keyword
MENU ▼
Read by QxMD icon Read
search

hfmd

keyword
https://www.readbyqxmd.com/read/28938017/a-highly-conserved-amino-acid-in-vp1-regulates-maturation-of-enterovirus-71
#1
Yong-Xin Zhang, Yu-Ming Huang, Quan-Jie Li, Xiao-Yu Li, Yong-Dong Zhou, Fei Guo, Jin-Ming Zhou, Shan Cen
Enterovirus 71 (EV71) is the major causative agent of hand, foot and mouth disease (HFMD) in children, causing severe clinical outcomes and even death. Here, we report an important role of the highly conserved alanine residue at position 107 in the capsid protein VP1 (VP1A107) in the efficient replication of EV71. Substitutional mutations of VP1A107 significantly diminish viral growth kinetics without significant effect on viral entry, expression of viral genes and viral production. The results of mechanistic studies reveal that VP1A107 regulates the efficient cleavage of the VP0 precursor during EV71 assembly, which is required, in the next round of infection, for the transformation of the mature virion (160S) into an intermediate or A-particle (135S), a key step of virus uncoating...
September 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28934232/economic-costs-and-health-related-quality-of-life-for-hand-foot-and-mouth-disease-hfmd-patients-in-china
#2
Yaming Zheng, Mark Jit, Joseph T Wu, Juan Yang, Kathy Leung, Qiaohong Liao, Hongjie Yu
BACKGROUND: Hand, foot and mouth disease (HFMD) is a common illness in China that mainly affects infants and children. The objective of this study is to assess the economic cost and health-related quality of life associated with HFMD in China. METHOD: A telephone survey of caregivers were conducted in 31 provinces across China. Caregivers of laboratory-confirmed HFMD patients who were registered in the national HFMD enhanced surveillance database during 2012-2013 were invited to participate in the survey...
2017: PloS One
https://www.readbyqxmd.com/read/28932658/the-process-of-wrapping-virus-revealed-by-a-force-tracing-technique-and-simulations
#3
Yangang Pan, Fuxian Zhang, Liuyang Zhang, Shuheng Liu, Mingjun Cai, Yuping Shan, Xianqiao Wang, Hanzhong Wang, Hongda Wang
Viral entry into the host cell is the first step of virus infection; however, its dynamic process via endocytosis remains largely elusive. Here, the force tracing technique and single particle simulation are combined to investigate the invagination of single human enterovirus 71 (HEV71, a positive single-stranded RNA virus that is associated with hand, foot, and mouth disease) via cell membranes during its host cell entry. The experimental results reveal that the HEV71 invaginates in membrane vesicles at a force of 58 ± 16 pN, a duration time of 278 ± 68 ms...
September 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28931688/a-selective-bottleneck-shapes-the-evolutionary-mutant-spectra-of-enterovirus-a71-during-viral-dissemination-in-humans
#4
Sheng-Wen Huang, Yi-Hui Huang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Jen-Ren Wang
RNA viruses accumulate mutations to rapidly adapt to environmental changes. Enterovirus A71 (EV-A71) causes various clinical manifestations with occasional severe neurological complications. However, the mechanism by which EV-A71 evolves within the human body is unclear. Utilizing deep sequencing and haplotype analyses of viruses from various tissues of an autopsy patient, we sought to define the evolutionary pathway by which enterovirus A71 evolves fitness for invading the central nervous system in humans...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28914333/-acute-skin-infections-and-their-imitators-in-children-a-photo-quiz
#5
REVIEW
M Theiler, A Schwieger-Briel, L Weibel
BACKGROUND: Skin infections account for 40% of emergency visits in pediatric dermatology. It is important to promptly recognize skin infections with potential complications and initiate treatment. However some characteristic skin findings may imitate skin infections and are often misdiagnosed. OBJECTIVES: To illustrate frequent pediatric skin infections and pitfalls in view of imitators and differential diagnoses. MATERIALS AND METHODS: A photo quiz is presented with the discussion of a selection of acute pediatric skin infections in comparison to their infectious or noninfectious differential diagnoses...
