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https://www.readbyqxmd.com/read/29164915/establishment-of-a-bordetella-avium-challenge-model-in-turkeys
#1
Rebecca Knab, Henning Petersen, Silke Rautenschlein, Arne Jung
Despite the importance of Bordetella avium (BA) as a respiratory pathogen of young turkeys, no infection model for the evaluation of BA-vaccine efficacy is available. The objective of this study was to evaluate the influence of route and dose of infection on the establishment of a BA-challenge model. In our first experiment, 28-day-old turkeys were either inoculated oculonasally with 10(5), 10(7) or 10(9) colony forming units (CFU) of BA per animal or exposed to BA by aerosol with 10(5)-10(8) CFU/m(3). The respiratory tract of all inoculated animals was BA-colonised, which was confirmed by choanal swabs and samples of trachea and lung, showing the highest prevalence in the aerosol inoculated group...
November 22, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29164393/bordetella-pertussis-virulence-factors-in-the-continuing-evolution-of-whooping-cough-vaccines-for-improved-performance
#2
REVIEW
Dorji Dorji, Frits Mooi, Osvaldo Yantorno, Rajendar Deora, Ross M Graham, Trilochan K Mukkur
Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced the mortality due to pertussis. Despite induction of both antibody and cell-mediated immune (CMI) responses by aP and wP vaccines, there has been resurgence of pertussis in many countries in recent years. Possible reasons hypothesised for resurgence have ranged from incompliance with the recommended vaccination programmes with the currently used aP vaccine to infection with a resurged clinical isolates characterised by mutations in the virulence factors, resulting in antigenic divergence with vaccine strain, and increased production of pertussis toxin, resulting in dampening of immune responses...
November 21, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29158617/pertussis-outbreak-in-polish-shooters-with-adverse-event-analysis
#3
Monika Skrzypiec-Spring, Jarosław Krzywański, Monika Karlikowska-Skwarnik, Andrzej Pokrywka, Hubert Krysztofiak, Aneta Nitsch-Osuch, Ernest Kuchar
In addition to different injuries, infections are the most common reason for giving up training altogether or reducing its volume and intensity, as well as a lack of opportunities to participate in sports competitions. Nowadays, a slow but constant re-emergence of pertussis, especially among teenagers and young adults, including athletes, can be observed. This paper describes an outbreak of pertussis among professional Polish shooters, focusing on the transmission of Bordetella pertussis infection between members of the national team, its influence on performance capacity and adverse event analysis...
September 2017: Biology of Sport
https://www.readbyqxmd.com/read/29135925/membrane-active-properties-of-an-amphitropic-peptide-from-the-cyaa-toxin-translocation-region
#4
Alexis Voegele, Orso Subrini, Nicolas Sapay, Daniel Ladant, Alexandre Chenal
The adenylate cyclase toxin CyaA is involved in the early stages of infection by Bordetella pertussis, the causative agent of whooping cough. CyaA intoxicates target cells by a direct translocation of its catalytic domain (AC) across the plasma membrane and produces supraphysiological levels of cAMP, leading to cell death. The molecular process of AC translocation remains largely unknown, however. We have previously shown that deletion of residues 375-485 of CyaA selectively abrogates AC translocation into eukaryotic cells...
November 14, 2017: Toxins
https://www.readbyqxmd.com/read/29109248/dgr-mutagenic-transposition-occurs-via-hypermutagenic-reverse-transcription-primed-by-nicked-template-rna
#5
Santa S Naorem, Jin Han, Shufang Wang, William R Lee, Xiao Heng, Jeff F Miller, Huatao Guo
Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a template repeat (TR) to a variable repeat (VR) that results in adenine-to-random nucleotide conversions. Here we show that reverse transcription of the Bordetella phage DGR is primed by an adenine residue in TR RNA and is dependent on the DGR-encoded reverse transcriptase (bRT) and accessory variability determinant (Avd ), but is VR-independent...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29099909/a-population-based-study-of-recurrent-symptomatic-bordetella-pertussis-infections-in-children-in-california-2010-2015
#6
Lauren Platt, Melissa Thun, Kathleen Harriman, Kathleen Winter
Background: Natural infection with Bordetella pertussis is thought to result in 4-20 years of immunity against subsequent symptomatic pertussis infection. However, these estimates are based on studies in unvaccinated or whole-cell pertussis-vaccinated children. We conducted a population-based study of pertussis infection and reinfection during a 5-year period in California in an cohort vaccinated exclusively with acellular pertussis (aP) vaccine. Methods: California surveillance data were reviewed to identify all children with 2 reported incidents of pertussis with symptom onset between 1 January 2010 and 31 December 2015...
