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https://www.readbyqxmd.com/read/29339763/glucocorticoid-receptor-gr%C3%AE-regulates-glucocorticoid-induced-ocular-hypertension-in-mice
#1
Gaurang C Patel, Yang Liu, J Cameron Millar, Abbot F Clark
Prolonged glucocorticoid (GC) therapy can cause GC-induced ocular hypertension (OHT), which if left untreated progresses to iatrogenic glaucoma and permanent vision loss. The alternatively spliced isoform of glucocorticoid receptor GRβ acts as dominant negative regulator of GR activity, and it has been shown that overexpressing GRβ in trabecular meshwork (TM) cells inhibits GC-induced glaucomatous damage in TM cells. The purpose of this study was to use viral vectors to selectively overexpress the GRβ isoform in the TM of mouse eyes treated with GCs, to precisely dissect the role of GRβ in regulating steroid responsiveness...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29336278/use-of-2015-beers-criteria-medications-by-older-medicare-beneficiaries
#2
Rajul Patel, Leona Zhu, Dilraj Sohal, Elena Lenkova, Nichole Koshki, Joseph Woelfel, Carly Ranson, Cynthia S Valle-Oseguera, Edward L Rogan
OBJECTIVE: To examine the prevalence of potentially inappropriate medications (PIMs) in community-dwelling Medicare beneficiaries based on the updated 2015 American Geriatrics Society Beers criteria. DESIGN: Cross-sectional study. SETTING: Thirteen mobile Medicare clinics were held throughout Northern and Central California during the fall of 2015. PATIENTS, PARTICIPANTS: Noninstitutionalized Medicare beneficiaries 65 years of age and older taking one or more medications...
January 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29303586/denaturants-alter-the-flux-through-multiple-pathways-in-the-folding-of-pdz-domain
#3
Zhenxing Liu, Dave Thirumalai
Although we understand many aspects of how small proteins (number of residues less than about hundred) fold, it is a major challenge to understand how large proteins self-assemble. To partially overcome this challenge, we performed simulations using the Self-Organized Polymer model with Side Chains (SOP-SC) in guanidinium chloride (GdmCl), using the Molecular Transfer Model (MTM), to describe the folding of the 110-residue PDZ3 domain. The simulations reproduce the folding thermodynamics accurately including the melting temperature (Tm), the stability of the folded state with respect to the unfolded state...
January 5, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29281854/macrotrabecular-massive-hepatocellular-carcinoma-a-distinctive-histological-subtype-with-clinical-relevance
#4
Marianne Ziol, Nicolas Poté, Giuliana Amaddeo, Alexis Laurent, Jean-Charles Nault, Frédéric Oberti, Charlotte Costentin, Sophie Michalak, Mohamed Bouattour, Claire Francoz, Georges Philippe Pageaux, Jeanne Ramos, Thomas Decaens, Alain Luciani, Boris Guiu, Valérie Vilgrain, Christophe Aubé, Jonathan Derman, Cécile Charpy, Jessica Zucman-Rossi, Nathalie Barget, Olivier Seror, Nathalie Ganne-Carrié, Valérie Paradis, Julien Calderaro
We recently identified a novel histological subtype of hepatocellular carcinoma, designated as "macrotrabecular-massive" (MTM-HCC) and associated with specific molecular features. In order to assess the clinical relevance of this novel variant, we aimed to investigate its prognostic value in two large series of patients with HCC treated either by surgical resection or radiofrequency ablation (RFA). We retrospectively included 237 HCC surgical samples and 284 HCC liver biopsies from patients treated by surgical resection and RFA, respectively...
December 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29281009/mtm-align-an-algorithm-for-fast-and-accurate-multiple-protein-structure-alignment
#5
Runze Dong, Zhenling Peng, Yang Zhang, Jianyi Yang
Motivation: As protein structure is more conserved than sequence during evolution, multiple structure alignment can be more informative than multiple sequence alignment, especially for distantly related proteins. With the rapid increase of the number of protein structures in the Protein Data Bank, it becomes urgent to develop efficient algorithms for multiple structure alignment. Results: A new multiple structure alignment algorithm (mTM-align) was proposed, which is an extension of the highly efficient pairwise structure alignment program TM-align...
