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Retinal vascular disease

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https://www.readbyqxmd.com/read/29773842/systemic-vascular-risk-factors-for-multiple-retinal-nerve-fiber-layer-defects
#1
Kyoung In Jung, Seon Joo Kim, Chan Kee Park
Multiple retinal nerve fiber layer (RNFL) defects develop uncommonly, even though glaucomatous RNFL loss is typically observed as one RNFL defect in each quadrant. We investigated the risk factors associated with multiple RNFL defects to increase our understanding of the nature and pathogenesis of various RNFL defect patterns. Data from subjects with multiple RNFL defects (28 patients) and glaucoma patients without multiple RNFL defects (194 patients) were analyzed. The term "multiple RNFL defects" refers to three or more isolated defects separated by a comparatively normal area...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772051/optical-coherence-tomography-angiography-of-pigmented-paravenous-retinochoroidal-atrophy
#2
Maria Vittoria Cicinelli, Chiara Giuffrè, Alessandro Rabiolo, Maurizio Battaglia Parodi, Francesco Bandello
A 58-year-old man with bilateral pigmented paravenous retinochoroidal atrophy (PPRCA) associated with macular coloboma in the right eye underwent color fundus photography and fundus autofluorescence with the California ultra-widefield retinal imaging system (Optos, Dunfermline, UK), spectral-domain optical coherence tomography (SD-OCT) (Heidelberg Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany), and en face OCT angiography (OCTA) (AngioPlex, Cirrus HD-OCT 5000; Carl Zeiss Meditec, Dublin, CA)...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29760969/automated-spectroscopic-retinal-oximetry-with-visible-light-optical-coherence-tomography
#3
Shaohua Pi, Acner Camino, William Cepurna, Xiang Wei, Miao Zhang, David Huang, John Morrison, Yali Jia
Accurate, quantitative assessment of retinal blood oxygen saturation ( sO2 ) may provide a useful early indicator of pathophysiology in several ocular diseases. Here, with visible-light optical coherence tomography (OCT), we demonstrate an automated spectroscopic retinal oximetry algorithm to measure the sO2 within the retinal arteries (A- sO2 ) and veins (V- sO2 ) in rats by automatically detecting the vascular posterior boundary on cross-sectional structural OCT. The algorithm was validated in vitro with flow phantoms and in vivo in rats by comparing the sO2 results, respectively, to those obtained using a blood gas analyzer and pulse oximetry...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29748595/crispr-lbcpf1-prevents-choroidal-neovascularization-in-a-mouse-model-of-age-related-macular-degeneration
#4
Taeyoung Koo, Sung Wook Park, Dong Hyun Jo, Daesik Kim, Jin Hyoung Kim, Hee-Yeon Cho, Jeungeun Kim, Jeong Hun Kim, Jin-Soo Kim
LbCpf1, derived from Lachnospiraceae bacterium ND2006, is a CRISPR RNA-guided endonuclease and holds promise for therapeutic applications. Here we show that LbCpf1 can be used for therapeutic gene editing in a mouse model of age-related macular degeneration (AMD). The intravitreal delivery of LbCpf1, targeted to two angiogenesis-associated genes encoding vascular endothelial growth factor A (Vegfa) and hypoxia inducing factor 1a (Hif1a), using adeno-associated virus, led to efficient gene disruption with no apparent off-target effects in the retina and retinal pigment epithelium (RPE) cells...
May 10, 2018: Nature Communications
https://www.readbyqxmd.com/read/29747351/-how-oct-angiography-will-change-our-daily-practice
#5
X Xu, S Q Yu
Fundus imaging technologies have been developing rapidly in recent years. Among these technologies, the Optical Coherence Tomography Angiography (OCTA) is particularly noteworthy. Unlike traditional angiography, OCTA features non-dye-injection and non-invasivion, and is capable of providing high-resolution 3D images of vascular flow in the retina and choroid in a matter of seconds. Its clinical value is being more and more recognized by retinal specialists. In this article, we will illustrate how OCTA will change our daily practice in four aspects, namely: (1) changing our understanding of the diseases, (2) helping us with differential diagnosis, (3) optimizing clinical service process, (4) redesigning treatment & follow-up process...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29744887/retinal-vascular-segmentation-using-superpixel-based-line-operator-and-its-application-to-vascular-topology-estimation
#6
Tong Na, Jianyang Xie, Yitian Zhao, Yifan Zhao, Yue Liu, Yongtian Wang, Jiang Liu
PURPOSE: Automatic methods of analyzing of retinal vascular networks, such as retinal blood vessel detection, vascular network topology estimation, and arteries / veins classification are of great assistance to the ophthalmologist in terms of diagnosis and treatment of a wide spectrum of diseases. METHODS: We propose a new framework for precisely segmenting retinal vasculatures, constructing retinal vascular network topology, and separating the arteries and veins...
