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https://www.readbyqxmd.com/read/29136149/pesticide-use-in-agriculture-and-parkinson-s-disease-in-the-agrican-cohort-study
#1
Camille Pouchieu, Clément Piel, Camille Carles, Anne Gruber, Catherine Helmer, Séverine Tual, Elisabeth Marcotullio, Pierre Lebailly, Isabelle Baldi
Background and Aim: Epidemiological studies have reported an increased risk of Parkinson's disease (PD) in farmers exposed to pesticides, but no clear conclusion can be drawn on the type of pesticide and duration of use associated with an effect. In the French agricultural cohort AGRICAN, we assessed associations between PD and pesticide use according to the types of livestock and crops grown, including exposure to some active ingredients with duration of use. Methods: Self-reported PD and history of lifetime exposure to 13 crops and 5 types of animals and pesticide use were collected at enrolment (2005-07) among 181 842 participants...
November 9, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29112783/toblerols-cyclopropanol-containing-modulators-of-methylobacterial-antibiosis-generated-by-an-unusual-polyketide-synthase
#2
Reiko Ueoka, Miriam Bortfeld-Miller, Brandon Isamu Morinaka, Julia Anne Vorholt, Jörn Piel
Trans-AT polyketide synthases (PKSs) are biosynthetically versatile enzymes that generate bioactive polyketides of high structural diversity. In this study, we detected in the genome of several bacteria a cryptic, unusual trans-AT PKS gene cluster that eluded automated PKS prediction. Genomic mining of one of these strains, the model methylotroph Methylobacterium extorquens AM1, revealed epoxide-cyclopropanol-containing polyketides named toblerols. The stereochemistry was determined by NMR, chemical derivatization, and the comparison of CD data with those of a synthesized model compound...
November 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29107441/real-life-experience-with-hydroxyurea-in-sickle-cell-disease-a-multicenter-study-in-a-cohort-of-patients-with-heterogeneous-descent
#3
Paolo Rigano, Lucia De Franceschi, Laura Sainati, Antonio Piga, Frédéric B Piel, Maria Domenica Cappellini, Carmelo Fidone, Nicoletta Masera, Giovanni Palazzi, Barbara Gianesin, Gian Luca Forni
We conducted the first nation-wide cohort study of sickle cell disease (SCD) in Italy, a Southern European country exposed to intense recent flux migration from endemic areas for SCD. We evaluate the impact of hydroxyurea on a total of 652 pediatric and adult patients from 33 Reference Centers for SCD (mean age 24.5±15years, 51.4% males). Hydroxyurea median treatment duration was 7years (range: <1year to 29years) at a mean therapeutic dose of 18±4.7mg/kg/day. Hydroxyurea was associated with a significant increase in mean total and fetal hemoglobin and a significant decrease in mean hemoglobin S, white blood and platelet counts, and lactate dehydrogenase levels...
October 9, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/29079589/lysosome-signaling-controls-the-migration-of-dendritic-cells
#4
Marine Bretou, Pablo J Sáez, Doriane Sanséau, Mathieu Maurin, Danielle Lankar, Melanie Chabaud, Carmine Spampanato, Odile Malbec, Lucie Barbier, Shmuel Muallem, Paolo Maiuri, Andrea Ballabio, Julie Helft, Matthieu Piel, Pablo Vargas, Ana-Maria Lennon-Duménil
Dendritic cells (DCs) patrol their environment by linking antigen acquisition by macropinocytosis to cell locomotion. DC activation upon bacterial sensing inhibits macropinocytosis and increases DC migration, thus promoting the arrival of DCs to lymph nodes for antigen presentation to T cells. The signaling events that trigger such changes are not fully understood. We show that lysosome signaling plays a critical role in this process. Upon bacterial sensing, lysosomal calcium is released by the ionic channel TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1), which activates the actin-based motor protein myosin II at the cell rear, promoting fast and directional migration...