September 15, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28910932/-downscaling-research-of-spatial-distribution-of-incidence-of-hand-foot-and-mouth-disease-based-on-area-to-area-poisson-kriging-method
#6
J X Wang, M G Hu, S C Yu, G X Xiao
Objective: To understand the spatial distribution of incidence of hand foot and mouth disease (HFMD) at scale of township and provide evidence for the better prevention and control of HFMD and allocation of medical resources. Methods: The incidence data of HFMD in 108 counties (district) in Shandong province in 2010 were collected. Downscaling interpolation was conducted by using area-to-area Poisson Kriging method. The interpolation results were visualized by using geographic information system (GIS). The county (district) incidence was interpolated into township incidence to get the distribution of spatial distribution of incidence of township...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28898935/monitoring-hand-foot-and-mouth-disease-by-combining-search-engine-query-data-and-meteorological-factors
#7
Da-Cang Huang, Jin-Feng Wang
Hand, foot and mouth disease (HFMD) has been recognized as a significant public health threat and poses a tremendous challenge to disease control departments. To date, the relationship between meteorological factors and HFMD has been documented, and public interest of disease has been proven to be trackable from the Internet. However, no study has explored the combination of these two factors in the monitoring of HFMD. Therefore, the main aim of this study was to develop an effective monitoring model of HFMD in Guangzhou, China by utilizing historical HFMD cases, Internet-based search engine query data and meteorological factors...
September 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28894095/atomic-structures-of-coxsackievirus-a6-and-its-complex-with-a-neutralizing-antibody
#8
Longfa Xu, Qingbing Zheng, Shaowei Li, Maozhou He, Yangtao Wu, Yongchao Li, Rui Zhu, Hai Yu, Qiyang Hong, Jie Jiang, Zizhen Li, Shuxuan Li, Huan Zhao, Lisheng Yang, Wangheng Hou, Wei Wang, Xiangzhong Ye, Jun Zhang, Timothy S Baker, Tong Cheng, Z Hong Zhou, Xiaodong Yan, Ningshao Xia
Coxsackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldwide but no vaccine is available against CVA6 infections. Here, we demonstrate the isolation of two forms of stable CVA6 particles-procapsid and A-particle-with excellent biochemical stability and natural antigenicity to serve as vaccine candidates. Despite the presence (in A-particle) or absence (in procapsid) of capsid-RNA interactions, the two CVA6 particles have essentially identical atomic capsid structures resembling the uncoating intermediates of other enteroviruses...
September 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28893485/-clinical-characteristics-and-course-of-hand-foot-and-mouth-disease
#9
A Mirand, H Peigue-Lafeuille
Hand, foot and mouth disease (HFMD) and herpangina (HA) are common childhood diseases mostly associated with human enteroviruses (EV). Although usually benign illnesses, neurological complications may be observed during large epidemics when enterovirus A71 (EV-A71) is involved, as observed in the Asia Pacific Region and in China since the late 1990s. The occurrence of these complications warrants reinforcing the surveillance of the emergence of EV-A71 infections in France and Europe. Monitoring EV infections associated with HFMD can be considered as an effective tool to detect an upsurge of EV-A71 infections in a timely manner...
September 8, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28892475/cost-effectiveness-of-a-national-enterovirus-71-vaccination-program-in-china
#10
Wenjun Wang, Jianwen Song, Jingjing Wang, Yaping Li, Huiling Deng, Mei Li, Ning Gao, Song Zhai, Shuangsuo Dang, Xin Zhang, Xiaoli Jia
BACKGROUND AND AIMS: Enterovirus 71 (EV71) has caused great morbidity, mortality, and use of health service in children younger than five years in China. Vaccines against EV71 have been proved effective and safe by recent phase 3 trials and are now available in China. The purpose of this study was to evaluate the health impact and cost-effectiveness of a national EV71 vaccination program in China. METHODS: Using Microsoft Excel, a decision model was built to calculate the net clinical and economic outcomes of EV71 vaccination compared with no EV71 vaccination in a birth cohort of 1,000,000 Chinese children followed for five years...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28891456/spatiotemporal-risk-mapping-of-hand-foot-and-mouth-disease-and-its-association-with-meteorological-variables-in-children-under-5-years
#11
C D Xu, G X Xiao
Hand, foot and mouth disease (HFMD) risk has become an increasing concern in the Beijing-Tianjin-Hebei region, which is the biggest urban agglomeration in north-eastern Asia. In the study, spatiotemporal epidemiological features of HFMD were analysed, and a Bayesian space-time hierarchy model was used to detect local spatial relative risk (RR) and to assess the effect of meteorological factors. From 2009 to 2013, there was an obvious seasonal pattern of HFMD risk. The highest risk period was in the summer, with an average monthly incidence of 4·17/103, whereas the index in wintertime was 0·16/103...
