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https://www.readbyqxmd.com/read/29932922/pdgf-family-function-and-prognostic-value-in-tumor-biology
#1
Michael Bartoschek, Kristian Pietras
The development and progression of a tumor depends on the close interaction of malignant cells and the supportive and suppressive tumor microenvironment. Paracrine signaling enables tumor cells to shape the surrounding tissue in order to decrease recognition by the immune system, attract blood vessels to fuel growth, change metabolic programs and induce wound healing programs. In this study, we investigate the role of the platelet-derived growth factor (PDGF) family members PDGFA, PDGFB, PDGFC and PDGFD and their cognate tyrosine kinase receptors PDGFRA and PDGFRB, using publicly available data from The Cancer Genome Atlas and the Human Protein Atlas...
June 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29932155/a-quantitative-proteomics-view-on-the-function-of-qfhb1-a-major-qtl-for-fusarium-head-blight-resistance-in-wheat
#2
Moustafa Eldakak, Aayudh Das, Yongbin Zhuang, Jai S Rohila, Karl Glover, Yang Yen
Fusarium head blight (FHB) is a highly detrimental disease of wheat. A quantitative trait locus for FHB resistance, Qfhb1 , is the most utilized source of resistance in wheat-breeding programs, but very little is known about its resistance mechanism. In this study, we elucidated a prospective FHB resistance mechanism by investigating the proteomic signatures of Qfhb1 in a pair of contrasting wheat near-isogenic lines (NIL) after 24 h of inoculation of wheat florets by Fusarium graminearum . Statistical comparisons of the abundances of protein spots on the 2D-DIGE gels of contrasting NILs (fhb1+ NIL = Qfhb1 present; fhb1- NIL = Qfhb1 absent) enabled us to select 80 high-ranking differentially accumulated protein (DAP) spots...
June 22, 2018: Pathogens
https://www.readbyqxmd.com/read/29931419/genetic-variants-of-major-genes-contributing-to-phosphate-and-calcium-homeostasis-and-their-association-with-serum-parameters-in-pigs
#3
Franziska Just, Henry Reyer, Eduard Muráni, Siriluck Ponsuksili, Michael Oster, Klaus Wimmers
Calcium and phosphorus are irreplaceable components of life. Tracking the fate of calcium and phosphorus in organisms deserves high attention due to their relevance in bone metabolism and subsequently animal health. Indeed, bone serves as reservoir for calcium and phosphorus, whose formation and resorption follow specific molecular routes including hormones, receptors, and transcription factors. The objective of the study was to analyze the genetic variation of major components driving mineral utilization such as calcitonin receptor, calcium sensing receptor, fibroblast growth factor 23 (FGF23), parathyroid hormone receptor, osteopontin, stanniocalcin 1, RAF-type zinc finger domain containing 1 (TRAFD1), and vitamin D receptor...
June 22, 2018: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29928337/dysregulated-genes-targeted-by-micrornas-and-metabolic-pathways-in-bladder-cancer-revealed-by-bioinformatics-methods
#4
Lu Zhang, Cuihua Feng, Yamin Zhou, Qiong Zhou
The present study aimed to identify bladder cancer-associated microRNAs (miRNAs) and target genes, and further analyze the potential molecular mechanisms involved in bladder cancer. The mRNA and miRNA expression profiling dataset GSE40355 was downloaded from the Gene Expression Omnibus database. The Limma package in R was used to identify differential expression levels. The Human microRNA Disease Database was used to identify bladder cancer-associated miRNAs and Target prediction programs were used to screen for miRNA target genes...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29926362/polymorphisms-within-the-prolactin-and-growth-hormone-insulin-like-growth-factor-1-functional-pathways-associated-with-fertility-traits-in-holstein-cows-raised-in-a-hot-humid-climate
#5
Jose C Leyva-Corona, Javier R Reyna-Granados, Ricardo Zamorano-Algandar, Miguel A Sanchez-Castro, Milton G Thomas, R Mark Enns, Scott E Speidel, Juan F Medrano, Gonzalo Rincon, Pablo Luna-Nevarez
Prolactin (PRL), growth hormone (GH), and insulin-like growth factor-1 (IGF-1) are in hormone-response pathways involved in energy metabolism during thermoregulation processes in cattle. Objective herein was to study the association between single nucleotide polymorphisms (SNP) within genes of the PRL and GH/IGF-1 pathways with fertility traits such as services per conception (SPC) and days open (DO) in Holstein cattle lactating under a hot-humid climate. Ambient temperature and relative humidity were used to calculate the temperature-humidity index (THI) which revealed that the cows were exposed to heat stress conditions from June to November of 2012 in southern Sonora, Mexico...
