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Atsushi Nambu, Jordan Zach, Joyce Schroeder, Gongyoung Jin, Song Soo Kim, Yu-Il Kim, Christina Schnell, Russell Bowler, David A Lynch
PURPOSE: To correlate currently available quantitative CT measurements for airway disease with physiological indices and the body-mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: This study was approved by our institutional review board (IRB number 2778). Written informed consent was obtained from all subjects. The subjects included 188 current and former cigarette smokers from the COPDGene cohort who underwent inspiratory and expiratory CT and also had physiological measurements for the evaluation of airflow limitation, including FEF25-75%, airway resistance (Raw), and specific airway conductance (sGaw)...
November 2016: European Journal of Radiology
Helena Logotheti, Chryssa Pourzitaki, Georgia Tsaousi, Zoi Aidoni, Artemis Vekrakou, Amaniti Ekaterini, Konstantinos Gourgoulianis
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) has been associated with major perioperative morbidities or mortalities, especially in surgical patients receiving general anesthesia. The severity of the COPD and the degree of bronchial hyperreactivity can determine the perioperative anesthetic risk; therefore they have to be assessed by a thorough preoperative evaluation in order to give the rationale on which to decide for optimum anesthetic management. OBJECTIVE: Aim of the study was to assess the predictive applicability of exhaled Nitric Oxide (NO) in smoking surgical population with COPD, on the basis of morbidity and mortality...
October 19, 2016: Nitric Oxide: Biology and Chemistry
Francesca de Blasio, Francesco de Blasio, Giulia Miracco Berlingieri, Andrea Bianco, Marta La Greca, Frits M E Franssen, Luca Scalfi
BACKGROUND: Multifrequency bioelectrical impedance analysis (MF-BIA) is a technique that measures body impedance (Z) at different frequencies (5, 10, 50, 100, and 250 kHz). Body composition may be estimated using empirical equations, which include BIA variables or, alternatively, raw BIA data may provide direct information on water distribution and muscle quality. OBJECTIVES: To compare raw MF-BIA data between COPD patients and controls and to study their relationship with respiratory and functional parameters in COPD patients...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Daniela Graner Schuwartz Tannus-Silva, João Batista Masson-Silva, Lays Silva Ribeiro, Marcus Barreto Conde, Marcelo Fouad Rabahi
BACKGROUND AND OBJECTIVE: COPD, a systemic illness associated with the impairment of different organs, affects patient prognosis and quality of life. The aim of this study was to evaluate the association between right ventricle (RV) function, the BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) index (a multifunctional scale for the assessment of mortality risk), and quality of life in patients with COPD. METHODS: A cross-sectional study was carried out in 107 outpatients presenting with stable COPD who underwent clinical assessment, spirometry, arterial blood gas analyses, a 6-minute walk test, electrocardiography, and echocardiogram and who responded to the Saint George's Respiratory Questionnaire (SGRQ)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Vasileios Andrianopoulos, Bartolome R Celli, Frits M E Franssen, Victor M Pinto-Plata, Peter M A Calverley, Lowie E G W Vanfleteren, Ioannis Vogiatzis, Jørgen Vestbo, Alvar Agusti, Per S Bakke, Stephen I Rennard, William MacNee, Ruth Tal-Singer, Julie C Yates, Emiel F M Wouters, Martijn A Spruit
Exercise-induced oxygen desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics. Data from 2050 COPD patients (age: 63.3 ± 7.1years; FEV1: 48.7 ± 15.7%pred.) were analyzed. The occurrence of EID (SpO2post ≤88%) at the six-minute walking test (6MWT) was investigated in association with emphysema quantified by computed-tomography (QCT), and several clinical characteristics...
