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https://www.readbyqxmd.com/read/28439104/a-novel-5ht3-receptor-igf1-mechanism-distinct-from-ssri-induced-antidepressant-effects
#1
M Kondo, Y Koyama, Y Nakamura, S Shimada
Depression is a common mental disorder affecting around 350 million people worldwide. Although selective serotonin reuptake inhibitors (SSRIs) are the most widely used antidepressants, a significant proportion of depressed patients do not achieve remission with SSRIs. In this study, we show that a serotonin type 3 receptor (5HT3R) agonist induces antidepressant effects as well as hippocampal neurogenesis independent of fluoxetine (a commonly used SSRI). Notably, our histological analysis reveals that 5HT3R and insulin-like growth factor 1 (IGF1) are expressed in the same neurons in the subgranular zone of the hippocampal dentate gyrus...
April 25, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28438149/anti-depressant-and-anxiolytic-potential-of-acacia-hydaspica-r-parker-aerial-parts-extract-modulation-of-brain-antioxidant-enzyme-status
#2
Tayyaba Afsar, Suhail Razak, Muhammad Rashid Khan, Ali Almajwal
BACKGROUND: Oxidative stress may link to psychiatric disorders, and is being regarded as a plausible mechanism that can affect the regulation of these illnesses. The present study was undertaken to investigate the antidepressant and anxiolytic potential of A. hydaspica R. parkers. Brain oxidative stress enzyme levels were analyzed to correlate depression and stress with brain antioxidant status. METHODS: Antidepressant and anxiolytic effect of methanol extract of A...
April 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28436756/the-role-of-attachment-style-in-interpersonal-psychotherapy-for-depressed-adolescents
#3
Meredith Gunlicks-Stoessel, Ana Westervelt, Kristina Reigstad, Laura Mufson, Susanne Lee
OBJECTIVE(S): This study examined changes in depressed adolescents' reports of attachment anxiety and avoidance with interpersonal psychotherapy (IPT-A), and the relationship between attachment style and change in depression with IPT-A. METHOD: Forty adolescents (aged 12-17) participated in a 16-week randomized clinical trial of 4 adaptive treatment strategies for adolescent depression that began with IPT-A and augmented treatment for insufficient responders (n = 22) by adding additional IPT-A sessions (n = 11) or the antidepressant medication, fluoxetine (n = 11)...
April 24, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28431972/mitochondrial-energy-metabolism-of-rat-hippocampus-after-treatment-with-the-antidepressants-desipramine-and-fluoxetine
#4
Roberto Federico Villa, Federica Ferrari, Laura Bagini, Antonella Gorini, Nicoletta Brunello, Fabio Tascedda
Alterations in mitochondrial functions have been hypothesized to participate in the pathogenesis of depression, because brain bioenergetic abnormalities have been detected in depressed patients by neuroimaging in vivo studies. However, this hypothesis is not clearly demonstrated in experimental studies: some suggest that antidepressants are inhibitors of mitochondrial metabolism, while others observe the opposite. In this study, the effects of 21-day treatment with desipramine (15 mg/kg) and fluoxetine (10 mg/kg) were examined on the energy metabolism of rat hippocampus, evaluating the catalytic activity of regulatory enzymes of mitochondrial energy-yielding metabolic pathways...
April 18, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28430602/fluoxetine-attenuates-the-impairment-of-spatial-learning-ability-and-prevents-neuron-loss-in-middle-aged-appswe-psen1de9-double-transgenic-alzheimer-s-disease-mice
#5
Jing Ma, Yuan Gao, Lin Jiang, Feng-Lei Chao, Wei Huang, Chun-Ni Zhou, Wei Tang, Lei Zhang, Chun-Xia Huang, Yi Zhang, Yan-Min Luo, Qian Xiao, Hua-Rong Yu, Rong Jiang, Yong Tang
Selective serotonin reuptake inhibitors (SSRIs) have been reported to increase cognitive performance in some clinical studies of Alzheimer's disease (AD). However, there is a lack of evidence supporting the efficacy of SSRIs as cognition enhancers in AD, and the role of SSRIs as a treatment for AD remains largely unclear. Here, we characterized the impact of fluoxetine (FLX), a well-known SSRI, on neurons in the dentate gyrus (DG) and in CA1 and CA3 of the hippocampus of middle-aged (16 to 17 months old) APPswe/PSEN1dE9 (APP/PS1) transgenic AD model mice...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429110/inhibition-of-the-crf1-receptor-influences-the-activity-of-antidepressant-drugs-in-the-forced-swim-test-in-rats
#6
Andrzej Wróbel, Anna Serefko, Aleksandra Szopa, Karol Rojek, Ewa Poleszak, Krystyna Skalicka-Woźniak, Jarosław Dudka
Hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA) and impairment of the central corticotropin-releasing factor (CRF) system are factors in the pathogenesis of depression. Though several antagonists of the CRF1 receptor were effective in the recognized behavioral tests for antidepressant activity, there is still little information on the potential interactions between CRF1 receptor inhibitors and conventional antidepressant therapy. The aim of our study was to assess the influence of SN003, a CRF1 receptor blocker, on the activity of imipramine and fluoxetine in the forced swim test (FST) in rats which presented some signs of depression...
