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https://www.readbyqxmd.com/read/28423290/sickle-cell-disease
#1
Frédéric B Piel, Martin H Steinberg, David C Rees
No abstract text is available yet for this article.
April 20, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28392155/-positional-paroxysmal-abdominal-pain
#2
M-L Piel-Julian, G Moulis, N Doumerc, P Seguin, L Astudillo, G Pugnet, L Sailler
No abstract text is available yet for this article.
April 6, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28391123/aminomethylphosphonic-acid-ampa-in-natural-waters-its-sources-behavior-and-environmental-fate
#3
REVIEW
Alexis Grandcoin, Stéphanie Piel, Estelle Baurès
The widely occurring degradation product aminomethylphosphonic acid (AMPA) is a result of glyphosate and amino-polyphosphonate degradation. Massive use of the parent compounds leads to the ubiquity of AMPA in the environment, and particularly in water. The purpose of this review is to summarize and discuss current insights into AMPA formation, transport, persistence and toxicity. In agricultural soils, AMPA is concentrated in the topsoil, and degrades slowly in most soils. It can reach shallow groundwater, but rarely managed to enter deep groundwater...
March 27, 2017: Water Research
https://www.readbyqxmd.com/read/28371720/whole-blood-microsampling-for-the-quantitation-of-estetrol-without-derivatization-by-liquid-chromatography-tandem-mass-spectrometry
#4
Gwenaël Nys, Anne Gallez, Miranda G M Kok, Gaël Cobraiville, Anne-Catherine Servais, Géraldine Piel, Christel Pequeux, Marianne Fillet
Quantitative bioanalysis and especially pharmacokinetic studies are challenging since only low volumes of biological material are available and low concentrations (ng/ml) are often expected. In this context, volumetric absorptive microsampling (VAMS) devices were developed to accurately collect 10 or 20μl of whole blood from tested subjects. In this study, we present the development and validation of ultra-high performance liquid chromatography coupled to tandem mass spectrometry method after VAMS sampling for the quantitation of estetrol (E4), a potentially new medicine for hormone replacement, contraception and osteoporosis therapies...
March 27, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28370791/cyanobacterial-ent-sterol-like-natural-products-from-a-deviated-ubiquinone-pathway
#5
Philipp Moosmann, Reiko Ueoka, Laura Grauso, Alfonso Mangoni, Brandon I Morinaka, Muriel Gugger, Jörn Piel
Natural products from marine animals show high potential for the development of new medicines, but drug development based on these compounds is commonly hampered by their low natural abundance. Since many of these metabolites are suspected or known to be produced by uncultivated bacterial symbionts, the rapidly growing diversity of sequenced prokaryotic genomes offers the opportunity to identify alternative, culturable sources of natural products computationally. In this work, we investigated the potential of using this sequenced resource to facilitate the production of meroterpenoid-like compounds related to those from marine sources...
March 30, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28370685/non-invasive-ethylene-quantification-in-attached-fruit-headspace-at-1-ppb-by-gas-chromatography-mass-spectrometry
#6
Lara Pereira, Marta Pujol, Jordi Garcia-Mas, Michael A Phillips
Ethylene is a gaseous plant hormone involved in defense, adaptations to environmental stress, and fruit ripening. Its relevance to the latter makes its detection highly useful to physiologists interested in ripening onset. Produced as a sharp peak during the respiratory burst, ethylene is biologically active at tens of nL·L(-1) . Reliable quantification at such concentrations generally requires specialized instrumentation. Here we present a rapid, high sensitivity method for detecting ethylene in attached fruit using a conventional gas chromatography - mass spectrometry (GC-MS) system and in situ headspace collection chambers...
March 28, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28363973/electrical-and-structural-adaptations-of-the-paediatric-athlete-s-heart-a-systematic-review-with-meta-analysis
#7
REVIEW
Gavin McClean, Nathan R Riding, Clare L Ardern, Abdulaziz Farooq, Guido E Pieles, Victoria Watt, Carmen Adamuz, Keith P George, David Oxborough, Mathew G Wilson
AIM: To describe the electrocardiographic (ECG) and echocardiographic manifestations of the paediatric athlete's heart, and examine the impact of age, race and sex on cardiac remodelling responses to competitive sport. DESIGN: Systematic review with meta-analysis. DATA SOURCES: Six electronic databases were searched to May 2016: MEDLINE, PubMed, EMBASE, Web of Science, CINAHL and SPORTDiscus. INCLUSION CRITERIA: (1) Male and/or female competitive athletes, (2) participants aged 6-18 years, (3) original research article published in English language...
