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https://www.readbyqxmd.com/read/28430732/noninvasive-rcm-for-differentiation-of-melanotic-macules-from-melanocytic-lesions-blinded-evaluation-of-a-series-of-42-pigmented-macules
#1
Martin Laimer, Edith Arzberger, Clara-Anna Kirchner, Christine Prodinger, Rainer Hofmann-Wellenhof, Verena Ahlgrimm-Siess
BACKGROUND: Differentiation of melanotic macules from melanocytic lesions, most importantly of melanoma, is a common problem on clinical-dermoscopic examination. OBJECTIVE: To assess the value of noninvasive reflectance confocal microscopy (RCM) in the differential diagnosis of melanotic macules and melanocytic lesions. PATIENTS AND METHODS: Reflectance confocal microscopy images of 42 pigmented macules on mucocutaneous junctions of genitalia and lips, including 31 melanotic macules, 6 nevi, and 5 melanomas, were retrospectively and independently assessed in a blinded manner by one expert observer and 2 less experienced observers together...
April 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28421174/utility-of-cardiovascular-magnetic-resonance-derived-wave-intensity-analysis-as-a-marker-of-ventricular-function-in-children-with-heart-failure-and-normal-ejection-fraction
#2
Hopewell N Ntsinjana, Robin Chung, Paolo Ciliberti, Vivek Muthurangu, Silvia Schievano, Jan Marek, Kim H Parker, Andrew M Taylor, Giovanni Biglino
OBJECTIVE: This study sought to explore the diagnostic insight of cardiovascular magnetic resonance (CMR)-derived wave intensity analysis to better study systolic dysfunction in young patients with chronic diastolic dysfunction and preserved ejection fraction (EF), comparing it against other echocardiographic and CMR parameters. BACKGROUND: Evaluating systolic and diastolic dysfunctions in children is challenging, and a gold standard method is currently lacking...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28420953/using-cochlear-microphonic-potentials-to-localize-peripheral-hearing-loss
#3
Karolina K Charaziak, Christopher A Shera, Jonathan H Siegel
The cochlear microphonic (CM) is created primarily by the receptor currents of outer hair cells (OHCs) and may therefore be useful for identifying cochlear regions with impaired OHCs. However, the CM measured across the frequency range with round-window or ear-canal electrodes lacks place-specificity as it is dominated by cellular sources located most proximal to the recording site (e.g., at the cochlear base). To overcome this limitation, we extract the "residual" CM (rCM), defined as the complex difference between the CM measured with and without an additional tone (saturating tone, ST)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28420758/the-foxm1-inhibitor-rcm-1-suppresses-goblet-cell-metaplasia-and-prevents-il-13-and-stat6-signaling-in-allergen-exposed-mice
#4
Lifeng Sun, Xiaomeng Ren, I-Ching Wang, Arun Pradhan, Yufang Zhang, Hannah M Flood, Bo Han, Jeffrey A Whitsett, Tanya V Kalin, Vladimir V Kalinichenko
Goblet cell metaplasia and excessive mucus secretion associated with asthma, cystic fibrosis, and chronic obstructive pulmonary disease contribute to morbidity and mortality worldwide. We performed a high-throughput screen to identify small molecules targeting a transcriptional network critical for the differentiation of goblet cells in response to allergens. We identified RCM-1, a nontoxic small molecule that inhibited goblet cell metaplasia and excessive mucus production in mice after exposure to allergens...
