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https://www.readbyqxmd.com/read/29667530/effects-of-developmental-age-on-symptom-reporting-and-neurocognitive-performance-in-youth-after-sports-related-concussion-compared-to-control-athletes
#1
Donna L Murdaugh, Kim E Ono, Sarah O Morris, Thomas G Burns
There is increased necessity to focus research on school-aged athletes with sports-related concussion (SRC). This study assessed differences in symptom reporting and neurocognitive performance in youth athletes who sustained a sports-related concussion. A total of 1345 concussed and 3529 nonconcussed athletes (ages 8-21) completed the Immediate Post-concussive Assessment and Cognitive Testing (ImPACT). Analyses of covariance were conducted in order to assess differences in neurocognitive performance and symptom reporting between the sports-related concussion and control groups across age ranges...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29666161/implementation-of-the-sepsis-risk-calculator-at-an-academic-birth-hospital
#2
Miren B Dhudasia, Sagori Mukhopadhyay, Karen M Puopolo
BACKGROUND: Multivariate predictive models for estimating the risk of neonatal early-onset sepsis (EOS) are available as a Web-based sepsis risk calculator (SRC) and may reduce the proportion of newborns empirically treated with antibiotics after birth. EOS risk assessment based on such models would require workflow changes at most birth hospitals. METHODS: A multidisciplinary team of obstetric, neonatal, and information technology staff at a large, academic, birth hospital collaborated to implement the SRC...
April 17, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29663569/spiritual-and-religious-coping-and-depression-among-family-caregivers-of-pediatric-cancer-patients-in-latin-america
#3
Luciano Magalhães Vitorino, Luís Carlos Lopes-Júnior, Gabriela Hernandes de Oliveira, Mariane Tenaglia, Andressa Brunheroto, Paulo José Oliveira Cortez, Giancarlo Lucchetti
OBJECTIVE: Several studies have shown that spiritual/religious beliefs are associated with mental health and quality of life. However, so far, no study assessed the relationship between spiritual/religious coping (SRC) and depressive symptoms in family caregivers (FCs) of pediatric cancer patients, particularly in Latin America. This study aimed to investigate whether Positive and Negative SRC strategies are associated with depressive symptoms in FCs of pediatric cancer patients in Brazil...
April 16, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29662665/molecular-mechanism-of-action-and-potential-biomarkers-of-growth-inhibition-of-synergistic-combination-of-afatinib-and-dasatinib-against-gefitinib-resistant-non-small-cell-lung-cancer-cells
#4
Miao Wang, Alex Yuang-Chi Chang
Epidermal growth factor receptor - tyrosine kinase inhibitor (EGFR-TKI) is the first choice of treatment for advanced non-small cell lung cancer (NSCLC) patients harbouring activating EGFR mutations. However, single agent usually has limited efficacy due to heterogeneous resistant mechanisms of cancer cells. Thus drug combination therapy would offer more benefits by synergistic interactions and avoidance of resistance emergence. In this study, we selected 8 NSCLC cell lines with different genetic characteristics as research models to investigate the efficacy of 4 agents (gefitinib, cetuximab, afatinib and dasatinib) and their combinations...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661276/postoperative-morbidity-and-mortality-for-malignant-colon-obstruction-the-american-college-of-surgeon-calculator-reliability
#5
Maxime K Collard, David Moszkowicz, Anne-Caroline Clause-Verdreau, Alain Beauchet, Tristan Cudennec, Karina Vychnevskaia, Robert Malafosse, Frédérique Peschaud
BACKGROUND: The American College of surgical risk calculator (SRC) score has never been validated specifically for surgery in emergency. The objective was to evaluate the reliability of this calculator in patients with malignant colon obstruction. MATERIALS AND METHODS: We retrospectively have analyzed the morbidity and mortality observed in operated patients. Risk factors for postoperative morbidity and mortality were analyzed by logistic regression model. We have compared the morbidity and mortality estimated by the SRC score with that observed using the Brier Score (BS)...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29660890/initial-changes-in-soil-properties-and-carbon-sequestration-potential-under-monocultures-and-short-rotation-alley-coppices-with-poplar-and-willow-after-three-years-of-plantation
#6
Azeem Tariq, Anna Gunina, Norbert Lamersdorf
Initial changes in soil structure and C stocks were studied under short-rotation coppices (SRC) planted on former cropland near Göttingen, Central Germany. Plantations were established either as monocultures with willow (Willow-SRC) or poplar (Poplar-SRC), or as an agroforestry system with willow strips and grassland alleys in between (Willow-AF). A neighbouring cropland served as a control. Three sampling campaigns were applied in this study. The first sampling was conducted at a fine scale to reveal the differences in soil C with depth (i...