September 11, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28890503/spatial-clustering-of-severe-hand-foot-mouth-disease-cases-in-hainan-island-china
#12
Shao-Ming Chen, Li Qiu, Zhong-Hua Du, Yu-Ming Jin, Jian-Wei Du, Yan Chen, Chiho Watanabe, Masahiro Umezaki
  The incidence of severe Hand-Foot-Mouth disease (HFMD) in Southeast/East Asia has recently increased. This study explored spatial clusters of the incidence and proportion of severe HFMD cases in Hainan Island, Where the prevalence and mortality of HFMD were the highest in China in 2011. A spatial autocorrelation statistic (Anselin's Local Moran I) was calculated for the Empirical Bayesian (EB) smoothed dataset of severe HFMD cases. Significantly spatial clusters were detected for both incidence and the proportion of severe HFMD cases...
September 11, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28882666/clinical-features-for-89-deaths-of-hand-foot-and-mouth-disease-in-guangxi-china-2014
#13
Wei Lin, Ying Su, Min Jiang, Jing Liu, Yan-Yan Zhang, Guang-Min Nong
OBJECTIVES: The aim of this study is to summarize the risk factors of severe Hand, foot and mouth disease (HFMD) and explore the clinical characteristics of pulmonary edema (PE) and non-PE in the deceased patients with HFMD. METHODS: We identified 89 HFMD deaths which were separated into the PE group or non-PE group. Next, patients were divided based on their initial admission to hospitals as stage 1, 2, 3, or 4; at this point, their clinical manifestations were compared...
September 4, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28871120/development-of-a-luciferase-based-biosensor-to-assess-enterovirus-71-3c-protease-activity-in-living-cells
#14
Yuan Zhang, Xianliang Ke, Caishang Zheng, Yan Liu, Li Xie, Zhenhua Zheng, Hanzhong Wang
Enterovirus 71 (EV71) is a major pathogen of hand, foot, and mouth disease (HFMD). To date, no antiviral drug has been approved to treat EV71 infection. Due to the essential role that EV71 3 C protease (3C(pro)) plays in the viral life cycle, it is generally considered as a highly appealing target for antiviral drug development. In this study, we present a transgene-encoded biosensor that can accurately, sensitively and quantitatively report the proteolytic activity of EV71 3C(pro). This biosensor is based on the catalyzed activity of a pro-interleukin (IL)-1β-enterovirus 3C(pro) cleavage site-Gaussia Luciferase (GLuc) fusion protein that we named i-3CS-GLuc...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28867629/a-nanobiosensing-method-based-on-force-measurement-of-antibody-antigen-interaction-for-direct-detection-of-enterovirus-71-by-the-chemically-modified-atomic-force-microscopic-probe
#15
Chung-Hung Hong, Chung-Fan Hsieh, Chi-Shin Tseng, Wei-Chih Huang, Cheng-Yan Guo, Shiming Lin, Si-Chen Lee
Hand, Foot and mouth disease (HFMD) is a common disease with high infectivity for children, and enterovirus 71 (EV71) is one of the main pathogens to cause the type of illness. Therefore, the aim of this study was to propose a rapid and effective technique for detecting EV71 directly based on the mechanism of biological intermolecular force by using atomic force microscopy (AFM). At first, we coated EV71 particles on the mica surface and made the EV71 antibodies (anti-EV71) fixed on the AFM tip by means of several chemical procedures...
