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https://www.readbyqxmd.com/read/29457842/long-term-outcomes-of-patients-undergoing-simultaneous-liver-transplantation-and-sleeve-gastrectomy
#1
Daniel Zamora-Valdes, Kymberly D Watt, Todd A Kellogg, John J Poterucha, Sara R Di Cecco, Nicki M Francisco-Ziller, Timucin Taner, Charles B Rosen, Julie K Heimbach
BACKGROUND: Obesity is increasingly common before and after liver transplantation (LT), yet optimal management remains unclear. AIM: To analyze the long term outcomes for obese patients undergoing LT including a non-invasive weight loss program and combined LT and sleeve gastrectomy (SG). METHODS: Since 2006, all patients referred for LT with a body mass index (BMI) ≥35 kg/m2 were enrolled. Patients who achieved weight loss (BMI<35) underwent LT alone, and those who did not underwent simultaneous LT+SG...
February 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29455847/the-fate-choice-between-effector-and-memory-t-cell-lineages-asymmetry-signal-integration-and-feedback-to-create-bistability
#2
Ronald A Backer, Pleun Hombrink, Christina Helbig, Derk Amsen
CD8+ T cells clear primary infections with intracellular pathogens and provide long-term immunity against reinfection. Two different types of CD8+ T cells are responsible for these functions: short-lived effector T cells and memory T cells. The cellular relationship between these two types of CD8+ T cells has been subject to much investigation. Both cell types can derive from a single naïve CD8+ T cell precursor. Their generation requires a fate choice early during a T cell response. As a result, two populations of T cells emerge...
2018: Advances in Immunology
https://www.readbyqxmd.com/read/29455688/early-life-nutritional-status-and-metabolic-syndrome-gender-specific-associations-from-a-cross-sectional-analysis-of-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#3
Bruna Lucas Briskiewicz, Sandhi Maria Barreto, Joana Ferreira do Amaral, Maria de Fátima Haueisen Sander Diniz, Maria Del Carmen Bisi Molina, Sheila Maria Alvim Matos, Letícia de Oliveira Cardoso, Gustavo Velasquez-Melendez, Maria Inês Schmidt, Luana Giatti
OBJECTIVE: In the present study we investigated gender-specific associations of low birth weight (LBW) and shorter relative leg length with metabolic syndrome (MetS) after adjusting for sociodemographic characteristics and health-related behaviours. We also investigated whether these associations are independent of age at menarche and BMI at 20 years old. DESIGN: Cross-sectional analysis. SUBJECTS: Baseline data from 12 602 participants (35-74 years) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), 2008-2010...
February 19, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29454332/do-pregnancies-reduce-iron-overload-in-hfe-hemochromatosis-women-results-from-an-observational-prospective-study
#4
Virginie Scotet, Philippe Saliou, Marianne Uguen, Carine L'Hostis, Marie-Christine Merour, Céline Triponey, Brigitte Chanu, Jean-Baptiste Nousbaum, Gerald Le Gac, Claude Ferec
BACKGROUND: HFE hemochromatosis is an inborn error of iron metabolism linked to a defect in the regulation of hepcidin synthesis. This autosomal recessive disease typically manifests later in women than men. Although it is commonly stated that pregnancy is, with menses, one of the factors that offsets iron accumulation in women, no epidemiological study has yet supported this hypothesis. The aim of our study was to evaluate the influence of pregnancy on expression of the predominant HFE p...
February 17, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29453589/validity-of-triglyceride-glucose-index-as-an-indicator-for-metabolic-syndrome-in-children-and-adolescents-the-caspian-v-study
#5
Pooneh Angoorani, Ramin Heshmat, Hanieh-Sadat Ejtahed, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Tahereh Aminaee, Azam Goodarzi, Mostafa Qorbani, Roya Kelishadi
PURPOSE: The purpose of this study was to determine the cut-off values of triglycerides and glucose (TyG) index as one of the indirect indices for metabolic syndrome (MetS) in a pediatric population. METHODS: This national study was conducted in 2015 on 14400 students, aged 7-18 years. They were selected by random cluster sampling from 30 provinces of our country during the fifth survey of a national school-based surveillance program. MetS was defined based on the Adult Treatment Panel III (ATP III) criteria modified for the pediatric age group...