October 2016: Respiratory Medicine
Borja G Cosio, Joan B Soriano, Jose Luis López-Campos, Myriam Calle, Juan José Soler, Juan Pablo de-Torres, Jose Maria Marín, Cristina Martínez, Pilar de Lucas, Isabel Mir, Germán Peces-Barba, Nuria Feu-Collado, Ingrid Solanes, Inmaculada Alfageme
RATIONALE: The Spanish guideline for COPD (GesEPOC) recommends COPD treatment according to four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphysema (NE), asthma-COPD overlap syndrome (ACOS), frequent exacerbator phenotype with emphysema (FEE) or frequent exacerbator phenotype with chronic bronchitis (FECB). However, little is known on the distribution and outcomes of the four suggested phenotypes. OBJECTIVE: We aimed to determine the distribution of these COPD phenotypes, and their relation with one-year clinical outcomes...
2016: PloS One
Alexandru Corlateanu, Victor Botnaru, Serghei Covantev, Silvia Dumitru, Nikolaos Siafakas
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity in the elderly population. COPD leads to a reduced health-related quality of life (HRQL), but the factors which contribute to this are not well understood. A better understanding of the factors which determine HRQL should lead to an improved care for such patients. OBJECTIVES: The purpose of this study was to investigate possible age-related differences in HRQL in a population of patients with a similar severity of obstruction...
2016: Respiration; International Review of Thoracic Diseases
Mahsa Mirdamadi, Besharat Rahimi, Enayat Safavi, Hamidreza Abtahi, Soheil Peiman
BACKGROUND: The precise head to head relationships between Cardio-pulmonary exercise testing (CPET) parameters and patients' daily symptoms/activities and the disease social/emotional impact are less well defined. In this study, the correlation of COPD daily symptoms and quality of life [assessed by St. George's Respiratory Questionnaire (SGRQ)] and COPD severity index (BODE-index) with CPET parameters were investigated. METHODS: Symptom-limited CPET was performed in 37 consecutive COPD (GOLD I-III) subjects during non-exacerbation phase...
August 2016: Journal of Thoracic Disease
Maria-Rosa Güell, Pilar Cejudo, Francisco Ortega, M Carmen Puy, Gema Rodríguez-Trigo, José Ignacio Pijoan, Lorea Martinez-Indart, Amaia Gorostiza, Khaled Bdeir, Bartolome Celli, Juan B Galdiz
INTRODUCTION: In COPD, the benefits of Pulmonary Rehabilitation (PR) tend to wane over time. Whether maintenance techniques may help sustain the benefits achieved after completion of the initial PR program remains controversial. OBJECTIVE: To determine whether a long-term (3-years) maintenance program after PR preserves the short-term effects on outcomes in patients with COPD. METHOD: This was a multi-center prospective randomized trial including 143 patients with moderate-severe COPD, with 3 years of PR maintenance following an 8-week outpatient PR program...
September 9, 2016: American Journal of Respiratory and Critical Care Medicine
Khaled Al-Shair, Umme Kolsum, Dave Singh, Jørgen Vestbo
INTRODUCTION: Fatigue is one of the most disabling symptoms in COPD, but little is known about the impact of fatigue on functional disability. We explored the impact of fatigue and fatigue intensity on exercise tolerance after adjusting for other factors using multivariate analysis and compared it to that of dyspnoea. METHODS: A total of 119 patients with mainly moderate-severe stable COPD (38 % women, mean age 66 years) were enrolled. We used the Medical Research Council dyspnoea scores (MRC), Manchester COPD fatigue scale (MCFS) and its three dimensions, Borg scales for fatigue and dyspnoea, six-minute walk distance (6MWD), St George's Respiratory Questionnaire, the BODE index, and the Centre for Epidemiological Study on Depression scale (CES-D), and we measured spirometry, blood gases, systemic inflammatory markers and fat-free mass index (FFMI)...
