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https://www.readbyqxmd.com/read/29793215/in-silico-insight-into-voltage-gated-sodium-channel-1-7-inhibition-for-anti-pain-drug-discovery
#1
Mingxing Wang, Wei Li, Ying Wang, Yongbo Song, Jian Wang, Maosheng Cheng
Studies on human genetics have implicated the voltage-gated sodium channel Nav1.7 as an appealing target for the treatment of pain. In this study, we put forward a ligand-based pharmacophore for the first time, which was generated by a set of multiple chemical scaffolds including sulfonamide and non-sulfonamide derivatives and consisted of four chemical features: an aromatic ring, a hydrophobic group and two hydrogen acceptors. The active cavity was divided into three regions according to the properties of the amino acids surrounded and was used for the docking of 16 known active inhibitors...
May 18, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29793085/socio-demographic-factors-associated-with-choosing-violent-methods-of-suicide-2011-2016-ilam-province
#2
Yousef Veisani, Fathola Mohamadian, Ali Delpisheh, Salman Khazaei
BACKGROUND: In new strategies towards of suicide prevention the best approach currently is based on specific method had specific risk factors. Therefore in this study we aimed to find out the association between socio-demographic factors and methods in completed suicide, 2011-2016, Ilam province. METHODS: A cross-sectional study, 2011-2016, was conducted. A total of 540 completed suicides were recruited to the study. Data were collected by systematic registration suicide data (SRSD) and Legal Medicine Organization (LMO)...
May 21, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29793038/therapeutic-drug-monitoring-and-safety-of-voriconazole-therapy-in-patients-with-child-pugh-class-b-and-c-cirrhosis-a-multicenter-study
#3
Taotao Wang, Miao Yan, Dan Tang, Ling Xue, Tao Zhang, Yuzhu Dong, Li Zhu, Xinggang Wang, Yalin Dong
OBJECTIVES: The purpose of this study was to investigate the pharmacokinetic profile and safety of voriconazole treatment in patients with Child-Pugh class B and C cirrhosis. METHODS: Liver cirrhosis patients receiving recommended voriconazole maintenance dose (group A) and halved maintenance dose (group B) orally or intravenously were involved. Voriconazole-related adverse events (AEs) were defined according to Common Terminology Criteria for Adverse Events. RESULTS: A total of 110 voriconazole Cmin were monitored from 78 patients...
May 21, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29792995/lumbar-discectomy-is-associated-with-higher-rates-of-lumbar-fusion
#4
Hector Castillo, Ravi Chintapalli, Harout Boyajian, Sebastian A Cruz, Vince K Morgan, Lewis L Shi, Michael J Lee
BACKGROUND CONTEXT: Lumbar disc herniation affects over three million people in the United States every year, and the rate of operation continually increases, particularly in patients 60 years or older.1,2 Surgical discectomy is a common treatment for lumbar disc herniation.1,3 One concern for this method is the risk of undergoing additional surgeries. 2,5,7 There are very limited population-level studies that examine the rate of lumbar fusion following lumbar discectomy. Additionally, there is no study that examines the risk of undergoing lumbar fusion in patients who have undergone lumbar discectomies compared to the risk of lumbar fusion in the general population with no previous lumbar discectomy...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792993/responsiveness-of-the-japanese-orthopaedic-association-back-pain-evaluation-questionnaire-in-lumbar-surgery-and-its-threshold-for-indicating-clinically-important-differences
#5
Takahito Fujimori, Toshitada Miwa, Takenori Oda
BACKGROUND CONTEXT: Introduced in 2007, the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) has been widely used, but its psychometric properties have not been well studied. PURPOSE: To assess the responsiveness and the clinically important differences of JOABPEQ for lumbar surgery. STUDY DESIGN: Prospective study. PATIENT SAMPLE: Two hundreds and three consecutive patients underwent lumbar surgeries between July 2013 and November 2015 in a single hospital...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792970/investigation-of-the-efficacy-of-alcohol-based-solutions-on-adenovirus-serotypes-8-19-and-37-the-common-cause-of-epidemic-keratoconjunctivitis-after-an-adenovirus-outbreak-occurred-in-the-hospital
#6
Hüseyin Uzuner, Aynur Karadenizli, Doğanhan Kadir Er, Agim Osmani
BACKGROUND: Hand antiseptics are of great importance in the prevention of nosocomial infections. Due to the frequent occurrence of adenoviral epidemic keratoconjunctivitis outbreaks in our hospital, we needed to detect the efficiency of alcohol-based-solutions on adenovirus. AIM: To investigate the efficacy of alcohol-based-solutions, that commonly found in hand-antiseptics against adenovirus 8, 19 and 37. METHODS: We investigated the efficacy of ethanol, isopropanol, chlorhexidine-digluconate, n-butanol and different combinations of these antiseptics on adenovirus serotypes that typically cause to epidemic keratoconjunctivitis...
