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https://www.readbyqxmd.com/read/29456976/respiratory-viruses-in-febrile-neutropenic-patients-with-respiratory-symptoms
#1
Mohsen Meidani, Seyed Alireza Mirmohammad Sadeghi
Background: Respiratory infections are a frequent cause of fever in neutropenic patients, whereas respiratory viral infections are not frequently considered as a diagnosis, which causes high morbidity and mortality in these patients. Materials and Methods: This prospective study was performed on 36 patients with neutropenia who admitted to hospital were eligible for inclusion with fever (single temperature of >38.3°C or a sustained temperature of >38°C for more than 1 h), upper and lower respiratory symptoms...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456228/-suttonella-indologenes-peritonitis-in-a-patient-receiving-continuous-ambulatory-peritoneal-dialysis
#2
Nurhayat Ozkan Sevencan, Serkan Bakirdogen, Adem Adar, Burcak Kayhan
Suttonella indologenes is a Gram-negative, aerobic coccobacillus of Cardiobacteriaceae family and its natural habitat is the mucous membranes of the upper respiratory system. The literature includes limited number of case reports concerning fatal endocarditis due to infection in the prosthetic heart valves caused by the aforementioned microorganism. However, there is no information on extracardiac involvement due to this microorganism. Here, we present a peritonitis case caused by Suttonella indologenes in a patient receiving continuous ambulatory peritoneal dialysis...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29454844/the-epidemiology-of-febrile-illness-in-sub-saharan-africa-implications-for-diagnosis-and-management
#3
REVIEW
Michael J Maze, Quique Bassat, Nicholas A Feasey, Inácio Mandomando, Patrick Musicha, John A Crump
BACKGROUND: Fever is among the most common symptoms of people living in Africa, and clinicians are challenged by the similar clinical features of a wide spectrum of potential aetiologies. AIM: To summarise recent studies of fever aetiology in sub-Saharan Africa focusing on causes other than malaria. SOURCES: A narrative literature review by searching the MEDLINE database, and recent conference abstracts. CONTENT: Studies of multiple potential causes of fever are scarce, and for many participants the infecting organism remains unidentified, or multiple co-infecting microorganisms are identified, and establishing causation is challenging...
February 15, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29450988/salso-bromo-iodine-thermal-water-a-nonpharmacological-alternative-treatment-for-postnasal-drip-related-cough-in-children-with-upper-respiratory-tract-infections
#4
I La Mantia, G Ciprandi, A Varricchio, F Cupido, C Andaloro
Postnasal drip (PND)-related cough is a very common symptom in patients with upper respiratory tract infections (URTIs). At present, there is not a standard treatment for postnasal drip and postnasal drip-related cough. The aim of this pilot study was to evaluate the efficacy of a specific salso-bromo-iodine thermal water containing hyaluronic acid and grapefruit seed extract (SBI-H-GSE) comparing it with a normal saline solution in children with URTIs who refer PND-related symptoms. The study was randomized, single-blind, and controlled...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29450387/orbital-cellulitis-and-brain-abscess-rare-complications-of-maxillo-spheno-ethmoidal-rhinosinusitis
#5
Farah Constantin, Patricia-Alexandra Niculescu, Oana Petre, Daniel Balasa, Alexandru Tunas, Ioana Rusu, Mihai Lupascu, Cristiana Orodel
Sinus infections can be complicated by ocular infections and, in late phases, by brain parenchyma infection. The article debates the case of a 12-year-old patient suffering from paucisymptomatic maxillo-spheno-ethmoidal rhinosinusitis, which was later complicated by orbital cellulitis, ending with the development of a brain abscess. The treatment is complex, initially targeting the source of the infection through draining the collection by middle maxillary antrostomy and anterior posterior ethmoidectomy, then the ablation of the brain abscess and postoperatively with prolonged massive antibiotherapy...
