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https://www.readbyqxmd.com/read/29033567/nanoparticles-for-the-treatment-of-liver-fibrosis
#1
REVIEW
Suchithra Poilil Surendran, Reju George Thomas, Myeong Ju Moon, Yong Yeon Jeong
Chronic liver diseases represent a global health problem due to their high prevalence worldwide and the limited available curative treatment options. They can result from various causes, both infectious and noninfectious diseases. The application of nanoparticle (NP) systems has emerged as a rapidly evolving area of interest for the safe delivery of various drugs and nucleic acids for chronic liver diseases. This review presents the pathogenesis, diagnosis and the emerging nanoparticulate systems used in the treatment of chronic liver diseases caused by liver fibrosis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29033005/adhd-in-children-and-young-people-prevalence-care-pathways-and-service-provision
#2
REVIEW
Kapil Sayal, Vibhore Prasad, David Daley, Tamsin Ford, David Coghill
Attention-deficit hyperactivity disorder (ADHD) is a common childhood behavioural disorder. Systematic reviews indicate that the community prevalence globally is between 2% and 7%, with an average of around 5%. At least a further 5% of children have substantial difficulties with overactivity, inattention, and impulsivity that are just under the threshold to meet full diagnostic criteria for ADHD. Estimates of the administrative prevalence (clinically diagnosed or recorded) vary worldwide, and have been increasing over time...
October 9, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/29027039/patterns-of-alcohol-abuse-depression-and-intimate-partner-violence-among-township-mothers-in-south-africa-over-5-years
#3
Emily C Davis, Mary Jane Rotheram-Borus, Thomas W Weichle, Roxana Rezai, Mark Tomlinson
Alcohol is a major contributor to the global burden of disease. In South Africa, alcohol abuse is hypothesized to correlate with women's HIV status, mental health, and partner relationships over time. All pregnant women in 12 urban, low-income, Cape Town neighborhoods were interviewed at baseline, post-birth, and at 6, 12, 36, and 60 months following delivery with retention rates from 82.5 to 94%. Women were assessed for any alcohol use, problematic drinking, depression, intimate partner violence, and HIV status...
October 12, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29026432/timely-initiation-of-breastfeeding-and-its-association-with-birth-place-in-ethiopia-a-systematic-review-and-meta-analysis
#4
REVIEW
Animut Alebel, Getiye Dejenu, Getachew Mullu, Nurilign Abebe, Tenaw Gualu, Setegn Eshetie
BACKGROUND: Timely initiation of breastfeeding is defined as putting the newborn to the breast within 1 h of birth. In Ethiopia, different studies have been conducted to assess the prevalence of timely initiation of breastfeeding and associated factors. The findings of these studies were inconsistent and characterized by great variability. Therefore, the aim of this systematic review and meta-analysis was to estimate the pooled prevalence of timely initiation of breastfeeding and its association with birth place in Ethiopia using the available studies...
2017: International Breastfeeding Journal
https://www.readbyqxmd.com/read/29025215/regenerative-cells-for-the-management-of-osteoarthritis-and-joint-disorders-a-concise-literature-review
#5
Travis J Block, Jaime R Garza
As the global population ages, the prevalence of osteoarthritis (OA) and joint disorders represent a major cause of disability and a significant public health burden. As current approaches for the management of OA focus on slowing the progression of disease, without repairing the underlying damage, novel treatments are necessary to improve outcomes. Over the past decade, autologous cell-based therapies using regenerative cells from fat or bone marrow have become a major focus of research into new approaches for the treatment of osteoarthritis and joint disorders...
July 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29023522/microencapsulation-of-clostridium-difficile-specific-bacteriophages-using-microfluidic-glass-capillary-devices-for-colon-delivery-using-ph-triggered-release
#6
Gurinder K Vinner, Goran T Vladisavljević, Martha R J Clokie, Danish J Malik
The prevalence of pathogenic bacteria acquiring multidrug antibiotic resistance is a global health threat to mankind. This has motivated a renewed interest in developing alternatives to conventional antibiotics including bacteriophages (viruses) as therapeutic agents. The bacterium Clostridium difficile causes colon infection and is particularly difficult to treat with existing antibiotics; phage therapy may offer a viable alternative. The punitive environment within the gastrointestinal tract can inactivate orally delivered phages...
2017: PloS One
https://www.readbyqxmd.com/read/29021978/global-health-teaching-in-india-a-curricular-landscape
#7
REVIEW
Sanghamitra Pati, Rajeshwari Sinha, Meely Panda, Sandipana Pati, Anjali Sharma, Sanjay Zodpey
Today, health has transcended national boundaries and become more multifaceted. Global health has evolved as a new paradigm and is recently being identified as a thrust area now in India. Despite an existing need for a standardized global health curriculum, there is little information available on its education and curriculum in medical and health education space. In the Indian context, we are yet to have a fuller picture of the current status, including, content, structure, selection, teaching methods of global health, and how students are evaluated in India...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29020047/correlates-of-institutional-deliveries-among-teenage-and-non-teenage-mothers-in-nepal
#8
Pawan Acharya, Tara Ballav Adhikari, Dipika Neupane, Kiran Thapa, Parash Mani Bhandari
INTRODUCTION: Globally, maternal age is identified as an important predictor of institutional service utilization during delivery. This study aims to assess the correlates of institutional delivery among teenage and non-teenage mothers in Nepal by using the data from Nepal Demographic and Health Survey 2011. METHODS: The study population consisted of 5391 women of reproductive age (15-49 years) who had given birth to a child within five years before the survey. Out of them, 381 (7...
