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https://www.readbyqxmd.com/read/29775089/detection-of-perimacular-red-dots-and-blots-when-screening-for-diabetic-retinopathy-refer-or-not-refer
#1
Anatolie Baltatescu, Elio Striglia, Marina Trento, Aurora Mazzeo, Franco Cavallo, Lorena Charrier, Massimo Porta
PURPOSE: Detection of microaneurysms and/or microhaemorrhages near the fovea when screening for diabetic retinopathy poses a problem because referral to retinal specialists may alarm patients and unnecessarily burden ophthalmologists. METHODS: Six-month prospective study of patients found to have minimal red lesions within one disc diameter of the fovea when screened for diabetic retinopathy. Two 45° digital photographs, one centred on the macula and the other nasal including the optic disc, were taken for each eye...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29771751/utility-of-optical-coherence-tomography-in-the-evaluation-of-sellar-and-parasellar-mass-lesions
#2
Omar Al-Louzi, Sashank Prasad, Robert M Mallery
PURPOSE OF REVIEW: Anterior visual pathway compression is a common feature of sellar region masses. We review the visual pathway neuroanatomy pertaining to sellar and parasellar lesions and describe recent advances in optical coherence tomography (OCT) imaging that have provided a novel quantitative perspective in the evaluation and management of such patients. RECENT FINDINGS: Ultrastructural measurements of optic nerve integrity using OCT, namely peripapillary retinal nerve fiber layer (pRNFL) and the ganglion cell and inner plexiform layer (GCIPL) thicknesses, have been shown to correlate with visual acuity and visual field deficits on perimetry in patients with compressive sellar region masses...
May 15, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29771733/haemodilution-and-head-down-tilting-induce-functional-injury-in-the-rat-optic-nerve-a-model-for-peri-operative-ischemic-optic-neuropathy
#3
Steven Roth, John Dreixler, Nancy J Newman
BACKGROUND: Mechanisms of peri-operative ischaemic optic neuropathy remain poorly understood. Both specific pre-operative and intra-operative factors have been examined by retrospective studies, but no animal model currently exists. OBJECTIVES: To develop a rodent model of peri-operative ischaemic optic neuropathy. In rats, we performed head-down tilt and/or haemodilution, theorising that the combination damages the optic nerve. DESIGN: Animal study...
May 15, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29768035/microgravity-induced-ocular-changes-are-related-to-body-weight
#4
Jay C Buckey, Scott D Phillips, Allison P Anderson, Ariane B Chepko, Veronique Archambault-Leger, Jiang Gui, Abigail M Fellows
On Earth, tissue weight generates compressive forces that press on body structures and act on the walls of vessels throughout the body. In microgravity tissues no longer have any weight and tissue compressive forces are lost, suggesting individuals who weigh more may show greater effects from microgravity exposure. One unique effect of long-duration microgravity exposure is the spaceflight-associated neuro-ocular syndrome (SANS) which can present with globe flattening, choroidal folds, optic disc edema, and a hyperopic visual shift...
May 16, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29763758/probe-of-zrtio-2-thin-films-with-tio-2-zro-2-binary-oxides-deposited-by-dip-coating-technique
#5
Zohra N Kayani, Anum Kamran, Zeb Saddiqe, Saira Riaz, Shahzad Naseem
Zirconium Titanium dioxide (TiO2 : Zr) thin films were synthesized on glass substrates by the dip coating technique. The structural, optical, magnetic, photo-catalytic and antibacterial properties were explored for the films synthesized with zirconium concentration 10, 15, 20, 25 and 30 at.%. X-ray diffraction (XRD) revealed that the thin films contain anatase-rutile-brookite TiO2 and cubic-ZrO2 phases. Moreover, it was noticed that ZrO2 retarded the anatase-to-rutile transformation at high Zr doping percentage...
