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https://www.readbyqxmd.com/read/28525513/an-observational-assessment-of-anesthesia-capacity-in-madagascar-as-a-prerequisite-to-the-development-of-a-national-surgical-plan
#1
Linden S Baxter, Vaonandianina A Ravelojaona, Hasiniaina N Rakotoarison, Alison Herbert, Emily Bruno, Kristin L Close, Vanessa Andean, Hery H Andriamanjato, Mark G Shrime, Michelle C White
BACKGROUND: The global lack of anesthesia capacity is well described, but country-specific data are needed to provide country-specific solutions. We aimed to assess anesthesia capacity in Madagascar as part of the development of a Ministry of Health national surgical plan. METHODS: As part of a nationwide surgical safety quality improvement project, we surveyed 19 of 22 regional hospitals, representing surgical facilities caring for 75% of the total population. The assessment was divided into 3 areas: anesthesia workforce density, infrastructure and equipment, and medications...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28522424/cyclodextrin-based-nanocarriers-containing-a-synergic-drug-combination-a-potential-formulation-for-pulmonary-administration-of-antitubercular-drugs
#2
Giuseppina Salzano, Jitendra Wankar, Stefano Ottani, Baptiste Villemagne, Alain R Baulard, Nicolas Willand, Priscille Brodin, Ilse Manet, Ruxandra Gref
Tuberculosis (TB) remains a major global health problem. The use of ethionamide (ETH), a main second line drug, is associated to severe toxic side-effects due to its low therapeutic index. In this challenging context, "booster" molecules have been synthetized to increase the efficacy of ETH. However, the administration of ETH/booster pair is mostly hampered by the low solubility of these drugs and the tendency of ETH to crystallize. Here, ETH and a poorly water-soluble booster, so-called BDM43266, were simultaneously loaded in polymeric β-cyclodextrin nanoparticles (pβCyD NPs) following a "green" protocol...
May 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28513261/rainer-gross-award-lecture-2016
#3
Saurabh Mehta, Susannah Colt, Seoho Lee, David Erickson
The need for improving methods of nutritional assessment and delivering primary health care globally cannot be overemphasized. While advances in medical technology typically create more disparities because of access being limited to resource-rich settings, a transition of health care to a mobile platform is increasingly leveling the field. Technological advances offer opportunities to scale laboratory procedures down to mobile devices, such as smartphones and tablets. Globalization also provides the required infrastructure and network capacity to support the use of mobile health devices in developing settings where nutritional deficiencies are most prevalent...
June 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28506226/institutional-delivery-service-utilization-and-associated-factors-among-women-of-reproductive-age-in-the-mobile-pastoral-community-of-the-liban-district-in-guji-zone-oromia-southern-ethiopia-a-cross-sectional-study
#4
Wako Golicha Wako, Dejene Hailu Kassa
BACKGROUND: Globally, an estimated 289,000 maternal deaths occurred in 2013. Majority of these deaths occurred in sub-Saharan Africa and Southern Asia. Mobility of pastoralists is a well-recognized survival strategy in arid and semi-arid land of sub-Saharan Africa. However governments often encourage settlement as a solution to the difficulty of providing health services for mobile pastoralists. This study aimed to assess utilization of institutional delivery and associated factors among women of reproductive age in the mobile pastoral community of the Liban District in Guji zone, Oromia, Ethiopia...
