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https://www.readbyqxmd.com/read/29158087/fabp4-induces-asthmatic-airway-epithelial-barrier-dysfunction-via-ros-activated-foxm1
#1
Gaohui Wu, Liteng Yang, Yi Xu, Xiaohong Jiang, Xiaomin Jiang, Lisha Huang, Ling Mao, Shaoxi Cai
Functional abnormal airway epithelial cells, along with activated inflammatory cells, resulting in chronic airway inflammation, are considered as the characteristic of asthma. Fatty Acid Binding Protein 4 (FABP4) takes part in glucose and lipid homeostasis, and also have an important role in allergic airway inflammation. However, whether FABP4 influence barrier function of airway epithelial cells is unknown. In vivo, a HDM-induced murine model of asthma was obtained to assessed airway inflammation and protein expression of E-cadherin and Forkhead Box M1 (FoxM1)...
November 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29142812/left-ventricle-relative-apical-sparing-in-cardiac-amyloidosis
#2
Marianna Nardozza, Elisabetta Chiodi, Donato Mele
Amyloidosis is a disease characterized by the extracellular deposition of the protein amyloid. It is a multiorgan disease, and cardiac involvement is not uncommon, generally in the form of a restrictive cardiomyopathy. Typical aspects of cardiac amyloidosis have been described at echocardiography and magnetic resonance imaging (MRI). In particular, the relative apical sparing at two-dimensional speckle-tracking echocardiography has been reported to be specific for cardiac amyloidosis. In our case, we report for the first time that this echocardiographic sign is related to lack of hyperenhancement at late gadolinium enhancement imaging in cardiac MRI...
October 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29125708/integration-of-dermoscopy-and-reflectance-confocal-microscopy-for-distinguishing-melanomas-from-nevi-of-the-breast-area
#3
V D Mandel, C Bombonato, R Pampena, A Kyrgidis, S Borsari, E Benati, M Mirra, S Piana, G Pellacani, C Longo
BACKGROUND: Nevi of special sites encompass a class of benign lesions characterized by the presence of atypical clinical and histopathologic features that can be difficult to distinguish from melanoma. Dermoscopy and reflectance confocal microscopy may improve the clinical assessment of melanocytic lesions in order to avoid unnecessary excisions. OBJECTIVES: The aim of this study was to assess the value of specific dermoscopic and confocal criteria in distinguishing melanomas from nevi of the breast area...
November 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29121636/improving-diagnostic-sensitivity-of-combined-dermoscopy-and-reflectance-confocal-microscopy-imaging-through-double-reader-concordance-evaluation-in-telemedicine-settings-a-retrospective-study-of-1000-equivocal-cases
#4
A M Witkowski, J Łudzik, F Arginelli, S Bassoli, E Benati, A Casari, N De Carvalho, B De Pace, F Farnetani, A Losi, M Manfredini, C Reggiani, J Malvehy, G Pellacani
BACKGROUND: Reflectance confocal microscopy (RCM) is an imaging device that permits non-invasive visualization of cellular morphology and has been shown to improve diagnostic accuracy of dermoscopically equivocal cutaneous lesions. The application of double reader concordance evaluation of dermoscopy-RCM image sets in retrospective settings and its potential application to telemedicine evaluation has not been tested in a large study population. OBJECTIVE: To improve diagnostic sensitivity of RCM image diagnosis using a double reader concordance evaluation approach; to reduce mismanagement of equivocal cutaneous lesions in retrospective consultation and telemedicine settings...
2017: PloS One
https://www.readbyqxmd.com/read/29119609/conformational-bias-by-a-removable-silyl-group-construction-of-bicyclo-n-3-1-alkenes-via-ring-closing-metathesis
#5
Minggui Lin, Pei-Jun Cai, Zhixiong Zeng, Na Lin, Yang Shen, Bin Tang, Fan Li, Chen Chen, Zhi-Xiang Yu, Yandong Zhang
We herein report a novel strategy based on a conformationally controlled RCM by a removable silyl group, which allows the facile synthesis of various bicyclo[n.3.1]alkenes, especially a set of highly strained bicyclo[5.3.1]alkenes. Further derivatizations of the silyl group and the resultant double bond of bicyclo[5.3.1]undecene 2f enabled a concise synthesis of A-B-C ring skeleton of taxol. Density functional theory (DFT) calculations suggest that the introduction of a bulky silyl group at C-5 position of the 1,3-dialkenylcyclohexanol substrates dramatically lowers the energy bias gap between diaxial conformers (to RCM) and diequatorial conformers (to cross metathesis), thereby favoring the expected RCM reaction to give the challenging bridged molecules...