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28415467/poly-l-lactic-acid-and-polyurethane-nanofibers-fabricated-by-solution-blow-spinning-as-potential-substrates-for-cardiac-cell-culture
#5
Ewelina Tomecka, Michal Wojasinski, Elzbieta Jastrzebska, Michal Chudy, Tomasz Ciach, Zbigniew Brzozka
This paper presents a comparison and evaluation of cardiac cell proliferation on poly(l-lactic acid) (PLLA) and polyurethane (PU) nanofibrous mats fabricated by solution blow spinning (SBS). Three different cardiac cell lines: rat cardiomyoblasts (H9C2 line), human (HCM) and rat cardiomyocytes (RCM) were used for experiments. Cell morphology, orientation and proliferation were investigated on non-modified and protein-modified (fibronectin, collagen, gelatin, laminin, poly-l-lysine) surfaces of both types of nanofibers...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413192/secondary-structural-changes-of-intact-and-disulfide-bridges-cleaved-human-serum-albumins-in-thermal-denaturation-up-to-130%C3%A2-c-additive-effects-of-sodium-dodecyl-sulfate-on-the-changes
#6
Yoshiko Moriyama, Kunio Takeda
The secondary structural changes of human serum albumin with the intact 17 disulfide bridges (HSA) and the disulfide bridges-cleaved human serum albumin (RCM-HSA) in thermal denaturation were examined. Most of the helical structures of HSA, whose original helicity was 66%, were sharply disrupted between 50 and 100°C. However, 14% helicity remained even at 130°C. The temperature dependence of the degree of disrupted helical structures of HSA was discussed in connection with questions about a general protein denaturation model...
April 13, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28407059/septal-artery-diastolic-flow-profile-in-hypertrophic-restrictive-cardiomyopathy-doppler-square-root-sign
#7
Dhaval Desai, M Fuad Jan, Lindsey Kalvin, A Jamil Tajik
No abstract text is available yet for this article.
April 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28405937/new-cardiac-imaging-algorithms-to-diagnose-constrictive-pericarditis-versus-restrictive-cardiomyopathy
#8
REVIEW
Ahmad Mahmoud, Manish Bansal, Partho P Sengupta
PURPOSE OF REVIEW: Echocardiography is the mainstay in the diagnostic evaluation of constrictive pericarditis (CP) and restrictive cardiomyopathy (RCM), but no single echocardiographic parameter is sufficiently robust to accurately distinguish between the two conditions. The present review summarizes the recent advances in echocardiography that promise to improve its diagnostic performance for this purpose. The role of other imaging modalities such as cardiac computed tomography, magnetic resonance imaging, and invasive hemodynamic assessment in the overall diagnostic approach is also discussed briefly...
May 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28403262/combination-of-in-office-chemical-peels-with-a-topical-comprehensive-pigmentation-control-product-in-skin-of-color-subjects-with-facial-hyperpigmentation
#9
Jeanine Downie, Katie Schneider, Lisa Goberdhan, Elizabeth T Makino, Rahul C Mehta
<p>Dyschromia is one of the primary complaints for patients with skin of color. Treatments need to achieve a balance between tolerability and efficacy to address existing hyperpigmentation without causing additional damage that could trigger post-inflammatory hyperpigmentation (PIH). An open-label, single-center study was conducted to assess the efficacy of a novel comprehensive pigmentation control serum (LYT2) combined with a series of three very superficial chemical peels (VP) in skin of color subjects...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28399039/characterization-of-corneal-involvement-in-eyes-with-mucous-membrane-pemphigoid-by-in-vivo-confocal-microscopy
#10
Tudor C Tepelus, Jianyan Huang, SriniVas R Sadda, Olivia L Lee
PURPOSE: To describe the morphological features of the corneal epithelial layers, subbasal nerve plexus, stroma, and endothelium in patients with mucous membrane pemphigoid (MMP) as shown by in vivo confocal microscopy (IVCM). METHODS: Central corneal images were captured from 10 healthy age-matched control eyes and 30 eyes with clinically diagnosed MMP by in vivo laser scanning confocal microscopy (HRT III RCM). Morphological changes of the corneal epithelial layers, stroma, and endothelium, characteristics of corneal nerves, and presence of inflammatory dendritic cells (DCs) were evaluated...
April 10, 2017: Cornea
https://www.readbyqxmd.com/read/28391599/one-stop-shop-with-confocal-microscopy-imaging-versus-standard-care-for-surgical-treatment-of-basal-cell-carcinoma-an-open-label-non-inferiority-randomized-controlled-multicenter-trial
#11
D J Kadouch, Y S Elshot, B Zupan-Kajcovski, A S E van Haersma de With, A C van der Wal, M Leeflang, K Jóźwiak, A Wolkerstorfer, M W Bekkenk, P I Spuls, M A de Rie
BACKGROUND: Routine punch biopsies are considered as the standard care to diagnose and subtype basal cell carcinoma (BCC) when clinically suspected. OBJECTIVES: We assessed the efficacy of a one-stop-shop concept using in vivo reflectance confocal microscopy imaging (RCM) as diagnostic tool versus standard care for surgical treatment in patients with clinically suspected BCC. METHODS: In this open-label, parallel-group, non-inferiority, randomized controlled multicenter trial we enrolled patients with clinically suspected BCC at two tertiary referral centers in Amsterdam, the Netherlands...
