keyword
https://read.qxmd.com/read/38473260/different-periampullary-types-and-subtypes-leading-to-different-perioperative-outcomes-of-pancreatoduodenectomy-reality-and-not-a-myth-an-international-multicenter-cohort-study
#21
JOURNAL ARTICLE
Bas A Uijterwijk, Daniël H Lemmers, Giuseppe Kito Fusai, Bas Groot Koerkamp, Sharnice Koek, Alessandro Zerbi, Ernesto Sparrelid, Ugo Boggi, Misha Luyer, Benedetto Ielpo, Roberto Salvia, Brian K P Goh, Geert Kazemier, Bergthor Björnsson, Mario Serradilla-Martín, Michele Mazzola, Vasileios K Mavroeidis, Santiago Sánchez-Cabús, Patrick Pessaux, Steven White, Adnan Alseidi, Raffaele Dalla Valle, Dimitris Korkolis, Louisa R Bolm, Zahir Soonawalla, Keith J Roberts, Miljana Vladimirov, Alessandro Mazzotta, Jorg Kleeff, Miguel Angel Suarez Muñoz, Marc G Besselink, Mohammed Abu Hilal
This international multicenter cohort study included 30 centers. Patients with duodenal adenocarcinoma (DAC), intestinal-type (AmpIT) and pancreatobiliary-type (AmpPB) ampullary adenocarcinoma, distal cholangiocarcinoma (dCCA), and pancreatic ductal adenocarcinoma (PDAC) were included. The primary outcome was 30-day or in-hospital mortality, and secondary outcomes were major morbidity (Clavien-Dindo 3b≥), clinically relevant post-operative pancreatic fistula (CR-POPF), and length of hospital stay (LOS)...
February 23, 2024: Cancers
https://read.qxmd.com/read/38473035/endoscopic-ultrasound-guided-ablation-of-premalignant-pancreatic-cysts-and-pancreatic-cancer
#22
REVIEW
Alejandra Vargas, Priyata Dutta, Eileen S Carpenter, Jorge D Machicado
Pancreatic cancer is on the rise and expected to become the second leading cause of cancer-related death by 2030. Up to a one-fifth of pancreatic cancers may arise from mucinous pancreatic cysts, which are frequently present in the general population. Currently, surgical resection is the only curative approach for pancreatic cancer and its cystic precursors. However, only a dismal proportion of patients are eligible for surgery. Therefore, novel treatment approaches to treat pancreatic cancer and precancerous pancreatic cysts are needed...
March 6, 2024: Diagnostics
https://read.qxmd.com/read/38472622/early-onset-type-2-diabetes-mellitus-an-update
#23
REVIEW
Myrsini Strati, Melpomeni Moustaki, Theodora Psaltopoulou, Andromachi Vryonidou, Stavroula A Paschou
The incidence and prevalence of type 2 diabetes mellitus (T2DM) in young individuals (aged <40 years) have significantly increased in recent years, approximating two to threefold increase in the respective rates. Numerous risk factors including severe obesity, family history, ethnicity, maternal diabetes or gestational diabetes, and female sex contribute to a younger age of onset. In terms of pathogenesis, impaired insulin secretion is the key operating mechanism, alongside with ectopic adiposity-related insulin resistance...
March 12, 2024: Endocrine
https://read.qxmd.com/read/38472447/ct-based-pancreatic-radiomics-predicts-secondary-loss-of-response-to-infliximab-in-biologically-na%C3%A3-ve-patients-with-crohn-s-disease
#24
JOURNAL ARTICLE
Tian Yang, Jing Feng, Ruchen Yao, Qi Feng, Jun Shen
OBJECTIVES: Predicting secondary loss of response (SLR) to infliximab (IFX) is paramount for tailoring personalized management regimens. Concurrent pancreatic manifestations in patients with Crohn's disease (CD) may correlate with SLR to anti-tumor necrosis factor treatment. This work aimed to evaluate the potential of pancreatic radiomics to predict SLR to IFX in biologic-naive individuals with CD. METHODS: Three models were developed by logistic regression analyses to identify high-risk subgroup prone to SLR...
