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https://www.readbyqxmd.com/read/28440917/atf3-inhibits-the-inflammation-induced-by-mycoplasma-pneumonia-in-vitro-and-in-vivo
#1
Jing Wang, Wei Cheng, Zhen Wang, Lihong Xin, Wen Zhang
OBJECTIVES: Activating transcription factor-3 (ATF3) is a key regulator of inflammatory responses. We aimed to investigate the effects and mechanisms of ATF3 on the inflammatory cytokines are induced by Mycoplasma pneumonia (MP). STUDY DESIGN: RAW264.7 and mouse peritoneal macrophages were exposed to various time with or without MP infection (3, 6, 12, 24, and 48 h), and detect the expression of ATF3. Adenovirus-expression of ATF3 (Ad/ATF3) or Ad/βgal was transfected into cells which were exposed to MP for 48 h, RT-PCR and ELISA was used to evaluate the expression and secretion of TNF-α, IL-1β, IL-6, and IL-18...
April 25, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28414328/marginal-zone-b-cells-control-the-response-of-follicular-helper-t-cells-to-a-high-cholesterol-diet
#2
Meritxell Nus, Andrew P Sage, Yuning Lu, Leanne Masters, Brian Y H Lam, Stephen Newland, Sandra Weller, Dimitrios Tsiantoulas, Juliette Raffort, Damiënne Marcus, Alison Finigan, Lauren Kitt, Nichola Figg, Reinhold Schirmbeck, Manfred Kneilling, Giles S H Yeo, Christoph J Binder, José Luis de la Pompa, Ziad Mallat
Splenic marginal zone B (MZB) cells, positioned at the interface between circulating blood and lymphoid tissue, detect and respond to blood-borne antigens. Here we show that MZB cells in mice activate a homeostatic program in response to a high-cholesterol diet (HCD) and regulate both the differentiation and accumulation of T follicular helper (TFH) cells. Feeding mice an HCD resulted in upregulated MZB cell surface expression of the immunoregulatory ligand PDL1 in an ATF3-dependent manner and increased the interaction between MZB cells and pre-TFH cells, leading to PDL1-mediated suppression of TFH cell motility, alteration of TFH cell differentiation, reduced TFH abundance and suppression of the proatherogenic TFH response...
April 17, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28414095/crosstalk-control-and-limits-of-physiological-c-jun-n-terminal-kinase-activity-for-cell-viability-and-neurite-stability-in-differentiated-pc12-cells
#3
Vicki Waetzig, Milana Belzer, Wiebke Haeusgen, Ruwen Boehm, Ingolf Cascorbi, Thomas Herdegen
The c-Jun N-terminal kinases (JNKs) are important mediators of cell viability and structural integrity in postmitotic neurons, which is required for maintaining synaptic connections and neural plasticity. In the present study, we chose differentiated PC12 cells as a well-characterised neuronal model system to selectively examine the regulation of basal JNK activity by extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt. We detected a complex interaction between the kinases to prevent cell death and neurite loss...
April 14, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28402947/overexpression-of-the-transcription-factor-atf3-with-a-regulatory-molecular-signature-associates-with-the-pathogenic-development-of-colorectal-cancer
#4
Feng Yan, Le Ying, Xiaofang Li, Bin Qiao, Qiaohong Meng, Liang Yu, Xiangliang Yuan, Shu-Ting Ren, David W Chan, Liyun Shi, Peihua Ni, Xuefeng Wang, Dakang Xu, Yiqun Hu
The identification of novel biomarkers of cancer is important for improved diagnosis and prognosis. With an abundant amount of resources in the publicly available database, such as the Cancer Genome Atlas (TCGA) database, an integrative strategy is used to systematically characterize the aberrant patterns of colorectal cancer (CRC) based on RNA-Seq, chromatin immunoprecipitation sequencing (ChIP-Seq), tissue microarray (TMA), gene profiling and molecular signatures. The expression of the transcription factor ATF3 was elevated in human CRC specimens in a TMA by immunochemistry analysis compared to the adjacent normal tissues...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28401021/integrated-mrna-and-lncrna-expression-profiling-for-exploring-metastatic-biomarkers-of-human-intrahepatic-cholangiocarcinoma
#5
Lisheng Lv, Miaoyan Wei, Peiyi Lin, Zhisheng Chen, Peng Gong, Zhiwei Quan, Zhaohui Tang
