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https://www.readbyqxmd.com/read/28228523/vpx-overcomes-a-samhd1-independent-block-to-hiv-reverse-transcription-that-is-specific-to-resting-cd4-t-cells
#1
Hanna-Mari Baldauf, Lena Stegmann, Sarah-Marie Schwarz, Ina Ambiel, Maud Trotard, Margarethe Martin, Manja Burggraf, Gina M Lenzi, Helena Lejk, Xiaoyu Pan, Oliver I Fregoso, Efrem S Lim, Libin Abraham, Laura A Nguyen, Frank Rutsch, Renate König, Baek Kim, Michael Emerman, Oliver T Fackler, Oliver T Keppler
Early after entry into monocytes, macrophages, dendritic cells, and resting CD4 T cells, HIV encounters a block, limiting reverse transcription (RT) of the incoming viral RNA genome. In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) has been identified as a restriction factor, lowering the concentration of dNTP substrates to limit RT. The accessory lentiviral protein X (Vpx) proteins from the major simian immunodeficiency virus of rhesus macaque, sooty mangabey, and HIV-2 (SIVsmm/SIVmac/HIV-2) lineage packaged into virions target SAMHD1 for proteasomal degradation, increase intracellular dNTP pools, and facilitate HIV cDNA synthesis...
February 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28226355/-role-of-diagnostic-laparoscopy-in-the-treatment-plan-of-gastric-cancer
#2
Haojie Li, Qi Zhang, Ling Chen, Lingqiang Min, Xuefei Wang, Fenglin Liu, Yihong Sun
OBJECTIVE: To assess the clinical value of the diagnostic laparoscopy in choosing treatment strategies for patients with gastric cancer. METHODS: Retrospective analysis was performed on clinical and pathological data collected from 2 023 patients undergoing gastric cancer surgery in the Zhongshan Hospital of Fudan University from 2009 to 2014. All the patients were diagnosed as gastric cancer by endoscopic biopsy and staged by imaging examination before surgery...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28218469/diagnostic-accuracy-of-reflectance-confocal-microscopy-using-vivascope-for-detecting-and-monitoring-skin-lesions-a-systematic-review
#3
S J Edwards, G Osei-Assibey, R Patalay, V Wakefield, C Karner
BACKGROUND: Skin cancer is one of the most common cancers in the UK. Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy. AIM: To evaluate the diagnostic accuracy of the in vivo VivaScope(©) reflective confocal microscopy (RCM) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins...
February 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28214381/the-value-of-reflectance-confocal-microscopy-in-diagnosis-of-flat-pigmented-facial-lesions-a-prospective-study
#4
E Wurm, G Pellacani, C Longo, H P Soyer, S Gonzalez, R Hofmann-Wellenhof, V Ahlgrimm-Siess, P Guitera, C Sinz, H Kittler
BACKGROUND: Flat pigmented facial lesions are difficult to diagnose even with dermatoscopy. It is controversial how additional information obtained by in vivo reflectance confocal microscopy (RCM) impacts the diagnosis and management. OBJECTIVE: To examine what in vivo reflectance confocal microscopy of flat pigmented facial lesions adds to clinical examination using dermatoscopy including digital dermatoscopic monitoring. METHODS: We prospectively collected 70 cases of flat pigmented facial lesions and recorded diagnoses and management decisions by experts based on direct clinical examination aided by dermatoscopy including digital dermatoscopic monitoring and by remote experts who reviewed the corresponding confocal images...
February 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28208780/preparation-of-constrained-geometry-titanium-complexes-of-1-2-azasilinane-framework-for-ethylene-1-octene-copolymerization
#5
Seul Lee, Seung Soo Park, Jin Gu Kim, Chung Sol Kim, Bun Yeoul Lee
The Me₂Si-bridged ansa-Cp/amido half-metallocene, [Me₂Si(η⁵-Me₄C₅)(N(t)Bu)]TiCl₂, termed a "constrained-geometry catalyst (CGC)", is a representative homogeneous Ziegler catalyst. CGC derivatives with the [1,2]azasilinane framework, in which the amide alkyl substituent is joined by the Si-bridge, were prepared, and the catalytic performances of these species was studied. Me₄C₅HSi(Me)(CH₂CH=CH₂)-NH(C(R)(R')CH=CH₂) (R, R' = H or methyl; Me₄C₅H = tetramethylcyclopentadienyl) was susceptible to ring closure metathesis (RCM) when treated with Schrock's Mo-catalyst to afford -Si(Me₄C₅H)(Me)CH₂CH=CHC(R)(R')NH- containing a six-membered ring framework...
