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https://www.readbyqxmd.com/read/29791486/involvement-of-the-renin-angiotensin-system-in-the-progression-of-severe-hand-foot-and-mouth-disease
#1
Chao Zhang, Shuaiyin Chen, Guangyuan Zhou, Yuefei Jin, Rongguang Zhang, Haiyan Yang, Yuanlin Xi, Jingchao Ren, Guangcai Duan
BACKGROUND: Hand-foot-and-mouth disease (HFMD) is generally considered as a mild exanthematous disease to infants and young children worldwide. HFMD cases are usually mild and self-limiting but for few cases leads to complicated severe clinical outcomes, and even death. Previous studies have indicated that serum Ang II levels in patients with H7N9 infection were related to the severity of infection. However, the mechanisms underlying the pathogenesis of severe HFMD remain unclear. This study was undertaken to clarify the role of the renin-angiotensin system (RAS) in the progression of severe HFMD...
2018: PloS One
https://www.readbyqxmd.com/read/29783814/-epidemiology-and-management-development-of-hand-foot-and-mouth-disease-in-chinese-mainland-a-ten-year-review
#2
S Y Qian, X W Li
No abstract text is available yet for this article.
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29778429/outcomes-following-severe-hand-foot-and-mouth-disease-a-systematic-review-and-meta-analysis
#3
Eben Jones, Timesh D Pillay, Fengfeng Liu, Li Luo, Juan Carlos Bazo-Alvarez, Chen Yuan, Shanlu Zhao, Qi Chen, Yu Li, Qiaohong Liao, Hongjie Yu, H Rogier van Doorn, Saraswathy Sabanathan
BACKGROUND: Hand, foot and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) is associated with acute neurological disease in children. This study aimed to estimate the burden of long-term sequelae and death following severe HFMD. METHODS: This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015...
April 20, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29777102/a-virus-like-particle-based-tetravalent-vaccine-for-hand-foot-and-mouth-disease-elicits-broad-and-balanced-protective-immunity
#4
Wei Zhang, Wenlong Dai, Chao Zhang, Yu Zhou, Pei Xiong, Shuxia Wang, Xiaohua Ye, Qingwei Liu, Dongming Zhou, Zhong Huang
Hand, foot, and mouth disease (HFMD) is an infectious disease that mainly affects infants and children, causing considerable morbidity and mortality worldwide. HFMD is commonly caused by enterovirus 71 (EV71) and coxsackieviruses A16 (CVA16), A6 (CVA6), and A10 (CVA10). Formalin-inactivated EV71 vaccines are currently available in China; however, these vaccines fail to confer cross-protection against infections by other HFMD-causing enteroviruses, highlighting the necessity of developing a multivalent HFMD vaccine...
May 18, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29776754/willingness-and-influential-factors-of-parents-to-vaccinate-their-children-with-novel-inactivated-enterovirus-71-vaccines-in-guangzhou-china
#5
Tiegang Li, Hui Wang, Yin Lu, Qin Li, Chun Chen, Dahu Wang, Meixia Li, Yilan Li, Jianyun Lu, Zongqiu Chen, Yu Ma, Wenhui Liu, Mengmeng Ma, Di Wu, Jiachun Lu, Zhicong Yang
Hand, foot and mouth disease (HFMD) primarily affects children younger than 5 years of age. Recently, HFMD has ranked as the top notifiable infectious disease in China. In December 2015, China approved two novel inactivated enterovirus 71 vaccines (EV71 vaccines) for HFMD. Parents' acceptance is often essential for vaccination program success. The goal of this study was to identify willingness and influential factors to vaccinate among parents of kindergarteners in Guangzhou, China. A cross-sectional survey of face-to-face interviews was conducted from March to July 2016...
