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J M C Winhammar, D Joffe, R Simmul, R Schoeffel, M C Kiernan, D B Rowe
BACKGROUND: With increasing awareness of motor neuron disease (MND) in Australia, the approach to respiratory management of patients with this disease will more commonly face the respiratory physician. AIM: The aim of this study was to determine if standard respiratory function tests could determine the presence of nocturnal hypoxia (NH) in patients with MND. METHODS: Respiratory function tests were used to examine daytime respiratory function, and sleep studies were used to detect NH in 16 consecutive patients with MND and in 9 healthy control subjects...
July 2006: Internal Medicine Journal
Patricia Buendia, Giri Narasimhan
A new computational method to study within-host viral evolution is explored to better understand the evolution and pathogenesis of viruses. Traditional phylogenetic tree methods are better suited to study relationships between contemporaneous species, which appear as leaves of a phylogenetic tree. However, viral sequences are often sampled serially from a single host. Consequently, data may be available at the leaves as well as the internal nodes of a phylogenetic tree. Recombination may further complicate the analysis...
2004: Proceedings
No abstract text is available yet for this article.
September 19, 1964: Medical Journal of Australia
M A McClean, P I Field, M J Matheson, R Simmul, N Berend
Airway inflammation can be studied by obtaining sputum induced by inhalation of 3% saline. The Sensormedics MCT accelerator is an oral asymmetrical high frequency oscillator which safely enhances clearance of airway secretions. The aim of this study was to determine if use of the MCT Accelerator enhances sputum production in non-asthmatic non-atopic, atopic and asthmatic subjects. Fifteen subjects were studied over 3 days. On day 1 skin prick testing to common aeroallergens and methacholine bronchial reactivity were performed...
December 1996: Respirology: Official Journal of the Asian Pacific Society of Respirology
C L Phillips, R Simmul, A I Smith, N Berend
One hour after a bone marrow biopsy and inhalation of Entonox gas (50% nitrous oxide (N2O) and 50% oxygen), a patient had a markedly reduced transfer factor of the lung for carbon monoxide (TL,CO). Three hours after Entonox, the patient had a normal TL,CO. Since carbon monoxide (CO) and N2O have similar spectral wavelengths, it was proposed that residual N2O in the lungs was interfering with the infra-red analysers used to detect CO concentrations. Experiments were performed to verify the "interference" effect and its duration...
January 1997: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
P I Field, R Simmul, S C Bell, D H Allen, N Berend
BACKGROUND: Inhalation of sulphur dioxide (SO2) provokes bronchoconstriction in asthmatic subjects. Cholinergic mechanisms contribute, but other mechanisms remain undefined. The effect of morphine, an opioid agonist, on the cholinergic component of SO2-induced bronchoconstriction was investigated, and the effect of indomethacin, a cyclooxygenase inhibitor, on SO2-induced bronchoconstriction and tachyphylaxis was studied. METHODS: In the first study 16 asthmatic subjects inhaled either ipratropium bromide or placebo 60 minutes before an SO2 challenge on days 1 and 2...
February 1996: Thorax
P I Field, M McClean, R Simmul, N Berend
BACKGROUND: In asthmatic subjects bronchoconstriction is induced by inhalation of the common food preservatives sulphur dioxide (SO2) and metabisulphite (MBS). SO2 and MBS challenges share many similarities, but it is not known whether they are equivalent. In this study of subjects with mild clinical asthma equivalence was assessed by comparing SO2 and MBS reactivity by estimating the total dose of SO2 inhaled during SO2 and MBS challenges, and by calculating SO2 uptake during both challenges...
March 1994: Thorax
J Delohery, R Simmul, W D Castle, D H Allen
When ingested in acid solution, the preservative sodium metabisulfite (MB) provokes asthma within minutes of ingestion in a proportion of asthmatic subjects. Freshly prepared acid solutions of MB liberate significant quantities of gaseous SO2. In order to test the hypothesis that asthma provoked by ingestion of acidified solutions of MB was due to supersensitivity to SO2 inhaled during swallowing, 3 groups of 10 subjects were studied. Groups 1 and 2 were asthmatics. Group 1 subjects were reactors and Group 2 were nonreactors to ingested MB...
December 1984: American Review of Respiratory Disease
T A Freitag, S L Cannon
The vital first phase of the overall materials study to protract the life of the total joint replacements is the identification of the fracture toughness and fatigue properties of bone cements. Information gained from fatigue testing, performed in a manner which simmulates in vivo conditions, and fracture toughness, which is a measure of the propensity of a crack to propagate, is the first step towards the prediction of the life of the total joint replacement. This study is concerned with the fracture toughness of Zimmer and Simplex-P cold-curing bone cements...
September 1976: Journal of Biomedical Materials Research
B Hory, Y Saint-Hillier, J L Dupond, G Pageaut, C Billerey, G Coulon
No abstract text is available yet for this article.
June 18, 1977: La Nouvelle Presse M├ędicale
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