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Periodic paralysis

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https://www.readbyqxmd.com/read/28938080/dr-polio-revisiting-fdr-s-medical-legacy
#1
Robert G Dorfman, Asher Orkaby, Sukumar P Desai
The National Foundation for Infantile Paralysis (NFIP), the March of Dimes, and the Georgia Warm Springs Resort were reflections of Franklin D. Roosevelt's (FDR) complicated and personal relationship with polio. Between 1934 and 1957, significant advances were made in the care of polio survivors, and new and innovative medical fields gained both public attention and funding. The plight of disabled Americans and questions of accessibility also received widespread national attention. The NFIP helped establish a new prototype for grassroots philanthropy and personified FDR's vision for national health insurance...
September 22, 2017: Canadian Bulletin of Medical History, Bulletin Canadien D'histoire de la Médecine
https://www.readbyqxmd.com/read/28912873/phospholemman-a-major-regulator-of-skeletal-muscle-na-k-atpase-is-not-mutated-in-probands-with-hypokalemic-periodic-paralysis
#2
Ying-Ying Chen, Xiao-Ying Wang, Qiu-Xia Fu, Yi Kang, He-Bin Yao
The pathogenesis of hypokalemic periodic paralysis (HypoPP) remains unclear. Though some mutations in skeletal muscle ion channels were revealed previously, the exact mechanism remains to be fully elucidated. Increased Na(+)/K(+)-ATPase activity in skeletal muscle is postulated to contribute to attacks of HypoPP. Before the link between Na(+)/K(+)-ATPase dysfunction and these ion channel mutations is established, mutations in Na(+)/K(+)-ATPase and their regulators are the first to be excluded. Phospholemman, which is a protein encoded by the FXYD domain-containing ion transport regulator 1 (FXYD1) gene, is predominantly expressed in skeletal muscle and is the major regulator of Na(+)/K(+)-ATPase...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28899595/peripheral-nerve-pathology-at-fixed-stage-in-spinal-muscular-atrophy-with-respiratory-distress-type-1
#3
Azusa Ikeda, Sumimasa Yamashita, Yu Tsuyusaki, Mio Tanaka, Yukichi Tanaka, Akihiro Hashiguchi, Hiroshi Takashima, Tomohide Goto
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is characterized by severe respiratory failure due to diaphragmatic paralysis and distal muscular weakness in early infancy. After an initial decline in respiratory state and motor function until 1-2years of age, residual capabilities reach a plateau. We report the peripheral neuropathological findings of a patient with SMARD1 at 1year and 1month of age, when his muscle strength and respiratory symptoms had deteriorated and then stabilized for several months...
September 9, 2017: Brain & Development
https://www.readbyqxmd.com/read/28890753/introducing-an-accountability-framework-for-polio-eradication-in-ethiopia-results-from-the-first-year-of-implementation-2014-2015
#4
Aron Kassahun, Fiona Braka, Kathleen Gallagher, Aregai Wolde Gebriel, Peter Nsubuga, Pierre M'pele-Kilebou
INTRODUCTION: the World Health Organization (WHO), Ethiopia country office, introduced an accountability framework into its Polio Eradication Program in 2014 with the aim of improving the program's performance. Our study aims to evaluate staff performance and key program indicators following the introduction of the accountability framework. METHODS: the impact of the WHO accountability framework was reviewed after its first year of implementation from June 2014 to June 2015...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28890193/evaluating-cessation-of-the-type-2-oral-polio-vaccine-by-modeling-pre-and-post-cessation-detection-rates
#5
Steve J Kroiss, Michael Famulare, Hil Lyons, Kevin A McCarthy, Laina D Mercer, Guillaume Chabot-Couture
The globally synchronized removal of the attenuated Sabin type 2 strain from the oral polio vaccine (OPV) in April 2016 marked a major change in polio vaccination policy. This change will provide a significant reduction in the burden of vaccine-associated paralytic polio (VAPP), but may increase the risk of circulating vaccine-derived poliovirus (cVDPV2) outbreaks during the transition period. This risk can be monitored by tracking the disappearance of Sabin-like type 2 (SL2) using data from the polio surveillance system...