November 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29115737/reinterpreting-dermoscopic-pigment-network-with-reflectance-confocal-microscopy-for-identification-of-melanoma-specific-features
#6
B De Pace, F Farnetani, A Losi, S Ciardo, N De Carvalho, Anna M Cesinaro, L Reggiani Bonetti, J Chester, S Kaleci, E Del Duca, Steven P Nisticò, C Longo, G Pellacani
BACKGROUND: Pigment network is an important dermoscopic features for melanocytic lesions but alterations in grid line thickness are also observed in melanomas. OBJECTIVE: To investigate features of thick, thin and mixed pigment networks at dermoscopy and their respective features at Reflectance Confocal Microscopy (RCM) for differential diagnosis, correlated with histology METHODS: All melanocytic lesions with histological diagnosis, evaluated between January 2010 - May 2014, were enrolled and classified according to dermoscopy evaluation of the pigment network; thin, thick and mixed...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29102650/safety-and-feasibility-of-atrial-fibrillation-ablation-using-amigo-%C3%A2-system-versus-manual-approach-a-pilot-study
#7
Antonio Scarà, Luigi Sciarra, Ermenegildo De Ruvo, Alessio Borrelli, Domenico Grieco, Zefferino Palamà, Paolo Golia, Lucia De Luca, Marco Rebecchi, Leonardo Calò
BACKGROUND: The Amigo(®) Remote Catheter System is a relatively new robotic system for catheter navigation. This study compared feasibility and safety using Amigo (RCM) versus manual catheter manipulation (MCM) to treat paroxysmal atrial fibrillation (PAF). Contact force (CF) and force-time integral (FTI) values obtained during pulmonary vein isolation (PVI) ablation were compared. METHODS: Forty patients were randomly selected for either RCM (20) or MCM (20). All were studied with the Thermocool(®) SmartTouch(®) force-sensing catheter (STc)...
November 1, 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29093593/-duodenal-melanoma-a-case-report-and-review-of-the-literature
#8
Jorge Espinoza-Ríos, Yessenia Salas, Natalí Leiva Reyes, Ricardo Prochazka Zárate, Carlos García Encinas, Jaime Cok Garcia, José Pinto Valdivia, Eduar Bravo Paredes, Alejandro Bussalleu Rivera
We report the case of a male patient of 75 years old who presents with abdominal pain, hyporexia, early satiety, general malaise and watery stools, admitted in emergency for an episode of syncope. On physical examination, hepatomegaly of 6cm below the right costal margin was detected. CT scan showed multiple liver metastases. An upper endoscopy found multiple hyperpigmented lesions on the second portion of the duodenum. Histology and immunohistochemistry studies concluded it was duodenal melanoma. Skin and ocular examination did not reveal associated neoplastic lesions...
July 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29092435/nonlinear-wave-chaos-statistics-of-second-harmonic-fields
#9
Min Zhou, Edward Ott, Thomas M Antonsen, Steven M Anlage
Concepts from the field of wave chaos have been shown to successfully predict the statistical properties of linear electromagnetic fields in electrically large enclosures. The Random Coupling Model (RCM) describes these properties by incorporating both universal features described by Random Matrix Theory and the system-specific features of particular system realizations. In an effort to extend this approach to the nonlinear domain, we add an active nonlinear frequency-doubling circuit to an otherwise linear wave chaotic system, and we measure the statistical properties of the resulting second harmonic fields...
October 2017: Chaos
https://www.readbyqxmd.com/read/29080487/utilization-of-red-mud-and-pb-zn-smelter-waste-for-the-synthesis-of-a-red-mud-based-cementitious-material
#10
Yuan-Cheng Li, Xiao-Bo Min, Yong Ke, Li-Yuan Chai, Mei-Qing Shi, Chong-Jian Tang, Qing-Wei Wang, Yan-Jie Liang, Jie Lei, De-Gang Liu
A new method in which Pb/Zn smelter waste containing arsenic and heavy metals (arsenic sludge), red mud and lime are utilized to prepare red mud-based cementitious material (RCM) is proposed in this study. XRD, SEM, FTIR and unconfined compressive strength (UCS) tests were employed to assess the physicochemical properties of RCM. In addition, ettringite and iron oxide-containing ettringite were used to study the hydration mechanism of RCM. The results show that the UCS of the RCM (red mud+arsenic sludge+lime) was higher than that of the binder (red mud+arsenic sludge)...