June 20, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29925936/does-underestimated-penile-size-impact-erectile-function-in-healthy-men
#6
Brunno Cf Sanches, Walker W Laranja, João Cc Alonso, Ronald F Rejowski, Fabiano A Simões, Leonardo O Reis
The aim of this study is to assess the impact of objective (stretched) and subjective penile size in the erectile function in a urological check-up program on a cross-sectional study including 689 men aged 35-70 years. IIEF-5 questionnaire, physical examination (penile length, prostate volume, blood pressure, body mass index-BMI), metabolic syndrome (MS), comorbidities, habits (sexual intercourse frequency, physical activity, alcohol, and tobacco use), level of education, serum glucose, total testosterone, estradiol, PSA, lipid profile, and self-perceptions (ejaculation time and subjective penile size) were examined in multivariate models using logistic and linear regressions...
June 21, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29925515/change-in-inflammatory-biomarkers-and-adipose-tissue-in-brca1-2-breast-cancer-survivors-following-a-year-long-lifestyle-modification-program
#7
Kathleen M Sturgeon, Wayne Y Foo, Mariane L Heroux, Kathryn Schmitz
Breast cancer survivors who carry a genetic mutation for one of the BRCA genes often undergo surgically-induced menopause a decade or more before the usual age of natural menopause. These women are at elevated risk for multiple negative health outcomes, including metabolic diseases, heart disease, and cancer recurrence. Effects of a 12-month commercially available web-based lifestyle program (Precision Nutrition) were tested on body composition and markers of inflammation in a randomized controlled trial. Participants (N=35) were BRCA1/2+, breast cancer survivors, and had completed surgically-induced menopause at age <45 years...
June 20, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29925339/maternal-overweight-is-not-an-independent-risk-factor-for-increased-birth-weight-leptin-and-insulin-in-newborns-of-gestational-diabetic-women-observations-from-the-prospective-each-cohort-study
#8
Raffael Ott, Jens H Stupin, Andrea Loui, Elisabeth Eilers, Kerstin Melchior, Rebecca C Rancourt, Karen Schellong, Thomas Ziska, Joachim W Dudenhausen, Wolfgang Henrich, Andreas Plagemann
BACKGROUND: Both gestational diabetes mellitus (GDM) as well as overweight/obesity during pregnancy are risk factors for detrimental anthropometric and hormonal neonatal outcomes, identified to 'program' adverse health predispositions later on. While overweight/obesity are major determinants of GDM, independent effects on critical birth outcomes remain unclear. Thus, the aim of the present study was to evaluate, in women with GDM, the relative/independent impact of overweight/obesity vs...
June 20, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29924631/effects-of-postweaning-calorie-restriction-on-accelerated-growth-and-adiponectin-in-nutritionally-programmed-microswine-offspring
#9
Elizabeth A DuPriest, Baoyu Lin, Philipp Kupfer, Kaiu Sekiguchi, Amruta Bhusari, Alexandra Quackenbush, Almir Celebic, Terry K Morgan, Jonathan Q Purnell, Susan Pound Bagby
Poor prenatal development followed by rapid childhood growth conveys greater cardiometabolic risk in later life. Microswine offspring exposed to perinatal maternal protein restriction (MPR; "low protein offspring", LPO) grow poorly in late-fetal/neonatal stages. After weaning to ad libitum (AL) diet, LPO-AL exhibit accelerated growth and fat deposition rates with low adiponectin mRNA despite low-normal body fat and small intra-abdominal adipocytes. We examined effects of caloric restriction (CR) on growth and metabolic status in LPO and normal protein offspring (NPO) randomized to AL or CR diets from weaning...
