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https://www.readbyqxmd.com/read/27909222/associations-between-environmental-factors-and-hospital-admissions-for-sickle-cell-disease
#1
Frédéric B Piel, Sanjay Tewari, Valentine Brousse, Antonis Analitis, Anna Font, Stephan Menzel, Subarna Chakravorty, Swee Lay Thein, Baba Inusa, Paul Telfer, Marianne de Montalembert, Gary W Fuller, Klea Katsouyanni, David C Rees
Sickle cell disease (SCD) is an increasing global health burden. This inherited disease is characterised by a remarkable phenotypic heterogeneity, which can only partly be explained by genetic factors. Environmental factors are likely to play an important role but studies of their impact on disease severity are limited and their results are often inconsistent. This study investigated associations between a range of environmental factors and hospital admissions of young patients with SCD in London and in Paris between 2008 and 2012...
December 1, 2016: Haematologica
https://www.readbyqxmd.com/read/27897311/the-evolutionary-and-clinical-implications-of-the-uneven-distribution-of-the-frequency-of-the-inherited-haemoglobin-variants-over-short-geographical-distances
#2
Anuja Premawardhena, Angela Allen, Fred Piel, Chris Fisher, Laxman Perera, Rexan Rodrigo, Gayan Goonathilaka, Lebbe Ramees, Tim Peto, Nancy Olivieri, David Weatherall
Studies of the frequency of heterozygous carriers for common inherited diseases of haemoglobin in over 7500 adolescent children in 25 districts in Sri Lanka have disclosed a highly significant variation over very short geographical distances. A further analysis of these findings, including their relationship to the past frequency and distribution of malaria, climatic variation, altitude, ethnic origin and consanguinity rates, have provided evidence regarding the evolutionary basis for the variable distribution of these conditions over short distances...
November 29, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27883308/response-to-ethical-and-clinical-dilemmas-in-using-psychotropic-medications-during-pregnancy
#3
Jennifer Piel, Suzanne B Murray, Carmen Antonela Croicu
No abstract text is available yet for this article.
November 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/27878218/nursing-care-missed-in-patients-at-risk-of-or-having-pressure-ulcers
#4
Jonathan Hermayn Hernández Valles, María Guadalupe Moreno Monsiváis, Ma Guadalupe Interial Guzmán, Leticia Vázquez Arreola
Objective: to determine the nursing care missed as perceived by the nursing staff and its relation with the nursing care missed identified in the assessment of patients at risk of or having pressur ulcers. Method: descriptive correlation study. The participants were 161 nurses and 483 patients from a public hospital. The MISSCARE survey was used in combination with a Nursing Care Assessment Form for Patients at Risk of or having pressure ulcers. For the analysis, descriptive and inferential statistics were used...
November 21, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27837454/diabetes-and-hypertension-in-marshallese-adults-results-from-faith-based-health-screenings
#5
Pearl Anna McElfish, Brett Rowland, Christopher R Long, Jonell Hudson, Michelle Piel, Bill Buron, Sheldon Riklon, Williamina Ioanna Bing, T Scott Warmack
BACKGROUND: The Pacific Islander population in the USA is growing rapidly. However, research on Pacific Islanders in the USA is limited, or sometimes misleading due to aggregation with Asian Americans. This project seeks to add to the dearth of health literature by conducting a health assessment of Marshallese in northwest Arkansas. METHODS: Using a community-based participatory research approach, nine health screening events were conducted at local Marshallese churches...