April 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29660364/silibinin-is-a-direct-inhibitor-of-stat3
#7
Sara Verdura, Elisabet Cuyàs, Laura Llorach-Parés, Almudena Pérez-Sánchez, Vicente Micol, Alfons Nonell-Canals, Jorge Joven, Manuel Valiente, Melchor Sánchez-Martínez, Joaquim Bosch-Barrera, Javier A Menendez
We herein combined experimental and computational efforts to delineate the mechanism of action through which the flavonolignan silibinin targets STAT3. Silibinin reduced IL-6 inducible, constitutive, and acquired feedback activation of STAT3 at tyrosine 705 (Y705). Silibinin attenuated the inducible phospho-activation of Y705 in GFP-STAT3 genetic fusions without drastically altering the kinase activity of the STAT3 upstream kinases JAK1 and JAK2. A comparative computational study based on docking and molecular dynamics simulation over 14 different STAT3 inhibitors (STAT3i) predicted that silibinin could directly bind with high affinity to both the Src homology-2 (SH2) domain and the DNA-binding domain (DBD) of STAT3...
April 13, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29658958/treatment-with-src-inhibitor-dasatinib-results-in-elevated-metastatic-potential-in-the-4t1-murine-mammary-carcinoma-model
#8
Veronica S Hughes, Dietmar W Siemann
Introduction: The src inhibitor Dasatinib has been widely studied as an anti-metastatic agent. The aims of this study were to examine the effect of Src inhibition on the metastatic potential of the 4T1 murine mammary carcinoma. Context: Src is a non-receptor tyrosine kinase well-known to contribute to the metastatic potential of tumour cells. It does so through alteration of signalling pathways important to metastasis. Elevated levels of Src are common in many cancer types, and have been correlated with tumour progression and poor patient prognosis...
2018: Tumor & microenvironment
https://www.readbyqxmd.com/read/29658350/vascular-endothelial-growth-factor-c-promotes-cervical-cancer-cell-invasiveness-via-regulation-of-microrna-326-cortactin-expression
#9
Yang Cheng, Shuyi Jiang, Jin Yuan, Junxiu Liu, Tommaso Simoncini
Vascular endothelial growth factor C (VEGF-C) accelerates cervical cancer metastasis, while the detailed mechanism remains largely unknown. Recent evidence indicates that microRNA play a crucial role in controlling cancer cell invasiveness. In the present study, we investigated the role of miR-326 in VEGF-C-induced cervical cancer cell invasion. VEGF-C expression was higher and miR-326 was much lower in primary cervical cancer specimens than that in non-cancerous specimens, and a negative correlation between VEGF-C and miR-326 was found...
April 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29653289/src-activation-decouples-cell-division-orientation-from-cell-geometry-in-mammalian-cells
#10
Xiaoyan Sun, Hongsheng Qi, Xiuzhen Zhang, Li Li, Jiaping Zhang, Qunli Zeng, George S Laszlo, Bo Wei, Tianhong Li, Jianxin Jiang, Alex Mogilner, Xiaobing Fu, Min Zhao
Orientation of cell division plane plays a crucial role in morphogenesis and regeneration. Misoriented cell division underlies many important diseases, such as cancer. Studies with Drosophila and C. elegance models show that Src, a proto-oncogene tyrosine-protein kinase, is a critical regulator of this aspect of mitosis. However, the role for Src in controlling cell division orientation in mammalian cells is not well understood. Using genetic and pharmacological approaches and two extracellular signals to orient cell division, we demonstrated a critical role for Src...
