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https://www.readbyqxmd.com/read/27925153/targeting-the-hard-to-reach-challenges-and-novel-strategies-in-the-treatment-of-intracellular-bacterial-infections
#1
REVIEW
Nor Fadhilah Kamaruzzaman, Sharon Kendall, Liam Good
Infectious diseases continue to threaten human and animal health and welfare globally, impacting millions of lives and causing substantial economic loss. The use of antibacterials has been only partially successful in reducing disease impact. Bacterial cells are inherently resilient, and the therapy challenge is increased by the development of antibacterial resistance, the formation of biofilms and the ability of certain clinically important pathogens to invade and localize within host cells. Invasion into host cells provides protection from both antibacterials and the host immune system...
November 7, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27923009/counseling-framework-for-hiv-serodiscordant-couples-on-the-integrated-use-of-antiretroviral-therapy-and-pre-exposure-prophylaxis-for-hiv-prevention
#2
Jennifer F Morton, Connie Celum, John Njoroge, Agnes Nakyanzi, Imeldah Wakhungu, Edna Tindimwebwa, Snaidah Ongachi, Eric Sedah, Emmanuel Okwero, Kenneth Ngure, Josephine Odoyo, Nulu Bulya, Jessica E Haberer, Jared M Baeten, Renee Heffron
BACKGROUND: For HIV-serodiscordant couples, integrated delivery of antiretroviral therapy (ART) for HIV-positive partners and time-limited pre-exposure prophylaxis (PrEP) for negative partners virtually eliminates HIV transmission. Standardized messaging, sensitive to the barriers and motivators to HIV treatment and prevention, is needed for widespread scale-up of this approach. METHODS: Within the Partners Demonstration Project, a prospective interventional project among 1013 serodiscordant couples in Kenya and Uganda, we offered ART to eligible HIV-positive partners and PrEP to HIV-negative partners before ART initiation and through the HIV-positive partner's first 6 months of ART use...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27920772/streptococcus-thermophilus-apc151-strain-is-suitable-for-the-manufacture-of-naturally-gaba-enriched-bioactive-yogurt
#3
Daniel M Linares, Tom F O'Callaghan, Paula M O'Connor, R P Ross, Catherine Stanton
Consumer interest in health-promoting food products is a major driving force for the increasing global demand of functional (probiotic) dairy foods. Yogurt is considered the ideal medium for delivery of beneficial functional ingredients. Gamma-amino-butyric acid has potential as a bioactive ingredient in functional foods due to its health-promoting properties as an anti-stress, anti-hypertensive, and anti-diabetic agent. Here, we report the use of a novel Streptococcus thermophilus strain, isolated from the digestive tract of fish, for production of yogurt naturally enriched with 2 mg/ml of gamma-amino-butyric acid (200 mg in a standard yogurt volume of 100 ml), a dose in the same range as that provided by some commercially available gamma-amino-butyric acid supplements...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27920180/whole-inactivated-and-virus-like-particle-vaccine-strategies-for-chikungunya-virus
#4
Adam D DeZure, Nina M Berkowitz, Barney S Graham, Julie E Ledgerwood
Chikungunya virus (CHIKV) is a global public health threat, having been identified in >60 countries in Asia, Africa, Europe, and the Americas. There is no cure for or licensed vaccine against CHIKV infection. Initial attempts at CHIKV vaccine development began in the early 1960s. Whole-inactivated and virus-like particle (VLP) vaccines are 2 of the current approaches being evaluated. Success of these approaches is dependent on a safe, well-tolerated vaccine that is immunogenic and deployable in regard to manufacturing, stability, and delivery characteristics...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27919384/health-information-professionals-in-a-global-ehealth-world-ethical-and-legal-arguments-for-the-international-certification-and-accreditation-of-health-information-professionals
#5
Eike-Henner W Kluge
BACKGROUND: Issues such as privacy, security, quality, etc. have received considerable attention in discussions of eHealth, mHealth and pHealth. However, comparatively little attention has been paid to the fact that these methods of delivering health care situate Health Information Professionals (HIPs) in an ethical context that is importantly different from that of traditional health care because they assign a fiduciary role to HIPs that they did not have before, their previous technical involvement notwithstanding...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27918334/challenges-of-anesthesia-in-low-and-middle-income-countries-a-cross-sectional-survey-of-access-to-safe-obstetric-anesthesia-in-east-africa
#6
Isabella Epiu, Jossy Verel Bahe Tindimwebwa, Cephas Mijumbi, Thomas M Chokwe, Edwin Lugazia, Francois Ndarugirire, Theogene Twagirumugabe, Gerald Dubowitz
BACKGROUND: The United Nations 2015 Millennium Development Goals targeted a 75% reduction in maternal mortality. However, in spite of this goal, the number of maternal deaths per 100,000 live births remains unacceptably high across Sub-Saharan Africa. Because many of these deaths could likely be averted with access to safe surgery, including cesarean delivery, we set out to assess the capacity to provide safe anesthetic care for mothers in the main referral hospitals in East Africa. METHODS: A cross-sectional survey was conducted at 5 main referral hospitals in East Africa: Uganda, Kenya, Tanzania, Rwanda, and Burundi...