November 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29076101/bordetella-pertussis-infection-in-hospitalized-infants-with-acute-bronchiolitis
#7
Şule Gökçe, Zafer Kurugöl, S Şöhret Aydemir, Candan Çiçek, Aslı Aslan, Güldane Koturoğlu
OBJECTIVE: To assess the frequency of B. pertussis infection among young infants hospitalized with acute bronchiolitis and to determine whether B. pertussis infection affects the clinical course of acute bronchiolitis. METHODS: A total of 172 infants <6 months of age hospitalized with acute bronchiolitis were tested for B. pertussis and respiratory viruses with real-time PCR. Cases were divided into 2 groups according to B. pertussis positive or negative. Clinical parameters, clinical severity scores and laboratory characteristics of the pertussis-positive and pertussis-negative cases were compared...
October 27, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29052540/emergence-of-bordetella-holmesii-as-a-causative-agent-of-whooping-cough-barcelona-spain
#8
Alba Mir-Cros, Gema Codina, M Teresa Martín-Gómez, Anna Fàbrega, Xavier Martínez, Mireia Jané, Diego Van Esso, Thais Cornejo, Carlos Rodrigo, Magda Campins, Tomàs Pumarola, Juan José González-López
We describe the detection of Bordetella holmesii as a cause of whooping cough in Spain. Prevalence was 3.9% in 2015, doubling to 8.8% in 2016. This emergence raises concern regarding the contribution of B. holmesii to the reemergence of whooping cough and the effectiveness of the pertussis vaccine.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29052125/differences-in-innate-ifn%C3%AE-and-il-17-responses-to-bordetella-pertussis-between-balb-c-and-c57bl-6-mice-role-of-%C3%AE-%C3%AE-t-cells-nk-cells-and-dendritic-cells
#9
Yung-Yi C Mosley, Fangjia Lu, Harm HogenEsch
Cell-mediated immune responses characterized by the secretion of IFNγ and IL-17 play an important role in the immune response to Bordetella pertussis (B. pertussis). We investigated innate sources of IFNγ and IL-17 upon stimulation of spleen cells from BALB/c (B/c) and C57BL/6 (B6) mice with heat-killed B. pertussis (hkBp). Spleen cells from B/c mice secreted less IFNγ and more IL-17 than those from B6 mice. Innate IFNγ was produced predominantly by NK cells in B/c mice and by CD8 T cells and NK cells in B6 mice...
October 19, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29045690/clinical-characteristics-of-hospitalized-infants-with-laboratory-confirmed-pertussis-in-guatemala
#10
Varun K Phadke, John P McCracken, Jennifer L Kriss, Maria R Lopez, Kim A Lindblade, Joe P Bryan, Miguel E Garcia, Carlos E Funes, Saad B Omer
Background: Pertussis is an important cause of hospitalization and death in infants too young to be vaccinated (aged <2 months). Limited data on infant pertussis have been reported from Central America. The aim of this study was to characterize acute respiratory illnesses (ARIs) attributable to Bordetella pertussis among infants enrolled in an ongoing surveillance study in Guatemala. Methods: As part of a population-based surveillance study in Guatemala, infants aged <2 months who presented with ARI and required hospitalization were enrolled, and nasopharyngeal and oropharyngeal swab specimens were obtained...