May 15, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28503310/individual-capacity-building-approaches-in-a-global-pharmaceutical-systems-strengthening-program-a-selected-review
#5
Niranjan Konduri, Megan Rauscher, Shiou-Chu Judy Wang, Tanya Malpica-Llanos
BACKGROUND: Medicines use related challenges such as inadequate adherence, high levels of antimicrobial resistance and preventable adverse drug reactions have underscored the need to incorporate pharmaceutical services to help achieve desired treatment outcomes, and protect patients from inappropriate use of medicines. This situation is further constrained by insufficient numbers of pharmaceutical personnel and inappropriate skill mix. Studies have addressed individual capacity building approaches of logistics, supply chain or disease specific interventions but few have documented those involving such pharmacy assistants/professionals, or health workers/professionals charged with improving access and provision of pharmaceutical services...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/28498179/improving-retention-in-care-among-pregnant-women-and-mothers-living-with-hiv-lessons-from-inspire-and-implications-for-future-who-guidance-and-monitoring
#6
Nigel C Rollins, Shaffiq M Essajee, Nita Bellare, Meg Doherty, Gottfried O Hirnschall
Identifying women living with HIV, initiating them on lifelong antiretroviral treatment (ART), and retaining them in care are among the important challenges facing this generation of health care managers and public health researchers. Implementation research attempts to solve a wide range of implementation problems by trying to understand and work within real-world conditions to find solutions that have a measureable impact on the outcomes of interest. Implementation research is distinct from clinical research in many ways yet demands similar standards of conceptual thinking and discipline to generate robust evidence that can be, to some extent, generalized to inform policy and service delivery...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28493966/improving-drug-delivery-strategies-for-lymphatic-filariasis-elimination-in-urban-areas-in-ghana
#7
Nana-Kwadwo Biritwum, Bertha Garshong, Bright Alomatu, Dziedzom K de Souza, Margaret Gyapong, Dominique Kyelem
The Global Program to Eliminate Lymphatic Filariasis (GPELF) advocates for the treatment of entire endemic communities, in order to achieve its elimination targets. LF is predominantly a rural disease, and achieving the required treatment coverage in these areas is much easier compared to urban areas that are more complex. In Ghana, parts of the Greater Accra Region with Accra as the capital city are also endemic for LF. Mass Drug Administration (MDA) in Accra started in 2006. However, after four years of treatment, the coverage has always been far below the 65% epidemiologic coverage for interrupting transmission...
May 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28493177/what-is-single-payer-health-care-a-review-of-definitions-and-proposals-in-the-u-s
#8
Jodi L Liu, Robert H Brook
BACKGROUND: Single-payer systems have been proposed as a health care reform alternative in the United States. However, there is no consensus on the definition of single-payer. Most definitions characterize single-payer as one entity that collects funds and pays for health care on behalf on an entire population. Increased flexibility for state health care reform may provide opportunities for state-based single-payer systems to be considered. OBJECTIVE: To explore the concept of single-payer and to describe the contents of single-payer health care proposals...
May 10, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28491125/indirect-maternal-deaths-uk-and-global-perspectives
#9
Manisha Nair, Catherine Nelson-Piercy, Marian Knight
Indirect maternal deaths outnumber direct deaths due to obstetric causes in many high-income countries, and there has been a significant increase in the proportion of maternal deaths due to indirect medical causes in low- to middle-income countries. This review presents a detailed analysis of indirect maternal deaths in the UK and a perspective on the causes and trends in indirect maternal deaths and issues related to care in low- to middle-income countries. There has been no significant decrease in the rate of indirect maternal deaths in the UK since 2003...
March 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/28490424/waning-immunity-and-microbial-vaccines-workshop-of-the-national-institute-of-allergy-and-infectious-diseases
#10
Xin-Xing Gu, Stanley A Plotkin, Kathryn M Edwards, Alessandro Sette, Kingston H G Mills, Ofer Levy, Andrea J Sant, Annie Mo, William Alexander, Kristina T Lu, Christopher E Taylor
Since the middle of the 20th century, vaccines have made a significant public health impact controlling infectious diseases globally. Although long-term protection has been achieved with some vaccines, immunity wanes over time with others, resulting in outbreaks or epidemics of infectious diseases. Long-term protection against infectious agents with complex life cycles and antigenic variation remains a key challenge. Novel strategies to characterize the short and long-term immune responses to vaccines, and to induce immune responses that mimic natural infection have recently emerged...