Long noncoding RNAs (lncRNAs) is crucial for various human cancers, but the function and mechanism of lncRNAs is largely unknown in human intrahepatic cholangiocarcinoma (ICC), the second most common liver cancer. In this study, we performed transcriptomic profiling of ICC and normal tissues, and found 2148 lncRNAs and 474 mRNAs were significantly upregulated, whereas 568 lncRNAs and 409 mRNAs were downregulated in ICC tissues. Enrichment analysis suggests these differentially expressed genes mainly focus on response to stimulus, development, and cell proliferation...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28392644/transcription-factors-regulating-inflammatory-cytokine-production-are-differentially-expressed-in-peripheral-blood-mononuclear-cells-of-beh%C3%A3-et-disease-depending-on-disease-activity
#6
Min-Yeong Woo, Su Jin Yun, Mi Jin Lee, Kyongmin Kim, Eun-So Lee, Sun Park
BACKGROUND: Behçet disease (BD) is a relapsing inflammatory disease with increased production of inflammatory cytokines in peripheral blood mononuclear cells (PBMCs); however, the underlying molecular mechanisms are not well known. OBJECTIVE: To analyze whether the differential expression of transcription factors is involved in the increased tumor necrosis factor (TNF)-α and interleukin (IL)-6 production by PBMCs of BD patients compared to healthy controls (HCs)...
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28380462/metformin-inhibits-proliferation-and-growth-hormone-secretion-of-gh3-pituitary-adenoma-cells
#7
Jiayin An, Xiangdong Pei, Zhenle Zang, Zheng Zhou, Jintao Hu, Xin Zheng, Yin Zhang, Jiaojiang He, Lian Duan, Rufei Shen, Weihua Zhang, Feng Zhu, Song Li, Hui Yang
Metformin is an anti-hyperglycemic agent used to treat diabetes, and recent evidence suggests it has antitumor efficacy. Because growth hormone-secreting pituitary adenoma (GH-PA) patients have a high incidence of diabetes frequently treated with metformin, we assessed the antitumor effect of metformin on GH-PA. We found that metformin effectively inhibited proliferation and induced apoptosis in the GH-PA cell line GH3. We detected a decrease in mitochondrial membrane potential (MMP), an increase in expression of pro-apoptotic proteins, and a decrease in expression of an anti-apoptotic protein in metformin-treated GH3 cells, which suggests involvement of the mitochondrial-mediated apoptosis pathway...
March 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28365312/activating-transcription-factor-3-is-a-target-molecule-linking-hepatic-steatosis-to-impaired-glucose-homeostasis
#8
Ji Yeon Kim, Keon Jae Park, Joo-Yeon Hwang, Gyu Hee Kim, DaeYeon Lee, Yoo Jeong Lee, Eun Hyun Song, Min-Gyu Yoo, Bong-Jo Kim, Young Ho Suh, Gu Seob Roh, Bin Gao, Won Kim, Won-Ho Kim
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) contributes to impaired glucose tolerance, leading to type 2 diabetes (T2D); however, the precise mechanisms and target molecules that are involved remain unclear. Activating transcription factor 3 (ATF3) is associated with β-cell dysfunction that is induced by severe stress signals in T2D. We aimed to explore the exact functional role of ATF3 as a mechanistic link between hepatic steatosis and T2D development. METHODS: Zucker diabetic fatty (ZDF) rats were utilized for animal experiments...
March 30, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28340361/hdl-inhibits-saturated-fatty-acid-mediated-augmentation-of-innate-immune-responses-in-endothelial-cells-by-a-novel-pathway
#9
Wei-Yang Zhang, Daniel A Franco, Eric Schwartz, Karen D'Souza, Sheetal Karnick, Peter D Reaven
BACKGROUND AND AIMS: Peripheral insulin resistance is associated with several metabolic abnormalities, including elevated serum fatty acids that contribute to vascular injury and atherogenesis. Our goals were to examine whether saturated fatty acids can modify innate immune responses to subclinical concentrations of lipopolysaccharide (LPS) in endothelial cells, and to explore the underlying pathway and determine whether it is modified by high density lipoprotein (HDL) and other factors commonly altered in insulin resistance...
