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Retinal vascular disease

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https://www.readbyqxmd.com/read/28810002/retinal-oximetry-discovers-novel-biomarkers-in-retinal-and-brain-diseases
#1
Einar Stefánsson, Olof Birna Olafsdottir, Anna Bryndis Einarsdottir, Thorunn Scheving Eliasdottir, Thor Eysteinsson, Wouter Vehmeijer, Evelien Vandewalle, Toke Bek, Sveinn Hakon Hardarson
Purpose: Biomarkers for several eye and brain diseases are reviewed, where retinal oximetry may help confirm diagnosis or measure severity of disease. These include diabetic retinopathy, central retinal vein occlusion (CRVO), retinitis pigmentosa, glaucoma, and Alzheimer's disease. Methods: Retinal oximetry is based on spectrophotometric fundus imaging and measures oxygen saturation in retinal arterioles and venules in a noninvasive, quick, safe manner. Retinal oximetry detects changes in oxygen metabolism, including those that result from ischemia or atrophy...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28806613/automatic-blood-vessels-segmentation-based-on-different-retinal-maps-from-octa-scans
#2
Nabila Eladawi, Mohammed Elmogy, Omar Helmy, Ahmed Aboelfetouh, Alaa Riad, Harpal Sandhu, Shlomit Schaal, Ayman El-Baz
The retinal vascular network reflects the health of the retina, which is a useful diagnostic indicator of systemic vascular. Therefore, the segmentation of retinal blood vessels is a powerful method for diagnosing vascular diseases. This paper presents an automatic segmentation system for retinal blood vessels from Optical Coherence Tomography Angiography (OCTA) images. The system segments blood vessels from the superficial and deep retinal maps for normal and diabetic cases. Initially, we reduced the noise and improved the contrast of the OCTA images by using the Generalized Gauss-Markov random field (GGMRF) model...
August 7, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28804464/retinal-vascular-autoregulation-during-phase-iv-of-the-valsalva-maneuver-an-optical-coherence-tomography-angiography-study-in-healthy-chinese-adults
#3
Yuan Zong, Huan Xu, Jian Yu, Chunhui Jiang, Xiangmei Kong, Yi He, Xinghuai Sun
The impairment of retinal vascular autoregulation can be an early manifestation of many systemic and ocular diseases. Therefore, quantifying retinal vascular autoregulation in a non-invasive manner is very important. This study evaluated the effects of a Valsalva maneuver (VM)-induced blood pressure increases on retinal vascular autoregulation. Parafoveal and peripapillary retinal vessel density were measured with optical coherence tomography angiography before (baseline) and 5 s after each subject completed a VM (Phase IV [VM-IV])...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28803548/gestational-hypertensive-disorders-and-retinal-microvasculature-the-generation-r-study
#4
Laura Benschop, Sarah Schalekamp-Timmermans, Jeanine E Roeters van Lennep, Vincent W V Jaddoe, Tien Yin Wong, Carol Y Cheung, Eric A P Steegers, Kamran M Ikram
BACKGROUND: Changes in the microvasculature associated with pre-eclampsia and gestational hypertension have been proposed as a potential pathway in the development of cardiovascular disease. We examined whether gestational hypertensive disorders, such as pre-eclampsia and gestational hypertension, are related to the maternal retinal microvasculature status after pregnancy. METHODS: This study is part of an ongoing population-based prospective cohort study. During pregnancy and 6...
August 14, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28800646/heritability-of-retinal-vascular-fractals-a-twin-study
#5
Anna Stage Vergmann, Rebecca Broe, Line Kessel, Jesper Leth Hougaard, Sören Möller, Kirsten Ohm Kyvik, Michael Larsen, Inger Christine Munch, Jakob Grauslund
Purpose: To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension. Methods: This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50°, disc-centered fundus photographs, the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28791758/agent-based-computational-model-of-retinal-angiogenesis-simulates-microvascular-network-morphology-as-a-function-of-pericyte-coverage
#6
Joseph Walpole, Feilim Mac Gabhann, Shayn M Peirce, John C Chappell
OBJECTIVE: Define a role for perivascular cells during developmental retinal angiogenesis in the context of endothelial cell Notch1-DLL4 signaling at the multicellular network level. METHODS: The retinal vasculature is highly sensitive to growth factor mediated intercellular signaling. Although endothelial cell signaling has been explored in detail, it remains unclear how pericytes function to modulate these signals that lead to a diverse set of vascular network patterns in health and disease...