September 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28882539/multidimensional-effects-of-voice-therapy-in-patients-affected-by-unilateral-vocal-fold-paralysis-due-to-cancer
#6
Camila Barbosa Barcelos, Paula Angélica Lorenzon Silveira, Renata Lígia Vieira Guedes, Aline Nogueira Gonçalves, Luciana Dall'Agnol Siqueira Slobodticov, Elisabete Carrara-de Angelis
INTRODUCTION: Patients with unilateral vocal fold paralysis may demonstrate different degrees of voice perturbation depending on the position of the paralyzed vocal fold. Understanding the effectiveness of voice therapy in this population may be an important coefficient to define the therapeutic approach. OBJECTIVE: To evaluate the voice therapy effectiveness in the short, medium and long-term in patients with unilateral vocal fold paralysis and determine the risk factors for voice rehabilitation failure...
August 24, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28877511/severe-neurotoxicity-requiring-mechanical-ventilation-in-a-dog-envenomed-by-a-red-bellied-black-snake-pseudechis-porphyriacus-and-successful-treatment-with-an-experimental-bivalent-whole-equine-igg-antivenom
#7
A M Padula, E M Leister
Snakebite in dogs from Pseudechis porphyriacus (red-bellied black snake; RBBS) is a common envenomation treated by veterinarians in Australia where this snake occurs. This case report describes the successful treatment of a clinically severe RBBS envenomation in a dog with an experimental bivalent equine whole IgG antivenom and mechanical ventilation, following its presentation in a cyanotic state. The cause of the cyanosis and respiratory distress was considered due to paralysis from neurotoxins in RBBS venom...
September 4, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28870190/monobloc-implants-in-cementless-total-hip-arthroplasty-in-patients-with-legg-calve-perthes-disease-a-long-term-follow-up
#8
Ze-Yu Luo, Hao-Yang Wang, Duan Wang, Hui Pan, Fu-Xing Pei, Zong-Ke Zhou
BACKGROUND: The purpose of this study was to evaluate 10-year outcomes in cementless monobloc total hip arthroplasty (THA) in a group of hips with Legg-Calve-Perthes disease (LCPD). METHODS: We reviewed 71 patients (88 hips) who underwent cementless THA with a diagnosis of LCPD from 2003 to 2009. From the total of 71 patients, 34 men and 37 women with an average age of 49.94 years were included. The mean follow-up period was 10 years. RESULTS: The mean Harris Hip Score improved significantly from 46...
September 5, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28869050/long-term-voice-outcome-after-thyroidectomy-using-energy-based-devices
#9
Min Woo Park, Seung-Kuk Baek, Euy-Hyun Park, Kwang-Yoon Jung
OBJECTIVE: Voice dysfunction is frequently reported after thyroidectomy even in absence of vocal fold paralysis. The energy-based devices such as Harmonic scalpel (HS) or LigaSure (LS) are commonly used in conventional thyroidectomy. The objective of this study was to investigate the long-term voice outcome after total thyroidectomy using energy based devices. METHODS: Patients who underwent total thyroidectomy with or without central neck dissection for papillary thyroid carcinoma using HS or LS from April 2012 to March 2013 were involved...
August 28, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28857175/elevated-resting-h-current-in-the-r1239h-type-1-hypokalemic-periodic-paralysis-mutated-ca-2-channel
#10
Clarisse Fuster, Jimmy Perrot, Christine Berthier, Vincent Jacquemond, Bruno Allard
Missense mutations in the gene encoding the α1 subunit of the skeletal muscle voltage-gated Ca(2+) channel induce type 1 Hypokalemic Periodic Paralysis, a poorly understood neuromuscular disease characterized by episodic attacks of paralysis associated with low serum K(+) . The present study aimed at identifying the changes in muscle fibre electrical properties induced by acute expression of the R1239H Hypokalemic Periodic Paralysis human mutant α1 subunit of Ca(2+) channels in a mature muscle environment to better understand the pathophysiological mechanisms involved in this disorder...
