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https://www.readbyqxmd.com/read/28472926/european-chlamydia-abortus-livestock-isolate-genomes-reveal-unusual-stability-and-limited-diversity-reflected-in-geographical-signatures
#1
H M B Seth-Smith, Leonor Sánchez Busó, M Livingstone, M Sait, S R Harris, K D Aitchison, Evangelia Vretou, V I Siarkou, K Laroucau, K Sachse, D Longbottom, N R Thomson
BACKGROUND: Chlamydia abortus (formerly Chlamydophila abortus) is an economically important livestock pathogen, causing ovine enzootic abortion (OEA), and can also cause zoonotic infections in humans affecting pregnancy outcome. Large-scale genomic studies on other chlamydial species are giving insights into the biology of these organisms but have not yet been performed on C. abortus. Our aim was to investigate a broad collection of European isolates of C. abortus, using next generation sequencing methods, looking at diversity, geographic distribution and genome dynamics...
May 4, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28431520/infectious-agents-is-a-risk-factor-for-myxomatous-mitral-valve-degeneration-a-case-control-study
#2
Marcos Gradim Tiveron, Pablo Maria Alberto Pomerantzeff, Maria de Lourdes Higuchi, Marcia Martins Reis, Jaqueline de Jesus Pereira, Joyce Tieko Kawakami, Renata Nishiyama Ikegami, Carlos Manuel de Almeida Brandao, Fabio Biscegli Jatene
BACKGROUND: The etiology of myxomatous mitral valve degeneration (MVD) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. The purpose of the study is to analyze the effect of Mycoplasma pneumoniae (Mp), Chlamydophila pneumoniae (Cp) and Borrelia burgdorferi (Bb) on myxomatous mitral valve degeneration pathogenesis and establish whether increased in inflammation and collagen degradation in myxomatous mitral valve degeneration etiopathogenesis...
April 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28393985/-importance-of-respiratory-virus-in-immunocompetent-adult-patients-hospitalized-with-community-acquired-pneumonia
#3
Fernando Saldías Peñafiel, Marcos Ortega Gutiérrez, Gino Fuentes López, José Manuel Elola Aránguiz, Javier Uribe Monasterio, Arturo Morales Soto, Orlando Díaz Patiño
BACKGROUND: Community-acquired pneumonia (CAP) is a relevant worldwide cause of morbidity and mortality in adult population, however its etiology is often not identified and therapy is empirical. AIM: To assess the etiology of CAP in immunocompetent adult hospitalized patients using conventional and molecular diagnostic methods. MATERIAL AND METHODS: We prospectively studied 240 adult patients who were hospitalized for CAP to identify the microbial etiology...
December 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28376442/prevalence-of-atypical-pathogens-in-patients-with-cough-and-community-acquired-pneumonia-a-meta-analysis
#4
REVIEW
Christian Marchello, Ariella Perry Dale, Thuy Nhu Thai, Duk Soo Han, Mark H Ebell
PURPOSE: Community-acquired pneumonia (CAP), acute cough, bronchitis, and lower respiratory tract infections (LRTI) are often caused by infections with viruses or Streptococcus pneumoniae. The prevalence of atypical pathogens Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis among patients with these illnesses in the ambulatory setting has not been previously summarized. We set out to derive prevalence information from the existing literature...
November 2016: Annals of Family Medicine
https://www.readbyqxmd.com/read/28256360/the-relationship-of-chlamydophila-pneumoniae-with-schizophrenia-the-role-of-brain-derived-neurotrophic-factor-bdnf-and-neurotrophin-3-nt-3-in-this-relationship
#5
Fatma Kalayci, Armagan Ozdemir, Suat Saribas, Pelin Yuksel, Sevgi Ergin, Ali Mert Kuskucu, Cana Aksoy Poyraz, Ibrahim Balcioglu, Nihat Alpay, Aykut Kurt, Zeynep Sezgin, Banu Tufan Kocak, Rana Sucu Icel, Gunay Can, Hrisi Bahar Tokman, Bekir Kocazeybek
Several pathogens have been suspected of playing a role in the pathogenesis of schizophrenia. Chronic inflammation has been proposed to occur as a result of persistent infection caused by Chlamydophila pneumoniae cells that reside in brain endothelial cells for many years. It was recently hypothesized that brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) may play prominent roles in the development of schizophrenia. NT-3 and BDNF levels have been suggested to change in response to various manifestations of infection...
