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https://www.readbyqxmd.com/read/28817647/caprine-brucellosis-a-historically-neglected-disease-with-significant-impact-on-public-health
#1
REVIEW
Carlos A Rossetti, Angela M Arenas-Gamboa, Estefanía Maurizio
Caprine brucellosis is a chronic infectious disease caused by the gram-negative cocci-bacillus Brucella melitensis. Middle- to late-term abortion, stillbirths, and the delivery of weak offspring are the characteristic clinical signs of the disease that is associated with an extensive negative impact in a flock's productivity. B. melitensis is also the most virulent Brucella species for humans, responsible for a severely debilitating and disabling illness that results in high morbidity with intermittent fever, chills, sweats, weakness, myalgia, abortion, osteoarticular complications, endocarditis, depression, anorexia, and low mortality...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28816992/are-physician-assistants-needed-in-guatemala-a-survey-of-potential-urban-and-rural-users
#2
Claudia Luna-Asturias, Jennifer Apple, Guillermo A Bolaños, Jonathan M Bowser, Edwin J Asturias
PURPOSE: The shortage of trained health care personnel has been increasing worldwide. With the physician assistant (PA) profession, created in the United States in the 1960s, expanding globally, this study sought to ascertain whether PAs can be an innovative solution to this crisis. METHODS: We conducted a convenience sample survey to assess the need for and acceptability of future PA professionals in Guatemala. Eighty-nine doctors, nurses, and community members from rural and urban areas of Guatemala participated in the survey...
September 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28816860/management-of-chronic-hepatitis-b-in-pregnancy
#3
Jie Li, Matthew S Chang, Tram T Tran, Mindie H Nguyen
Chronic hepatitis B virus (HBV) infection due to mother-to-child transmission during the perinatal period remains an important global health problem. Despite standard passive-active immunoprophylaxis with hepatitis B immunoglobulin and hepatitis B vaccine in neonates, up to 8.5% of newborns still acquire HBV infection. Thus, management of chronic HBV during pregnancy and strategies to prevent mother-to-child transmission are important steps in eradicating or reducing the global burden of chronic HBV infection...
August 14, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28814285/quality-of-midwife-provided-intrapartum-care-in-amhara-regional-state-ethiopia
#4
Tegbar Yigzaw, Fantu Abebe, Lalem Belay, Yewulsew Assaye, Equlinet Misganaw, Ashebir Kidane, Desalegn Ademie, Jos van Roosmalen, Jelle Stekelenburg, Young-Mi Kim
BACKGROUND: Despite much progress recently, Ethiopia remains one of the largest contributors to the global burden of maternal and newborn deaths and stillbirths. Ethiopia's plan to meet the sustainable development goals for maternal and child health includes unprecedented emphasis on improving quality of care. The purpose of this study was to assess the quality of midwifery care during labor, delivery and immediate postpartum period. METHODS: A cross-sectional study using multiple data collection methods and a 2-stage cluster sampling technique was conducted from January 25 to February 14, 2015 in government health facilities of the Amhara National Regional State of Ethiopia...
August 16, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28812841/university-of-global-health-equity-s-contribution-to-the-reduction-of-education-and-health-services-rationing
#5
EDITORIAL
Agnes Binagwaho
The inadequate supply of health workers and demand-side barriers due to clinical practice that heeds too little attention to cultural context are serious obstacles to achieving universal health coverage and the fulfillment of the human rights to health, especially for the poor and vulnerable living in remote rural areas. A number of strategies have been deployed to increase both the supply of healthcare workers and the demand for healthcare services. However, more can be done to improve service delivery as well as mitigate the geographic inequalities that exist in this field...