August 30, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28844726/cycling-and-spinal-trauma-a-worrying-trend-in-referrals-to-a-national-spine-centre
#11
M P Broe, J C Kelly, P J Groarke, K Synnott, S Morris
INTRODUCTION: Cycling has seen a large increase in popularity worldwide over the last number of years. This has been linked to an increase in the number of road traffic accidents involving cyclists. Participation in cycling as part of competitive sport and endurance events has seen particular growth. AIM: To examine patients referred with spinal trauma related to cycling and to assess whether the growing popularity of cycling and particularly competitive cycling is linked to an increase in spinal trauma...
August 22, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28841083/hypokalaemia-periodic-paralysis
#12
Liam J Stapleton
Hypokalaemic periodic paralysis is a rare skeletal muscle channelopathy causing flaccid paralysis, which predominantly presents in adolescents and young adults. I report a case of a 33-year-old Caucasian man who presented with sudden onset paralysis, following previous similar presentations without investigation. Blood tests revealed undetectable serum potassium levels in the context of paralysis. Other causes of hypokalaemia were excluded, and the patient was treated with planned lifelong prophylactic potassium replacement for a diagnosis of primary hypokalaemic periodic paralysis...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28840670/-adult-experience-with-the-tibialis-posterior-transposition-to-the-center-of-the-foot-in-neuromuscular-disease
#13
P Parra-Téllez, H Jiménez-López, E López-Gavito, J Vázquez-Escamilla
The transfer of the posterior tibial tendon to the center of the dorsum of the foot is a method used to achieve dorsiflexion in flaccid paralysis of the anterolateral leg muscles or muscular imbalance of clubfoot. OBJECTIVE: To describe functional results back to the surgical procedure for transposition of posterior tibial the center of the foot. MATERIAL AND METHODS: The study design was observational, descriptive, transversal, ambispective with a description of the world of work patients with impaired dorsiflexora foot muscles and impaired gait in the period January 2008 to December 2014...
March 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28838168/disposing-of-excess-vaccines-after-the-withdrawal-of-oral-polio-vaccine
#14
Sarah Wanyoike, Alejandro Ramirez Gonzalez, Samantha B Dolan, Julie Garon, Chantal Laroche Veira, Lee M Hampton, Diana Chang Blanc, Manish M Patel
Until recently, waste management for national immunization programs was limited to sharps waste, empty vaccine vials, or vaccines that had expired or were no longer usable. However, because wild-type 2 poliovirus has been eradicated, the World Health Organization's (WHO's) Strategic Advisory Group of Experts on Immunization deemed that all countries must simultaneously cease use of the type 2 oral polio vaccine and recommended that all countries and territories using oral polio vaccine (OPV) "switch" from trivalent OPV (tOPV; types 1, 2, and 3 polioviruses) to bivalent OPV (bOPV; types 1 and 3 polioviruses) during a 2-week period in April 2016...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28831620/a-rabies-virus-vampire-bat-variant-shows-increased-neuroinvasiveness-in-mice-when-compared-to-a-carnivore-variant
#15
Leonardo Pereira Mesquita, Thais Helena Martins Gamon, Silvia Elena Campusano Cuevas, Karen Miyuki Asano, Willian de Oliveira Fahl, Keila Iamamoto, Karin Correa Scheffer, Samira Maria Achkar, Dennis Albert Zanatto, Cláudia Madalena Cabrera Mori, Paulo César Maiorka, Enio Mori
Rabies is one of the most important zoonotic diseases and is caused by several rabies virus (RABV) variants. These variants can exhibit differences in neurovirulence, and few studies have attempted to evaluate the neuroinvasiveness of variants derived from vampire bats and wild carnivores. The aim of this study was to evaluate the neuropathogenesis of infection with two Brazilian RABV street variants (variant 3 and crab-eating fox) in mice. BALB/c mice were inoculated with RABV through the footpad, with the 50% mouse lethal dose (LD50) determined by intracranial inoculation...
