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REVIEW
Miray Atacan Yaşgüçlükal, Emel Ur Özçelik, Ayşe Deniz Elmali, Özlem Çokar, Veysi Demirbilek
INTRODUCTION: We aimed to investigate the long-term prognosis of childhood absence epilepsy (CAE), and identify factors associated with treatment outcomes. METHODS: Patients with a definitive diagnosis of CAE according to the International League Against Epilepsy 2021 criteria and with a minimum of 3-year follow-up duration were included. The children were divided according to the time of seizure control. Early seizure remission was defined as seizure freedom within 6 months after the treatment onset...
2024: Noro Psikiyatri Arsivi
#22
JOURNAL ARTICLE
Sleep Physiology and Neurocognition Among Adolescents With Attention-Deficit/Hyperactivity Disorder.
Jessica R Lunsford-Avery, Mary A Carskadon, Scott H Kollins, Andrew D Krystal
OBJECTIVE: Few studies have characterized the nature of sleep problems among adolescents with attention-deficit/hyperactivity disorder (ADHD) using polysomnography (PSG). Additionally, although adolescents with ADHD and those with sleep disturbances display similar neurocognitive deficits, the role of sleep in contributing to neurocognitive impairment in adolescent ADHD is unknown. This study investigates differences in PSG-measured sleep among adolescents with ADHD versus non-psychiatric controls (NPC) and associations with neurocognition...
March 7, 2024: Journal of the American Academy of Child and Adolescent Psychiatry
#23
JOURNAL ARTICLE
Ann M Iturra-Mena, Jason Moser, Dana E Díaz, Sherry Y H Chen, Katherine Rosenblum, Maria Muzik, Kate D Fitzgerald
BACKGROUND: Childhood anxiety symptoms have been linked with alterations in cognitive control and error-processing, yet the diverse findings on neural markers of anxiety in young children, varying by severity and developmental stages, suggest a need for a wider perspective. Integrating new neural markers with established ones like the Error-Related Negativity (ERN), the Error Positivity (Pe) and frontal theta, could clarify this association. Error-Related Alpha Suppression (ERAS) is a recently proposed index of post-error attentional engagement not yet explored in anxious children...
March 9, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
#24
RANDOMIZED CONTROLLED TRIAL
Yuh-Chuan Chen, Wen-Pin Chang, Kai-Jie Liang, Chia-Ling Chen, Hsin-Yung Chen, Shu-Ping Chen, Pei-Ying S Chan
BACKGROUND: Limited research exists regarding the effectiveness of electroencephalogram (EEG) neurofeedback training for children with cerebral palsy (CP) and co-occurring attention deficits (ADs), despite the increasing prevalence of these dual conditions. This study aimed to fill this gap by examining the impact of neurofeedback training on the attention levels of children with CP and AD. METHODS: Nineteen children with both CP and co-occurring ADs were randomly assigned to either a neurofeedback or control group...
March 2024: Child: Care, Health and Development
#25
REVIEW
Carrie R Muh, Jessica R Dorilio, Cameron P Beaudreault, Patricia E McGoldrick, Jared M Pisapia, Steven M Wolf
PURPOSE: Stereoelectroencephalography (SEEG) is a diagnostic surgery that implants electrodes to identify areas of epileptic onset in patients with drug-resistant epilepsy (DRE). SEEG is effective in identifying the epileptic zone; however, placement of electrodes in very young children has been considered contraindicated due to skull thinness. The goal of this study was to evaluate if SEEG is safe and accurate in young children with thin skulls. METHODS: Four children under the age of two years old with DRE underwent SEEG to locate the region of seizure onset...
March 7, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#26
JOURNAL ARTICLE
Chengyan Li, You Wang, Siqi Chen, Sinwen Rong, Binglong Huang, Ling Liu, Han Lou
OBJECTIVE: To explore the clinical phenotype and genetic etiology of a child with Developmental epileptic encephalopathy type 104 (DEE 104). METHODS: A child who had presented at the Children's Medical Center of the Affiliated Hospital of Guangdong Medical University in February 2021 for recurrent seizures over 1 month was selected as the study subject. Clinical data of the child was collected. Peripheral blood samples of the child and his parents were collected and subjected to whole exome sequencing (WES)...