December 1, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27914185/use-of-peers-to-improve-adherence-to-antiretroviral-therapy-a-global-network-meta-analysis
#7
REVIEW
Steve Kanters, Jay Jh Park, Keith Chan, Nathan Ford, Jamie Forrest, Kristian Thorlund, Jean B Nachega, Edward J Mills
INTRODUCTION: It is unclear whether using peers can improve adherence to antiretroviral therapy (ART). To construct the World Health Organization's global guidance on adherence interventions, we conducted a systematic review and network meta-analysis to determine the effectiveness of using peers for achieving adequate adherence and viral suppression. METHODS: We searched for randomized clinical trials of peer-based interventions to promote adherence to ART in HIV populations...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27910966/stem-cell-and-regenerative-medicine-global-conference-scrgc-2016-august-23-24-2016-gyeonggi-do-korea
#8
A Vertès
In its third edition, the Stem Cell and Regenerative Medicine Global Conference (SCRGC) organized by the Global Stem Cell & Regenerative Medicine Acceleration Center (GSRAC) was focused on breaking barriers to accelerate the pace of innovation and development of the regenerative medicine industry. GSRAC is both a think tank and a global network of key opinion leaders from the public and the private sectors. GSRAC was commissioned in 2011 by the Ministry of Health and Welfare (MOHW) of Korea. GSRAC's primary mission is to enable and accelerate the delivery of innovative technologies to patients who are affected by currently untreatable diseases...
October 2016: Drugs of Today
https://www.readbyqxmd.com/read/27907898/obstetrical-and-perinatal-outcomes-following-blastocyst-transfer-compared-to-cleavage-transfer-a-systematic-review-and-meta-analysis
#9
W P Martins, C O Nastri, L Rienzi, S Z van der Poel, C R Gracia, C Racowsky
STUDY QUESTION: Is blastocyst transfer safe when compared to cleavage stage embryo transfer regarding obstetric and perinatal outcomes? SUMMARY ANSWER: The clinical equipoise between blastocyst and cleavage stage embryo transfer remains as the evidence associating blastocyst transfer with some adverse perinatal outcomes is of low/very low quality. WHAT IS KNOWN ALREADY: Extended embryo culture to the blastocyst stage provides some theoretical advantages and disadvantages...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27905941/financing-strategies-to-improve-essential-public-health-equalization-and-its-effects-in-china
#10
Li Yang, Li Sun, Liankui Wen, Huyang Zhang, Chenyang Li, Kara Hanson, Hai Fang
BACKGROUND: In 2009, China launched a health reform to promote the equalization of national essential public health services package (NEPHSP). The present study aimed to describe the financing strategies and mechanisms to improve access to public health for all, identify the strengths and weaknesses of the different approaches, and showed evidence on equity improvement among different regions. METHODS: We reviewed the relevant literatures and identified 208 articles after screening and quality assessment and conducted six key informants' interviews...