April 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28382084/diverse-phenotypic-expression-of-cardiomyopathies-in-a-family-with-tnni3-p-arg145trp-mutation
#12
Ji-Won Hwang, Mi-Ae Jang, Shin Yi Jang, Soo Hyun Seo, Moon-Woo Seong, Sung Sup Park, Chang-Seok Ki, Duk-Kyung Kim
Genetic diagnosis of cardiomyopathies is challenging, due to the marked genetic and allelic heterogeneity and the lack of knowledge of the mutations that lead to clinical phenotypes. Here, we present the case of a large family, in which a single TNNI3 mutation caused variable phenotypic expression, ranging from restrictive cardiomyopathy (RCMP) to hypertrophic cardiomyopathy (HCMP) to near-normal phenotype. The proband was a 57-year-old female with HCMP. Examining the family history revealed that her elder sister had expired due to severe RCMP...
March 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28371863/hypercontractile-mutant-of-ventricular-myosin-essential-light-chain-leads-to-disruption-of-sarcomeric-structure-and-function-and-results-in-restrictive-cardiomyopathy-in-mice
#13
Chen-Ching Yuan, Katarzyna Kazmierczak, Jingsheng Liang, Rosemeire Kanashiro-Takeuchi, Thomas C Irving, Aldrin V Gomes, Yihua Wang, Thomas P Burghardt, Danuta Szczesna-Cordary
Aims: The E143K (Glu→Lys) mutation in the myosin essential light chain (ELC) has been associated with restrictive cardiomyopathy (RCM) in humans, but the mechanisms that underlie the development of defective cardiac function are unknown. Using transgenic E143K-RCM mice, we sought to determine the molecular and cellular triggers of E143K-induced heart remodeling. Methods and Results: The E143K-induced abnormalities in cardiac function and morphology observed by echocardiography and invasive hemodynamics were paralleled by augmented active and passive tension measured in skinned papillary muscle fibers compared with wild-type (WT)-generated force...
March 23, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28370434/diagnostic-accuracy-of-confocal-microscopy-imaging-versus-punch-biopsy-for-diagnosing-and-subtyping-basal-cell-carcinoma
#14
D J Kadouch, M M Leeflang, Y S Elshot, C Longo, M Ulrich, A C van der Wal, A Wolkerstorfer, M W Bekkenk, M A de Rie
BACKGROUND: In vivo reflectance confocal microscopy (RCM) is a promising non-invasive skin imaging technique that could facilitate early diagnosis of basal cell carcinoma (BCC) instead of routine punch biopsies. However, the clinical value and utility of RCM versus a punch biopsy in diagnosing and subtyping BCC is unknown. OBJECTIVE: To assess diagnostic accuracy of RCM versus punch biopsy for diagnosing and subtyping clinically suspected primary BCC. METHODS: A prospective, consecutive cohort of 100 patients with clinically suspected BCC were included at two tertiary hospitals in Amsterdam, the Netherlands, between February 3, 2015 and October 2, 2015...
April 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28364177/magnetic-resonance-imaging-for-characterizing-myocardial-diseases
#15
REVIEW
Maythem Saeed, Hui Liu, Chang-Hong Liang, Mark W Wilson
The National Institute of Health defined cardiomyopathy as diseases of the heart muscle. These myocardial diseases have different etiology, structure and treatment. This review highlights the key imaging features of different myocardial diseases. It provides information on myocardial structure/orientation, perfusion, function and viability in diseases related to cardiomyopathy. The standard cardiac magnetic resonance imaging (MRI) sequences can reveal insight on left ventricular (LV) mass, volumes and regional contractile function in all types of cardiomyopathy diseases...
