keyword
https://read.qxmd.com/read/38203800/effect-of-nutraceutical-factors-on-hepatic-intermediary-metabolism-in-wistar-rats-with-induced-tendinopathy
#21
JOURNAL ARTICLE
Marta Ramos-Barbero, Eva E Rufino-Palomares, Sergio Serrano-Carmona, Manuel Hernández-Yera, Leticia García-Salguero, José Antonio Lupiáñez, Amalia Pérez-Jiménez
Tendinopathy (TP) is a complex clinical syndrome characterized by local inflammation, pain in the affected area, and loss of performance, preceded by tendon injury. The disease develops in three phases: Inflammatory phase, proliferative phase, and remodeling phase. There are currently no proven treatments for early reversal of this type of injury. However, the metabolic pathways of the transition metabolism, which are necessary for the proper functioning of the organism, are known. These metabolic pathways can be modified by a number of external factors, such as nutritional supplements...
January 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38198469/the-dose-response-effects-of-flurbiprofen-indomethacin-ibuprofen-and-naproxen-on-primary-skeletal-muscle-cells
#22
JOURNAL ARTICLE
Brandon M Roberts, Alyssa V Geddis, Ronald W Matheny
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, flurbiprofen, naproxen sodium, and indomethacin are commonly employed for their pain-relieving and inflammation-reducing qualities. NSAIDs work by blocking COX-1 and/or COX-2, enzymes which play roles in inflammation, fever, and pain. The main difference among NSAIDs lies in their affinity to these enzymes, which in turn, influences prostaglandin secretion, and skeletal muscle growth and regeneration. The current study investigated the effects of NSAIDs on human skeletal muscle cells, focusing on myoblast proliferation, differentiation, and muscle protein synthesis signaling...
December 2024: Journal of the International Society of Sports Nutrition
https://read.qxmd.com/read/38193288/diagnostic-and-therapeutic-value-of-intracellular-biomarker-testing-in-chronic-pain
#23
JOURNAL ARTICLE
Alice L Ye, Emily W Sudek, Daniela Magdaleno, Carlos J Roldan
Aim: Micronutrient and metabolic compound supplementation as a method of treating chronic pain is not well understood. Case: A 58 year-old woman presented with refractory painful neuropathy. She did not respond to conservative treatment and was seeking spinal cord stimulator implantation. She underwent a biomarker panel that revealed low intracellular levels of multiple compounds. As she supplemented her deficiencies, her symptoms fully resolved, and the implant was no longer indicated. Discussion: Micronutrient and metabolic compound testing could potentially expand non-invasive treatment options for patients with refractory chronic pain...
January 9, 2024: Pain Management
https://read.qxmd.com/read/38190073/nurse-supervised-at-institutes-versus-nurse-counseling-home-based-resistance-exercise-training-for-acute-pancreatitis
#24
JOURNAL ARTICLE
Jing Huang, Hui Zhang
BACKGROUND: The physical and mental quality of life of patients with acute pancreatitis is poor. Professional nurses have the necessary knowledge, art, and skills to aid in resistance exercise training. AIMS: To evaluate the effectiveness of 6 months of nurse-supervised resistance exercise training plus nutritional supplements and 6 months of nurse counseling home-based resistance exercise training plus nutritional supplements for patients with pancreatitis...
January 8, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38180010/open-observational-single-arm-multicenter-study-assessing-the-effectiveness-of-a-dietary-supplement-containing-hydrolyzed-collagen-chondroitin-sulfate-and-glucosamine-for-osteoarthritis-pain-reduction
#25
JOURNAL ARTICLE
Jordi Puigdellívol Grifell, Carme Comellas Berenguer, Gilbert Steinbacher, Tomislav Kranjcec, Pedro Álvarez Díaz, Antoni López Pujol, Asunción Acosta Pereira, Maximiliano Sánchez Martos, José Reyes Fernández Velázquez, Miguel Ángel Esparza Pagán, Víctor Lainez Romo, Luis Payán Martín, Jordi Giménez Gonzalo, Christian Carreras Vidal, José David Sulbarán, Jaume Oliveras Riera
Osteoarthritis (OA) is an age-related degenerative joint disease with a great impact on patients' well-being and quality of life. This is an observational, open, single-arm multicenter study aimed to evaluate the effectiveness of a nutritional supplement in patients with knee and/or hip OA. A total of 186 patients were recruited from Spanish centers and received a supplement containing hydrolyzed collagen (3000 mg), chondroitin sulfate (800 mg), glucosamine sulfate (700 mg), turmeric extract (250 mg) and devil's claw (150 mg), once daily during 6 months...