March 13, 2024: Insights Into Imaging
https://read.qxmd.com/read/38470045/prolactin-effects-on-the-pathogenesis-of-diabetes-mellitus
#25
REVIEW
Roberta Scairati, Renata Simona Auriemma, Guendalina Del Vecchio, Sara Di Meglio, Rosario Pivonello, Annamaria Colao
BACKGROUND: Prolactin (PRL) is a pituitary hormone promoting lactation in response to the suckling reflex. Beyond its well-known effects, novel tissue-specific and metabolic functions of PRL are emerging. AIMS: To dissect PRL as a critical mediator of whole-body gluco-insulinemic sensitivity. METHODS: PubMed-based search with the following terms 'prolactin', 'glucose metabolism', 'type 2 diabetes mellitus', 'type 1 diabetes mellitus', 'gestational diabetes mellitus' was performed...
March 12, 2024: European Journal of Clinical Investigation
https://read.qxmd.com/read/38470018/role-of-%C3%AE-cell-autophagy-in-%C3%AE-cell-physiology-and-the-development-of-diabetes
#26
REVIEW
Xaviera Riani Yasasilka, Myung-Shik Lee
Elucidating the molecular mechanism of autophagy was a landmark in understanding not only the physiology of cells and tissues, but also the pathogenesis of diverse diseases, including diabetes and metabolic disorders. Autophagy of pancreatic β-cells plays a pivotal role in the maintenance of the mass, structure and function of β-cells, whose dysregulation can lead to abnormal metabolic profiles or diabetes. Modulators of autophagy are being developed to improve metabolic profile and β-cell function through the removal of harmful materials and rejuvenation of organelles, such as mitochondria and endoplasmic reticulum...
March 12, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38469606/comparison-of-the-profile-and-management-of-chronic-pancreatitis-between-china-and-western-countries-a-single-center-experience-and-literature-review
#27
JOURNAL ARTICLE
Yu-Yan Zhu, Hong-Ying Li, Ji-Long Fan, Ling-Ling Zhang, De-Qing Jiang, Ji-Chao Huang, Zai-Jun Yu, Qun-Gang Ke, Ye-Ming Wang, Fu-Meng Yang
OBJECTIVE: The etiology, clinical presentation, diagnosis, and treatment strategies of chronic pancreatitis (CP) vary significantly between countries. Specifically, the etiology and surgical approaches to treating CP differ between China and Western countries. Therefore, this study aims to compare the disparities in CP profiles and management based on our single-center experience and recent data from the West. METHODS: From January 2007 to December 2017, a total of 130 consecutive patients with histologically confirmed chronic pancreatitis (CP) underwent surgical treatment at the First Affiliated Hospital of Nanjing Medical University...
2024: Annali Italiani di Chirurgia
https://read.qxmd.com/read/38468990/navigating-nutritional-strategies-a-comprehensive-review-of-early-and-delayed-enteral-feeding-in-acute-pancreatitis
#28
REVIEW
Suprit Malali, Shilpa A Gaidhane, Sourya Acharya, Harshitha Reddy, Nikhil Pantbalekundri
This review critically examines enteral feeding strategies in managing acute pancreatitis, focusing on the contrasting early and delayed initiation approaches. Acute pancreatitis, marked by pancreatic inflammation, poses complex challenges, and nutritional interventions are pivotal in patient outcomes. Early enteral feeding, initiated within 24-48 hours, is associated with positive outcomes such as shortened hospital stays and reduced complications. However, controversies persist, with studies questioning its universal benefits...
February 2024: Curēus
https://read.qxmd.com/read/38468545/a-new-trivalent-recombinant-protein-for-type-2-diabetes-mellitus-with-oral-delivery-potential-design-expression-and-experimental-validation
#29
JOURNAL ARTICLE
Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz
Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly used in clinical practice for the management of type 2 diabetes mellitus. However, the extremely short half-life of GLP-1 and the need for subcutaneous administration limit its clinical application. Thus, half-life extension and alternative delivery methods are highly desired. DARPin domains with high affinity for human serum albumin (HSA) have been selected for the half-life extension of therapeutic peptides and proteins. In the present study, novel trivalent fusion proteins as long-acting GLP-1 receptor agonists with potential for oral delivery were computationally engineered by incorporating a protease-resistant modified GLP-1, an anti-human serum albumin DARPin, and an approved cell-penetrating peptide (Penetratin, Tat, and Polyarginine) linked either by rigid or flexible linkers...
March 11, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38468534/effects-of-mesenchymal-stem-cell-conditioned-media-with-natural-immunomodulatory-agent-resveratrol-on-type-1-diabetes
#30
JOURNAL ARTICLE
Krushna Abhale, Addepalli Veeranjaneyulu, Shivani Desai, Avinash Sanap, Ramesh Bhonde
BACKGROUND: Type 1 diabetes mellitus (T1DM) is a condition marked by elevated blood sugar levels and primarily recognized by the destruction of beta cells caused by an autoimmune attack, which is a significant characteristic of T1DM. Recent studies have demonstrated the regenerative potential of conditioned medium therapy. In light of this, the current research sought to assess the impact of Mesenchymal Stem Cell conditioned media (CM) and CM with resveratrol (CM+ Resveratrol) on the management of T1DM in Swiss albino mice...