March 10, 2024: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
#27
REVIEW
Jinfeng Liu, Jia Zhang, Yajun Shen, Yang Li, Huan Luo, Jing Gan
OBJECTIVE: To explore the clinical characteristics and genetic basis for a child with global developmental delay and autism. METHODS: A child who had presented at West China Second University Hospital of Sichuan University on April 13, 2021 was selected as the study subject. Clinical manifestations, laboratory examination and result of genetic testing were analyzed. RESULTS: The main symptoms of the child had included cognitive, language and motor delay, autism and epilepsy...
March 10, 2024: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
#28
JOURNAL ARTICLE
Xiaoyan Sun, Peng Wu, Yao Xue, Jie Huang, Rufeng Lin, Yongjun Fang
OBJECTIVE: Gaucher disease (GD) is a clinically rare single-gene recessive lysosomal storage disease mainly divided into three subtypes I to III. This report aims to present a case of type IIIb GD in a Chinese child with a focus on the manifestation of hearing loss and the importance of early diagnosis and monitoring. METHODS: The patient underwent a routine physical examination upon admission, followed by CT scans of the chest and abdomen, MRI of the brain, and bone marrow smear examination...
March 1, 2024: Alternative Therapies in Health and Medicine
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JOURNAL ARTICLE
Philippe Gélisse, Carlos Gallegos, Annacarmen Nilo, Greta Macorig, Pierre Genton, Arielle Crespel
Epilepsy with eyelid myoclonia (EM) or Jeavons syndrome (JS) is an epileptic syndrome related to the spectrum of genetic generalized epilepsies (GGE). We report two untreated children on which EEGs were performed several hours after a generalized tonic-clonic seizure (GTCS). These showed a unilateral, nearly continuous posterior slowing. This slow-wave activity was associated with contralateral epileptiform activity in one case, while in the second case, it was associated with an ipsilateral activity. However, in the latter child, a few months later an independent focus on the contralateral side was observed...
February 28, 2024: Clinical Neurophysiology
#30
JOURNAL ARTICLE
Yongqing Hou, Haishuo Xia, Tianbao He, Bohua Zhang, Guiping Qiu, Antao Chen
OBJECTIVE: Schizophrenia often occurs during youth, and psychosis risk syndrome occurs before the onset of psychosis. The aim of this study was to determine whether the visual event-related potential responses in youths with psychosis risk syndrome were defective in the presence of interference stimuli and associated with their clinical outcomes. METHODS: A total of 223 participants, including 122 patients with psychosis risk syndrome, 50 patients with emotional disorders, and 51 healthy control subjects, were assessed...
April 1, 2024: American Journal of Psychiatry
#31
REVIEW
Annio Posar, Paola Visconti
In the context of childhood epilepsy, the concept of continuous spike-waves during slow sleep (CSWS) includes several childhood-onset heterogeneous conditions that share electroencephalograms (EEGs) characterized by a high frequency of paroxysmal abnormalities during sleep, which have negative effects on the cognitive development and behavior of the child. These negative effects may have the characteristics of a clear regression or of a slowdown in development. Seizures are very often present, but not constantly...
January 28, 2024: Children
#32
JOURNAL ARTICLE
Yılmaz Yıldız, Didem Ardıçlı, Rahşan Göçmen, Dilek Yalnızoğlu, Meral Topçu, Turgay Coşkun, Ayşegül Tokatlı, Göknur Haliloğlu
OBJECTIVE: To evaluate clinical characteristics and long-term outcomes in patients with guanidinoacetate methyltransferase (GAMT) deficiency with a special emphasis on seizures and electroencephalography (EEG) findings. METHODS: We retrospectively analyzed the clinical and molecular characteristics, seizure types, EEG findings, neuroimaging features, clinical severity scores, and treatment outcomes in six patients diagnosed with GAMT deficiency. RESULTS: Median age at presentation and diagnosis were 11...
