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https://www.readbyqxmd.com/read/29469676/the-glittre-adl-test-cut-off-point-to-discriminate-abnormal-functional-capacity-in-patients-with-copd
#1
Aline Almeida Gulart, Anelise Bauer Munari, Suelen Roberta Klein, Lucas Santos da Silveira, Anamaria Fleig Mayer
The study objective was to determine a cut-off point for the Glittre activities of daily living (ADL)test (TGlittre) to discriminate patients with normal and abnormal functional capacity. Fifty-nine patients with moderate to very severe COPD (45 males; 65 ± 8.84 years; BMI: 26 ± 4.78 kg/m2 ; FEV1 : 35.3 ± 13.4% pred) were evaluated for spirometry, TGlittre, 6-minute walk test (6 MWT), physical ADL, modified Medical Research Council scale (mMRC), BODE index, Saint George's Respiratory Questionnaire (SGRQ), and COPD Assessment Test (CAT)...
February 2018: COPD
https://www.readbyqxmd.com/read/29463285/network-modules-uncover-mechanisms-of-skeletal-muscle-dysfunction-in-copd-patients
#2
Ákos Tényi, Isaac Cano, Francesco Marabita, Narsis Kiani, Susana G Kalko, Esther Barreiro, Pedro de Atauri, Marta Cascante, David Gomez-Cabrero, Josep Roca
BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients often show skeletal muscle dysfunction that has a prominent negative impact on prognosis. The study aims to further explore underlying mechanisms of skeletal muscle dysfunction as a characteristic systemic effect of COPD, potentially modifiable with preventive interventions (i.e. muscle training). The research analyzes network module associated pathways and evaluates the findings using independent measurements. METHODS: We characterized the transcriptionally active network modules of interacting proteins in the vastus lateralis of COPD patients (n = 15, FEV1 46 ± 12% pred, age 68 ± 7 years) and healthy sedentary controls (n = 12, age 65 ± 9 years), at rest and after an 8-week endurance training program...
February 20, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29451226/final-adult-height-and-endocrine-complications-in-young-adults-with-%C3%AE-thalassemia-major-tm-who-received-oral-iron-chelation-oic-in-comparison-with-those-who-did-not-use-oic
#3
Ashraf T Soliman, Mohamed A Yassin, Vincenzo De Sanctis
BACKGROUND: Relatively little is known about endocrine function, bone mineral health, and growth during oral iron chelation therapy in β-thalassemia major patients (TM) on treatment with deferasirox. AIMS OF THE STUDY: To study the frequency of endocrine complications, IGF-1 levels and final adult standing height (FA-Ht) in patients with BTM in two groups of adult patients. PATIENTS AND METHODS: The first group (Group A; 15 patients, 6 females and 9 males) received oral iron chelation therapy (OIC) with deferasirox for 6 years before puberty; the second group (Group B;40 patients) attained the FA-Ht before the use of OIC (iron chelation therapy with deferoxamine (DFO) given subcutaneously, since the age of 2 years)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29429028/molecules-of-damage-associated-patterns-in-bronchoalveolar-lavage-fluid-and-serum-in-chronic-obstructive-pulmonary-disease
#4
Beata Brajer-Luftmann, Agata Nowicka, Mariusz Kaczmarek, Magdalena Wyrzykiewicz, Senan Yasar, Tomasz Piorunek, Marcin Grabicki, Magdalena Kostrzewska, Jan Sikora, Halina Batura-Gabryel
Chronic exposure to detrimental environmental factors may induce immunogenic cell death of structural airway cells in chronic obstructive pulmonary disease (COPD). Damage-associated molecular patterns (DAMPs) is a family of heterogeneous molecules released from injured or dead cells, which activate innate and adaptive immune responses on binding to the pattern recognition receptors on cells. This study seeks to define the content of DAMPs in the bronchoalveolar lavage fluid (BALF) and serum of COPD patients, and the possible association of these molecules with clinical disease features...
February 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29404900/body-composition-and-sarcopenia-in-patients-with-chronic-obstructive-pulmonary-disease
#5
Tatiana Munhoz da Rocha Lemos Costa, Fabio Marcelo Costa, Thaísa Hoffman Jonasson, Carolina Aguiar Moreira, César Luiz Boguszewski, Victória Zeghbi Cochenski Borba
PURPOSE: Changes in body composition are commonly present in chronic obstructive pulmonary disease (COPD). The main aim of this study were to evaluate changes in body composition and the prevalence of pre-sarcopenia and sarcopenia in patients with COPD, compared with two control groups and correlate these parameters with indices of COPD severity (VEF1 and GOLD) and prognosis (BODE). METHODS: This was a cross-sectional study in COPD patients (DG) that undergone body composition assessment by DXA...