March 8, 2024: Current Drug Discovery Technologies
https://read.qxmd.com/read/38467960/the-combination-of-preoperative-celiac-axis-stenting-and-neoadjuvant-chemotherapy-in-an-elderly-patient-with-pancreatic-cancer-a-case-report
#31
JOURNAL ARTICLE
Susumu Doita, Hideki Aoki, Hiroki Kajioka, Kohji Tanakaya, Kenji Kawamoto
BACKGROUND: Celiac axis stenosis (CAS) is frequently observed in patients undergoing pancreaticoduodenectomy (PD). This poses challenges because of the potential disruption of the hepatic arterial blood flow. CASE PRESENTATION: We present the case of an 81-year-old woman diagnosed with pancreatic head cancer and severe CAS caused by calcification. The patient received neoadjuvant chemotherapy (NAC) and underwent preoperative endovascular stenting of the celiac axis to restore blood flow...
March 12, 2024: Surgical Case Reports
https://read.qxmd.com/read/38465073/key-components-of-successful-management-of-acute-fatty-liver-of-pregnancy-a-case-report-and-literature-review
#32
Rekha Patidar, Krishi Gowdra Revannasiddappa, Muniza Ghazanfer
Acute fatty liver of pregnancy (AFLP) is a rare, potentially fatal obstetric emergency. Due to its nonspecific signs and symptoms, there is often a delay in diagnosis and management which is associated with morbid complications and high mortality. We report a case of a 30-year-old female gravida 3 para 2 at 32 weeks gestation who presented with nausea and vomiting for two weeks, pruritis for three days, and upper abdomen pain for a day. A clinical diagnosis of HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome/obstetric cholestasis/AFLP was made...
February 2024: Curēus
https://read.qxmd.com/read/38464586/acute-pancreatitis-secondary-to-moderate-hypertriglyceridemia-a-case-report
#33
Anil Nepali, Satyam Kharga, Malavika Jayan, Prakriti Adhikari, Amit Shah, Vivek Sanker
KEY CLINICAL MESSAGE: It is crucial to remain vigilant about acute pancreatitis, even in cases with moderately elevated triglycerides. Triglycerides as a cause of acute pancreatitis must be considered even in the absence of other risk factors. ABSTRACT: Hypertriglyceridemia is one of the most common causes of acute pancreatitis (AP), with triglyceride levels greater than 1000 mg/dL being an established risk factor for AP. Cases of acute pancreatitis due to triglyceride levels less than 1000 mg/dL have rarely been reported in the literature...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38464365/emerging-and-multifaceted-potential-contributions-of-polyphenols-in-the-management-of-type-2-diabetes-mellitus
#34
REVIEW
Ileana González, Cristian Lindner, Ivan Schneider, Erik Diaz, Miguel Angel Morales, Armando Rojas
Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with a considerable impact on human life, long-term health expenditures, and substantial health losses. In this context, the use of dietary polyphenols to prevent and manage T2DM is widely documented. These dietary compounds exert their beneficial effects through several actions, including the protection of pancreatic islet β-cell, the antioxidant capacities of these molecules, their effects on insulin secretion and actions, the regulation of intestinal microbiota, and their contribution to ameliorate diabetic complications, particularly those of vascular origin...
February 15, 2024: World Journal of Diabetes
https://read.qxmd.com/read/38463521/comprehensive-analysis-based-on-the-disulfidptosis-related-genes-identifies-hub-genes-and-immune-infiltration-for-pancreatic-adenocarcinoma
#35
JOURNAL ARTICLE
Yu Li, Miao-Xuan Chen, Hai-Tao Li, Xiao-Ming Cai, Bo Chen, Ze-Feng Xie
Pancreatic adenocarcinoma (PAAD) is a prevalent and aggressive malignancy in the digestive tract, requiring accurate prediction and effective treatment strategies. Recently, the discovery of disulfidptosis, a novel form of programmed cell death characterized by abnormal disulfide accumulation, has sparked interest in its role in PAAD. In this study, we aimed to investigate the involvement of disulfidptosis-related genes (DRGs) in PAAD. Using publicly available databases, we conducted a comprehensive analysis exploring the complex relationships between DRGs and important aspects of PAAD, including gene expression, immune response, mutation, drug sensitivity, and functional enrichment...