April 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29651879/src-kinase-activation-by-nitric-oxide-promotes-resistance-to-anoikis-in-tumour-cell-lines
#11
Paulo E da Costa, Wagner L Batista, Miriam S Moraes, Arnold Stern, Hugo P Monteiro
Tumour progression involves the establishment of tumour metastases at distant sites. Resistance to anoikis, a form of cell death that occurs when cells lose contact with the extracellular matrix and with neighbouring cells, is essential for metastases. NO has been associated with anoikis. NO treated HeLa cells and murine melanoma cells in suspension triggered a nitric oxide (NO)-Src kinase signalling circuitry that enabled resistance to anoikis. Two NO donors, sodium nitroprusside (SNP) (500 µM) and DETANO (125 µM), protected against cell death derived from detachment of a growth permissive surface (experimental anoikis)...
April 13, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29651006/cyclin-dependent-kinase-5-mediates-pleiotrophin-induced-endothelial-cell-migration
#12
Evgenia Lampropoulou, Ioanna Logoviti, Marina Koutsioumpa, Maria Hatziapostolou, Christos Polytarchou, Spyros S Skandalis, Ulf Hellman, Manolis Fousteris, Sotirios Nikolaropoulos, Efrosini Choleva, Margarita Lamprou, Angeliki Skoura, Vasileios Megalooikonomou, Evangelia Papadimitriou
Pleiotrophin (PTN) stimulates endothelial cell migration through binding to receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and αν β3 integrin. Screening for proteins that interact with RPTPβ/ζ and potentially regulate PTN signaling, through mass spectrometry analysis, identified cyclin-dependent kinase 5 (CDK5) activator p35 among the proteins displaying high sequence coverage. Interaction of p35 with the serine/threonine kinase CDK5 leads to CDK5 activation, known to be implicated in cell migration...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29649876/biomolecular-simulations-under-realistic-macroscopic-salt-conditions
#13
Gregory A Ross, Ariën S Rustenburg, Patrick B Grinaway, Josh Fass, John Damon Chodera
Biomolecular simulations are typically performed in an aqueous environment where the number of ions remains fixed for the duration of the simulation, generally with either a minimally neutralizing ion environment or a number of salt pairs intended to match the macroscopic salt concentration. In contrast, real biomolecules experience local ion environments where the salt concentration is dynamic and may differ from bulk. The degree of salt concentration variability and average deviation from the macroscopic concentration remains, as yet, unknown...
April 13, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29648462/a-systematic-review-of-neuroimaging-findings-in-children-and-adolescents-with-sports-related-concussion
#14
Emilie Chamard, Jonathan D Lichtenstein
BACKGROUND: Sport-related concussion (SRC) generally does not result in structural anomalies revealed through clinical imaging techniques such as MRI and CT. While advanced neuroimaging techniques offer another avenue to investigate the subtle alterations following SRC, the current pediatric literature in this area has yet to be reviewed. The aim of this review is to systematically explore the literature on magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), functional magnetic resonance imaging (fMRI), and cortical thickness following SRC in children and adolescents...
April 12, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29644001/bag3-promotes-tumour-cell-proliferation-by-regulating-egfr-signal-transduction-pathways-in-triple-negative-breast-cancer
#15
Sarah Shields, Emer Conroy, Tony O'Grady, Alo McGoldrick, Kate Connor, Mark P Ward, Zivile Useckaite, Eugene Dempsey, Rebecca Reilly, Yue Fan, Anthony Chubb, David Gomez Matallanas, Elaine W Kay, Darran O'Connor, Amanda McCann, William M Gallagher, Judith A Coppinger
Triple-negative breast cancer (TNBC), is a heterogeneous disease characterised by absence of expression of the estrogen receptor (ER), progesterone receptor (PR) and lack of amplification of human epidermal growth factor receptor 2 (HER2). TNBC patients can exhibit poor prognosis and high recurrence stages despite early response to chemotherapy treatment. In this study, we identified a pro-survival signalling protein BCL2- associated athanogene 3 (BAG3) to be highly expressed in a subset of TNBC cell lines and tumour tissues...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29629899/ask1-2-signaling-promotes-inflammation-in-a-mouse-model-of-neutrophilic-dermatosis
#16
Sarang Tartey, Prajwal Gurung, Tejasvi Krishna Dasari, Amanda Burton, Thirumala-Devi Kanneganti
Mice homozygous for the Tyr208Asn amino acid substitution in the carboxy terminus of Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1) (referred to as Ptpn6spin mice) spontaneously develop a severe inflammatory disease resembling neutrophilic dermatosis in humans. Disease in Ptpn6spin mice is characterized by persistent footpad swelling and suppurative inflammation. Recently, in addition to IL-1α and IL-1R signaling, we demonstrated a pivotal role for several kinases such as SYK, RIPK1, and TAK1 in promoting inflammatory disease in Ptpn6spin mice...
