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Management of pancreatitis

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https://www.readbyqxmd.com/read/29452860/pancreaticoduodenectomy-in-the-surgical-management-of-primary-retroperitoneal-sarcoma
#1
William W Tseng, Denice D Tsao-Wei, Dario Callegaro, Giovanni Grignani, Lorenzo D'Ambrosio, Sylvie Bonvalot, Cecilia G Ethun, Kenneth Cardona, John T Mullen, Robert J Canter, John E Mullinax, Ricardo J Gonzalez, Frits van Coevorden, Markus Albertsmeier, Kiran K Dhanireddy, Salvatore L Renne, Alessandro Gronchi
BACKGROUND: In retroperitoneal sarcoma (RPS), the optimal extent of resection must balance adequate disease control with potential for morbidity. We sought to study the frequency and outcomes after a Whipple procedure or pancreaticoduodenectomy (PD) in patients undergoing resection for primary RPS. METHODS: Participating referral centers within the Trans-Atlantic Retroperitoneal Sarcoma Working Group provided retrospective data from January 2007 to December 2016 for patients with primary RPS who underwent PD along with the total number of consecutive resections done during the same time period...
February 5, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29451166/molecular-analysis-of-pancreatic-cyst-fluid-changes-clinical-management
#2
David M Arner, Brooke E Corning, Ali M Ahmed, Henry C Ho, Bradley J Weinbaum, Uzma Siddiqui, Harry Aslanian, Reid B Adams, Todd W Bauer, Andrew Y Wang, Vanessa M Shami, Bryan G Sauer
Background and Objectives: DNA molecular analysis has been suggested as a tool to evaluate pancreatic cysts. This study assesses whether the addition of DNA molecular analysis alters clinical management. Methods: This is a retrospective review of 46 consecutive patients who underwent EUS-FNA of pancreatic cysts with DNA molecular analysis at two major academic institutions. Cases were presented to two pancreaticobiliary surgeons first without and then with DNA molecular analysis data...
January 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29445028/evaluation-of-treatment-patterns-and-survival-outcomes-in-elderly-pancreatic-cancer-patients-a-surveillance-epidemiology-and-end-results-medicare-analysis
#3
Walid L Shaib, Jeb S Jones, Michael Goodman, Juan M Sarmiento, Shishir K Maithel, Kenneth Cardona, Sujata Kane, Christina Wu, Olatunji B Alese, Bassel F El-Rayes
BACKGROUND: Management of pancreatic cancer (PC) in elderly patients is unknown; clinical trials exclude patients with comorbidities and those of extreme age. This study evaluated treatment patterns and survival outcomes in elderly PC patients using linked Surveillance, Epidemiology, and End Results (SEER) and Medicare data. MATERIALS AND METHODS: Histology codes 8140, 8500, 8010, 8560, 8490, 8000, 8260, 8255, 8261, 8263, 8020, 8050, 8141, 8144, 8210, 8211, or 8262 in Medicare Parts A and B were identified...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29443736/what-may-cause-fetus-loss-from-acute-pancreatitis-in-pregnancy-analysis-of-54-cases
#4
Min Tang, Jian-Ming Xu, Sha-Sha Song, Qiao Mei, Li-Jiu Zhang
Acute pancreatitis in pregnancy (APIP) poses a serious threat to the mother and her fetus, and might lead to fetal loss including miscarriage and stillbirth in certain patients. We sought to identify possible factors that affect fetal distress and evaluated outcomes of patients with APIP.We retrospectively reviewed clinical records of 54 pregnant women with APIP, who were treated at 2 tertiary clinical centers over a 6-year period. Clinical characteristics including etiology and severity of APIP, fetal monitoring data, and maternofetal outcomes were analyzed...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442238/two-point-measurement-of-amylase-in-drainage-fluid-predicts-severe-postoperative-pancreatic-fistula-after-gastric-cancer-surgery
#5
Satoshi Kamiya, Naoki Hiki, Koshi Kumagai, Michitaka Honda, Souya Nunobe, Manabu Ohashi, Takeshi Sano, Toshiharu Yamaguchi
BACKGROUND: Early identification of patients at risk of postoperative pancreatic fistula (POPF) allows appropriate management after gastrectomy. Although some reports have suggested a correlation between POPF and the concentration of amylase in drained abdominal fluid (D-AMY), this has not been proven to impact sufficiently on clinical decision-making. A sustained high level of D-AMY is often assumed to be due to unsatisfactory drainage or excessive pancreatic leakage. We assessed the clinical utility of measuring D-AMY on postoperative day (POD) 1 and POD3 for prediction of POPF...
