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https://www.readbyqxmd.com/read/29346850/trends-in-the-minimum-inhibitory-concentrations-of-erythromycin-clarithromycin-azithromycin-ciprofloxacin-and-trimethoprim-sulfamethoxazole-for-strains-of-bordetella-pertussis-isolated-in-the-czech-republic-in-1967-2015
#1
Vladislav Jakubů, Jana Zavadilová, Kateřina Fabiánová, Urbášková Pavla
No abstract text is available yet for this article.
December 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29346585/maternal-vaccination-with-a-mono-component-pertussis-toxoid-vaccine-is-sufficient-to-protect-infants-in-a-baboon-model-of-whooping-cough
#2
Parul Kapil, James F Papin, Roman F Wolf, Lindsey I Zimmerman, Leslie D Wagner, Tod J Merkel
Background: Bordetella pertussis is a human pathogen responsible for serious respiratory illness. The disease is most severe in infants too young to be vaccinated with most hospitalizations and deaths occurring within this age group. The Advisory Committee on Immunization Practices recommended immunization of pregnant women to protect infants from birth until their first vaccination at six to eight weeks of age. We previously demonstrated that maternal vaccination with licensed acellular pertussis vaccines protected newborn baboons from disease...
January 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29342383/rib-fracture-associated-with-bordetella-pertussis-infection
#3
John A Zambrano, Talia N Herman
A 66-year-old woman presented to her primary care physician’s office with a 2-week history of dry cough and severe pain in the right flank. Five days before presentation, she had received a diagnosis of viral upper respiratory tract infection, but her symptoms had not abated with supportive..
January 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29337218/calcium-dependent-disorder-to-order-transitions-are-central-to-the-secretion-and-folding-of-the-cyaa-toxin-of-bordetella-pertussis-the-causative-agent-of-whooping-cough
#4
Darragh P O'Brien, Ana Cristina Sotomayor Perez, Johanna Karst, Sara E Cannella, Véronique Yvette Ntsogo Enguéné, Audrey Hessel, Dorothée Raoux-Barbot, Alexis Voegele, Orso Subrini, Marilyne Davi, J Inaki Guijarro, Bertrand Raynal, Bruno Baron, Patrick England, Belen Hernandez, Mahmoud Ghomi, Véronique Hourdel, Christian Malosse, Julia Chamot-Rooke, Patrice Vachette, Dominique Durand, Sébastien Brier, Daniel Ladant, Alexandre Chenal
The adenylate cyclase toxin (CyaA) plays an essential role in the early stages of respiratory tract colonization by Bordetella pertussis, the causative agent of whooping cough. Once secreted, CyaA invades eukaryotic cells, leading to cell death. The cell intoxication process involves a unique mechanism of translocation of the CyaA catalytic domain directly across the plasma membrane of the target cell. Herein, we review our recent results describing how calcium is involved in several steps of this intoxication process...
January 11, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29310361/severe-pertussis-infection-a-clinicopathological-study
#5
Fernando Palvo, Alexandre Todorovic Fabro, Maria Célia Cervi, Davi Casale Aragon, Fernando Silva Ramalho, Ana Paula de Carvalho Panzeri Carlotti
We aimed to investigate the clinicopathological features of pertussis in children admitted to a tertiary-care university hospital in Brazil.This was a retrospective cohort study of all pediatric hospital admissions with pertussis from January 1, 2008 to December 31, 2014. We also reported the autopsy findings in children who died.Fifty-five patients admitted to the hospital over the study period had laboratorial confirmation of Bordetella pertussis infection, 17 (30.9%) needed pediatric intensive care unit (PICU) admission and 6 (10...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29306640/species-interactions-may-help-explain-the-erratic-periodicity-of-whooping-cough-dynamics
#6
Samit Bhattacharyya, Matthew J Ferrari, Ottar N Bjørnstad
Incidence of whooping cough exhibits variable dynamics across time and space. The periodicity of this disease varies from annual to five years in different geographic regions in both developing and developed countries. Many hypotheses have been put forward to explain this variability such as nonlinearity and seasonality, stochasticity, variable recruitment of susceptible individuals via birth, immunization, and immune boosting. We propose an alternative hypothesis to describe the variability in periodicity - the intricate dynamical variability of whooping cough may arise from interactions between its dominant etiological agents of Bordetella pertussis and Bordetella parapertussis...
