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Retinal vascular disease

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https://www.readbyqxmd.com/read/29165402/quercetin-mitigates-inflammatory-responses-induced-by-vascular-endothelial-growth-factor-in-mouse-retinal-photoreceptor-cells-through-suppression-of-nuclear-factor-kappa-b
#1
Minsup Lee, Seohyeon Yun, Hyesook Lee, Jaewook Yang
Retinal vascular endothelial growth factor (VEGF) increased by neovascularization is well known as a pathogenic factor in ocular neovascular diseases. However, it is still unclear how retinal neurons are damaged by VEGF. The aims of this study are to demonstrate the inflammatory protein expression regulated by VEGF using mouse photoreceptor-derived cells and the protective effect of quercetin against VEGF-induced inflammatory response. Expression and phosphorylation of protein and expression of mRNA were detected by immunoblot and reverse transcriptase polymerase chain reaction...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29160042/hypoxia-challenge-test-and-retinal-circulation-changes-a-study-using-ocular-coherence-tomography-angiography
#2
David Cordeiro Sousa, Inês Leal, Susana Moreira, Patrícia Dionísio, Luís Abegão Pinto, Carlos Marques-Neves
PURPOSE: Previous studies report that the response of retinal vessels to a decrease in oxygen (hypoxia) is vasodilation, thus increasing blood flow. We aimed to characterize the changes in retinal microvasculature induced by a mild hypoxia stress test in a healthy population, using ocular coherence tomography angiography (OCT-A) technology. METHODS: Interventional repeated-measures study. The standardized hypoxia challenge test (HCT) was performed to all volunteers, according to the British Thoracic Society protocol...
November 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29156466/-retinal-artery-occlusions
#3
Gabriele E Lang, Stefan J Lang
Retinal artery occlusions are acute vascular diseases. Very often they are caused by an embolisation. Rarely a thrombosis is caused by an arteriitis. In the acute phase diagnosis in most of the cases can be made by ophthalmoscopy due to the whitish retinal edema and in central retinal artery occlusion the cherry red spot. Difficulties in making the diagnosis can occur in the chronic stage, especially after reperfusion of the retinal vessels, when the fundus colour returned to normal again. Several diagnostic procedures help to make the diagnosis...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29155757/dissection-of-human-retina-and-rpe-choroid-for-proteomic-analysis
#4
Thiago Cabral, Marcus A Toral, Gabriel Velez, James E DiCarlo, Anuradha M Gore, MaryAnn Mahajan, Stephen H Tsang, Alexander G Bassuk, Vinit B Mahajan
The human retina is composed of the sensory neuroretina and the underlying retinal pigmented epithelium (RPE), which is firmly complexed to the vascular choroid layer. Different regions of the retina are anatomically and molecularly distinct, facilitating unique functions and demonstrating differential susceptibility to disease. Proteomic analysis of each of these regions and layers can provide vital insights into the molecular process of many diseases, including Age-Related Macular Degeneration (AMD), diabetes mellitus, and glaucoma...
November 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29150277/the-vegf-paradox-does-diabetic-retinopathy-protect-from-age-related-macular-degeneration
#5
Mario Saravia, Luis Zeman, Mariana Ingolotti, Ariel Schlaen
Age-related macular disease (AMD) and diabetic retinopathy (DR) are prevalent diseases. Vascular endothelial growth factor (VEGF) related retinal neovascularization is a common feature in both. Consequently, both pathologies are treated with anti-VEGF therapy. We have previously reported a lower incidence of AMD in patients with DR compared to controls. The present study hypothesizes that DR in stages in which the concentration of intravitreal VEGF is increased, might have a protective role for both the onset and development of AMD...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29148533/identifying-characteristic-features-of-the-retinal-and-choroidal-vasculature-in-choroideremia-using-optical-coherence-tomography-angiography
#6
A Abbouda, A M Dubis, A R Webster, M Moosajee
PurposeUsing optical coherence tomography angiography (OCTA) to investigate the area with flow in the superficial retinal vessel network (SVRN) and choriocapillaris (CC) layer among male subjects with choroideremia (CHM), female carriers, and normal controls to identify vascular changes.Patients and methodsImages of SRVN and CC layer were acquired in 9 affected males, 5 female carriers, and 14 age- and gender-matched controls using the Angiovue software of the RTVue XR Avanti.ResultsThe mean age was 33 years for affected male CHM patients (median 30 years), 46 years for female carriers (median 53 years), and 39 years for controls (median 38...