February 16, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29452626/translation-of-an-evidence-based-therapeutic-exercise-program-for-patients-with-peripheral-artery-disease
#6
Dereck L Salisbury, Mary O Whipple, Marsha Burt, Rebecca J L Brown, Alan Hirsch, Christopher Foley, Diane Treat-Jacobson
The purpose of this study was to implement and evaluate quality outcomes including referral, enrollment, and completion rates of a new peripheral artery disease (PAD)-specific supervised exercise therapy (SET) program within a preexisting clinical exercise wellness program and to evaluate the clinical effectiveness and patient-centered outcomes derived from 12 weeks of PAD-specific SET. Recruited participants completed an individualized, minimally supervised, PAD-specific SET program based on the AHA-ACC guidelines...
March 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29449858/exogenous-hydrogen-peroxide-contributes-to-heme-oxygenase-1-delaying-programmed-cell-death-in-isolated-aleurone-layers-of-rice-subjected-to-drought-stress-in-a-cgmp-dependent-manner
#7
Guanghui Wang, Yu Xiao, Xiaojiang Deng, Heting Zhang, Tingge Li, Huiping Chen
Hydrogen peroxide (H 2 O 2 ) is a reactive oxygen species (ROS) that plays a dual role in plant cells. Here, we discovered that drought (20% polyethylene glycol-6000, PEG)-triggered decreases of HO-1 transcript expression and HO activity. However, exogenous H 2 O 2 contributed toward the increase in HO-1 gene expression and activity of the enzyme under drought stress. Meanwhile, the HO-1 inducer hematin could mimic the effects of the H 2 O 2 scavengers ascorbic acid (AsA) and dimethylthiourea (DMTU) and the H 2 O 2 synthesis inhibitor diphenyleneiodonium (DPI) for scavenging or diminishing drought-induced endogenous H 2 O 2 ...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29447345/the-biocyc-collection-of-microbial-genomes-and-metabolic-pathways
#8
Peter D Karp, Richard Billington, Ron Caspi, Carol A Fulcher, Mario Latendresse, Anamika Kothari, Ingrid M Keseler, Markus Krummenacker, Peter E Midford, Quang Ong, Wai Kit Ong, Suzanne M Paley, Pallavi Subhraveti
BioCyc.org is a microbial genome Web portal that combines thousands of genomes with additional information inferred by computer programs, imported from other databases and curated from the biomedical literature by biologist curators. BioCyc also provides an extensive range of query tools, visualization services and analysis software. Recent advances in BioCyc include an expansion in the content of BioCyc in terms of both the number of genomes and the types of information available for each genome; an expansion in the amount of curated content within BioCyc; and new developments in the BioCyc software tools including redesigned gene/protein pages and metabolite pages; new search tools; a new sequence-alignment tool; a new tool for visualizing groups of related metabolic pathways; and a facility called SmartTables, which enables biologists to perform analyses that previously would have required a programmer's assistance...
August 17, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29446245/differential-metabolic-effects-of-constant-moderate-versus-high-intensity-interval-training-in-high-fat-fed-mice-possible-role-of-muscle-adiponectin
#9
Sergio F Martinez-Huenchullan, Babu Raja Maharjan, Paul F Williams, Charmaine S Tam, Susan V Mclennan, Stephen M Twigg
Exercise regimens may have differing effects in the presence of obesity. In addition to being fat derived, adiponectin has recently been described as a myokine that regulates insulin sensitivity, which may link to exercise-related metabolic benefits in obesity. Whether skeletal muscle adiponectin varies in different exercise modalities is unclear. This study investigated the comparative effects of 10 weeks of endurance constant-moderate intensity exercise (END) with high intensity interval training (HIIT), on metabolic outcomes, including muscle adiponectin in a mouse model of diet-induced obesity...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29445452/exploiting-immune-cell-metabolic-machinery-for-functional-hiv-cure-and-the-prevention-of-inflammaging
#10
REVIEW
Clovis S Palmer, Riya Palchaudhuri, Hassan Albargy, Mohamed Abdel-Mohsen, Suzanne M Crowe
An emerging paradigm in immunology suggests that metabolic reprogramming and immune cell activation and functions are intricately linked. Viral infections, such as HIV infection, as well as cancer force immune cells to undergo major metabolic challenges. Cells must divert energy resources in order to mount an effective immune response. However, the fact that immune cells adopt specific metabolic programs to provide host defense against intracellular pathogens and how this metabolic shift impacts immune cell functions and the natural course of diseases have only recently been appreciated...