February 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28191689/non-invasive-skin-imaging-for-the-diagnosis-of-myiasis
#6
E Cinotti, B Labeille, F Cambazard, F Dupuis, P Rubegni, J L Perrot
A 52-year-old man presented with a painful ulceration of the scalp (Fig. 1a). He had returned from Guyana the previous week. Dermoscopic examination (FotoFinder Systems GmbH, Bad Birnbach, Germany) showed an intermittent dynamic aspect changing from a sanguineous roundish ulcer (Fig. 1b) to a peculiar roundish structure characterized by a yellowish peripheral ring and a central brownish part (Fig. 1c). High-definition optical coherence tomography (HD-OCT; Skintell(®) ; Agfa Gevaert, Antverpen, Belgium) showed a skin cavity (Fig...
February 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28191661/combined-in-vivo-reflectance-confocal-microscopy-and-digital-dermoscopy-for-follow-up-of-patients-at-high-risk-of-malignant-melanoma-a-prospective-case-series-study
#7
Uxúa Floristán Muruzábal, Reyes Gamo Villegas, Ana Pampín Franco, Fernando Pinedo Moraleda, Elia Pérez Fernández, José Luis López-Estebaranz
Digital dermoscopy (DD) follow up is a useful strategy for monitoring patients at high risk of melanoma. Reflectance confocal microscopy (RCM) is a valuable second-level examination after dermoscopy for the evaluation of difficult to diagnose lesions. The aim of this study was to assess the value of RCM in routine DD monitoring of patients at high risk of melanoma. In this prospective study, performed over 22 months, changing melanocytic lesions were detected by DD and excised. RCM imaging was performed before surgical excision of all the lesions, and histopathology used as the gold standard diagnostic test...
February 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28186761/a-divergent-strategy-for-the-diastereoselective-synthesis-of-the-tricyclic-6-7-diaryl-tetrahydro-6h-benzo-c-chromene-core-via-pt-iv-catalyzed-cycloaddition-of-ortho-quinone-methides-and-olefin-ring-closing-metathesis
#8
Kassrin Tangdenpaisal, Kanokpish Chuayboonsong, Somsak Ruchirawat, Poonsakdi Ploypradith
A divergent strategy for the synthesis of the tricyclic 6,7-diaryl-tetrahydro-6H-benzo[c]-chromene core was successfully developed. The 2,3-trans 2,4-cis trisubstituted chroman moiety was formed via a highly efficient and stereoselective Pt(IV)-catalyzed cycloaddition reactions of the corresponding quinone methides with chalcones. Subsequent steps provided the common diene alcohol which underwent BF3.Et2O-mediated Et3SiH reduction and olefin ring-closing metathesis (RCM) using Ru(II) catalysts. The sequence of the final two steps provided a handle to diversify the stereochemical outcomes at C6 as well as C10a...
February 10, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28174160/novel-dominant-negative-mutation-in-cardiac-troponin-i-causes-severe-restrictive-cardiomyopathy
#9
Saumya Shah, Haran Yogasundaram, Ratnadeep Basu, Faqi Wang, David I Paterson, Tero-Pekka Alastalo, Gavin Y Oudit
No abstract text is available yet for this article.
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28163147/senile-cardiac-amyloidosis-clinical-manifestations-and-non-invasive-diagnostic-approach
#10
Dimitrios Varvarousis, Kali Polytarchou, Nikolaos Daskalopoulos, Ioannis Mantas
Cardiac amyloidosis (CA) refers to an uncommon storage disease leading to restrictive cardiomyopathy and conduction abnormalities. Survival is generally poor but depends strongly on the amyloid type. Wild type transthyretin amyloidosis or senile cardiac amyloidosis (SCA) is a disease of the >60-year age group, has a relatively better prognosis among the various amyloid types and is considered to be underdiagnosed. We describe a case of a patient with clinical signs and symptoms of restrictive cardiomyopathy and a suggested diagnosis of SCA and discuss the diagnostic and therapeutic approach...