2017: PloS One
https://www.readbyqxmd.com/read/28985514/visceral-adipose-tissue-macrophage-targeted-tace-silencing-to-treat-obesity-induced-type-2-diabetes
#9
Seok-Beom Yong, Yoonsung Song, Yong-Hee Kim
Obesity is an increasingly prevalent global health problem. Due to its close relations with metabolic diseases and cancer, new therapeutic approaches for treating obesity and obesity-induced metabolic diseases are required. Visceral white adipose tissue (WAT) has been closely associated with obesity-induced inflammation and adipose tissue macrophages (ATMs) are responsible for obesity-induced inflammation by releasing inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6. TNF-α converting enzyme (TACE) is a transmembrane enzyme that induces the enzymatic cleavage and release of inflammatory cytokines...
December 2017: Biomaterials
https://www.readbyqxmd.com/read/28981663/institutionalizing-and-sustaining-social-change-in-health-systems-the-case-of-uganda
#10
Jerald Hage, Joseph J Valadez
The key to high impact health services is institutionalizing and sustaining programme evaluation. Uganda represents a success story in the use of a specific programme evaluation method: Lot Quality Assurance Sampling (LQAS). Institutionalization is defined by two C's: competent programme evaluators and control mechanisms that effectively use evaluation data to improve health services. Sustainability means continued training and funding for the evaluation approach. Social science literature that researches institutionalization has emphasized 'stability', whereas in global health, the issue is determining how to improve the impact of services by 'changing' programmes...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28980059/avoiding-implementation-failure-in-catchment-landscapes-a-case-study-in-governance-of-the-great-barrier-reef
#11
Allan P Dale, Karen Vella, Margaret Gooch, Ruth Potts, Robert L Pressey, Jon Brodie, Rachel Eberhard
Water quality outcomes affecting Australia's Great Barrier Reef (GBR) are governed by multi-level and multi-party decision-making that influences forested and agricultural landscapes. With international concern about the GBR's declining ecological health, this paper identifies and focuses on implementation failure (primarily at catchment scale) as a systemic risk within the overall GBR governance system. There has been limited integrated analysis of the full suite of governance subdomains that often envelop defined policies, programs and delivery activities that influence water quality in the GBR...
October 4, 2017: Environmental Management
https://www.readbyqxmd.com/read/28974255/comparison-of-patient-perceived-primary-care-quality-in-public-clinics-public-hospitals-and-private-clinics-in-rural-china
#12
Wenhua Wang, Elizabeth Maitland, Stephen Nicholas, Ekaterina Loban, Jeannie Haggerty
BACKGROUND: In rural China, patients have free choice of health facilities for outpatient services. Comparison studies exploring the attributes of different health facilities can help identify optimal primary care service models. Using a representative sample of Chinese provinces, this study aimed to compare patients' rating of three primary care service models used by rural residents (public clinics, public hospitals and private clinics) on a range of health care attributes related to responsiveness...
October 3, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28970034/diabetes-structured-self-management-education-programmes-a-narrative-review-and-current-innovations
#13
REVIEW
Sudesna Chatterjee, Melanie J Davies, Simon Heller, Jane Speight, Frank J Snoek, Kamlesh Khunti
Both type 1 and type 2 diabetes are associated with long-term complications that can be prevented or delayed by intensive glycaemic management. People who are empowered and skilled to self-manage their diabetes have improved health outcomes. Over the past 20 years, diabetes self-management education programmes have been shown to be efficacious and cost-effective in promotion and facilitation of self-management, with improvements in patients' knowledge, skills, and motivation leading to improved biomedical, behavioural, and psychosocial outcomes...
September 29, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28965508/addressing-barriers-to-exclusive-breast-feeding-in-low-and-middle-income-countries-a-systematic-review-and-programmatic-implications
#14
Justine A Kavle, Elizabeth LaCroix, Hallie Dau, Cyril Engmann
OBJECTIVE: Despite numerous global initiatives on breast-feeding, trend data show exclusive breast-feeding (EBF) rates have stagnated over the last two decades. The purpose of the present systematic review was to determine barriers to exclusive breast-feeding in twenty-five low- and middle-income countries and discuss implications for programmes. DESIGN: A search of Scopus, MEDLINE, CINAHL and PsychINFO was conducted to retrieve studies from January 2000 to October 2015...