November 11, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27790989/reduced-anthropogenic-aerosol-radiative-forcing-caused-by-biogenic-new-particle-formation
#6
Hamish Gordon, Kamalika Sengupta, Alexandru Rap, Jonathan Duplissy, Carla Frege, Christina Williamson, Martin Heinritzi, Mario Simon, Chao Yan, João Almeida, Jasmin Tröstl, Tuomo Nieminen, Ismael K Ortega, Robert Wagner, Eimear M Dunne, Alexey Adamov, Antonio Amorim, Anne-Kathrin Bernhammer, Federico Bianchi, Martin Breitenlechner, Sophia Brilke, Xuemeng Chen, Jill S Craven, Antonio Dias, Sebastian Ehrhart, Lukas Fischer, Richard C Flagan, Alessandro Franchin, Claudia Fuchs, Roberto Guida, Jani Hakala, Christopher R Hoyle, Tuija Jokinen, Heikki Junninen, Juha Kangasluoma, Jaeseok Kim, Jasper Kirkby, Manuel Krapf, Andreas Kürten, Ari Laaksonen, Katrianne Lehtipalo, Vladimir Makhmutov, Serge Mathot, Ugo Molteni, Sarah A Monks, Antti Onnela, Otso Peräkylä, Felix Piel, Tuukka Petäjä, Arnaud P Praplan, Kirsty J Pringle, Nigel A D Richards, Matti P Rissanen, Linda Rondo, Nina Sarnela, Siegfried Schobesberger, Catherine E Scott, John H Seinfeld, Sangeeta Sharma, Mikko Sipilä, Gerhard Steiner, Yuri Stozhkov, Frank Stratmann, Antonio Tomé, Annele Virtanen, Alexander Lucas Vogel, Andrea C Wagner, Paul E Wagner, Ernest Weingartner, Daniela Wimmer, Paul M Winkler, Penglin Ye, Xuan Zhang, Armin Hansel, Josef Dommen, Neil M Donahue, Douglas R Worsnop, Urs Baltensperger, Markku Kulmala, Joachim Curtius, Kenneth S Carslaw
The magnitude of aerosol radiative forcing caused by anthropogenic emissions depends on the baseline state of the atmosphere under pristine preindustrial conditions. Measurements show that particle formation in atmospheric conditions can occur solely from biogenic vapors. Here, we evaluate the potential effect of this source of particles on preindustrial cloud condensation nuclei (CCN) concentrations and aerosol-cloud radiative forcing over the industrial period. Model simulations show that the pure biogenic particle formation mechanism has a much larger relative effect on CCN concentrations in the preindustrial atmosphere than in the present atmosphere because of the lower aerosol concentrations...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27769952/changes-in-energy-metabolism-due-to-acute-rotenone-induced-mitochondrial-complex-i-dysfunction-an-in-vivo-large-animal-model
#7
Michael Karlsson, Johannes K Ehinger, Sarah Piel, Fredrik Sjövall, Johanna Henriksnäs, Urban Höglund, Magnus J Hansson, Eskil Elmér
Metabolic crisis is a clinical condition primarily affecting patients with inherent mitochondrial dysfunction in situations of augmented energy demand. To model this, ten pigs received an infusion of rotenone, a mitochondrial complex I inhibitor, or vehicle. Clinical parameters, blood gases, continuous indirect calorimetry, in vivo muscle oxygen tension, ex vivo mitochondrial respiration and metabolomics were assessed. Rotenone induced a progressive increase in blood lactate which was paralleled by an increase in oxygen tension in venous blood and skeletal muscle...
November 2016: Mitochondrion
https://www.readbyqxmd.com/read/27765071/circadian-rhythms-have-significant-effects-on-leaf-to-canopy-scale-gas-exchange-under-field-conditions
#8
Víctor Resco de Dios, Arthur Gessler, Juan Pedro Ferrio, Josu G Alday, Michael Bahn, Jorge Del Castillo, Sébastien Devidal, Sonia García-Muñoz, Zachary Kayler, Damien Landais, Paula Martín-Gómez, Alexandru Milcu, Clément Piel, Karin Pirhofer-Walzl, Olivier Ravel, Serajis Salekin, David T Tissue, Mark G Tjoelker, Jordi Voltas, Jacques Roy
BACKGROUND: Molecular clocks drive oscillations in leaf photosynthesis, stomatal conductance, and other cell and leaf-level processes over ~24 h under controlled laboratory conditions. The influence of such circadian regulation over whole-canopy fluxes remains uncertain; diurnal CO2 and H2O vapor flux dynamics in the field are currently interpreted as resulting almost exclusively from direct physiological responses to variations in light, temperature and other environmental factors. We tested whether circadian regulation would affect plant and canopy gas exchange at the Montpellier European Ecotron...
October 20, 2016: GigaScience
https://www.readbyqxmd.com/read/27744294/a-novel-method-to-study-contact-inhibition-of-locomotion-using-micropatterned-substrates
#9
Elena Scarpa, Alice Roycroft, Eric Theveneau, Emmanuel Terriac, Matthieu Piel, Roberto Mayor
No abstract text is available yet for this article.