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29449938/molecular-characteristics-and-successful-management-of-a-respiratory-syncytial-virus-outbreak-among-pediatric-patients-with-hemato-oncological-disease
#6
Claas Baier, Sibylle Haid, Andreas Beilken, Astrid Behnert, Martin Wetzke, Richard J P Brown, Corinna Schmitt, Ella Ebadi, Gesine Hansen, Thomas F Schulz, Thomas Pietschmann, Franz-Christoph Bange
Background: Respiratory syncytial virus (RSV) is responsible for upper and lower respiratory tract infection in adults and children. Especially immunocompromised patients are at high risk for a severe course of infection, and mortality is increased. Moreover RSV can spread in healthcare settings and can cause outbreaks. Herein we demonstrate the successful control and characteristics of a RSV outbreak that included 8 patients in our Department of Pediatric Hematology and Oncology. Methods: We performed an epidemiologic investigation and a molecular analysis of the outbreak strains...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29449526/raised-serum-levels-of-syndecan-1-cd138-in-a-case-of-acute-idiopathic-systemic-capillary-leak-syndrome-scls-clarkson-s-disease
#7
Ole Wilhelm Bøe, Kjell Sveen, Magne Børset, Kirk M Druey
BACKGROUND Systemic capillary leak syndrome (SCLS) (Clarkson's disease) is a rare disorder of unknown etiology, characterized by transient episodes of hypotension, and the microvascular leak of fluids into the peripheral tissues, resulting in edema. Between 80-90% of patients with SCLS have a concomitant monoclonal gammopathy. Although translational in vitro studies have implicated vascular endothelial barrier dysfunction in the etiology of SCLS, the etiology and disease associations in clinical cases remain unknown...
February 16, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29447223/virome-and-bacteriome-characterization-of-children-with-pneumonia-and-asthma-in-mexico-city-during-winter-seasons-2014-and-2015
#8
Jose A Romero-Espinoza, Yazmin Moreno-Valencia, Rodrigo H Coronel-Tellez, Manuel Castillejos-Lopez, Andres Hernandez, Aaron Dominguez, Angel Miliar-Garcia, Arturo Barbachano-Guerrero, Rogelio Perez-Padilla, Alejandro Alejandre-Garcia, Joel A Vazquez-Perez
BACKGROUND: Acute asthma exacerbations and pneumonia are important causes of morbidity and mortality in children and may coexist in the same children, although symptom overlap may lead to difficulties in diagnosis. Microbial and viral diversity and differential abundance of either may play an important role in infection susceptibility and the development of acute and chronic respiratory diseases. OBJECTIVES: To describe the virome and bacteriome present in the upper respiratory tract of hospitalized children with a clinical diagnosis of asthma and pneumonia during an acute exacerbation and an acute respiratory illness ARI episode respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29445999/the-s190r-mutation-in-the-hemagglutinin-protein-of-pandemic-h1n1-2009-influenza-virus-increased-its-pathogenicity-in-mice
#9
Yongkun Chen, Tian Bai, Wenfei Zhu, Rongbao Gao, Zhihong Deng, Yi Shi, Shumei Zou, Yiwei Huang, Xiyan Li, Fangcai Li, Zhaomin Feng, Tao Chen, Jing Yang, Dayan Wang, Lidong Gao, Yuelong Shu
Human influenza viruses preferentially bind to sialic acid-α2,6-galactose (SAα2,6Gal) receptors, which are predominant in human upper respiratory epithelia, whereas avian influenza viruses preferentially bind to SAα2,3Gal receptors. However, variants with amino acid substitutions around the receptor-binding sites of the hemagglutinin (HA) protein can be selected after several passages of human influenza viruses from patients' respiratory samples in the allantoic cavities of embryonated chicken eggs. In this study, we detected an egg-adapted HA S190R mutation in the pandemic H1N1 virus 2009 (pdmH1N1), and evaluated the effects of this mutation on receptor binding affinity and pathogenicity in mice...
February 10, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29432219/calcitonin-gene-related-peptide-pathway-mabs-and-migraine-prevention
#10
Koen Paemeleire, Antoinette MaassenVanDenBrink
PURPOSE OF REVIEW: Monoclonal antibodies (mAbs) targeting the calcitonin-gene-related peptide (CGRP) pathway have been developed for episodic and chronic migraine prevention, either through binding the CGRP ligand (eptinezumab, fremanezumab, galcanezumab) or the CGRP receptor (erenumab). We provide an update on published Phase 2 and Phase 3 trials, safety/tolerability data, pharmacokinetics and mechanism of action of these biologicals. RECENT FINDINGS: The efficacy data from Phase 2 trials are corroborated by those from published Phase 3 trials, with a multitude of publications expected in 2018...