February 15, 2024: European Journal of Paediatric Neurology: EJPN
#33
JOURNAL ARTICLE
Paolo Di Bella, Anna Gaia Attardi, Ambra Butera, Arianna Mancini, Nunzia Calabrò, Elisa Giuseppa Lo Re, Giuseppe Trimarchi, Antonio Gennaro Nicotera, Gabriella Di Rosa, Daniela Lo Giudice
The post-COVID-19 condition is defined by the World Health Organization as the persistence of symptoms or development of new symptoms three months after the initial SARS-CoV-2 infection, lasting for at least two months without a clear explanation. Neuropsychiatric disorders associated with this condition include asthenia, memory and concentration problems, and sleep disturbances. Our study aims to investigate sleep patterns following SARS-CoV-2 infection using EEG findings and a sleep quality questionnaire completed by parents (Sleep Disturbance Scale for Children-SDSC)...
January 30, 2024: Journal of Personalized Medicine
#34
JOURNAL ARTICLE
Juliette F Langeslag, Wes Onland, Floris Groenendaal, Linda S de Vries, Anton H van Kaam, Timo R de Haan
OBJECTIVE: To investigate the association between the presence and severity of seizures in asphyxiated newborns and their neurodevelopmental outcome at ages two and five years. METHODS: Retrospective data analysis from a prospectively collected multicenter cohort of 186 term-born asphyxiated newborns undergoing therapeutic hypothermia (TH) in 11 centers in the Netherlands and Belgium. Seizures were diagnosed by amplitude-integrated electroencephalography (EEG) and raw EEG signal reading up to 48 hours after rewarming...
February 2, 2024: Pediatric Neurology
#35
JOURNAL ARTICLE
Natalia Juliá-Palacios, Mireia Olivella, Mariya Sigatullina Bondarenko, Salvador Ibáñez-Micó, Beatriz Muñoz-Cabello, Olga Alonso-Luengo, Víctor Soto-Insuga, Deyanira García-Navas, Laura Cuesta-Herraiz, Patricia Andreo-Lillo, Sergio Aguilera-Albesa, Antonio Hedrera-Fernández, Elena González Alguacil, Rocío Sánchez-Carpintero, Fernando Martín Del Valle, Erika Jiménez González, Lourdes Cean Cabrera, Ines Medina-Rivera, Marta Perez-Ordoñez, Roser Colomé, Laura Lopez, María Engracia Cazorla, Montserrat Fornaguera, Aida Ormazabal, Itziar Alonso-Colmenero, Katia Sofía Illescas, Sol Balsells-Mejía, Rosanna Mari-Vico, Maria Duffo Viñas, Gerarda Cappuccio, Gaetano Terrone, Roberta Romano, Filippo Manti, Mario Mastrangelo, Chiara Alfonsi, Bruna de Siqueira Barros, Mathilde Nizon, Cathrine Elisabeth Gjerulfsen, Valeria L Muro, Daniela Karall, Fiona Zeiner, Silvia Masnada, Irene Peterlongo, Alfonso Oyarzábal, Ana Santos-Gómez, Xavier Altafaj, Ángeles García-Cazorla
GRIN-related disorders are rare developmental encephalopathies with variable manifestations and limited therapeutic options. Here, we present the first non-randomized, open-label, single-arm trial (NCT04646447) designed to evaluate tolerability and efficacy of L-serine in children with GRIN genetic variants leading to loss-of-function. In this phase 2A trial, patients aged 2-18 years with GRIN loss-of-function pathogenic variants received L-serine for 52-weeks. Primary endpoints included safety and efficacy by measuring changes in the Vineland Adaptive Behavior Scales, Bayley Scales, age-appropriate Wechsler Scales, Gross Motor Function-88, Sleep Disturbance Scale for Children, Pediatric Quality of Life, Child Behavior Checklist and the Caregiver-Teacher Report Form following 12 months treatment...