May 9, 2018: Medical Physics
https://www.readbyqxmd.com/read/29744040/recent-advances-in-understanding-and-managing-retinal-vein-occlusions
#7
REVIEW
Daniel D Esmaili, David S Boyer
Retinal vein occlusions are the second most common form of retinal vascular disease. Previously, laser treatment for branch retinal vein occlusion and intravitreal triamcinolone acetonide for central retinal vein occlusion were the standard of care. Recent studies have demonstrated that anti-vascular endothelial growth factor (anti-VEGF) agents have a superior safety and efficacy profile for the treatment of both branch and central retinal vein occlusions. The use of wide-field fluorescein angiography has also allowed better visualization of the retinal periphery...
2018: F1000Research
https://www.readbyqxmd.com/read/29743093/icam-1-related-long-non-coding-rna-promoter-analysis-and-expression-in-human-retinal-endothelial-cells
#8
Amanda L Lumsden, Yuefang Ma, Liam M Ashander, Andrew J Stempel, Damien J Keating, Justine R Smith, Binoy Appukuttan
OBJECTIVE: Regulation of intercellular adhesion molecule (ICAM)-1 in retinal endothelial cells is a promising druggable target for retinal vascular diseases. The ICAM-1-related (ICR) long non-coding RNA stabilizes ICAM-1 transcript, increasing protein expression. However, studies of ICR involvement in disease have been limited as the promoter is uncharacterized. To address this issue, we undertook a comprehensive in silico analysis of the human ICR gene promoter region. RESULTS: We used genomic evolutionary rate profiling to identify a 115 base pair (bp) sequence within 500 bp upstream of the transcription start site of the annotated human ICR gene that was conserved across 25 eutherian genomes...
May 9, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29743025/risk-of-incident-atrial-fibrillation-in-patients-presenting-with-retinal-artery-or-vein-occlusion-a-nationwide-cohort-study
#9
Christine Benn Christiansen, Christian Torp-Pedersen, Jonas Bjerring Olesen, Gunnar Gislason, Morten Lamberts, Nicholas Carlson, Mathias Buron, Nikolai Juul, Gregory Y H Lip
BACKGROUND: The inter-relationships of atrial fibrillation (AF) to retinal vascular occlusions (whether retinal artery occlusion (RAO) or retinal venous occlusion (RVO)) remain unclear. It is unknown if a presentation of retinal artery or venous occlusions may indicate a new onset cardiac arrhythmia. To shed light on this association, we investigated the risk of new onset AF in patients with known RAO and RVO. METHODS: Patients with retinal occlusions from 1997 to 2011 were identified through Danish nationwide registries and matched 1:5 according to sex and age...
