keyword
MENU ▼
Read by QxMD icon Read
search

fluoxetine

keyword
https://www.readbyqxmd.com/read/29054049/individual-variability-in-clinical-effect-and-tolerability-of-opioid-analgesics-importance-of-drug-interactions-and-pharmacogenetics
#1
REVIEW
Vigdis Solhaug, Espen Molden
BACKGROUND: As pain is often a comorbid condition, many patients use opioid analgesics in combination with several other drugs. This implies a generally increased risk of drug interactions, which along with inherent pharmacogenetic variability and other factors may cause differences in therapeutic response of opioids. AIM: To provide an overview of interactions and pharmacogenetic variability of relevance for individual differences in effect and tolerability of opioid analgesics, which physicians and other healthcare professionals should be aware of in clinical practice...
October 17, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29053927/safety-of-pharmacotherapy-options-for-bulimia-nervosa-and-binge-eating-disorder
#2
Nicholas T Bello, Bryn L Yeomans
Eating disorders represent a set of psychiatric illnesses with lifelong complications and high relapse rates. Individuals with eating disorders are often stigmatized and clinicians have a limited set of treatments options. Pharmacotherapy has the potential to improve long term compliance and patient commitment to treatment for eating disorders. Areas Covered: This review will examine the efficacy and safety profile of the FDA-approved medications for the treatment of bulimia nervosa (BN) and binge eating disorder (BED)...
October 20, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29053139/chronic-fluoxetine-upregulates-activity-protein-and-mrna-levels-of-cytosolic-phospholipase-a2-in-rat-frontal-cortex
#3
J S Rao, R N Ertley, H-J Lee, S I Rapoport, R P Bazinet
This corrects the article DOI: 10.1038/sj.tpj.6500391.
October 17, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29050222/beneficial-effect-of-fluoxetine-treatment-aganist-psychological-stress-is-mediated-by-increasing-bdnf-expression-in-selected-brain-areas
#4
Gongying Li, Ping Jing, Zhidong Liu, Zhiruo Li, Hongxia Ma, Wenzhen Tu, Wei Zhang, Chuanjun Zhuo
SSRI antidepressant fluoxetine is widely used to treat psychological stress related disorders, however the underlying working mechanisms is not fully understood, as SSRIs can rapidly increase the extracellular serotonin levels but it normally takes weeks to reveal their therapeutic effect in the stress-related psychological disorders. Our previous study demonstrated that purely psychological stress without any physic stimuli induces a biphasic change in the expression of brain-derived neurotrophic factor (BDNF), which immediately decrease and then gradually increase after the stress; and that the latter BDNF increase in response to the psychological stress involves the activation of serotonin system...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049533/association-of-antidepressant-medications-with-incident-type-2-diabetes-among-medicaid-insured-youths
#5
Mehmet Burcu, Julie M Zito, Daniel J Safer, Laurence S Magder, Susan dosReis, Fadia T Shaya, Geoffrey L Rosenthal
Importance: Antidepressants are one of the most commonly prescribed classes of psychotropic medications among US youths. For adults, there is emerging evidence on the increased risk of type 2 diabetes in association with antidepressant use. However, little is known about the antidepressant treatment-emergent risk of type 2 diabetes among youths. Objective: To assess the association between antidepressant use and the risk of incident type 2 diabetes in youths by antidepressant subclass and according to duration of use, cumulative dose, and average daily dose...
October 16, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29049348/chronic-administration-of-fluoxetine-and-pro-inflammatory-cytokine-change-in-a-rat-model-of-depression
#6
Yanxia Lu, Cyrus S Ho, Xin Liu, Anna N Chua, Wei Wang, Roger S McIntyre, Roger C Ho
This study evaluated the chronic effects of fluoxetine, a commonly prescribed SSRI antidepressant, on the peripheral and central levels of inflammatory cytokines including IL-1β, IL-6, TNF-α and IL-17 over a 4-interval in a rat model of chronic mild stress (CMS) which resembles the human experience of depression. Twenty-four Sprague-Dawley rats were randomly assigned to CMS+vehicle (n = 9), CMS+fluoxetine (n = 9) and the control (n = 6) groups. Sucrose preference and forced swim tests were performed to assess behavioral change...
