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https://www.readbyqxmd.com/read/29228200/ect-has-greater-efficacy-than-fluoxetine-in-alleviating-the-burden-of-illness-for-patients-with-major-depressive-disorder-a-taiwanese-pooled-analysis
#1
Ching-Hua Lin, Chun-Jen Huang, Cheng-Chung Chen
Background: The burden of major depressive disorder (MDD) includes suffering due to symptom severity, functional impairment, and quality of life (QOL) deficits. The aim of this study was to compare the differences between ECT and pharmacotherapy in reducing such burdens. Methods: This was a pooled analysis study including two open-label trials for MDD inpatients receiving either standard bitemporal and modified ECT with a maximum of 12 sessions, or 20 mg/d of fluoxetine for 6 weeks...
December 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29222907/the-ameliorative-effect-of-fluoxetine-on-neuroinflammation-induced-by-sleep-deprivation
#2
Maosheng Xia, Xiaowei Li, Li Yang, Jiaan Ren, Guangfeng Sun, Shuang Qi, Alexei Verkhratsky, Baoman Li
It is well known that sleep disorders are harmful to people's health and performance, and growing evidence suggests that sleep deprivation (SD) can trigger neuroinflammation in the brain. The nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasome is reported to be relevant to the neuroinflammation induced by SD, but the regulatory signaling that governs the NLRP3 inflammasome in SD is still unknown. Meanwhile, whether the regulatory action of antidepressants in astrocytes could affect the neuroinflammation induced by SD also remains obscure...
December 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29215318/therapeutic-potential-of-silymarin-in-chronic-unpredictable-mild-stress-induced-depressive-like-behavior-in-mice
#3
Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Patel
Silymarin, a plant-derived polyphenolic flavonoid of Silybum marianum, elicited significant antidepressant-like activity in an acute restraint stress model of depression. It improved monoamines, mainly 5-hydroxytryptamine (5-HT) levels in the cortex, dopamine (DA) and norepinephrine (NE) in the cerebellum in mice. The present study was undertaken to explore the antidepressant potential of silymarin in chronic unpredictable mild stress (CUMS) induced depressive-like behavior in mice, and to find out its probable mechanism(s) of action, mainly neurogenesis, neuroinflammation, and/or oxidative stress...
December 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29212586/hypercortisolemia-and-depressive-like-behaviors-in-a-rhesus-macaque-macaca-mulatta-involved-in-visual-research
#4
Sean C Adams, Christine M Guyot, Kristina M Berry, Seth T Wallack, Andrew S Loar, Mathias Leblanc
A 10-y-old cranially implanted rhesus macaque (Macaca mulatta) involved in visual research was presented for dull mentation and weight loss. Physical examination revealed alopecia and poor body conditioning, and bloodwork revealed marked hypercortisolemia (23 μg/dL). Differential diagnoses for hypercortisolemia, weight loss, and alopecia included Cushing and pseudo-Cushing syndromes. To further evaluate hypercortisolemia, we compared the urine cortisol:creatinine ratio (UCCR) at baseline and after low-dose dexamethasone suppression (LDDS) testing in the presenting animal and healthy naïve and implanted working monkeys...
December 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/29208964/reduced-anxiety-is-associated-with-the-accumulation-of-six-serotonin-reuptake-inhibitors-in-wastewater-treatment-effluent-exposed-goldfish-carassius-auratus
#5
D B D Simmons, E S McCallum, S Balshine, B Chandramouli, J Cosgrove, J P Sherry
Pharmaceuticals and personal care products (PPCPs) have been found in wastewater treatment plant (WWTP) effluents and their recipient watersheds. To assess the potential of WWTP effluents to alter fish behaviour, we caged male goldfish (Carassius auratus) for 21-days at three sites along a contamination gradient downstream from a WWTP which discharges into Cootes Paradise Marsh, on the western tip of Lake Ontario. We also included a fourth caging site as an external reference site within Lake Ontario at the Jordan Harbour Conservation Area...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29206826/-response-to-serotonergic-and-noradrenergic-antidepressants-a-crossover-study-of-fluoxetine-and-desipramine-in-patients-with-first-major-depression-episode
#6
José Alfonso Ontiveros-Sánchez de la Barquera
BACKGROUND: Response rate data from studies with different kinds of antidepressant drugs help in the development of guidelines for the rational prescription of pharmacotherapy. However, there are still few comparative studies with selective reuptake inhibition on serotonin or norepinephrine in the same sample of major depression patients. METHODS: First episode major depression (DSM-III-R) outpatients who completed 6 weeks in two double-blind randomized trials with fluoxetine and desipramine were crossed over to treatment with the other drug under open conditions for 6 weeks...