2018: F1000Research
https://www.readbyqxmd.com/read/29445363/-helicobacter-pylori-infection-is-not-associated-with-non-alcoholic-fatty-liver-disease-a-cross-sectional-study-in-china
#11
Nengguang Fan, Liang Peng, Zhenhua Xia, Lijuan Zhang, Yufan Wang, Yongde Peng
Background and Aim: Helicobacter pylori infection has been reported to promote the development of a variety of extra-digestive manifestations, including type 2 diabetes, cardiovascular and liver diseases. Recently, the association between H. pylori infection and non-alcoholic fatty liver disease (NAFLD) was also proposed. However, evidence from different studies was controversial. We therefore performed this study to investigate the relationship between them in a large population of apparently healthy subjects in China...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29444663/gender-related-differences-in-cardiometabolic-risk-factors-and-lifestyle-behaviors-in-treatment-seeking-adolescents-with-severe-obesity
#12
Lisa Ha Barstad, Pétur B Júlíusson, Line Kristin Johnson, Jens Kristoffer Hertel, Samira Lekhal, Jøran Hjelmesæth
BACKGROUND: Obesity during adolescence is associated with cardiovascular mortality in adulthood. The adverse obesity-related cardiometabolic risk profile is already observed in adolescence. We aimed to examine possible gender differences in cardiometabolic risk factors and lifestyle behaviors among adolescents with severe obesity, hypothesizing that boys would have both a higher prevalence of the metabolic syndrome as well as less healthy lifestyle behaviors than girls. METHODS: Cross-sectional study of treatment-seeking adolescents with severe obesity who attended the Morbid Obesity Centre at Vestfold Hospital Trust and who were consecutively enrolled in the Vestfold Register of Obese Children between September 2009 and September 2015...
February 14, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29444634/evaluation-of-reaction-gap-filling-accuracy-by-randomization
#13
Mario Latendresse, Peter D Karp
BACKGROUND: Completion of genome-scale flux-balance models using computational reaction gap-filling is a widely used approach, but its accuracy is not well known. RESULTS: We report on computational experiments of reaction gap filling in which we generated degraded versions of the EcoCyc-20.0-GEM model by randomly removing flux-carrying reactions from a growing model. We gap-filled the degraded models and compared the resulting gap-filled models with the original model...
February 14, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29444484/application-of-a-new-targeted-low-density-microarray-and-conventional-biomarkers-to-evaluate-the-health-status-of-marine-mussels-a-field-study-in-sardinian-coast-italy
#14
Susanna Sforzini, Caterina Oliveri, Andrea Orrù, Giannina Chessa, Beniamina Pacchioni, Caterina Millino, Awadhesh N Jha, Aldo Viarengo, Mohamed Banni
In the present study, we investigated the health status of marine mussels (Mytilus galloprovincialis) caged and deployed at three different sites on the Sardinian coastline characterized by different levels of contamination: Fornelli (F, the reference site), Cala Real (CR), and Porto Torres (PT). A new low density oligonucleotide microarray was used to investigate global gene expression in the digestive gland of mussels. Target genes were selected to cover most of the biological processes involved in the stress response in bivalve mollusks (e...
February 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29444133/a-long-term-mechanistic-computational-model-of-physiological-factors-driving-the-onset-of-type-2-diabetes-in-an-individual
#15
Joydeep Sarkar, Gaurav Dwivedi, Qian Chen, Iris E Sheu, Mark Paich, Colleen M Chelini, Paul M D'Alessandro, Samuel P Burns
A computational model of the physiological mechanisms driving an individual's health towards onset of type 2 diabetes (T2D) is described, calibrated and validated using data from the Diabetes Prevention Program (DPP). The objective of this model is to quantify the factors that can be used for prevention of T2D. The model is energy and mass balanced and continuously simulates trajectories of variables including body weight components, fasting plasma glucose, insulin, and glycosylated hemoglobin among others on the time-scale of years...