August 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28791532/diameter-changes-of-retinal-vessels-in-diabetic-retinopathy
#7
REVIEW
Toke Bek
PURPOSE OF REVIEW: The diameter of retinal vessels is an important source of information about retinal blood flow and metabolism. The purpose of the present study is to review how diameter changes of retinal vessels contribute to the development of diabetic retinopathy and may be a marker of the prognosis of the disease. RECENT FINDINGS: The early stages of diabetic retinopathy are accompanied with dilatation of the diameter of retinal vessels and reduced autoregulation...
August 8, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28791067/optical-coherence-tomography-angiography-a-new-tool-in-glaucoma-diagnostics-and-research
#8
Ramin Daneshvar, Kouros Nouri-Mahdavi
Optical coherence tomography angiography (OCTA) is a new modality in ocular imaging which provides high resolution view of the vascular structures in the retina and optic nerve head. This technology has the advantages of being noninvasive, rapid and reproducible. OCTA is becoming a valuable tool for evaluating many retinal and optic nerve diseases. This article provides a brief introduction to the technology and its application in the field of glaucoma diagnostics.
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28790417/impact-of-minocycline-on-vascularization-and-visual-function-in-an-immature-mouse-model-of-ischemic-retinopathy
#9
Wenqin Xu, Jie Yin, Lijuan Sun, Zhicha Hu, Guorui Dou, Zifeng Zhang, Haiyan Wang, Changmei Guo, Yusheng Wang
The role of microglia in the pathophysiology of ischemic retinal diseases has been extensively studied. Retinal microglial activation may be correlated with retinal neovascularization in oxygen-induced retinopathy (OIR), an animal model that has been widely used in retinopathy of prematurity (ROP) research. Minocycline is an antibiotic that decreases microglial activation following hyperoxic and hypoxic-ischemic phases in neonatal rodents. Here, we investigated the effects of minocycline on vascularization and visual function...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28781891/vascular-occlusions-following-ocular-surgical-procedures-a-clinical-observation-of-vascular-complications-after-ocular-surgery
#10
Charlotte Fischer, Anne Bruggemann, Annette Hager, Josep Callizo Planas, Johann Roider, Hans Hoerauf
BACKGROUND: Ocular vascular occlusions following intraocular procedures are a rare complication. We report a case series of patients with retinal vascular occlusions or anterior ischemic optic neuropathy (AION) after anterior and posterior segment surgery and demonstrate possible risk factors. METHODS: Observational case series. RESULTS: In ten patients, vascular occlusions were observed within ten weeks after intraocular surgery: branch retinal arterial occlusion (BRAO) (n = 2), central retinal artery occlusion (CRAO) (n = 2), central retinal vein occlusion (CRVO) (n = 1), branch retinal vein occlusion (BRVO) (n = 1), anterior ischemic optic neuropathy (AION) (n = 3), and combined central artery and vein occlusion (n = 1)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28772065/ultrawide-field-scanning-laser-ophthalmoscopy-imaging-of-lipemia-retinalis
#11
Paolo S Silva, Aditi Gupta, Radwan S Ajlan, Deborah K Schlossman, Ann M Tolson, Jerry D Cavallerano, Lloyd Paul Aiello
OBJECTIVE: To describe the characteristic retinal features of lipemia retinalis when using ultrawide field scanning laser ophthalmoscopy. MAIN POINTS: We report a case series of three subjects with ultrawide field retinal images showing cream discoloration of the fundus, light salmon-coloured posterior retinal vessels and greyish pink peripheral vasculature. On green-only imaging, many of the vessels appear light rather than typically dark. CONCLUSION: Lipemia retinalis is readily apparent on ultrawide field imaging and illustrates the alterations that systemic diseases may induce in the posterior and peripheral retinal vasculature...
