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https://www.readbyqxmd.com/read/28882762/estimation-of-the-diagnostic-performance-of-two-elisas-to-detect-pcv2-antibodies-in-pig-sera-using-a-bayesian-method
#1
C Fablet, N Rose, C Bernard, I Messager, Y Piel, B Grasland
This study was designed to assess the diagnostic characteristics of two PCV2 ELISAs without a gold standard. Four hundred and sixty-five serum samples from finishing pigs (25 herds) not vaccinated against PCV2 were used. Samples were tested by two ELISAs: an in-house ELISA (I-ELISA) and the commercial SERELISA(®)PCV2 Ab Mono Blocking kit (S-ELISA). A ROC curve was used to assess the S-ELISA's optimal threshold by taking the I-ELISA as a reference and using the cut-off previously determined by comparison to an cccmonolayer assay (IPMA)...
September 5, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28841998/quantitation-and-biospecific-identification-of-virus-like-particles-of-human-papillomavirus-by-capillary-electrophoresis
#2
Virginie Bettonville, Jérôme T J Nicol, Tania Furst, Nicolas Thelen, Géraldine Piel, Marc Thiry, Marianne Fillet, Nathalie Jacobs, Anne-Catherine Servais
Capillary electrophoresis (CE) for HPV-VLP quantitation is a very interesting alternative technique compared to those currently used in viral analysis, such as SDS-PAGE, Western blot or protein assay that are destructive and semi-quantitative or non specific. In this study, the quantitative performance of the CE method was evaluated. A main issue in virus quantitation is the absence of reference material. Therefore, the concentration of a HPV16-VLP sample produced in the laboratory was determined using ELISA with Gardasil(®), after adjuvant dissolution, as reference material and conformational H16...
December 1, 2017: Talanta
https://www.readbyqxmd.com/read/28840383/comprehensive-echocardiographic-assessment-of-biventricular-function-in-the-rabbit-animal-model-in-cardiovascular-research-feasibility-and-normal-values
#3
Sara Roldan Ramos, Guido Pieles, Wei Hui, Ryo Ishii, Cameron Slorach, Mark K Friedberg
Quantification of cardiac structure and function is central in cardiovascular research. Rabbits are valuable research models of cardiovascular human disease; however, there is little normal data available. The aim of this study was to investigate feasibility and provide normal values for comprehensive echocardiographic assessment of biventricular function in rabbits. New Zealand white rabbits underwent trans-thoracic echocardiography using a general electric (GE) Vivid 7/E9 system with a 10 MHz transducer, under light sedation, to evaluate biventricular function and dimensions...
August 24, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28837904/residential-proximity-to-agricultural-land-and-risk-of-brain-tumor-in-the-general-population
#4
Camille Carles, Ghislaine Bouvier, Yolande Esquirol, Clément Piel, Lucile Migault, Camille Pouchieu, Pascale Fabbro-Peray, Pierre Lebailly, Isabelle Baldi
The effect of pesticides on human health is still controversial, particularly as regards long-term health effects like cancer. The literature does suggest, however, that they could be involved in the occurrence of brain tumors, although the results concerning residential exposure are scarce. Our objective was to investigate the association between residential proximity to agricultural pesticides and brain tumors among adults in France by using a geographical information system. CERENAT is a population-based case-control study carried out in France in 2004-2006...
August 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28763511/correction-the-malagarasi-river-does-not-form-an-absolute-barrier-to-chimpanzee-movement-in-western-tanzania
#5
Alex K Piel, Fiona A Stewart, Lilian Pintea, Yingying Li, Miguel A Ramirez, Dorothy E Loy, Patricia A Crystal, Gerald H Learn, Leslie A Knapp, Paul M Sharp, Beatrice H Hahn
[This corrects the article DOI: 10.1371/journal.pone.0058965.].