December 14, 2017: Epidemics
https://www.readbyqxmd.com/read/29302815/long-lasting-cough-in-an-adult-german-population-incidence-symptoms-and-related-pathogens
#7
Raphael Weinberger, Marion Riffelmann, Nicole Kennerknecht, Christel Hülße, Martina Littmann, Judith O'Brien, Rüdiger von Kries, Carl Heinz Wirsing von König
Studies of the incidence of pertussis in adults have shown that it accounts for only 5-15% cases of prolonged coughing. We assessed the burden of suffering related to prolonged coughing and tried to identify further causative agents. Based on a sentinel study with 35 general practitioners in two German cities (Krefeld, Rostock), with 3,946 patients fulfilling the inclusion criteria, we estimated the incidence of prolonged coughing in adults. In 975 of these outpatients, PCR and/or serology for adenovirus, Bordetella pertussis and B...
January 4, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29287931/flow-cytometry-analysis-of-cd64-cd18-cd11a-and-cd11b-in-four-children-with-bordetella-pertussis-infection-and-admitted-to-critical-care-new-biomarkers
#8
A García-Salido, A Serrano-González, A M de Azagra-Garde, M Nieto-Moro, G J Melen, M Ramírez-Orellana
No abstract text is available yet for this article.
December 26, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29287065/calmodulin-fishing-with-a-structurally-disordered-bait-triggers-cyaa-catalysis
#9
Darragh P O'Brien, Dominique Durand, Alexis Voegele, Véronique Hourdel, Marilyne Davi, Julia Chamot-Rooke, Patrice Vachette, Sébastien Brier, Daniel Ladant, Alexandre Chenal
Once translocated into the cytosol of target cells, the catalytic domain (AC) of the adenylate cyclase toxin (CyaA), a major virulence factor of Bordetella pertussis, is potently activated by binding calmodulin (CaM) to produce supraphysiological levels of cAMP, inducing cell death. Using a combination of small-angle X-ray scattering (SAXS), hydrogen/deuterium exchange mass spectrometry (HDX-MS), and synchrotron radiation circular dichroism (SR-CD), we show that, in the absence of CaM, AC exhibits significant structural disorder, and a 75-residue-long stretch within AC undergoes a disorder-to-order transition upon CaM binding...
December 29, 2017: PLoS Biology
https://www.readbyqxmd.com/read/29249756/-a-case-of-pertussis-in-adult-that-could-be-diagnosed-by-detection-of-bordetella-pertussis-from-sputum
#10
Ayano Usuba, Yuko Komase, Baku Oyama, Takahiro Tsuburai, Naoya Hida
Bordetella pertussis isolation by culture has low detection sensitivity for diagnosing pertussis; the diagnosis is confirmed by measuring serum anti-pertussis toxin (anti-PT) or anti-filamentous hemagglutinin antibody titers, and by genetic testing (polymerase chain reaction/loop-mediated isothermal amplification). Isolation of B. pertussis in adults is difficult, resulting in a delayed diagnosis, as a delayed cough may present ≥3 months after onset. Differentiation from bronchial asthma is also important...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29244973/cooperativity-between-antibiotics-and-antiseptics-testing-the-bactericidal-effect
#11
S Jenull, H Laggner, I Hassl, B Velimirov, M Huettinger, N Zemann
OBJECTIVE: Treatment with antibiotics together with local application of antiseptics is common in wound care. We investigated the effectiveness of an antiseptic in two variations: octenidine (Oct) and octenidine+ (Oct+ with isotonic glucose addition). METHOD: Using the agar diffusion test with cultures of pathogenic Staphylococcus aureus and the non-pathogenic Bordetella petrii, we compared the effectiveness of octenidine to the classical antiseptics beta-isodona (povidone-iodine; PI), chlorhexidine (Chl) and taurolin (Tau) alone, and in combination with various common antibiotics to uncover cooperativity between antiseptics and antibiotics...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29238457/molecular-detection-of-bordetella-holmesii-in-two-infants-with-pertussis-like-syndrome-the-first-report-from-iran
#12
Masoumeh Nakhost Lotfi, Vajiheh Sadat Nikbin, Omid Nasiri, Farzad Badmasti, Fereshteh Shahcheraghi
Background and Objectives: Bordetella holmesii is associated with a pertussis-like respiratory syndrome in healthy individuals and also a rare cause of septicaemia, endocarditis, pneumonia, and septic arthritis, mostly in immunocompromised patients. Culture technique and real-time PCR are 2 methods used to detect Bordetella spp. Materials and Methods: In this study, 435 nasopharyngeal specimens of patients with suspected whooping cough were checked for the presence of B...