April 9, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29627857/do-already-grasped-objects-activate-motor-affordances
#17
Cristina Iani, Luca Ferraro, Natale Vincenzo Maiorana, Vittorio Gallese, Sandro Rubichi
This study investigated whether in a stimulus-response compatibility (SRC) task affordance effects in response to picture of graspable objects emerge when these objects appear as already grasped. It also assessed whether the observed effects could be explained as due to spatial compatibility between the most salient part in the object/display and the hand of response rather than to action potentiation. To this aim, we conducted three behavioural experiments in which participants were required to discriminate the vertical orientation (upright vs...
April 7, 2018: Psychological Research
https://www.readbyqxmd.com/read/29626537/intrinsically-disordered-proteins-link-alternative-splicing-and-post-translational-modifications-to-complex-cell-signaling-and-regulation
#18
Jianhong Zhou, Suwen Zhao, A Keith Dunker
Intrinsically disordered proteins and regions (IDPs and IDRs) lack well-defined tertiary structures, yet carry out various important cellular functions, especially those associated with cell signaling and regulation. In eukaryotes, IDPs and IDRs contain the preferred loci for both alternative splicing (AS) and many post-translational modifications (PTMs). Furthermore, AS and/or PTMs at these loci generally alter the signaling outcomes associated with these IDPs or IDRs, where the functional cooperation of these three features is named the IDP-AS-PTM toolkit...
April 4, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29625466/narrow-spectrum-kinase-inhibitors-demonstrate-promise-for-the-treatment-of-dry-eye-disease-and-other-ocular-inflammatory-disorders
#19
Suzanne Hagan, Matthew C T Fyfe, Boatemaa Ofori-Frimpong, Katherine Oliver, Martyn R Foster, Sameer Sirohi, Yemisi Solanke, Michael Doughty, Adele Rowley, Mike Taylor, Steve Webber, Claire A Walshe
Purpose: The purpose of this study is to determine the potential of narrow spectrum kinase inhibitors (NSKIs) to treat inflammatory eye disorders. Methods: Human conjunctival epithelial (HCE) cells were retrieved from subjects via impression cytology. Real-time quantitative PCR (qPCR) was performed on HCE cells to determine gene expression of NSKI kinase targets and proinflammatory cytokines in dry eye disease (DED) patients versus healthy controls. qPCR also assessed p38α expression in hyperosmolar-treated Chang conjunctival epithelial cells...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29622794/rab34-regulates-adhesion-migration-and-invasion-of-breast-cancer-cells
#20
Lixiang Sun, Xiaohui Xu, Yongjun Chen, Yuxia Zhou, Ran Tan, Hantian Qiu, Liting Jin, Wenyi Zhang, Rong Fan, Wanjin Hong, Tuanlao Wang
The small GTPase Rab34 regulates spatial distribution of the lysosomes, secretion, and macropinocytosis. In this study, we found that Rab34 is over-expressed in aggressive breast cancer cells, implying a potential role of Rab34 in breast cancer. Silencing Rab34 by shRNA inhibits cell migration, invasion, and adhesion of breast cancer cells. Rab34 specifically binds to the cytoplasmic tail of integrin β3, and depletion of Rab34 promotes the degradation of integrin β3. Interestingly, EGF induces the translocation of Rab34 to the membrane ruffle, which is greatly enhanced by the expression of Src kinase...
April 6, 2018: Oncogene
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