Gabriel Casagrande Zabot, Eduarda Behenck Medeiros, Bárbara Machado Naspolini Macarini, Bruno Búrigo Peruchi, Gabriela Serafim Keller, Adrielly Vargas Lídio, Amanda Boaventura, Laura Ceolin de Jesus, Gustavo de Bem Silveira, Paulo Cesar Lock Silveira, Beatriz Costa Chede, Gislaine Zilli Réus, Josiane Budni
Alzheimer's disease (AD) and depression are inflammatory pathologies leading to increased inflammatory response and neurotoxicity. Therefore, this study aimed to evaluate the effect of the treatment with fluoxetine and/or galantamine and/or donepezil on the levels of proinflammatory and anti-inflammatory cytokines in a mixed animal model of depression and dementia. Adult male Wistar rats underwent chronic mild stress (CMS) protocol for 40 days were subjected to stereotaxic surgery for intra-hippocampal administration of amyloid-beta (Aꞵ) peptide or artificial cerebrospinal fluid (ACSF) to mimic the dementia animal model...
March 27, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry