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https://www.readbyqxmd.com/read/29454288/apocynum-venetum-leaf-extract-reverses-depressive-like-behaviors-in-chronically-stressed-rats-by-inhibiting-oxidative-stress-and-apoptosis
#1
Xiangting Li, Ting Wu, Zhonghai Yu, Tingting Li, Jingsi Zhang, Zhennian Zhang, Min Cai, Wen Zhang, Jun Xiang, Dingfang Cai
BACKGROUND: Major depressive disorder (MDD) is a common but serious psychiatric disorder, but current treatments are inadequate for approximately half of the patients with MDD. Thus, better methods of treatment are urgently needed. This study aimed to investigate the antidepressant-like effects and potential mechanism of Apocynum venetum leaf extract (AVLE) in chronic unpredictable mild stress (CUMS) rat model of depression. MATERIALS AND METHODS: The CUMS rat model of depression was used to investigate the antidepressant-like activity and relevant mechanism of AVLE (30, 60, and 125 mg/kg, i...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29453913/chronic-fluoxetine-treatment-induces-lipid-accumulation-but-does-not-alter-the-expression-of-pref-1-in-rat-adipose-tissue
#2
László-István Bába, Zsolt Gáll, István Lóránt Bíró, Tibor Mezei, Imre Zoltán Kun, Melinda Kolcsár
This study aims to investigate the effects of chronic fluoxetine (FLX) treatment on preadipocyte factor-1 (Pref-1) expression in subcutaneous, visceral and brown adipose tissues, and on the size of vacuoles in a dipocytes obtained from the perirenal regions in rats. Twenty-eight Wistar rats were treated with FLX at two different doses and fourteen animals received vehicle. After 40 days of treatment, the subcutaneous, perirenal and interscapular adipose tissues were collected. Pref-1 expression was examined using an immunohistochemical method and the vacuolar area was measured in stained sections...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453444/positive-regulation-of-raphe-serotonin-neurons-by-serotonin-2b-receptors
#3
Arnauld Belmer, Emily Quentin, Silvina L Diaz, Bruno P Guiard, Sebastian P Fernandez, Stéphane Doly, Sophie M Banas, Pothitos M Pitychoutis, Imane Moutkine, Aude Muzerelle, Anna Tchenio, Anne Roumier, Manuel Mameli, Luc Maroteaux
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT 2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT 2B receptors in mice eliminates the effects of molecules that directly target serotonergic neurons including amphetamine derivative serotonin releasers, and selective serotonin reuptake inhibitor antidepressants. In this work, we tested the hypothesis that 5-HT 2B receptors directly and positively regulate raphe serotonin neuron activity...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29452193/antidepressant-activity-of-vorinostat-is-associated-with-amelioration-of-oxidative-stress-and-inflammation-in-a-corticosterone-induced-chronic-stress-model-in-mice
#4
Athira Kv, Rajaram Mohanrao Madhana, Indu Chandran Js, Mangala Lahkar, Swapnil Sinha, V G M Naidu
Major depressive disorder (MDD) is a multifactorial neuropsychiatric disorder. Chronic administration of corticosterone (CORT) to rodents is used to mimic the stress associated dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, a well-established feature found in depressive patients. Recently, preclinical studies have demonstrated the antidepressant potential of histone deacetylase (HDAC) inhibitors. So, we examined the antidepressant potential of vorinostat (VOR), a HDAC inhibitor against CORT injections in male mice...
February 13, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29451703/mechanisms-of-imidazoline-i-2-receptor-agonist-induced-antinociception-in-rats-involvement-of-monoaminergic-neurotransmission
#5
Justin N Siemian, Kaixuan Wang, Yanan Zhang, Jun-Xu Li
BACKGROUND AND PURPOSE: Although studies have established the antinociceptive efficacies of imidazoline I 2 receptor (I 2 R) agonists, its exact post-receptor mechanism remains unknown. This study tested the hypothesis that monoaminergic transmission is critical for I 2 R agonist-induced antinociception. EXPERIMENTAL APPROACH: The von Frey filament test was used to examine the antinociceptive effects of the I 2 R agonists 2-BFI and CR4056 on chronic constriction injury (CCI)-induced neuropathic pain or complete Freund's adjuvant (CFA)-induced inflammatory pain in rats...
February 16, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29438781/neurobiological-links-between-depression-and-ad-the-role-of-tgf-%C3%AE-1-signaling-as-a-new-pharmacological-target
#6
REVIEW
Filippo Caraci, Simona Federica Spampinato, Maria Grazia Morgese, Fabio Tascedda, Maria Grazia Salluzzo, Maria Concetta Giambirtone, Giuseppe Caruso, Antonio Munafò, Sebastiano Alfio Torrisi, Gian Marco Leggio, Luigia Trabace, Ferdinando Nicoletti, Filippo Drago, Maria Angela Sortino, Agata Copani
In the last several years a large number of studies have demonstrated the neurobiological and clinical continuum between depression and Alzheimer's disease (AD). Depression is a risk factor for the development of AD, and the presence of depressive symptoms significantly increases the conversion of Mild Cognitive Impairment (MCI) into AD. Common pathophysiological events have been identified in depression and AD, including neuroinflammation with an aberrant Tumor Necrosis Factor-α (TNF-α) signaling, and an impairment of Brain-Derived Neurotrophic Factor (BDNF) and Transforming-Growth-Factor-β1 (TGF-β1) signaling...
February 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29436984/effectiveness-of-pharmacological-or-psychological-interventions-for-smoking-cessation-in-smokers-with-major-depression-or-depressive-symptoms-a-systematic-review-of-the-literature
#7
Giulia A Aldi, Giuly Bertoli, Francesca Ferraro, Aldo Pezzuto, Fiammetta Cosci
BACKGROUND: Smokers with major depressive disorder (MDD) or depressive symptoms (DS) represent a subgroup in need of attention since they have specific clinical features and prognosis. METHODS: A systematic review of the literature (Cochrane, MEDLINE, ScienceDirect, Web Of Science databases from inception to June 2017) of randomized clinical trials assessing the effectiveness of pharmacological, psychological or combined interventions for smoking cessation in subjects with current or past MDD/DS without medical or comorbid psychiatric disorder(s) was run following the PRISMA guidelines...
February 13, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29427083/fluoxetine-inhibits-natural-decay-of-long-term-memory-via-akt-gsk-3%C3%AE-signaling
#8
Jee Hyun Yi, JiaBao Zhang, Sang Yoon Ko, Huiyoung Kwon, Se Jin Jeon, Se Jin Park, Jiwook Jung, Byung C Kim, Young Choon Lee, Dong Hyun Kim, Jong Hoon Ryu
Understanding the mechanisms underlying the natural decay of long-term memory can help us find means of extending the duration of long-term memory. However, the neurobiological processes involved in the decay of long-term memory are poorly understood. In the present study, we examined the effect of acute and chronic treatment of fluoxetine on natural decay of long-term memory and the possible mechanism. Late administration of fluoxetine prolonged the persistence of long-term memory in mice, as demonstrated by object location recognition and Barnes maze tests...
February 9, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29423188/availability-of-brands-of-six-essential-medicines-in-124-pharmacies-in-maharashtra
#9
Colin Millard, Abhay B Kadam, Rushikesh Mahajan, Allyson M Pollock, Petra Brhlikova
Background: The aim of this study is to assess the availability and rational use of six essential medicines in private retail outlets in Maharashtra state. The study focuses on the range of brands for each medicine, and the availability of these brands in the pharmacies. The medicines were chosen because they are included in the World Health Organization's (WHO) essential medicines list (EML), the Indian national and Maharashtra state medicines list, and are all included in existing Indian public health initiatives and national disease control programmes...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29414147/clobenpropit-a-histamine-h3-receptor-antagonist-inverse-agonist-inhibits-3h-dopamine-uptake-by-human-neuroblastoma-sh-sy5y-cells-and-rat-brain-synaptosomes
#10
Elvia Mena-Avila, Ricardo Márquez-Gómez, Guillermo Aquino-Miranda, Gustavo Nieto-Alamilla, José-Antonio Arias-Montaño
BACKGROUND: Clobenpropit, a potent antagonist/inverse agonist at the histamine H3 receptor (H3R), reduced the cytotoxic action of 6-hydroxydopamine (6-OHDA) in neuroblastoma SH-SY5Y cells transfected with the human H3R. We therefore set out to study whether this effect involved a receptor-independent action on dopamine transport. METHODS: The uptake of [3H]-dopamine was assayed in SH-SY5Y cells and rat striatal or cerebro-cortical isolated nerve terminals (synaptosomes)...
August 30, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29405799/female-psychopharmacology-matters-towards-a-sex-specific-psychopharmacology
#11
Blanca Bolea-Alamanac, Sarah J Bailey, Thelma A Lovick, Dirk Scheele, Rita Valentino
There is increasing recognition that women have a higher prevalence of certain psychiatric illnesses, and a differential treatment response and course of illness compared to men. Additionally, clinicians deal with a number of disorders like premenstrual syndrome, premenstrual dysphoric disorder, and postpartum depression, which affect women specifically and for which treatment and biological pathways are still unclear. In this article we highlight recent research which suggests that different biological mechanisms may underlie sex differences in responsiveness to stress...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29397559/anti-oxidative-effects-of-melatonin-receptor-agonist-and-omega-3-polyunsaturated-fatty-acids-in-neuronal-sh-sy5y-cells-deciphering-synergic-effects-on-anti-depressant-mechanisms
#12
Senthil Kumaran Satyanarayanan, Yin-Hwa Shih, Yu-Chuan Chien, Shih-Yi Huang, Piotr Gałecki, Siegfried Kasper, Jane Pei-Chen Chang, Kuan-Pin Su
Omega-3 polyunsaturated fatty acids (n-3 or omega-3 PUFAs) and melatonin receptor agonist ramelteon (RMT) both display antidepressant effects, while their cellular effects on anti-oxidative and neuroprotective mechanisms might be different. In this study, we aimed to decipher the individual and synergistic actions of n-3 PUFAs and RMT, as compared with the conventional antidepressant fluoxetine (FLX), in a cellular model of oxidative stress, which might play an important role in the pathophysiology of depression and associated disorders...
February 3, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29395672/dok7-myasthenic-syndrome-with-subacute-adult-onset-during-pregnancy-and-partial-response-to-fluoxetine
#13
Mariana Santos, Simão Cruz, João Peres, Luís Santos, Purificação Tavares, Jorge Pinto Basto, Vasco Salgado, Ana Herrero Valverde
DOK7 congenital myasthenic syndrome (DOK7-CMS) generally presents early in life and is treated with salbutamol or ephedrine. This report describes an atypical case of a 39-year-old woman who presented with proximal upper limb weakness in the third trimester of pregnancy and was initially diagnosed with seronegative myasthenia gravis. Dramatic clinical worsening under pyridostigmine and further inefficacy of steroids, intravenous human immunoglobulin (IVIG) and plasma exchange (PLEX) led to the presumptive diagnosis of a CMS...
December 13, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29390069/long-non-coding-rna-associated-transcriptomic-changes-in-resiliency-or-susceptibility-to-depression-and-response-to-antidepressant-treatment
#14
Bhaskar Roy, Qingzhong Wang, Yogesh Dwivedi
Background: Recent emergence of long non-coding RNAs (lncRNAs) in regulating gene expression and thereby modulating physiological functions in brain has manifested their possible role in psychiatric disorders. In this study, the roles of lncRNAs in susceptibility and resiliency to develop stress-induced depression and their response to antidepressant treatment were examined. Methods: Microarray based transcriptome-wide changes in lncRNAs was determined in hippocampus of male Holtzman rats who showed susceptibility (learned helpless; LH) or resiliency (non-learned helpless; NLH) to develop depression...
January 30, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29388700/neonatal-treatment-with-fluoxetine-improves-mitochondrial-respiration-and-reduces-oxidative-stress-in-liver-of-adult-rats
#15
Aiany C Simões-Alves, Reginaldo C Silva-Filho, Glauber Ruda F Braz, Severina Cassia A Silva, Aline Isabel da Silva, Claudia J Lagranha, Mariana P Fernandes
Recent studies have shown that exposure to fluoxetine treatment induces excessive production of ROS, and alters the antioxidant defense system in various tissues and cell types, mainly the liver. When fluoxetine is administered intraperitoneally, the drug rapidly reaches high concentrations in the liver, has potentially multiple toxic effects on energy metabolism in rat liver mitochondria. The aim of this study was to evaluate the effect of pharmacological treatment with fluoxetine during critical period for development on the mitochondrial bioenergetics and oxidative stress in liver of rat adult...