February 28, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28159161/atypical-pneumonia-updates-on-legionella-chlamydophila-and-mycoplasma-pneumonia
#6
REVIEW
Lokesh Sharma, Ashley Losier, Thomas Tolbert, Charles S Dela Cruz, Chad R Marion
Community-acquired pneumonia (CAP) has multiple causes and is associated with illness that requires admission to the hospital and mortality. The causes of atypical CAP include Legionella species, Chlamydophila, and Mycoplasma. Atypical CAP remains a diagnostic challenge and, therefore, likely is undertreated. This article reviews the advancements in the evaluation and treatment of patients and discusses current conflicts and controversies of atypical CAP.
March 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/28157451/the-role-of-nod-like-receptors-in-pulmonary-infection
#7
Kristin M Wiese, Bria M Coates, Karen M Ridge
Pneumonia is caused by both viral and bacterial pathogens and is responsible for a significant health burden in the Unites States. The innate immune system is the human body's first line of defense against these pathogens. The recognition of invading pathogens via pattern recognition receptors (PRRs) leads to proinflammatory cytokine and chemokine production followed by recruitment and activation of effector immune cells. The nonspecific inflammatory nature of the innate immune response can result in immunopathology that is detrimental to the host...
February 3, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28149490/occurrence-of-chlamydophila-felis-feline-herpesvirus-1-and-calcivirus-in-domestic-cats-of-iran
#8
Nadi Maazi, Shahram Jamshidi, Payman Kayhani, Hassan Momtaz
BACKGROUND AND OBJECTIVES: Feline herpesvirus-1, feline calicivirus and Chlamydophila felis are the main causes of feline upper respiratory tract disease. This study was conducted to identify of FeHV-1, FCV and C. felis infections in domestic cat population and also to estimate the prevalence of each specific infection in Iran. MATERIALS AND METHODS: The ocular conjunctiva and oropharyngeal specimens obtained from 80 cats were examined using PCR and reverse transcription PCR...
October 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28121925/prospective-etiological-investigation-of-community-acquired-pulmonary-infections-in-hospitalized-people-living-with-hiv
#9
Claudia Figueiredo-Mello, Pontus Naucler, Marinella D Negra, Anna S Levin
The study of the etiological agents of community-acquired pulmonary infections is important to guide empirical therapy, requires constant updating, and has a substantial impact on the prognosis of patients. The objective of this study is to determine prospectively the etiology of community-acquired pulmonary infections in hospitalized adults living with HIV. Patients were submitted to an extended microbiological investigation that included molecular methods. The microbiological findings were evaluated according to severity of the disease and pneumococcal vaccine status...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28099077/disease-complexity-in-a-declining-alaskan-muskox-ovibos-moschatus-population
#10
Josephine A Afema, Kimberlee B Beckmen, Stephen M Arthur, Kathy Burek Huntington, Jonna A K Mazet
The muskox ( Ovibos moschatus ) population inhabiting the eastern North Slope (ENS) of Alaska, US declined dramatically during 1999-2006, whereas populations in western Alaska (WA) were stable or increasing. To understand morbidity and mortality factors contributing to the decline, Alaska Department of Fish and Game conducted pathologic investigations of carcasses from 2005 until 2008. Additionally, archived sera from both ENS and WA muskoxen collected during 1984-92, before the documented beginning of the ENS decline; sera collected during 2000, near the beginning of the decline; and contemporary sera (from live capture-release, adult females) collected during 2006, 2007, and 2008 were analyzed to determine whether prevalence of antibody to potential pathogens differed in the two areas or changed over time...