January 5, 2024: Journal of Dietary Supplements
https://read.qxmd.com/read/38168330/disease-progression-and-clinical-outcomes-in-latent-osteoarthritis-phenotypes-data-from-the-osteoarthritis-initiative
#26
Zeyu Huang, Mary A Bucklin, Weihua Guo, John T Martin
The prevalence of knee osteoarthritis (OA) is widespread and the heterogeneous patient factors and clinical symptoms in OA patients impede developing personalized treatments for OA patients. In this study, we used unsupervised and supervised machine learning to organize the heterogeneity in knee OA patients and predict disease progression in individuals from the Osteoarthritis Initiative (OAI) dataset. We identified four distinct knee OA phenotypes using unsupervised learning that were defined by nutrition, disability, stiffness, and pain (knee and back) and were strongly related to disease fate...
December 15, 2023: medRxiv
https://read.qxmd.com/read/38087858/food-insecurity-is-associated-with-chronic-pain-and-high-impact-chronic-pain-in-the-united-states
#27
JOURNAL ARTICLE
Javier A Tamargo, Larissa J Strath, Shama D Karanth, Antoinette L Spector, Kimberly T Sibille, Stephen Anton, Yenisel Cruz-Almeida
OBJECTIVE: This study evaluated whether food insecurity (U.S. Adult Food Security Survey) was associated with chronic pain (≥3 months) and high-impact chronic pain (i.e., pain that limits work and life) among United States (U.S.) adults. DESIGN: Cross-sectional analysis. SETTING: Nationally representative sample of non-institutionalized adults in the United States. PARTICIPANTS: 79,686 adults from the National Health Interview Survey (2019-2021)...
December 13, 2023: Public Health Nutrition
https://read.qxmd.com/read/38082237/the-effects-of-curcumin-piperine-supplementation-on-inflammatory-oxidative-stress-and-metabolic-indices-in-patients-with-ischemic-stroke-in-the-rehabilitation-phase-a-randomized-controlled-trial
#28
RANDOMIZED CONTROLLED TRIAL
Kosar Boshagh, Fariborz Khorvash, Amirhossein Sahebkar, Muhammed Majeed, Nimah Bahreini, Gholamreza Askari, Mohammad Bagherniya
BACKGROUND: Stroke is a leading cause of death worldwide, which is associated with a heavy economic and social burden. The purpose of this study was to investigate the effects of supplementation with curcumin-piperine combination in patients with ischemic stroke in the rehabilitation stage. METHODS: In this randomized controlled trial, 66 patients with stroke were randomized into two groups receiving curcumin-piperine tablets (500 mg curcumin + 5 mg piperine) and matched placebo tablets for 12 weeks...
December 11, 2023: Nutrition Journal
https://read.qxmd.com/read/38073622/study-protocol-for-fibrokit-a-new-tool-for-fibromyalgia-diagnosis-and-patient-follow-up
#29
JOURNAL ARTICLE
Laura Lucena Del Amo, Elena Durán-González, Jorge A Ramírez-Tejero, Antonio Martínez-Lara, David Cotán
Fibromyalgia (FM) is a complex disease that is characterized by chronic musculoskeletal pain and has great economic impact. FM prevalence is about 2% to 4% worldwide, affecting mainly middle-aged women, and its complex pathophysiology complicates diagnosis, treatment and the findings of solid biomarkers. Previous studies have suggested an association between the disease and oxidative stress, mitochondrial metabolism, intestinal microbiota and inflammation, providing sufficient data to support the multifactorial origin of FM...
2023: Frontiers in Neurology
https://read.qxmd.com/read/38073153/nutrition-support-in-the-pediatric-total-pancreatectomy-with-islet-autotransplantation-recipient
#30
REVIEW
Elissa M Downs, Amanda Brun, Melena D Bellin
For children with diminished quality of life and chronic pain caused by acute recurrent or chronic pancreatitis who are undergoing total pancreatectomy with islet autotransplantation, postoperative nutrition support has several unique characteristics. Surgical complications may lead to delays in nutrition support initiation or require modifications to the regimen. Early postoperative dysmotility requires the use of temporary enteral nutrition until this improves. The resultant complete exocrine pancreatic insufficiency necessitates lifelong pancreatic enzyme replacement therapy and fat-soluble vitamin supplementation...
December 10, 2023: Nutrition in Clinical Practice
https://read.qxmd.com/read/38057020/is-intradialytic-oral-nutritional-supplementation-safe-and-effective-on-clinical-outcomes-a-systematic-review-with-conventional-meta-analysis-and-network-meta-analysis
#31
JOURNAL ARTICLE
Sonia López-Cisneros, Samuel Ramos-Acevedo, Ailema González-Ortiz, Alejandro G González-Garay, Aurora E Serralde-Zúñiga, Ángeles Espinosa-Cuevas
AIM: determine the effect of intradialytic oral nutrition (ION) on clinical and safety outcomes. DESIGN: Systematic Review with conventional Meta-analysis, and a Network Meta-analysis (NMA) as sensitivity analysis. We searched on MEDLINE, LILACS, CENTRAL, and EMBASE in June 2020, and the last update was until August 2022. We selected observational and randomized controlled trials with ION for at least four weeks. Primary outcomes were all-cause mortality and quality of life (QoL); adverse events, physical performance, and appetite were secondary outcomes...
