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https://www.readbyqxmd.com/read/29220542/safety-and-efficacy-of-apremilast-through-104-weeks-in-patients-with-moderate-to-severe-psoriasis-who-continued-on-apremilast-or-switched-from-etanercept-treatment-findings-from-the-liberate-study
#1
K Reich, M Gooderham, A Bewley, L Green, J Soung, R Petric, J Marcsisin, J Cirulli, R Chen, V Piguet
BACKGROUND: Apremilast, an oral phosphodiesterase 4 inhibitor, has demonstrated efficacy in patients with moderate to severe psoriasis. OBJECTIVE: To evaluate long-term efficacy and safety of apremilast in biologic-naive patients with moderate to severe plaque psoriasis and safety of switching from etanercept to apremilast in the phase 3b LIBERATE trial. METHODS: Two hundred fifty patients were randomized to placebo, apremilast 30 mg BID, or etanercept 50 mg QW through Week 16; thereafter, all patients continued or switched to apremilast through Week 104 (extension phase)...
December 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29215298/echinacea-purpurea-protects-against-restraint-stress-induced-immunosuppression-in-balb-c-mice
#2
Seonyoung Park, Mak-Soon Lee, Sunyoon Jung, Seohyun Lee, Oran Kwon, Matthias Heinrich Kreuter, Tania Perrinjaquet-Moccetti, Bokkee Min, Seong Ho Yun, Yangha Kim
Echinacea purpurea has been widely used for the prevention and treatment of upper respiratory tract infections and the common cold. The restraint stress has been reported to suppress a broad spectrum of immune functions. The aim of this study was to investigate the protective effects of the pressed juice of E. purpurea (L.) Moench (EFLA®894; Echinacea) against restraint stress-induced immunosuppression in BALB/c mice. Echinacea significantly normalized the restraint stress-induced reduction in splenocyte proliferation and splenic natural killer (NK) cell activity (P < ...
December 7, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29212934/influenza-a-virus-reassortment-is-limited-by-anatomical-compartmentalization-following-co-infection-via-distinct-routes
#3
Mathilde Richard, Sander Herfst, Hui Tao, Nathan T Jacobs, Anice C Lowen
Exchange of gene segments through reassortment is a major feature of influenza A virus evolution and frequently contributes to the emergence of novel epidemic, pandemic and zoonotic strains. It has long been evident that viral diversification through reassortment is constrained by genetic incompatibility between divergent parental viruses. In contrast, the role of virus-extrinsic factors in determining the likelihood of reassortment has remained unclear. To evaluate the impact of such factors in the absence of confounding effects of segment mismatch, we previously reported an approach in which reassortment between wild-type (wt) and genetically tagged variant (var) viruses of the same strain is measured...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29211841/perioperative-benefit-and-outcome-of-thoracic-epidural-in-esophageal-surgery-a-clinical-review
#4
P Feltracco, A Bortolato, S Barbieri, E Michieletto, E Serra, A Ruol, S Merigliano, C Ori
Surgery for esophageal cancer is a highly stressful and painful procedure, and a significant amount of analgesics may be required to eliminate perioperative pain and blunt the stress response to surgery. Proper management of postoperative pain has invariably been shown to reduce the incidence of postoperative complications and accelerate recovery. Neuraxial analgesic techniques after major thoracic and upper abdominal surgery have long been established to reduce respiratory, cardiovascular, metabolic, inflammatory, and neurohormonal complications...
December 2, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29209716/vitamin-d-supplementation-and-upper-respiratory-tract-infections-in-children-reply
#5
Mary Aglipay, Jonathon L Maguire
No abstract text is available yet for this article.
December 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29209712/vitamin-d-supplementation-and-upper-respiratory-tract-infections-in-children
#6
Bruce L Davidson, Khalid Alansari
No abstract text is available yet for this article.
December 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29208027/animations-designed-to-raise-patient-awareness-of-prudent-antibiotic-use-patient-recall-of-key-messages-and-their-immediate-effect-on-patient-attitude
#7
Donna M Lecky, Harpal Dhillon, Neville Q Verlander, Cliodna A M McNulty
OBJECTIVES: This study aimed to determine if patients recalled key messages from antibiotic animations shown on digital displays in General Practice waiting rooms, and if watching them changed patients' immediate intentions to consult their GP for upper respiratory tract infections, seek antibiotics and self-care. RESULTS: The pre intervention focus group found the animations intergenerational, informative and educational. 3119 patients were observed in 3 GP practices during project team visits; 145 (4...