December 21, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29233385/traditional-lecture-versus-jigsaw-learning-method-for-teaching-medication-therapy-management-mtm-core-elements
#6
Jennifer A Wilson, Angela H Pegram, Dawn M Battise, April M Robinson
BACKGROUND AND PURPOSE: To determine if traditional didactic lecture or the jigsaw learning method is more effective to teach the medication therapy management (MTM) core elements in a first year pharmacy course. EDUCATIONAL ACTIVITY AND SETTING: Traditional didactic lecture and a pre-class reading assignment were used in the fall semester cohort, and the jigsaw method was used in the spring semester cohort. Jigsaw is a cooperative learning strategy requiring students to assume responsibility for learning, and subsequently teaching peers...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233309/incorporating-the-american-pharmacists-association-s-delivering-medication-therapy-management-services-certificate-program-into-an-accelerated-pharmacy-curriculum
#7
Jennifer L Donovan, Jason Cross, Amanda M Morrill, Paul P Belliveau, Cheryl A Abel, Anna K Morin, Michael J Malloy
BACKGROUND AND PURPOSE: To describe the incorporation of the American Pharmacists Association (APhA) Delivering Medication Therapy Management (MTM) Services program into a PharmD curriculum and to describe student perceptions of the program. EDUCATIONAL ACTIVITY AND SETTING: The program was delivered over 12 months to students on two campuses via two didactic courses in the second professional year and during the first two advanced pharmacy practice experiences in the third professional year of an accelerated school of pharmacy program...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233271/know-your-medicine-a-novel-student-led-community-service-learning-program
#8
Crystal K Howell, Kelly R Reveles, Leroy C Knodel, Nancy R Pattyn, Christopher R Frei
INTRODUCTION: The objective of this article is to describe the efforts of the student pharmacist organization called Know Your Medicine (KYM) as they conduct medication therapy management (MTM) for older adults and underserved communities. METHODS: Patients brought medications, immunization records, and health concerns to KYM events during academic years 2012-2013 and 2013-2014. Student pharmacists performed health screenings, created personalized medication records (PMR), made recommendations, created personal action plans (PAP), and conducted follow-up phone calls...
May 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29228617/decreased-long-non-coding-rna-mtm-contributes-to-gastric-cancer-cell-migration-and-invasion-via-modulating-mt1f
#9
Zhenghua Lin, Sanchuan Lai, Xingkang He, Wei Zhuo, Lan Wang, Jianmin Si, Shujie Chen
The role of long non-coding RNAs (lncRNA) on gastric cancer (GC) are an emerging field. Here, we focused on a cancer-related lncRNA MTM and tried to explore its correlation with the development of GC. The expression of MTM was detected by qRT-PCR in GC cell lines and tissues. The relationship between MTM level and clinicopathological factors was then analyzed. Cell biological assays with overexpression or co-transfection approaches were examined to probe the functional relevance of this lncRNA and its potential targets...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221929/use-of-pharmacy-technicians-in-elements-of-medication-therapy-management-delivery-a-systematic-review
#10
REVIEW
Stephanie A Gernant, My-Oanh Nguyen, Sanna Siddiqui, Matthew Schneller
BACKGROUND: Documented barriers to Medication Therapy Management (MTM) delivery, such as limited time and inefficient workflow may be overcome by utilizing support staff for administrative services. However, it is unknown how pharmacy technicians have been historically utilized to assist pharmacists in MTM-delivery. OBJECTIVE: To characterize literature describing pharmacy technicians' participation in actions commonly undertaken in the provision of MTM services...
November 24, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29202159/mammographic-phantoms-frequently-used-to-determine-image-quality-a-comparative-study
#11
Khaled AlKhalifah, Ajit Brindabhan
Appropriate diagnosis depends on the image quality of the mammographic system. Phantoms are normally used, since they have physical properties similar to those of different human tissues, and are important tools for quality assurance of mammography equipment, evaluation of image quality, and accurate determination of patient dosage. The aim of this study was to evaluate various mammographic phantoms used to determine the image quality of digital mammographic equipment. METHODS: Three phantoms were used: an American College of Radiology accreditation phantom, an MTM 100/R, and a tissue-equivalent phantom...
