail consisting of two lytic bacteriophages was used to evaluate the therapeutic efficacy of phage therapy as a rescue treatment for severe septic peritonitis in a mouse model...
May 16, 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29774893/prevalence-and-antimicrobial-sensitivity-pattern-of-urinary-tract-infection-among-children-with-cerebral-palsy-moshi-tanzania
#3
Amon Ryakitimbo, Rune Philemon, Festo Mazuguni, Levina Msuya
Background: Urinary tract infection (UTI) in children with cerebral palsy (CP) is a challenging yet common clinical condition. Children with CP bare the greatest risk of contracting UTI because of their difficulties in neuromotor control which lead to delay of bladder control, causing incomplete bladder emptying and urine retention. Method: This was an analytical cross-sectional study that was conducted from September 2016 to March 2017 at Comprehensive Community Based Rehabilitation in Tanzania - Moshi and Kilimanjaro Christian Medical Centre Neurological Pediatrics Outpatient Clinic...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29773506/in-vitro-activity-of-salicylamide-derivatives-against-vancomycin-resistant-enterococci
#4
Sarka Pospisilova, Hana Michnova, Tereza Kauerova, Karel Pauk, Peter Kollar, Jarmila Vinsova, Ales Imramovsky, Alois Cizek, Josef Jampilek
A series of 13 salicylamide derivatives was assessed for antibacterial activity against three isolates of vancomycin-resistant Enterococcus faecalis (VRE) and Enterococcus faecalis ATCC 29212 as a quality standard. The minimum inhibitory concentration was determined by the broth microdilution method with subsequent subcultivation of aliquots to assess minimum bactericidal concentration. The growth kinetics was established by the time-kill assay. Ampicillin, ciprofloxacin, tetracycline and vancomycin were used as the reference antibacterial drugs...
May 14, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29772394/antimicrobial-resistance-and-genetic-lineages-of-faecal-enterococci-of-wild-birds-emergence-of-vana-and-vanb2-harboring-enterococcus-faecalis
#5
Houssem Ben Yahia, Sarra Chairat, Nabil Hamdi, Haythem Gharsa, Rym Ben Sallem, Sara Ceballos, Carmen Torres, Karim Ben Slama
Migrating birds have been implicated in pathogen dissemination over long-distances. The lack of data on birds' intestinal microbiota makes these animals a promising path to understand their potential role in the transmission of antibiotic resistant bacteria. This work aims to study the diversity of enterococci species and to analyze the antimicrobial resistant phenotypes/genotypes, as well as the genetic lineages of isolates obtained from faecal and pellet samples of colonial wild birds in Tunisia. Seventy-nine enterococci were recovered of 150 wild bird, after inoculation of samples in Slanetz-Bartley agar, and were identified as E...
May 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29772356/assessment-of-toxicity-and-differential-antimicrobial-activity-of-methanol-extract-of-rhizome-of-simaba-ferruginea-a-st-hil-and-its-isolate-canthin-6-one
#6
Vanessa Fátima Gazoni, Sikiru Olaitan Balogun, Karuppusamy Arunacham, Darley Maria Oliveira, Valdir Cechinel Filho, Samara Rosolem Lima, Edson Moleta Colodel, Ilsamar Mendes Soares, Sérgio Donizeti Ascêncio, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Simaba ferruginea A. St.-Hil., Simaroubaceae, popularly known as "calunga" is a typical subtropical shrub used in Central Brazil mainly for infection, anti-inflammatory, analgesic and gastric duodenal-ulcers. It presents in its composition the alkaloid canthin-6-one, an alkaloid indole β-carboxylic. AIM: This study aims to investigate the toxicity, antimicrobial activities of methanol extract of Simaba ferruginea (MESf) and canthin-6-one by using different experimental models...