May 10, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28487305/a-rohingya-refugee-s-journey-in-australia-and-the-barriers-to-accessing-healthcare
#11
Manasi Jiwrajka, Ahmad Mahmoud, Maneeta Uppal
Australia's processing of some asylum seekers on offshore detention centres has recently been brought to light by human rights organisation. While the internal politics of resettling refugees may be complex, Australia remains in the top five countries for resettlement per capita. However, these refugees remain a vulnerable patient population after immigrating. Refugee women, an understudied group, in particular experience higher adverse health outcomes.In this case report, we follow the medical journey of KB, a 38-year-old Rohingya refugee diagnosed with type 2 diabetes mellitus-the crux of all her health issues...
May 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28486654/oxygen-availability-and-nursing-capacity-for-oxygen-therapy-in-ugandan-paediatric-wards
#12
Juliet Nabwire, Sophie Namasopo, Michael Hawkes
Oxygen is essential, life-saving, supportive treatment for children with hypoxaemia but is not available in many resource-constrained health facilities. We conducted a cross-sectional survey of oxygen availability and nurses' skills for oxygen administration at the paediatric wards of 11 district hospitals in eastern Uganda. Functional oxygen delivery was available at the paediatric wards of only 2 of 11 (18%) hospitals. Of the six concentrators found, two did not function at all and two produced a stream of O2 <80% pure...
May 8, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28479888/pattern-of-utilization-of-ante-natal-and-delivery-services-in-a-semi-urban-community-of-north-central-nigeria
#13
Jimoh Maryam Abimbola, Akande Tanimola Makanjuola, Salaudeen Adekunle Ganiyu, Uthman Mohammed Mubashir Babatunde, Durowade Kabir Adekunle, Aremu Ayodele Olatayo
BACKGROUND: Nigeria accounts for only 2% of the world's population, but contributes up to 10 % of the global estimates of maternal deaths. The study assesses the utilization of antenatal and delivery services by women of reproductive age in Afon community. METHODOLOGY: It was a descriptive cross-sectional study that collected both quantitative and qualitative data using semi-structured interviewer administered questionnaire and focus group discussions (FGD). Interviews were house-hold based...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28477307/quality-indicators-in-headache-care-an-implementation-study-in-six-italian-specialist-care-centres
#14
L Pellesi, S Benemei, V Favoni, C Lupi, E Mampreso, A Negro, M Paolucci, T J Steiner, M Ulivi, S Cevoli, S Guerzoni
BACKGROUND: Headache disorders are highly prevalent, and have a substantial and negative impact on health worldwide. They are largely treatable, but differences in structure, objectives, organization and delivery affect the quality of headache care. In order to recognize and remedy deficiencies in care, the Global Campaign against Headache, in collaboration with the European Headache Federation, recently developed a set of quality indicators for headache services. These require further assessment to demonstrate fitness for purpose...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28475122/harnessing-local-immunity-for-an-effective-universal-swine-influenza-vaccine
#15
REVIEW
Elma Tchilian, Barbara Holzer
Influenza A virus infections are a global health threat to humans and are endemic in pigs, contributing to decreased weight gain and suboptimal reproductive performance. Pigs are also a source of new viruses of mixed swine, avian, and human origin, potentially capable of initiating human pandemics. Current inactivated vaccines induce neutralising antibody against the immunising strain but rapid escape occurs through antigenic drift of the surface glycoproteins. However, it is known that prior infection provides a degree of cross-protective immunity mediated by cellular immune mechanisms directed at the more conserved internal viral proteins...
