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https://www.readbyqxmd.com/read/28072826/rna-dependent-rna-polymerases-of-both-virulent-and-benign-rabbit-caliciviruses-induce-striking-rearrangement-of-golgi-membranes
#1
Nadya Urakova, Tanja Strive, Michael Frese
The extremely pathogenic Rabbit haemorrhagic disease virus (RHDV) and the completely benign Rabbit calicivirus (RCV) are closely related members of the genus Lagovirus (family Caliciviridae). The molecular mechanisms that determine the dramatic difference in virulence are unknown, but indirect evidence suggests that different properties of their RNA-dependent RNA polymerases (RdRps) may at least partially be responsible for the contrasting phenotypes. Here we report that the unusual ability of the RHDV RdRp to induce a striking rearrangement of the Golgi network is not specific to RHDV, but a common feature of virulent and benign rabbit caliciviruses alike...
2017: PloS One
https://www.readbyqxmd.com/read/28045956/recombinase-polymerase-amplification-assay-a-simple-fast-and-cost-effective-alternative-to-real-time-pcr-for-specific-detection-of-feline-herpesvirus-1
#2
Jianchang Wang, Libing Liu, Jinfeng Wang, Xiaoxia Sun, Wanzhe Yuan
Feline herpesvirus 1 (FHV-1), an enveloped dsDNA virus, is one of the major pathogens of feline upper respiratory tract disease (URTD) and ocular disease. Currently, polymerase chain reaction (PCR) remains the gold standard diagnostic tool for FHV-1 infection but is relatively expensive, requires well-equipped laboratories and is not suitable for field tests. Recombinase polymerase amplification (RPA), an isothermal gene amplification technology, has been explored for the molecular diagnosis of infectious diseases...
2017: PloS One
https://www.readbyqxmd.com/read/28040848/new-proof-of-concept-in-viral-inactivation-virucidal-efficacy-of-405%C3%A2-nm-light-against-feline-calicivirus-as-a-model-for-norovirus-decontamination
#3
Rachael M Tomb, Michelle Maclean, John E Coia, Elizabeth Graham, Michael McDonald, Chintamani D Atreya, Scott J MacGregor, John G Anderson
The requirement for novel decontamination technologies for use in hospitals is ever present. One such system uses 405 nm visible light to inactivate microorganisms via ROS-generated oxidative damage. Although effective for bacterial and fungal inactivation, little is known about the virucidal effects of 405 nm light. Norovirus (NoV) gastroenteritis outbreaks often occur in the clinical setting, and this study was designed to investigate potential inactivation effects of 405 nm light on the NoV surrogate, feline calicivirus (FCV)...
December 31, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/28040178/blueberry-proanthocyanidins-against-human-norovirus-surrogates-in-model-foods-and-under-simulated-gastric-conditions
#4
Snehal Joshi, Amy B Howell, Doris H D'Souza
Blueberry proanthocyanidins (B-PAC) are known to decrease titers of human norovirus surrogates in vitro. The application of B-PAC as therapeutic or preventive options against foodborne viral illness needs to be determined using model foods and simulated gastric conditions in vitro. The objective of this study was to evaluate the antiviral effect of B-PAC in model foods (apple juice (AJ) and 2% reduced fat milk) and simulated gastrointestinal fluids against cultivable human norovirus surrogates (feline calicivirus; FCV-F9 and murine norovirus; MNV-1) over 24 h at 37 °C...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/27909112/norovirus-and-other-human-calicivirus-infections
#5
EDITORIAL
Jacob J Rosenberg
No abstract text is available yet for this article.
December 2016: Pediatrics in Review
https://www.readbyqxmd.com/read/27902397/vesivirus-2117-capsids-more-closely-resemble-sapovirus-and-lagovirus-particles-than-other-known-vesivirus-structures
#6
Michaela Conley, Edward Emmott, Richard Orton, David Taylor, Daniel Carneiro, Kazuyoshi Murata, Ian Goodfellow, Grant Hansman, David Bhella
Vesivirus 2117 is an adventitious agent that in 2009, was identified as a contaminant of CHO cells propagated in bioreactors at a pharmaceutical manufacturing plant belonging to Genzyme. The consequent interruption in supply of Fabrazyme and Cerezyme (drugs used to treat Fabry and Gaucher disease respectively), caused significant economic losses. Vesivirus 2117 is a member of the Caliciviridae; a family of small icosahedral viruses encoding a positive sense RNA genome. We have used cryo-electron microscopy and three dimensional image reconstruction to calculate a structure of vesivirus 2117 virus like particles as well as feline calicivirus and a chimeric sapovirus...
