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Giorgia Grutter, Sara Alfieri, Giulio Calcagni, Maria Assunta Castelluzzo, Massimo Stefano Silvetti, Francesco Parisi, Fabrizio Drago
In OHT recipients, pathologic evaluation of the heart during acute rejection can show involvement of both the conduction system and the myocardium. We here describe the cases of a 9-year-old male with DCM and a 13-year-old female with RCM, who developed third-degree PAVB associated with acute rejection 36 months and 24 months after OHT, respectively. We conclude that PAVB could be considered an early sign of acute rejection after OHT in children who exhibit post-transplantation presyncope or syncope.
October 14, 2016: Pediatric Transplantation
Martina Ulrich, Susanne Lange-Asschenfeldt, Kresten Skak, Torsten Skov, Marie Louise Østerdal, Hans-Joachim Röwert-Huber, John Robert Zibert, Eggert Stockfleth
Ingenol mebutate represents a topical treatment for fields with actinic keratosis (AK). The biological effects of ingenol mebutate in AK, subclinical (SC)-AK, and reference-skin were assessed and graded by in vivo reflectance confocal microscopy (RCM) and histology. Patients with AK and SC-AK lesions in one 25 cm2 field on hands or forearms, and with an area of reference skin on the inner upper arm, were included. The two fields were each treated with ingenol mebutate 0.05% gel (n=16), or vehicle (n=8), on 2 consecutive days; clinical and RCM assessments were performed on days 1, 2, 3, 8, and 57, and biopsies on day 3...
October 1, 2016: Journal of Drugs in Dermatology: JDD
A Paganelli, S Ciardo, G Odorici, G Pellacani, A Conti
Pityriasis rubra pilaris (PRP) is a rare, chronic inflammatory skin disorder characterized by the presence of small follicular hyperkeratotic papules that coalesce into yellow-pink (salmon-colored) patches, usually beginning at the head and neck and often resulting in generalized erythroderma(1) . Other main clinical features are "islands" of sparing within the affected skin, palmoplantar keratoderma, nail dystrophy, oral involvement and eventually ectropion. The age of onset has a peak between 50 and 70 years but a juvenile presentation is not uncommon...
October 14, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Vincenzo Grassia, Enrica Gentile, Dario Di Stasio, Abdolreza Jamilian, Giovanni Matarese, Fabrizia D'Apuzzo, Rossella Santoro, Letizia Perillo, Rosario Serpico, Alberta Lucchese
After orthodontic treatment with fixed appliances, bonded brackets and residual adhesive must be removed. This procedure should lead to restitutio ad integrum of the enamel or, at least, restore the enamel surface as closely as possible to its pre-treatment conditions. The purpose of this study is the in vivo assessment at a microscopic resolution of enamel surfaces after bracket debonding while avoiding the tooth extraction. Nine orthodontic patients who had brackets removed at the conclusion of orthodontic treatment were enrolled...
October 13, 2016: Ultrastructural Pathology
William Lorne McClennan, Stephanie Alyssa Rufh, Justin Alexander MacDonald Lummiss, Deryn Elizabeth Fogg
Sterically accessible Lewis donors are shown to accelerate decomposition during catalysis, for a broad range of Grubbs-class metathesis catalysts. These include benzylidene derivatives RuCl2(NHC)(PCy3)(=CHPh) (Ru-2: NHC = H2IMes, a; IMes, b; H2IPr, c; IPr, d; H2ITol, e) and indenylidene complexes RuCl2(NHC)(PCy3)(=C15H10) (NHC = H2IMes, Ru-2f; IMes, Ru-2g). All of these precatalysts form methylidene complex RuCl2(NHC)(=CH2) Ru-3 as the active species in metathesis of terminal olefins, and generate RuCl2(NHC)(PCy3)(=CH2) Ru-4 as the catalyst resting state...
October 13, 2016: Journal of the American Chemical Society
Stephen P Best, Feng Wang, Mohammed Tauhidul Islam, Shawkat Islam, Dominique Appadoo, Ryan Mcevey Trevorah, Christopher Thomas Chantler
Distortion of dynamic molecules is shown to give a clear signature in the vibrational spectra which can be modelled in terms of the energy barrier and sensitivity of the vibrational modes to the reaction coordinate. The reaction coordinate method (RCM) utilises ab initio-calculated spectra of the molecule in its ground and transition states together with their relative energies to predict the temperature dependence of the vibrational spectra. DFT-calculated spectra of the eclipsed (D5h) and staggered (D5d) forms of ferrocene (Fc), and its deuteriated analogue, within RCM explain the IR spectra of in gas (350 K), solution (300 K), solid solution (7-300 K) and solid (7-300 K) states...