August 22, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28828366/sedation-and-neuromuscular-blocking-agents-in-acute-respiratory-distress-syndrome
#16
REVIEW
Jeremy Bourenne, Sami Hraiech, Antoine Roch, Marc Gainnier, Laurent Papazian, Jean-Marie Forel
Mechanical ventilation (MV) is the cornerstone of acute respiratory distress syndrome (ARDS) management. The use of protective ventilation is a priority in this acute phase of lung inflammation. Neuromuscular blocking agents (NMBAs) induce reversible muscle paralysis. Their use in patients with ARDS remains controversial but occurs frequently. NMBAs are used in 25-45% of ARDS patients for a mean period of 1±2 days. The main indications of NMBAs are hypoxemia and facilitation of MV. For ethical reasons, NMBA use is inseparable from sedation in the management of early ARDS...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28817551/progress-toward-poliomyelitis-eradication-afghanistan-january-2016-june-2017
#17
Maureen Martinez, Hemant Shukla, Joanna Nikulin, Mufti Zubair Wadood, Stephen Hadler, Chukwuma Mbaeyi, Rudolph Tangermann, Jaume Jorba, Derek Ehrhardt
Afghanistan, Pakistan, and Nigeria remain the only countries where the transmission of endemic wild poliovirus type 1 (WPV1) continues (1). This report describes polio eradication activities, progress, and challenges in Afghanistan during January 2016-June 2017 and updates previous reports (2,3). Thirteen WPV1 cases were confirmed in Afghanistan in 2016, a decrease of seven from the 20 cases reported in 2015. From January to June 2017, five WPV1 cases were reported, compared with six during the same period in 2016...
August 18, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28816829/treatment-outcome-of-metastatic-spine-tumor-in-lung-cancer-patients-did-the-treatments-improve-their-outcomes
#18
Hiroshi Uei, Yasuaki Tokuhashi, Masafumi Maseda
STUDY DESIGN: A retrospective, single-center study. OBJECTIVE: Investigation of the changes in the treatment outcomes of patients with lung cancer-derived metastatic spine tumors SUMMARY OF BACKGROUND DATA.: Metastatic spine tumors derived from lung cancer had been progressive, and their prognosis is poor. It has recently been reported that the use of molecularly targeted drugs and bone-modifying agents (BMA) improved the treatment outcomes of patients with lung cancer, but no detailed information about the treatment of metastatic spine tumors has been reported...
August 14, 2017: Spine
https://www.readbyqxmd.com/read/28798241/persisting-fatigue-and-myalgia-as-the-presenting-features-in-a-case-of-hypokalaemic-periodic-paralysis
#19
Matthew Thomas Neame, David Wright, Surendran Chandrasekaran
We report a case of a 9-year-old boy who developed hypokalaemic periodic paralysis (HypoPP) following a prodrome of persistent fatigue and muscle aches associated with mildly elevated creatine kinase (CK) levels.HypoPP is usually associated with a sudden onset of weakness and hypokalaemia at presentation. A review of published cases failed to identify any other reports of individuals with a similar onset of symptoms and elevated CK levels prior to the development of frank HypoPP.In the case described above, the association of these symptoms with elevated levels of CK may have been related to the underlying mutation in the skeletal muscle calcium channels that was subsequently identified...
August 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28797646/spinal-epidural-abscess-a-series-of-101-cases
#20
Martin Vakili, Nancy F Crum-Cianflone
BACKGROUND: Spinal epidural abscesses are uncommon but potentially devastating infections that often elude early diagnosis. An increasing incidence has been suggested; however, few contemporary data are available regarding risk factors and epidemiologic trends over time. METHODS: A retrospective study of spinal epidural abscesses from 2004 to 2014 at a large academic hospital was conducted. Cases were identified using ICD-9 code 324.1, and a review of medical and radiographic records was performed to confirm each case...
August 7, 2017: American Journal of Medicine
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