March 31, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28350964/promoting-vaginal-distribution-of-e7-and-mcl-1-sirna-silencing-nanoparticles-for-cervical-cancer-treatment
#8
Anna Lechanteur, Tania Furst, Brigitte Evrard, Philippe Delvenne, Geraldine Piel, Pascale Hubert
There is an urgent need to develop a less aggressive and more effective treatment against cervical lesions induced by different high-risk human papillomavirus (HR-HPV). We investigated the potential of a cocktail of small interfering RNA (siRNA) directed against the oncoprotein E6 (E6), the oncoprotein E7 (E7) and/or the anti-apoptotic protein MCL-1 (MCL-1). The combination of siRNA anti-E7 and anti-MCL-1 demonstrated high efficacy on multiple HPV16 and HPV18 cell lines and no effects on healthy keratinocytes...
March 28, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28346861/biomimetic-remineralization-of-carious-lesions-by-self-assembling-peptide
#9
L Kind, S Stevanovic, S Wuttig, S Wimberger, J Hofer, B Müller, U Pieles
Caries is the most common disease in the world. Great efforts have been undertaken for prevention and to identify a regenerative treatment solution for dental caries. Self-assembling β-sheet forming peptides have previously shown to form 3-dimensional fiber networks supporting tissue regeneration. In particular, the self-assembling peptide P11-4 has shown potential in the treatment and prevention of dental caries. It has previously been shown that application of monomeric P11-4 solution to early carious lesions can increase net mineral gain by forming de novo hydroxyapatite crystals...
March 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28338684/seven-enzymes-create-extraordinary-molecular-complexity-in-an-uncultivated-bacterium
#10
Michael F Freeman, Maximilian J Helf, Agneya Bhushan, Brandon I Morinaka, Jörn Piel
Uncultivated bacteria represent a massive resource of new enzymes and bioactive metabolites, but such bacteria remain functionally enigmatic. Polytheonamides are potent peptide cytotoxins produced by uncultivated bacteria that exist as symbionts in a marine sponge. Outside glycobiology, polytheonamides represent the most heavily post-translationally modified biomolecules that are derived from amino acids. The biosynthesis of polytheonamides involves up to 50 site-specific modifications to create a membrane-spanning β-helical structure...
April 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28335663/universal-and-particular-in-morphological-processing-evidence-from-hebrew
#11
Yael Farhy, João Veríssimo, Harald Clahsen
Do properties of individual languages shape the mechanisms by which they are processed? By virtue of their non-concatenative morphological structure, the recognition of complex words in Semitic languages has been argued to rely strongly on morphological structure and decomposition into root and pattern constituents. Here, we report results from a masked priming experiment in Hebrew in which we contrasted verb forms belonging to two morphological classes, Paal and Piel, which display similar properties, but crucially differ on whether they are extended to novel verbs...
March 24, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28329500/lesi%C3%A3-n-cribiforme-en-la-cara-de-un-var%C3%A3-n-de-44-a%C3%A3-os-de-edad
#12
Romina Rodriguez-Lojo, Iria Castiñeiras, Olga Robles, Mercedes Otero, Yolanda Juarez, Mercedes Lueiro, Maria-Luisa Fernandez-Diaz
El acantoma de la vaina pilosa es un tumor benignode piel muy poco frecuente. Suele presentarse comouna pápula asintomática, con un orificio central y lalocalización más frecuente es la cara. Presentamos unnuevo caso de acantoma de vaina pilosa, apoartandoimagen dermatoscópica del tumor.