February 21, 2024: Brain
#36
Shima Shekari, Farima Farsi, Farah Ashrafzadeh, Shima Imannezhad, Ahmad Sohrab Niazi, Samane Kamali
Mild encephalopathy with a reversible splenial lesion (MERS) is a rare phenomenon, which shows transient lesion in corpus callosum and causes temporary encephalopathy features. A disturbance of consciousness and abnormal and delirious behavior are the most significant neurological symptoms. A seven-year-old child with a history of fever and cough was admitted to our hospital due to sudden bilateral blindness. His physical examination showed confusion, fever, and delirious behavior. No sign of meningeal irritation or focal neurological deficit was observed...
February 2024: Clinical Case Reports
#37
JOURNAL ARTICLE
Mahmood Mohammadi, Reza Shervin Badv, Zahra Rezaei, Mahmoodreza Ashrafi, Fatemeh Naeemi
OBJECTIVES: Long-term video-EEG monitoring (LTM) is a new technique to assess and track fluctuations, classify seizures, identify epileptic syndromes, and determine the number of seizures and epilepsy-simulating disorders. The present study aims to evaluate the concordance of traditional EEG and LTM in assessing childhood epilepsy. MATERIALS & METHODS: This cross-sectional before-after study was performed on 120 children with epilepsy who were referred to the Epilepsy Monitoring Unit (EMU) at the Children's Medical Center between September 2021 and September 2022 and were monitored for at least eight hours in this unit...
2024: Iranian Journal of Child Neurology
#38
JOURNAL ARTICLE
Annalisa G V Hauck, Marianne van der Vaart, Eleri Adams, Luke Baxter, Aomesh Bhatt, Daniel Crankshaw, Amraj Dhami, Ria Evans Fry, Marina B O Freire, Caroline Hartley, Roshni C Mansfield, Simon Marchant, Vaneesha Monk, Fiona Moultrie, Mariska Peck, Shellie Robinson, Jean Yong, Ravi Poorun, Maria M Cobo, Rebeccah Slater
BACKGROUND: Touch interventions such as massage and skin-to-skin contact relieve neonatal pain. The Parental touch trial (Petal) aimed to assess whether parental stroking of their baby before a clinically required heel lance, at a speed of approximately 3 cm/s to optimally activate C-tactile nerve fibres, provides effective pain relief. METHODS: Petal is a multicentre, randomised, parallel-group interventional superiority trial conducted in the John Radcliffe Hospital (Oxford University Hospitals NHS Foundation Trust, Oxford, UK) and the Royal Devon and Exeter Hospital (Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK)...
February 16, 2024: Lancet Child & Adolescent Health
#39
JOURNAL ARTICLE
Hanna Westergren, Mikael Finder, Helena Marell-Hesla, Ronny Wickström
AIM: To conduct a systematic review of post-neonatal neurological outcomes and mortality following neonatal seizures with electroencephalographical verification. METHODS: The databases Medline, Embase and Web of Science were searched for eligible studies. All abstracts were screened in a blinded fashion between research team members and reports found eligible were obtained and screened in full text by two members each. From studies included, outcome results for post-neonatal epilepsy, cerebral palsy, intellectual disability, developmental delay, mortality during and after the neonatal period and composite outcomes were extracted...
February 12, 2024: European Journal of Paediatric Neurology: EJPN
#40
JOURNAL ARTICLE
Annalisa Saracino, Martina Totaro, Davide Politano, Valentina DE Giorgis, Simone Gana, Grazia Papalia, Anna Pichiecchio, Massimo Plumari, Elisa Rognone, Costanza Varesio, Simona Orcesi
PGAP2 gene has been known to be the cause of "hyperphosphatasia, mental retardation syndrome-3" (HPMRS3). To date, 14 pathogenic variants in PGAP2 have been identified as the cause of this syndrome in 24 patients described in single-case reports or small clinical series with pan-ethnic distribution. We aim to present a pediatric PGAP2 -mutated case, intending to further expand the clinical phenotype of the syndrome and to report our experience on a therapeutic approach to drug-resistant epilepsy.We present the clinical, neuroradiological, and genetic characterization of a Caucasian pediatric subject with biallelic pathogenic variants in the PGAP2 gene revealed by next generation sequencing analysis...
April 2024: Neuropediatrics
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