November 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29204954/chronic-fluoxetine-induces-activity-changes-in-recovery-from-poststroke-anxiety-depression-and-cognitive-impairment
#7
Faranak Vahid-Ansari, Paul R Albert
Poststroke depression (PSD) is a common outcome of stroke that limits recovery and is only partially responsive to chronic antidepressant treatment. In order to elucidate changes in the cortical-limbic circuitry associated with PSD and its treatment, we examined a novel mouse model of persistent PSD. Focal endothelin-1-induced ischemia of the left medial prefrontal cortex (mPFC) in male C57BL6 mice resulted in a chronic anxiety and depression phenotype. Here, we show severe cognitive impairment in spatial learning and memory in the stroke mice...
December 4, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29203420/compound-action-potential-inhibition-produced-by-various-antidepressants-in-the-frog-sciatic-nerve
#8
Ryo Hirao, Tsugumi Fujita, Aiko Sakai, Eiichi Kumamoto
Although an inhibition of action potential conduction in nerve fibers possibly contributes to at least a part of antinociception produced by analgesics and the adjuvants, it has not been fully examined yet how the conduction inhibition differs in extent among their drugs. We investigated the effects of various antidepressants used as analgesic adjuvants on compound action potentials (CAPs) recorded from the frog sciatic nerve by using the air-gap method. The results were compared with those of the other adjuvants that were reported previously...
December 1, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29203333/perinatal-fluoxetine-increases-hippocampal-neurogenesis-and-reverses-the-lasting-effects-of-pre-gestational-stress-on-serum-corticosterone-but-not-on-maternal-behavior-in-the-rat-dam
#9
Mary Gemmel, Danny Harmeyer, Eszter Bögi, Marianne Fillet, Lesley A Hill, Geoffrey L Hammond, Thierry D Charlier, Jodi L Pawluski
There is increasing evidence that mental health concerns, stress-related mental illnesses, and parental stress prior to conception have long-term effects on offspring outcomes. However, more work is needed to understand how pre-gestational stress might affect neurobehavioral outcomes in the mother. We investigated how chronic stress prior to gestation affects the maternal behavior and related physiology, and aimed to determine the role that perinatal SSRIs may have in altering these stress effects. To do this, female Sprague-Dawley rats were subject to chronic unpredictable stress (CUS) prior to breeding and during the perinatal period they were administered fluoxetine (10mg/kg/day)...
December 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29202894/failure-to-detect-the-action-of-antidepressants-in-the-forced-swim-test-in-swiss-mice
#10
Patrick R Suman, Nathalia Zerbinatti, Lais Cristina Theindl, Karolina Domingues, Cilene Lino de Oliveira
OBJECTIVE: The aims of this study were to replicate previously published experiments and to modify the protocol to detect the effects of chronic antidepressant treatment in mice. METHODS: Male Swiss mice (n=6-8/group) housed in reversed light/dark cycle were randomly assigned into receive vehicle (10% sucrose), sub-effective doses (1 and 3 mg/kg) or effective doses (10 and 30 mg/kg) of bupropion, desipramine, and fluoxetine and a candidate antidepressant, sodium butyrate (1-30 mg/kg) per gavage (p...