December 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29207751/does-azithromycin-and-cetirizine-combination-given-for-upper-respiratory-tract-infections-has-any-significant-effect-on-qtc
#8
Kishor Kumar Rajasekaran, Jayakumar Jeganathan, Pavan Manibettu Raghuram
Introduction: Azithromycin usage in patients with baseline cardiovascular risk is associated with increased risk of cardiovascular mortality, following which Food and Drug Administration (FDA) issued a black box warning regarding safety of azithromycin in patients with cardiovascular morbidity particularly with prolonged QTc. Cetirizine is a second generation anti histaminic and is found to be commonly used for Upper Respiratory Tract Infections (URIs) along with azithromycin on outpatient basis...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206747/safety-and-efficacy-of-atazanavir-powder-and-ritonavir-in-hiv-1-infected-infants-and-children-aged-from-3-months-to-11-years-the-prince-2-study
#9
Mark F Cotton, Afaaf Liberty, Indiana Torres-Escobar, Maria Isabel Gonzalez-Tome, Jurgen Lissens, Luna Zaru, Isabelle Klauck, Daniela Cambilargiu, Cheryl Pikora, Todd A Correll
BACKGROUND: Novel antiretroviral formulations that are palatable, safe, and effective are needed for infants and children. METHODS: PRINCE-2 is an ongoing clinical trial assessing safety, efficacy, and palatability of once-daily atazanavir powder formulation boosted with ritonavir (ATV+RTV) plus optimized dual NRTI therapy in ARV-naïve/experienced children with screening HIV-1 RNA ≥1000 copies/mL. Children aged 3 months to <11 years received ATV+RTV by 5 baseline weight bands: 5 to <10kg=150/80mg; 5 to <10kg=200/80mg; 10 to <15kg=200/80mg; 15 to <25kg=250/80mg; and 25 to <35kg=300/100mg...
December 4, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29206094/long-term-follow-up-and-outcome-in-patients-with-recurrent-respiratory-laryngeal-papillomatosis
#10
Eva Rye Rasmussen, Didde T Schnack, Andreas Schjellerup Jørkov, Anna Axelsson Raja, Caroline Holkmann Olsen, Preben Homøe
INTRODUCTION: Recurrent respiratory papillomatosis is characterized by wart-like lesions of the upper airway and is most frequently caused by human papillomavirus (HPV). The disease has significant impact on quality of life due to potential airway obstruction, dysphonia and the need for serial surgeries. The main objective of this study was to describe patient characteristics and long-term follow-up data in a Danish cohort with the disease. METHODS: The study was a longitudinal retrospective cohort-study using data from electronic medical records and a pathology database...
December 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29205419/community-pharmacists-leaders-for-antibiotic-stewardship-in-respiratory-tract-infection
#11
S Essack, J Bell, A Shephard
WHAT IS KNOWN AND OBJECTIVE: Hospital-based pharmacists are established antibiotic stewards, but the potential for community pharmacists is largely untapped. This commentary explores the potential leadership role of the community pharmacist in antibiotic stewardship using upper respiratory tract infection (URTI) as an example. COMMENT: Community pharmacists are well placed for antibiotic stewardship, possessing the capability (knowledge of medicines), opportunity (contact with prescribers and patients) and inherent commitment...
December 4, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29204301/human-infection-with-fusobacterium-necrophorum-without-jugular-venous-thrombosis-a-varied-presentation-of-lemierre-s-syndrome
#12
Muhammad Asim Rana, Yashwant Kumar, Abdullah Ali Lashari, Ahmed F Mady
Lemierre's syndrome is also known as postangina septicemia, which is commonly caused by Fusobacterium necrophorum also known as Necrobacillus and also by other microorganisms like Staphylococcus, Streptococcus, Peptostreptococcus, and Bacteroides. Though the disease starts as an upper respiratory tract infection, it may spread and cause thrombophlebitis of the internal jugular vein. It may present itself through cranial nerve palsy or sepsis involving distant organs like the lungs or bones. It is also known as forgotten disease because of its rarity...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29202565/the-efficacy-of-topical-hyaluronan-in-rhinosinusitis-a-systematic-review
#13
M Casale, P Vella, A Moffa, V Grimaldi, L Sabatino, V Rinaldi, M A Lopez, P Baptista, F Salvinelli
Rhinosinusitis is one of the most common inflammatory conditions of the nasal cavity and paranasal sinuses and is one of the most common causes of absence from work and for visits to the family doctor. The treatment strategy in both acute rhinosinusitis (ARS) and chronic rhinosinusitis (CRS) is to reduce the severity of the symptoms, minimize the duration of the disease and prevent complications. Topical therapy has become an important tool in otolaryngologists’ armamentarium for rhinosinusitis treatment. Recently, topical hyaluronic acid (HA), the major component of many extracellular matrices that promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration and angiogenesis, has been proposed for ARS and CRS adjuvant tool...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29200251/misdiagnosing-of-malaria-as-rti-decreased-after-introduction-of-rdts-in-rural-areas-of-kenya
#14
(no author information available yet)
BACKGROUND: Clinical presentation of malaria is highly variable and can be mistaken for number of other diseases, including respiratory tract diseases, which are associated with significant morbidity and mortality. However, presumptive management of fever as malaria can result in significant overdiagnosis, even in high-risk areas. Quality microscopy services for the diagnosis of malaria are not widely available in rural areas of Sub-Saharan Africa as well as in substandard conditions of low-income settings and the accuracy of microscopy is usually poor...