May 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29767090/combined-effects-of-chitosan-and-microencapsulated-enterococcus-faecalis-cg1-0007-probiotic-supplementation-on-performance-and-diarrhea-incidences-in-enterotoxigenic-escherichia-coli-k88-challenged-piglets
#7
Kolawole Aluko, Deepak E Velayudhan, Ehsan Khafipour, Aike Li, Yulong Yin, Martin Nyachoti
The aim of this study was to investigate the combined effects of chitosan oligosaccharide (COS) and a microencapsulated Enterococcus faecalis CG1.0007 probiotic (PRO) on growth performance and diarrhea incidences in enterotoxigenic Escherichia coli (ETEC) K88+ challenged piglets in a 14-d study. Thirty piglets, 7.19 ± 0.52 kg initial BW weaned at 21 ± 1 d, were allotted to 5 treatment groups ( n =  6) consisting of a corn-soybean meal diet with no additive (negative control, NC), NC + 0.25% chlortetracycline (positive control, PC), NC + 400 mg/kg COS (COS), NC + 100 mg/kg PRO (PRO) and NC + a combination of COS and PRO (CPRO)...
December 2017: Animal nutrition
https://www.readbyqxmd.com/read/29760341/estimation-of-lactic-acid-bacterial-cell-number-by-dna-quantification
#8
Masaki Ishii, Yasuhiko Matsumoto, Kazuhisa Sekimizu
Lactic acid bacteria are provided by fermented foods, beverages, medicines, and supplements. Because the beneficial effects of medicines and supplements containing functional lactic acid bacteria are related to the bacterial cell number, it is important to establish a simple method for estimating the total number of lactic acid bacterial cells in the products for quality control. Almost all of the lactic acid bacteria in the products are dead, however, making it difficult to estimate the total number of lactic acid bacterial cells in the products using a standard colony-counting method...
2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29755627/molecular-diagnosis-of-bacterial-definite-infective-endocarditis-by-real-time-polymerase-chain-reaction
#9
Reza Faraji, Mostafa Behjati-Ardakani, Nooshin Faraji, Seyed Mohammad Moshtaghioun, Seyed Mehdi Kalantar, Ali Pedarzadeh, Hengameh Zandi, Mohammadtaghi Sarebanhassanabadi, Nastaran Ahmadi, Ali Dehghani Firoozabadi
Infective endocarditis (IE) can be diagnosed using the Duke criteria, which cannot be conclusive especially when the results of blood cultures are negative. This study aimed at using real-time polymerase chain reaction (PCR) technique to isolate bacteria present in whole blood samples of patients with definitive IE on the basis of the method designed in this study. This laboratory and test study was conducted on 20 whole blood samples taken from patients with definitive IE. Real-time PCR of the 16s rRNA was utilized to directly analyze whole blood samples to diagnose bacterial IE...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29752196/acute-focal-bacterial-nephritis-characterized-by-acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion
#10
Hiroshi Yamaguchi, Hiroaki Nagase, Yusuke Ito, Natsuki Matsunoshita, Makoto Mizutani, Takeshi Matsushige, Yusuke Ishida, Daisaku Toyoshima, Masashi Kasai, Hiroshi Kurosawa, Azusa Maruyama, Kazumoto Iijima
Acute focal bacterial nephritis (AFBN) is a localized bacterial infection of the kidney presenting as an inflammatory mass, and some patients show deterioration of clinical condition with neurological symptoms. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a syndrome that is characterized by biphasic seizures and impaired consciousness with reduced diffusion in the subcortical white matter on magnetic resonance imaging, typically observed between days 3 and 9 after clinical onset...
May 8, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29751263/synthesis-of-zno-nanoparticles-decorated-spindle-shaped-graphene-oxide-for-application-in-synergistic-antibacterial-activity
#11
Linlin Zhong, Huifang Liu, Monica Samal, Kyusik Yun
A novel spindle-shaped graphene oxide (GO) was performed by the self-assembly of graphene oxide in the DMF. Loading uniform ZnO nanoparticles on spindle-shaped GO is used to study antibacterial property. In the ZnO/GO composites, spindle-shaped GO possessed special structure that was crumpled together with a length of ~1.0 μm and a mean diameter of 100 nm, and spherical ZnO particles with a diameter of 50 nm were fully characterized by field-emission scanning electron microscope (FE-SEM), a high-resolution transmission electron microscope (HR-TEM) and X-ray diffraction (XRD)...