February 5, 2018: Endocrine
https://www.readbyqxmd.com/read/29361320/medical-care-according-to-risk-level-and-adaptation-to-spanish-copd-guidelines-gesepoc-the-epoconsul-study
#6
Myriam Calle Rubio, Juan Luis Rodríguez Hermosa, Juan José Soler-Cataluña, José Luis López-Campos, Bernardino Alcazar Navarrete, Joan B Soriano, José Miguel Rodríguez Gónzalez-Moro, Manuel E Fuentes Ferrer, Marc Miravitlles
INTRODUCTION: EPOCONSUL is the first national audit to analyze medical care for COPD in pulmonology departments in Spain. The main objective was to perform a retrospective analysis to determine the distribution of GesEPOC 2017 COPD risk levels and to evaluate clinical activity according to the new recommendations. MATERIAL AND METHODS: This is a cross-sectional clinical audit in which consecutive COPD cases were recruited over one year. The study evaluated risk and clinical phenotype according to GesEPOC 2017, and their correlation with the clinical interventions employed...
January 17, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29343952/understanding-of-copd-among-final-year-medical-students
#7
Javier Mohigefer, Carmen Calero-Acuña, Eduardo Marquez-Martin, Francisco Ortega-Ruiz, Jose Luis Lopez-Campos
Objective: Several previous studies have shown a suboptimal level of understanding of COPD among different population groups. Students in their final year of Medicine constitute a population that has yet to be explored. The evaluation of their understanding provides an opportunity to establish strategies to improve teaching processes. The objective of the present study is to determine the current level of understanding of COPD among said population. Methods: A cross-sectional observational study was done using digital surveys given to medical students in their final year at the Universidad de Sevilla...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29326333/comet-a-multicomponent-home-based-disease-management-programme-versus-routine-care-in-severe-copd
#8
Romain Kessler, Pere Casan-Clara, Dieter Koehler, Silvia Tognella, Jose Luis Viejo, Roberto W Dal Negro, Salvador Díaz-Lobato, Karina Reissig, José Miguel Rodríguez González-Moro, Gilles Devouassoux, Jean-Michel Chavaillon, Pierre Botrus, Jean-Michel Arnal, Julio Ancochea, Anne Bergeron-Lafaurie, Carlos De Abajo, Winfried J Randerath, Andreas Bastian, Christian G Cornelissen, Georg Nilius, Joëlle B Texereau, Jean Bourbeau
The COPD Patient Management European Trial (COMET) investigated the efficacy and safety of a home-based COPD disease management intervention for severe COPD patients.The study was an international open-design clinical trial in COPD patients (forced expiratory volume in 1 s <50% of predicted value) randomised 1:1 to the disease management intervention or to the usual management practices at the study centre. The disease management intervention included a self-management programme, home telemonitoring, care coordination and medical management...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29322375/predictors-of-short-term-lama-ineffectiveness-in-treatment-na%C3%A3-ve-patients-with-moderate-to-severe-copd
#9
Vladimir Fijačko, Marina Labor, Mirjana Fijačko, Sanda Škrinjarić-Cincar, Slavica Labor, Iva Dumbović Dubravčić, Tatjana Bačun, Aleksandar Včev, Sanja Popović-Grle, Davor Plavec
BACKGROUND: No specific (only subgroup) recommendations for the use of long-acting muscarinic antagonists in chronic obstructive pulmonary disease (COPD) exist. The aim of this exploratory hypothesis generating study was to assess whether different phenotypic/endotypic characteristics could be determinants of the short-term ineffectiveness of the initial tiotropium bromide monotherapy in treatment naïve moderate to severe COPD patients. METHODS: A total of 51 consecutively recruited COPD patients were followed for 3 months after the initial evaluation and prescribed initial treatment (tiotropium)...