October 13, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29037454/incidence-of-pertussis-in-subjects-aged-50years-and-older-in-france-in-2013-2014
#11
N Guiso, J-L Gallais, G Gavazzi, D Pinquier, J Gaillat
OBJECTIVE: To assess the incidence of pertussis (whooping cough) in subjects aged 50years and older in France. METHODS: Participating family physicians (FPs) using the patient record management software AxiSanté(®) included patients aged 50years and older, who had signed an informed consent form, presenting with persistent cough for 7 to 21days. Bordetella genetic material was detected by polymerase chain reaction (PCR) on nasopharyngeal samples collected at the FP's discretion...
October 13, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29034215/the-proteome-of-biologically-active-membrane-vesicles-from-piscirickettsia-salmonis-lf-89-type-strain-identifies-plasmid-encoded-putative-toxins
#12
Cristian Oliver, Mauricio A Hernández, Julia I Tandberg, Karla N Valenzuela, Leidy X Lagos, Ronie E Haro, Patricio Sánchez, Pamela A Ruiz, Constanza Sanhueza-Oyarzún, Marcos A Cortés, María T Villar, Antonio Artigues, Hanne C Winther-Larsen, Ruben Avendaño-Herrera, Alejandro J Yáñez
Piscirickettsia salmonis is the predominant bacterial pathogen affecting the Chilean salmonid industry. This bacterium is the etiological agent of piscirickettsiosis, a significant fish disease. Membrane vesicles (MVs) released by P. salmonis deliver several virulence factors to host cells. To improve on existing knowledge for the pathogenicity-associated functions of P. salmonis MVs, we studied the proteome of purified MVs from the P. salmonis LF-89 type strain using multidimensional protein identification technology...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29026471/pertussis-and-pertussis-like-illness-pediatric-experience-in-oman
#13
Amal Al Maani, Abdullah Al Qayoudhi, Hanan Fawzi Nazir, Heba Omar, Amina Al Jardani, Zakariya Al Muharrmi, Yasser Wali
OBJECTIVES: A resurgence of pertussis or whooping cough has been observed worldwide despite broad vaccination coverage. Pertussis like illness (PLI) refers to a clinical syndrome compatible with pertussis infection but lacking laboratory confirmation or an epidemiological link to a confirmed case. Our study aimed to estimate the contribution of Bordetella pertussis infection and identifying predictors of its diagnosis in a cohort of children with PLI. METHODS: Demographic and clinical information were retrospectively collected from the medical records of children < 13 years old and hospitalized for PLI in two pediatric units in Oman from 1 January 2012 to 31 December 2013...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29025851/investigating-bordetella-pertussis-colonisation-and-immunity-protocol-for-an-inpatient-controlled-human-infection-model
#14
Hans de Graaf, Diane Gbesemete, Andrew R Gorringe, Dimitri A Diavatopoulos, Kent E Kester, Saul N Faust, Robert C Read
INTRODUCTION: We summarise an ethically approved protocol for the development of an experimental human challenge colonisation model. Globally Bordetella pertussis is one of the leading causes of vaccine-preventable death. Many countries have replaced whole cell vaccines with acellular vaccines over the last 20 years during which pertussis appears to be resurgent in a number of countries in the developed world that boast high immunisation coverage. The acellular vaccine provides relatively short-lived immunity and, in contrast to whole cell vaccines, may be less effective against colonisation and subsequent transmission...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29018122/the-bvgas-regulon-of-bordetella-pertussis
#15
Kyung Moon, Richard P Bonocora, David D Kim, Qing Chen, Joseph T Wade, Scott Stibitz, Deborah M Hinton
Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA. When BvgS is active, BvgA is phosphorylated (BvgA~P), and virulence-activated genes (vags) are expressed [Bvg(+) mode]. When BvgS is inactive and BvgA is not phosphorylated, virulence-repressed genes (vrgs) are induced [Bvg(-) mode]. Here, we have used transcriptome sequencing (RNA-seq) and reverse transcription-quantitative PCR (RT-qPCR) to define the BvgAS-dependent regulon of B...