February 13, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29441227/pancreaticoportal-fistula-formation-as-a-consequence-of-recurrent-acute-pancreatitis-clinical-and-imaging-considerations
#6
Mina S Makary, Edward L Gayou, Douglas Kyrouac, Zarine K Shah
A pancreatic-portal vein fistula (PPVF) is an extremely rare complication of pancreatitis. In this report, we present a patient with a PPVF in the setting of recurrent pancreatitis and portal vein thrombosis diagnosed by cross-sectional imaging and endoscopic retrograde cholangio-pancreatography, who responded to medical management and anticoagulation. A critical review of this disease process is explored to highlight pathology, imaging characteristics, and essential alternative diagnostic considerations. We also discuss potential complications and current treatment strategies...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29439301/safe-and-effective-triglyceride-lowering-therapy-for-hypertriglyceridemia-associated-pancreatitis-insulin-mono-therapy-in-a-non-diabetic-patient
#7
Chencheng Xie, Dennis C Stevens, Tamera Sturm
This report was prepared to describe a case in which insulin monotherapy was efficacious for the management of hypertriglyceridemia-associated pancreatitis (HGTP) in a patient who was not diabetic. Currently, there are no definite clinical guidelines or standards of practice for nondiabetic HGTP. Apart from insulin infusion, other regimens include plasmapheresis and heparin administration, both of which carry significant risks. We reported a case of a non-diabetic male with HTGP (triglyceride greater than 3,000 mg/dL) who was successfully managed with an insulin infusion...
January 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29434073/placental-growth-factor-plgf-is-linked-to-inflammation-and-metabolic-disorders-in-mice-with-diet-induced-obesity
#8
Mincheol Kang, Jain Jeong, Jinhee Lee, Song Park, Yonghun Sung, Minjee Choi, Wookbong Kwon, Soyoung Jang, Kwang Shik Choi, Yeon Sik Choo, Duhak Yoon, Myoung Ok Kim, Zae Young Ryoo
Placental growth factor (PlGF), a member of the vascular endothelial growth factor (VEGF) sub-family, plays a major role in angiogenesis and vasculogenesis. Previous study demonstrated that PlGF-overexpressing transgenic (Tg) mice had gestational loss. In addition, PlGF secretion was up-regulated in isolated T lymphocytes (T-cell) upon CD3/CD28 stimulation, suggesting that PlGF could be a regulator of T-cell differentiation and development. T-cells are well known to play a critical role in obesity-induced inflammation...
February 9, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29433859/effect-of-endoscopic-failure-on-the-results-of-internal-surgical-drainage-in-pancreatic-pseudocyst
#9
Fabien Robin, Manuela Cesaretti, Michel Rayar, Christophe Laurent, Nicolas Regenet, Bernard Meunier, Alain Sauvanet, Laurent Sulpice
BACKGROUND: The treatment of pancreatic pseudocysts has evolved during the past two decades. Endoscopic treatment (ET) has gradually become used as a first-line management even though it showed no significant superiority to surgical internal drainages (SIDs) in a recent randomized trial. The objective of the present work was to analyze the effect of ET failure on the results of SID in the global management of pancreatic pseudocysts. METHODS: A multicenter retrospective study (Clichy, Bordeaux, Nantes, and Rennes) was conducted between January 2000 and December 2012...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433670/genistein-induced-anticancer-effects-on-pancreatic-cancer-cell-lines-involves-mitochondrial-apoptosis-g-0-g-1-cell-cycle-arrest-and-regulation-of-stat3-signalling-pathway
#10
Yi-Liang Bi, Min Min, Wei Shen, Yan Liu