February 9, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29427907/human-coronavirus-circulation-in-the-united-states-2014-2017
#11
Marie E Killerby, Holly M Biggs, Amber Haynes, Rebecca M Dahl, Desiree Mustaquim, Susan I Gerber, John T Watson
BACKGROUND: Human coronaviruses (HCoVs) -OC43, -229E, -NL63 and -HKU1 cause upper and lower respiratory tract infections. HCoVs are globally distributed and the predominant species may vary by region or year. Prior studies have shown seasonal patterns of HCoV species and annual variation in species prevalence but national circulation patterns in the US have not yet been described. OBJECTIVES: To describe circulation patterns of HCoVs -OC43, -229E, -NL63 and -HKU1 in the US...
January 31, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29424696/upper-respiratory-viral-infections-in-patients-with-haematological-malignancies-after-allogeneic-haematopoietic-stem-cell-transplantation-a-retrospective-study
#12
Erden Atilla, Didem Sahin, Pinar Ataca Atilla, Istar Dolapci, Alper Tekeli, Sinem Civriz Bozdag, Meltem Kurt Yuksel, Selami Kocak Toprak, Osman Ilhan, Onder Arslan, Muhit Ozcan, Gunhan Gurman, Pervin Topcuoglu
BACKGROUND: Community respiratory viruses (CRVs) are associated with upper respiratory viral infections (URI), pneumonia or life-threatening respiratory disease in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our aim is to demonstrate our URI experience related to CRVs after allo-HSCT. METHODS: From January 2013 to November 2015, 39 post allo-HSCT patients with acute URI symptoms were included to the study. We evaluated CRVs by multiplex PCR from nasopharyngeal wash and throat swabs...
February 9, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/29424435/diagnostic-performance-of-the-sofia%C3%A2-influenza-a%C3%A2-%C3%A2-b-fluorescent-immunoassay-in-adult-outpatients-in-northern-taiwan
#13
Jeng-How Yang, Po-Yen Huang, Shian-Sen Shie, Shuan Yang, Kuo-Chien Tsao, Tsu-Lan Wu, Ting-Shu Wu, Ching-Tai Huang
To evaluate the diagnostic performance of the Sofia influenza A + B fluorescent immunoassay (Sofia FIA), we performed a prospective study at the Chang Gung Memorial Hospital in Taiwan from January 2012 to December 2013. Patients who presented at out-patient clinics or the emergency department with influenza-like illness were included. Upper respiratory tract specimens were collected from oropharynx or nasopharynx. Performance of the Sofia FIA was compared to that of the Formosa One Sure Flu A/B Rapid Test...
February 9, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29423745/in-reply-to-commentary-to-endoscopic-and-clinical-benefits-of-hyaluronic-acid-in-children-with-chronic-adenoiditis-and-middle-ear-disease-by-zhengcai-lou
#14
S Torretta, P Marchisio, V Rinaldi, D Carioli, E Nazzari, L Pignataro
Some considerations will be expressed in consideration of the commentary previously published. In particular, we underline that no other medications were administered to the patients during the study period and any clinical evaluation was postponed in case of acute upper respiratory tract infection in the previous 14 days. We strongly advocate antibiotic treatment during any acute otitis media episode, and we agree that topically administered hyaluronic acid should be considered as a supporting treatment, "complementary to traditional therapies" in children with recurrent disease...
February 8, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29420099/ocular-complications-in-influenza-virus-infection
#15
Joanna Brydak-Godowska, Monika Turczyńska, Mariusz Przybyś, Lidia B Brydak, Dariusz Kęcik
PURPOSE: To describe a case series of ocular complications associated with upper respiratory tract infections. METHODS: Four patients aged 21-61 years (three females, one male) had confirmed ocular complications connected with a general upper respiratory tract infection with myalgia and fever. Ophthalmological examination, including a visual acuity test, a slit-lamp exam, intraocular pressure measurements, fluorescein and indocyanine green angiography, optical coherence tomography (OCT), and diagnostic tests for influenza were performed in the patients (RT-PCR, HAI)...