April 20, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28428751/identification-of-nf-%C3%AE%C2%BAb-as-determinant-of-posttraumatic-stress-disorder-and-its-inhibition-by-the-chinese-herbal-remedy-free-and-easy-wanderer
#7
Chunlan Hong, Anja Schüffler, Ulrich Kauhl, Jingming Cao, Ching-Fen Wu, Till Opatz, Eckhard Thines, Thomas Efferth
Posttraumatic stress disorder (PTSD) is a mental disorder developing after exposure to traumatic events. Although psychotherapy reveals some therapeutic effectiveness, clinically sustainable cure is still uncertain. Some Chinese herbal formulae are reported to work well clinically against mental diseases in Asian countries, but the safety and their mode of action are still unclear. In this study, we investigated the mechanisms of Chinese remedy free and easy wanderer (FAEW) on PTSD. We used a reverse pharmacology approach combining clinical data to search for mechanisms of PTSD with subsequent in vitro verification and bioinformatics techniques as follows: (1) by analyzing microarray-based transcriptome-wide mRNA expression profiling of PTSD patients; (2) by investigating the effect of FAEW and the antidepressant control drug fluoxetine on the transcription factor NF-κB using reporter cell assays and western blotting; (3) by performing molecular docking and literature data mining based on phytochemical constituents of FAEW...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28420875/down-regulation-of-cholinergic-signaling-in-the-habenula-induces-anhedonia-like-behavior
#8
Seungrie Han, Soo Hyun Yang, Jin Yong Kim, Seojung Mo, Esther Yang, Ki Myung Song, Byung-Joo Ham, Naguib Mechawar, Gustavo Turecki, Hyun Woo Lee, Hyun Kim
Dysfunction of cholinergic signaling in the brain has long been believed to be associated with depressive disorders. However, the functional impact of habenular cholinergic signaling on the specified depressive behaviors is not well understood. Here, we demonstrated that the expression levels of cholinergic signaling genes (CHAT, VACHT, CHT, CHRNA3, CHRNB3 and CHRNB4) were down-regulated in a chronic restraint stress (CRS) rat model of depression, in which rats display depression-like behaviors such as anhedonia and mood despair...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28418941/prenatal-fluoxetine-modifies-the-behavioral-and-hormonal-responses-to-stress-in-male-mice-role-for-glucocorticoid-insensitivity
#9
Ronit Avitsur
Women with major depressive disorder during pregnancy often use selective serotonin reuptake inhibitors (SSRIs) antidepressants. These drugs readily cross the placental barrier and impact the developing fetal brain. Recently, we reported that prenatal fluoxetine (FLX), an SSRI antidepressant drug, altered corticosterone and behavioral responses to stress in female mouse offspring. The present study assessed the effects of prenatal FLX on these responses in males. The results showed that prenatal FLX significantly augmented the corticosterone response to acute stress in young prepubescent mice...
April 17, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28417659/effects-of-nphe-1-arg-14-lys-15-n-ofq-nh2-ufp-101-a-potent-nop-receptor-antagonist-on-molecular-cellular-and-behavioural-alterations-associated-with-chronic-mild-stress
#10
Giovanni Vitale, Monica Filaferro, Maria Vittoria Micioni Di Bonaventura, Valentina Ruggieri, Carlo Cifani, Remo Guerrini, Michele Simonato, Silvia Zucchini
The present study investigated the effect of [Nphe(1)] Arg(14), Lys(15)-N/OFQ-NH2 (UFP-101), a selective NOP receptor antagonist, in chronic mild stress (CMS) in male Wistar rats. NOP receptor antagonists were reported to elicit antidepressant-like effects in rodents. Our aim was to investigate UFP-101 effects on CMS-induced anhedonia and impairment of hippocampal neurogenesis. UFP-101 (10 nmol/rat intracerebroventricularly) did not influence sucrose intake in non-stressed animals, but reinstated basal sucrose consumption in stressed animals from the second week of treatment...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28416380/spinal-dopaminergic-involvement-in-the-antihyperalgesic-effect-of-antidepressants-in-a-rat-model-of-neuropathic-pain
#11
Mi Chen, Hajime Hoshino, Shigeru Saito, Yang Yang, Hideaki Obata
Antidepressants such as tricyclic antidepressants, and serotonin noradrenaline reuptake inhibitors are a first-line treatment for neuropathic pain. Here, we aimed to determine the involvement of the spinal dopaminergic system in the antihyperalgesic effects of antidepressants in a rat model of neuropathic pain induced by spinal nerve ligation (SNL). The right L5 spinal nerve of male Sprague-Dawley rats was ligated under inhalation anesthesia to induce hyperalgesia. Behavioral testing was performed by measuring ipsilateral hindpaw withdrawal thresholds after intraperitoneal injection of amitriptyline, duloxetine, milnacipran, and fluoxetine...