September 1, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28866699/a-sudden-paediatric-death-due-to-hand-foot-and-mouth-disease-the-importance-of-vigilance
#16
R Rahimi, E Omar, T S Tuan Soh, S F A Mohd Nawi, S Md Noor
BACKGROUND: Hand, foot and mouth disease (HFMD) is caused by enteroviruses such as Coxsackie virus A16 (CVA16) and Enterovirus 71 (EV71). The diagnostic hallmarks are oral ulcers and maculo-papular or vesicular rash on the hands and feet. Severe form of this disease can lead to death due to neurological and cardiopulmonary complications. This case report aims to describe a fatal case of HFMD with minimal oral and skin manifestations. CASE REPORT: A four-year-old girl was brought to a hospital after suddenly becoming unresponsive at home...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28864155/large-scale-hfmd-epidemics-caused-by-coxsackievirus-a16-in-bangalore-india-during-2013-and-2015
#17
Rao C Durga, Naidu R Jagadeesh, Maiya P Padmanabha, M Ananda Babu, Bailly Jean-Luc
Hand foot and mouth disease (HFMD) is a relatively unreported disease in India. This study was undertaken to characterize the enterovirus type/s associated with two unexpectedly-massive epidemics that occurred in Bangalore, India in 2013 and 2015. Stool samples of 229 children with HFMD living in Northern and Southern areas of Bangalore were tested by RT-PCR; 189 (82.5%) were enterovirus positive. The Indian CV-A16 strains exhibited 98-99% sequence identity with those reported in France and China in the 5' untranslated region...
August 29, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28854257/hrs-plays-an-important-role-for-tlr7-signaling-to-orchestrate-inflammation-and-innate-immunity-upon-ev71-infection
#18
Zhen Luo, Maolin Ge, Junbo Chen, Qibin Geng, Mingfu Tian, Zhi Qiao, Lan Bai, Qi Zhang, Chengliang Zhu, Ying Xiong, Kailang Wu, Fang Liu, Yingle Liu, Jianguo Wu
Enterovirus 71 (EV71) is an RNA virus that causes hand-foot-mouth disease (HFMD), and even fatal encephalitis in children. Although EV71 pathogenesis remains largely obscure, host immune responses may play important roles in the development of diseases. Recognition of pathogens mediated by Toll-like receptors (TLRs) induces host immune and inflammatory responses. Intracellular TLRs must traffic from the endoplasmic reticulum (ER) to the endolysosomal network from where they initiate complete signaling, leading to inflammatory response...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28845247/a52%C3%A2-development-and-evaluation-of-a-viral-specific-random-pcr-and-next-generation-sequencing-based-assay-for-detection-and-sequencing-of-hand-foot-and-mouth-disease-pathogens
#19
Nguyen To Anh, Tran Tan Thanh, Hoang Minh Tu Van, Nghiem My Ngoc, Le Nguyen Truc Nhu, Le Thi My Thanh, Phan Tu Qui, Truong Huu Khanh, Le Nguyen Thanh Nhan, Ho Lu Viet, Do Chau Viet, Ha Manh Tuan, Nguyen Thanh Hung, Nguyen Van Vinh Chau, Guy Thwaites, H Rogier van Doorn, Le Van Tan
No abstract text is available yet for this article.
March 2017: Virus Evolution
https://www.readbyqxmd.com/read/28843383/il-10-592-polymorphism-is-associated-with-il-10-expression-and-severity-of-enterovirus-71-infection-in-chinese-children
#20
Na Zhao, Hui-Lan Chen, Zhen-Zhen Chen, Jing Li, Zong-Bo Chen
BACKGROUND: Enterovirus 71 (EV71) infection results in some severe complications with high mortality and disability in Hand, Foot and Mouth Disease (HFMD) in children. Recent studies have shown that cytokine genetic predispositions have associations with both the development of EV71 infection and severity of HFMD. OBJECTIVE: This study was designed to investigate whether the IL-10-592 polymorphism is associated with IL-10 levels and disease severity in Chinese children with EV71 infection...
August 19, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
keyword
keyword
29392
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"