October 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29055164/reflectance-confocal-microscopy-identification-of-subclinical-basal-cell-carcinomas-during-and-after-vismodegib-treatment
#11
Caroline Couzan, Elisa Cinotti, Bruno Labeille, Paul Vercherin, Pietro Rubegni, Frédéric Cambazard, Jean Luc Perrot
BACKGROUND: Recently, it has been shown that reflectance confocal microscopy (RCM) could identify subclinical basal cell carcinoma (BCC) during vismodegib treatment of locally-advanced BCC. OBJECTIVES: To evaluate specificity and sensitivity of clinical, dermoscopic and RCM examination for BCC in patients with multiple BCCs treated by vismodegib. METHODS: 94 BCCs had 710 clinical, dermoscopic and RCM examinations during 72 weeks of vismodegib treatment...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29050444/treatment-of-ichthyosis-vulgaris-with-a-urea-based-emulsion-videodermatoscopy-and-confocal-microscopy-evaluation
#12
Clara Benintende, Simona Boscaglia, Franco Dinotta, Francesco Lacarrubba, Giuseppe Micali
BACKGROUND: Ichthyosis vulgaris is a common disorder of keratinization caused by mutations in the filaggrin gene and clinically characterized by variable degree of xerosis. METHODS: Five patients affected by ichthyosis vulgaris and moderate to severe xerosis of the lower limbs, were treated twice daily for 30 days with an emulsion containing 10% urea, ceramides, and natural moisturizing factors (NMF). Evaluation was performed at baseline and at the end of treatment by clinical examination, Visual Analogue Scale to quantify itch, videodermatoscopy (VD), and reflectance confocal microscopy (RCM)...
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29049429/correlation-of-handheld-reflectance-confocal-microscopy-with-radial-video-mosaicing-for-margin-mapping-of-lentigo-maligna-and-lentigo-maligna-melanoma
#13
Oriol Yélamos, Miguel Cordova, Nina Blank, Kivanc Kose, Stephen W Dusza, Erica Lee, Milind Rajadhyaksha, Kishwer S Nehal, Anthony M Rossi
Importance: The management of lentigo maligna (LM) and LM melanoma (LMM) is challenging because of extensive subclinical spread and its occurrence on cosmetically sensitive areas. Reflectance confocal microscopy (RCM) improves diagnostic accuracy for LM and LMM and can be used to delineate their margins. Objectives: To evaluate whether handheld RCM with radial video mosaicing (HRCM-RV) offers accurate presurgical assessment of LM and LMM margins. Design, Setting, and Participants: This prospective study included consecutive patients with biopsy-proven LM and LMM located on the head and neck area who sought consultation for surgical management from March 1, 2016, through March 31, 2017, at the Dermatology Service of the Memorial Sloan Kettering Cancer Center...
October 11, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29044520/quercetin-protects-against-radiocontrast-medium-toxicity-in-human-renal-proximal-tubular-cells
#14
Michele Andreucci, Teresa Faga, Antonio Pisani, Raffele Serra, Domenico Russo, GIovambattista De Sarro, Ashour Michael
Radiocontrast media (RCM)-induced acute kidney injury (CI-AKI) is a major clinical problem whose, pathophysiology is not well understood. Direct toxic effects on renal cells, possibly mediated by reactive oxygen species, have been postulated as contributing to CI-AKI. We investigated the effect of quercetin on human renal proximal tubular (HK-2) cells treated with the radiocontrast medium (RCM) sodium diatrizoate. Quercetin is the most widely studied flavonoid, and the most abundant flavonol present in foods...