2017: PloS One
https://www.readbyqxmd.com/read/29044198/transgenic-mice-lacking-creb-and-crem-in-noradrenergic-and-serotonergic-neurons-respond-differently-to-common-antidepressants-on-tail-suspension-test
#7
Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Justyna Kuśmierczyk, Rosanna Parlato, Irena Nalepa
Evidence exists that chronic antidepressant therapy enhances CREB levels and activity. Nevertheless, the data are not conclusive, as previous analysis of transgenic mouse models has suggested that CREB inactivation in fact contributes to antidepressant-like behavior. The aim of this study was to evaluate the role of CREB in this context by exploiting novel transgenic mouse models, characterized by selective ablation of CREB restricted to noradrenergic (Creb1(DBHCre)/Crem-/-) or serotonergic (Creb1(TPH2CreERT2)/Crem-/-) neurons in a CREM-deficient background to avoid possible compensatory effects of CREM...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044007/depressive-symptoms-monoamines-levels-mao-b-activity-and-effect-of-treatment-in-a-subset-of-depressed-individuals-from-government-sector-hospital-at-karachi
#8
Farah Zeb, Sabira Naqvi, Razaur Rahman, Ahsana Dar Farooq
Depression is one of the leading causes of disability in developing countries including Pakistan. This study was designed to assess the frequency and severity of depressive symptoms, monoamines and their metabolite levels, MAO-B activities before and after treatment with antidepressants in a sub-set of Karachi population in Pakistan. Drug naive depressed subjects were evaluated before and after treatment with selective serotonin reuptake inhibitors. Symptoms of depressed mood and anxiety psychic (90%) were more frequent whereas, suicidal thoughts (~50%) and feelings of guilt (~30%) were less common...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29042992/timosaponin-b-iii-exhibits-antidepressive-activity-in-a-mouse-model-of-postpartum-depression-by-the-regulation-of-inflammatory-cytokines-bndf-signaling-and-synaptic-plasticity
#9
Xiao-Li Zhang, Lin Wang, Li Xiong, Feng-Hua Huang, Han Xue
The aim of this study was to investigate the antidepressive effects of timosaponin B-III (TB-III) and the underlying mechanism. A postpartum depression (PPD) mouse model was established by the administration of dexamethasone sodium phosphate during pregnancy. Mice with PPD were assigned to the following groups: Model, fluoxetine and high, medium and low doses of TB-III. Post-parturient mice without PPD served as a normal control group. To examine the effect of TB-III, mice were treated with TB-III, then forced swimming tests (FSTs) and tail suspension tests (TSTs) were performed to evaluate depression...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042890/effects-of-psychotropic-drugs-on-seizure-threshold-during-electroconvulsive-therapy
#10
Su-Hyuk Chi, Hyun-Ghang Jeong, Suji Lee, So-Young Oh, Seung-Hyun Kim
OBJECTIVE: To analyze the relationship between seizure threshold (ST) and psychotropic drugs in patients treated with ECT. METHODS: We examined clinical data from 43 patients. ST was titrated at each treatment session. We examined associations between ST and psychotropic drugs using multivariate correlation analyses. Data are presented as initial ST, the difference in ST between the first and 10th sessions (ΔST10th), and the mean difference in ST between the first and last sessions (mean ΔSTlast)...
September 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29042260/pldt-planarian-light-dark-test-an-invertebrate-assay-to-quantify-defensive-responding-and-study-anxiety-like-effects
#11
Ashenafi Mebratu Zewde, Frances Yu, Sunil Nayak, Christopher Tallarida, Allen B Reitz, Lynn G Kirby, Scott M Rawls
BACKGROUND: Planarians, like rodents, instinctively spend more time in dark versus light environments when given a choice. This behavioral phenomenon is called negative phototaxis, which may reflect defensive responding related to an anxiety-like phenotype. NEW METHOD: We propose a planarian light/dark test, designated PLDT, to predict anxiogenic- or anxiolytic-like effects. Experimentally, we placed a planarian at the midline of a Petri dish, containing test compound or water, that was split evenly into light and dark compartments and determined time spent in the light over 10min...
October 14, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29042248/the-antidepressant-and-anxiolytic-like-effects-of-fluoxetine-and-clozapine-in-chronically-isolated-rats-involve-inhibition-of-hippocampal-tnf-%C3%AE
#12
Nevena Todorović, Dragana Filipović
Brain oxidative stress and neuroinflammation are implicated in psychiatric disorders. Thus, it is important to investigate the effects of individual psychotropic agents on antioxidative defense and proinflammatory mediators in brain regions associated with these disorders. Psychosocial stress is recognized as a threat to mental health, and the hippocampus is a primary target of stress-related damage. Chronic social isolation (CSIS) is a mild psychosocial stress used to model the pathophysiology of depression...
October 14, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29040085/sources-of-pharmaceuticals-and-personal-care-products-in-swimming-pools
#13
Laura M Suppes, Ching-Hua Huang, Wan-Ning Lee, Kyle J Brockman
Pharmaceuticals and personal care products (PPCPs) in swimming pool water are hypothesized to originate from fill water and anthropogenic sources like urine, sweat, swimwear and body surfaces. However, research exploring PPCP origins in pools is lacking. This research investigates PPCP sources at 31 swimming pools. Pool water was analyzed for 24 representative PPCPs using advanced liquid chromatography-mass spectrometry techniques. Fill water was analyzed as a contamination source and to determine if swimmers introduce PPCPs to pools...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29034205/kaempferia-parviflora-rhizome-extract-and-myristica-fragrans-volatile-oil-increase-the-levels-of-monoamine-neurotransmitters-and-impact-the-proteomic-profiles-in-the-rat-hippocampus-mechanistic-insights-into-their-neuroprotective-effects
#14
Waluga Plaingam, Siriporn Sangsuthum, Wannee Angkhasirisap, Tewin Tencomnao
Potentially useful in the treatment of neurodegenerative disorders, Kaempferia parviflora and Myristica fragrans have been shown to possess a wide spectrum of neuropharmacological activities and neuroprotective effects in vivo and in vitro. In this study, we determined whether and how K. parviflora ethanolic extract and M. fragrans volatile oil could influence the levels of neurotransmitters and the whole proteomic profile in the hippocampus of Sprague Dawley (SD) rats. The effects of K. parviflora and M...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033482/in-vitro-antioxidant-and-in-vivo-antidepressant-activity-of-green-synthesized-azomethine-derivatives-of-cinnamaldehyde
#15
Sridevi Chigurupati, Sohrab Akhtar Shaikh, Jahidul Islam Mohammad, Kesavanarayanan Krishnan Selvarajan, Appala Raju Nemala, Chu How Khaw, Chun Foo Teoh, Ting Hei Kee
OBJECTIVES: In this study, three (CS-1 to CS-3) azomethine derivatives of cinnamaldehyde were green synthesized, characterized, and their antioxidant and antidepressant activities were explored. MATERIALS AND METHODS: The antioxidant effect of these compounds was initially performed in vitro using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay methods before subjecting them to in vivo experiments. Compounds showing potent antioxidant activity (CS-1 and CS-2) were investigated further for their antidepressant activity using the forced swim test (FST) and tail suspension test (TST)...
