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https://www.readbyqxmd.com/read/28239639/alzheimer-s-biomarkers-in-daily-practice-abide-project-rationale-and-design
#1
Arno de Wilde, Ingrid S van Maurik, Marleen Kunneman, Femke Bouwman, Marissa Zwan, Eline A J Willemse, Geert Jan Biessels, Mirella Minkman, Ruth Pel, Niki S M Schoonenboom, Ellen M A Smets, Mike P Wattjes, Frederik Barkhof, Andrew Stephens, Erik J van Lier, Richard Batrla-Utermann, Philip Scheltens, Charlotte E Teunissen, Bart N M van Berckel, Wiesje M van der Flier
INTRODUCTION: The Alzheimer's biomarkers in daily practice (ABIDE) project is designed to translate knowledge on diagnostic tests (magnetic resonance imaging [MRI], cerebrospinal fluid [CSF], and amyloid positron emission tomography [PET]) to daily clinical practice with a focus on mild cognitive impairment (MCI). METHODS: ABIDE is a 3-year project with a multifaceted design and is structured into interconnected substudies using both quantitative and qualitative research methods...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28239607/how-to-face-chronic-liver-disease-the-sinusoidal-perspective
#2
REVIEW
Anabel Fernández-Iglesias, Jordi Gracia-Sancho
Liver microcirculation plays an essential role in the progression and aggravation of chronic liver disease. Hepatic sinusoid environment, mainly composed by hepatocytes, liver sinusoidal endothelial cells, Kupffer cells, and hepatic stellate cells, intimately cooperate to maintain global liver function and specific phenotype of each cell type. However, continuous liver injury significantly deregulates liver cells protective phenotype, leading to parenchymal and non-parenchymal dysfunction. Recent data have enlightened the molecular processes that mediate hepatic microcirculatory injury, and consequently, opened the possibility to develop new therapeutic strategies to ameliorate liver circulation and viability...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28239551/genome-wide-chromatin-accessibility-dna-methylation-and-gene-expression-analysis-of-histone-deacetylase-inhibition-in-triple-negative-breast-cancer
#3
Matias A Bustos, Matthew P Salomon, Nellie Nelson, Sandy C Hsu, Maggie L DiNome, Dave S B Hoon, Diego M Marzese
Triple-negative breast cancer (TNBC), especially the subset with a basal phenotype, represents the most aggressive subtype of breast cancer. Unlike other solid tumors, TNBCs harbor a low number of driver mutations. Conversely, we and others have demonstrated a significant impact of epigenetic alterations, including DNA methylation and histone post-translational modifications, affecting TNBCs. Due to the promising results in pre-clinical studies, histone deacetylase inhibitors (HDACi) are currently being tested in several clinical trials for breast cancer and other solid tumors...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28238999/race-genomics-and-chronic-disease-what-patients-with-african-ancestry-have-to-say
#4
Carol R Horowitz, Kadija Ferryman, Rennie Negron, Tatiana Sabin, Mayra Rodriguez, Randi F Zinberg, Erwin Böttinger, Mimsie Robinson
BACKGROUND: Variants of the APOL1 gene increase risk for kidney failure 10-fold, and are nearly exclusively found in people with African ancestry. To translate genomic discoveries into practice, we gathered information about effects and challenges incorporating genetic risk in clinical care. METHODS: An academic-community-clinical team tested 26 adults with self-reported African ancestry for APOL1 variants, conducting in-depth interviews about patients' beliefs and attitudes toward genetic testing- before, immediately, and 30 days after receiving test results...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28238726/ex-vivo-lung-perfusion-a-key-tool-for-translational-science-in-the-lungs
#5
Shinya Tane, Kentaro Noda, Norihisa Shigemura
Ex vivo lung perfusion (EVLP) promises to be a comprehensive platform for assessment, re-conditioning, and preservation for donor lungs and has been dramatically changing the face of clinical lung transplantation. Besides its increasing role in lung transplantation, EVLP has also been recognized as a useful tool for translational research involving the lungs. Based on recent remarkable evidence and experience using EVLP in lung transplantation, there is growing interest in and expectations for the use of EVLP beyond the field of lung transplantation...