October 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29032001/efficacy-of-self-retained-cryopreserved-amniotic-membrane-for-treatment-of-neuropathic-corneal-pain
#15
Melina I Morkin, Pedram Hamrah
PURPOSE: Treatment of neuropathic corneal pain (NCP) remains intricate, and involves a long-term combined multistep approach. The self-retained cryopreserved amniotic membrane (PROKERA(®), Bio-Tissue, Miami,FL) has been utilized for multiple ocular surface disorders. We evaluate the efficacy, safety, and tolerability of ProKera(®) Slim [PKS] and ProKera(®) Clear [PKC] in the treatment of NCP. METHODS: Retrospective case series of 9 patients who received PKS/PKC for the acute treatment of NCP...
October 12, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29030302/mesenchymal-stem-cell-therapy-for-retro-corneal-membrane-a-clinical-challenge-in-full-thickness-transplantation-of-biosynthetic-corneal-equivalents
#16
Vijayalakshmi Rajendran, Magdalena Netuková, May Griffith, John V Forrester, Lucia Kuffová
Artificial corneas (keratoprostheses) and biosynthetic collagen-based corneal equivalents are surgical implants designed to ease the global burden of corneal blindness. However, keratoprostheses in many cases fail due to development of fibrous retro-corneal membranes (RCM). Fibrous membranes which develop in the anterior chamber after prosthesis implantation do so on a matrix of fibrin. This study investigated fibrin deposition and RCM formation after full-thickness collagen-based hydrogel implants and compared them with syngeneic and allogeneic corneal grafts in mice...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29027359/a-master-manipulator-with-a-remote-center-of-motion-kinematic-structure-for-a-minimally-invasive-robotic-surgical-system
#17
Hyunyoung Lee, Byungsik Cheon, Minho Hwang, Donghoon Kang, Dong-Soo Kwon
BACKGROUND: In robotic surgical systems, commercial master devices have limitations owing to insufficient workspace and lack of intuitiveness. To overcome these limitations, a remote-center-of-motion (RCM) master manipulator was proposed. METHODS: The feasibility of the proposed RCM structure was evaluated through kinematic analysis using a conventional serial structure. Two performance comparison experiments (peg transfer task and objective transfer task) were conducted for the developed master and Phantom Omni...
October 12, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29025547/contemporary-techniques-of-pericardiectomy-for-pericardial-disease
#18
REVIEW
Pouya Hemmati, Kevin L Greason, Hartzell V Schaff
Pericardiectomy is a potentially curative treatment for constrictive pericarditis. We use a median sternotomy and believe that adequate resection involves removal of the diaphragmatic pericardium and the anterior pericardium. Late outcomes depend on severity of right-sided heart failure preoperatively, the etiology of constrictive pericarditis, and adequate pericardial resection. Late results are excellent in patients with idiopathic disease or those with pericarditis secondary to prior cardiac operations. However, survival is reduced in those with radiation-induced constrictive pericarditis, primarily owing to additional secondary effects of radiation on cardiac valves, epicardial coronary arteries, and ventricular myocardium where fibrosis may cause associated restrictive cardiomyopathy...
November 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/28992800/antimalarial-induced-cardiomyopathy-a-systematic-review-of-the-literature
#19
K Tselios, M Deeb, D D Gladman, P Harvey, M B Urowitz
Background Antimalarials (AMs) are widely used in the treatment of connective tissue diseases. Their main side effect is retinal damage, while heart disease has been described in isolated cases. The aim of this study is to systematically review the existing literature on AM-induced cardiomyopathy (AMIC). Methods The PubMed database was searched for heart biopsy-confirmed AMIC cases. Information on demographics, clinical presentation, concomitant AM-related toxicity, cardiological investigations, treatment and outcome were collected...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28990140/comparison-of-expression-of-key-sporulation-solventogenic-and-acetogenic-genes-in-c-beijerinckii-nrrl-b-598-and-its-mutant-strain-overexpressing-spo0a
#20
J Kolek, M Diallo, M Vasylkivska, B Branska, K Sedlar, A M López-Contreras, P Patakova
The production of acetone, butanol and ethanol by fermentation of renewable biomass has potential to become a valuable industrial process. Mechanisms of solvent production and sporulation involve some common regulators in some ABE-producing clostridia, although details of the links between the pathways are not clear. In this study, we compare a wild-type (WT) Clostridium beijerinckii NRRL B-598 with its mutant strain OESpo0A, in which the gene encoding Spo0A, an important regulator of both sporulation and solventogenesis, is overexpressed in terms of solvent and acid production...
October 8, 2017: Applied Microbiology and Biotechnology
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