2017: PloS One
https://www.readbyqxmd.com/read/28763317/rocuronium-is-more-hepatotoxic-than-succinylcholine-in-vitro
#6
Martin Sauer, Ines Piel, Cristof Haubner, Georg Richter, Miriam Mann, Gabriele Nöldge-Schomburg, Thomas Mencke
BACKGROUND: The development of liver failure is a major problem in critically ill patients. The hepatotoxicity of many drugs, as one important reason for liver failure, is poorly screened for in human models. Rocuronium and succinylcholine are neuromuscular blocking agents used for tracheal intubation and for rapid-sequence induction. OBJECTIVE: We used an in-vitro test with a permanent cell line and compared rocuronium and succinylcholine for hepatotoxicity. DESIGN: In-vitro study...
September 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28734287/on-the-thermophysical-and-transport-properties-of-3-he-and-4-he-a-bubble-interaction-potential-versus-state-of-the-art
#7
Michael Chrysos, Henri Piel
Three keynote thermophysical and transport properties of (3)He and (4)He, namely, the second virial coefficient, the shear viscosity, and the thermal conductivity, are reported for the "extended Dirac bubble potential" (EDbp), a novel model for He-He [M. Chrysos, J. Chem. Phys. 146, 024106 (2017)]. Comparisons with the experiment as well as with potentials with a proven track record and with the oversimplified Dbp are being made in the range 0.1-500 K to analyze the performance of the EDbp, which is shown here to emerge as a promising analytic model for He-He...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28723338/sickle-cell-disease
#8
LETTER
Frédéric B Piel, Martin H Steinberg, David C Rees
New England Journal of Medicine, Volume 377, Issue 3, Page 302-305, July 2017.
July 20, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28710536/resistance-to-tomato-leaf-curl-new-delhi-virus-in-melon-is-controlled-by-a-major-qtl-located-in-chromosome-11
#9
Cristina Sáez, Cristina Esteras, Cecilia Martínez, María Ferriol, Narinder P S Dhillon, Carmelo López, Belén Picó
Identification of three genomic regions and underlying candidate genes controlling the high level of resistance to ToLCNDV derived from a wild melon. SNP markers appropriated for MAS management of resistance. Tomato leaf curl New Delhi virus (ToLCNDV) is a bipartite begomovirus that severely affects melon crop (Cucumis melo) in the main production areas of Spain since 2012. In this work, we evaluated the degree of resistance of four accessions (two belonging to the subsp. agrestis var. momordica and two to the wild agrestis group) and their corresponding hybrids with a susceptible commercial melon belonging to the subsp...
July 14, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28685816/central-nervous-system-tumors-and-agricultural-exposures-in-the-prospective-cohort-agrican
#10
Clément Piel, Camille Pouchieu, Séverine Tual, Lucile Migault, Clémentine Lemarchand, Camille Carles, Mathilde Boulanger, Anne Gruber, Virginie Rondeau, Elisabeth Marcotullio, Pierre Lebailly, Isabelle Baldi
Studies in farmers suggest a possible role of pesticides in the occurrence of Central Nervous System (CNS) tumors but scientific evidence is still insufficient. Using data from the French prospective agricultural cohort AGRICAN (Agriculture & Cancer), we investigated the associations between exposure of farmers and pesticide users to various kinds of crops and animal farming and the incidence of CNS tumors, overall and by subtypes. Over the 2005-2007, 181,842 participants completed the enrollment questionnaire that collected a complete job calendar with lifetime history of farming types...
July 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28641118/mechanisms-for-fast-cell-migration-in-complex-environments
#11
REVIEW
Pablo Vargas, Lucie Barbier, Pablo José Sáez, Matthieu Piel
Cell migration depends on a combination of the cell's intrinsic capacity to move and the proper interpretation of external cues. This multistep process enables leukocytes to travel long distances in organs in just a few hours. This fast migration is partly due to the leukocytes' high level of plasticity, which helps them to adapt to a changing environment. Here, we review recent progress in understanding the mechanisms used by leukocytes to move rapidly and efficiently in intricate anatomical landscapes. We shall focus on specific cytoskeletal rearrangements used by neutrophils and dendritic cells to migrate within confined environments...
