Thomas Agius, Raffaella Emsley, Arnaud Lyon, Michael R MacArthur, Kevin Kiesworo, Anna Faivre, Louis Stavart, Martine Lambelet, David Legouis, Sophie de Seigneux, Déla Golshayan, Francois Lazeyras, Heidi Yeh, James F Markmann, Korkut Uygun, Alejandro Ocampo, Sarah J Mitchell, Florent Allagnat, Sébastien Déglise, Alban Longchamp
Dietary restriction promotes resistance to surgical stress in multiple organisms. Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks (carbohydrate loading) prior to surgery, part of a multimodal perioperative care pathway designed to enhance surgical recovery. Despite widespread clinical use, preclinical and mechanistic studies on carbohydrate loading in surgical contexts are lacking. Here we demonstrate in ad libitum-fed mice that liquid carbohydrate loading for one week drives reductions in solid food intake, while nearly doubling total caloric intake...
February 5, 2024: Nature Communications