November 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29200249/decision-and-cost-analysis-of-empirical-antibiotic-therapy-of-acute-sinusitis-in-the-era-of-increasing-antimicrobial-resistance-do-we-have-an-additional-tool-for-antibiotic-policy-decisions
#15
(no author information available yet)
OBJECTIVE: No previous analyses have attempted to determine optimal therapy for upper respiratory tract infections on the basis of cost-minimization models and the prevalence of antimicrobial resistance among respiratory pathogens in Slovakia. This investigation compares macrolides and cephalosporines for empirical therapy and look at this new tool from the aspect of potential antibiotic policy decision-making process. METHODS: We employed a decision tree model to determine the threshold level of macrolides and cephalosporines resistance among community respiratory pathogens that would make cephalosporines or macrolides cost-minimising...
November 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29198841/-antimicrobial-susceptibility-in-isolates-of-streptococcus-equi-subsp-equi-from-buenos-aires-province-argentina
#16
Carla P Bustos, María J Marfil, Natalia S Lanza, Nora Guida
Streptococcus equi subsp. equi is the etiologic agent of strangles, an infectious disease affecting the upper respiratory tract and head and neck lymph nodes of equines. Routine antimicrobial therapy includes penicillin (PEN) as antibiotic of first choice. Streptococci are usually susceptible to PEN and only a few antimicrobial studies had been performed. The aim of this work was to study the antimicrobial susceptibility profile of S. equi from Buenos Aires, Argentina. Ninety-two isolates were studied by the single disk method to PEN, cefotaxime, erythromycin (ERY), tetracycline, enrofloxacin (ENR), trimethoprim sulfamethoxazole (TMS), ciprofloxacin, clindamycin (CLI), streptomycin (STR) and florfenicol...
November 30, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29198093/-strenuous-and-prolonged-exercise-and-upper-respiratory-tract-infection-treatment-or-threat
#17
REVIEW
Danit Atias-Varon, Yuval Heled
Prolonged and strenuous exercise may lead to changes in the immune system function and to temporary suppression in defense against pathogens. These changes likely increase the risk of those engaging in prolonged and strenuous physical activity to develop upper respiratory tract infection and to reduce the level of performance. On the other hand, it appears that moderate physical activity reduces the risk of upper respiratory tract infection. Various populations, such as professional athletes and soldiers in combat units, who engage in daily strenuous exercise, may therefore be a high risk group...
November 2017: Harefuah
https://www.readbyqxmd.com/read/29189253/probiotics-in-preventing-acute-upper-respiratory-tract-infections
#18
JoAnn D Long, Andrea Morris
Editor's note: This is a summary of a nursing care-related systematic review from the Cochrane Library. For more information, see http://nursingcare.cochrane.org.
December 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/29187719/-small-animal-aspergillosis-and-cryptococcosis-in-japan
#19
Rui Kano
 Canine and feline upper respiratory tract (URT) infection due to Aspergillus spp. is considered an emerging disease, with the number of reported cases continuing to rise in Japan. Aspergillus fumigatus has been the most frequently reported etiologic agent of sino-orbital aspergillosis in dogs and cats; the other Aspergillus species, Aspergillus felis, Aspergillus fischeri, Aspergillus udagawae, Aspergillus viridinutans, and A. fumigatus, have also been implicated in feline cases. The minimum inhibitory concentrations (MICs) of antifungal drugs are elevated for these cryptic species compared with A...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/29187546/pathogenesis-humoral-immune-responses-and-transmission-between-co-housed-animals-in-a-ferret-model-of-human-rsv-infection
#20
Kok Fei Chan, Louise A Carolan, Julian Druce, Keith Chappell, Daniel Watterson, Paul Young, Daniil Korenkov, Kanta Subbarao, Ian G Barr, Karen L Laurie, Patrick C Reading
Small animal models have been used to obtain many insights regarding the pathogenesis and immune responses induced following infection with human respiratory syncytial virus (hRSV). Amongst those described to date, infections in cotton rats, mice, guinea pigs, chinchillas and Syrian hamsters with hRSV strains Long and/or A2 have been well characterised, although clinical isolates have also been examined. Ferrets are also susceptible to hRSV infection but the pathogenesis and immune responses elicited following infection have not been well characterised...
November 29, 2017: Journal of Virology
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