August 22, 2016: Lung
Larissa A de Castro, Laís Rg Ribeiro, Rafael Mesquita, Débora R de Carvalho, Josiane M Felcar, Myriam F Merli, Karen Bp Fernandes, Rubens A da Silva, Denilson C Teixeira, Martijn A Spruit, Fabio Pitta, Vanessa S Probst
BACKGROUND: Studies have shown that individuals with COPD have impaired body balance, probably caused by the disease's multisystemic manifestations plus age-related decline in balance, potentially increasing the risk of falling and its consequences. However, little is known about the profile of individuals with COPD who present balance impairments, especially related to sex and disease severity stages. The aim of this work was to compare static and functional balance between subjects with COPD and healthy controls and to check possible differences according to sex and degrees of disease severity...
August 2, 2016: Respiratory Care
Olaf Suess, Theodoros Kombos, Frank Bode
Background. Posterior lumbar interbody fusion (PLIF) is a common surgical treatment for degenerative spinal instability, but many surgeons consider obesity a contraindication for elective spinal fusion. The aim of this study was to analyze whether obesity has any influence on hospitalization parameters, change in clinical status, or complications. Methods. In this prospective study, regression analysis was used to analyze the influence of the body mass index (BMI) on operating time, postoperative care, hospitalization time, type of postdischarge care, change in paresis or sensory deficits, pain level, wound complications, cerebrospinal fluid leakage, and implant complications...
2016: International Journal of Chronic Diseases
Asli Gorek Dilektasli, Janos Porszasz, Richard Casaburi, William W Stringer, Surya P Bhatt, Youngju Pak, Harry B Rossiter, George Washko, Peter J Castaldi, Raul San Jose Estepar, James E Hansen
RATIONALE: In chronic obstructive pulmonary disease both smaller and larger airways are affected. Forced expiratory volume in one second (FEV1) mainly reflects large airways obstruction, while the later fraction of forced exhalation reflects reduction in terminal expiratory flow. OBJECTIVE: To evaluate the relationship between spirometric ratios, including the ratio of forced expiratory volume in 3 and 6 seconds (FEV3/FEV6), and small airway measures and gas trapping in quantitative chest computed tomography (CT), and clinical outcomes in the COPDGene cohort...
July 21, 2016: Chest
Amelia Guadalupe-Grau, Susana Aznar-Laín, Asier Mañas, Juan Castellanos, Julián Alcázar, Ignacio Ara, Esmeralda Mata, Rosa Daimiel, Francisco José García-García
To investigate the short and long time effects of concurrent strength and high intensity interval training (HIIT) on octogenarian COPD patients, nine males (age=84.2 ± 2.8 yrs, BMI=29.3 ± 2.3), with low to severe COPD level (2.1 ± 1.5 BODE index), underwent a supervised 9-week strength and HIIT exercise program. Training had a significant (P<0.05) impact on senior fitness test scores (23-45%), 30m walking speed (from 1.29 ± 0.29 to 1.62 ± 0.33 m/s), leg and chest press 1RM (38 and 45% respectively), maximal isometric strength (30-35%), and 6-minute walking test (from 286...
July 12, 2016: Journal of Aging and Physical Activity
Nobuyuki Horita, Vladimir Koblizek, Marek Plutinsky, Barbora Novotna, Karel Hejduk, Takeshi Kaneko
BACKGROUND: The evaluation of chronic obstructive pulmonary disease (COPD) has been shifting from spirometry to focus on the patients' overall health. Despite the existence of many COPD prognostic scales, there remains a large gap for improvement, in particular a scale that incorporates the current focus on overall health. METHODS: We proposed a new prognostic scale (the COPD Prognostic Score) through discussion among the authors based on published studies. Validation was retrospective, using data from the National Emphysema Treatment Trial...