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28290537/compact-silicon-multimode-waveguide-spectrometer-with-enhanced-bandwidth
#13
Molly Piels, Darko Zibar
Compact, broadband, and high-resolution spectrometers are appealing for sensing applications, but difficult to fabricate. Here we show using calibration data a spectrometer based on a multimode waveguide with 2 GHz resolution, 250 GHz bandwidth, and a 1.6 mm × 2.1 mm footprint. Typically, such spectrometers have a bandwidth limited by the number of modes supported by the waveguide. In this case, an on-chip mode-exciting element is used to repeatably excite distinct collections of waveguide modes...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28238042/entotheonella-bacteria-as-source-of-sponge-derived-natural-products-opportunities-for-biotechnological-production
#14
Agneya Bhushan, Eike E Peters, Jörn Piel
Marine sponges belong to the oldest animals existing today. Apart from their role in recycling of carbon and nitrogen in the ocean, they are also an important source of a wide variety of structurally diverse bioactive natural products. Over the past few decades, a multitude of compounds from sponges have been discovered exhibiting diverse, pharmacologically promising activities. However, in many cases the low substance quantities present in the sponge tissue would require the collection of large amounts of sponge material, thus impeding further drug development...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28215332/fluorescence-exclusion-measurement-of-volume-in-live-cells
#15
C Cadart, E Zlotek-Zlotkiewicz, L Venkova, O Thouvenin, V Racine, M Le Berre, S Monnier, M Piel
Volume is a basic physical property of cells; however, it has been poorly investigated in cell biology so far, mostly because it is difficult to measure it precisely. Recently, large efforts were made to experimentally measure mammalian cell size and used mass, density, or volume as proxies for cell size. Here, we describe a method enabling cell volume measurements for single living cells. The method is based on the principle of fluorescent dye exclusion and can be easily implemented in cell biology laboratories...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28198609/an-unusual-flavin-dependent-halogenase-from-the-metagenome-of-the-marine-sponge-theonella-swinhoei-wa
#16
Duncan R M Smith, Agustinus R Uria, Eric J N Helfrich, Daniela Milbredt, Karl-Heinz van Pée, Jörn Piel, Rebecca J M Goss
Uncultured bacteria from sponges have been demonstrated to be responsible for the generation of many potent, bioactive natural products including halogenated metabolites.1 The identification of gene clusters from the metagenomes of such bacterial communities enables the discovery of enzymes that mediate new and useful chemistries and allows insight to be gained into the biogenesis of potentially pharmacologically important natural products. Here we report a new pathway to the keramamides (krm); the first functional evidence for the existence of a distinct producer in the Theonella swinhoei WA chemotype is revealed, and a key enzyme on the pathway, a unique flavin-dependent halogenase with a broad substrate specificity, with potential as a useful new biocatalytic tool, is described...
March 24, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28174679/engineering-remotely-triggered-liposomes-to-target-triple-negative-breast-cancer
#17
Alexandra Sneider, Rahul Jadia, Brandon Piel, Derek VanDyke, Christopher Tsiros, Prakash Rai
Triple Negative Breast Cancer (TNBC) continues to present a challenge in the clinic, as there is still no approved targeted therapy. TNBC is the worst sub-type of breast cancer in terms of prognosis and exhibits a deficiency in estrogen, progesterone, and human epidermal growth factor 2 (HER2) receptors. One possible option for the treatment of TNBC is chemotherapy. The issue with many chemotherapy drugs is that their effectiveness is diminished due to poor water solubility, and the method of administration directly or with a co-solvent intravenously can lead to an increase in toxicity...
2017: Oncomedicine
https://www.readbyqxmd.com/read/28159350/clinical-and-ethical-challenges-managing-acute-psychosis-in-pregnancy
#18
Carmen Croicu, Jennifer Piel, Suzanne B Murray
No abstract text is available yet for this article.
December 7, 2016: Psychosomatics
https://www.readbyqxmd.com/read/28117406/insights-into-the-planktothrix-genus-genomic-and-metabolic-comparison-of-benthic-and-planktic-strains
#19
Claire Pancrace, Marie-Anne Barny, Reiko Ueoka, Alexandra Calteau, Thibault Scalvenzi, Jacques Pédron, Valérie Barbe, Joern Piel, Jean-François Humbert, Muriel Gugger
Planktothrix is a dominant cyanobacterial genus forming toxic blooms in temperate freshwater ecosystems. We sequenced the genome of planktic and non planktic Planktothrix strains to better represent this genus diversity and life style at the genomic level. Benthic and biphasic strains are rooting the Planktothrix phylogenetic tree and widely expand the pangenome of this genus. We further investigated in silico the genetic potential dedicated to gas vesicles production, nitrogen fixation as well as natural product synthesis and conducted complementary experimental tests by cell culture, microscopy and mass spectrometry...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065305/micromanipulation-of-daughter-cells-for-the-study-of-cytokinetic-abscission
#20
J Lafaurie-Janvore, C Lafaurie, M Piel
The last step of cytokinesis, abscission, consists in the severing of the intercellular bridge connecting the two daughter cells. Because daughter cells move randomly on regular cell culture substrates, the use of adhesive micropatterns facilitates the observation of the intercellular bridge and its severing. Here we propose general rules to design micropatterns optimized to study this process. In particular, these micropatterns allow a good stabilization of the daughter cells and a predictable positioning of the intercellular bridge...
2017: Methods in Cell Biology
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