June 19, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28637194/high-iron-supply-inhibits-the-synthesis-of-the-genotoxin-colibactin-by-pathogenic-escherichia-coli-through-a-non-canonical-fur-ryhb-mediated-pathway
#12
Sophie Tronnet, Christophe Garcie, Alexander O Brachmann, Jörn Piel, Eric Oswald, Patricia Martin
The genotoxin colibactin is a secondary metabolite produced by a variety of pathogenic Enterobacteria, and is associated with colon cancer development and acute systemic infections. The colibactin biosynthesis requires the enzymatic activity of the phosphopantetheinyl transferase ClbA. We recently evidenced that two master regulators of bacterial iron homeostasis, i.e. the ferric uptake regulator (Fur) and the small regulatory non-coding RNA RyhB, were involved in the regulation of the clbA transcription and of the colibactin production...
July 31, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28621823/raw-material-procurement-for-termite-fishing-tools-by-wild-chimpanzees-in-the-issa-valley-western-tanzania
#13
Katarina Almeida-Warren, Volker Sommer, Alex K Piel, Alejandra Pascual-Garrido
OBJECTIVES: Chimpanzee termite fishing has been studied for decades, yet the selective processes preceding the manufacture of fishing tools remain largely unexplored. We investigate raw material selection and potential evidence of forward planning in the chimpanzees of Issa valley, western Tanzania. MATERIALS AND METHODS: Using traditional archaeological methods, we surveyed the location of plants from where chimpanzees sourced raw material to manufacture termite fishing tools, relative to targeted mounds...
June 16, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28584902/quantitative-trait-loci-analysis-of-melon-cucumis-melo-l-domestication-related-traits
#14
Aurora Díaz, Ana Montserrat Martín-Hernández, Ramón Dolcet-Sanjuan, Ana Garcés-Claver, José María Álvarez, Jordi Garcia-Mas, Belén Picó, Antonio José Monforte
Loci on LGIV, VI, and VIII of melon genome are involved in the control of fruit domestication-related traits and they are candidate to have played a role in the domestication of the crop. The fruit of wild melons is very small (20-50 g) without edible pulp, contrasting with the large size and high pulp content of cultivated melon fruits. An analysis of quantitative trait loci (QTL) controlling fruit morphology domestication-related traits was carried out using an in vitro maintained F2 population from the cross between the Indian wild melon "Trigonus" and the western elite cultivar 'Piel de Sapo'...
June 5, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28581484/autocatalytic-backbone-n-methylation-in-a-family-of-ribosomal-peptide-natural-products
#15
Niels S van der Velden, Noemi Kälin, Maximilian J Helf, Jörn Piel, Michael F Freeman, Markus Künzler
Peptide backbone N-methylation, as seen in cyclosporin A, has been considered to be exclusive to nonribosomal peptides. We have identified the first post-translationally modified peptide or protein harboring internal α-N-methylations through discovery of the genetic locus for the omphalotins, cyclic N-methylated peptides produced by the fungus Omphalotus olearius. We show that iterative autocatalytic activity of an N-methyltransferase fused to its peptide substrate is the signature of a new family of ribosomally encoded metabolites...
August 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28549176/effect-of-temperature-on-the-survival-and-development-of-three-forensically-relevant-dermestes-species-coleoptera-dermestidae
#16
Daniel Martín-Vega, Luisa M Díaz-Aranda, Arturo Baz, Blanca Cifrián
La mayoría de las especies del género Dermestes (Coleoptera: Dermestidae) son carroñeras durante la fase larvaria y la fase adulta, con preferencia por la materia orgánica seca. Debido a esto, los derméstidos son indicadores potencialmente útiles en las investigaciones forenses que impliquen restos humanos momificados y/o esqueléticos. Lamentablemente, los datos de referencia sobre el desarrollo de la mayoría de las especies de Dermestes de relevancia forense son escasos. Este estudio analiza el efecto de cinco temperaturas constantes (15, 20, 25, 30 y 35 °C) sobre la supervivencia y la tasa de desarrollo de tres de los derméstidos de mayor relevancia forense: Dermestes frischii Kugelan, Dermestes maculatus De Geer y Dermestes undulatus Brahm...