December 2023: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38017500/the-jumpfood-study-additional-effect-of-hydrolyzed-collagen-and-vitamin-c-to-exercise-treatment-for-patellar-tendinopathy-jumper-s-knee-in-athletes-study-protocol-for-a-double-blind-randomized-controlled-trial
#32
JOURNAL ARTICLE
L van Dam, R Terink, M Mensink, R J de Vos, J Zwerver
BACKGROUND: Patellar tendinopathy (PT) is a common problem in jumping athletes. Management can be challenging and treatment outcome is not always successful. In combination with tendon loading exercises, hydrolyzed collagen/vitamin C supplementation appears to have a promising effect on the recovery of tendinopathy. The aim of this study is to evaluate whether the use of oral supplementation of hydrolyzed collagen and vitamin C in combination with progressive tendon loading exercises (PTLE) is superior to PTLE and placebo on VISA-P score (which rates pain, function, sports participation) after 24 weeks for athletes with PT...
November 28, 2023: Trials
https://read.qxmd.com/read/38011966/hidden-sodium-in-effervescent-tablet-dietary-supplements-and-over-the-counter-drugs-a-comparative-cross-sectional-study
#33
JOURNAL ARTICLE
Michael Kunz, Felix Götzinger, Cathy M Jacobs, Lucas Lauder, Christian Ukena, Markus R Meyer, Ulrich Laufs, Martin Schulz, Michael Böhm, Felix Mahfoud
OBJECTIVE: Dietary sodium intake represents a risk factor for cardiovascular disease and mortality. The study sought to analyse the sodium content of effervescent dietary supplements and drugs in Germany and the USA. DESIGN: Comparative cross-sectional study. SETTING AND METHODS: The sodium content of 39 dietary supplement effervescent tablets available in Germany was measured in May and June 2022 using optical emission spectrometry with inductively coupled argon plasma...
November 27, 2023: BMJ Open
https://read.qxmd.com/read/37949167/multimodal-prehabilitation-for-peripheral-arterial-disease-patients-with-intermittent-claudication-a-pilot-randomized-controlled-trial
#34
JOURNAL ARTICLE
Miquel Coca-Martinez, Elie Girsowicz, Robert J Doonan, Daniel I Obrand, Jason P Bayne, Oren K Steinmetz, Kent S Mackenzie, Francesco Carli, Graciela Martinez-Palli, Heather L Gill
OBJECTIVE: To establish the feasibility and safety of multimodal prehabilitation (MP), and to obtain pilot data on the change in quality of life, functional walking capacity, and the need for surgery for a full-scale trial. DESIGN: Pilot randomized controlled trial that included patients older than 50 years old suffering from moderate to severe intermittent claudication and who were candidates for endovascular revascularization (ER). Participants were excluded if they presented with ischemic rest pain, gangrene or ulceration of the index leg, significant lesions in the iliac vessels, planned surgical bypass, comorbidities in which exercise was contraindicated or if they were unable to speak English or French...
November 8, 2023: Annals of Vascular Surgery
https://read.qxmd.com/read/37914304/effects-of-eurycoma-longifolia-jack-standardised-water-extract-physta-on-well-being-of-perimenopausal-and-postmenopausal-women-protocol-for-a-randomised-double-blinded-placebo-controlled-parallel-group-study
#35
JOURNAL ARTICLE
Subashini Muniandy, Hanis Mastura Yahya, Suzana Shahar, Ixora Kamisan Atan, Zaleha Abdullah Mahdy, Nor Fadilah Rajab, Annie George, Sasikala M Chinnappan
INTRODUCTION: Eurycoma longifolia Jack (EL), profoundly recognised as 'Tongkat Ali', is a medicinal herb originating from Southeast Asia. It is commonly used in traditional 'antiageing' treatments to address decreased energy, mood, libido and hormonal imbalances. While the benefits of EL have been extensively studied among the male population, less attention has been given to its effects on women. Menopause can impact the overall well-being of middle-aged women and incorporation of herbal supplements can aid them in managing the menopausal symptoms...