June 20, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29924460/cc002-unc-females-are-mouse-models-of-exercise-induced-paradoxical-fat-response
#10
Rachel C McMullan, Martin T Ferris, Timothy A Bell, Vineet D Menachery, Ralph S Baric, Kunjie Hua, Daniel Pomp, Abbie E Smith-Ryan, Fernando Pardo-Manuel de Villena
Exercise results in beneficial health outcomes and protects against a variety of chronic diseases. However, U.S. exercise guidelines recommend identical exercise programs for everyone, despite individual variation in responses to these programs, including paradoxical fat gain. Experimental models of exercise-induced paradoxical outcomes may enable the dissection of underlying physiological mechanisms as well as the evaluation of potential interventions. Whereas several studies have identified individual mice exhibiting paradoxical fat gain following exercise, no systematic effort has been conducted to identify and characterize models of paradoxical response...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29922517/transcriptional-regulation-of-metabolism-in-disease-from-transcription-factors-to-epigenetics
#11
Liam J Hawkins, Rasha Al-Attar, Kenneth B Storey
Every cell in an individual has largely the same genomic sequence and yet cells in different tissues can present widely different phenotypes. This variation arises because each cell expresses a specific subset of genomic instructions. Control over which instructions, or genes, are expressed is largely controlled by transcriptional regulatory pathways. Each cell must assimilate a huge amount of environmental input, and thus it is of no surprise that transcription is regulated by many intertwining mechanisms...
2018: PeerJ
https://www.readbyqxmd.com/read/29922301/novel-fungal-pathogenicity-and-leaf-defense-strategies-are-revealed-by-simultaneous-transcriptome-analysis-of-colletotrichum-fructicola-and-strawberry-infected-by-this-fungus
#12
Liqing Zhang, Xin Huang, Chengyong He, Qing-Yu Zhang, Xiaohua Zou, Ke Duan, Qinghua Gao
Colletotrichum fructicola , which is part of the C. gloeosporioides species complex, can cause anthracnose diseases in strawberries worldwide. However, the molecular interactions between C. fructicola and strawberry are largely unknown. A deep RNA-sequencing approach was applied to gain insights into the pathogenicity mechanisms of C. fructicola and the defense response of strawberry plants at different stages of infection. The transcriptome data showed stage-specific transcription accompanied by a step-by-step strawberry defense response and the evasion of this defense system by fungus...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29922156/ibogaine-detoxification-transitions-opioid-and-cocaine-abusers-between-dependence-and-abstinence-clinical-observations-and-treatment-outcomes
#13
Deborah C Mash, Linda Duque, Bryan Page, Kathleen Allen-Ferdinand
Ibogaine may be effective for transitioning opioid and cocaine dependent individuals to sobriety. American and European self-help groups provided public testimonials that ibogaine alleviated drug craving and opioid withdrawal symptoms after only a single dose administration. Preclinical studies in animal models of addiction have provided proof-of-concept evidence in support of these claims. However, the purported therapeutic benefits of ibogaine are based on anecdotal reports from a small series of case reports that used retrospective recruitment procedures...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29921717/dysregulation-of-nad-metabolism-induces-a-schwann-cell-dedifferentiation-program
#14
Yo Sasaki, Amber R Hackett, Sungsu Kim, Amy Strickland, Jeffrey Milbrandt
The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the importance of SC metabolism in nerve function and in peripheral neuropathies associated with metabolic disorders. Nicotinamide adenine dinucleotide (NAD+ ) is a crucial molecule in the regulation of cellular metabolism and redox homeostasis. Here, we investigated the roles of NAD+ metabolism in SC functions in vivo by mutating NAMPT, the rate-limiting enzyme of NAD+ biosynthesis, specifically in SCs...
June 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29921290/causes-of-mortality-and-morbidity-in-free-ranging-mustelids-in-switzerland-necropsy-data-from-over-50-years-of-general-health-surveillance
#15
E Akdesir, F C Origgi, J Wimmershoff, J Frey, C F Frey, M-P Ryser-Degiorgis
BACKGROUND: Although mustelids occur worldwide and include a wide range of species, little is known about the diseases affecting them. Mustelids have regularly been submitted for post mortem investigation in the framework of the program for general wildlife health surveillance in Switzerland, which has been in place for nearly 60 years. We performed a retrospective analysis of the necropsy reports on mustelids submitted to the diagnostic service of the University of Bern. The aims of this study were to present an overview of the causes of mortality and morbidity observed in these carnivores, to assess differences among species, to assess changes in disease detection over the study period, and to describe the pathology of selected diseases...