February 23, 2017: Chest
https://www.readbyqxmd.com/read/28238146/air-liquid-interface-cell-exposures-to-nanoparticle-aerosols
#6
Nastassja A Lewinski, Nathan J Liu, Akrivi Asimakopoulou, Eleni Papaioannou, Athanasios Konstandopoulos, Michael Riediker
The field of nanomedicine is steadily growing and several nanomedicines are currently approved for clinical use with even more in the pipeline. Yet, while the use of nanotechnology to improve targeted drug delivery to the lungs has received some attention, the use of nanoparticles for inhalation drug delivery has not yet resulted in successful translation to market as compared to intravenous drug delivery. The reasons behind the lack of inhaled nanomedicines approved for clinical use or under preclinical development are unclear, but challenges related to safety are likely to contribute...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28238076/delta-opioid-receptors-and-cardioprotection
#7
Louise See Hoe, Hemal H Patel, Jason N Peart
The opioid receptor family, with associated endogenous ligands, has numerous roles throughout the body. Moreover, the delta opioid receptor (DORs) has various integrated roles within the physiological systems, including the cardiovascular system. While DORs are important modulators of cardiovascular autonomic balance, they are well-established contributors to cardioprotective mechanisms. Both endogenous and exogenous opioids acting upon DORs have roles in myocardial hibernation and protection against ischaemia-reperfusion (I-R) injury...
February 26, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28237513/unraveling-the-role-of-er-stress-inhibitors-in-the-context-of-metabolic-diseases
#8
REVIEW
Chodisetty Sarvani, Dornadula Sireesh, Kunka Mohanram Ramkumar
ER stress is provoked by the accumulation of unfolded and misfolded proteins in the ER lumen leading to perturbations in ER homeostasis. ER stress activates a signaling cascade called the Unfolded Protein Response (UPR) which triggers a set of transcriptional and translational events that restore ER homeostasis, promoting cell survival and adaptation. If this adaptive response fails, a terminal UPR program commits such cells to apoptosis. Existing preclinical and clinical evidence testify that prolonged ER stress escalates the risk of several metabolic disorders including diabetes, obesity and dyslipidemia...
February 22, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28237437/disease-impact-on-general-well-being-and-therapeutic-expectations-of-european-type-ii-and-type-iii-spinal-muscular-atrophy-patients
#9
Françoise Rouault, Vanessa Christie-Brown, Ria Broekgaarden, Nicole Gusset, Doug Henderson, Patryk Marczuk, Inge Schwersenz, Gil Bellis, Christian Cottet
Spinal muscular atrophy (SMA) is a neurodegenerative disorder showing a broad clinical spectrum and no cure to date. To design and select evaluation criteria for the potential assessment of drugs currently being developed, the patient's perspective is critical. A survey, aiming to obtain a view on the current clinical state of European Type II and Type III SMA patients, the impact of this situation on their quality of life and their expectations regarding clinical development, was carried out by SMA-Europe member organizations in July 2015...
February 3, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28237313/peripheral-administration-of-the-soluble-tnf-inhibitor-xpro1595-modifies-brain-immune-cell-profiles-decreases-beta-amyloid-plaque-load-and-rescues-impaired-long-term-potentiation-in-5xfad-mice
#10
Kathryn P MacPherson, Pradoldej Sompol, George T Kannarkat, Jianjun Chang, Lindsey Sniffen, Mary E Wildner, Christopher M Norris, Malú G Tansey
: Clinical and animal model studies have implicated inflammation and peripheral immune cell responses in the pathophysiology of Alzheimer's disease (AD). Peripheral immune cells including T cells circulate in the cerebrospinal fluid (CSF) of healthy adults and are found in the brains of AD patients and AD rodent models. Blocking entry of peripheral macrophages into the CNS was reported to increase amyloid burden in an AD mouse model. To assess inflammation in the 5xFAD (Tg) mouse model, we first quantified central and immune cell profiles in the deep cervical lymph nodes and spleen...