January 10, 2018: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29319032/study-of-inflammatory-markers-and-bode-index-in-chronic-obstructive-pulmonary-disease
#10
Priti Lokesh Meshram, Shivprasad N Shinde, Nagsen N Ramraje, Rohit R Hegde
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease characterized by progressive airflow limitation and associated with enhanced chronic inflammatory response of the airways to a variety of noxious stimuli. The current concept of COPD, however, extends beyond the respiratory system to include a variety of extrapulmonary manifestations which includes raised inflammatory markers. METHODS: This was a single, center observational open-labeled case-controlled study which included fifty patients of diagnosed COPD and 50 age- and gender-matched controls...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29319031/association-of-comorbid-anxiety-and-depression-with-chronic-obstructive-pulmonary-disease
#11
Ruchi Dua, Anindya Das, Abhishek Kumar, Sandeep Kumar, Mayank Mishra, Kapil Sharma
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a disease with known systemic manifestations including psychiatric comorbidities most commonly being depression and/or anxiety. Studies regarding the association of these psychiatric comorbidities in terms of symptom scores, spirometric variables, and hospitalizations among patients of COPD are lacking, especially in India. MATERIALS AND METHODS: One hundred and twenty-eight patients of COPD attending the Outpatient Department of AIIMS Rishikesh, and fulfilling inclusion criteria were screened by Hospital Anxiety and Depression Scale, and those who scored above the cutoff underwent psychiatric evaluation using the International Classification of Diseases, Tenth Edition Diagnostic Criteria for Research for confirmation of their diagnosis...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29227305/lung-transplantation-for-chronic-obstructive-pulmonary-disease-past-present-and-future-directions
#12
Faisal M Siddiqui, Joshua M Diamond
PURPOSE OF REVIEW: Lung transplantation offers an effective treatment modality for patients with end-stage chronic obstructive pulmonary disease (COPD). The exact determination of when to refer, list, and offer transplant as well as the preferred transplant procedure type remains unclear. Additionally, there are special considerations specific to patients with COPD being considered for lung transplantation, including the implications of single lung transplantation on lung cancer risk, native lung hyperinflation, and overall survival...
March 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29221293/distance-saturation-product-of-the-6-minute-walk-test-predicts-mortality-of-patients-with-non-cystic-fibrosis-bronchiectasis
#13
Meng-Heng Hsieh, Yueh-Fu Fang, Fu-Tsai Chung, Chung-Shu Lee, Yu-Chen Chang, Yuan-Zhang Liu, Cheng-Hsien Wu, Horng-Chyuan Lin
Background: Previous surveillance methods to monitor the prognoses of patients with bronchiectasis are too complex for use in daily practice. The 6-minute walk test (6MWT) is a simple exercise test to predict the prognosis of chronic obstructive airway disease and numerous chronic lung diseases, including idiopathic pulmonary fibrosis. No studies have investigated exercise-induced oxygen desaturation (EID) and distance-saturation product (DSP) of 6MWT to predict the prognoses of patients with bronchiectasis...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29213313/agronomic-performance-of-populus-deltoides-trees-engineered-for-biofuel-production
#14
David Macaya-Sanz, Jin-Gui Chen, Udaya C Kalluri, Wellington Muchero, Timothy J Tschaplinski, Lee E Gunter, Sandra J Simon, Ajaya K Biswal, Anthony C Bryan, Raja Payyavula, Meng Xie, Yongil Yang, Jin Zhang, Debra Mohnen, Gerald A Tuskan, Stephen P DiFazio
Background: One of the major barriers to the development of lignocellulosic feedstocks is the recalcitrance of plant cell walls to deconstruction and saccharification. Recalcitrance can be reduced by targeting genes involved in cell wall biosynthesis, but this can have unintended consequences that compromise the agronomic performance of the trees under field conditions. Here we report the results of a field trial of fourteen distinct transgenic Populus deltoides lines that had previously demonstrated reduced recalcitrance without yield penalties under greenhouse conditions...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29169250/clinical-effects-of-cognitive-impairment-in-patients-with-chronic-obstructive-pulmonary-disease
#15
Esra Ertan Yazar, Senay Aydin, Gulsah Gunluoglu, Sadettin Kamat, Adil Can Gungen, Pinar Yildiz
The aim of this study was to evaluate the clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease (COPD). A total of 91 patients with stable moderate to very severe COPD were included in this study. Cognitive functions of the patients were evaluated using the mini-mental state examination (MMSE) tool and clock-drawing test. The Brody's Instrumental Activities of Daily Living (IADL) Questionnaire; COPD assessment test (CAT); body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE); and Charlson comorbidity index were assessed...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29099607/comparison-of-2017-and-2015-global-initiative-for-obstructive-lung-disease-impact-on-grouping-and-outcomes
#16
Carlos Cabrera López, Ciro Casanova Macario, José María Marín Trigo, Juan P de-Torres, Rebeca Sicilia Torres, Jesús María González, Francesca Polverino, Miguel Divo, Victor Pinto Plata, Javier J Zulueta, Bartolomé Celli
INTRODUCTION: The GOLD document has modified the grading system directing pharmacotherapy. But how this relates to the previous one of 2015 and to comorbidities, hospitalizations and mortality risk is unknown. METHODS: We prospectively enrolled and followed for a mean of 5 years, 819 COPD patients (84% male) in clinics in Spain and the United States. We determined anthropometrics, lung function (FEV1%), dyspnea score (mMRC), ambulatory and hospital exacerbations, the BODE and Charlson indexes...
