keyword
MENU ▼
Read by QxMD icon Read
search

rcm

keyword
https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#1
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781266/total-synthesis-of-laingolide-b-stereoisomers-and-assignment-of-absolute-configuration
#2
Chengsen Cui, Wei-Min Dai
Total synthesis of (-)-(2 R,9 S)- and (+)-(2 S,9 S)-stereoisomers of laingolide B has been accomplished by using sequential ring-closing metathesis (RCM) and alkene isomerization to construct the macrocyclic trans- N-methyl enamide moiety. The Myers alkylation was used to secure the C2 stereochemistry of the two RCM precursors from a common (9 S)-C3-C9 alkyl iodide. The absolute configuration of laingolide B has been assigned as (2 S,9 R) by comparison of the optical rotation data.
May 21, 2018: Organic Letters
https://www.readbyqxmd.com/read/29780659/confocal-microscopy-in-skin-cancer
#3
REVIEW
Verena Ahlgrimm-Siess, Martin Laimer, Harold S Rabinovitz, Margaret Oliviero, Rainer Hofmann-Wellenhof, Ashfaq A Marghoob, Alon Scope
Purpose of Review: Reflectance confocal microscopy (RCM) enables imaging of skin lesions at cellular level resolution at the bedside (in vivo) or in freshly excised tissue (ex vivo). This article provides an overview of strengths and limitations of non-invasive RCM in skin cancer diagnosis. Recent Findings: RCM features of common melanocytic and non-melanocytic skin neoplasms such as melanoma, actinic keratosis/squamous cell carcinoma, basal cell carcinoma, and nevi have been well defined and show good correlation with dermoscopic and histopathologic findings...
2018: Current Dermatology Reports
https://www.readbyqxmd.com/read/29777282/ambulatory-intravenous-inotropic-support-and-or-levosimendan-in-pediatric-and-congenital-heart-failure-safety-survival-improvement-or-transplantation
#4
Sotiria C Apostolopoulou, George A Vagenakis, Alexandros Tsoutsinos, Felicia Kakava, Spyridon Rammos
End-stage heart failure (HF) frequently needs continuous inotropic support in hospital and has high morbidity and mortality in absence of heart transplantation. This study reports outcome, efficacy, and safety of continuous ambulatory inotropes (AI) and/or periodic levosimendan (LS) infusions in pediatric HF patients. The study included 27 patients, median age 9.4 (0.1-26.1) years, with severe HF (6 myocarditis, 13 dilated cardiomyopathy, 2 restrictive cardiomyopathy, 6 repaired congenital heart disease). Dobutamine and milrinone AI were administered in 21 patients through a permanent central catheter for median duration 1...
May 18, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29765972/reflectance-confocal-microscopy-as-new-diagnostic-tool-in-folliculotropic-mycosis-fungoides
#5
Gabriella Fabbrocini, Caterina Mazzella, Mariateresa Cantelli, Antonello Baldo, Daniela Russo, Gaetano De Rosa, Giuseppe Monfrecola
We present a case of folliculotropic mycosis fungoides (FMF), a variant of cutaneous T-cell lymphoma which particularly affects hair follicles. FMF can imitate a wide variety of otherwise benign dermatoses, so it poses major diagnostic obstacles both for the dermatologist as well as the dermatopathologist. In our case, in vivo reflectance confocal microscopy (RCM) was very important for guiding the skin biopsy site selection. For this reason, RCM can reduce the number of unsuccessful histopathological examinations and increase the diagnostic accuracy for different skin dermatoses...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29763511/a-review-of-non-invasive-imaging-in-extramammary-paget-s-disease
#6
REVIEW
Claire-Audrey Y Bayan, Trisha Khanna, Veronica Rotemberg, Faramarz H Samie, Nathalie C Zeitouni
Extramammary Paget's Disease (EMPD) is a rare intraepithelial adenocarcinoma that classically manifests with pruritic, erythematous, scaling plaques. The clinical picture frequently mimics inflammatory or infectious conditions, and is thus commonly misdiagnosed. The assessment of tumor margins is equally challenging as tumors have a propensity to spread beyond clinically visible boundaries. Appropriate non-invasive diagnostic tools can assist in the early detection, diagnosis, and management of EMPD. This paper will review the literature on non-invasive imaging modalities used in EMPD...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29752868/comparison-between-reflectance-confocal-microscopy-and-two-photon-microscopy-in-early-detection-of-cutaneous-radiation-injury-in-a-mouse-model-in-vivo
#7
Won Hyuk Jang, Soonjae Kwon, Sehwan Shim, Won-Suk Jang, Jae Kyung Myung, Sejung Yang, Sunhoo Park, Ki Hean Kim
Cutaneous radiation injury (CRI) is a skin injury caused by high dose exposure of ionizing radiation (IR). For proper treatment, early detection of CRI before clinical symptoms is important. Optical microscopic techniques such as reflectance confocal microscopy (RCM) and two-photon microscopy (TPM) have been tested as the early diagnosis method by detecting cellular changes. In this study, RCM and TPM were compared in the detection of cellular changes caused by CRI in an in-vivo mouse model. CRI was induced on the mouse hindlimb skin with various IR doses and the injured skin regions were imaged longitudinally by both modalities until the onset of clinical symptoms...