August 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29237995/recovery-of-bordetella-bronchiseptica-sequence-type-82-and-b-pseudohinzii-from-urban-rats-in-terengganu-malaysia
#13
Shih Keng Loong, Nurul-Asma-Anati Che-Mat-Seri, Osama Abdulrazak, Benacer Douadi, Siti-Noraisah Ahmad-Nasrah, Jefree Johari, Siti-Nursheena Mohd-Zain, Sazaly Abubakar
Rodents have historically been associated with zoonotic pandemics that claimed the lives of large human populations. Appropriate pathogen surveillance initiatives could contribute to early detection of zoonotic infections to prevent future outbreaks. Bordetella species are bacteria known to cause mild to severe respiratory disease in mammals and, some have been described to infect, colonize and spread in rodents. There is a lack of information on the population diversity of bordetellae among Malaysian wild rodents...
December 13, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29235265/synthesis-of-%C3%AE-branched-acyclic-nucleoside-phosphonates-as-potential-inhibitors-of-bacterial-adenylate-cyclases
#14
Jan Frydrych, Jan Skácel, Markéta Šmídková, Helena Mertlíková-Kaiserová, Martin Dračínský, Ramachandran Gnanasekaran, Martin Lepšík, Monica Soto-Velasquez, Val J Watts, Zlatko Janeba
Inhibition of Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema factor (EF), the key virulence factors with adenylate cyclase (AC) activity, represents a potential method how to treat or prevent toxemia related to whooping cough and anthrax, respectively. A novel series of α-branched acyclic nucleoside phosphonates (ANPs) having a hemiaminal ether moiety was synthesized as potential inhibitors of bacterial adenylate cyclases. ANPs prepared as bisamidates were not cytotoxic but did not exhibited any profound activity (IC50 > 10 µM) towards ACT in J774A...
December 13, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29229084/serological-study-of-bordetella-pertussis-mycoplasma-pneumonia-and-chlamydia-pneumonia-in-iranian-hajj-pilgrims-with-prolonged-cough-illnesses-a-follow-up-study
#15
Masoud Rahimian, Mahdi HosseiniB
INTRODUCTION: Hajj pilgrimage is the biggest and longest mass gathering in the Muslim world. Annually, about 50% of more than 2.5 million pilgrims participating in this ritual get involved in severe devastating coughs. Most coughs continue, so the pilgrims turn back home and transmit them to family members and other people. Despite the high prevalence of coughs for many years, what causes them remains unknown. Considering the pertussis-like clinical picture of the so-called "hajj coughs", the researchers conducted a study to measure antibodies against three known common atypical bacteria, namely Bordetella Pertussis, Chlamydia Pneumonia and Mycoplasma Pneumonia...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29223471/-clinical-epidemiological-study-of-bordetella-pertussis-infection-in-the-gran-canaria-island-in-the-period-2008-2016
#16
Laura Iglesias, Antonio Casabella Pernas, Melisa Hernández Febles, Elena Colino Gil, Alicia Eisman Maraver, María José Pena López
OBJECTIVE: Describe the epidemiological and clinical pattern of Bordetella pertussis infection (whooping cough) among hospitalised infants less than one year-old in a paediatric hospital in Gran Canaria. PATIENTS AND METHODS: A retrospective review of the patient hospital records was performed, and recording only those with a microbiological diagnosis of pertussis infection detected using polymerase chain reaction, from January 2008 to December 2016. RESULTS: A total of 110 patients were identified, of which 105 (95...