May 5, 2017: Viruses
https://www.readbyqxmd.com/read/28474743/increases-in-caesarean-delivery-rates-and-change-of-perinatal-outcomes-in-low-and-middle-income-countries-a-hospital-level-analysis-of-two-who-surveys
#16
Yanjun Zhao, Jun Zhang, Javier Zamora, Joshua Peter Vogel, João P Souza, Kapila Jayaratne, Togoobaatar Ganchimeg, Eduardo Ortiz-Panozo, Bernardo Hernandez, Olufemi T Oladapo, Maria R Torloni, Naho Morisaki, Rintaro Mori, Cynthia Pileggi-Castro, Özge Tunçalp, Xiaoming Shen, Ana Pilar Betrán
BACKGROUND: Maternal and neonatal outcomes have improved substantially. During the same period, the caesarean delivery rate soared. The aim of this analysis was to determine whether an increase in caesarean rate was associated with an improvement in perinatal outcome at an institutional level in low- and middle-income countries. METHODS: The WHO Global Survey on Maternal and Perinatal Health (WHOGS) and the WHO Multi-Country Survey on Maternal and Newborn Health (WHOMCS) were two multi-country, facility-based, cross-sectional surveys conducted in 2004-08 and 2010-11, respectively...
May 5, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28473673/feasibility-of-implementing-chronic-care-model-in-the-malaysian-public-primary-care-setting
#17
F Ariffin, A S Ramli, M H Daud, J Haniff, S Abdul-Razak, S Selvarajah, V K Lee, S F Tong, M A Bujang
INTRODUCTION: Non-communicable diseases (NCD) is a global health threat. the Chronic Care Model (CCM) was proven effective in improving NCD management and outcomes in developed countries. Evidence from developing countries including Malaysia is limited and feasibility of CCM implementation has not been assessed. this study intends to assess the feasibility of public primary health care clinics (PHC) in providing care according to the CCM. METHODOLOGY: A cross-sectional survey was conducted to assess the public PHC ability to implement the components of CCM...
April 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28469988/polio-in-syria-problem-still-not-solved
#18
Ahmad Al-Moujahed, Fares Alahdab, Heba Abolaban, Leo Beletsky
The reappearance of polio in Syria in mid-2013, 18 years after it was eliminated from the country, manifests the public health catastrophe brought on by the civil war. Among the lessons learned, this outbreak emphasizes the importance of increasing the international financial and logistical support for vaccine and immunization efforts, especially in countries suffering from conflicts. The lack of access to polio accredited laboratory or outright lack of laboratories in settings of conflict should be recognized allowing international surveillance to be strengthened by supplementing the laboratory definition with the clinical definition...
April 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28464878/-it-s-a-waiting-game-a-qualitative-study-of-the-experience-of-carers-of-patients-who-require-an-alternate-level-of-care
#19
Kerry Kuluski, Jennifer Im, Mary McGeown
BACKGROUND: Delayed hospital discharge (also known as Alternate Level of Care or ALC) is a global health care quality issue with negative implications for people (e.g., functional decline) and the health care system (e.g., costly interruptions in hospital flow and procedures). ALC disproportionately impacts people with cognitive impairment, and insight into the needs and experiences of this specific sub population and their carers is lacking. The purpose of this study was to understand the hospital experience of carers (e...
May 2, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28459105/crude-childhood-vaccination-coverage-in-west-africa-trends-and-predictors-of-completeness
#20
Jacob S Kazungu, Ifedayo M O Adetifa
Background: Africa has the lowest childhood vaccination coverage worldwide. If the full benefits of childhood vaccination programmes are to be enjoyed in sub-Saharan Africa, all countries need to improve on vaccine delivery to achieve and sustain high coverage. In this paper, we review trends in vaccination coverage, dropouts between vaccine doses and explored the country-specific predictors of complete vaccination in West Africa.  Methods: We utilized datasets from the Demographic and Health Surveys Program, available for Benin, Burkina Faso, The Gambia, Ghana, Guinea, Cote d'Ivoire, Liberia, Mali, Niger, Nigeria, Senegal, Sierra Leone and Togo, to obtain coverage for Bacillus Calmette-Guerin, polio, measles, and diphtheria, pertussis and tetanus (DPT) vaccines in children aged 12 - 23 months...
February 15, 2017: Wellcome Open Research
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