August 3, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28771491/atrial-fibrillation-in-retinal-vascular-occlusion-disease-and-non-arteritic-anterior-ischemic-optic-neuropathy
#12
Josep Callizo, Nicolas Feltgen, Antje Ammermann, Janina Ganser, Sebastian Bemme, Thomas Bertelmann, Sebastian Pfeiffer, Andre Duvinage, Klaus Gröschel, Hans Hoerauf, Rolf Wachter
BACKGROUND: Patients with retinal vascular occlusion disease have an increased risk for ischemic stroke and share some risk factors with cerebrovascular disease. The purpose of this study was to analyze the prevalence of atrial fibrillation (AF) in subjects with retinal vascular occlusive disease and anterior ischemic optic neuropathy and to compare these data to an ischemic stroke group. METHODS: Prospective, observational single-center trial. Subjects with retinal artery occlusion (RAO), retinal vein occlusion (RVO) and anterior ischemic optic neuropathy (AION) were included...
2017: PloS One
https://www.readbyqxmd.com/read/28767552/efficacy-and-frequency-of-intravitreal-aflibercept-versus-bevacizumab-for-macular-edema-secondary-to-central-retinal-vein-occlusion
#13
Ayman Lotfy, Kamal A M Solaiman, Ayman Abdelrahman, Ahmed Samir
PURPOSE: To compare the safety, efficacy, and frequency of intravitreal injection of aflibercept and bevacizumab for treatment of macular edema secondary to central retinal vein occlusion. DESIGN: Prospective, comparative, randomized, interventional study. PATIENTS AND METHODS: Eyes with macular edema secondary to central retinal vein occlusion were randomized between two groups according to the intravitreal injection used. Group A included eyes treated with intravitreal aflibercept, and Group B included eyes treated with intravitreal bevacizumab injections...
August 1, 2017: Retina
https://www.readbyqxmd.com/read/28765145/optical-coherence-tomography-angiography-characterisation-of-best-disease-and-associated-choroidal-neovascularisation
#14
Abhilash Guduru, Arushi Gupta, Mudit Tyagi, Subhadra Jalali, Jay Chhablani
AIMS: To characterise the vasculature of the retina in patients with Best vitelliform dystrophy, including those with choroidal neovascularisation (CNV), using optical coherence tomography angiography (OCTA) and correlate with fluorescein angiography (FA). METHODS: This prospective observational study included 19 eyes of 10 patients with Best disease. Using OCTA, all layers of retina were qualitatively characterised for each eye. Patients with CNV also underwent FA, and areas of CNV were measured by OCTA and FA and correlated...
August 1, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28761567/using-an-image-fusion-methodology-to-improve-efficiency-and-traceability-of-posterior-pole-vessel-analysis-by-roptool
#15
Sasapin G Prakalapakorn, Laura A Vickers, Rolando Estrada, Sharon F Freedman, Carlo Tomasi, Sina Farsiu, David K Wallace
BACKGROUND: The diagnosis of plus disease in retinopathy of prematurity (ROP) largely determines the need for treatment; however, this diagnosis is subjective. To make the diagnosis of plus disease more objective, semi-automated computer programs (e.g. ROPtool) have been created to quantify vascular dilation and tortuosity. ROPtool can accurately analyze blood vessels only in images with very good quality, but many still images captured by indirect ophthalmoscopy have insufficient image quality for ROPtool analysis...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28760777/sumoylation-negatively-regulates-angiogenesis-by-targeting-endothelial-notch-signaling
#16
Xiaolong Zhu, Sha Ding, Cong Qiu, Yanna Shi, Lin Song, Yueyue Wang, Yuewen Wang, Jinying Li, Yiran Wang, Yi Sun, Lingfeng Qin, Jun Chen, Michael Simons, Wang Min, Luyang Yu
Rationale: The highly conserved NOTCH signaling pathway functions as a key cell-cell interaction mechanism controlling cell-fate and tissue patterning, while its dysregulation is implicated in a variety of developmental disorders and cancers. The pivotal role of endothelial NOTCH in regulation of angiogenesis is widely appreciated; however, little is known about what controls it signal transduction. Our previous study indicated the potential role of post-translational small ubiquitin-like modifier (SUMO) modification (SUMOylation) in vascular disorders...