May 3, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29750765/ideal-and-actual-impact-of-rapid-diagnostic-testing-and-antibiotic-stewardship-on-antibiotic-prescribing-and-clinical-outcomes-in-children-with-positive-blood-cultures
#12
Caroline H Reuter, Hannah L Palac, Larry K Kociolek, Xiaotian T Zheng, Yusuf Y Chao, Rupal Patel, Sameer J Patel
BACKGROUND: Implementing matrix assisted laser desorption ionization time of flight (MALDI-TOF) and multiplex PCR (mPCR) has been associated with decreased mortality and hospital length of stay in adults, but the impact in pediatrics is less understood. METHODS: This pre-post quasi-experimental study compared antibiotic prescribing for positive blood cultures in patients ≤21 years collected in 2012 (pre-intervention) and in 2015 (after MALDI-TOF/mPCR). Time to effective and optimal antimicrobial therapy were evaluated using Cox proportional hazards regression...
May 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29746970/multiparticulate-based-thermosensitive-intra-pocket-forming-implants-for-better-treatment-of-bacterial-infections-in-periodontitis
#13
Sarita Kumari Yadav, Gayasuddin Khan, Monika Bansal, Sathish Thokala, Gunjan Vasant Bonde, Mansi Upadhyay, Brahmeshwar Mishra
Considering alarming projections in the prevalence of periodontitis, following study was undertaken to develop chitosan-vanillin cross-linked microspheres loaded in-situ gel (MLIG) implants containing ornidazole and doxycycline hyclate for the treatment of pocket infections. Firstly, microspheres were formulated and optimized using response surface methodology for particle size <50 μm, entrapment efficiency >80%, in-vitro drug release (T80% ) >7 days and acceptable mucoadhesion. Further, MLIG were optimized for gelation temperature of 34-37 °C and viscosity <1000 cps respectively...
May 7, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29744476/prostate-calcifications-a-case-series-supporting-the-microbial-biofilm-theory
#14
Tommaso Cai, Francesco Tessarolo, Iole Caola, Federico Piccoli, Giandomenico Nollo, Patrizio Caciagli, Sandra Mazzoli, Alessandro Palmieri, Paolo Verze, Gianni Malossini, Vincenzo Mirone, Truls E Bjerklund Johansen
Purpose: Prostate calcifications are a common finding during transrectal prostate ultrasound in both healthy subjects and patients, but their etiopathogenesis and clinical significance are not fully understood. We aimed to establish a new methodology for evaluating the role of microbial biofilms in the genesis of prostate calcifications. Materials and Methods: Ten consecutive patients who had undergone radical prostatectomy were enrolled in this study. All of the patients presented with prostate calcifications during transrectal ultrasound evaluation before surgery and underwent Meares-Stamey tests and clinical evaluation with the National Institutes of Health Chronic Prostatitis Symptom Index and the International Prostate Symptom Score...
May 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29744228/successful-treatment-of-high-level-aminoglycoside-resistant-enterococcus-faecalis-bacteremia-in-a-preterm-infant-with-ampicillin-and-cefotaxime
#15
Jennifer Tam, Santina J Lee, Vibhuti Shah, Shaun K Morris
Enterococcal bloodstream infections are usually treated with single-agent antibiotics. In persistent infections, synergistic combination therapy is often required with a beta-lactam and an aminoglycoside antibiotic. High-level aminoglycoside-resistant (HLAR) enterococci are increasingly prevalent and preclude the use of this combination. The use of ampicillin with a third-generation cephalosporin to treat endovascular HLAR Enterococcus infections is becoming more established in the adult population; however, the literature on treatment of such infections in children remains scarce...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29739905/loss-of-ethanolamine-utilization-in-enterococcus-faecalis-increases-gastrointestinal-tract-colonization
#16
Karan Gautam Kaval, Kavindra V Singh, Melissa R Cruz, Sruti DebRoy, Wade C Winkler, Barbara E Murray, Danielle A Garsin
Enterococcus faecalis is paradoxically a dangerous nosocomial pathogen and a normal constituent of the human gut microbiome, an environment rich in ethanolamine. E. faecalis carries the eut (ethanolamine utilization) genes, which enable the catabolism of ethanolamine (EA) as a valuable source of carbon and/or nitrogen. EA catabolism was previously shown to contribute to the colonization and growth of enteric pathogens, such as Salmonella enterica serovar Typhimurium and enterohemorrhagic Escherichia coli (EHEC), in the gut environment...
