Ya-Hui Ma, Ling-Xiao Shen, Yu-Zhu Li, Yue Leng, Liu Yang, Shi-Dong Chen, Xiao-Yu He, Ya-Ru Zhang, Ren-Jie Chen, Jian-Feng Feng, Lan Tan, Qiang Dong, John Suckling, A David Smith, Wei Cheng, Jin-Tai Yu
BACKGROUND: Whether lung function prospectively affects cognitive brain health independent of their overlapping factors remains largely unknown. This study aimed to investigate the longitudinal association between decreased lung function and cognitive brain health and to explore underlying biological and brain structural mechanisms. METHODS: This population-based cohort included 43,1834 non-demented participants with spirometry from the UK Biobank. Cox proportional hazard models were fitted to estimate the risk of incident dementia for individuals with low lung function...
February 14, 2023: Brain, Behavior, and Immunity