May 15, 2018: Vaccine
https://www.readbyqxmd.com/read/29767300/development-and-evaluation-of-a-rapid-recombinase-polymerase-amplification-assay-for-the-detection-of-human-enterovirus-71
#6
Dan Yin, Yanan Zhu, Kaifeng Wang, Jing Wang, Xiru Zhang, Min Han, Yaqing He, Qing Chen, Guifang Hu
Enterovirus 71 (EV71) is one of the most common pathogens of hand, foot, and mouth disease (HFMD). A rapid reverse transcription recombinase polymerase amplification (RT-RPA) assay was established to detect EV71 subgenotype C4 (EV71-C4). The 95% detection limit of the RT-RPA was 3.767 log10 genomic copies (LGC)/reaction. The specificity was 100%. In a clinical sample evaluation, this approach demonstrated sufficient clinical performance when compared with a commercial RT-qPCR diagnostic kit. Thus, the RT-RPA assay may be a promising alternative for the detection of EV71-C4...
May 16, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29766552/hand-foot-and-mouth-disease-photolocalized-to-sunburn
#7
Morgan Murphrey, Samantha Casselman, Kevin B Yarbrough
Hand, foot, and mouth disease is a common exanthem linked to infection with several non-polio enteroviruses. This case of an 11-year-old boy with an enteroviral infection limited to areas of sunburn is an atypical presentation of hand, foot, and mouth disease. Recognition of this unusual distribution will allow pediatricians and pediatric dermatologists to appropriately manage and counsel patients and parents.
May 16, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29765110/mast-cells-contribute-to-enterovirus-71-infection-induced-pulmonary-edema-in-neonatal-mice
#8
Yuefei Jin, Chao Zhang, Hui Wang, Guangyuan Zhou, Xiangpeng Wang, Rongguang Zhang, Shuaiyin Chen, Jingchao Ren, Lu Chen, Dejian Dang, Peng Zhang, Yuanlin Xi, Weidong Wu, Weiguo Zhang, Guangcai Duan
Enterovirus (EV) 71 infection has been widely acknowledged as the leading cause of severe hand, foot and mouth disease (HFMD), which may rapidly lead to fatal pulmonary edema. In this study, we established a mouse model for EV71 infection exhibiting high incidence of severe symptoms with pulmonary edema. Mast cells (MCs) accumulation, activation and allergic inflammation were found in the brains, lungs and skeletal muscle of mice after EV71 infection, especially in the lungs of mice. Levels of histamine, platelet-activating factor (PAF), interleukin (IL)-4, IL-5, IL-13, tumor necrosis factor-α (TNF-α), nitric oxide (NO), endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and noradrenaline (NA) were increased in EV71-infected lungs...
May 15, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29763627/evaluation-of-minion-nanopore-sequencing-for-rapid-enterovirus-genotyping
#9
Emily Rames, Joanne Macdonald
Enteroviruses (EV) are associated with a range of serious infections, including aseptic meningitis, hand foot and mouth disease, myocarditis, acute flaccid paralysis and encephalitis. Improved methods for assessing EV genotypic diversity could assist molecular epidemiology studies, clinical diagnosis and environmental surveillance. We report new methods for EV genome amplification, and subsequent genotyping using the miniaturised MinION sequencing device. Importantly, this next-generation sequencer enabled correct strain-level assignment of identity for the EV-A71 isolate assessed, where strains with up to 99...
May 12, 2018: Virus Research
https://www.readbyqxmd.com/read/29758237/rapid-detection-of-hand-foot-and-mouth-disease-enterovirus-genotypes-by-multiplex-pcr
#10
Min Wang, Qian Ren, Zhenjie Zhang, Lehai Zhang, Michael J Carr, Juan Li, Hong Zhou, Weifeng Shi
Hand, foot and mouth disease (HFMD) is a pediatric disease associated with infection by enterovirus (EV) genotypes. The major HFMD EV pathogens are enterovirus A71 (EVA71) and coxsackievirus A16 (CVA16); however, recently, coxsackievirus A6 (CVA6) and coxsackievirus A10 (CVA10) have also emerged. EV genotypes cannot be distinguished on clinical grounds and a new methodology for the rapid detection of the four major HFMD EV genotypes is urgently required. In the present study, a multiplex real-time PCR assay was established for the simultaneous detection of CVA6, CVA10, CVA16 and EVA71...