April 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28062246/prevalence-of-chlamydophila-pneumoniae-and-mycoplasma-pneumoniae-igm-and-igg-antibodies-in-tunisian-patients-presenting-with-exacerbation-of-chronic-obstructive-pulmonary-disease
#11
S Messous, I Trabelsi, M H Grissa, S Nouira, B Pozzetto, M Mastouri
OBJECTIVE: We aimed to assess the prevalence of Chlamydophila pneumoniae and Mycoplasma pneumoniae acute infections, using serological testing, in patients admitted to the emergency department for acute exacerbations of chronic obstructive pulmonary disease (COPD). METHODS: We performed a prospective observational study of 100 consecutive patients. Serum specimens were collected at day 0 and day 15. C. pneumoniae and M. pneumoniae antibodies (IgM and IgG) were tested by commercial ELISA and immunofluorescence assay, respectively...
January 3, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28049398/infectious-agents-and-neurodegenerative-diseases-exploring-the-links
#12
Mohammad Zubair Alam, Qamre Alam, Mohammad Amjad Kamal, Asif Ahmad Jiman-Fatani, Esam I Azhar, Mohammad Azhar Khan, Absarul Haque
Recent studies have shown that bacterial and viral infections are risk factors for various neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), Multiple Sclerosis (MS), Alzheimer's disease (AD), and Lyme disease (LD). However, it is still controversial how the infections play a role in neurological diseases progression. Infections in central nervous system may lead multiple damages in infected and neighboring cells. The infection leads to the activation of inflammatory processes and host immune responses, which acts as defense mechanism and also causes damage to the host neuronal functions and viability...
January 3, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27960208/community-acquired-pneumonia-in-the-asia-pacific-region
#13
Jae-Hoon Song, Kyungmin Huh, Doo Ryeon Chung
Community-acquired pneumonia (CAP) is an important cause of mortality and morbidity worldwide. Aging population, dense urbanization, and poor access to health care make the Asia-Pacific region vulnerable to CAP. The high incidence of CAP poses a significant health and economic burden in this region. Common etiologic agents in other global regions including Streptococcus pneumoniae, Mycoplasma pneumoniae, Haemophilus influenzae, Chlamydophila pneumoniae, Staphylococcus aureus, and respiratory viruses are also the most prevalent pathogens in the Asia-Pacific region...
December 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27866051/insights-into-structure-and-function-of-30s-ribosomal-protein-s2-30s2-in-chlamydophila-pneumoniae-a-potent-target-of-pneumonia
#14
G Koteswara Reddy, K Nagamalleswara Rao, Kiran Yarrakula
The gene 30S ribosomal protein S2 (30S2) is identified as a potential drug and vaccine target for Pneumonia. Its structural characterization is an important to understand the mechanism of action for identifying its receptor and/or other binding partners. The comparative genomics and proteomics studies are useful for structural characterization of 30S2 in C. Pneumoniae using different bioinformatics tools and web servers. In this study, the protein 30S2 structure was modelled and validated by Ramachandran plot...
February 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/27800148/prevalence-and-seasonal-distribution-of-respiratory-viruses-during-the-2014-2015-season-in-istanbul
#15
Safak Goktas, Mumtaz Cem Sirin
BACKGROUND: Acute respiratory tract infection (ARTI) is one of the most common infections worldwide, causing significant morbidity and mortality. OBJECTIVES: This study was conducted to determine the prevalence and seasonal distribution of respiratory viruses in our region, in children and adults with a pre-diagnosis of ARTI. METHODS: A total of 845 nasopharyngeal swab specimens were analyzed with the RespiFinder Smart 22 kit (PathoFinder BV, Netherlands) and the Rotor-Gene 6000 real-time PCR system...