May 29, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28806082/the-discovery-of-novel-antimalarial-aminoxadiazoles-as-a-promising-nonendoperoxide-scaffold
#6
Elena Sandoval, María José Lafuente-Monasterio, María J Almela, Pablo Castañeda, María Belén Jiménez Díaz, María S Martínez-Martínez, Jaume Vidal, Íñigo Angulo-Barturen, Paul Bamborough, Jeremy Burrows, Nicholas Cammack, María J Chaparro, José M Coterón, Cristina de Cozar, Benigno Crespo, Beatriz Díaz, Gerard Drewes, Esther Fernández, Santiago Ferrer-Bazaga, María Teresa Fraile, Francisco J Gamo, Sonja Ghidelli-Disse, Rubén Gómez, John Haselden, Sophie Huss, María Luisa León, Jaime de Mercado, Simon J F Macdonald, José Ignacio Martín Hernando, Sara Prats, Margarita Puente, Anne Rodríguez, Juan C de la Rosa, Lourdes Rueda, Carolyn Selenski, Paul Willis, David M Wilson, Michael Witty, Félix Calderón
Since the appearance of resistance to the current front-line antimalarial treatments, ACTs (artemisinin combination therapies), the discovery of novel chemical entities to treat the disease is recognized as a major global health priority. From the GSK antimalarial set, we identified an aminoxadiazole with an antiparasitic profile comparable with artemisinin (1), with no cross-resistance in a resistant strains panel and a potential new mode of action. A medicinal chemistry program allowed delivery of compounds such as 19 with high solubility in aqueous media, an acceptable toxicological profile, and oral efficacy...
August 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28802822/stillbirth-prevalence-in-brazil-an-exploration-of-regional-differences
#7
Taiana Silva Carvalho, Pat Doyle, Lucia Campos Pellanda
INTRODUCTION: Brazil is a large, heterogeneous, and diverse country, marked by social, economic, and regional inequalities. Stillbirth is a global concern, especially in low- and middle-income countries. This study investigated the prevalence and possible determinants of stillbirth in different regions of Brazil. METHODS: This is a cross-sectional study including all women of reproductive age who had had a pregnancy in the last five years, enrolled in the most recent Brazilian Demographic and Health Survey (DHS/PNDS-2006/07)...
August 9, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28802757/the-typhoid-vaccine-acceleration-consortium-tyvac-vaccine-effectiveness-study-designs-accelerating-the-introduction-of-typhoid-conjugate-vaccines-and-reducing-the-global-burden-of-enteric-fever-report-from-a-meeting-held-on-26-27-october-2016-oxford-uk
#8
James E Meiring, Malick Gibani
Typhoid fever is estimated to cause between 11.9-26.9 million infections globally each year with 129,000-216,510 deaths. Access to improved water sources have reduced disease incidence in parts of the world but the use of efficacious vaccines is seen as an important public health tool for countries with a high disease burden. A new generation of Vi typhoid conjugate vaccines (TCVs), licensed for use in young children and expected to provide longer lasting protection than previous vaccines, are now available...
August 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28798010/mobile-phone-detection-of-semantic-location-and-its-relationship-to-depression-and-anxiety
#9
Sohrab Saeb, Emily G Lattie, Konrad P Kording, David C Mohr
BACKGROUND: Is someone at home, at their friend's place, at a restaurant, or enjoying the outdoors? Knowing the semantic location of an individual matters for delivering medical interventions, recommendations, and other context-aware services. This knowledge is particularly useful in mental health care for monitoring relevant behavioral indicators to improve treatment delivery. Local search-and-discovery services such as Foursquare can be used to detect semantic locations based on the global positioning system (GPS) coordinates, but GPS alone is often inaccurate...
August 10, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28797861/the-worldwide-hospice-palliative-care-alliance
#10
Stephen R Connor
The Worldwide Hospice Palliative Care Alliance (WHPCA) is an international non-governmental organization registered as a charity in England and Wales that was established in 2008 following a series of international gatherings that highlighted the important need for palliative care to be included in global policy and health planning. The vision of the WHPCA is a world with universal access to hospice and palliative care. Its mission is to foster, promote and influence the delivery of affordable, quality palliative care...