December 1, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27905017/an-evaluation-of-preparedness-delivery-and-impact-of-surgical-and-anesthesia-care-in-madagascar-a-framework-for-a-national-surgical-plan
#11
Emily Bruno, Michelle C White, Linden S Baxter, Vaonandianina Agnès Ravelojaona, Hasiniaina Narindria Rakotoarison, Hery Harimanitra Andriamanjato, Kristin L Close, Alison Herbert, Nakul Raykar, Saurabh Saluja, Mark G Shrime
BACKGROUND: The Lancet Commission on Global Surgery (LCoGS) described the lack of access to safe, affordable, timely surgical, and anesthesia care. It proposed a series of 6 indicators to measure surgery, accompanied by time-bound targets and a template for national surgical planning. To date, no sub-Saharan African country has completed and published a nationwide evaluation of its surgical system within this framework. METHOD: Mercy Ships, in partnership with Harvard Medical School and the Madagascar Ministry of Health, collected data on the 6 indicators from 22 referral hospitals in 16 out of 22 regions of Madagascar...
November 30, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27903517/branched-chain-fatty-acid-composition-of-human-milk-and-the-impact-of-maternal-diet-the-global-exploration-of-human-milk-gehm-study
#12
Kelly A Dingess, Christina J Valentine, Nicholas J Ollberding, Barbara S Davidson, Jessica G Woo, Suzanne Summer, Yongmei M Peng, M Lourdes Guerrero, Guillermo M Ruiz-Palacios, Rinat R Ran-Ressler, Robert J McMahon, J Thomas Brenna, Ardythe L Morrow
BACKGROUND: An understudied component of the diet, branched-chain fatty acids (BCFAs) are distinctive saturated fatty acids that may have an important influence on health. Human-milk fatty acid composition is known to differ worldwide, but comparative data are lacking on BCFAs. OBJECTIVE: We tested the hypotheses that concentrations of BCFAs in human milk differ between populations and are associated with maternal diet. DESIGN: We surveyed the BCFA composition of samples collected as part of a standardized, prospective study of human-milk composition...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27898022/enhanced-and-extended-anti-hypertensive-effect-of-vp5-nanoparticles
#13
Ting Yu, Shengnan Zhao, Ziqiang Li, Yi Wang, Bei Xu, Dailong Fang, Fazhan Wang, Zhi Zhang, Lili He, Xiangrong Song, Jian Yang
Hypertension has become a significant global public health concern and is also one of the most common risk factors of cardiovascular disease. Recent studies have shown the promising result of peptides inhibiting angiotensin converting enzyme (ACE) in lowering the blood pressure in both animal models and humans. However, the oral bioavailability and continuous antihypertensive effectiveness require further optimization. Novel nanoparticle-based drug delivery systems are helpful to overcome these barriers. Therefore, a poly-(lactic-co-glycolic) acid nanoparticle (PLGANPs) oral delivery system, of the antihypertensive small peptides Val-Leu-Pro-Val-Pro (VLPVP, VP5) model, was developed in this study and its antihypertensive effect was investigated in spontaneously hypertensive rats (SHRs) for the first time...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27890315/global-surgery-a-view-from-the-south
#14
REVIEW
Nobhojit Roy
: This article is based on the Hugh Greenwood Lecture delivered at the 2016 Congress of the British Association of Paediatric Surgeons. It presents the view of the global surgery movement from the bottom of the surgical food chain and proposes what HICs (high-income countries) can do for global surgery in a coordinated fashion. From the LMIC (low- and middle-income countries) surgeon perspective, global surgery is transitioning from the charity-based surgery model to codevelopment with multiple stakeholders...
November 12, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27884311/understanding-kidney-care-needs-and-implementation-strategies-in-low-and-middle-income-countries-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#15
Vivekanand Jha, Mustafa Arici, Allan J Collins, Guillermo Garcia-Garcia, Brenda R Hemmelgarn, Tazeen H Jafar, Roberto Pecoits-Filho, Laura Sola, Charles R Swanepoel, Irma Tchokhonelidze, Angela Yee Moon Wang, Bertram L Kasiske, David C Wheeler, Goce Spasovski
Evidence-based cinical practice guidelines improve delivery of uniform care to patients with and at risk of developing kidney disease, thereby reducing disease burden and improving outcomes. These guidelines are not well-integrated into care delivery systems in most low- and middle-income countries (LMICs). The KDIGO Controversies Conference on Implementation Strategies in LMIC reviewed the current state of knowledge in order to define a road map to improve the implementation of guideline-based kidney care in LMICs...