December 6, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29221733/diagnostic-performance-of-commercial-serological-assays-measuring-bordetella-pertussis-igg-antibodies
#17
Giorgio Fedele, Pasqualina Leone, Stefania Bellino, Ilaria Schiavoni, Claudia Pavia, Tiziana Lazzarotto, Paola Stefanelli
Due to their specificity to B. pertussis antigens, immunoglobulin G (IgG) antibodies should be measured primarily for diagnosing pertussis. We compared the diagnostic performance of commercially available enzyme-linked immunosorbent assays (ELISAs) and chemiluminescent immunoassays (CLIAs) measuring IgG to B. pertussis antigens. An in-house ELISA with purified pertussis toxin (PT) was used as reference system. Commercial assays using PT only as coating antigen showed better performance as compared to those using a mixture of different antigens...
November 13, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29205867/nanomotion-detection-method-for-testing-antibiotic-resistance-and-susceptibility-of-slow-growing-bacteria
#18
María Ines Villalba, Petar Stupar, Wojciech Chomicki, Massimiliano Bertacchi, Giovanni Dietler, Laura Arnal, María Elena Vela, Osvaldo Yantorno, Sandor Kasas
Infectious diseases are caused by pathogenic microorganisms and are often severe. Time to fully characterize an infectious agent after sampling and to find the right antibiotic and dose are important factors in the overall success of a patient's treatment. Previous results suggest that a nanomotion detection method could be a convenient tool for reducing antibiotic sensitivity characterization time to several hours. Here, the application of the method for slow-growing bacteria is demonstrated, taking Bordetella pertussis strains as a model...
December 4, 2017: Small
https://www.readbyqxmd.com/read/29205108/contributions-of-the-hydrophobic-helix-2-of-the-bordetella-pertussis-cyaa-hemolysin-to-membrane-permeabilization
#19
Panchika Prangkio, Sirikran Juntapremjit, Melanie Koehler, Peter Hinterdorfer, Chanan Angsuthanasombat
Adenylate cyclase (CyaA) is one of the major virulence factors of Bordetella pertussis that plays a key role in whooping cough pathogenesis. A putative transmembrane helical hairpin (α2-loop-α3), encompassing residues 529-594 of CyaA hemolysin (CyaA-Hly) domain, was previously proposed to be crucially involved in hemolytic activity against target erythrocytes. Here, to gain more insight into membrane permeabilization of this toxin, synthetic peptides corresponding to this critical helical component, i.e. α2 (W528-G550), α3 (G568-R594) and α2-loop-α3 (W528-R594), were examined on various membrane models in comparison with the purified 130-kDa CyaA-Hly...
December 1, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29203545/bordetella-pertussis-adenylate-cyclase-toxin-disrupts-functional-integrity-of-bronchial-epithelial-layers
#20
Shakir Hasan, Nikhil Nitin Kulkarni, Arni Asbjarnarson, Irena Linhartova, Radim Osicka, Peter Sebo, Gudmundur H Gudmundsson
Airway epithelium restricts penetration of inhaled pathogens into the underlying tissue and plays a crucial role in innate immune defense against respiratory infections. The whooping cough agent, Bordetella pertussis, adheres to ciliated cells of human airway epithelium and subverts its defense functions through the action of secreted toxins and other virulence factors. We have examined the impact of B. pertussis infection and of adenylate cyclase toxin (CyaA) action on the functional integrity of air-liquid interface (ALI)-cultured human bronchial epithelial cells...
December 4, 2017: Infection and Immunity
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