May 21, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29792967/validated-reverse-phase-hplc-diode-array-method-for-the-quantification-of-intact-bevacizumab-infliximab-and-trastuzumab-for-long-term-stability-study
#7
Antonio Martínez-Ortega, Agustín Herrera, Antonio Salmerón-García, José Cabeza, Luis Cuadros-Rodríguez, Natalia Navas
The aim of the present study was to develop suitable and reliable method for quantification three of the most worldwide used therapeutic monoclonal antibodies (mAbs) -bevazizumab (BVZ), infliximab (INF) and trastuzumab (TTZ)- to be used in long-term stability studies. Reverse phase (RP) was selected by its greater sensibility and reproducibility comparing with other chromatographic modes. Then a high performance liquid chromatography with diode array detection (RP)HPLC/DAD method was checked. Since the three mAbs represent the active ingredient in the medicines in which they are formulated, the selected method was validated for each one in accordance with the International Conference on Harmonization (ICH) guidelines for pharmaceuticals for human use...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792921/characterization-of-solution-stress-degradation-products-of-aliskiren-and-prediction-of-their-physicochemical-and-admet-properties
#8
Bhoopendra Singh Kushwah, Jugal Gupta, Dilip Kumar Singh, Moolchand Kurmi, Archana Sahu, Saranjit Singh
Forced degradation studies on aliskiren were carried out according to ICH and WHO guidelines. Six degradation products were formed in total in the solution state. Their separation among themselves and from the drug was successfully achieved on a C-18 column utilizing acetonitrile and phosphate buffer (pH 3.0) in the mobile phase, which was run in a gradient mode. To characterize them, a complete mass fragmentation pathway of the drug was first established with the help of MS/TOF and MSn data. This was followed by LC-MS/TOF studies on the degradation products...
May 21, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29792809/thionine-self-assembled-structures-on-graphene-formation-organization-and-doping
#9
Thiago Sousa, Thales Fernando Damasceno Fernandes, Matheus J S Matos, Eduardo Nery Duarte Araujo, Mario S C Mazzoni, Bernardo R A Neves, Flávio Plentz
The association of organic molecules with 2D materials, creating hybrid systems with mutual influences, constitutes an important testbed for both basic science self-assembly studies and perspective applications. Following this concept, in this work, we show a rich phenomenology that is involved in the interaction of thionine with graphene, leading to a hybrid material formed by well-organized self-assembled structures atop graphene. This composite system is investigated by atomic force microscopy, electric transport measurements, and first principles calculations, which show: 1) an interesting time evolution of thionine self-assembled structures atop graphene; 2) the final molecular assembly is highly oriented (in accordance with the underlying graphene surface symmetry); and 3) thionine introduces a strong n-type doping effect in graphene...
May 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29792777/dismantling-a-complex-of-anther-smuts-microbotryum-on-carnivorous-plants-in-the-genus-pinguicula
#10
Rebekka Ziegler, Matthias Lutz, Jolanta Piątek, Marcin Piątek
The anther smuts of the genus Microbotryum are known from host plant species belonging to the Caryophyllaceae, Dipsacaceae, Lamiaceae, Lentibulariaceae, Montiaceae, and Primulaceae. Of these, the anther smuts on Caryophyllaceae, in particular on Silene spp., are best known because they include model organisms studied in many disciplines of fungal biology. For Microbotryum species parasitic on Caryophyllaceae, a high degree of host specificity was revealed and several cryptic species were described. In contrast, the host specificity within Microbotryum pinguiculae occurring in anthers of different Pinguicula species (Lentibulariaceae) has not been investigated in detail until now...