May 10, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29740208/early-centripetal-displacements-of-capillaries-in-macular-region-caused-by-internal-limiting-membrane-peeling
#10
Kazuyuki Kumagai, Nobuchika Ogino, Mariko Furukawa, Rieko Ooya, Eiji Horie
Purpose: The aim of this study was to determine whether the centripetal displacement of the capillaries in the macular region after vitrectomy is caused by internal limiting membrane (ILM) peeling. Methods: Eighteen patients with different types of retinal diseases but with a normal or approximately normal foveal contour underwent successful vitrectomy with (n=12) or without (n=6) ILM peeling. Optical coherence tomography angiography (OCTA) images of the inner retinal vascular plexus in the macular region were analyzed pre- and postoperatively...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29721978/vegf-as-a-trophic-factor-for-m%C3%A3-ller-glia-in-hypoxic-retinal-diseases
#11
Shuhua Fu, Shuqian Dong, Meili Zhu, Yun-Zheng Le
Age-related macular degeneration (AMD) and diabetic retinopathy (DR), leading causes of blindness, share a common retinal environment: hypoxia which is a major stimulator for the upregulation of vascular endothelial growth factor (VEGF), a cardinal pathogenic factor for the breakdown of blood-retina barrier (BRB). As a result of intensive studies on VEGF pathobiology, anti-VEGF strategy has become a major therapeutics for wet AMD and DR. To investigate the potential impact of anti-VEGF strategy on major retinal supporting cells, Müller glia (MG), we disrupted VEGF receptor-2 (VEGFR2) in MG with conditional knockout (CKO) and examined the effect of VEGFR2-null on MG viability and neuronal integrity in mice...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29721942/the-role-of-hypoxia-hypoxia-inducible-factor-hif-and-vegf-in-retinal-angiomatous-proliferation
#12
Maya Barben, Marijana Samardzija, Christian Grimm
In industrialized countries, age-related macular degeneration (AMD) is the leading cause of blindness in elderly people. Hallmarks of the non-neovascular (dry) form of AMD are the formation of drusen and geographic atrophy, whereas the exudative (wet) form of the disease is characterized by invading blood vessels. In retinal angiomatous proliferation (RAP), a special form of wet AMD, intraretinal vessels grow from the deep plexus into the subretinal space. Little is known about the mechanisms leading to intraretinal neovascularization, but age-related changes such as reduction of choroidal blood flow, accumulation of drusen, and thickening of the Bruch's membrane may lead to reduced oxygen availability in photoreceptors...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29721940/normative-retinal-thicknesses-in-common-animal-models-of-eye-disease-using-spectral-domain-optical-coherence-tomography
#13
Christy L Carpenter, Alice Y Kim, Amir H Kashani
Purpose This study demonstrates a standardized approach to measuring retinal thickness (RT) using spectral domain optical coherence tomography (SD-OCT) in commonly used animal models of disease and reports a normative data set for future use. Materials and Methods Twenty normal eyes of 4 adult animal models (5 rats, 5 rabbits, 5 canines, and 5 mini-pigs) were used. Manual measurements were made on the commercially available Heidelberg Spectralis™ SD-OCT to determine the total, inner, and outer retinal thickness (RT) at fixed distances from the optic nerve head (ONH) (1, 2, 3, 4, 5, and 6 mm away) in order to control for normal variation in retinal thickness...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29719645/intravitreal-injection-of-anti-vascular-endothelial-growth-factor-agents-for-ocular-vascular-diseases-clinical-practice-guideline
#14
Homayoun Nikkhah, Saeed Karimi, Hamid Ahmadieh, Mohsen Azarmina, Majid Abrishami, Hossein Ahoor, Yousef Alizadeh, Hasan Behboudi, Narsis Daftarian, Mohammad Hossein Dehghan, Morteza Entezari, Fereydoun Farrahi, Heshmatollah Ghanbari, Khalil Ghasemi Falavarjani, Mohammad Ali Javadi, Reza Karkhaneh, Siamak Moradian, Masoud Reza Manaviat, Morsal Mehryar, Ramin Nourinia, Mohammad Mehdi Parvaresh, Alireza Ramezani, Alireza Ragati Haghi, Mohammad Riazi-Esfahani, Masoud Soheilian, Mohsen Shahsavari, Hossein-Ali Shahriari, Zhale Rajavi, Sare Safi, Armin Shirvani, Saeed Rahmani, Hamideh Sabbaghi, Mojgan Pakbin, Bahareh Kheiri, Hossein Ziaei
Purpose: To provide the clinical recommendations for the administration of intravitreal anti-vascular endothelial growth factor (VEGF) drugs especially bavacizumab for ocular vascular diseases including diabetic macular edema, neovascular age-related macular degeneration, myopic choroidal neovascularization, retinal vein occlusion and central serous chorioretinopathy. Methods: Twenty clinical questions were developed by the guideline technical committee. Relevant websites and databases were searched to find out the pertinent clinical practice guidelines to answer the questions...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29716786/systemic-and-ocular-determinants-of-peripapillary-retinal-nerve-fiber-layer-thickness-measurements-in-the-european-eye-epidemiology-e3-population
#15
Matthias M Mauschitz, Pieter W M Bonnemaijer, Kersten Diers, Franziska G Rauscher, Tobias Elze, Christoph Engel, Markus Loeffler, Johanna Maria Colijn, M Arfan Ikram, Johannes R Vingerling, Katie M Williams, Christopher J Hammond, Catherine Creuzot-Garcher, Alain M Bron, Rufino Silva, Sandrina Nunes, Cécile Delcourt, Audrey Cougnard-Grégoire, Frank G Holz, Caroline C W Klaver, Monique M B Breteler, Robert P Finger
PURPOSE: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. DESIGN: Cross-sectional meta-analysis. PARTICIPANTS: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3-82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. METHODS: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis...