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29146905/pericytes-regulate-vegf-induced-endothelial-sprouting-through-vegfr1
#7
Hanna M Eilken, Rodrigo Diéguez-Hurtado, Inga Schmidt, Masanori Nakayama, Hyun-Woo Jeong, Hendrik Arf, Susanne Adams, Napoleone Ferrara, Ralf H Adams
Pericytes adhere to the abluminal surface of endothelial tubules and are required for the formation of stable vascular networks. Defective endothelial cell-pericyte interactions are frequently observed in diseases characterized by compromised vascular integrity such as diabetic retinopathy. Many functional properties of pericytes and their exact role in the regulation of angiogenic blood vessel growth remain elusive. Here we show that pericytes promote endothelial sprouting in the postnatal retinal vasculature...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29146648/economic-evaluation-of-an-e-mental-health-intervention-for-patients-with-retinal-exudative-diseases-who-receive-intraocular-anti-vegf-injections-e-pseye-protocol-for-a-randomised-controlled-trial
#8
Hilde P A van der Aa, Ger H M B van Rens, Frank D Verbraak, Machteld Bosscha, Marc A Koopmanschap, Hannie C Comijs, Pim Cuijpers, Ruth M A van Nispen
INTRODUCTION: Because of the great potential of vascular endothelial growth factor inhibitors (anti-VEGF) for retinal exudative diseases, an increased number of patients receives this treatment. However, during this treatment, patients are subjected to frequent invasive intravitreal injections, and the effects on reversing the process of vision loss are uncertain, which may have negative consequences for patients' mental health. One in three patients experience at least mild symptoms of depression/anxiety...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29137019/optical-coherence-tomography-angiography-in-patients-with-diabetic-retinopathy-treated-with-anti-vegf-intravitreal-injections-case-report
#9
Katarzyna Michalska-Małecka, Anna Heinke Knudsen
PURPOSE: To present optical coherence tomography angiography (OCTA) features in patients with diabetic retinopathy (DR) at the baseline and in response to treatment with anti-VEGF intravitreal injections. To investigate the role of OCTA in management of patients with DR. METHODS: Retrospective case series showing primary outcomes of 3 patients with DR and diabetic macular edema. Patients were injected intravitreally a loading phase of 3 monthly 2.0 mg aflibercept, followed by 2 injections bimonthly (5 injections in total)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135888/exit-strategy-in-a-treat-and-extend-regimen-for-exudative-age-related-macular-degeneration
#10
Petra Arendt, Siqing Yu, Marion R Munk, Andreas Ebneter, Sebastian Wolf, Martin S Zinkernagel
PURPOSE: To evaluate the outcome of an exit strategy in a treat-and-extend regimen for neovascular age-related macular degeneration. METHODS: Five hundred and ninety-eight eyes of 488 patients with neovascular age-related macular degeneration receiving intravitreal anti-vascular endothelial growth factor injections according to a treat-and-extend regimen were included in this retrospective study. A treat-and-extend regimen with either interval extension by 2 weeks or shortening by 1 week was used...
November 9, 2017: Retina
https://www.readbyqxmd.com/read/29135307/correlation-between-flicker-induced-retinal-vessel-vasodilatation-and-plasma-biomarkers-of-endothelial-dysfunction-in-hypertensive-patients
#11
Machalińska Anna, Pius-Sadowska Ewa, Babiak Katarzyna, Sałacka Anna, Safranow Krzysztof, Kawa Miłosz Piotr, Machaliński Bogusław
PURPOSE: Hypertension (HT) strongly affects the vascular endothelium, resulting in chronic inflammatory disease. Dynamic vessel analysis (DVA) is a modern methodological approach to analyze vascular function in the retinal microcirculation. The aim of this study was to examine whether a defective retinal vessels response is associated with HT-induced endothelial dysfunction. MATERIALS AND METHODS: Retinal vessel reactions to flicker stimulation were examined by DVA in both eyes of 37 hypertensive and 41 healthy control subjects...
November 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29134135/polypoidal-choroidal-vasculopathy-on-swept-source-optical-coherence-tomography-angiography-with-variable-interscan-time-analysis
#12
Carl B Rebhun, Eric M Moult, Eduardo A Novais, Carlos Moreira-Neto, Stefan B Ploner, Ricardo N Louzada, ByungKun Lee, Caroline R Baumal, James G Fujimoto, Jay S Duker, Nadia K Waheed, Daniela Ferrara
Purpose: To use a novel optical coherence tomography angiography (OCTA) algorithm termed variable interscan time analysis (VISTA) to evaluate relative blood flow speeds in polypoidal choroidal vasculopathy (PCV). Methods: Prospective cross-sectional study enrolling patients with confirmed diagnosis of PCV. OCTA of the retina and choroid was obtained with a prototype swept-source OCT system. The acquired OCT volumes were centered on the branching vascular network (BVN) and polyps as determined by indocyanine-green angiography (ICGA)...
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29129724/retinal-vasculature-development-in-health-and-disease
#13
REVIEW
Senthil Selvam, Tejas Kumar, Marcus Fruttiger
Development of the retinal vasculature is based on highly coordinated signalling between different cell types of the retina, integrating internal metabolic requirements with external influences such as the supply of oxygen and nutrients. The developing mouse retinal vasculature is a useful model system to study these interactions because it is experimentally accessible for intra ocular injections and genetic manipulations, can be easily imaged and develops in a similar fashion to that of humans. Research using this model has provided insights about general principles of angiogenesis as well as pathologies that affect the developing retinal vasculature...