BACKGROUND: Genistein is a natural flavonoid that has been reported to exhibit anticancer effects against different types of cancers which include, but are not limited to, breast and oral squamous cell carcinoma. PURPOSE: The present study was designed to evaluate the anticancer effects of the natural flavonoid genistein against pancreatic cancer cell lines and to explore the underlying mechanism. METHODS: Antiproliferative activity was investigated by MTT assay...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29430229/pancreatic-pseudocyst-ruptured-due-to-acute-intracystic-hemorrhage
#11
Kunishige Okamura, Masanori Ohara, Tsukasa Kaneko, Tomohide Shirosaki, Aki Fujiwara, Takumi Yamabuki, Ryo Takahashi, Kazuteru Komuro, Nozomu Iwashiro, Noriko Kimura
Rupture of pancreatic pseudocyst is one of the rare complications and usually results in high mortality. The present case was a rupture of pancreatic pseudocyst that could be treated by surgical intervention. A 74-year-old man developed abdominal pain, vomiting, and diarrhea, and he was diagnosed with cholecystitis and pneumonia. Three days later, acute pancreatitis occurred and computed tomography (CT) showed slight hemorrhage in the cyst of the pancreatic tail. After another 10 days, CT showed pancreatic cyst ruptured due to intracystic hemorrhage...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29421807/the-clinical-management-of-main-duct-intraductal-papillary-mucinous-neoplasm-of-the-pancreas
#12
Chiara Dal Borgo, Giampaolo Perri, Alex Borin, Giovanni Marchegiani, Roberto Salvia, Claudio Bassi
BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas comprise a heterogeneous group of intraductal mucin-producing neoplasms representing a typical adenoma-to-carcinoma sequence. The involvement of the main pancreatic duct (MPD) is a feature of paramount importance, directly related to a more aggressive biology and a higher malignancy rate. METHOD: We review and discuss the clinical management of IPMNs with a MPD involvement, recalling the different consensus guidelines and addressing recent controversies in literature, presenting the current clinical practice in Verona Pancreas Institute...
February 8, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29416715/long-term-follow-up-and-novel-splice-donor-mutation-in-men1-in-a-chinese-family
#13
Minghao Li, Qianqian Liu, Peihua Liu, Xiaoping Yi, Xiao Guan, Anze Yu, Longfei Liu, Feizhou Zhu
Heterozygous germline mutation of the MEN1 tumor suppressor gene is responsible for multiple endocrine neoplasia type 1. Parathyroid and thoracic neuroendocrine tumor specimens and DNA from two Han Chinese MEN1 family patients were analyzed using whole exome and Sanger sequencing. The proband (II-3) was sequentially diagnosed with pituitary adenoma, pancreatic tumor, adrenal cortical tumor, abdominal lipoma, and parathyroid adenoma during the 6-year follow-up. The son of the proband (III-6) was also diagnosed with a thoracic neuroendocrine tumor and a parathyroid adenoma during this period...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414775/the-maz-transcription-factor-is-a-downstream-target-of-the-oncoprotein-cyr61-ccn1-and-promotes-pancreatic-cancer-cell-invasion-via-craf-erk-signaling
#14
Gargi Maity, Inamul Haque, Arnab Ghosh, Gopal Dhar, Vijayalaxmi G Gupta, Sandipto Sarkar, Imaan Azeem, Douglas McGregor, Abhishek Choudhary, Donald R Campbell, Suman Kambhampati, Sushanta K Banerjee, Snigdha Banerjee
Myc-associated zinc-finger protein (MAZ) is a transcription factor with dual roles in transcription initiation and termination. Deregulation of MAZ expression is associated with the progression of pancreatic ductal adenocarcinoma (PDAC). However, the mechanism of action of MAZ in PDAC progression is largely unknown. Here, we present evidence that MAZ mRNA expression and protein levels are increased in human PDAC cell lines, tissue samples, a subcutaneous tumor xenograft in a nude mouse model, and spontaneous cancer in the genetically engineered PDAC mouse model...