August 7, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28795920/risk-factors-associated-with-neonatal-deaths-a-matched-case-control-study-in-indonesia
#11
Asnawi Abdullah, Krishna Hort, Yuli Butu, Louise Simpson
Background Similar to global trends, neonatal mortality has fallen only slightly in Indonesia over the period 1990-2010, with a high proportion of deaths in the first week of life. Objective This study aimed to identify risk factors associated with neonatal deaths of low and normal birthweight infants that were amenable to health service intervention at a community level in a relatively poor province of Indonesia. Design A matched case-control study of neonatal deaths reported from selected community health centres (puskesmas) was conducted over 10 months in 2013...
December 2016: Global Health Action
https://www.readbyqxmd.com/read/28792376/construction-of-an-inactivated-typhoid-vaccine-candidate-expressing-escherichia-coli-heat-labile-enterotoxin-b-subunit-and-evaluation-of-its-immunogenicity-in-a-murine-model
#12
Boram Kim, Gayeon Won, John Hwa Lee
PURPOSE: Typhoid fever caused by Salmonella enterica serovar Typhi has contributed to the global public health burden, particularly in developing countries. In this study, an S. Typhi ghost was developed and its capacity as a vaccine candidate against typhoid fever was assessed. METHODOLOGY: An asd+ plasmid pJHL187 harbouring a ghost cassette comprising the PhiX 174 Elysis gene tightly controlled under the convergent promotor system was transformed into an asd gene-deleted mutant S...
August 10, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28791282/the-global-health-service-partnership-an-academic-clinical-partnership-to-build-nursing-and-medical-capacity-in-africa
#13
REVIEW
Eileen M Stuart-Shor, Elizabeth Cunningham, Laura Foradori, Elizabeth Hutchinson, Martha Makwero, Jill Smith, Jane Kasozi, Esther M Johnston, Aliasgar Khaki, Elisa Vandervort, Fabiola Moshi, Vanessa B Kerry
The World Health Organization estimates a global deficit of about 12.9 million skilled health professionals (midwives, nurses, and physicians) by 2035. These shortages limit the ability of countries, particularly resource-constrained countries, to deliver basic health care, to respond to emerging and more complex needs, and to teach, graduate, and retain their future health professionals-a vicious cycle that is perpetuated and has profound implications for health security. The Global Health Service Partnership (GHSP) is a unique collaboration between the Peace Corps, President's Emergency Plan for AIDS Relief, Seed and host-country institutions, which aims to strengthen the breadth and quality of medical and nursing education and care delivery in places with dire shortages of health professionals...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28777109/influenza-immunization-of-pregnant-women-in-resource-constrained-countries-an-update-for-funding-and-implementation-decisions
#14
Justin R Ortiz, Kathleen M Neuzil
PURPOSE OF REVIEW: In 2018, Gavi, the Vaccine Alliance, is expected to review the strategy of maternal influenza immunization for potential investment in low-income countries. RECENT FINDINGS: Clinical trial data confirm the efficacy of maternal influenza immunization to prevent influenza disease in both mothers and their infants during the first months of life. Trial and observational data indicate no significant adverse events in mothers or newborns. High-quality disease burden data, particularly for seasonal influenza in low-income and middle-income countries, are limited...
August 4, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28776463/prevalence-and-impact-of-sexually-transmitted-infections-in-pregnant-women-in-central-ethiopia
#15
Andreas Schönfeld, Torsten Feldt, Tafese B Tufa, Hans M Orth, André Fuchs, Million G Mesfun, Frieder Pfäfflin, Tamara Nordmann, Matthias Breuer, Monika Hampl, Dieter Häussinger
Human immunodeficiency virus (HIV) continues to be a major global public health issue and omnipresent sexually transmitted infections (STIs) increase the risk of HIV acquisition. Moreover, STIs and HIV in pregnant women can harm the unborn child. In this study, we systematically investigated the prevalence of HIV, relevant STIs and vaginal group B streptococcus colonization among pregnant women presenting at Asella Teaching Hospital in central Ethiopia and their effect on perinatal mortality. A follow-up was performed six weeks after delivery...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28774193/declining-clinical-course-of-psychotic-disorders-over-the-two-decades-following-first-hospitalization-evidence-from-the-suffolk-county-mental-health-project
#16
Roman Kotov, Laura Fochtmann, Kaiqiao Li, Marsha Tanenberg-Karant, Eduardo A Constantino, Joan Rubinstein, Greg Perlman, Eva Velthorst, Anne-Kathrin J Fett, Gabrielle Carlson, Evelyn J Bromet
OBJECTIVE: Kraepelin considered declining course a hallmark of schizophrenia, but others have suggested that outcomes usually stabilize or improve after treatment initiation. The authors investigated this question in an epidemiologically defined cohort with psychotic disorders followed for 20 years after first hospitalization. METHOD: The Suffolk County Mental Health Project recruited first-admission patients with psychosis from all inpatient units of Suffolk County, New York (response rate, 72%)...