September 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27793655/infectious-burden-and-semen-parameters
#16
E Moretti, N Figura, M S Campagna, F Iacoponi, S Gonnelli, G Collodel
OBJECTIVE: To investigate the relationship between chronic infections detected in serum and semen quality. The pathogen burden is a concept consisting in the observation that, in patients with heart disease, damaging effects of the coronary arteries increase concomitantly with the number of agents responsible for chronic infections to which patients mounted a serological response. Previous observations that Helicobacter pylori infection may reduce the semen quality prompted us to perform the present study...
October 25, 2016: Urology
https://www.readbyqxmd.com/read/27776489/respiratory-microbes-present-in-the-nasopharynx-of-children-hospitalised-with-suspected-pulmonary-tuberculosis-in-cape-town-south-africa
#17
Felix S Dube, Mamadou Kaba, F J Lourens Robberts, Lemese Ah Tow, Sugnet Lubbe, Heather J Zar, Mark P Nicol
BACKGROUND: Lower respiratory tract infection in children is increasingly thought to be polymicrobial in origin. Children with symptoms suggestive of pulmonary tuberculosis (PTB) may have tuberculosis, other respiratory tract infections or co-infection with Mycobacterium tuberculosis and other pathogens. We aimed to identify the presence of potential respiratory pathogens in nasopharyngeal (NP) samples from children with suspected PTB. METHOD: NP samples collected from consecutive children presenting with suspected PTB at Red Cross Children's Hospital (Cape Town, South Africa) were tested by multiplex real-time RT-PCR...
October 24, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27771116/coxiella-burnetii-detected-in-three-species-of-endangered-north-african-gazelles-that-recently-aborted
#18
Elena García, Gerardo Espeso, Rocío Fernández, Ángel Gómez-Martín, José María Rodríguez-Linde, Christian De la Fe
Coxiella (C.) burnetii is the etiological agent of the zoonotic disease known a Q fever. This agent can infect multiple hosts although its pathogenic potential in wild ruminants has been poorly studied. The polymerase chain reaction and the serological test detected the presence of C. burnetii in a population of North African gazelles (n = 355), comprising dorcas gazelle (Gazella dorcas neglecta), dama gazelle (Nanger dama mhorr) and Cuvier's gazelle (Gazella cuvieri) which, some of them, they recently aborted...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27721281/application-of-serology-and-nested-polymerase-chain-reaction-for-identifying-chlamydophila-pneumoniae-in-community-acquired-lower-respiratory-tract-infections-in-children
#19
Surinder Kumar, Sanjeev R Saigal, Gulshan Rai Sethi, Sanchit Kumar
CONTEXT: Chlamydophila pneumoniae is a common cause of community-acquired respiratory infections, including pneumonia, bronchitis, and upper respiratory tract infections. Since it is difficult to detect C. pneumoniae in clinical practice, specific etiological diagnosis is established only in a minority of cases. AIMS: To investigate the role of C. pneumoniae in community-acquired lower respiratory tract infections (LRTIs) in children, with the use of serological tests and nested polymerase chain reaction (PCR) analysis...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27595750/culture-independent-genomic-characterisation-of-candidatus-chlamydia-sanzinia-a-novel-uncultivated-bacterium-infecting-snakes
#20
Alyce Taylor-Brown, Nathan L Bachmann, Nicole Borel, Adam Polkinghorne
BACKGROUND: Recent molecular studies have revealed considerably more diversity in the phylum Chlamydiae than was previously thought. Evidence is growing that many of these novel chlamydiae may be important pathogens in humans and animals. A significant barrier to characterising these novel chlamydiae is the requirement for culturing. We recently identified a range of novel uncultured chlamydiae in captive snakes in Switzerland, however, nothing is known about their biology. Using a metagenomics approach, the aim of this study was to characterise the genome of a novel chlamydial taxon from the choana of a captive snake...
2016: BMC Genomics
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