March 31, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28356264/screening-of-the-filamin-c-gene-in-a-large-cohort-of-hypertrophic-cardiomyopathy-patients
#16
Juan Gómez, Rebeca Lorca, Julian R Reguero, César Morís, María Martín, Salvador Tranche, Belén Alonso, Sara Iglesias, Victoria Alvarez, Beatriz Díaz-Molina, Pablo Avanzas, Eliecer Coto
BACKGROUND: Recent exome sequencing studies identified filamin C (FLNC) as a candidate gene for hypertrophic cardiomyopathy (HCM). Our aim was to determine the rate of FLNC candidate variants in a large cohort of HCM patients who were also sequenced for the main sarcomere genes. METHODS AND RESULTS: A total of 448 HCM patients were next generation-sequenced (semiconductor chip technology) for the MYH7, MYBPC3, TNNT2, TNNI3, ACTC1, TNNC1, MYL2, MYL3, TPM1, and FLNC genes...
April 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28350959/mapping-of-drug-like-chemical-universe-with-reduced-complexity-molecular-frameworks
#17
Aleksejs Kontijevskis
The emergence of the DNA-encoded chemical libraries (DEL) field in the past decade has attracted the attention of the pharmaceutical industry as a powerful mechanism for the discovery of novel drug-like hits for various biological targets. Nuevolution Chemetics technology enables DNA-encoded synthesis of billions of chemically diverse drug-like small molecule compounds, and the efficient screening and optimization of these, facilitating effective identification of drug candidates at an unprecedented speed and scale...
April 12, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28321995/clinical-and-microbiological-efficacy-of-4-garcinia-mangostana-l-pericarp-gel-as-local-drug-delivery-in-the-treatment-of-chronic-periodontitis-a-randomized-controlled-clinical-trial
#18
Jaideep Mahendra, Little Mahendra, Priyadharshini Svedha, Sandhya Cherukuri, Georgios E Romanos
AIM: The aim of the present study was to assess the periodontal status of individuals and the presence of red complex microorganisms (RCM), such as Treponema denticola (Td), Porphyromonas gingivalis, and Tannerella forsythia in the subgingival tissues of periodontitis patients before and after the application of 4% mangostana gel (Garcinia mangostana [MGA]) as an adjunct to scaling and root planing (SRP). METHODS: Twenty-five patients (MGA group) were treated with SRP, and the subgingival application of mangostana gel was used as local drug delivery...
March 20, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28292236/microwave-assisted-olefin-metathesis-as-pivotal-step-in-the-synthesis-of-bioactive-compounds
#19
Koffi Sénam Etsè, Alice Ngendera, Ntumba Nelly Tshibalonza, Albert Demonceau, Lionel Delaude, Ileana Dragutan, Valerian Dragutan
Over the last two decades, olefin metathesis has emerged as a new avenue in the design of new routes for the synthesis of natural products and active pharmaceutical ingredients. In many cases, syntheses based on olefin metathesis strategies provide elegant routes in terms of increasing the overall yields, improving the synthesis scope, and decreasing the number of steps. On the other hand, over the last decade, microwave-assisted chemistry has experienced an incredible development, which rapidly opened new vistas in organic synthesis and in homogeneous catalysis...
March 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28289898/comparison-of-dermoscopy-and-reflectance-confocal-microscopy-for-the-diagnosis-of-malignant-skin-tumours-a-meta-analysis
#20
REVIEW
Yi-Quan Xiong, Shu-Juan Ma, Yun Mo, Shu-Ting Huo, Yu-Qi Wen, Qing Chen
PURPOSE: Dermoscopy and reflectance confocal microscopy (RCM) are non-invasive methods for diagnosis of malignant skin tumours. The aim of this study was to compare the accuracy of dermoscopy and RCM for the diagnosis of malignant skin tumours. METHODS: Systematic electronic literature searches were conducted to include PubMed, Medline, Embase, the Cochrane Library database, and Web of Science, up to 26 April 2016. Pooled additional detection rate (ADR), diagnostic accuracy, and 95% confidence intervals (CIs) were calculated using STATA and Meta-Disc analysis...
March 13, 2017: Journal of Cancer Research and Clinical Oncology
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