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Sero negative rheumatoid arthritis

Klara Morsley, Anne Miller, Raashid Luqmani, Francesc Fina-Aviles, Muhammad Kassim Javaid, Christopher J Edwards, Rafael Pinedo-Villanueva, Manuel Medina, Sebastian Calero, Cyrus Cooper, Nigel Arden, Daniel Prieto-Alhambra
OBJECTIVE: Rheumatoid factor (RF) testing is used in primary care in the diagnosis of rheumatoid arthritis (RA); however a positive RF may occur without RA. Incorrect use of RF testing may lead to increased costs and delayed diagnoses. The aim was to assess the performance of RF as a test for RA and to estimate the costs associated with its use in a primary care setting. MATERIAL AND METHODS: A retrospective cohort study using the Information System for the Development of Research in Primary Care database (contains primary care records and laboratory results of >80% of the Catalonian population, Spain)...
February 26, 2018: Reumatología Clinica
Marie-Elise Truchetet, Stéphanie Dublanc, Thomas Barnetche, Olivier Vittecoq, Xavier Mariette, Christophe Richez, Patrick Blanco, Michael Mahler, Cécile Contin-Bordes, Thierry Schaeverbeke
OBJECTIVE: To assess the prevalence of anti-carbamylated protein (anti-CarP) antibodies in a French cohort of patients with early arthritis and to investigate their association with clinical features, final diagnosis, prognosis, and comorbidities. METHODS: The presence of anti-CarP antibodies among patients with early arthritis in the French Etude et Suivi des Polyarthrites Indifférenciées Récentes (ESPOIR) cohort (n = 720) was determined using enzyme-linked immunosorbent assay...
December 2017: Arthritis & Rheumatology
Wen-Hua Wei, Sebastien Viatte, Tony R Merriman, Anne Barton, Jane Worthington
Sero-negative rheumatoid arthritis (RA) is a highly heterogeneous disorder with only a few additive loci identified to date. We report a genotypic variability-based genome-wide association study (vGWAS) of six cohorts of sero-negative RA recruited in Europe and the US that were genotyped with the Immunochip. A two-stage approach was used: (1) a mixed model to partition dichotomous phenotypes into an additive component and non-additive residuals on the liability scale and (2) the Levene's test to assess equality of the residual variances across genotype groups...
July 13, 2017: Scientific Reports
Jian Feng, Qi Chen, Feifei Yu, Zhiyong Wang, Shuqi Chen, Zhichao Jin, Qing Cai, Yu Liu, Jia He
Although many epidemiological studies have investigated the association between body mass index (BMI) and risk of rheumatoid (RA), the results have been inconsistent. Therefore, we performed a dose-response meta-analysis to quantify the dose-response association between BMI and RA risk.We systematically searched PubMed, Embase, and Web of Science databases and reference lists of articles for relevant studies published before August 2014 using terms related to BMI and RA. Fixed or random-effects models were used to estimate the pooled relative risk (RR) with 95% confidence interval (CI)...
February 2016: Medicine (Baltimore)
Anthony Alozie, Annette Zimpfer, Kerstin Köller, Bernd Westphal, Annette Obliers, Andreas Erbersdobler, Gustav Steinhoff, Andreas Podbielski
BACKGROUND: Whipple's disease is a rare, often multisystemic chronic infectious disease caused by the rod-shaped bacterium Tropheryma whipplei. Very rarely the heart is involved in the process of the disease, leading to culture-negative infective endocarditis. Up to 20 % of all infective endocarditis are blood culture-negative and therefore a diagnostic challenge. We present two unusual cases of culture-negative infective endocarditis encountered in two different patients with prior history of arthralgia...
2015: BMC Infectious Diseases
Ko-Ming Lin, Tien-Tsai Cheng, Jing-Chi Lin, Chung-Jen Chen
The aim of this study was to investigate treatment response and hepatic safety of anti-tumor necrosis factor-α therapy among patients with concomitant rheumatoid arthritis (RA) and hepatitis C virus (HCV) infection. We reviewed the charts of 101 consecutive RA patients who were eligible for anti-TNF-α therapy in the Chiayi Branch of Chang Gung Memorial Hospital. Group A patients were sero-positive for anti-HCV antibodies and had HCV RNA but were negative for hepatitis B surface antigen (HBsAg). Group B (the control group) patients were sero-negative for both anti-HCV antibodies and HBsAg...