February 22, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28236988/-what-can-we-expect-from-clinical-trials-in-psychiatry
#11
A Marsot, Q Boucherie, F Kheloufi, C Riff, D Braunstein, J Dupouey, R Guilhaumou, X Zendjidjian, S Bonin-Guillaume, E Fakra, M Guye, V Jirsa, J-M Azorin, R Belzeaux, M Adida, J Micallef, O Blin
Clinical trials in psychiatry allow to build the regulatory dossiers for market authorization but also to document the mechanism of action of new drugs, to build pharmacodynamics models, evaluate the treatment effects, propose prognosis, efficacy or tolerability biomarkers and altogether to assess the impact of drugs for patient, caregiver and society. However, clinical trials have shown some limitations. Number of recent dossiers failed to convince the regulators. The clinical and biological heterogeneity of psychiatric disorders, the pharmacokinetic and pharmacodynamics properties of the compounds, the lack of translatable biomarkers possibly explain these difficulties...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/28236726/the-influence-of-epilepsy-on-children-s-perception-of-self-concept
#12
Flora Lopes Scatolini, Karina Piccin Zanni, Luzia Iara Pfeifer
The diagnosis of epilepsy can lead to changes in the patient's perception due to factors such as learning and behavioral problems, lack of academic motivation, and low self-esteem. This study aimed to evaluate and compare the knowledge of self-concept in children with epilepsy and those with typical development and verify whether gender and age influence this perception. Eighty children of both sexes, aged between 8 and 14years, participated in this study. The children were divided into two groups: the epilepsy group, which consisted of 40 children diagnosed with epilepsy, and the control group, which consisted of 40 children with typical development and comparable to group 1 according to sex and age...
February 22, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28236701/an-alternative-poldip3-transcript-promotes-hepatocellular-carcinoma-progression
#13
Xiao-Ning Liu, Ji-Hang Yuan, Tian-Tian Wang, Wei Pan, Shu-Han Sun
Alternative splicing plays critical roles in many pathophysiological processes and splicing dysregulation is a hallmark of cancer. The different isoforms may have significantly different effects on cancers. POLDIP3 is a target of ribosomal protein S6 kinase 1, and regulates DNA replication and mRNA translation. In this study, we measured the expression of an alternative POLDIP3 transcript (POLDIP3-β), which lacks exon 3 and 29 amine acids, in clinical hepatocellular carcinoma (HCC) tissues. The roles of POLDIP3-β on HCC cell proliferation, apoptosis, and migration were assessed by Glo cell viability assays, Ethynyl deoxyuridine incorporation assays, colony formation assays, TUNEL assays, Annexin V-propidium iodide staining and flow cytometry, transwell assays, wound healing assays, and in vivo xenograft growth...
February 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28236692/synthesis-and-characterization-of-folate-decorated-albumin-bio-conjugate-nanoparticles-loaded-with-a-synthetic-curcumin-difluorinated-analogue
#14
Kaustubh A Gawde, Prashant Kesharwani, Samaresh Sau, Fazlul H Sarkar, Subhash Padhye, Sushil K Kashaw, Arun K Iyer
Albumin-bound paclitaxel colloidal nanoparticle (Abraxane®) is an FDA approved anticancer formulation available in the market. It is a suspension which is currently used therapeutically for treating cancers of the breast, lung, and pancreas among others. CDF is a novel new and potent synthetic curcumin analogue that is widely used for breast and ovarian cancer. The aim of this study was to use biocompatible albumin as well as folate decorated albumin to formulate colloidal nanoparticles encapsulating curcumin difluorinated (CDF)...
February 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28236285/cardiovascular-effects-of-stimulant-and-non-stimulant-medication-for-children-and-adolescents-with-adhd-a-systematic-review-and-meta-analysis-of-trials-of-methylphenidate-amphetamines-and-atomoxetine
#15
REVIEW
Leonie Hennissen, Mireille J Bakker, Tobias Banaschewski, Sara Carucci, David Coghill, Marina Danckaerts, Ralf W Dittmann, Chris Hollis, Hanna Kovshoff, Suzanne McCarthy, Peter Nagy, Edmund Sonuga-Barke, Ian C K Wong, Alessandro Zuddas, Eric Rosenthal, Jan K Buitelaar
BACKGROUND: Many children and adolescents with attention deficit/hyperactivity disorder (ADHD) are treated with stimulant and non-stimulant medication. ADHD medication may be associated with cardiovascular effects. It is important to identify whether mean group effects translate into clinically relevant increases for some individual patients, and/or increase the risk for serious cardiovascular adverse events such as stroke or sudden death. OBJECTIVES: To evaluate potential cardiovascular effects of these treatments, we conducted a systematic review and meta-analysis of the effects of methylphenidate (MPH), amphetamines (AMP), and atomoxetine (ATX) on diastolic and systolic blood pressure (DBP, SBP) and heart rate (HR) in children and adolescents with ADHD...
