Erin D Lewis, Edwin F Ortega, Maria Carlota Dao, Kathryn Barger, Joel B Mason, John M Leong, Marcia S Osburne, Loranne Magoun, Felix J Nepveux V, Athar H Chishti, Christopher Schwake, Anh Quynh, Cheryl H Gilhooly, Gayle Petty, Weimin Guo, Gregory Matuszek, Dora Pereira, Manju Reddy, Jifan Wang, Dayong Wu, Simin N Meydani, Gerald F Combs
INTRODUCTION: The safety of novel forms of iron in healthy, iron-replete adults as might occur if used in population-based iron supplementation programs was examined. We tested the hypotheses that supplementation with nanoparticulate iron hydroxide adipate tartrate (IHAT), an iron-enriched Aspergillus oryzae product (ASP), or ferrous sulphate heptahydrate (FS) are safe as indicated by erythrocyte susceptibility to malarial infection, bacterial proliferation, and gut inflammation. Responses to FS administered daily or weekly, and with or without other micronutrients were compared...
2023: Frontiers in Nutrition