December 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29202289/concentrating-mixtures-of-neuroactive-pharmaceuticals-and-altered-neurotransmitter-levels-in-the-brain-of-fish-exposed-to-a-wastewater-effluent
#11
Arthur David, Anke Lange, Charles R Tyler, Elizabeth M Hill
Fish can be exposed to a variety of neuroactive pharmaceuticals via the effluent discharges from wastewater treatment plants and concerns have arisen regarding their potential impacts on fish behaviour and ecology. In this study, we investigated the uptake of 14 neuroactive pharmaceuticals from a treated wastewater effluent into blood plasma and brain regions of roach (Rutilus rutilus) after exposure for 15days. We show that a complex mixture of pharmaceuticals including, 6 selective serotonin reuptake inhibitors, a serotonin-noradrenaline reuptake inhibitor, 3 atypical antipsychotics, 2 tricyclic antidepressants and a benzodiazepine, concentrate in different regions of the brain including the telencephalon, hypothalamus, optic tectum and hindbrain of effluent-exposed fish...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29201187/shuyu-capsules-relieve-liver-qi-depression-by-regulating-erk-creb-bdnf-signal-pathway-in-central-nervous-system-of-rat
#12
Hongyan Wang, Yingquan Zhang, Helou Li, Wei Zeng, Mingqi Qiao
The purpose of this study was to investigate the possible therapeutic mechanism of Shuyu capsules in liver-qi depression. Liver-qi depression rats were prepared based on chronic unpredictable mild stress (CUMS) and delayed constraint. Rats were gavaged with Shuyu capsule, fluoxetine, Radix Bupleuri and Radix Paeoniae Alba to constrct rat models. Body weight test, sucrose preference test and open-field test were applied to test rat models. Western blot analysis and quantitative real-time PCR was applied to determine the relative expression of extracellular signal-regulated protein kinase (ERK), cyclic AMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in hippocampus and frontal lobe tissues...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29201116/fluoxetine-regulates-ig-kappa-chain-c-region-expression-levels-in-the-serum-of-obsessive-compulsive-disorder-patients-a-proteomic-approach
#13
Mona Zamanian Azodi, Mostafa Rezaei Tavirani, Afsaneh Arefi Oskouie, Mostafa Hamdieh, Mohammad Kamran Derakhshan, Alireza Ahmadzadeh, Farid Zayeri, Naser Nejadi, Majid Rezaei Tavirani, Vahid Mansouri, Mohammad Rostami-Nejad, Reza Vafaee
Obsessive-Compulsive Disorder (OCD) is one of the most common mental conditions. Proteome profiling may help identifying important proteins and finally shed lights to complexity of OCD underlying mechanisms. Here, by the application gel-based proteomic approach the proteome profile of patients with washing subtype of OCD before and after treatment with Fluoxetine (positive responders) are compared to healthy matched controls. However, only one of the differentially expressed proteins is examined and introduced in this paper...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29200995/ssri-and-motor-recovery-in-stroke-reestablishment-of-inhibitory-neural-network-tonus
#14
Camila B Pinto, Faddi G Saleh Velez, Fernanda Lopes, Polyana V de Toledo Piza, Laura Dipietro, Qing M Wang, Nicole L Mazwi, Erica C Camargo, Randie Black-Schaffer, Felipe Fregni
Selective serotonin reuptake inhibitors (SSRIs) are currently widely used in the field of the neuromodulation not only because of their anti-depressive effects but also due to their ability to promote plasticity and enhance motor recovery in patients with stroke. Recent studies showed that fluoxetine promotes motor recovery after stroke through its effects on the serotonergic system enhancing motor outputs and facilitating long term potentiation, key factors in motor neural plasticity. However, little is known in regards of the exact mechanisms underlying these effects and several aspects of it remain poorly understood...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29197272/efficient-synthesis-of-a-s-fluoxetine-intermediate-using-carbonyl-reductase-coupled-with-glucose-dehydrogenase
#15
Yunping Tang, Guomei Zhang, Zheng Wang, Dan Liu, Linglu Zhang, Yafeng Zhou, Ju Huang, Fangmiao Yu, Zuisu Yang, Guofang Ding
(S)-3-chloro-1-phenyl-1-propanol ((S)-CPPO) is an important chiral intermediate predominantly used in the synthesis of the chiral side chain of (S)-fluoxetine. In this study, carbonyl reductase (CBR) from Novosphingobium aromaticivorans was successfully expressed in recombinant E. coli. The enzymatic activity of the recombinant CBR was significantly increased to 1875 U/mL in the fed-batch fermentation in a 10 L fermenter and recombinant CBR was then purified and characterized. By regenerating NADH with glucose dehydrogenase, 100 g/L 3-chloro-1-phenyl-1-propanone (3-CPP) was successfully converted to (S)-CPPO with a conversion of 100% and ee value of 99...