November 1, 2023: BMJ Open
https://read.qxmd.com/read/37899826/safe-and-effective-delivery-of-supplemental-iron-to-healthy-adults-a-two-phase-randomized-double-blind-trial-the-safe-iron-study
#36
JOURNAL ARTICLE
Erin D Lewis, Edwin F Ortega, Maria Carlota Dao, Kathryn Barger, Joel B Mason, John M Leong, Marcia S Osburne, Loranne Magoun, Felix J Nepveux V, Athar H Chishti, Christopher Schwake, Anh Quynh, Cheryl H Gilhooly, Gayle Petty, Weimin Guo, Gregory Matuszek, Dora Pereira, Manju Reddy, Jifan Wang, Dayong Wu, Simin N Meydani, Gerald F Combs
INTRODUCTION: The safety of novel forms of iron in healthy, iron-replete adults as might occur if used in population-based iron supplementation programs was examined. We tested the hypotheses that supplementation with nanoparticulate iron hydroxide adipate tartrate (IHAT), an iron-enriched Aspergillus oryzae product (ASP), or ferrous sulphate heptahydrate (FS) are safe as indicated by erythrocyte susceptibility to malarial infection, bacterial proliferation, and gut inflammation. Responses to FS administered daily or weekly, and with or without other micronutrients were compared...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37836525/the-effect-of-nattokinase-monascus-supplements-on-dyslipidemia-a-four-month-randomized-double-blind-placebo-controlled-clinical-trial
#37
JOURNAL ARTICLE
Xiaoming Liu, Xuejiao Zeng, Jinli Mahe, Kai Guo, Panpan He, Qianwen Yang, Zhiwei Zhang, Zhongxia Li, Di Wang, Zheqing Zhang, Lei Wang, Lipeng Jing
Dyslipidemia, a condition implying high cardiovascular risks, has been widely studied on its potential nutrition interventions, including functional foods. This study aims to examine the effect of nattokinase monascus supplements (NMSs) on cardiovascular biomarkers and carotid intima-media thickness (CIMT) in patients with dyslipidemia. A total of 113 eligible subjects were randomly assigned to receive either NMSs or a placebo (55 and 58, respectively). After a 120-day intervention, there were significant mean absolute changes in total cholesterol (TC), low-density cholesterol (LDL-C), non-high-density cholesterol (non-HDL-C), and low-density cholesterol to high-density cholesterol ratio (LDL-C to HDL-C ratio), with values of -0...
September 30, 2023: Nutrients
https://read.qxmd.com/read/37824403/food-and-antioxidant-supplements-with-therapeutic-properties-of-morchella-esculenta-ascomycetes-a-review
#38
JOURNAL ARTICLE
Pushpa Kewlani, Deepti Tiwari, Laxman Singh, Shivani Balodi, Indra D Bhatt
Morchella esculenta, commonly known as yellow morels, is an edible and medicinal mushroom popular worldwide for its unique flavor and culinary purposes. The traditional medical system effectively uses morels against infertility, fatigue, cancer, muscular pain, cough, and cold. The M. esculenta possesses many health-promoting nutritional components such as mono and polyunsaturated fatty acids, polyphenols, protein hydrolysates, vitamins, amino acids and minerals. The potential medicinal properties of morels is due to polysaccharides (galactomannan, chitin, β-glucans, and β-1,3-1,6-glucan) present that has high economic importance worldwide...
2023: International Journal of Medicinal Mushrooms
https://read.qxmd.com/read/37813369/dietary-and-nutritional-supplementation-for-painful-diabetic-neuropathy-a-narrative-review
#39
REVIEW
Kyriaki Apergi, Nikolaos Papanas
Painful diabetic neuropathy (PDN) is a serious and very common complication of diabetes mellitus (DM). It negatively affects the quality of life, increases morbidity and poses a financial burden on the health care system. Currently, treatment of PDN focuses on glycaemic control, while pathogenesis-oriented therapy has not yielded satisfactory results. The need to improve therapy remains. There is accumulating evidence on the potential benefit of nutritional interventions. This narrative review aims to examine the potential benefit of dietary and nutritional supplementation for PDN management...
December 2023: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/37801459/-clinical-efficacy-of-a-modern-probiotic-for-the-correction-of-intestinal-microflora-in-patients-with-irritable-bowel-syndrome-with-diarrhea-and-antibiotic-associated-diarrhea
#40
JOURNAL ARTICLE
V N Drozdov, E V Shikh, A A Astapovskii, K N Khalaidzheva, S A Solovieva, O B Dorogun
Despite the fact that dietary supplements (DS) are not medicines, an increasing number of publications testify to the effectiveness of probiotics consumed with food in the complex treatment and prevention of a number of diseases of the gastrointestinal tract, including irritable bowel syndrome (IBS) and antibiotic-associated diarrhea (AAD). The purpose of the study was to evaluate the effectiveness of the complex probiotic in the relief of diarrheal syndrome associated with intestinal microbiota dysbiosis in patients with IBS with diarrhea and AAD...
2023: Voprosy Pitaniia
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