November 14, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902382/genetic-diversity-and-phenotypic-associations-of-feline-caliciviruses-from-cats-in-switzerland
#7
Andrea M Spiri, Julien Thézé, Marina L Meli, Valentino Cattori, Alice Berger, Adolf Steinrigl, Oliver G Pybus, Regina Hofmann-Lehmann, Barbara Willi
Feline calicivirus (FCV) is a common viral pathogen in domestic cats worldwide. The variable regions of the capsid (VP1) gene of FCV have one of the highest recorded rates of molecular evolution. Understanding the genetic diversity and phylogeny of FCV is a prerequisite to exploring the epidemiology and pathogenesis of this virus and to the development of efficacious vaccine strategies. In this study, we undertook a nationwide molecular characterization of FCV using for the first time nearly complete capsid (VP1) gene sequences...
December 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27886032/prevalence-and-factors-associated-with-different-pathogens-of-acute-diarrhea-in-adults-in-beijing-china
#8
Lei Jia, Changying Lin, Zhiyong Gao, Mei Qu, Junyong Yang, Jingyi Sun, He Chen, Quanyi Wang
INTRODUCTION: Only a small proportion of patients with diarrhea are diagnosed with laboratory tests in China, and most are diagnosed based on clinical symptoms. Therefore, understanding the prevalence of different diarrheal pathogens and their specific symptoms is important. METHODOLOGY: Data from a prospective study in Beijing of acute diarrhea and the related pathogens were used to study the association between different pathogen groups and the infected patients' characteristics...
November 24, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27881647/activation-of-cox-2-pge2-promotes-sapovirus-replication-via-the-inhibition-of-nitric-oxide-production
#9
Mia Madel Alfajaro, Jong-Soon Choi, Deok-Song Kim, Ja-Young Seo, Ji-Yun Kim, Jun-Gyu Park, Mahmoud Soliman, Yeong-Bin Baek, Eun-Hyo Cho, Joseph Kwon, Hyung-Jun Kwon, Su-Jin Park, Woo Song Lee, Mun-Il Kang, Myra Hosmillo, Ian Goodfellow, Kyoung-Oh Cho
: Enteric caliciviruses in the genera Norovirus and Sapovirus are important pathogens that cause severe acute gastroenteritis in both humans and animals. Cyclooxygenases (COXs) and their final product prostaglandin E2 (PGE2) are known to play important roles in the modulation of both the host response to the infection and replicative cycle of several viruses. However, the precise mechanism(s) by which the COXs/PGE2 pathway regulates sapoviruses replication remains largely unknown. In this study, the infection of porcine sapovirus (PSaV) Cowden strain, the only cultivable virus within the genus Sapovirus, markedly increased COX-2 mRNA and protein levels at 24 and 36 hours post-infection (hpi) with only a transient increase of COX-1 levels seen at 24 hpi...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27865960/identification-of-inonotus-obliquus-polysaccharide-with-broad-spectrum-antiviral-activity-against-multi-feline-viruses
#10
Jin Tian, Xiaoliang Hu, Dafei Liu, Hongxia Wu, Liandong Qu
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of feline calicivirus (FCV), we demonstrated that IOP treatment was capable of exhibiting anti-FCV strain F9 activity in cell-based assays and also showed low cytotoxicity. Investigation of the mechanism of action of the compound revealed that IOP treatment induces its inhibitory actions directly on virus particles through blocking viral binding/absorpting...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27807684/inhibition-of-murine-norovirus-and-feline-calicivirus-by-edible-herbal-extracts
#11
Dong Joo Seo, Changsun Choi
Human noroviruses (HuNoVs) cause foodborne and waterborne viral gastroenteritis worldwide. Because HuNoV culture systems have not been developed thus far, no available medicines or vaccines preventing infection with HuNoVs exist. Some herbal extracts were considered as phytomedicines because of their bioactive components. In this study, the inhibitory effects of 29 edible herbal extracts against the norovirus surrogates murine norovirus (MNV) and feline calicivirus (FCV) were examined. FCV was significantly inhibited to 86...
