Jian Tao, Saige Yin, Yongli Song, Lin Zeng, Shanshan Li, Naixin Liu, Huiling Sun, Zhe Fu, Yinglei Wang, Yilin Li, Yixiang Liu, Jun Sun, Ying Wang, Xinwang Yang
Ischemic stroke is a severe threat to human health due to its high recurrence, mortality, and disability rates. As such, how to prevent and treat ischemic stroke effectively has become a research hotspot in recent years. Here, we identified a novel peptide, named HsTx2 (AGKKERAGSRRTKIVMLKCIREHGH, 2 861.855 Da), derived from the scorpion Heterometrus spinifer, which showed obvious anti-apoplectic effects in rats with ischemic stroke. Results further demonstrated that HsTx2 significantly reduced formation of infarct area and improved behavioral abnormalities in ischemic stroke rats...
November 25, 2020: Biochemical and Biophysical Research Communications