February 1, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29388523/antidepressants-in-paediatric-depression-do-not-look-back-in-anger-but-around-in-awareness
#16
David A Brent, Robert D Gibbons, Paul Wilkinson, Bernadka Dubicka
In this paper, we summarise and critique a network meta-analysis (NMA) of antidepressant efficacy and tolerability for paediatric depression and an accompanying editorial. Although we agree that many of the extant studies are flawed, this meta-analysis showed clear efficacy of fluoxetine in the NMA, and for sertraline and escitalopram in pairwise analyses. Consequently, these papers underestimate the benefits of antidepressants for paediatric depression, and provide support for current practice guideline, which recommends the use of an antidepressant if the patient does not respond to psychotherapy...
February 2018: BJPsych Bulletin
https://www.readbyqxmd.com/read/29387573/saffron-improved-depression-and-reduced-homocysteine-level-in-patients-with-major-depression-a-randomized-double-blind-study
#17
Gholamali Jelodar, Zahra Javid, Ali Sahraian, Sina Jelodar
Objectives: A correlation between hyperhomocysteinemia, and depression has been reported. Saffron (Crocus sativus) is recommended for treatment of depression; hence, in this study the effect of co-administration of saffron and fluoxetine on plasma homocysteine and depression was evaluated. Material and methods: This was a 4-week randomized and double-blind clinical trial which was conducted from March 2013 to February 2014. In this trial, 40 male and females (20-55 years old) diagnosed with severe depression were selected and following filing the Beck form, were randomly divided into two groups...
January 2018: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29385813/the-role-of-musk-in-relieving-the-neurodegenerative-changes-induced-after-exposure-to-chronic-stress
#18
Manal Galal Abd El Wahab, Soad Shaker Ali, Nasra Naeim Ayuob
OBJECTIVE: This study aimed to evaluate the effect induced by musk on Alzheimer's disease-such as neurodegenerative changes in mice exposed to chronic unpredictable mild stress (CUMS). MATERIAL AND METHODS: Forty male Swiss albino mice were divided into 4 groups (n = 10); control, CUMS, CUMS + fluoxetine, CUMS + musk. At the end of the experiment, behavior of the mice was assessed. Serum corticosterone level, hippocampal protein level of the glucocorticoid receptors, and brain-derived neurotropic factor were also assessed...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29381222/therapeutic-strategies-for-congenital-myasthenic-syndromes
#19
REVIEW
Manon Lee, David Beeson, Jacqueline Palace
To date, more than 25 genes have been implicated in the etiology of the congenital myasthenic syndromes (CMS), and an ever-growing phenotypic landscape is now encountered in the CMS clinic. Unlike the autoimmune form of myasthenia, there is no role for immunomodulatory agents in the treatment of CMS. The present-day drug repertoire comprises acetylcholinesterase inhibitors (mainly pyridostigmine), 3,4-diaminopyridine (3,4-DAP), ephedrine, salbutamol/albuterol, open-channel blockers (fluoxetine, quinidine), or a combination of these...
January 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29379991/metformin-potentiates-cognitive-and-antidepressant-effects-of-fluoxetine-in-rats-exposed-to-chronic-restraint-stress-and-high-fat-diet-potential-involvement-of-hippocampal-c-jun-repression
#20
Sara A Khedr, Ahmed A Elmelgy, Omnyah A El-Kharashi, Hadwa A Abd-Alkhalek, Manal L Louka, Hoda A Sallam, Sawsan Aboul-Fotouh
Several hypotheses link high fat diet (HFD) with the pathophysiology of depression and its response to antidepressants. This study aimed to determine the effect of metformin (MET) on the cognitive and antidepressant activity of fluoxetine (FLU) through its effect on c-Jun expression. Behavioral, cognitive function, biochemical, and histopathological studies were performed in non-HFD- and HFD-fed rats exposed to chronic restraint stress (CRS). Stressed group showed cognitive impairment, depressive-like symptoms, disturbed glucose homeostasis and lipid profile, reduced adiponectin level, brain-derived neurotrophic factor (BDNF) expression, and increased corticosterone and c-Jun...
January 29, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
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