February 2, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28160420/assessment-of-skin-pigmentation-by-confocal-microscopy-influence-of-solar-exposure-and-protection-habits-on-cutaneous-hyperchromias
#11
Ana Paula M Martini, Daiane G Mercurio, Patrícia M B G Maia Campos
BACKGROUND: Cutaneous hyperchromias are disorders of skin pigmentation involving an increase of melanin production and its irregular accumulation in skin cells. It is known that the use of sunscreens helps to prevent changes in the skin pigmentation pattern, but the structural and morphological alterations that occur in the different types of hyperpigmentations need better elucidation. OBJECTIVE: To assess the influence of solar exposure and protection habits on the pattern of skin pigmentation using reflectance confocal microscopy (RCM)...
February 3, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28148333/ethical-considerations-of-transparency-informed-consent-and-nudging-in-a-patient-with-paediatric-aortic-stenosis-and-symptomatic-left-ventricular-endocardial-fibroelastosis
#12
Constantine D Mavroudis, Thomas Cook, Jeffrey P Jacobs, Constantine Mavroudis
A 9-year-old boy who was born with bicuspid aortic stenosis underwent two unsuccessful aortic valvuloplasty interventions, and by 2 years of age he developed restrictive cardiomyopathy caused by left ventricular endocardial fibroelastosis and diastolic dysfunction. The attending cardiologist referred the patient to a high-volume, high-profile congenital cardiac surgical programme 1000 miles away that has a team with considerable experience with left ventricular endocardial fibroelastosis resection and a reputation of achieving good results...
December 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/28125000/an-adaptive-moving-target-imaging-method-for-bistatic-forward-looking-sar-using-keystone-transform-and-optimization-nlcs
#13
Zhongyu Li, Junjie Wu, Yulin Huang, Haiguang Yang, Jianyu Yang
Bistatic forward-looking SAR (BFSAR) is a kind of bistatic synthetic aperture radar (SAR) system that can image forward-looking terrain in the flight direction of an aircraft. Until now, BFSAR imaging theories and methods for a stationary scene have been researched thoroughly. However, for moving-target imaging with BFSAR, the non-cooperative movement of the moving target induces some new issues: (I) large and unknown range cell migration (RCM) (including range walk and high-order RCM); (II) the spatial-variances of the Doppler parameters (including the Doppler centroid and high-order Doppler) are not only unknown, but also nonlinear for different point-scatterers...
January 23, 2017: Sensors
https://www.readbyqxmd.com/read/28120817/re-scan-confocal-microscopy-rcm-improves-the-resolution-of-confocal-microscopy-and-increases-the-sensitivity
#14
Giulia De Luca, Ronald Breedijk, Ron Hoebe, Sjoerd Stallinga, Erik Manders
Re-scan confocal microscopy (RCM) is a new super-resolution technique based on a standard confocal microscope extended with a re-scan unit in the detection path that projects the emitted light onto a sensitive camera. In this paper the fundamental properties of RCM, lateral resolution, axial resolution and signal-to-noise ratio, are characterized and compared with properties of standard confocal microscopy. The results show that the lateral resolution of RCM is ~170 nm compared to ~240 nm of confocal microscopy for 488 nm excitation and 1...
January 25, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28120210/renin-angiotensin-system-gene-polymorphisms-as-potential-modifiers-of-hypertrophic-and-dilated-cardiomyopathy-phenotypes
#15
Bindu Rani, Amit Kumar, Ajay Bahl, Rajni Sharma, Rishikesh Prasad, Madhu Khullar
The renin-angiotensin (RAS) pathway has an important role in the etiology of heart failure and given the importance of RAS as a therapeutic target in various cardiomyopathies, genetic polymorphisms in the RAS genes may modulate the risk and severity of disease in cardiomyopathy patients. In the present study, we examined the association of RAS pathway gene polymorphisms, angiotensin converting enzyme (ACE), angiotensinogen (AGT), and angiotensin receptor type 1 (AGTR1) with risk and disease severity in Asian Indian idiopathic cardiomyopathy patients...