May 12, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29745452/efficacy-of-a-shower-cream-and-a-lotion-with-skin-identical-lipids-in-healthy-subjects-with-atopic-dry-skin
#8
Enzo Berardesca, Susan Mortillo, Norma Cameli, Marco Ardigo, Maria Mariano
BACKGROUND: Atopic dermatitis is a chronic, pruritic inflammatory skin disease that adversely affects quality of life. AIMS: The current study evaluates the efficacy of a shower cream and a lotion, each with skin-identical lipids and emollients, in the treatment of atopic dry skin of subjects with a history of atopic condition. METHODS: In all, 40 healthy females with clinically dry skin on the lower legs were enrolled in the study and underwent 4 weeks of daily use of the shower cream and 2 additional weeks of both the shower cream and the body lotion...
May 10, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29741282/restrictive-cardiomyopathy-an-unusual-phenotype-of-a-lamin-a-variant
#9
Mark S Paller, Cindy M Martin, Mary Ella Pierpont
Most individuals with cardiomyopathy associated with variants of the LMNA (lamin A) gene present with cardiac conduction abnormalities followed by dilated cardiomyopathy and cardiac failure; some also have skeletal muscle weakness. In this report, an individual with restrictive cardiomyopathy presenting with conduction defects followed by cardiac dysfunction of a restrictive nature eventually requiring cardiac transplantation is described. Subsequently, progressive skeletal muscle weakness became evident. The finding of a new LMNA pathologic gene variant in this patient increases the options for genetic testing of individuals with restrictive cardiomyopathy...
May 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29725557/clinico-microbiological-profile-of-septic-diabetic-foot-with-special-reference-to-anaerobic-infection
#10
K Sasikumar, Chellappa Vijayakumar, Sadasivan Jagdish, Dharanipragada Kadambari, Nagarajan Raj Kumar, Rakhi Biswas, Subhash Chandra Parija
Introduction Diabetic foot infections are a major cause of non-traumatic amputations. The role of anaerobes in the prognosis of these infections is particularly unclear. This study was conducted with the aim of correlating microbiological profiles with clinical outcomes in these diabetic foot ulcer patients. Methodology This prospective observational study was done in a tertiary care centre in South India. All patients admitted with diabetic foot ulcers for two years were included in the study. Tissue biopsies were collected from the ulcer for aerobic and anaerobic cultures...