November 2, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27783334/inactivation-of-viruses-and-bacteriophages-as-models-for-swine-hepatitis-e-virus-in-food-matrices
#12
Eva Emmoth, Jordi Rovira, Andreja Rajkovic, Elena Corcuera, Diego Wilches Pérez, Irene Dergel, Jakob R Ottoson, Frederik Widén
Hepatitis E virus has been recognised as a food-borne virus hazard in pork products, due to its zoonotic properties. This risk can be reduced by adequate treatment of the food to inactivate food-borne viruses. We used a spectrum of viruses and bacteriophages to evaluate the effect of three food treatments: high pressure processing (HPP), lactic acid (LA) and intense light pulse (ILP) treatments. On swine liver at 400 MPa for 10 min, HPP gave log10 reductions of ≥4.2, ≥5.0 and 3.4 for feline calicivirus (FCV) 2280, FCV wildtype (wt) and murine norovirus 1 (MNV 1), respectively...
October 25, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27765132/-surveillance-for-viral-diarrhea-in-sentinel-hospitals-in-henan-province-2013-2015
#13
J Y Zhao, X J Shen, B F Zhang, Z Q Wang, S L Xia, X Y Huang, B L Xu
Objective: To investigate the infection status of human rotavirus, calicivirus, astrovirus and enteric adenovirus in children aged <5 years in disease surveillance areas in Henan province from 2013 to 2015. Methods: A total of 880 stool samples were collected from four sentinel hospitals and group A rotavirus was detected by ELISA and group A rotavirus G/P genotyping was performed with nested multiplex RT-PCR, while rotavirus (group B, C), calicivirus and astrovirus were detected by two-step multiplex RT-PCR and adenovirus were detected by PCR...
October 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27763827/serosurvey-for-selected-viral-pathogens-among-sympatric-species-of-the-african-large-predator-guild-in-northern-botswana
#14
Anne-Lise Chaber, Gabriele Cozzi, Femke Broekhuis, Robyn Hartley, John W McNutt
The recent increase in the creation of transboundary protected areas and wildlife corridors between them lends importance to information on pathogen prevalence and transmission among wildlife species that will become connected. One such initiative is the Kavango Zambezi Transfrontier Conservation Area of which Botswana's Okavango Delta constitutes a major contribution for wildlife and ecosystems. Between 2008 and 2011, we collected serum samples from 14 lions ( Panthera leo ), four leopards ( Panthera pardus ), 19 spotted hyenas ( Crocuta crocuta ), and six cheetahs ( Acinonyx jubatus ) in the Okavango...
January 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/27756911/antiviral-effect-of-theaflavins-against-caliciviruses
#15
Mai Ohba, Tomoichiro Oka, Takayuki Ando, Saori Arahata, Asaka Ikegaya, Hirotaka Takagi, Naohisa Ogo, Chelsea Zhu, Kazuhiro Owada, Fumihiko Kawamori, Qiuhong Wang, Linda J Saif, Akira Asai
Caliciviruses are contagious pathogens of humans and various animals. They are the most common cause of viral gastroenteritis in humans, and can cause lethal diseases in domestic animals such as cats, rabbits and immunocompromised mice. In this study, we conducted cytopathic effect-based screening of 2080 selected compounds from our in-house library to find antiviral compounds against three culturable caliciviruses: feline calicivirus, murine norovirus (MNV) and porcine sapovirus (PoSaV). We identified active six compounds, of which two compounds, both related to theaflavins, showed broad antiviral activities against all three caliciviruses; three compounds (abamectin, a mixture of avermectin B1a and B1b; avermectin B1a; and (-)-epigallocatechin gallate hydrate) were effective against PoSaV only; and a heterocyclic carboxamide derivative (BFTC) specifically inhibited MNV infectivity in cell cultures...