October 27, 2017: Science Immunology
https://www.readbyqxmd.com/read/29037416/the-diet-of-open-habitat-chimpanzees-pan-troglodytes-schweinfurthii-in-the-issa-valley-western-tanzania
#5
Alex K Piel, Paolo Strampelli, Emily Greathead, R Adriana Hernandez-Aguilar, Jim Moore, Fiona A Stewart
Comparative data on the diets of extant primates inform hypotheses about hominin resource use. Historically, data describing chimpanzee diets stem primarily from forest-dwelling communities, and we lack comparative data from chimpanzees that live in mosaic habitats that more closely resemble those reconstructed for Plio-Pleistocene hominins. We present data on the diet of a partially-habituated community of open habitat chimpanzees (Pan troglodytes schweinfurthii) from the Issa valley, western Tanzania, collected over a four-year period...
November 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29037414/chimpanzee-vertebrate-consumption-savanna-and-forest-chimpanzees-compared
#6
Jim Moore, Jessica Black, R Adriana Hernandez-Aguilar, Gen'ichi Idani, Alex Piel, Fiona Stewart
There is broad consensus among paleoanthropologists that meat-eating played a key role in the evolution of Homo, but the details of where, when, and why are hotly debated. It has been argued that increased faunivory was causally connected with hominin adaptation to open, savanna habitats. If savanna-dwelling chimpanzees eat meat more frequently than do forest chimpanzees, it would support the notion that open, dry, seasonal habitats promote hunting or scavenging by hominoids. Here we present observational and fecal analysis data on vertebrate consumption from several localities within the dry, open Ugalla region of Tanzania...
November 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29019346/occupational-exposure-to-pesticides-development-of-a-job-exposure-matrix-for-use-in-population-based-studies-pestipop
#7
Camille Carles, Ghislaine Bouvier, Yolande Esquirol, Camille Pouchieu, Lucile Migault, Clément Piel, Pascale Fabbro-Peray, Séverine Tual, Pierre Lebailly, Isabelle Baldi
Occupational exposure to pesticides concerns a wide population of workers not only in agriculture. The reliability of self-reported information on pesticide use is questionable because of the diversity of use. The PESTIPOP job-exposure matrix has been designed to assess pesticide occupational exposure in the general population. The matrix is composed of two axes: the first axis corresponding to jobs (combinations of occupations and industries) and the second one to pesticide exposure. The estimated exposure metric is the probability of exposure coupled with a reliability assessment (low, medium or high)...
October 11, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29018473/qtl-analyses-in-multiple-populations-employed-for-the-fine-mapping-and-identification-of-candidate-genes-at-a-locus-affecting-sugar-accumulation-in-melon-cucumis-melo-l
#8
Jason M Argyris, Aurora Díaz, Valentino Ruggieri, Marta Fernández, Torben Jahrmann, Yves Gibon, Belén Picó, Ana M Martín-Hernández, Antonio J Monforte, Jordi Garcia-Mas
Sugar content is the major determinant of both fruit quality and consumer acceptance in melon (Cucumis melo L), and is a primary target for crop improvement. Near-isogenic lines (NILs) derived from the intraspecific cross between a "Piel de Sapo" (PS) type and the exotic cultivar "Songwhan Charmi" (SC), and several populations generated from the cross of PS × Ames 24294 ("Trigonus"), a wild melon, were used to identify QTL related to sugar and organic acid composition. Seventy-eight QTL were detected across several locations and different years, with three important clusters related to sugar content located on chromosomes 4, 5, and 7...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28980083/adenovirus-infection-in-savanna-chimpanzees-pan-troglodytes-schweinfurthii-in-the-issa-valley-tanzania
#9
Eva Dadáková, Kristýna Brožová, Alex K Piel, Fiona A Stewart, David Modrý, Vladimír Celer, Kristýna Hrazdilová
Adenoviruses are a widespread cause of diverse human infections with recently confirmed zoonotic roots in African great apes. We focused on savanna-dwelling chimpanzees in the Issa Valley (Tanzania), which differ from those from forested sites in many aspects of behavior and ecology. PCR targeting the DNA polymerase gene detected AdV in 36.7% (69/188) of fecal samples. We detected five groups of strains belonging to the species Human mastadenovirus E and two distinct groups within the species Human mastadenovirus C based on partial hexon sequence...