April 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28412215/involvement-of-serotonergic-noradrenergic-and-dopaminergic-systems-in-the-antidepressant-like-effect-of-ginsenoside-rb1-a-major-active-ingredient-of-panax-ginseng-c-a-meyer
#12
Guo-Li Wang, Zhong-Mei He, Hong-Yan Zhu, Yu-Gang Gao, Yan Zhao, He Yang, Liangxue Zhang
ETHNOPHARMACOLOGY RELEVANCE: Ginsenoside Rb1, a 20 (S)-protopanaxadiol, is a major active ingredient of Panax ginseng C.A. Meyer, which as the King of Chinese herbs, has been wildly used for the treatment of central nervous system diseases. Previous studies have shown that 20 (S)-protopanaxadiol possesses a novel antidepressant-like effect in the treatment of depression, whereas ginsenoside Rb1 in depression has been rarely reported. AIM OF THE REVIEW: The present study was to investigate the antidepressant-like effect of ginsenoside Rb1 and its relevant mechanisms...
April 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28411060/in%C3%A2-vitro-anti-candida-activity-of-selective-serotonin-reuptake-inhibitors-against-fluconazole-resistant-strains-and-their-activity-against-biofilm-forming-isolates
#13
Rose Anny Costa Silva, Cecília Rocha da Silva, João Batista de Andrade Neto, Anderson Ramos da Silva, Rosana Sousa Campos, Letícia Serpa Sampaio, Francisca Bruna Stefany Aires do Nascimento, Brenda da Silva Gaspar, Said Gonçalves da Cruz Fonseca, Maria Aparecida Alexandre Josino, Thalles Barbosa Grangeiro, Danielle Macedo Gaspar, David Freitas de Lucena, Manoel Odorico de Moraes, Bruno Coêlho Cavalcanti, Hélio Vitoriano Nobre Júnior
Recent research has shown broad antifungal activity of the classic antidepressants selective serotonin reuptake inhibitors (SSRIs). This fact, combined with the increased cross-resistance frequency of the genre Candida regarding the main treatment today, fluconazole, requires the development of novel therapeutic strategies. In that context, this study aimed to assess the antifungal potential of fluoxetine, sertraline, and paroxetine against fluconazole-resistant Candida spp. planktonic cells, as well as to assess the mechanism of action and the viability of biofilms treated with fluoxetine...
April 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28411001/interstitial-lung-disease-induced-by-fluoxetine-systematic-review-of-literature-and-analysis-of-vigiaccess-eudravigilance-and-a-national-pharmacovigilance-database
#14
REVIEW
Arianna Deidda, Claudia Pisanu, Laura Micheletto, Alberto Bocchetta, Maria Del Zompo, Maria Erminia Stochino
We investigated a pulmonary adverse drug reaction possibly induced by fluoxetine, the Interstitial Lung Disease, by performing a systematic review of published case reports on this subject, a review of the World Health Organization VigiAccess database, of the European EudraVigilance database and of a national Pharmacovigilance database (Italian Pharmacovigilance Network). The research found a total of seven cases linking fluoxetine to Interstitial Lung Disease in the literature. 36 cases of interstitial lung disease related to fluoxetine were retrieved from the VigiAccess database (updated to July 2016), and 36 reports were found in EudraVigilance database (updated to June 2016)...
April 12, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28407315/drugs-with-antidepressant-properties-affect-tryptophan-metabolites-differently-in-rodent-models-with-depression-like-behavior
#15
Amanda Eskelund, Yan Li, David P Budac, Heidi K Müller, Gulinello Maria, Connie Sanchez, Gregers Wegener
The metabolism of tryptophan through kynurenine and serotonin pathways is linked to depression. Here, effects of different drugs with antidepressant properties (vortioxetine, fluoxetine and ketamine) on various tryptophan metabolites in different brain regions and plasma were examined using tandem mass spectrometry (LC-MS/MS), in Flinders Sensitive Line (FSL) rats, a genetic rat model of depression, and its controls: Flinders Resistant Line (FRL) and Sprague-Dawley (SD) rats. Protein levels of kynurenine pathway enzymes were measured in the brains and livers of these rat strains...