October 15, 2016: Biology Open
https://www.readbyqxmd.com/read/27693898/effendys-fentanyl-buccal-tablet-for-the-relief-of-episodic-breathlessness-in-patients-with-advanced-cancer-a-multicenter-open-label-randomized-morphine-controlled-crossover-phase-ii-trial
#10
Steffen T Simon, Marianne Kloke, Bernd Alt-Epping, Jan Gärtner, Martin Hellmich, Rebecca Hein, Maren Piel, Oliver A Cornely, Friedemann Nauck, Raymond Voltz
CONTEXT: Episodic breathlessness is a frequent and burdensome symptom in cancer patients but pharmacological treatment is limited. OBJECTIVES: To determine time to onset, efficacy, feasibility and safety of transmucosal fentanyl in comparison to immediate-release morphine (IRM) for the relief of episodic breathlessness. METHODS: Phase II, investigator initiated, multicenter, open-label, randomized, morphine-controlled, crossover trial with open-label titration of fentanyl buccal tablet (FBT) in inpatients with incurable cancer...
September 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27651369/high-g-force-rollercoaster-rides-induce-sinus-tachycardia-but-no-cardiac-arrhythmias-in-healthy-children
#11
Guido E Pieles, Victoria Husk, Teresa Blackwell, Deirdre Wilson, Simon M Collin, Craig A Williams, A Graham Stuart
Theme park operators and medical professionals advise children with heart conditions against using rollercoaster rides, but these recommendations are not evidence-based. The underlying assumption is that the combination of adrenergic stimulation through stress and acceleration might trigger arrhythmias in susceptible individuals. We conducted a cross-sectional observational study to assess heart rate and rhythm in healthy children during commercial rollercoaster rides. Twenty healthy children (9 male) aged 11-15 (mean 13...
September 21, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27644860/informed-consent-in-right-to-try-cases
#12
Jennifer Piel
No abstract text is available yet for this article.
September 2016: Journal of the American Academy of Psychiatry and the Law
https://www.readbyqxmd.com/read/27638826/-pulmonary-granulomatous-diseases-and-pulmonary-manifestations-of-systemic-granulomatous-disease-including-tuberculosis-and-nontuberculous-mycobacteriosis
#13
S Piel, M Kreuter, F Herth, H-U Kauczor, C-P Heußel
CLINICAL/METHODICAL ISSUE: Granulomas as signs of specific inflammation of the lungs are found in various diseases with pulmonary manifestations and represent an important imaging finding. STANDARD RADIOLOGICAL METHODS: The standard imaging modality for the work-up of granulomatous diseases of the lungs is most often thin-slice computed tomography (CT). There are a few instances, e. g. tuberculosis, sarcoidosis and silicosis, where a chest radiograph still plays an important role...
October 2016: Der Radiologe
https://www.readbyqxmd.com/read/27599036/a-novel-role-for-progesterone-receptor-membrane-component-1-pgrmc1-a-partner-and-regulator-of-ferrochelatase
#14
Robert B Piel, Mesafint T Shiferaw, Ajay A Vashisht, Jason R Marcero, Jeremy L Praissman, John D Phillips, James A Wohlschlegel, Amy E Medlock
Heme is an iron-containing cofactor essential for multiple cellular processes and fundamental activities such as oxygen transport. To better understand the means by which heme synthesis is regulated during erythropoiesis, affinity purification coupled with mass spectrometry (MS) was performed to identify putative protein partners interacting with ferrochelatase (FECH), the terminal enzyme in the heme biosynthetic pathway. Both progesterone receptor membrane component 1 (PGRMC1) and progesterone receptor membrane component 2 (PGRMC2) were identified in these experiments...
September 20, 2016: Biochemistry
https://www.readbyqxmd.com/read/27593989/pegylation-of-lipoplexes-the-right-balance-between-cytotoxicity-and-sirna-effectiveness
#15
Anna Lechanteur, Tania Furst, Brigitte Evrard, Philippe Delvenne, Pascale Hubert, Géraldine Piel
The delivery of small interfering RNA (siRNA) is an attractive therapeutic approach to treat several pathologies, such as viral infections or cancers. However, the stability and the efficacy of these biotherapies are still a major obstacle to their use. Cationic liposomes (DOTAP/Chol/DOPE 1/0.75/0.5M ratio) have been complexed to siRNA (lipoplexes) in order to be administrated by the vaginal route, in the context of HPV16 induced cervical preneoplastic lesions. To overcome the constraint of the cervico-vaginal mucus, PEGylation is required to allow the diffusion of lipoplexes through it...