March 15, 2018: Mycologia
https://www.readbyqxmd.com/read/29792774/when-the-good-looks-bad-an-experimental-exploration-of-the-repulsion-effect
#11
Mikhail S Spektor, David Kellen, Jared M Hotaling
When people are choosing among different options, context seems to play a vital role. For instance, adding a third option can increase the probability of choosing a similar dominating option. This attraction effect is one of the most widely studied phenomena in decision-making research. Its prevalence, however, has been challenged recently by the tainting hypothesis, according to which the inferior option contaminates the attribute space in which it is located, leading to a repulsion effect. In an attempt to test the tainting hypothesis and explore the conditions under which dominated options make dominating options look bad, we conducted four preregistered perceptual decision-making studies with a total of 301 participants...
May 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29792591/comprehensive-evolutionary-and-phylogenetic-analysis-of-hepacivirus-n-hnv
#12
M S da Silva, D M Junqueira, L F Baumbach, S P Cibulski, A C S Mósena, M N Weber, S Silveira, G M de Moraes, R D Maia, V C S Coimbra, C W Canal
Hepaciviruses (HVs) have been detected in several domestic and wild animals and present high genetic diversity. The actual classification divides the genus Hepacivirus into 14 species (A-N), according to their phylogenetic relationships, including the bovine hepacivirus [Hepacivirus N (HNV)]. In this study, we confirmed HNV circulation in Brazil and sequenced the whole genome of two strains. Based on the current classification of HCV, which is divided into genotypes and subtypes, we analysed all available bovine hepacivirus sequences in the GenBank database and proposed an HNV classification...
May 24, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29792559/frozen-white-leg-shrimp-litopenaeus-vannamei-in-korean-markets-as-a-source-of-aeromonas-spp-harboring-antibiotic-and-heavy-metal-resistance-genes
#13
Benthotage C J De Silva, Sabrina Hossain, Pasan S Dahanayake, Gang-Joon Heo
As the most consumed shrimp variety, white-leg shrimp (Litopenaeus vannamei) owns a high market demand in Korea. This study sought to screen the frozen white-leg shrimp for Aeromonas spp. harboring antimicrobial and heavy metal resistance characteristics. A total of 44 Aeromonas spp. strains were isolated and tested for antibiotic susceptibility and heavy metal tolerance followed by PCR-based detection of resistance genes and integrons. It was observed that resistance to ampicillin and oxacillin was 100% among isolates...
May 24, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29792505/a-new-test-for-the-assessment-of-working-memory-in-clinical-settings-validation-and-norming-of-a-month-ordering-task
#14
Imke Buekenhout, José Leitão, Ana A Gomes
Month ordering tasks have been used in experimental settings to obtain measures of working memory (WM) capacity in older/clinical groups based solely on their face validity. We sought to assess the appropriateness of using a month ordering task in other contexts, including clinical settings, as a psychometrically sound WM assessment. To this end, we constructed a month ordering task (ucMOT), studied its reliability (internal consistency and temporal stability), and gathered construct-related and criterion-related validity evidence for its use as a WM assessment...
May 24, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29792504/measurement-invariance-of-tgmd-3-in-children-with-and-without-mental-and-behavioral-disorders
#15
Daniele Magistro, Giovanni Piumatti, Fabio Carlevaro, Lauren B Sherar, Dale W Esliger, Giulia Bardaglio, Francesca Magno, Massimiliano Zecca, Giovanni Musella
This study evaluated whether the Test of Gross Motor Development 3 (TGMD-3) is a reliable tool to compare children with and without mental and behavioral disorders across gross motor skill domains. A total of 1,075 children (aged 3-11 years), 98 with mental and behavioral disorders and 977 without (typically developing), were included in the analyses. The TGMD-3 evaluates fundamental gross motor skills of children across two domains: locomotor skills and ball skills. Two independent testers simultaneously observed children's performances (agreement over 95%)...