October 13, 2016: Chemistry: a European Journal
Sindhu Ghanta, Michael I Jordan, Kivanc Kose, Dana H Brooks, Milind Rajadhyaksha, Jennifer G Dy
Segmenting objects of interest from 3D datasets is a common problem encountered in biological data. Small field of view and intrinsic biological variability combined with optically subtle changes of intensity, resolution and low contrast in images make the task of segmentation difficult, especially for microscopy of unstained living or freshly excised thick tissues. Incorporating shape information in addition to the appearance of the object of interest can often help improve segmentation performance. However, shapes of objects in tissue can be highly variable and design of a flexible shape model that encompasses these variations is challenging...
October 5, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Nigel G Maher, Annalisa Solinas, Richard A Scolyer, Pascale Guitera
OBJECTIVE: To improve prebiopsy diagnostic accuracy and surgical management of pigmented appearing lesions on the lips, particularly melanoma, using in vivo reflectance confocal microscopy (RCM). STUDY DESIGN: Prospective case series over a 12-month period between 2015 and 2016. The setting was two specialist dermatology referral centers with expertise in confocal microscopy. The study population was a consecutive sample of patients with pigmentation of the lip for which the cause was uncertain clinically, whose differential diagnosis included melanoma, and who had undergone both in vivo RCM and subsequent biopsy...
August 24, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
David H Oh, Alya Dabbagh, James L Goodson, Peter M Strebel, Sanjita Thapa, Jagat Narain Giri, Sagar Ratna Shakya, Sudhir Khanal
In 2012, the Global Vaccine Action Plan* established a goal to achieve measles and rubella elimination in five of the six World Health Organization (WHO) regions (194 countries) by 2020 (1). Measles elimination strategies aim to achieve ≥95% coverage with 2 routine doses of measles-containing vaccine (2), and implement supplementary immunization activities (SIAs)(†) in settings where routine coverage is low or where there are subpopulations at high risk. To ensure SIA quality and to achieve ≥95% SIA coverage nationally, rapid convenience monitoring (RCM) is used during or immediately after SIAs (3,4)...
October 7, 2016: MMWR. Morbidity and Mortality Weekly Report
Emily J Guggenheim, Abdullah Khan, Jeremy Pike, Lynne Chang, Iseult Lynch, Joshua Z Rappoport
The potential for human exposure to manufactured nanoparticles (NPs) has increased in recent years, in part through the incorporation of engineered particles into a wide range of commercial goods and medical applications. NP are ideal candidates for use as therapeutic and diagnostic tools within biomedicine, however concern exists regarding their efficacy and safety. Thus, developing techniques for the investigation of NP uptake into cells is critically important. Current intracellular NP investigations rely on the use of either Transmission Electron Microscopy (TEM), which provides ultrahigh resolution, but involves cumbersome sample preparation rendering the technique incompatible with live cell imaging, or fluorescent labelling, which suffers from photobleaching, poor bioconjugation and, often, alteration of NP surface properties...
2016: PloS One
Eunice Song, Jane M Grant-Kels, Helen Swede, Jody L D'Antonio, Avery Lachance, Soheil S Dadras, Arni K Kristjansson, Katalin Ferenczi, Hanspaul S Makkar, Marti J Rothe
BACKGROUND: Several technologies have been developed to aid dermatologists in the detection of melanoma in vivo including dermoscopy, multispectral digital skin lesion analysis (MDSLA), and reflectance confocal microscopy (RCM). To our knowledge, there have been no studies directly comparing MDSLA and RCM. OBJECTIVE: We conducted a repeated measures analysis comparing the sensitivity and specificity of MDSLA and RCM in the detection of melanoma (n = 55 lesions from 36 patients)...
September 29, 2016: Journal of the American Academy of Dermatology
Josep Malvehy Guilera, Alicia Barreiro Capurro, Cristina Carrera Alvárez, Susana Puig Sardá
Reflectance confocal microscopy (RCM) allows the evaluation with superb accuracy of some skin tumors before, during, and after treatment. In clinical trials RCM has been shown to provide useful information for evaluation of efficacy of topical or systemic medication. With the recent introduction of handheld RCM a fast examination of the tumor can be done in minutes. In patients treated with surgery RCM plays a unique role to precisely map margins of the tumor in the skin surface and for the detection of subclinical recurrences...
October 2016: Dermatologic Clinics
Alexander Witkowski, Joanna Łudzik, H Peter Soyer
Reflectance confocal microscopy (RCM) is becoming more popular among dermatologists aiming to improve their bedside diagnostic accuracy and reduce unnecessary removal of benign cutaneous lesions. With increased interest in the field, limitation of experts, and dedicated training programs, telemedicine application to RCM (teleconfocal) helps to connect patients with experts at a distance. Diagnostic accuracy of store-and-forward telemedicine review of RCM images, patient safety, and cost-effectiveness are important considerations for proper acceptance and usage of the technology in the medical community...