May 8, 2018: MBio
https://www.readbyqxmd.com/read/29738037/clinical-and-laboratory-features-of-urinary-tract-infections-in-young-infants
#17
Denise Swei Lo, Larissa Rodrigues, Vera Hermina Kalika Koch, Alfredo Elias Gilio
INTRODUCTION: Urinary tract infection (UTI) is the most common serious bacterial infection in young infants. Signs and symptoms are often nonspecific. OBJECTIVES: To describe clinical, demographic and laboratory features of UTI in infants ≤ 3 months old. METHODS: Cross-sectional study of infants ≤ 3 months old with UTI diagnosed in a pediatric emergency department, for the period 2010-2012. UTI was defined as ≥ 50,000 colony-forming units per milliliter of a single uropathogen isolated from bladder catheterization...
April 26, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29729070/effect-of-the-three-enterococcus-faecalis-strains-on-apoptosis-in-mc3t3-cells
#18
Yang Li, Zhongchun Tong, Junqi Ling
OBJECTIVE: Osteoblast apoptosis is critical for the development and repairing of bone destruction in persistent apical periodontitis (PAP). Enterococcus faecalis is considered as a frequently isolated pathogen of PAP. This study aimed to explore the effect of E. faecalis on apoptosis in osteoblastic MC3T3-E1 cells via an in vitro model. MATERIALS AND METHODS: MC3T3 cells were incubated with live clinically isolated strains of E. faecalis at a multiplicity of infection (MOI) of 1000:1 for 2 h...
May 4, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29726708/antimicrobial-metabolites-from-a-marine-derived-actinomycete-streptomyces-sp-g278
#19
Duc Tuan Cao, Van Hieu Tran, Van Nam Vu, Huong Doan Thi Mai, Thi Hong Minh Le, Thi Quyen Vu, Hung Huy Nguyen, Van Minh Chau, Van Cuong Pham
Analysis of an antimicrobial extract prepared from culture broth of the marine-derived actinomycete Streptomyces sp. G278 led to the isolation of ten compounds, 1-10. Two compounds, 2,5-Bis(5-tert-butyl-2-benzoxazolyl)thiophene (1), and 3-hydroxyl-2-methylpyridine (2) were isolated from a natural source for the first time. The structures of the isolated compounds were established by their spectral data analysis, including mass spectrometry, 1D-NMR, 2D-NMR, and X-ray crystallographic analysis in case of compound 3...
May 4, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29724017/low-maternal-microbiota-sharing-across-gut-breast-milk-and-vagina-as-revealed-by-16s-rrna-gene-and-reduced-metagenomic-sequencing
#20
Ekaterina Avershina, Inga Leena Angell, Melanie Simpson, Ola Storrø, Torbjørn Øien, Roar Johnsen, Knut Rudi
The maternal microbiota plays an important role in infant gut colonization. In this work we have investigated which bacterial species are shared across the breast milk, vaginal and stool microbiotas of 109 women shortly before and after giving birth using 16S rRNA gene sequencing and a novel reduced metagenomic sequencing (RMS) approach in a subgroup of 16 women. All the species predicted by the 16S rRNA gene sequencing were also detected by RMS analysis and there was good correspondence between their relative abundances estimated by both approaches...
May 1, 2018: Genes
keyword
keyword
29440
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"