October 10, 2017: MBio
https://www.readbyqxmd.com/read/28993360/pertussis-manifesting-as-recurrent-cough-and-wheezing-in-an-incompletely-vaccinated-8-month-old-infant
#16
Dimitri Poddighe, Marco Giuseppe Nedbal, Nunzia Mastricci, Paola Bruni
Pertussis is an acute respiratory illness caused by Bordetella pertussis, showing a re-emergence in developed countries. However, it is probably under-recognised and, as a consequence, its burden is underestimated. Here, we report the clinical case of an infant diagnosed with pertussis, despite a regular schedule of vaccination, thanks to a careful clinical evaluation, including personal and family history. In addition to pointing the attention on a precocious diagnosis of atypical cases of pertussis, this case report further raised the issue of modifying and/or implementing the immunisation strategy, considering the ongoing changes of social (eg, immigration) and sanitary (eg, vaccine coverage) background in Italy and all over the Europe...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28984566/pertussis-associated-persistent-cough-in-previously-vaccinated-children
#17
Nicola Principi, David Litt, Leonardo Terranova, Marina Picca, Concetta Malvaso, Cettina Vitale, Norman K Fry, Susanna Esposito, The Italian Pertussis Group For Persistent Cough In Children
To evaluate the role of Bordetella pertussis infection, 96 otherwise healthy 7- to 17-year-old subjects who were suffering from a cough lasting from 2 to 8 weeks were prospectively recruited. At enrolment, a nasopharyngeal swab and an oral fluid sample were obtained to search for pertussis infection by the detection of B. pertussis DNA and/or an elevated titre of anti-pertussis toxin IgG. Evidence of pertussis infection was found in 18 (18.7 %; 95 % confidence interval, 11.5-28.0) cases. In 15 cases, the disease occurred despite booster administration...
October 6, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28980823/physiopathological-roles-of-spontaneously-released-outer-membrane-vesicles-of-bordetella-pertussis
#18
Gianmarco Gasperini, Vanessa Arato, Mariagrazia Pizza, Beatrice Aricò, Rosanna Leuzzi
AIM: Bordetella pertussis has been shown to release outer membrane vesicles (OMV) both in vitro and in vivo but little is known about their biological role during the initial phases of B. pertussis infection of the airways. RESULTS: We have demonstrated that OMV are released by B. pertussis in a human ciliated-airway cell model and purified vesicles can interact with host cells. Binding and uptake are strictly Bvg-regulated and OMV-associated. Pertussis toxin contributes to host-cell intoxication...
October 5, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28974408/whooping-cough-surveillance-in-france-in-pediatric-private-practice-in-2006-2015
#19
Nicole Guiso, Corinne Levy, Olivier Romain, Sophie Guillot, Andreas Werner, Marie Charlotte Rondeau, Stéphane Béchet, Robert Cohen
BACKGROUND: Increasing incidence of whooping cough (pertussis) has been reported in many countries, attributed to a switch from whole-cell pertussis-containing vaccine (wPV) to acellular PV (aPV) and circulation of the pertactin non-producing Bordetella pertussis. The present study aimed to estimate the duration of immunity conferred by PVs in children in France with data from an ongoing pediatric ambulatory surveillance of pertussis. METHODS: A total of 64 pediatricians throughout France enrolled children with suspected pertussis...
October 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28973366/an-extracellular-polysaccharide-locus-required-for-transmission-of-bordetella-bronchiseptica
#20
Kalyan K Dewan, Dawn L Taylor-Mulneix, Lindsay J Hilburger, Israel Rivera, Andrew Preston, Eric T Harvill
Background: The lack of animal models to experimentally study how infectious agents transmit between hosts limits our understanding of what makes some pathogens so contagious. Methods: We recently developed a Bordetella bronchiseptica mouse model to study transmission and have used it to assess, for the first time, which of several well-studied "virulence factors" common to classical Bordetella species contribute to transmission. Results: Among 13 mutants screened, a mutant lacking an extracellular polysaccharide (EPS) locus consistently failed to transmit...
October 17, 2017: Journal of Infectious Diseases
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