March 1, 2018: Curēus
https://www.readbyqxmd.com/read/29725529/non-invasive-imaging-of-actinic-cheilitis-and-squamous-cell-carcinoma-of-the-lip
#11
Mihai Lupu, Ana Caruntu, Constantin Caruntu, Daniel Boda, Liliana Moraru, Vlad Voiculescu, Alexandra Bastian
An early diagnosis is of overwhelming importance for the management and prognosis of mucocutaneous cancer. Actinic cheilitis (AC), defined by the clonal expansion of genomically unstable keratinocytes, is the most common potentially malignant lesion affecting the lips. Squamous cell carcinoma (SCC) is the most frequent oral malignancy, and there is strong evidence that the majority of the SCCs of the lip originate from AC. There is considerable difficulty in discerning between dysplasia and invasive carcinomas solely on a clinical basis...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29717365/the-who-diagnostic-criteria-for-polycythemia-vera-role-of-red-cell-mass-versus-hemoglobin-hematocrit-level-and-morphology
#12
Ljubomir Jakovic, Mirjana Gotic, Heinz Gisslinger, Ivan Soldatovic, Dijana Sefer, Mila Tirnanic, Danijela Lekovic, Maja Perunicic Jovanovic, Martin Schalling, Bettina Gisslinger, Christine Beham-Schmid, Ingrid Simonitsch-Klupp, Jürgen Thiele
Regarding diagnosis of polycythemia vera (PV), discussion persists about hemoglobin (Hb) and/or hematocrit (Hct) threshold values as surrogate markers for red cell mass (RCM) and the diagnostic impact of bone marrow (BM) morphology. We performed a retrospective study on 290 patients with PV (151 males, 139 females; median age 65 years) presenting with characteristic BM features (initial biopsies, centralized evaluation) and endogenous erythroid colony (EEC) formations. This cohort included (1) a group of 229 patients when following the 2008 versus 256 patients diagnosed according to the 2016 World Health Organization (WHO) guidelines, all presented with increased RCM; (2) masked PV patients with low Hb (n = 143)/Hct (n = 45) recruited from the 2008 WHO cohort; (3) a cohort of 17 PV patients with elevated diagnostic Hb/Hct levels but low RCM; and (4) nine PV patients with increased RCM, opposing low Hb/Hct values...
May 1, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29710577/from-global-circulation-to-local-flood-loss-coupling-models-across-the-scales
#13
Guido Felder, Juan José Gómez-Navarro, Andreas Paul Zischg, Christoph C Raible, Veronika Röthlisberger, Denica Bozhinova, Olivia Martius, Rolf Weingartner
Comprehensive flood risk modeling is crucial for understanding, assessing, and mitigating flood risk. Modeling extreme events is a well-established practice in the atmospheric and hydrological sciences and in the insurance industry. Several specialized models are used to research extreme events including atmospheric circulation models, hydrological models, hydrodynamic models, and damage and loss models. Although these model types are well established, and coupling two to three of these models has been successful, no assessment of a full and comprehensive model chain from the atmospheric to local scale flood loss models has been conducted...
April 23, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29704275/the-smart-approach-feasibility-of-lentigo-maligna-superficial-margin-assessment-with-handheld-reflectance-confocal-microscopy-technology
#14
G Pellacani, N De Carvalho, S Ciardo, B Ferrari, A M Cesinaro, F Farnetani, S Bassoli, P Guitera, P Star, R Rawson, E Rossi, C Magnoni, G Gualdi, C Longo, A Scope
BACKGROUND: Lentigo maligna may be challenging to clear surgically. OBJECTIVE: To evaluate feasibility of using superficial skin cuts as RCM imaging anchors for attaining negative surgical margins in lentigo maligna. METHODS: Included patients presented with lentigo maligna near cosmetically-sensitive facial structures. We evaluated, with handheld-RCM, microscopic clearance of melanoma beyond its dermoscopically-detected edges. Evaluated margins were annotated using shallow skin-cuts...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29701229/stable-ruthenium-olefin-metathesis-catalysts-bearing-symmetrical-nhc-ligands-with-primary-and-secondary-n-alkyl-groups
#15
Chiara Ambrosio, Veronica Paradiso, Chiara Costabile, Valerio Bertolasi, Tonino Caruso, Fabia Grisi
Four novel stable Hoveyda-Grubbs-type catalysts containing N,N'-dineopentyl- and N,N'-dicyclohexyl-substituted N-heterocyclic carbene (NHC) ligands with syn and anti phenyl groups on the ring backbone were synthesized and fully characterized. The catalytic potential of these complexes was investigated in metathesis reactions of both standard and renewable substrates. Compared to the Hoveyda-Grubbs second generation catalyst (HGII), all of the new catalysts showed high performances in most of the examined metathesis transformations...