May 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29033248/use-of-oral-antidepressants-in-patients-with-chronic-pruritus-a-systematic-review
#16
Tessa A Kouwenhoven, Peter C M van de Kerkhof, Marijke Kamsteeg
BACKGROUND: Chronic pruritus is a common skin symptom with marked impact on quality of life. Adequate treatment can be challenging for clinicians, demanding the exploration of new treatment options such as oral antidepressants. OBJECTIVE: To evaluate the use of oral antidepressants in chronic pruritus by a systematic overview of the available relevant literature. METHODS: The PubMed, EMBASE, Cochrane, and Web of Science databases were searched...
October 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29024676/perinatal-fluoxetine-prevents-the-effect-of-pre-gestational-maternal-stress-on-5-ht-in-the-pfc-but-maternal-stress-has-enduring-effects-on-mpfc-synaptic-structure-in-offspring
#17
Mary Gemmel, Nikolaos Kokras, Christina Dalla, Jodi L Pawluski
Maternal affective disorders are frequently treated with selective serotonin reuptake inhibitor medications (SSRIs); with up to 10% of women being prescribed these medications during pregnancy. Infant development depends on the early serotonergic environment, which is altered by perinatal SSRIs, raising concern about how these medications affect neural outcomes. While clinical and preclinical research suggests an impact of SSRIs on the developing brain, more research is needed to determine the effects on neuroplasticity, the serotonergic system, and the hypothalamic-pituitary-adrenal axis in neural regions mediating behavior...
October 9, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29020387/reversal-of-stress-induced-social-interaction-deficits-by-buprenorphine
#18
Caroline A Browne, Edgardo Falcon, Shivon A Robinson, Olivier Berton, Irwin Lucki
Background: Patients with post-traumatic stress disorder (PTSD) frequently report persistent problems with social interactions, emerging after a traumatic experience. Chronic social defeat stress (CSDS) is a widely used rodent model of stress that produces robust and sustained social avoidance behavior. The avoidance of other rodents can be reversed by 28 days of treatment with selective serotonin reuptake inhibitors (SSRIs), the only pharmaceutical class approved by the U. S. Food and Drug Administration for treating PTSD...
August 31, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29018756/descemet-s-stripping-automated-endothelial-keratoplasty-for-symptomatic-thioridazine-deposits-in-the-cornea
#19
Masoumeh Mohebbi, Hassan Hashemi, Alireza Mahmoudi, Pasha Anvari
The aim of this study was to use Descemet's Stripping-automated Endothelial Keratoplasty (DSAEK) as a novel treatment to remove thioridazine corneal deposits. A 53-year-old female presented with a 3-month history of visual loss and glare. She had been taking thioridazine (100 mg/day for 1 year) for a psychiatric disorder. Dense yellowish-brown deposits had developed in the posterior stroma. Thioridazine was discontinued, and she was switched to fluoxetine. One year after discontinuation of thioridazine, her symptoms and signs did not resolve...
January 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29016792/antidepressant-like-actions-of-inhibitors-of-poly-adp-ribose-polymerase-in-rodent-models
#20
Gregory A Ordway, Attila Szebeni, Liza J Hernandez, Jessica D Crawford, Katalin Szebeni, Michelle J Chandley, Katherine C Burgess, Corwin Miller, Erol Bakkalbasi, Russell W Brown
Background: Many patients suffering from depressive disorders are refractory to treatment with currently available antidepressant medications, while many more exhibit only a partial response. These factors drive research to discover new pharmacological approaches to treat depression. Numerous studies demonstrate evidence of inflammation and elevated oxidative stress in major depression. Recently, major depression has been shown to be associated with elevated levels of DNA oxidation in brain cells, accompanied by increased gene expression of the nuclear base excision repair enzyme, poly(ADP-ribose) polymerase-1...
August 3, 2017: International Journal of Neuropsychopharmacology
keyword
keyword
29424
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"