August 4, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28765463/dental-group-practice-and-the-need-for-dentists
#17
David S Gesko, Howard L Bailit
This study compared the number of patients treated per year by general dentists and dental hygienists in solo practice and by those employed by a large group practice. Information on the annual number of patient visits to solo general dental practitioners comes from the 2013 American Dental Association (ADA) Survey of Dental Practice. Patient visits were divided by 2.5 to estimate the number of patients treated annually. The data on group practices come from HealthPartners (HP) of Minnesota, a large not-for-profit medical and dental Health Maintenance Organization that accepts insurance contracts based on global budgets and is financially at risk...
August 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28763449/identification-of-factors-associated-with-stillbirth-in-the-indian-state-of-bihar-using-verbal-autopsy-a-population-based-study
#18
Rakhi Dandona, G Anil Kumar, Amit Kumar, Priyanka Singh, Sibin George, Mohammad Akbar, Lalit Dandona
BACKGROUND: India was estimated to have the largest numbers of stillbirths globally in 2015, and the Indian government has adopted a target of <10 stillbirths per 1,000 births by 2030 through the India Newborn Action Plan (INAP). The objective of this study was to use verbal autopsy interviews to examine factors associated with stillbirth in the Indian state of Bihar and make recommendations for the INAP to better inform the setting of priorities and actions to reduce stillbirths. METHODS AND FINDINGS: Verbal autopsy interviews were conducted for deaths including stillbirths that occurred from January 2011 to March 2014 in a sample of 109,689 households (87...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28760934/next-generation-probiotics-targeting-clostridium-difficile-through-precursor-directed-antimicrobial-biosynthesis
#19
Jennifer K Spinler, Jennifer Auchtung, Aaron Brown, Prapaporn Boonma, Numan Oezguen, Caná L Ross, Ruth Ann Luna, Jessica Runge, James Versalovic, Alex Peniche, Sara M Dann, Robert A Britton, Anthony Haag, Tor C Savidge
Integration of antibiotic and probiotic therapy has the potential to lessen the public health burden to antimicrobial-associated diseases. Clostridium difficile infection (CDI) represents an important example where rational design of next generation probiotics is being actively pursued to prevent disease recurrence. Because intrinsic resistance to clinically relevant CDI antibiotics (vancomycin, metronidazole, and fidaxomicin) is a desired trait in such probiotic species, we screened several bacteria and identified Lactobacillus reuteri as a promising candidate for adjunct therapy...
July 31, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28760096/collaborative-care-for-mental-health-in-low-and-middle-income-countries-a-who-health-systems-framework-assessment-of-three-programs
#20
Bibhav Acharya, Maria Ekstrand, Pragya Rimal, Mohammed K Ali, Sikhar Swar, Krishnamachari Srinivasan, Viswanathan Mohan, Jürgen Unützer, Lydia A Chwastiak
The collaborative care model is an evidence-based intervention for behavioral and other chronic conditions that has the potential to address the large burden of mental illness globally. Using the World Health Organization Health Systems Framework, the authors present challenges in implementing this model in low- and middle-income countries (LMICs) and discuss strategies to address these challenges based on experiences with three large-scale programs: an implementation research study in a district-level government hospital in rural Nepal, one clinical trial in 50 primary health centers in rural India, and one study in four diabetes clinics in India...
August 1, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
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