February 24, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28236227/development-of-18-f-dasa-23-for-imaging-tumor-glycolysis-through-noninvasive-measurement-of-pyruvate-kinase-m2
#16
Corinne Beinat, Israt S Alam, Michelle L James, Ananth Srinivasan, Sanjiv Sam Gambhir
PURPOSE: A hallmark of cancer is metabolic reprogramming, which is exploited by cancer cells to ensure rapid growth and survival. Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key step in tumor metabolism and growth. Recently, we reported the radiosynthesis of the first positron emission tomography tracer for visualizing PKM2 in vivo-i.e., [(11)C]DASA-23. Due to the highly promising imaging results obtained with [(11)C]DASA-23 in rodent model glioblastoma, we set out to generate an F-18-labeled version of this tracer, with the end goal of clinical translation in mind...
February 24, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28236105/selection-and-prioritization-of-candidate-drug-targets-for-amyotrophic-lateral-sclerosis-through-a-meta-analysis-approach
#17
Giovanna Morello, Antonio Gianmaria Spampinato, Francesca Luisa Conforti, Velia D'Agata, Sebastiano Cavallaro
Amyotrophic lateral sclerosis (ALS) is a progressive and incurable neurodegenerative disease. Although several compounds have shown promising results in preclinical studies, their translation into clinical trials has failed. This clinical failure is likely due to the inadequacy of the animal models that do not sufficiently reflect the human disease. Therefore, it is important to optimize drug target selection by identifying those that overlap in human and mouse pathology. We have recently characterized the transcriptional profiles of motor cortex samples from sporadic ALS (SALS) patients and differentiated these into two subgroups based on differentially expressed genes, which encode 70 potential therapeutic targets...
February 24, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28235977/use-of-concomitant-inhaled-corticosteroids-pooled-data-from-two-phase-iii-studies-of-aclidinium-plus-formoterol-in-copd
#18
Anthony D'Urzo, Dave Singh, Esther Garcia Gil
Bronchodilator therapy is the backbone of the management of chronic obstructive pulmonary disease. In some patients, inhaled corticosteroids can be prescribed in combination with bronchodilators. Through a subgroup analysis of pooled data from two large phase III clinical trials of bronchodilator therapy according to concomitant inhaled corticosteroid use (user vs. non-user), we sought to evaluate the clinical benefit of adding inhaled corticosteroids to dual bronchodilator therapy in chronic obstructive pulmonary disease...
December 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28235750/the-state-of-open-source-electronic-health-record-projects-a-software-anthropology-study
#19
Mona Alsaffar, Peter Yellowlees, Alberto Odor, Michael Hogarth
BACKGROUND: Electronic health records (EHR) are a key tool in managing and storing patients' information. Currently, there are over 50 open source EHR systems available. Functionality and usability are important factors for determining the success of any system. These factors are often a direct reflection of the domain knowledge and developers' motivations. However, few published studies have focused on the characteristics of free and open source software (F/OSS) EHR systems and none to date have discussed the motivation, knowledge background, and demographic characteristics of the developers involved in open source EHR projects...
February 24, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28235749/analysis-of-patient-narratives-in-disease-blogs-on-the-internet-an-exploratory-study-of-social-pharmacovigilance
#20
Shinichi Matsuda, Kotonari Aoki, Shiho Tomizawa, Masayoshi Sone, Riwa Tanaka, Hiroshi Kuriki, Yoichiro Takahashi
BACKGROUND: Although several reports have suggested that patient-generated data from Internet sources could be used to improve drug safety and pharmacovigilance, few studies have identified such data sources in Japan. We introduce a unique Japanese data source: tōbyōki, which translates literally as "an account of a struggle with disease." OBJECTIVE: The objective of this study was to evaluate the basic characteristics of the TOBYO database, a collection of tōbyōki blogs on the Internet, and discuss potential applications for pharmacovigilance...
February 24, 2017: JMIR Public Health and Surveillance
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