April 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28324645/three-dimensional-analysis-of-somatic-mitochondrial-dynamics-in-fission-deficient-injured-motor-neurons-using-fib-sem
#10
Hiromi Tamada, Sumiko Kiryu-Seo, Hiroki Hosokawa, Keisuke Ohta, Naotada Ishihara, Masatoshi Nomura, Katsuyoshi Mihara, Kei-Ichiro Nakamura, Hiroshi Kiyama
Mitochondria undergo morphological changes through fusion and fission for their quality control, which are vital for neuronal function. In this study, we examined three-dimensional morphologies of mitochondria in motor neurons under normal, nerve injured, and nerve injured plus fission-impaired conditions using the focused ion beam/scanning electron microscopy (FIB/SEM), because the FIB/SEM technology is a powerful tool to demonstrate both 3D images of whole organelle and the intra-organellar structure simultaneously...
March 21, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28281638/mir-34a-5p-promotes-multi-chemoresistance-of-osteosarcoma-through-down-regulation-of-the-dll1-gene
#11
Youguang Pu, Fangfang Zhao, Haiyan Wang, Shanbao Cai
MiR-34a-5p has been implicated in the tumorigenesis and progression of several types of cancer. However, the role of miR-34a-5p in osteosarcoma (OS) remains largely unknown. This study was performed in two multi-chemosensitive (G-292 and MG63.2) and two resistant (SJSA-1 and MNNG/HOS) OS cell lines. MiR-34a-5p promotes OS multi-chemoresistance via its repression of the Delta-like ligand 1 (DLL1) gene, the ligand of the Notch pathway, and thus negatively correlates with OS chemoresistance. The siRNA-mediated repression of the DLL1 gene suppressed cell apoptosis and de-sensitized G-292 and MG63...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275095/bap1-inhibits-the-er-stress-gene-regulatory-network-and-modulates-metabolic-stress-response
#12
Fangyan Dai, Hyemin Lee, Yilei Zhang, Li Zhuang, Hui Yao, Yuanxin Xi, Zhen-Dong Xiao, M James You, Wei Li, Xiaoping Su, Boyi Gan
The endoplasmic reticulum (ER) is classically linked to metabolic homeostasis via the activation of unfolded protein response (UPR), which is instructed by multiple transcriptional regulatory cascades. BRCA1 associated protein 1 (BAP1) is a tumor suppressor with de-ubiquitinating enzyme activity and has been implicated in chromatin regulation of gene expression. Here we show that BAP1 inhibits cell death induced by unresolved metabolic stress. This prosurvival role of BAP1 depends on its de-ubiquitinating activity and correlates with its ability to dampen the metabolic stress-induced UPR transcriptional network...
March 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28272390/atf3-acts-as-a-rheostat-to-control-jnk-signalling-during-intestinal-regeneration
#13
Jun Zhou, Bruce A Edgar, Michael Boutros
Epithelial barrier function is maintained by coordination of cell proliferation and cell loss, whereas barrier dysfunction can lead to disease and organismal death. JNK signalling is a conserved stress signalling pathway activated by bacterial infection and tissue damage, often leading to apoptotic cell death and compensatory cell proliferation. Here we show that the stress inducible transcription factor ATF3 restricts JNK activity in the Drosophila midgut. ATF3 regulates JNK-dependent apoptosis and regeneration through the transcriptional regulation of the JNK antagonist, Raw...
March 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28253359/csb-ablation-induced-apoptosis-is-mediated-by-increased-endoplasmic-reticulum-stress-response
#14
Manuela Caputo, Alessio Balzerano, Ivan Arisi, Mara D'Onofrio, Rossella Brandi, Silvia Bongiorni, Stefano Brancorsini, Mattia Frontini, Luca Proietti-De-Santis
The DNA repair protein Cockayne syndrome group B (CSB) has been recently identified as a promising anticancer target. Suppression, by antisense technology, of this protein causes devastating effects on tumor cells viability, through a massive induction of apoptosis, while being non-toxic to non-transformed cells. To gain insights into the mechanisms underlying the pro-apoptotic effects observed after CSB ablation, global gene expression patterns were determined, to identify genes that were significantly differentially regulated as a function of CSB expression...