May 11, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29755438/caspase-3-inhibition-attenuates-the-cytopathic-effects-of-ev71-infection
#11
Fengmei Song, Xiaoyan Yu, Ting Zhong, Zengyan Wang, Xiangling Meng, Zhaolong Li, Shuxia Zhang, Wenbo Huo, Xin Liu, Yahong Zhang, Wenyan Zhang, Jinghua Yu
Previous studies demonstrate that human enterovirus 71 (EV71), a primary causative agent for hand, foot, and mouth disease, activates caspase-3 through the non-structural viral 3C protein to induce host cell apoptosis; however, until now it was unclear how 3C activates caspase-3 and how caspase-3 activation affects viral production. Our results demonstrate that 3C binds caspase-8 and caspase-9 but does not directly bind caspase-3 to activate them, and that the proteolytic activity of 3C is required by the activation of caspase-8, caspase-9, and caspase-3...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29754884/circulating-salivary-mirna-hsa-mir-221-as-clinically-validated-diagnostic-marker-for-hand-foot-and-mouth-disease-in-pediatric-patients
#12
Nyo Min, Previtha Dawn Sakthi Vale, Anng Anng Wong, Natalie Woon Hui Tan, Chia Yin Chong, Chih-Jung Chen, Robert Y L Wang, Justin Jang Hann Chu
Enhancements in the diagnostic capabilities using host biomarkers are currently much needed where sensitivity and specificity issues plague the diagnosis of Hand, Foot and Mouth Disease (HFMD) in pediatrics clinical samples. We investigated miRNome profiles of HFMD saliva samples against healthy children and developed miRNA-based diagnosis models. Our 6-miRNA scoring model predicted HFMD with an overall accuracy of 85.11% in the training set and 92.86% in the blinded test set of Singapore cohort. Blinded evaluation of the model in Taiwan HFMD cases resulted in 77...
May 10, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29746455/enterovirus-and-parechovirus-surveillance-united-states-2014-2016
#13
Glen R Abedi, John T Watson, W Allan Nix, M Steven Oberste, Susan I Gerber
Infections caused by enteroviruses (EV) and parechoviruses (PeV), members of the Picornaviridae family, are associated with various clinical manifestations, including hand, foot, and mouth disease; respiratory illness; myocarditis; meningitis; and sepsis; and can result in death. The genus Enterovirus includes four species of enterovirus (A-D) known to infect humans, and the genus Parechovirus includes one species (A) that infects humans. These species are further divided into types, some of which are associated with specific clinical manifestations...
May 11, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29739716/the-immunogenicity-and-protection-effect-of-an-inactivated-coxsackievirus-a6-a10-and-a16-vaccine-against-hand-foot-and-mouth-disease
#14
Heeji Lim, Hyun Ju In, Jung-Ah Lee, Jung Sik Yoo, Sang-Won Lee, Gyung Tae Chung, Young Ki Choi, Jae Keun Chung, Sun Ju Cho, June-Woo Lee
Coxsackievirus belongs to the Enterovirus genus of the Picornaviridae family and is one of the major pathogens associated with human hand, foot, and mouth disease (HFMD). Historically, outbreaks of HFMD have mainly been caused by enterovirus 71 and coxsackievirus A16. Recently, coxsackieviruses A6 and A10 have been associated with increased occurrences of sporadic HFMD cases and outbreak events globally. In this study, the immunogenicity of coxsackieviruses A6, A10, and A16 (CA6, CA10, and CA16), which were inactivated by formalin or β-propiolactone (BPL) under different conditions, was evaluated as multivalent vaccine candidates...
May 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29734967/floods-increase-the-risks-of-hand-foot-mouth-disease-in-qingdao-china-2009-2013-a-quantitative-analysis
#15
Xiaowen Hu, Fachun Jiang, Wei Ni
BACKGROUND: We aimed to quantify the impact of few times floods on hand-foot-mouth disease (HFMD) in Qingdao during 2009-2013. METHODS: The Spearman correlation test was applied to examine the lagged effects of floods on monthly morbidity of HFMD during study period in Qingdao. We further quantified the effects of 5 flood events on the morbidity of HFMD using the time-series Poisson regression controlling for climatic factors, seasonality, and lagged effects among different populations...