May 1, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29757809/applicability-of-isnt-rule-using-bmo-mrw-to-differentiate-between-healthy-and-glaucomatous-eyes
#6
Do Young Park, Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: We evaluated the applicability of the ISNT rule using Bruch's membrane opening minimum rim width (BMO-MRW) in healthy eyes and eyes with normal tension glaucoma (NTG). METHODS: 124 healthy eyes and 136 NTG eyes were analyzed. Using two-dimensional disc photographs, neuroretinal rim (NRR) thickness was measured at the superior, inferior, nasal, and temporal sides of the optic disc. Using spectral domain-optical coherence tomography (SD-OCT), BMO-MRW was measured at the same regions...
May 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29755824/olfactory-neuroblastoma-a-rare-cause-of-external-ophthalmoplegia-proptosis-and-compressive-optic-neuropathy
#7
Ömer Kartı, Mehmet Özgür Zengin, Ozan Çelik, Taşkın Tokat, Tuncay Küsbeci
Olfactory neuroblastoma (ONB), which is a neuroectodermal tumor of the nasal cavity, is a rare and locally aggressive malignancy that may invade the orbit via local destruction. In this study, we report a patient with proptosis, external ophthalmoplegia, and compressive optic neuropathy caused by ONB. A detailed clinical examination including ocular imaging and histopathological studies were performed. The 62-year-old female patient presented to our clinic with complaints of proptosis and visual deterioration in the left eye...
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29755274/nut-carcinoma-of-the-sinonasal-tract-infiltrating-the-orbit-in-a-man-with-birdshot-chorioretinitis
#8
Wesley Chan, Martin J Bullock, Arif F Samad, Curtis W Archibald, J Godfrey Heathcote
A 48-year-old man with a history of birdshot chorioretinitis presented with blurry vision, retro-bulbar pain and sinusitis. Though visual acuity was unaffected, he had left optic disc oedema and mild restriction of left eye abduction. His symptoms progressed quickly, with diplopia in primary gaze, epistaxis from his left nostril, and a left relative afferent pupillary defect (RAPD). On computed tomography, there was a mass in the nasal cavity that extended through the left cribriform plate and lamina papyracea and posteriorly into the optic canal...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29753854/occurrence-of-phosphenes-in-patients-undergoing-proton-beam-therapy-for-ocular-tumor
#9
Thibaud Mathis, Petter Hofverberg, Jean-Pierre Caujolle, Joël Hérault, Cécilia Leal, Celia Maschi, Benoit Delaunay, Stéphanie Baillif, Laurent Kodjikian, Juliette Thariat
PURPOSE: Phosphenes are frequently reported by patients irradiated in the head and neck area. The aim of the present study was to characterize and investigate potential mechanisms of proton beam therapy (PBT)-induced phosphenes in a large population of patients undergoing PBT for ocular tumors. DESIGN: Prospective cohort study METHODS: Consecutive patients who underwent PBT in a single center were included. Immediately after the first session, all patients completed a questionnaire collecting information about the presence of phosphenes as well as their color, shape, and duration...