February 6, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29414301/palmatine-suppresses-glutamine-mediated-interaction-between-pancreatic-cancer-and-stellate-cells-through-simultaneous-inhibition-of-survivin-and-col1a1
#15
Divya Chakravarthy, Amanda R Muñoz, Angel Su, Rosa F Hwang, Brian R Keppler, Daniel E Chan, Glenn Halff, Rita Ghosh, Addanki P Kumar
Reciprocal interaction between pancreatic stellate cells (PSCs) and cancer cells (PCCs) in the tumor microenvironment (TME) promotes tumor cell survival and progression to lethal, therapeutically resistant pancreatic cancer. The goal of this study was to test the ability of Palmatine (PMT) to disrupt this reciprocal interaction in vitro and examine the underlying mechanism of interaction. We show that PSCs secrete glutamine into the extracellular environment under nutrient deprivation. PMT suppresses glutamine-mediated changes in GLI signaling in PCCs resulting in the inhibition of growth and migration while inducing apoptosis by inhibition of survivin...
January 31, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29413719/role-of-ulinastatin-a-trypsin-inhibitor-in-severe-acute-pancreatitis-in-critical-care-setting-a-retrospective-analysis
#16
Jui Yeshavant Lagoo, Moses Charles D'Souza, Anandajith Kartha, Appanervanda Muthanna Kutappa
PURPOSE: To evaluate the clinical utility of Ulinastatin, a multifunctional serine protease inhibitor, in the management of severe acute pancreatitis. MATERIALS AND METHODS: We conducted a retrospective analysis of the archived data of adult patients diagnosed with acute pancreatitis and admitted to surgical intensive care unit with one or more end organ dysfunction. The patients were divided into two groups depending on whether they did or did not receive ulinastatin...
January 25, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29412391/more-than-kin-less-than-kind-one-family-and-the-many-faces-of-diabetes-in-youth
#17
Luciana F Franco, Renata Peixoto-Barbosa, Renata P Dotto, José Gilberto H Vieira, Magnus R Dias-da-Silva, Luiz Carlos F Reis, Fernando M A Giuffrida, Andre F Reis
Identification of the correct etiology of diabetes brings important implications for clinical management. In this report, we describe a case of a 4-year old asymptomatic girl with diabetes since age 2, along with several individuals in her family with different etiologies for hyperglycemia identified in youth. Genetic analyses were made by Sanger sequencing, laboratory measurements included HbA1c, lipid profile, fasting C-peptide, pancreatic auto-antibodies (glutamic acid decarboxylase [GAD], Islet Antigen 2 [IA-2], and anti-insulin)...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412232/laparoscopic-versus-open-pylorus-preserving-pancreatoduodenectomy-the-first-meta-analyse-of-retrospective-matched-cases
#18
Liwei Pang, Jing Kong, Yuwen Wang, Yan Zhang
PURPOSE: To compare the safety, feasibility, and short-term clinical benefits of laparoscopic pylorus-preserving pancreaticoduodenectomy (L-PPPD) to open pylorus-preserving pancreaticoduodenectomy (O-PPPD) through retrospective matched cases. METHODS: Web of Science, Cochrane, PubMed, CNKI were searched systematically identify studies published between January and December 2017 comparing L-PPPD to O-PPPD. The meta-analysis was performed by using Review Manager 5...
January 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29409791/minimally-invasive-surgery-in-the-era-of-step-up-approach-for-treatment-of-severe-acute-pancreatitis
#19
Olga Morató, Ignasi Poves, Lucas Ilzarbe, Aleksandar Radosevic, Antonia Vázquez-Sánchez, Juan Sánchez-Parrilla, Fernando Burdío, Luís Grande
OBJECTIVES: To assess the minimally invasive surgery into the step-up approach procedures as a standard treatment for severe acute pancreatitis and comparing its results with those obtained by classical management. METHODS: Retrospective cohort study comparative with two groups treated over two consecutive, equal periods of time were defined: group A, classic management with open necrosectomy from January 2006 to June 2010; and group B, management with the step-up approach with minimally invasive surgery from July 2010 to December 2014...
January 30, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29409760/american-gastroenterological-association-institute-guideline-on%C3%A2-initial-management-of-acute-pancreatitis
#20
Seth D Crockett, Sachin Wani, Timothy B Gardner, Yngve Falck-Ytter, Alan Barkun
No abstract text is available yet for this article.
February 3, 2018: Gastroenterology
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