October 10, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27584723/a-lanthipeptide-like-n-terminal-leader-region-guides-peptide-epimerization-by-radical-sam-epimerases-implications-for-ripp-evolution
#16
Sebastian W Fuchs, Gerald Lackner, Brandon I Morinaka, Yohei Morishita, Teigo Asai, Sereina Riniker, Jörn Piel
Ribosomally synthesized and posttranslationally modified peptide natural products (RiPPs) exhibit diverse structures and bioactivities and are classified into distinct biosynthetic families. A recently reported family is the proteusins, with the prototype members polytheonamides being generated by almost 50 maturation steps, including introduction of d-residues at multiple positions by an unusual radical SAM epimerase. A region in the protein-like N-terminal leader of proteusin precursors is identified that is crucial for epimerization...
September 26, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27561616/international-relations-at-universities-of-applied-sciences
#17
Roger Marti, Michal Dabros, Uwe Pieles, Urban Frey, Achim Ecker
An overview of international relations at the Universities of Applied Sciences in Switzerland is presented.
2016: Chimia
https://www.readbyqxmd.com/read/27543045/a-comparative-molecular-survey-of-malaria-prevalence-among-eastern-chimpanzee-populations-in-issa-valley-tanzania-and-kalinzu-uganda
#18
Mwanahamisi I Mapua, Klára J Petrželková, Jade Burgunder, Eva Dadáková, Kristýna Brožová, Kristýna Hrazdilová, Fiona A Stewart, Alex K Piel, Peter Vallo, Hans-Peter Fuehrer, Chie Hashimoto, David Modrý, Moneeb A Qablan
BACKGROUND: Habitat types can affect vector and pathogen distribution and transmission dynamics. The prevalence and genetic diversity of Plasmodium spp. in two eastern chimpanzee populations-Kalinzu Forest Reserve, Uganda and Issa Valley, Tanzania-inhabiting different habitat types was investigated. As a follow up study the effect of host sex and age on infections patterns in Kalinzu Forest Reserve chimpanzees was determined. METHODS: Molecular methods were employed to detect Plasmodium DNA from faecal samples collected from savanna-woodland (Issa Valley) and forest (Kalinzu Forest Reserve) chimpanzee populations...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27528073/rapid-and-sensitive-quantitation-of-heme-in-hemoglobinized-cells
#19
Jason R Marcero, Robert B Piel Iii, Joseph S Burch, Harry A Dailey
Rapid and accurate heme quantitation in the research lab has become more desirable as the crucial role that intracellular hemoproteins play in metabolism continues to emerge. Here, the time-honored approaches of pyridine hemochromogen and fluorescence heme assays are compared with direct absorbance-based technologies using the CLARiTY spectrophotometer. All samples tested with these methods were rich in hemoglobin-associated heme, including buffered hemoglobin standards, whole blood from mice, and murine erythroleukemia (MEL) and K562 cells...
2016: BioTechniques
https://www.readbyqxmd.com/read/27508912/newborns-temperature-submitted-to-radiant-heat-and-to-the-top-maternal-device-at-birth
#20
Rosemeire Sartori de Albuquerque, Corintio Mariani, Ana Aparecida Sanches Bersusa, Vanessa Macedo Dias, Maria Izabel Mota da Silva
OBJECTIVE: to compare the axillar temperatures of newborns that are put immediately after birth in skin-to-skin contact under the Top Maternal device, as compared to those in a radiant heat crib. METHODS: comparatives observational study of the case-control type about temperature of 60 babies born at the Obstetric Center and Normal Delivery Center of a public hospital of the municipality of Sao Paulo, being them: 29 receiving assistance in heated crib and 31 in skin-to skin contact, shielded by a cotton tissue placed on mother's thorax, called Top Maternal...
August 8, 2016: Revista Latino-americana de Enfermagem
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