May 10, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750947/glaucoma-specialist-optic-disc-margin-rim-margin-and-rim-width-discordance-in-glaucoma-and-glaucoma-suspect-eyes
#10
Seung Woo Hong, Helen Koenigsman, Ruojin Ren, Hongli Yang, Stuart K Gardiner, Juan Reynaud, Robert M Kinast, Steven L Mansberger, Brad Fortune, Shaban Demirel, Claude F Burgoyne
PURPOSE: To quantify the variability of 5 glaucoma specialists' optic disc margin (DM), rim margin (RM) and rim width (RW) estimates. DESIGN: Inter-Observer Reliability analysis. METHODS: Clinicians viewed stereo-photos from 214 subjects with glaucoma or ocular hypertension and digitally marked the DM and RM. For each photo, the centroid of each clinician's DM was calculated, and an averaged DMcentroid was determined. The axis between the DMcentroid and the fovea was used to establish twelve 30° sectors...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750713/valsalva-maneuver-and-peripapillary-oct-angiography-vessel-density
#11
Gábor Holló
PURPOSE: To investigate the potential influence of breath holding on the results of peripapillary vessel density (VD) measurement with optical coherence tomography angiography (OCTA). METHODS: Three peripapillary VD measurements were made at 2-minute intervals on the right eye of 12 healthy young volunteers using the Angiovue/RTvue-XR OCT (software version 2017.1, Phase 7 update) without changing the head and body positions. During the first 2 measurements the volunteers were breathing normally...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29750124/a-small-disc-area-is-a-risk-factor-for-visual-field-loss-progression-in-primary-open-angle-glaucoma-the-glaucoma-stereo-analysis-study
#12
Yasushi Kitaoka, Masaki Tanito, Yu Yokoyama, Koji Nitta, Maki Katai, Kazuko Omodaka, Toru Nakazawa
Purpose: The Glaucoma Stereo Analysis Study, a cross-sectional multicenter collaborative study, used a stereo fundus camera (nonmyd WX) to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients. We compared the associations of each parameter between the visual field loss progression group and no-progression group. Methods: The study included 187 eyes of 187 patients with primary open-angle glaucoma or normal-tension glaucoma. We divided the mean deviation (MD) slope values of all patients into the progression group (<-0...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29748605/targeting-circular-rna-zranb1-for-therapeutic-intervention-in-retinal-neurodegeneration
#13
Jia-Jian Wang, Kun Shan, Bai-Hui Liu, Chang Liu, Rong-Mei Zhou, Xiu-Miao Li, Rui Dong, Shu-Jie Zhang, Sheng-Hai Zhang, Ji-Hong Wu, Biao Yan
Glaucoma is a neurodegenerative disease characterized by retinal ganglion cell (RGC) loss, optic disc excavation, and progressive visual field loss. Direct or indirect ameliorating retinal neurodegeneration is a promising therapeutic therapy for glaucoma. Circular RNAs (circRNAs) are a class of covalently closed circular RNA transcripts and have emerged as potential regulators in several neurodegenerative diseases. In this study, we show that cZRANB1 expression is significantly upregulated in retinal neurodegeneration induced by glaucoma...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29747089/effects-of-high-intensity-interval-training-on-optic-nerve-head-and-macular-perfusion-using-optical-coherence-tomography-angiography-in-healthy-adults
#14
Boris Schmitz, Pieter Nelis, Florian Rolfes, Maged Alnawaiseh, Andreas Klose, Michael Krüger, Nicole Eter, Stefan-Martin Brand, Florian Alten
BACKGROUND AND AIMS: High-intensity interval training (HIIT) has been identified to be efficient for increasing health-related fitness in general and in lifestyle-induced chronic diseases such as hypertension, obesity and metabolic syndrome. This study aimed to evaluate HIIT effects on optic nerve head (ONH) and macular perfusion in healthy adults using optical coherence tomography angiography (OCTA). METHODS: Fifty-eight healthy participants (22.0 ± 2.02 years, 40 females (69...
April 26, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29746406/hemi-temporal-internal-limiting-membrane-peeling-is-as-effective-and-safe-as-conventional-full-peeling-for-macular-hole-surgery
#15
Akira Shiono, Jiro Kogo, Hiroki Sasaki, Ryo Yomoda, Tatsuya Jujo, Naoto Tokuda, Yasushi Kitaoka, Hitoshi Takagi
PURPOSE: To investigate the efficacy of hemi-temporal internal limiting membrane (ILM) peeling for idiopathic macular hole. METHODS: The medical records of patients with macular holes who had undergone vitrectomy with ILM peeling were studied. Forty-two eyes with macular hole were divided into 2 groups based on surgical procedure (hemi-temporal ILM peeling [hemi group]: 15 eyes; 360° ILM peeling [360° group]: 27 eyes). The closure rates and distances between the optic disc and the intersection of two retinal vessels most closely located nasally or temporally to the macular hole were compared...