December 2016: Kidney International
https://www.readbyqxmd.com/read/27883944/allocative-and-implementation-efficiency-in-hiv-prevention-and-treatment-for-people-who-inject-drugs
#16
Clemens Benedikt, Sherrie L Kelly, David Wilson, David P Wilson
BACKGROUND: Estimated global new HIV infections among people who inject drugs (PWID) remained stable over the 2010-2015 period and the target of a 50% reduction over this period was missed. To achieve the 2020 UNAIDS target of reducing adult HIV infections by 75% compared to 2010, accelerated action in scaling up HIV programs for PWID is required. In a context of diminishing external support to HIV programs in countries where most HIV-affected PWID live, it is essential that available resources are allocated and used as efficiently as possible...
November 21, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27882748/-application-of-the-concetrations-ratio-of-soluble-receptor-tyrosine-kinase-type-1-and-placental-growth-factor-for-short-term-prediction-and-diagnosis-of-preeclampsia
#17
Š Bubeníková, A Cíchová, L Roubalová, V Durdová, R Vlk
OBJECTIVE: Bring a comprehensive overview of the available information about applications of the concetration ratio of soluble receptor tyrosine kinase type 1 (sFlt-1), and placental growth factor for short-term prediction and diagnosis of preeclampsia. DESIGN: Overview study. SETTINGS: Department of Midwifery, Faculty of Health Sciences, Olomouc; Department of Clinical Biochemistry, University Hospital Olomouc; Department of Obstetrics and Gynecology, University Hospital Olomouc; Department of Obstetrics and Gynecology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27881192/effect-of-a-ceiling-fan-ventilation-system-on-finishing-young-bulls-health-behaviour-and-growth-performance
#18
L Magrin, M Brscic, I Lora, C Rumor, L Tondello, G Cozzi, F Gottardo
This research aimed at assessing the effects of a ceiling fan ventilation system on health, feeding, social behaviour and growth response of finishing young bulls fattened indoors during a mild summer season. A total of 69 Charolais young bulls were housed in six pens without any mechanical ventilation system (Control) and in six pens equipped with ceiling fans. The experimental period lasted 98 days from June until mid-September 2014. Four experimental days were considered in order to assess the effect of the ventilation system under two different microclimatic conditions: 2 alert days at monthly interval with temperature humidity index (THI) between 75 and 78, and 2 normal days with THI⩽74...
November 24, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27871185/interventions-that-increase-the-intention-to-seek-voluntary-hiv-testing-in-young-people-a-review
#19
Kelly Feist Bumgarner, Jennifer Pharr, Mark Buttner, Echezona Ezeanolue
Young people 15-24 years old represent 39% of new HIV infections globally. However, they are the least likely age demographic to seek HIV testing and the most likely to be unaware of their HIV status. The purpose of this systematic literature review was to identify interventions that increase either rates of HIV testing or intentions to seek HIV testing in young people 10-24 years old. In total, 1601 manuscripts were systematically examined and five manuscripts were included in the final review. Two common themes identified in the interventions were education and test delivery methods...
November 22, 2016: AIDS Care
https://www.readbyqxmd.com/read/27852239/determinants-of-use-of-health-facility-for-childbirth-in-rural-hadiya-zone-southern-ethiopia
#20
Netsanet Abera Asseffa, Fawole Bukola, Arowojolu Ayodele
BACKGROUND: Maternal mortality remains a major global public health concern despite many international efforts. Facility-based childbirth increases access to appropriate skilled attendance and emergency obstetric care services as the vast majority of obstetric complications occur during delivery. The purpose of the study was to determine the proportion of facility delivery and assess factors influencing utilization of health facility for childbirth. METHODS: A cross-sectional study was conducted in two rural districts of Hadiya zone, southern Ethiopia...
November 16, 2016: BMC Pregnancy and Childbirth
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