October 2016: Dermatologic Clinics
Marco Ardigo, Marina Agozzino, Chiara Franceschini, Francesco Lacarrubba
Reflectance confocal microscopy (RCM) allows real-time, noninvasive microscopic view of the skin at nearly histologic resolution serially over time. RCM increases the sensibility and sensitivity of the diagnosis of skin tumours. RCM evaluates descriptive features of psoriasis, lupus erythematosus, contact dermatitis, and others. Three groups of optical histology have been described: psoriasiform, spongiotic, and interface dermatitis. In a multicenter study, RCM patterns of spongiotic, hyperkeratotic, and interface dermatitis have been analyzed and an algorithmic method of analysis for fast application in the clinical setting based on a multivariate analysis has been proposed...
October 2016: Dermatologic Clinics
Syril Keena T Que, Jane M Grant-Kels, Harold S Rabinovitz, Margaret Oliviero, Alon Scope
The clinical diagnosis of tumors on the curved surfaces of the face, around the eyes, and on the mucosal surfaces can be difficult, while biopsies and excisions can have functional and aesthetic consequences. To avoid unnecessary surgery, clinicians have been aiming to attain accurate noninvasive diagnosis of lesions at these sites. However, acquisition of high-quality images with dermoscopy and with traditional wide-probe reflectance confocal microscopy (WP-RCM) have been hampered with technical difficulties...
October 2016: Dermatologic Clinics
Cristina Carrera, Ashfaq A Marghoob
Reflectance confocal microscopy (RCM) together with dermoscopy enables improved differentiation of melanomas from most nevi. The resulting high sensitivity for detecting melanoma with RCM is complemented by a concomitant increased specificity, which results in the reduction of unnecessary biopsies of nevi. Although RCM can achieve high diagnostic accuracy for early melanoma detection, false-negative and false-positive cases of melanoma are occasionally encountered. This article reviews the essential clues and pitfalls for the diagnosis of melanoma via RCM and highlights the importance of evaluating RCM findings in light of the clinical scenario and dermoscopic features...
October 2016: Dermatologic Clinics
Syril Keena T Que, Jane M Grant-Kels, Caterina Longo, Giovanni Pellacani
The use of reflectance confocal microscopy (RCM) and other noninvasive imaging devices can potentially streamline clinical care, leading to more precise and efficient management of skin cancer. This article explores the potential role of RCM in cutaneous oncology, as an adjunct to more established techniques of detecting and monitoring for skin cancer, such as dermoscopy and total body photography. Discussed are current barriers to the adoption of RCM, diagnostic workflows and standards of care in the United States and Europe, and medicolegal issues...
October 2016: Dermatologic Clinics
(no author information available yet)
There could be a 'huge' shortage of midwives in England if professionals from other European Union countries cannot work in the NHS after Brexit, the Royal College of Midwives (RCM) predicts.
September 30, 2016: Nursing Management (Harrow)
Clediana Dantas Calixto, Jordana Kaline da Silva Santana, Evandro Bernardo de Lira, Patrícia Giulianna Petraglia Sassi, Raul Rosenhaim, Cristiane Francisca da Costa Sassi, Marta Maria da Conceição, Roberto Sassi
The potential of four regional microalgae species was evaluated in relation to their cell growth and biomass production when cultured in the following alternative media: bio-composts of fruit/horticultural wastes (HB), sugarcane waste and vinasse (VB) chicken excrements (BCE), raw chicken manure (RCM), and municipal domestic sewage (MDS). The cultures were maintained under controlled conditions and their growth responses, productivities, biochemical compositions, and the ester profiles of their biomasses were compared to the results obtained in the synthetic media...
December 2016: Bioresource Technology
Anna Kostareva, Artem Kiselev, Alexandra Gudkova, Goar Frishman, Andreas Ruepp, Dmitrij Frishman, Natalia Smolina, Svetlana Tarnovskaya, Daniel Nilsson, Anna Zlotina, Tatiana Khodyuchenko, Tatiana Vershinina, Tatiana Pervunina, Alexandra Klyushina, Andrey Kozlenok, Gunnar Sjoberg, Irina Golovljova, Thomas Sejersen, Eugeniy Shlyakhto
BACKGROUND: Cardiomyopathies represent a rare group of disorders often of genetic origin. While approximately 50% of genetic causes are known for other types of cardiomyopathies, the genetic spectrum of restrictive cardiomyopathy (RCM) is largely unknown. The aim of the present study was to identify the genetic background of idiopathic RCM and to compile the obtained genetic variants to the novel signalling pathways using in silico protein network analysis. PATIENTS AND METHODS: We used Illumina MiSeq setup to screen for 108 cardiomyopathy and arrhythmia-associated genes in 24 patients with idiopathic RCM...
2016: PloS One
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