September 1, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28526733/discovery-and-optimization-of-hkt288-a-cadherin-6-targeting-adc-for-the-treatment-of-ovarian-and-renal-cancers
#17
Carl U Bialucha, Scott D Collins, Xiao Li, Parmita Saxena, Xiamei Zhang, Clemens Dürr, Bruno Lafont, Pierric Prieur, Yeonju Shim, Rebecca Mosher, David Lee, Lance Ostrom, Tiancen Hu, Sanela Bilic, Ivana Liric Rajlic, Vladimir Capka, Wei Jiang, Joel P Wagner, GiNell Elliott, Artur Veloso, Jessica C Piel, Meghan M Flaherty, Keith G Mansfield, Emily K Meseck, Tina Rubic-Schneider, Anne Serdakowski London, William R Tschantz, Markus Kurz, Duc Nguyen, Aaron Bourret, Matthew J Meyer, Jason E Faris, Mary J Janatpour, Vivien W Chan, Nicholas C Yoder, Kalli C Catcott, Molly A McShea, Xiuxia Sun, Hui Gao, Juliet Williams, Francesco Hofmann, Jeffrey A Engelman, Seth A Ettenberg, William R Sellers, Emma Lees
Despite an improving therapeutic landscape, significant challenges remain in treating the majority of patients with advanced ovarian or renal cancer. We identified the cell-cell adhesion molecule cadherin-6 (CDH6) as a lineage gene having significant differential expression in ovarian and kidney cancers. HKT288 is an optimized CDH6-targeting DM4-based antibody-drug conjugate (ADC) developed for the treatment of these diseases. Our study provides mechanistic evidence supporting the importance of linker choice for optimal antitumor activity and highlights CDH6 as an antigen for biotherapeutic development...
May 19, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28503405/nanoparticle-design-strategies-for-effective-cancer-immunotherapy
#18
Praveena Velpurisiva, Aniket Gad, Brandon Piel, Rahul Jadia, Prakash Rai
Cancer immunotherapy is a rapidly evolving and paradigm shifting treatment modality that adds a strong tool to the collective cancer treatment arsenal. It can be effective even for late stage diagnoses and has already received clinical approval. Tumors are known to not only avoid immune surveillance but also exploit the immune system to continue local tumor growth and metastasis. Because of this, most immunotherapies, particularly those directed against solid cancers, have thus far only benefited a small minority of patients...
2017: Journal of biomedicine
https://www.readbyqxmd.com/read/28500562/epithelial-growth-factor-receptor-expression-influences-5-ala-induced-glioblastoma-fluorescence
#19
Andrea O Fontana, Deborah Piffaretti, Francesco Marchi, Floriana Burgio, Ana Bela Faia-Torres, Paolo Paganetti, Sandra Pinton, Uwe Pieles, Michael Reinert
The extent of 5-aminolevulinic acid (5-ALA) guided tumor resection has a determining impact in high-grade glioma and glioblastoma surgery. Yet the intensity of the 5-ALA induced fluorescence may vary within the tumor. We aimed to correlate 5-ALA induced fluorescence with the expression of epithelial growth factor receptor (EGFR) and its constitutively active version EGFRvIII in different glioblastoma (GBM) cell lines. To elucidate the role of EGFR in the metabolism of 5-ALA in GBM cell lines with variable EGFR expression status, we analyzed the activation of EGFR by its primary ligand EGF, and its downstream effect on Heme oxygenase-1 (HO-1), a key enzyme regulating the metabolism of Protoporphyrin IX (PpIX), the fluorescent metabolite of 5-ALA...
July 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28493311/ethqv6-3-is-involved-in-melon-climacteric-fruit-ripening-and-is-encoded-by-a-nac-domain-transcription-factor
#20
Pablo Ríos, Jason Argyris, Juan Vegas, Carmen Leida, Merav Kenigswald, Galil Tzuri, Christelle Troadec, Abdelhafid Bendahmane, Nurit Katzir, Belén Picó, Antonio J Monforte, Jordi Garcia-Mas
Fruit ripening is divided into climacteric and non-climacteric types depending on the presence or absence of a transient rise in respiration rate and the production of autocatalytic ethylene. Melon is ideal for the study of fruit ripening, as both climacteric and non-climacteric varieties exist. Two introgressions of the non-climacteric accession PI 161375, encompassed in the QTLs ETHQB3.5 and ETHQV6.3, into the non-climacteric 'Piel de Sapo' background are able to induce climacteric ripening independently...
August 2017: Plant Journal: for Cell and Molecular Biology
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