November 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29197244/systematic-assessment-of-different-solvents-for-the-extraction-of-drugs-of-abuse-and-pharmaceuticals-from-an-authentic-hair-pool
#16
Milena M Madry, Thomas Kraemer, Markus R Baumgartner
Hair analysis has been established as a prevalent tool for retrospective drug monitoring. In this study, different extraction solvents for the determination of drugs of abuse and pharmaceuticals in hair were evaluated for their efficiency. A pool of authentic hair from drug users was used for extraction experiments. Hair was pulverized and extracted in triplicate with seven different solvents in a one- or two-step extraction. Three one- (methanol, acetonitrile, and acetonitrile/water) and four two-step extractions (methanol two-fold, methanol and methanol/acetonitrile/formate buffer, methanol and methanol/formate buffer, and methanol and methanol/hydrochloric acid) were tested under accurately equal experimental conditions...
November 23, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29192458/-exploring-the-clinical-characters-of-shugan-jieyu-capsule-through-text-mining
#17
Zheng-Ping Pu, Jiang-Ming Xia, Wei Xie, Jin-Cai He
The study was main to explore the clinical characters of Shugan Jieyu capsule through text mining. The data sets of Shugan Jieyu capsule were downloaded from CMCC database by the method of literature retrieved from May 2009 to Jan 2016. Rules of Chinese medical patterns, diseases, symptoms and combination treatment were mined out by data slicing algorithm, and they were demonstrated in frequency tables and two dimension based network. Then totally 190 literature were recruited. The outcomess suggested that SC was most frequently correlated with liver Qi stagnation...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29189044/desvenlafaxine-versus-placebo-in-a-fluoxetine-referenced-study-of-children-and-adolescents-with-major-depressive-disorder
#18
Karen L Weihs, William Murphy, Richat Abbas, Deborah Chiles, Richard D England, Sara Ramaker, Dalia B Wajsbrot
OBJECTIVES: To evaluate the short-term efficacy and safety of desvenlafaxine (25-50 mg/d) compared with placebo in children and adolescents with major depressive disorder (MDD). METHODS: Outpatient children (7-11 years) and adolescents (12-17 years) who met DSM-IV-TR criteria for MDD and had screening and baseline Children's Depression Rating Scale-Revised (CDRS-R) total scores >40 were randomly assigned to 8-week treatment with placebo, desvenlafaxine (25, 35, or 50 mg/d based on baseline weight), or fluoxetine (20 mg/d)...
November 30, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29187754/fluoxetine-treatment-is-effective-in-a-rat-model-of-childhood-induced-post-traumatic-stress-disorder
#19
Lior Ariel, Sapir Inbar, Schachaf Edut, Gal Richter-Levin
Although selective serotonin reuptake inhibitors (SSRIs) are first-line treatment for post-traumatic stress disorder (PTSD) patients, their therapeutic efficacy is limited. Childhood adversities are considered a risk factor for developing PTSD in adulthood but may trigger PTSD without additional trauma in some individuals. Nevertheless, just as childhood is considered a vulnerable period it may also be an effective period for preventive treatment. Using a rat model of childhood-induced PTSD, pre-pubertal stress (juvenile stress, JVS), we compared the therapeutic effects of fluoxetine and examined the effectiveness of 1 month of fluoxetine treatment following JVS and into adulthood compared to treatment in adulthood...
November 30, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29180675/protein-kinase-m%C3%AE-in-medial-prefrontal-cortex-mediates-depressive-like-behavior-and-antidepressant-response
#20
W Yan, J-F Liu, Y Han, W Zhang, Y-X Luo, Y-X Xue, W-L Zhu, C Yang, W-H Chen, H-L Guo, Y-N Ma, K Yuan, J-S Wang, J Shi, L Lu
Neuronal atrophy and alterations of synaptic structure and function in the medial prefrontal cortex (mPFC) have been implicated in the pathogenesis of depression, but the underlying molecular mechanisms are largely unknown. The protein kinase Mζ (PKMζ), a brain-specific atypical protein kinase C isoform, is important for maintaining long-term potentiation and storing memory. In the present study, we explored the role of PKMζ in mPFC in two rat models of depression, chronic unpredictable stress (CUS) and learned helplessness...
November 28, 2017: Molecular Psychiatry
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