June 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Patrizio Vitulo, Anna Stanziola, Marco Confalonieri, Daniela Libertucci, Tiberio Oggionni, Paola Rottoli, Giuseppe Paciocco, Fabio Tuzzolino, Lavinia Martino, Marta Beretta, Adriana Callari, Andrea Amaducci, Roberto Badagliacca, Roberto Poscia, Federica Meloni, Rosa Metella Refini, Pietro Geri, Sergio Baldi, Stefano Ghio, Michele D'Alto, Paola Argiento, Matteo Sofia, Mara Guardamagna, Beatrice Pezzuto, Carmine Dario Vizza
BACKGROUND: Pulmonary hypertension (PH) is a well-known independent prognostic factor in chronic obstructive pulmonary disease (COPD) and a sufficient criterion for lung transplant candidacy. Limited data are currently available on the hemodynamic and clinical effect of phosphodiesterase 5 inhibitors in patients with severe PH associated with COPD. This study assessed the effect of sildenafil on pulmonary hemodynamics and gas exchange in severe PH associated with COPD. METHODS: After screening, this multicenter, randomized, placebo-controlled double-blind trial randomized patients to receive 20 mg sildenafil or placebo 3 times a day (ratio 2:1) for 16 weeks...
May 7, 2016: Journal of Heart and Lung Transplantation
F Rodrigues, A L Papoila, D Ligeiro, M J M Gomes, H Trindade
Systemic inflammation has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD) systemic effects. However, most COPD patients do not suffer from persistent systemic inflammation even after exacerbations and exercise and scientific evidence has provided conflicting results. Our aim is to evaluate inflammatory gene expression at rest and at 1 and 24h after strenuous exercise in COPD patients and study the patient variables associated with inflammatory expression. A cross-sectional study was conducted in COPD patients who were recruited on entry to a pulmonary rehabilitation (PR) program...
June 16, 2016: Revista Portuguesa de Pneumologia
J Y Yoo, Y S Kim, S S Kim, H K Lee, C G Park, E G Oh, Y M Oh
BACKGROUND: Health-related quality of life (HR-QoL) is an important issue in patients with chronic obstructive pulmonary disease (COPD), as in other chronic illness groups. However, there is limited information on longitudinal changes in HR-QoL over time with the illness trajectory model. OBJECTIVE: To identify different patterns of HR-QoL changes in longitudinal data, and reveal potential predictors affecting these trajectories. METHODS: Subjects with COPD (n = 249) were drawn from the Korean Obstructive Lung Disease cohort, which was conducted from 2005 to 2012...
June 2016: International Journal of Tuberculosis and Lung Disease
José Cerón Navarro, Karol de Aguiar Quevedo, Carlos Jordá Aragón, Juan C Peñalver Cuesta, Nuria Mancheño Franch, Francisco Vera Sempere, José Padilla Alarcón
INTRODUCTION: Lung transplantation (LT) has been considered an alternative therapeutic approach in terminal patients. However, this process in COPD is not controversy-free. This paper aimed to analyze 30-day mortality (PM) patterns and their risk factors in COPD patients undergoing LT. PATIENTS AND METHOD: A retrospective cohort with 107 COPD patients, transplanted at the University La Fe Valencia, Spain, treated from January 1991 to December 2008. Demographics values, degree of dyspnoea, diagnosis, BODE index, single versus bilateral LT, cardio-pulmonary bypass, donor age, steroid dependence, presence of bronchiectasis, retrograde perfusion, transfusion of blood products, and PaO2/FiO2 were analyzed...
June 17, 2016: Medicina Clínica
Hoi Nam Tse, Cee Zhung Steven Tseng, King Ying Wong, Lai Yun Ng, Tin Lok Lai, Kwok Sang Yee
INTRODUCTION: Depression is associated with a poorer quality of life and higher rate of COPD exacerbations and mortality. However, with multiple confounding factors, 'independent' risk factor for depression among COPD patients remains ambiguous. Our study aims to identify independent risk factors for depression by specifically evaluating for any independent relationship between frequent exacerbations and various domains of the BODE index on depression. METHODS: This study is a cross-sectional study, conducted in Hong Kong SAR...
August 2016: Lung
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