October 4, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28882762/estimation-of-the-diagnostic-performance-of-two-elisas-to-detect-pcv2-antibodies-in-pig-sera-using-a-bayesian-method
#10
C Fablet, N Rose, C Bernard, I Messager, Y Piel, B Grasland
This study was designed to assess the diagnostic characteristics of two PCV2 ELISAs without a gold standard. Four hundred and sixty-five serum samples from finishing pigs (25 herds) not vaccinated against PCV2 were used. Samples were tested by two ELISAs: an in-house ELISA (I-ELISA) and the commercial SERELISA(®)PCV2 Ab Mono Blocking kit (S-ELISA). A ROC curve was used to assess the S-ELISA's optimal threshold by taking the I-ELISA as a reference and using the cut-off previously determined by comparison to an cccmonolayer assay (IPMA)...
September 5, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28841998/quantitation-and-biospecific-identification-of-virus-like-particles-of-human-papillomavirus-by-capillary-electrophoresis
#11
Virginie Bettonville, Jérôme T J Nicol, Tania Furst, Nicolas Thelen, Géraldine Piel, Marc Thiry, Marianne Fillet, Nathalie Jacobs, Anne-Catherine Servais
Capillary electrophoresis (CE) for HPV-VLP quantitation is a very interesting alternative technique compared to those currently used in viral analysis, such as SDS-PAGE, Western blot or protein assay that are destructive and semi-quantitative or non specific. In this study, the quantitative performance of the CE method was evaluated. A main issue in virus quantitation is the absence of reference material. Therefore, the concentration of a HPV16-VLP sample produced in the laboratory was determined using ELISA with Gardasil(®), after adjuvant dissolution, as reference material and conformational H16...
December 1, 2017: Talanta
https://www.readbyqxmd.com/read/28840383/comprehensive-echocardiographic-assessment-of-biventricular-function-in-the-rabbit-animal-model-in-cardiovascular-research-feasibility-and-normal-values
#12
Sara Roldan Ramos, Guido Pieles, Wei Hui, Ryo Ishii, Cameron Slorach, Mark K Friedberg
Quantification of cardiac structure and function is central in cardiovascular research. Rabbits are valuable research models of cardiovascular human disease; however, there is little normal data available. The aim of this study was to investigate feasibility and provide normal values for comprehensive echocardiographic assessment of biventricular function in rabbits. New Zealand white rabbits underwent trans-thoracic echocardiography using a general electric (GE) Vivid 7/E9 system with a 10 MHz transducer, under light sedation, to evaluate biventricular function and dimensions...
August 24, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28837904/residential-proximity-to-agricultural-land-and-risk-of-brain-tumor-in-the-general-population
#13
Camille Carles, Ghislaine Bouvier, Yolande Esquirol, Clément Piel, Lucile Migault, Camille Pouchieu, Pascale Fabbro-Peray, Pierre Lebailly, Isabelle Baldi
The effect of pesticides on human health is still controversial, particularly as regards long-term health effects like cancer. The literature does suggest, however, that they could be involved in the occurrence of brain tumors, although the results concerning residential exposure are scarce. Our objective was to investigate the association between residential proximity to agricultural pesticides and brain tumors among adults in France by using a geographical information system. CERENAT is a population-based case-control study carried out in France in 2004-2006...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28763511/correction-the-malagarasi-river-does-not-form-an-absolute-barrier-to-chimpanzee-movement-in-western-tanzania
#14
Alex K Piel, Fiona A Stewart, Lilian Pintea, Yingying Li, Miguel A Ramirez, Dorothy E Loy, Patricia A Crystal, Gerald H Learn, Leslie A Knapp, Paul M Sharp, Beatrice H Hahn
[This corrects the article DOI: 10.1371/journal.pone.0058965.].