June 2015: Clinical Rheumatology
Magdalena J Laska, Bettina Hansen, Anne Troldborg, Tove Lorenzen, Kristian Stengaard-Pedersen, Peter Junker, Bjørn A Nexø, Hanne M Lindegaard
BACKGROUND: It has been suggested that polymorphisms in Toll-like Receptors (TLRs) are associated with Rheumatoid Arthritis (RA), but the implicated alleles have differed between studies. The aim of this investigation was to explore whether polymorphisms of TLR genes are associated with RA in a predominantly Caucasian population from Denmark using a case-control approach. FINDINGS: DNA samples (3 university hospital outpatient clinics) were obtained from patients with RA (n = 704) and healthy controls (n = 639) in a Danish population...
2014: BMC Research Notes
L Khondker, S I Khan
Psoriatic arthritis is a condition that causes inflammation of the joints of psoriatic patients. Psoriatic arthritis also affects tissues surrounding the joints including tendon and ligaments. Psoriatic arthritis (PsA), recognized for over 100 years, is the second most frequent diagnostic category after Rhematoid Arthritis (RA) and occurring up to 10% of patients with skin psoriasis. Although PsA is a sero-negative arthritis and the absence of rheumatoid factor is a characteristic laboratory finding, it may be present in 3% of psoriatic arthritis (PsA) patients...
July 2014: Mymensingh Medical Journal: MMJ
Anca Macri, Ruxandra Ulmeanu, Florin Mihălţan, Gabriela Popa, Radu Stoica
The authors present the case of a 53-year-old female, initially admitted in a rheumatology department for fever and diffuse arthritis--being diagnosed with sero-positive rheumathoid arthritis. Although the chest X-ray and CT scan of thorax showed several abnormal features (medium lobe atelectasis, pseudo-cyst in the posterior segment of the right upper lobe with satellite milliary nodules, mediastinal lymph node enlargement), the investigations performed in our pneumology department couldn't establish the etiology of radiological abnormalities...
January 2014: Pneumologia: Revista Societății Române de Pneumologie
Narisa Sulaiman Sahari, Syahrul Sazliyana Shaharir, Mohd Redzuan Ismail, Sakthiswary Rajalingham, Mohd Shahrir Mohamed Said
OBJECTIVE: To determine the associated factors of subclinical atherosclerosis measured with carotid intima media thickness (CIMT) among rheumatoid arthritis (RA) patients without any overt traditional cardiovascular (CV) risk factors. METHODS: Forty RA patients with matched age and gender healthy controls were recruited. Carotid ultrasound was performed to all subjects. CIMT was considered to be abnormally thickened if it was more than the 75th percentile matched for age and sex reference values...
November 2014: Modern Rheumatology
Vjollca Sahatçiu-Meka, Sylejman Rexhepi, Anton Kukeli, Suzana Manxhuka-Kërliu, Kelmend Pallaskas, Ardiana Murtezani, Mjellma Rexhepi, Blerta Rexhepi
Long since it have been suggested that a subpopulation of patients with rheumatoid arthritis (RA), diagnosed with negative rheumatoid factor (RF) tests, represents a clinical entity quite distinct from that of seropositive rheumatoid arthritis. The aim of the study was to establish a scientific comparative analysis between RA seronegative and seropositive, regarding course and prognoses of the disease. Two hundred fifty patients with rheumatoid arthritis according to the (American College of Rheumatology) criteria were retrospectively studied by analysis the course and prognoses of disease...
2013: Reumatizam
Salvador de la Torre Carazo, Olga Tourin, Daniel Smith, Fischer Aryeh
SESSION TYPE: Miscellaneous Case Report Posters IIPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Lung disease occurs commonly in rheumatoid arthritis (RA) and is associated with significant morbidity and mortality. Recently, Fischer and colleagues demonstrated that anti-cyclic citrullinated peptide (anti-CCP) positive individuals with airways or interstitial lung disease may represent a "pre-articular" RA phenotype.CASE PRESENTATION: A 61-year-old Caucasian man, with a 7.5 pack-year smoking history, seasonal allergies, gastroesophageal reflux disease, obstructive sleep apnea, and dyslipidemia presented with pleuritic chest pain and dry cough of five months duration...
October 1, 2012: Chest
Yan Geng, Zhuo-li Zhang
AIM: To investigate the differences of B lymphocyte stimulator (BlyS) level and frequency of lymphocytes between sero-negative and sero-positive rheumatoid arthritis (RA) patients. METHODS: Sixty-nine RA patients were enrolled into this study and their clinical data were recorded. The BlyS levels in plasma, frequency of T and B lymphocytes, as well as T-helper (Th) subgroups were compared between sero-negative and sero-positive RA patients. Furthermore, the correlations between clinical features and immunological features were analyzed...