May 8, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29726854/critical-anemia-%C3%A2-light-headedness-%C3%A2-bilateral-leg-swelling-%C3%A2-dx
#16
Maria Tecos, Megan Yee, Tricia Mueller
40-year-old man was referred to the emergency department (ED) with critical anemia after routine blood work at an outside clinic showed a hemoglobin level of 3.5 g/dL. On presentation, he reported symptoms of fatigue, shortness of breath, bilateral leg swelling, dizziness (characterized as light-headedness), and frequent heartburn. He said that the symptoms began 5 weeks earlier, after he was exposed to a relative with hand, foot, and mouth disease.
May 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29724230/correlation-analysis-on-serum-inflammatory-cytokine-level-and-neurogenic-pulmonary-edema-for-children-with-severe-hand-foot-mouth-disease
#17
Jin-Fang Sun, Hao-Lan Li, Bao-Xia Sun
OBJECTIVE: This study aims to discuss the correlation between serum inflammatory cytokines and neurogenic pulmonary edema (NPE) in children with severe hand-foot-mouth disease (HFMD). METHODS: A total of 89 patients with severe HFMD were enrolled into this study. These patients were divided into two groups, according to the presence of NPE: central nervous system disease (CNSD) group and NPE group. Serum IL-4, IL-10, IL-6, IL-17, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) levels were measured in patients by enzyme-linked immunosorbent assay at 1, 3, and 5 days after admission...
May 3, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29703921/mutations-in-vp1-and-5-utr-affect-enterovirus-71-virulence
#18
Ching-Kun Chang, Shang-Rung Wu, Ying-Chin Chen, Kuen-Jin Lee, Nai-Hsiang Chung, Yi-Ju Lu, Shu-Ling Yu, Chia-Chyi Liu, Yen-Hung Chow
Enterovirus 71 (EV71) is a major cause of hand, foot and mouth disease (HFMD). The current EV71 propagating in Vero (EV-V) or sub-passaged in RD (EV-R) cells was used as a pathogen. Interestingly, EV-R exhibited differential virulence; challenging human scavenger receptor class B2-expressing (hSCARB2-Tg) mice with EV71 revealed that EV-V was more virulent than EV-R: 100% of mice that received lethal amounts of EV-V died, while all the mice that received EV-R survived. Severe pathogenesis correlated with viral burdens and proinflammatory cytokine levels were observed in EV-V-challenged mice, but controversy in EV-R-challenged mice...
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29702280/crosstalk-between-toll-like-receptor-3-and-notch-signaling-contributes-to-cd14-monocytes-activity-in-enterovirus-71-infected-hand-foot-and-mouth-disease
#19
Jie Hao, Peiling Li, Yunjiao Tian, Yanhua Wang, Suqing Li, Lina Wang, Shujun Li
Interaction between Toll-like receptor (TLR) and Notch signaling contributes to inflammatory response in nephropathy and fungicidal infection, however, the role of this crosstalk remains not fully elucidated in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). The aim of this study was to investigate the crosstalk between TLR and Notch in inflammatory regulation in EV71 infection. Thirty-seven EV-71-indcued HFMD (16 mild and 21 severe cases) and eleven normal control (NC) were enrolled. CD14+ monocytes were purified, and were stimulated with either TLR3/4 agonists [poly(I: C) or LPS] or Notch signaling inhibitor...
April 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29694053/potency-of-a-scalable-nanoparticulate-subunit-vaccine
#20
Dongdong Qiao, Lixin Liu, Yi Chen, Chenbao Xue, Qiang Gao, Hai-Quan Mao, Kam W Leong, Yongming Chen
Nanoparticulate vaccines can potentiate immune responses by site-specific drainage to lymph nodes (LNs). This approach may benefit from a nanoparticle engineering method with fine control over size and co-delivery of antigen and adjuvant. Here, we applied the flash nanocomplexation (FNC) method to prepare nanovaccines via polyelectrolyte complexation of chitosan and heparin to co-encapsulate the VP1 protein antigen from enterovirus 71, which causes hand-foot-mouth disease (HFMD), with tumor necrosis factor α (TNF) or CpG as adjuvants...
April 25, 2018: Nano Letters
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