2024: Open Medicine (Warsaw, Poland)
https://read.qxmd.com/read/38463375/early-endoscopic-management-of-an-infected-acute-necrotic-collection-misdiagnosed-as-a-pancreatic-pseudocyst-a-case-report
#36
Hong-Ying Zhang, Chen-Cong He
BACKGROUND: Infected acute necrotic collection (ANC) is a fatal complication of acute pancreatitis with substantial morbidity and mortality. Drainage plays an exceedingly important role as the first step in invasive intervention for infected necrosis; however, there is great controversy about the optimal drainage time, and better treatment should be explored. CASE SUMMARY: We report the case of a 43-year-old man who was admitted to the hospital with severe intake reduction due to early satiety 2 wk after treatment for acute pancreatitis; conservative treatment was ineffective, and a pancreatic pseudocyst was suspected on contrast-enhanced computed tomography (CT)...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38463147/fulminant-emphysematous-pancreatitis-diagnosis-time-counts
#37
Basel Darawsha, Subhi Mansour, Tawfik Fahoum, Naseem Azzam, Yoram Kluger, Ahmad Assalia, Safi Khuri
Emphysematous pancreatitis (EP), a severe form of necrotizing infection of the pancreas, is an extremely rare medical emergency with high rates of mortality. It is characterized by intraparenchymal pancreatic or peri-pancreatic air due to either monomicrobial or polymicrobial infection with gas-forming bacteria or due to entero-pancreatic fistula. EP is classified according to timing from disease onset when air bubble signs were detected on computed tomography (CT) scan, as early onset (within 2 weeks from disease onset) or late (more than 2 weeks from disease onset)...
February 2024: Gastroenterology Research
https://read.qxmd.com/read/38463025/endoscopic-intramural-cystogastrostomy-for-treatment-of-peripancreatic-fluid-collection-a-viewpoint-from-a-surgeon
#38
JOURNAL ARTICLE
Chen-Guo Ker
Percutaneous or endoscopic drainage is the initial choice for the treatment of peripancreatic fluid collection in symptomatic patients. Endoscopic transgastric fenestration (ETGF) was first reported for the management of pancreatic pseudocysts of 20 patients in 2008. From a surgeon's viewpoint, ETGF is a similar procedure to cystogastrostomy in that they both produce a wide outlet orifice for the drainage of fluid and necrotic debris. ETGF can be performed at least 4 wk after the initial onset of acute pancreatitis and it has a high priority over the surgical approach...
February 14, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38460151/multidisciplinary-approach-for-the-management-of-metastatic-poorly-differentiated-neuroendocrine-carcinoma-of-the-pancreas-a-case-report-of-an-exceptional-responder
#39
JOURNAL ARTICLE
Elizabeth S Nakasone, Hannah C Bustillos, Xianyong Gui, Eric Q Konnick, Jonathan G Sham, Stacey A Cohen
Poorly differentiated pancreatic neuroendocrine carcinomas (pNECs) are rare, highly aggressive neoplasms. Frequently metastatic at diagnosis, prognosis is poor with median overall survival estimated to be less than 1 year. Although multidisciplinary management, including systemic medications and locoregional therapies aimed at reducing and preventing symptoms caused by mass effect, is the mainstay of treatment for patients with metastatic well-differentiated pancreatic neuroendocrine tumors, rapid progression, organ dysfunction, and poor performance status often preclude initiation of even single-modality palliative chemotherapy for patients with metastatic pNEC, limiting the use of and recommendation for multidisciplinary management...
March 6, 2024: Pancreas
https://read.qxmd.com/read/38458097/meropenem-versus-piperacillin-tazobactam-for-the-treatment-of-pancreatic-necrosis
#40
JOURNAL ARTICLE
Savannah Racketa, Kelvin Gandhi, Matthew Lambie
PURPOSE: To date, there are three published guidelines discussing management of infected pancreatic necrosis (IPN) with conflicting recommendations. Specifically, The World Society of Emergency Surgery lists piperacillin-tazobactam as a treatment option in addition to meropenem and ciprofloxacin plus metronidazole. Piperacillin-tazobactam may serve as an effective carbapenem-sparing alternative. Although previous studies shed light on antimicrobial penetration data, there is a lack of clinical data comparing piperacillin-tazobactam to meropenem...
February 10, 2024: Diagnostic Microbiology and Infectious Disease
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