May 24, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29792395/how-are-patients-with-heart-failure-treated-in-primary-care
#16
Hélène Vaillant-Roussel, Bruno Pereira, Sylvaine Gibot-Boeuf, Romain Eschalier, Claude Dubray, Rémy Boussageon, Philippe Vorilhon
OBJECTIVE: The aim of this study was to assess the adherence of general practitioners (GPs) to guidelines in patients with heart failure with reduced ejection fraction (HFrEF) and to describe GPs' prescribing behavior regarding patients with heart failure with preserved ejection fraction (HFpEF). MATERIALS AND METHODS: Cross-sectional study as part of the ETIC trial. Five classes of drugs were described: angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs); β-blockers (BBs); mineralocorticoid receptor antagonists (MRAs); diuretics (thiazide or loop diuretics); and digoxin...
May 24, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29792295/supply-and-demand-in-mhealth-apps-for-persons-with-multiple-sclerosis-systematic-search-in-app-stores-and-scoping-literature-review
#17
REVIEW
Guido Giunti, Estefanía Guisado Fernández, Enrique Dorronzoro Zubiete, Octavio Rivera Romero
BACKGROUND: Multiple sclerosis (MS) is a non-curable chronic inflammatory disease of the central nervous system that affects more than 2 million people worldwide. MS-related symptoms impact negatively on the quality of life of persons with MS, who need to be active in the management of their health. mHealth apps could support these patient groups by offering useful tools, providing reliable information, and monitoring symptoms. A previous study from this group identified needs, barriers, and facilitators for the use of mHealth solutions among persons with MS...
May 23, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29792281/the-impact-of-body-weight-on-stapled-anastomosis-in-pediatric-patients
#18
Hizuru Amano, Yujiro Tanaka, Takahisa Tainaka, Akinari Hinoki, Hiroshi Kawashima, Tomo Kakihara, Kaori Morita, Hiroo Uchida
PURPOSE: The purpose of this study is to clarify the impact of body weight on outcomes of stapled anastomosis in pediatric patients. METHODS: A total of 253 pediatric patients who underwent intestinal anastomosis were classified according to body weight (<3.5 kg: light group, ≥3.5 kg: heavy group), and clinical outcomes of stapled and hand-sewn anastomoses were compared. RESULTS: The light and heavy groups included 77 (stapled: n = 13, hand-sewn: n = 64) and 176 (stapled: n = 58, hand-sewn: n = 118) patients, respectively...
April 26, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29792274/ex-vivo-expanded-natural-regulatory-t-cells-from-patients-with-end-stage-renal-disease-or-kidney-transplantation-are-useful-for-autologous-cell-therapy
#19
Sybille Landwehr-Kenzel, Anne Zobel, Henrike Hoffmann, Niels Landwehr, Michael Schmueck-Henneresse, Thomas Schachtner, Andy Roemhild, Petra Reinke
Novel concepts employing autologous, ex vivo expanded natural regulatory T cells (nTreg) for adoptive transfer has potential to prevent organ rejection after kidney transplantation. However, the impact of dialysis and maintenance immunosuppression on the nTreg phenotype and peripheral survival is not well understood, but essential when assessing patient eligibility. The current study investigates regulatory T-cells in dialysis and kidney transplanted patients and the feasibility of generating a clinically useful nTreg product from these patients...
June 2018: Kidney International
https://www.readbyqxmd.com/read/29792243/understanding-the-science-of-portion-control-and-the-art-of-downsizing
#20
Marion M Hetherington, Pam Blundell-Birtill, Samantha J Caton, Joanne E Cecil, Charlotte E Evans, Barbara J Rolls, Tang Tang
Offering large portions of high-energy-dense (HED) foods increases overall intake in children and adults. This is known as the portion size effect (PSE). It is robust, reliable and enduring. Over time, the PSE may facilitate overeating and ultimately positive energy balance. Therefore, it is important to understand what drives the PSE and what might be done to counter the effects of an environment promoting large portions, especially in children. Explanations for the PSE are many and diverse, ranging from consumer error in estimating portion size to simple heuristics such as cleaning the plate or eating in accordance with consumption norms...
May 24, 2018: Proceedings of the Nutrition Society
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