July 31, 2017: Circulation Research
https://www.readbyqxmd.com/read/28760677/optical-coherence-tomography-angiography-a-comprehensive-review-of-current-methods-and-clinical-applications
#17
REVIEW
Amir H Kashani, Chieh-Li Chen, Jin K Gahm, Fang Zheng, Grace M Richter, Philip J Rosenfeld, Yonggang Shi, Ruikang K Wang
OCT has revolutionized the practice of ophthalmology over the past 10-20 years. Advances in OCT technology have allowed for the creation of novel OCT-based methods. OCT-Angiography (OCTA) is one such method that has rapidly gained clinical acceptance since it was approved by the FDA in late 2016. OCTA images are based on the variable backscattering of light from the vascular and neurosensory tissue in the retina. Since the intensity and phase of backscattered light from retinal tissue varies based on the intrinsic movement of the tissue (e...
July 28, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28755024/concentration-of-acute-phase-factors-in-vitreous-fluid-in-diabetic-macular-edema
#18
Kazuhiro Kimura, Tomoko Orita, Yuka Kobayashi, Shigeo Matsuyama, Kazushi Fujimoto, Kazuhiko Yamauchi
PURPOSE: Diabetic retinal maculopathy is associated with acute and chronic local inflammation. We measured the concentrations of acute phase factors in vitreous fluid of patients with diabetic macular edema (DME) and examined their relations to visual acuity and central retinal thickness (CRT) both before and after vitrectomy. STUDY DESIGN: Retrospective. METHODS: Vitreous fluid was collected during vitreoretinal surgery from 19 patients with DME and 12 control subjects with epiretinal membrane...
July 28, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28750436/-retinal-vascular-occlusion-modern-therapeutic-approaches
#19
Moritz Pettenkofer, Nicolas Feltgen, Nikolaus Feucht, Chris P Lohmann, Mathias M Maier
Retinal artery occlusion (RAO) should be evaluated as an emergency and can be seen as an ocular analogue to the cerebral apoplex. Both have the same arteriosclerotic risk factors, which are also responsible for cardiac, circulatory and cerebrovascular diseases. That is why an intensive interdisciplinary clarification is necessary to recognize possible comorbidities in time and, if necessary, to treat them. The current therapeutic possibilities of an acute RAO are very limited in their efficiency regarding visual improvement...
July 27, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28746191/whole-exome-sequencing-unveils-a-frameshift-mutation-in-cngb3-for-cone-dystrophy-a-case-report-of-an-indian-family
#20
Shashank Gupta, Amit Chaurasia, Ekta Pathak, Rajeev Mishra, Vidya Nair Chaudhry, Prashaant Chaudhry, Ashim Mukherjee, Mousumi Mutsuddi
RATIONALE: Genetic elucidation of cone-dominated retinal dystrophies in Indian subcontinent is much needed to identify and catalog underlying genetic defects. In this context, the present study recruited a consanguineous Indian family affected with autosomal recessive cone dystrophy (CD). Considering the huge genetic heterogeneity and recessive inheritance of the disease, we chose to dissect out causal variant in this family by whole exome sequencing (WES). PATIENT CONCERNS: In the recruited family, three of the six siblings had complaints of poor visual acuity, photophobia, and disturbed colour vision since early childhood...
July 2017: Medicine (Baltimore)
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