2017: PloS One
https://www.readbyqxmd.com/read/28250971/atf3-reduces-migration-capacity-by-regulation-of-matrix-metalloproteinases-via-nf%C3%AE%C2%BAb-and-stat3-inhibition-in-glioblastoma
#15
Jessica Guenzle, Louisa J Wolf, Nicklas W C Garrelfs, Jonathan M Goeldner, Nadja Osterberg, Cora R Schindler, Joseph E Saavedra, Astrid Weyerbrock
Glioblastoma is associated with poor survival and a high recurrence rate in patients due to inevitable uncontrolled infiltrative tumor growth. The elucidation of the molecular mechanisms may offer opportunities to prevent relapses. In this study we investigated the role of the activating transcription factor 3 (ATF3) in migration of GBM cells in vitro. RNA microarray revealed that gene expression of ATF3 is induced by a variety of chemotherapeutics and experimental agents such as the nitric oxide donor JS-K (O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate)...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28250112/editorial-binge-drinking-lessons-from-atf3-and-hdac1-collaboration
#16
EDITORIAL
Banishree Saha
No abstract text is available yet for this article.
March 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28249877/cardiac-fibroblast-specific-activating-transcription-factor-3-protects-against-heart-failure-by-suppressing-map2k3-p38-signaling
#17
Yulin Li, Zhenya Li, Congcong Zhang, Ping Li, Yina Wu, Chunxiao Wang, Wayne Bond Lau, Xin-Liang Ma, Jie Du
Background -Hypertensive ventricular remodeling is a common cause of heart failure. However, the molecular mechanisms regulating ventricular remodeling remain poorly understood. Methods -We used a discovery-driven/nonbiased approach to indentify increased ATF3 expression in hypertensive heart. We employed loss/gain of function approaches to understand the role of ATF3 in heart failure. We also examine the mechanisms through transcriptome, CHIP-seq analysis and in vivo and vitro experiments. Results -ATF3 expression increased in murine hypertensive heart and human hypertrophic heart...
March 1, 2017: Circulation
https://www.readbyqxmd.com/read/28239957/activating-transcription-factor-3-promotes-malignance-of-lung-cancer-cells-in-vitro
#18
Xuebing Li, Xuexia Zhou, Yongwen Li, Lingling Zu, Hongli Pan, Boning Liu, Wang Shen, Yaguang Fan, Qinghua Zhou
BACKGROUND: Lung cancer remains the most common cause of cancer-related death, with high rates of recurrence and poor outcomes. An abnormally high expression of activating transcription factor 3 (ATF3) in various cancers suggests an oncogenic role; however, its function in lung cancer is largely unknown. METHODS: Sixty-four pairs of lung cancer tissues were collected for ATF3 expression analysis by quantitative real-time PCR, immunoblotting, and immunohistochemistry staining...
February 27, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28210955/the-effects-of-igf-1-on-tnf-%C3%AE-treated-drg-neurons-by-modulating-atf3-and-gap-43-expression-via-pi3k-akt-s6k-signaling-pathway
#19
Lei Zhang, Yaping Yue, Meishuo Ouyang, Huaxiang Liu, Zhenzhong Li
Upregulation of the pro-inflammatory cytokine tumor necrosis factor α (TNF-α) is involved in the development and progression of numerous neurological disorders. Recent reports have challenged the concept that TNF-α exhibits only deleterious effects of pro-inflammatory destruction, and have raised the awareness that it may play a beneficial role in neuronal growth and function in particular conditions, which prompts us to further investigate the role of this cytokine. Insulin-like growth factor-1 (IGF-1) is a cytokine possessing powerful neuroprotective effects in promoting neuronal survival, neuronal differentiation, neurite elongation, and neurite regeneration...
February 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28205069/transcriptomic-analysis-of-thp-1-macrophages-exposed-to-lipoprotein-hydrolysis-products-generated-by-lipoprotein-lipase
#20
Narmadaa Thyagarajan, Jenika D Marshall, Arthur T Pickett, Clemens Schumacher, Yanbo Yang, Sherri L Christian, Robert J Brown
Macrophage lipoprotein lipase (LPL) induces lipid accumulation and promotes atherosclerosis. However, the effects of lipoprotein hydrolysis products generated by LPL on macrophage-derived foam cell formation are not clearly understood. Thus, we analyzed the transcriptomic response to hydrolysis products via microarray analyses on RNA isolated from human THP-1 macrophages incubated with total lipoprotein hydrolysis products generated by LPL. The expression of 183 transcripts was significantly upregulated and 133 transcripts were significantly downregulated...
March 2017: Lipids
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