November 9, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29126840/neuroprotective-effect-of-cannabinoid-receptor-1-antagonist-in-the-mnu-induced-retinal-degeneration-model
#14
Yuanyuan Chen, Xue Luo, Shiliang Liu, Yin Shen
Endocannabinoid system involves in neuroprotective effects on the central neural system. The cannabinoid receptor 1 (CB1R) is widely expressed in the mouse retina. However, the role of cannabinoid receptors in the retina remains unclear. In this work, we established a photoreceptor degeneration mouse model via N-methyl-N-nitrosourea (MNU) administration to identify the neuroprotective effects of cannabinoid receptors. The MNU-induced retinal degeneration behaves similarly to that in the human retinitis pigmentosa (RP)...
November 7, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29124453/a-machine-learning-ensemble-classifier-for-early-prediction-of-diabetic-retinopathy
#15
Somasundaram S K, Alli P
The main complication of diabetes is Diabetic retinopathy (DR), retinal vascular disease and it leads to the blindness. Regular screening for early DR disease detection is considered as an intensive labor and resource oriented task. Therefore, automatic detection of DR diseases is performed only by using the computational technique is the great solution. An automatic method is more reliable to determine the presence of an abnormality in Fundus images (FI) but, the classification process is poorly performed...
November 9, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29121358/optical-coherence-tomography-findings-in-endogenous-fungal-chorioretinitis-retinitis-and-endophthalmitis
#16
John D Stephens, Murtaza K Adam, Bohzo Todorich, Lisa J Faia, Sunir Garg, James P Dunn, Sonia Mehta
BACKGROUND AND OBJECTIVE: To describe spectral-domain optical coherence tomography (SD-OCT) findings in eyes with endogenous fungal chorioretinitis and endophthalmitis. PATIENTS AND METHODS: Retrospective, observational case series of subjects at Wills Eye Hospital and William Beaumont Hospital were identified by screening OCT billing data and cross-referencing with patient charts. Clinical and imaging data were collected for each patient and reviewed. RESULTS: Twelve eyes of seven consecutive patients were identified, demonstrating two patterns of posterior ocular involvement: chorioretinal infiltration and superficial retinal/retinal vascular infiltration without choroidal involvement...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29118394/an-apelin-receptor-antagonist-prevents-pathological-retinal-angiogenesis-with-ischemic-retinopathy-in-mice
#17
Yuki Ishimaru, Fumiya Shibagaki, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda
Pathological retinal angiogenesis is caused by the progression of ischemic retinal diseases and can result in retinal detachment and irreversible blindness. This neovascularization is initiated from the retinal veins and their associated capillaries and involves the overgrowth of vascular endothelial cells. Since expression of the apelin receptor (APJ) is restricted to the veins and proliferative endothelial cells during physiological retinal angiogenesis, in the present study, we investigated the effect of APJ inhibition on pathological retinal angiogenesis in a mouse model of oxygen-induced retinopathy (OIR)...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114842/the-3d-retinal-capillary-circulation-in-pigs-reveals-a-predominant-serial-organization
#18
Stéphane Fouquet, Ophélie Vacca, Florian Sennlaub, Michel Paques
Purpose: To establish a model of the retinal capillary circulation in pigs, which in many aspects is close to the human retina. Methods: Using high density confocal microscopy image stacks of immunolabeled porcine retinal whole mounts, microvessels close to the optic nerve head were traced in three dimensions. The direction of flow of individual capillaries was deduced from their arteriolar and/or venous connections. Results: From major arteries, second-order arteries traversed the nerve fiber layer and resolved exclusively into the superficial vascular plexus (SVP), which dichotomized the blood flow between radial peripapillary capillaries (RPCs) on one side and the intermediate (IVP) and deep vascular plexus (DVP) on the other...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29114091/circulating-endothelial-markers-in-retinal-vasculopathy-with-cerebral-leukoencephalopathy-and-systemic-manifestations
#19
Nadine Pelzer, Roel Bijkerk, Marlies E J Reinders, Anton Jan van Zonneveld, Michel D Ferrari, Arn M J M van den Maagdenberg, Jeroen Eikenboom, Gisela M Terwindt
BACKGROUND AND PURPOSE-: Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a monogenic small vessel disease, caused by C-terminal truncating TREX1 mutations, that can be considered a model for stroke and vascular dementia. The pathophysiology of RVCL-S is largely unknown, but systemic endothelial involvement has been suggested, leading to pathology in the brain and other highly vascularized organs. Here, we investigated circulating endothelial markers to confirm endothelial involvement and identify biomarkers for disease activity...
November 7, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29109897/optic-coherence-angiography-findings-in-type-2-macular-telangiectasia
#20
Hilal Nalcı, Figen Şermet, Sibel Demirel, Emin Özmert
Objectives: To evaluate the vascular changes of idiopathic macular telangiectasia type 2 (MacTel 2) patients with optical coherence tomography angiography (OCTA) and correlate these changes with the findings of spectral domain optical coherence tomography (SD-OCT). Materials and Methods: Simultaneous SD-OCT and OCTA images of 10 eyes of 6 patients who were diagnosed as MacTel 2 in Ankara University Faculty of Medicine, Department of Ophthalmology were obtained and graded according to the OCTA grading system for MacTel 2...
October 2017: Turkish Journal of Ophthalmology
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