November 3, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29066436/interleukin-6-and-the-risk-of-adverse-outcomes-in-patients-after-an-acute-coronary-syndrome-observations-from-the-solid-timi-52-stabilization-of-plaque-using-darapladib-thrombolysis-in-myocardial-infarction-52-trial
#17
Christina L Fanola, David A Morrow, Christopher P Cannon, Petr Jarolim, Mary Ann Lukas, Christoph Bode, Judith S Hochman, Erica L Goodrich, Eugene Braunwald, Michelle L O'Donoghue
BACKGROUND: Interleukin-6 (IL-6) is an inflammatory cytokine implicated in plaque instability in acute coronary syndrome (ACS). We aimed to evaluate the prognostic implications of IL-6 post-ACS. METHODS AND RESULTS: IL-6 concentration was assessed at baseline in 4939 subjects in SOLID-TIMI 52 (Stabilization of Plaque Using Darapladib-Thrombolysis in Myocardial Infarction 52), a randomized trial of darapladib in patients ≤30 days from ACS. Patients were followed for a median of 2...
October 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29054348/survival-of-lung-transplant-candidates-with-copd-bode-score-reconsidered
#18
Robert M Reed, Howard J Cabral, Mark T Dransfield, Michael Eberlein, Christian A Merlo, Matthew J Mulligan, Giora Netzer, Pablo G Sanchez, Steven M Scharf, Don D Sin, Bartholome R Celli
BACKGROUND: The BMI, obstruction, dyspnea, and exercise capacity (BODE) score is used to inform prognostic considerations for lung transplantation for COPD, but it has not been validated in this context. A large proportion of mortality in COPD is attributable to comorbidities that could preclude transplant candidacy. We hypothesized that patients with COPD who are selected as transplant candidates experience better survival than traditional interpretation of BODE scores might indicate...
October 17, 2017: Chest
https://www.readbyqxmd.com/read/28993705/a-vicious-loop-of-fatty-acid-binding-protein-4-and-dna-methyltransferase-1-promotes-acute-myeloid-leukemia-and-acts-as-a-therapeutic-target
#19
F Yan, N Shen, J X Pang, N Zhao, Y W Zhang, A M Bode, A Al-Kali, M R Litzow, B Li, S J Liu
Aberrant DNA methylation mediated by deregulation of DNA methyltransferases (DNMT) is a key hallmark of acute myeloid leukemia (AML), yet efforts to target DNMT deregulation for drug development have lagged. We previously demonstrated that upregulation of fatty acid-binding protein 4 (FABP4) promotes AML aggressiveness through enhanced DNMT1-dependent DNA methylation. Here, we demonstrate that FABP4 upregulation in AML cells occurs through vascular endothelial growth factor (VEGF) signaling, thus elucidating a crucial FABP4-DNMT1 regulatory feedback loop in AML biology...
October 10, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28987858/-effectiveness-of-an-educational-program-for-respiratory-rehabilitation-of-chronic-obstructive-pulmonary-disease-patients-in-primary-care-in-improving-the-quality-of-life-symptoms-and-clinical-risk
#20
Cristina Blánquez Moreno, Cristina Colungo Francia, M Carme Alvira Balada, Belchin Kostov, Luis González-de Paz, Antoni Sisó-Almirall
AIM: To determine the impact of an educational program to improve the management of chronic obstructive pulmonary disease (COPD) that contributes to an increase of the quality of life, exercise capacity, level of dyspnoea, and clinical risk. DESIGN: Intervention study without controls. LOCATION: Primary Healthcare Centre. PARTICIPANTS: 193 patients with COPD were invited, 73 accepted and 55 participated in the educational program...
October 4, 2017: Atencion Primaria
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