2017: PloS One
https://www.readbyqxmd.com/read/28763317/rocuronium-is-more-hepatotoxic-than-succinylcholine-in-vitro
#15
Martin Sauer, Ines Piel, Cristof Haubner, Georg Richter, Miriam Mann, Gabriele Nöldge-Schomburg, Thomas Mencke
BACKGROUND: The development of liver failure is a major problem in critically ill patients. The hepatotoxicity of many drugs, as one important reason for liver failure, is poorly screened for in human models. Rocuronium and succinylcholine are neuromuscular blocking agents used for tracheal intubation and for rapid-sequence induction. OBJECTIVE: We used an in-vitro test with a permanent cell line and compared rocuronium and succinylcholine for hepatotoxicity. DESIGN: In-vitro study...
September 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28734287/on-the-thermophysical-and-transport-properties-of-3-he-and-4-he-a-bubble-interaction-potential-versus-state-of-the-art
#16
Michael Chrysos, Henri Piel
Three keynote thermophysical and transport properties of (3)He and (4)He, namely, the second virial coefficient, the shear viscosity, and the thermal conductivity, are reported for the "extended Dirac bubble potential" (EDbp), a novel model for He-He [M. Chrysos, J. Chem. Phys. 146, 024106 (2017)]. Comparisons with the experiment as well as with potentials with a proven track record and with the oversimplified Dbp are being made in the range 0.1-500 K to analyze the performance of the EDbp, which is shown here to emerge as a promising analytic model for He-He...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28723338/sickle-cell-disease
#17
LETTER
Frédéric B Piel, Martin H Steinberg, David C Rees
New England Journal of Medicine, Volume 377, Issue 3, Page 302-305, July 2017.
July 20, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28710536/resistance-to-tomato-leaf-curl-new-delhi-virus-in-melon-is-controlled-by-a-major-qtl-located-in-chromosome-11
#18
Cristina Sáez, Cristina Esteras, Cecilia Martínez, María Ferriol, Narinder P S Dhillon, Carmelo López, Belén Picó
Identification of three genomic regions and underlying candidate genes controlling the high level of resistance to ToLCNDV derived from a wild melon. SNP markers appropriated for MAS management of resistance. Tomato leaf curl New Delhi virus (ToLCNDV) is a bipartite begomovirus that severely affects melon crop (Cucumis melo) in the main production areas of Spain since 2012. In this work, we evaluated the degree of resistance of four accessions (two belonging to the subsp. agrestis var. momordica and two to the wild agrestis group) and their corresponding hybrids with a susceptible commercial melon belonging to the subsp...
July 14, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28685816/central-nervous-system-tumors-and-agricultural-exposures-in-the-prospective-cohort-agrican
#19
Clément Piel, Camille Pouchieu, Séverine Tual, Lucile Migault, Clémentine Lemarchand, Camille Carles, Mathilde Boulanger, Anne Gruber, Virginie Rondeau, Elisabeth Marcotullio, Pierre Lebailly, Isabelle Baldi
Studies in farmers suggest a possible role of pesticides in the occurrence of Central Nervous System (CNS) tumors but scientific evidence is still insufficient. Using data from the French prospective agricultural cohort AGRICAN (Agriculture & Cancer), we investigated the associations between exposure of farmers and pesticide users to various kinds of crops and animal farming and the incidence of CNS tumors, overall and by subtypes. Over the 2005-2007, 181,842 participants completed the enrollment questionnaire that collected a complete job calendar with lifetime history of farming types...
November 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28641118/mechanisms-for-fast-cell-migration-in-complex-environments
#20
REVIEW
Pablo Vargas, Lucie Barbier, Pablo José Sáez, Matthieu Piel
Cell migration depends on a combination of the cell's intrinsic capacity to move and the proper interpretation of external cues. This multistep process enables leukocytes to travel long distances in organs in just a few hours. This fast migration is partly due to the leukocytes' high level of plasticity, which helps them to adapt to a changing environment. Here, we review recent progress in understanding the mechanisms used by leukocytes to move rapidly and efficiently in intricate anatomical landscapes. We shall focus on specific cytoskeletal rearrangements used by neutrophils and dendritic cells to migrate within confined environments...
June 19, 2017: Current Opinion in Cell Biology
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