February 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29416543/neutralizing-antibodies-induced-by-gene-based-hydrodynamic-injection-have-a-therapeutic-effect-in-lethal-influenza-infection
#16
Tatsuya Yamazaki, Maria Nagashima, Daisuke Ninomiya, Akira Ainai, Akira Fujimoto, Isao Ichimonji, Hidekazu Takagi, Naoko Morita, Kenta Murotani, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura
The influenza virus causes annual epidemics and occasional pandemics and is thus a major public health problem. Development of vaccines and antiviral drugs is essential for controlling influenza virus infection. We previously demonstrated the use of vectored immune-prophylaxis against influenza virus infection. We generated a plasmid encoding neutralizing IgG monoclonal antibodies (mAbs) against A/PR/8/34 influenza virus (IAV) hemagglutinin (HA). We then performed electroporation of the plasmid encoding neutralizing mAbs (EP) in mice muscles and succeeded in inducing the expression of neutralizing antibodies in mouse serum...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29415501/peptide-based-membrane-fusion-inhibitors-targeting-hcov-229e-spike-protein-hr1-and-hr2-domains
#17
Shuai Xia, Wei Xu, Qian Wang, Cong Wang, Chen Hua, Weihua Li, Lu Lu, Shibo Jiang
Human coronavirus 229E (HCoV-229E) infection in infants, elderly people, and immunocompromised patients can cause severe disease, thus calling for the development of effective and safe therapeutics to treat it. Here we reported the design, synthesis and characterization of two peptide-based membrane fusion inhibitors targeting HCoV-229E spike protein heptad repeat 1 (HR1) and heptad repeat 2 (HR2) domains, 229E-HR1P and 229E-HR2P, respectively. We found that 229E-HR1P and 229E-HR2P could interact to form a stable six-helix bundle and inhibit HCoV-229E spike protein-mediated cell-cell fusion with IC50 of 5...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29408194/association-between-air-pollution-and-upper-respiratory-tract-infection-in-hospital-outpatients-aged-0-14-years-in-hefei-china-a-time-series-study
#18
Y R Li, C C Xiao, J Li, J Tang, X Y Geng, L J Cui, J X Zhai
OBJECTIVE: To investigate the association between air pollution and upper respiratory tract infection (URTI) in children aged 0-14 years in Hefei, China in 2014-2015. STUDY DESIGN: An ecological method (i.e. generalised additive model [GAM]) was used to explore the effects of air pollutants on paediatric hospital outpatients with URTI. METHODS: GAM was used to evaluate the lag effects (including lag0 to lag6, lag01 and lag06) between daily changes in particulate matter (PM10), fine particulate matter (PM2...
February 2, 2018: Public Health
https://www.readbyqxmd.com/read/29406595/tritrichomonas-foetus-and-mycoplasma-felis-coinfection-in-the-upper-respiratory-tract-of-a-cat-with-chronic-purulent-discharge
#19
Luca Pazzini, Linda Mugnaini, Francesca Mancianti, Lorenzo Ressel
A 5-year-old indoor male neutered Siamese cat was presented with clinical signs of sneezing and chronic bilateral purulent nasal discharge. Multiple nasal cavity swabs were submitted for bacterial cultures, Mycoplasma felis-DNA qPCR, and cytology. M felisqPCR was positive and cytomorphologic diagnosis was severe, acute, purulent, rhinitis with intralesional protozoal microorganisms consistent with a Trichomonas spp. Nested PCR (nPCR) confirmed the diagnosis of Tritrichomonas foetus. Systemic therapy with doxycycline for M felis and metronidazole for T foetus was started with remission of clinical signs within 2 weeks; however, symptoms relapsed shortly after therapy was discontinued...
February 6, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29405137/spectrum-of-infections-in-acute-febrile-illness-in-central-india
#20
Yogendra Pandurang Shelke, Vijayshri Suresh Deotale, Deepashri Laxmanrao Maraskolhe
INTRODUCTION: Infectious agent when enters in the host results in febrile illness. This may lead to increase in morbidity or even mortality in undiagnosed/untreated cases. There are many aetiological agents which lead to acute febrile illness. Among these aetiological agents, important is bacterial or viral aetiology. OBJECTIVE: The objective of this study is: (i) To know the aetiological agents responsible for acute undifferentiated febrile illness (AUFI) by serological test or by bacterial culture and (ii) To know the clinical profile of AUFI...
October 2017: Indian Journal of Medical Microbiology
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