October 19, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27751221/-epidemiological-and-clinical-features-of-calicivirus-associated-diarrhea-in-hospitalized-children-in-chengdu-china-from-2012-to-2014
#16
Li-Hong Shang, Li-Jing Xiong, Li-Rong Liu, Xiao-Zhi Deng, Xiao-Li Xie
OBJECTIVE: To investigate the epidemiological and clinical features of calicivirus-associated diarrhea in hospitalized children in Chengdu, China in recent years. METHODS: The clinical data of 267 children with calicivirus-associated diarrhea aged <5 years who were hospitalized in Chengdu Women and Children's Central Hospital (the only sentinel hospital for sample collection of pediatric viral diarrhea in Chengdu, Sichuan) between January 2012 and December 2014 were retrospectively studied...
October 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27736043/feasibility-of-viral-dust-infection-via-air-movement-and-dispersion-of-dried-viral-particles-from-the-floor
#17
Mori Kohji, Ohnuki Aya, Kanou Fumio, Akiba Tetsuya, Hayashi Yukinao, Shirasawa Hiroshi, Sadamasu Kenji
The contributions of splash from vomiting and the dispersion of dried-up virus from a contaminated floor surface to community gastroenteritis outbreaks caused by Norovirus (NoV) were evaluated, using Feline calicivirus (FCV) as an NoV surrogate. There was no difference in the size distribution of FCV-containing particles around 0.75 µm) collected from a virus-sprayed chamber 1h and 12 h after nebulization. FCV clearly dispersed after hitting a floor surface contaminated with dried virus. These results suggest that NoV can likely form airborne droplet nuclei, and dust may be the main route of infection transmission...
October 13, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27706762/genomic-characterization-and-phylogenetic-analysis-of-chinese-sacbrood-virus-isolated-from-loess-plateau-china
#18
H Yu, T X Liu, D Wang
The complete genomic RNA of the Chinese sacbrood virus (CSBV) strain, which infects the honeybees in the Loess plateau, was sequenced and analyzed. The CSBV-SX strain contains 8705 nucleotides, which includes a single large open reading frame (99-8681 nucleotides) encoding 2860 amino acids. A novel efficient identification method was used to investigate the samples infected by CSBV. The putative amino acid sequence alignment analysis showed that, except for some normal well characterized domains such as RNA helicase, RNA protease, and RNA-dependent RNA polymerase domains, a calicivirus coat protein domain was identified at amino acids 493-564...
September 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27669009/surveillance-for-viral-and-parasitic-pathogens-in-a-vulnerable-african-lion-panthera-leo-population-in-the-northern-tuli-game-reserve-botswana
#19
Kimberly R McDermid, Andrei Snyman, Frederick J Verreynne, John P Carroll, Banie L Penzhorn, Michael J Yabsley
African lion ( Panthera leo ) numbers are decreasing rapidly and populations are becoming smaller and more fragmented. Infectious diseases are one of numerous issues threatening free-ranging lion populations, and low-density populations are particularly at risk. We collected data on the prevalence and diversity of viral and parasitic pathogens in a small lion population in eastern Botswana. During 2012 and 2014, blood samples were collected from 59% (n=13) of the adult-subadult lions in the Northern Tuli Game Reserve in eastern Botswana...
January 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/27663519/emergence-of-human-caliciviruses-among-diarrhea-cases-in-southwest-china
#20
Shun-Xian Zhang, Li Li, Jian-Wen Yin, Miao Jin, Xiang-Yu Kong, Li-Li Pang, Yong-Kang Zhou, Li-Guang Tian, Jia-Xu Chen, Xiao-Nong Zhou
BACKGROUND: Acute diarrhea is one of the most serious problems in global public health that causes considerable morbidity and mortality worldwide. Human caliciviruses (HuCV) including norovirus (NoV, genogroup GI and GII) and sapovirus (SaV), is a leading cause of acute sporadic diarrhea in individuals across all age groups. However, few studies had been conducted clarifying the characteristics of HuCV in diarrhea cases across all age groups in China. Our study was aimed at assessing the HuCV-related diarrhea burden and NoV genotypes distribution in southwest China...
2016: BMC Infectious Diseases
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