April 27, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29700090/cardiac-amyloidosis
#16
Ana Martinez-Naharro, Philip N Hawkins, Marianna Fontana
Systemic amyloidosis comprises an uncommon group of disorders caused by the extracellular deposition of misfolded proteins in various organs. Cardiac amyloid deposition, causing an infiltrative/restrictive cardiomyopathy, is a frequent feature of amyloidosis and a major determinant of survival. It may be the presenting feature of the disease or may be identified while investigating a patient presenting with other organ involvement. The need for a high index of suspicion and the critical importance of precise biochemical typing of the amyloid deposits is paramount in light of recent therapeutic advances that can significantly improve prognosis...
April 1, 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29687567/dermoscopy-and-reflectance-confocal-microscopy-for-monitoring-the-treatment-of-actinic-cheilitis-with-ingenol-mebutate-gel-report-of-three-cases
#17
E Benati, R Pampena, C Bombonato, S Borsari, M Lombardi, C Longo
Actinic cheilitis (AC) can precede the development of squamous cell carcinoma (SCC) of the lip, a location with higher risk of invasiveness and metastasis. Herein, we reported the use of ingenol mebutate (IngMeb) 0.015% gel on three consecutive days to treat three patients suffering from AC. All the three patients achieved complete clearance of AC with rapid clinical effect, favorable safety profile, good patient's compliance related to short time of applications, and few local skin reactions. So IngMeb is an attractive new therapy for AC...
April 24, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29681957/mechanical-circulatory-support-is-effective-to-treat-pulmonary-hypertension-in-heart-transplant-candidates-disqualified-due-to-unacceptable-pulmonary-vascular-resistance
#18
Michał Zakliczyński, Jerzy Pacholewicz, Izabela Copik, Marcin Maruszewski, Tomasz Hrapkowicz, Roman Przybylski, Marian Zembala
Introduction: High pulmonary vascular resistance (PVR) in orthotopic heart transplantation (OHT) candidates is a risk factor of right ventricle failure after the procedure. However, the increase of PVR may be a consequence of the life-threatening deterioration of the left ventricle function. The use of mechanical circulatory support (MCS) seems to be the best solution, but it is reimbursed only in active OHT candidates. Aim: We performed a retrospective analysis of MCS effectiveness in maintaining PVR at values accepted for OHT...
March 2018: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/29664407/mechanical-circulatory-support-device-utilization-and-heart-transplant-waitlist-outcomes-in-patients-with-restrictive-and-hypertrophic-cardiomyopathy
#19
Lakshmi Sridharan, Brian Wayda, Lauren K Truby, Farhana Latif, Susan Restaino, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Paolo C Colombo, Mathew Maurer, Maryjane A Farr, Veli K Topkara
BACKGROUND: Patients with restrictive cardiomyopathy (RCM) and hypertrophic cardiomyopathy (HCM) generally are considered poor candidates for mechanical circulatory support devices (MCSDs) and often not able to be bridged mechanically to heart transplantation. This study characterized MCSD utilization and transplant waitlist outcomes in patients with RCM/HCM under the current allocation system and discusses changes in the era of the new donor allocation system. METHODS AND RESULTS: Patients waitlisted from 2006 to 2016 in the United Network for Organ Sharing registry were stratified by RCM/HCM versus other diagnoses...
March 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29627838/assessment-of-corneal-changes-associated-with-topical-antiglaucoma-therapy-using-in-vivo-confocal-microscopy
#20
Elmira Baghdasaryan, Tudor C Tepelus, Laura A Vickers, Ping Huang, Vikas Chopra, SriniVas R Sadda, Olivia L Lee
PURPOSE: Ocular surface disease (OSD) is highly prevalent in eyes treated with chronic, topical antiglaucoma (A/G) therapy. The purpose of this study was to utilize in vivo confocal microscopy (IVCM) to evaluate the corneal morphology, including characteristics of corneal epithelial cells, presence of epithelial dendritic cells (DCs), and characteristics of subbasal nerve plexus, of eyes under topical A/G therapy versus normal eyes. METHODS: Central corneal images were prospectively captured from 30 eyes of 16 patients under topical A/G therapy (>6 months) and 20 normal control eyes, using IVCM (HRT 3 RCM, Heidelberg, Germany)...
April 7, 2018: Ophthalmic Research
keyword
keyword
29409
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"