October 2012: International Journal of Rheumatic Diseases
L Rebekka Ryder, Else Marie Bartels, Anders Woetmann, Hans Ole Madsen, Niels Odum, Henning Bliddal, Bente Danneskiold-Samsøe, Søren Ribel-Madsen, Lars P Ryder
Our aim was to elucidate the relative amount of the different splice forms of FoxP3 mRNA in CD4+ T cells in peripheral blood (PB) compared to synovial fluid (SF) in RA and PsA patients. FoxP3 mRNA was measured using a quantitative real-time PCR method. CD4+ T cells were isolated from 17 paired samples of PB and SF from RA and PsA patients, and PB from 10 controls. FoxP3fl and FoxP3Δ2 mRNA was significantly increased (6.7 and 2.1-fold, respectively) in PB CD4+ T cells from RA patients compared to controls. FoxP3fl and Δ2 mRNA in SF CD4+ T cells was increased compared to controls in sero-negative RA and PsA, but not in sero-positive RA patients, who had a high FoxP3 expression in both PB and SF...
May 2012: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
S Mitsunaga, Y Suzuki, M Kuwana, S Sato, Y Kaneko, Y Homma, A Narita, K Kashiwase, Y Okudaira, I Inoue, J K Kulski, H Inoko
Although the HLA region contributes to one-third of the genetic factors affecting rheumatoid arthritis (RA), there are few reports on the association of the disease with any of the HLA loci other than the DRB1. In this study we examined the association between RA and the alleles of the six classical HLA loci including DRB1. Six HLA loci (HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1) of 1659 Japanese subjects (622 cases; 488 anti-cyclic citrullinated peptides (CCP) antibody (Ab) positive (82.6%); 103 anti-CCP Ab negative (17...
July 2012: Tissue Antigens
Yan Geng, Wei Zhou, Zhuo-Li Zhang
To investigate the similarities and differences in clinical features between the sero-negative and sero-positive rheumatoid arthritis (RA) patients. Two hundred and sixty-two RA patients who fulfilled the 1987 ACR RA Classification Criteria were enrolled into this study. They were divided into sero-negative and sero-positive group depending on the presence or absence of rheumatoid factor (RF) and anti-cyclic citrullinate peptide (anti-CCP). The clinical features were compared between these two groups. Forty-six (17...
December 2012: Rheumatology International
Karthikeyan Iyengar, Tharjan Manickavasagar, Jayant Nadkarni, Paul Mansour, William Loh
INTRODUCTION: Rice body formation has been traditionally observed in the joint and tendon sheaths of patients with tuberculosis. Few case reports exist that describe rice body formation in patients with rheumatoid arthritis. We describe a case report of bilateral recurrent wrist flexor tenosynovitis with rice body formation in a patient with sero-negative rheumatoid arthritis. PRESENTATION OF CASE: This case report describes a 72 year old lady presenting with severe bilateral, flexor tenosynovitis of the wrists...
2011: International Journal of Surgery Case Reports
Vjollca Sahatçiu-Meka, Sylejman Rexhepi, Suzana Manxhuka-Kërliu, Mjellma Rexhepi
Long since it have been suggested that a subpopulation of patients with rheumatoid arthritis, diagnosed with negative rheumatoid factor tests, represents a clinical entity quite distinct from that of seropositive rheumatoid arthritis (RA). Our aim was to establish a scientific comparative analysis between seronegative and seropositive rheumatoid arthritis, regarding some radiological and clinical parameters, applied for the first time on patients from Kosovo. Two hundred fifty patients with rheumatoid arthritis according to the American College of Rheumatology criteria were retrospectively studied by analysis the radiographic damage and clinical parameters of the disease, using a data base...
August 2011: Bosnian Journal of Basic Medical Sciences
Moshe Tishler, Oleg Lysyy, Ofer Levy, Olga Volkov, Haim Golan
OBJECTIVES: To make a comparison between the clinical data and the imaging results with 99mTc-nanocolloid scintigraphy in rheumatoid arthritis (RA) patients considered to be in remission. METHODS: Forty RA patients found to be in clinical remission according to the ACR and the EULAR (DAS28<2.6) criteria were studied. The group included 29 females and 11 males with a mean age of 60.8+/-13.5 years (range 22-86) and a mean disease duration of 13.4+/-7.7 years (range 2-23)...
May 2010: Clinical and Experimental Rheumatology
M V Larsen, I J Sørensen, V Ø Thomsen, P Ravn
Treatment with tumour necrosis factor-alpha inhibitors increases the risk of tuberculosis (TB). Screening for latent TB infection (LTBI) and prophylactic treatment has become mandatory. A 79-yr-old female with a history of severe erosive sero-positive rheumatoid arthritis was screened for LTBI before initiation of treatment with infliximab. The tuberculin skin test (TST) was negative, chest radiography was normal and she had no known risk factors for TB. After 4 months of treatment with infliximab, the patient developed ascites caused by Mycobacterium bovis...
July 2008: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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