March 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28113504/a-marked-poisson-process-driven-latent-shape-model-for-3d-segmentation-of-reflectance-confocal-microscopy-image-stacks-of-human-skin
#16
Sindhu Ghanta, Michael I Jordan, Kivanc Kose, Dana H Brooks, Milind Rajadhyaksha, Jennifer G Dy
Segmenting objects of interest from 3D datasets is a common problem encountered in biological data. Small field of view and intrinsic biological variability combined with optically subtle changes of intensity, resolution and low contrast in images make the task of segmentation difficult, especially for microscopy of unstained living or freshly excised thick tissues. Incorporating shape information in addition to the appearance of the object of interest can often help improve segmentation performance. However, shapes of objects in tissue can be highly variable and design of a flexible shape model that encompasses these variations is challenging...
October 5, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28098235/molecular-characterization-of-pediatric-restrictive-cardiomyopathy-from-integrative-genomics
#17
Tara N Rindler, Robert B Hinton, Nathan Salomonis, Stephanie M Ware
Pediatric restrictive cardiomyopathy (RCM) is a genetically heterogeneous heart disease with limited therapeutic options. RCM cases are largely idiopathic; however, even within families with a known genetic cause for cardiomyopathy, there is striking variability in disease severity. Although accumulating evidence implicates both gene expression and alternative splicing in development of dilated cardiomyopathy (DCM), there have been no detailed molecular characterizations of underlying pathways dysregulated in RCM...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28080919/restrictive-cardiomyopathy-and-secondary-congestive-heart-failure-in-a-mcdowell-s-carpet-python-morelia-spilota-mcdowelli
#18
Lionel Schilliger, Valérie Chetboul, Cécile Damoiseaux, Alexandra Nicolier
Echocardiography is an established and noninvasive diagnostic tool used in herpetologic cardiology. Various cardiac lesions have been previously described in reptiles with the exception of restrictive cardiomyopathy. In this case report, restrictive cardiomyopathy and congestive heart failure associated with left atrial and sinus venosus dilation were diagnosed in a 2-yr-old captive lethargic McDowell's carpet python ( Morelia spilota mcdowelli), based on echocardiographic, Doppler, and histopathologic examinations...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28072629/the-key-clues-to-reach-the-diagnosis-of-loeffler-endomyocardial-fibrosis-associated-with-eosinophilic-granulomatosis-with-polyangiitis
#19
Enrico Ammirati, Domenico Sirico, Linda Brevetti, Laura Scudiero, Diana Artioli, Patrizia Pedrotti, Maria Frigerio
Loeffler endomyocardial fibrosis is a rare restrictive cardiomyopathy due to chronic eosinophilic exposure (Loeffler endomyocarditis). Loeffler endomyocarditis is associated with different eosinophilic disorders, including eosinophilic granulomatosis with polyangiitis (EGPA). These images recapitulate all typical findings that can be observed in patients presenting with heart failure attributable to this specific cardiomyopathy associated with EGPA, a systemic medical condition that can be easily detectable just putting together different diagnostic elements...
January 7, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28068669/kinetically-e-selective-macrocyclic-ring-closing-metathesis
#20
Xiao Shen, Thach T Nguyen, Ming Joo Koh, Dongmin Xu, Alexander W H Speed, Richard R Schrock, Amir H Hoveyda
Macrocyclic compounds are central to the development of new drugs, but preparing them can be challenging because of the energy barrier that must be surmounted in order to bring together and fuse the two ends of an acyclic precursor such as an alkene (also known as an olefin). To this end, the catalytic process known as ring-closing metathesis (RCM) has allowed access to countless biologically active macrocyclic organic molecules, even for large-scale production. Stereoselectivity is often critical in such cases: the potency of a macrocyclic compound can depend on the stereochemistry of its alkene; alternatively, one isomer of the compound can be subjected to stereoselective modification (such as dihydroxylation)...
January 19, 2017: Nature
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