April 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28403356/fluoxetine-effects-on-periodontogenesis-histomorphometrical-and-immunohistochemical-analyses-in-rats
#16
Luciana Silva Regueira, Priscylla Gonçalves Correia Leite de Marcelos, Isabela Maria Santiago-Jaegger, Danyel Elias da Cruz Perez, Joaquim Evêncio, Liriane Baratella-Evêncio
Objective: This study aimed to assess the effects of fluoxetine, a selective serotonin reuptake inhibitor, on the formation of the periodontal ligament during pregnancy and lactation in rat pups. Material and Methods: Twelve pregnant rats of Wistar lineage were divided into four study groups. In the control group, 0.9% sodium chloride solution was administered orally, throughout the entire period of the 21 days of pregnancy (CG group) and in the CGL group, it was administrated during pregnancy and lactation (from day 1 of pregnancy to the 21st day after birth)...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28401798/most-frequently-reported-prescription-medications-and-supplements-in-couples-planning-pregnancy-the-life-study
#17
Kristin Palmsten, Katrina F Flores, Christina D Chambers, Lauren A Weiss, Rajeshwari Sundaram, Germaine M Buck Louis
OBJECTIVE: To identify frequently reported prescription medications and supplements among couples planning pregnancy because there is a lack of descriptive information on these agents in women and men who are trying to conceive. METHODS: Five hundred one couples enrolled in the Longitudinal Study of Infertility and the Environment, which took place between 2005 and 2009. Participants reported prescription medications as well as prescription and over-the-counter supplements used through interviews at study enrollment and through daily dairies during the 12-month follow-up...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28396142/atypical-binding-at-dopamine-and-serotonin-transporters-contribute-to-the-discriminative-stimulus-effects-of-mephedrone
#18
Alyssa F DeLarge, Laura L Erwin, Peter J Winsauer
Mephedrone (4-methylmethcathinone), a constituent of the recreational substances known as "bath salts", is a synthetic cathinone that can produce auditory and visual hallucinations, as well as problematic cardiovascular effects. This study compared the discriminative stimulus effects of mephedrone (0.32-10 mg/kg) with other prototypical drugs of abuse: cocaine (0.56-32 mg/kg), d-amphetamine (0.18-3.2 mg/kg), ketamine (1.8-18 mg/kg), phencyclidine (PCP, 1-5.6 mg/kg), heroin (1-10 mg/kg), 2,5-dimethoxy-4-iodoamphetamine (R-DOI, 0...
April 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28395202/bioconcentration-of-the-antidepressant-fluoxetine-and-its-effects-on-the-physiological-and-biochemical-status-in-daphnia-magna
#19
Jiannan Ding, Hua Zou, Qingqing Liu, Shanshan Zhang, Roger Mamitiana Razanajatovo
The aim of this study was to evaluate the bioconcentration potential of fluoxetine and its biological effects in Daphnia magna. After 48h of waterborne exposure, the bioconcentration of fluoxetine in D. magna was determined to be 460.61 and 174.41Lkg(-1) for nominal exposure concentrations of 0.5 and 5µgL(-1), respectively. Moreover, various biological endpoints, including physiological responses (filtration and ingestion rates), enzymatic biomarkers related to neurotoxicity [acetylcholinesterase (AChE)] and antioxidant defense [superoxide dismutase (SOD)], and an oxidative stress damage marker [malondialdehyde (MDA)], were assessed...
April 7, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28393897/olanzapine-but-not-clozapine-increases-glutamate-release-in-the-prefrontal-cortex-of-freely-moving-mice-by-inhibiting-d-aspartate-oxidase-activity
#20
Silvia Sacchi, Vito De Novellis, Giovanna Paolone, Tommaso Nuzzo, Monica Iannotta, Carmela Belardo, Marta Squillace, Paolo Bolognesi, Elena Rosini, Zoraide Motta, Martina Frassineti, Alessandro Bertolino, Loredano Pollegioni, Michele Morari, Sabatino Maione, Francesco Errico, Alessandro Usiello
D-aspartate levels in the brain are regulated by the catabolic enzyme D-aspartate oxidase (DDO). D-aspartate activates NMDA receptors, and influences brain connectivity and behaviors relevant to schizophrenia in animal models. In addition, recent evidence reported a significant reduction of D-aspartate levels in the post-mortem brain of schizophrenia-affected patients, associated to higher DDO activity. In the present work, microdialysis experiments in freely moving mice revealed that exogenously administered D-aspartate efficiently cross the blood brain barrier and stimulates L-glutamate efflux in the prefrontal cortex (PFC)...
April 10, 2017: Scientific Reports
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