April 28, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29710740/a-comparative-study-to-determine-the-optimal-intravitreal-injection-angle-to-the-eye-a-computational-fluid-structure-interaction-model
#16
Alireza Karimi, Reza Razaghi, Hasan Biglari, Hamideh Sabbaghi, Toshihiro Sera, Susumu Kudo
This study was aimed at investigating the role of IVI angle on the induced stresses and deformations among the components of the eye. Thereafter, the most optimal angle of IVI to minimize the complications of post IVI at the injection site on a basis of the computed stresses via a Fluid-Structure Interaction (FSI) computational model was proposed. IntraVitreal Injection (IVI) is broadly employed as a principal treatment of vascular vitro-retinal diseases. So far, there have been reports regarding the complications of post IVI and determine them as severe uveitis, tractional retinal detachment, IntraOcular Pressure (IOP) elevation as well as ocular haemorrhage...
April 20, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29710185/accuracy-and-reliability-of-eye-based-vs-quadrant-based-diagnosis-of-plus-disease-in-retinopathy-of-prematurity
#17
Sang Jin Kim, J Peter Campbell, Jayashree Kalpathy-Cramer, Susan Ostmo, Karyn E Jonas, Dongseok Choi, R V Paul Chan, Michael F Chiang
Importance: Presence of plus disease in retinopathy of prematurity is the most critical element in identifying treatment-requiring disease. However, there is significant variability in plus disease diagnosis. In particular, plus disease has been defined as 2 or more quadrants of vascular abnormality, and it is not clear whether it is more reliably and accurately diagnosed by eye-based assessment of overall retinal appearance or by quadrant-based assessment combining grades of 4 individual quadrants...
April 26, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29705175/ischemic-retinal-vein-occlusion-characterizing-the-more-severe-spectrum-of-retinal-vein-occlusion
#18
REVIEW
Meiaad Khayat, Michael Williams, Noemi Lois
Retinal vein occlusion (RVO), including central (CRVO), branch (BRVO) and hemicentral and hemispheric RVO, is the second most common vascular cause of visual loss, surpassed only by diabetic retinopathy. The presence and extent of retinal ischemia in RVO is associated with a worse prognosis. On this basis, most previously conducted studies considered iRVO and non-iRVO as separate entities based on set thresholds of existing retinal ischemia, as determined by fundus fluorescein angiography (FFA). Other diagnostic technologies have been used specifically in the differentiation of iCRVO and non-iCRVO...
April 26, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29703002/embolic-retinal-and-choroidal-vascular-occlusion-after-peribulbar-triamcinolone-injection-a-case-report
#19
Gang Li, Dongdong Xu, Zhirou Hu, Hui Li
RATIONALE: Retinal and choroidal vascular occlusion is a vision-threatening complication of therapeutic injections in the facial region. The early identification and early treatment are necessary to reduce the risk of harm to the patient. PATIENT CONCERNS: We report an extremely rare case of embolic retinal and choroidal vascular occlusion after peribulbar triamcinolone injection in a patient with thyroid-associated ophthalmopathy. DIAGNOSES: Central retinal artery occlusion...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29701884/retinal-vascular-diameters-in-relation-to-physical-activity-in-danish-children-the-champs-eye-study
#20
Kristian Lundberg, Jakob Tarp, Anders Højslet Vestergaard, Nina Jacobsen, Anne Suhr Thykjaer, Maria Sode Rønne, Anna Bugge, Ernst Goldschmidt, Tunde Peto, Niels Wedderkopp, Jakob Grauslund
Our objective was to determine associations between retinal vascular caliber and physical activity (PA) in a school-based child cohort. In a prospective study we created a childhood cumulative average PA-index using objectively measured PA (accelerometry) assessed at four periods between 2009 and 2015. Cumulative exposure to PA intensities was estimated. Cross-sectional examinations on biomarkers, anthropometry and ophthalmological data including retinal fundus photographs were performed in 2015. Semi-automated measurements of retinal vascular diameters were performed and summarized into central retinal arteriolar and venular equivalents (CRAE, CRVE)...
April 27, 2018: Scandinavian Journal of Medicine & Science in Sports
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