May 9, 2018: Retina
https://www.readbyqxmd.com/read/29745528/-a-novel-method-of-optic-disk-segmentation-based-on-visual-saliency-and-rotary-scanning
#16
Xinrong Cao, Lanyan Xue, Jiawen Lin, Lun Yu
Fast optic disk localization and boundary segmentation is an important research topic in computer aided diagnosis. This paper proposes a novel method to effectively segment optic disk by using human visual characteristics in analyzing and processing fundus image. After a general analysis of optic disk features in fundus images, the target of interest could be located quickly, and intensity, color and spatial distribution of the disc are used to generate saliency map based on pixel distance. Then the adaptive threshold is used to segment optic disk...
April 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29740745/a-novel-method-for-retinal-optic-disc-detection-using-bat-meta-heuristic-algorithm
#17
Ahmad S Abdullah, Yasa Ekşioğlu Özok, Javad Rahebi
Normally, the optic disc detection of retinal images is useful during the treatment of glaucoma and diabetic retinopathy. In this paper, the novel preprocessing of a retinal image with a bat algorithm (BA) optimization is proposed to detect the optic disc of the retinal image. As the optic disk is a bright area and the vessels that emerge from it are dark, these facts lead to the selected segments being regions with a great diversity of intensity, which does not usually happen in pathological regions. First, in the preprocessing stage, the image is fully converted into a gray image using a gray scale conversion, and then morphological operations are implemented in order to remove dark elements such as blood vessels, from the images...
May 9, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29739345/atypical-central-retinal-artery-occlusion-as-the-first-presentation-of-poems-syndrome-a-case-report
#18
Panitha Jindahra, Charungthai Dejthevaporn, Pimjai Niparuck, Jariya Waisayarat, Piyaphon Cheecharoen, Thanatporn Threetong, Purit Petpiroon, Tharikarn Sujirakul, Anuchit Poonyathalang, Kavin Vanikieti
BACKGROUND: POEMS syndrome is a plasma cell disorder, which clinically manifests from paraneoplastic syndrome: polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes. The most common ocular manifestation is optic disc swelling, whereas other ocular manifestations; cystoid macular edema, serous macular detachment, venous sinus thrombosis, infiltrative orbitopathy, uveitis, neovascularization of the disc, peripapillary choroidal neovascularization and optic disc drusen, had also been reported...
May 8, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29733809/optical-coherence-tomography-angiography-in-optic-disc-swelling
#19
Masoud Aghsaei Fard, Jalil Jalili, Alireza Sahraiyan, Hassan Khojasteh, Marjane Hejazi, Robert Ritch, Prem S Subramanian
PURPOSE: To compare optical coherence tomography angiography (OCT-A) of peripapillary total vasculature and capillaries in patients with optic disc swelling. DESIGN: Cross-sectional study. METHODS: Twenty nine eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION), 44 eyes with papilledema, 8 eyes with acute optic neuritis, and 48 eyes of normal subjects were imaged using OCT-A. Peripapillary total vasculature information was recorded using a commercial vessel density map...
May 4, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29732468/clinical-characteristics-of-chronic-central-serous-chorioretinopathy-patients-with-insufficient-response-to-reduced-settings-photodynamic-therapy
#20
Thomas J van Rijssen, Elon H C van Dijk, Greet Dijkman, Camiel J F Boon
PURPOSE: To identify characteristics of Caucasian chronic central serous chorioretinopathy (cCSC) patients without a complete resolution of subretinal fluid (SRF) after reduced-settings photodynamic therapy (PDT), or with a recurrence of SRF after PDT. METHODS: Chronic CSC patients treated with reduced-settings PDT were divided into a successful PDT group and unsuccessful PDT group. Patients in the successful PDT group did not have any subretinal fluid (SRF) during follow-up after PDT, whereas the unsuccessful PDT group was categorized based on either persistence or recurrence of SRF after PDT treatment...
May 7, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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