June 19, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29921210/off-label-use-of-drugs-and-adverse-drug-reactions-in-pediatric-units-a-prospective-multicenter-study
#16
Andrea D Pratico, Laura Longo, Silvana Mansueto, Lucia Gozzo, Ignazio Barberi, Venera Tiralongo, Vincenzo Salvo, Raffaele Falsaperla, Giovanna Vitaliti, Mario La Rosa, Antonio Rotondo, Nicoletta Avola, Debora Sgarlata, Annalisa Damiano, Massimo Tirantello, Gaspare Anzelmo, Domenico Cipolla, Angelo Rizzo, Antonio Russo, Martino Ruggieri, Salvatore Salomone, Filippo Drago
BACKGROUND: Given the growing use of off-label in pediatric practice, there is a growing interest on pharmacovigilance programs monitoring the occurrence of adverse drug reactions related to off-label drug prescription in childhood. PATIENTS AND METHODS: The results of a one-year program of pharmacovigilance issued in the Sicilian Region, Italy, are herein presented. The study involved 6 pediatric and neonatal centres and prospectively reviewed the prescriptions of 5,060 patients, who were stratified for age (newborn, infant, children, adolescents)...
June 19, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29915744/prevalence-of-metabolic-syndrome-crossing-40-in-northern-india-time-to-act-fast-before-it-runs-out-of-proportions
#17
Yasmee Khan, Arati Lalchandani, Ajesh Chandra Gupta, Sagar Khadanga, Sanjeev Kumar
Background: Metabolic syndrome (MetS) is a constellation of high blood pressure, hyperglycemia, obesity, and dyslipidemia. Its presence makes the patient more prone for cardiovascular events. Its prevalence has been documented as 11%-41%. The present study was undertaken to find out the demographic profile of the MetS in Kanpur region of northern India. Materials and Methods: This is a hospital based, cross-sectional study with adequate sample size. Results: Out of the randomly selected 420 patients (232 males and 188 females), 172 cases (61 males and 111 females) were found to have MeTS adopting the National Cholesterol Education Program Adult Treatment Panel III criteria...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915523/the-prevalence-of-obesity-and-metabolic-syndrome-in-the-korean-military-compared-with-the-general-population
#18
Jung Hwan Lee, Da Hea Seo, Min Jung Nam, Geon Hui Lee, Dong Hee Yang, Min Joo Lee, Ung-Rim Choi, Seongbin Hong
Background: Obesity and related metabolic disorders are growing health challenges worldwide and individuals at military service are not exceptions. The purpose of this study was to examine the prevalence of obesity and metabolic syndrome (MS) in the Korean military and to compare with the general population. Methods: This was a cross-sectional study of 4,803 young military participants who underwent a corporal health-screening program between October 2013 and October 2014...
June 18, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29914755/transition-from-pediatric-to-adult-care-in-adolescents-with-hereditary-metabolic-diseases-specific-guidelines-from-the-french-network-for-rare-inherited-metabolic-diseases-g2m
#19
B Chabrol, P Jacquin, L Francois, P Broué, D Dobbelaere, C Douillard, S Dubois, F Feillet, A Perrier, A Fouilhoux, F Labarthe, D Lamireau, K Mazodier, F Maillot, F Mochel, M Schiff, N Belmatoug
Inherited metabolic diseases (IMD) form a heterogeneous group of genetic disorders that surface primarily during childhood and result in significant morbidity and mortality. A prevalence of 1 in 2500-5000 live births is often reported. The transfer of adolescents from pediatric care to adult health facilities is often difficult for patients and their families and can lead to a breakdown in medical follow-up and therefore serious complications. Existing recommendations for the successful transition of patients with chronic disorders do not specifically address patients with IMDs associated with dietary treatment...
June 15, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29914471/how-accurate-is-automated-gap-filling-of-metabolic-models
#20
Peter D Karp, Daniel Weaver, Mario Latendresse
BACKGROUND: Reaction gap filling is a computational technique for proposing the addition of reactions to genome-scale metabolic models to permit those models to run correctly. Gap filling completes what are otherwise incomplete models that lack fully connected metabolic networks. The models are incomplete because they are derived from annotated genomes in which not all enzymes have been identified. Here we compare the results of applying an automated likelihood-based gap filler within the Pathway Tools software with the results of manually gap filling the same metabolic model...
June 19, 2018: BMC Systems Biology
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