October 2, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28965203/assessment-of-carrot-callus-as-biofactories-of-an-atherosclerosis-oral-vaccine-prototype
#15
Dania O Govea-Alonso, Marlene A Tello-Olea, Josué Beltrán-López, Elizabeth Monreal-Escalante, Jorge A Salazar-Gonzalez, Bernardo Bañuelos-Hernández, Sergio Rosales-Mendoza
Atherosclerosis is a pathology leading to cardiovascular diseases with high epidemiologic impact; thus, new therapies are required to fight this global health issue. Immunotherapy is a feasible approach to treat atherosclerosis and given that genetically engineered plants are attractive hosts for vaccine development; we previously proved that the plant cell is able to synthesize a chimeric protein called CTB:p210:CETPe, which is composed of the cholera toxin B subunit (CTB) as immunogenic carrier and target epitopes from the cholesteryl ester transfer protein (CETP461-476) and apolipoprotein B100 (p210)...
September 30, 2017: Molecular Biotechnology
https://www.readbyqxmd.com/read/28965098/study-protocol-for-a-longitudinal-study-evaluating-the-impact-of-rape-on-women-s-health-and-their-use-of-health-services-in-south-africa
#16
Naeemah Abrahams, Soraya Seedat, Carl Lombard, Andre P Kengne, Bronwyn Myers, Alesha Sewnath, Shibe Mhlongo, Gita Ramjee, Nasheeta Peer, Claudia Garcia-Moreno, Rachel Jewkes
INTRODUCTION: South Africa is a country known for its high levels of HIV infection and sexual violence. Although the interface between gender-based violence, HIV and mental health has been described, there are substantial gaps in knowledge of the medium-term and long-term health impact. The 2010 Global Burden of Disease study excluded many health outcomes associated with rape and other forms of gender-based violence because systematic reviews revealed huge gaps in data and poor evidence of health effects...
September 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28962649/adolescent-deliveries-in-rural-cameroon-an-8-year-trend-prevalence-and-adverse-maternofoetal-outcomes
#17
Valirie Ndip Agbor, Clarence Mvalo Mbanga, Tsi Njim
BACKGROUND: Adolescent deliveries remain a global public health concern especially in low- and middle-income countries where 95% of these deliveries occur. In Cameroon, adolescent pregnancies have a high disease burden due to their association with adverse pregnancy outcomes. We sought to evaluate the prevalence, trend and adverse maternofoetal outcomes of adolescent deliveries in a rural community in Cameroon. METHOD: We carried out a retrospective register analysis of 1803 singleton deliveries in two health facilities located in the Oku sub-division over an 8-year period (2009 to 2016)...
September 29, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28962564/introducing-leprosy-post-exposure-prophylaxis-into-the-health-systems-of-india-nepal-and-indonesia-a-case-study
#18
A Tiwari, L Mieras, K Dhakal, M Arif, S Dandel, J H Richardus
BACKGROUND: Leprosy has a wide range of clinical and socio-economic consequences. India, Indonesia and Nepal contribute significantly to the global leprosy burden. After integration, the health systems are pivotal in leprosy service delivery. The Leprosy Post Exposure Prophylaxis (LPEP) program is ongoing to investigate the feasibility of providing single dose rifampicin (SDR) as post-exposure prophylaxis (PEP) to the contacts of leprosy cases in various health systems. We aim to compare national leprosy control programs, and adapted LPEP strategies in India, Nepal and Indonesia...
September 29, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28961835/mapping-unmet-supportive-care-needs-quality-of-life-perceptions-and-current-symptoms-in-cancer-survivors-across-the-asia-pacific-region-results-from-the-international-step-study
#19
A Molassiotis, P Yates, Q Li, W K W So, K Pongthavornkamol, P Pittayapan, H Komatsu, M Thandar, M-S Li, S Titus Chacko, V Lopez, J Butcon, D Wyld, R J Chan
Background: To assess the supportive care needs, quality of life (QoL) and symptoms of patients with cancer after the end of first-line treatments and into survivorship in Asian countries using Australian data as benchmark. Patients and methods: A cross-sectional survey was carried out in Australia and eight high-income (HICs) and low-/middle-income (LMICs) Asian countries (China, Japan, Hong Kong SAR, South Korea, Myanmar, Thailand, India, Philippines) using validated scales (Cancer Survivors Unmet Needs scale), physical-symptom concerns (Cancer Survivors Survey of Needs subscale) and a single-item measure of global QoL perception...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28961628/observations-on-the-global-spread-of-physician-assistant-education
#20
Ruth M Ballweg, Roderick S Hooker
The physician assistant concept was developed in the 1960s as a response to the shortage and uneven distribution of generalist doctors. The goal was to increase the public's access to health care. After a half century of development and implementation, the PA model has become a global strategy to augment medical service delivery. In many instances the introduction of the PA was successful. Elsewhere it is in the early stages of development. The name may be modified depending on the country: "physician associate," "clinical assistant," "associate physician" are alternatives...
October 2017: Journal of Physician Assistant Education
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