2018: PloS One
https://www.readbyqxmd.com/read/29444097/the-effects-of-intensified-training-on-resting-metabolic-rate-rmr-body-composition-and-performance-in-trained-cyclists
#16
Amy L Woods, Anthony J Rice, Laura A Garvican-Lewis, Alice M Wallett, Bronwen Lundy, Margot A Rogers, Marijke Welvaert, Shona Halson, Andrew McKune, Kevin G Thompson
BACKGROUND: Recent research has demonstrated decreases in resting metabolic rate (RMR), body composition and performance following a period of intensified training in elite athletes, however the underlying mechanisms of change remain unclear. Therefore, the aim of the present study was to investigate how an intensified training period, designed to elicit overreaching, affects RMR, body composition, and performance in trained endurance athletes, and to elucidate underlying mechanisms. METHOD: Thirteen (n = 13) trained male cyclists completed a six-week training program consisting of a "Baseline" week (100% of regular training load), a "Build" week (~120% of Baseline load), two "Loading" weeks (~140, 150% of Baseline load, respectively) and two "Recovery" weeks (~80% of Baseline load)...
2018: PloS One
https://www.readbyqxmd.com/read/29443739/effects-of-exercise-on-secretion-transport-inflammation-and-quality-of-life-in-patients-with-noncystic-fibrosis-bronchiectasis-protocol-for-a-randomized-controlled-trial
#17
Daniele Oliveira Dos Santos, Hugo Celso Dutra de Souza, José Antônio Baddini-Martinez, Ercy Mara Cipulo Ramos, Ada Clarice Gastaldi
BACKGROUND: Bronchiectasis is characterized by pathological and irreversible bronchial dilatation caused by the inefficient mucus and microorganism clearance and progression of inflammatory processes. The most frequent characteristic is the increase in bronchial mucus production resulting in slower transport and damage to the mucociliary transport. AIMS: To evaluate the effects of exercise on mucus transport, inflammation, and resistance of the respiratory and autonomic nervous systems and subsequent effects on quality of life in patients with bronchiectasis who are enrolled in a pulmonary rehabilitation program...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29441183/association-of-lifestyle-risk-factors-with-metabolic-syndrome-components-a-cross-sectional-study-in-eastern-india
#18
Pragya Verma, Ratan K Srivastava, Dharmendra Jain
Background: Approximately 20%-25% of the world adult population and nearly 30% of Indians have metabolic syndrome disorder. Our objective was designed to find out the association between important nutrients and potential lifestyle risk factors such as diet, physical inactivity, and smoking and alcohol consumption with the number of metabolic syndrome components. Methods: This was a cross-sectional study. A total of 205 patients of metabolic syndrome were enrolled for this study...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29439515/report-of-the-signal-transduction-society-meeting-2017-metabolism-in-health-and-disease
#19
Bastian Schirmer, Klaudia Giehl, Katharina F Kubatzky
The annual "Joint Meeting Signal Transduction-Receptors, Mediators and Genes" of the Signal Transduction Society (STS) aims to be an interdisciplinary forum for researchers who share a common interest in deciphering signal transduction pathways in normal or transformed cells, in health and disease, in humans and animal models, or in plants or bacteria. The special focus of the 21st annual Joint Meeting, which took place from 8-10 November 2017 in Weimar, was the topic "Metabolism in Health and Disease" and covered multiple aspects of this highly exciting and fast developing research field...
February 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29439389/early-life-exposure-to-non-nutritive-sweeteners-and-the-developmental-origins-of-childhood-obesity-global-evidence-from-human-and-rodent-studies
#20
REVIEW
Alyssa J Archibald, Vernon W Dolinsky, Meghan B Azad
Non-nutritive sweeteners (NNS) are increasingly consumed by children and pregnant women around the world, yet their long-term health impact is unclear. Here, we review an emerging body of evidence suggesting that early-life exposure to NNS may adversely affect body composition and cardio-metabolic health. Some observational studies suggest that children consuming NNS are at increased risk for obesity-related outcomes; however, others find no association or provide evidence of confounding. Fewer studies have examined prenatal NNS exposure, with mixed results from different analytical approaches...
February 10, 2018: Nutrients
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