2017: Journal of Allied Health
https://www.readbyqxmd.com/read/29183253/implementation-of-a-cardiac-transitions-of-care-pilot-program-a-prospective-study-of-inpatient-and-outpatient-clinical-pharmacy-services-for-patients-with-heart-failure-exacerbation-or-acute-myocardial-infarction
#12
Julie A Murphy, Michelle N Schroeder, Rachel E Rarus, Idris Yakubu, Sean O P McKee, Steven J Martin
BACKGROUND: Pharmacists may assist with reducing 30-day readmission rates for patients with heart failure (HF) exacerbation or acute myocardial infarction (AMI) by promoting medication adherence. OBJECTIVE: To determine the change in 30-day readmission rates for patients with HF exacerbation or AMI after implementation of a "high-touch" standard of care. METHODS: Patients admitted with HF exacerbation, non-ST-segment elevation AMI, or ST-segment elevation AMI from August 1, 2013, to June 30, 2015, were included in this prospective study...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29180545/implementation-of-a-standardized-medication-therapy-management-plus-approach-within-primary-care
#13
Emily J Schwartz, Jacques Turgeon, Jay Patel, Parag Patel, Hetal Shah, Amalia M Issa, Orsula V Knowlton, Calvin H Knowlton, Kevin T Bain
PURPOSE: The purpose of this study was to implement a clinical pharmacist-led medication therapy management (MTM) service within a primary-care setting that is enhanced by 1) a clinical decision support system (CDSS) that includes a unique combination of medication risk mitigation factors, which aids the pharmacist in interpreting the medication profile, and 2) pharmacogenomics (PGx) testing. METHODS: This was a service implementation study, whereby Medicare beneficiaries were eligible if they were patients of Elmwood Family Physicians, a private family, primary care practice with 2 locations in New Jersey, and were on at least 7 medications...
November 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29175479/methane-emissions-from-a-landfill-in-north-east-india-performance-of-various-landfill-gas-emission-models
#14
Muralidhar Gollapalli, Sri Harsha Kota
Rapid urbanization and economic growth has led to significant increase in municipal solid waste generation in India during the last few decades and its management has become a major issue because of poor waste management practices. Solid waste generated is deposited into open dumping sites with hardly any segregation and processing. Carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) are the major greenhouse gases that are released from the landfill sites due to the biodegradation of organic matter...
November 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29129668/characterization-of-actions-taken-during-the-delivery-of-medication-therapy-management-a-time-and-motion-approach
#15
Alice C Chang, Jutieh Lincoln, Wendy M Lantaff, Stephanie A Gernant, Heather A Jaynes, William Doucette, Margie E Snyder
OBJECTIVES: To characterize actions performed by pharmacists and support staff during provision of medication therapy management (MTM) and to compare actions performed according to practice characteristics. METHODS: A purposeful sample of 7 MTM practices (2 call centers and 5 community practices) was identified and visited by investigators. Pharmacists and support staff were observed during their routine provision of MTM. Investigators characterized "major" (e.g...
November 9, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29123366/new-approach-for-promoting-hpv-vaccination-in-college-men-based-on-multi-theory-model-mtm-of-health-behavior-change
#16
REVIEW
M Sharma, V K Nahar
No abstract text is available yet for this article.
September 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/29122201/factors-determining-workers-pace-while-conducting-continuous-sequential-lifting-carrying-and-lowering-tasks
#17
Yaar Harari, Raziel Riemer, Avital Bechar
To plan a new manual material handling work process, it is necessary to predict the times required to complete each task. Current time prediction models lack validity when the handled object's mass exceeds 2 kg. In this study, we investigated the effect of workplace design parameters on continuous sequential lifting, carrying, and lowering of boxes weighing from 2 kg to 14 kg. Both laboratory and field experiments were conducted. Results revealed that the box's weight and the lifting and lowering heights influenced the tasks' times...
February 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29083970/evaluating-patient-preferences-for-different-incentive-programs-to-optimize-pharmacist-provided-patient-care-program-enrollment
#18
Daniel Tomaszewski, Tim Cernohous, Rajiv Vaidyanathan
BACKGROUND: Employers have increased efforts to engage employees in health and wellness programs. Providing employees with incentives to participate in these programs has been shown to improve overall enrollment and engagement. One program that has had challenges with enrollment and engagement is medication therapy management (MTM). OBJECTIVES: To (a) determine how individuals evaluate different financial incentives to improve participation in an MTM program and (b) measure the effect of participant characteristics on incentive preference...
November 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29078707/continuous-care-provided-through-comprehensive-medication-management-in-an-acute-care-practice-model
#19
T David Marr, Nicole R Pinelli, Jamie A Jarmul, Kayla M Waldron, Stephen F Eckel, Jonathan D Cicci, Jill S Bates, Lindsey B Amerine
BACKGROUND: Pharmacy practice models that foster pharmacists' accountability for medication-related outcomes are imperative for the profession. Comprehensive medication management (CMM) is an opportunity to advance patient care. OBJECTIVE: The objective of this study was to evaluate the impact of a CMM practice model in the acute care setting on organizational, patient, and financial outcomes. METHODS: Three adult service lines focused on at-risk patients identified using internal risk stratification methodology were implemented...
October 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29071469/ultrastructural-analyses-of-internal-limiting-membrane-excised-from-highly-myopic-eyes-with-myopic-traction-maculopathy
#20
Reiji Yokota, Akito Hirakata, Nobutsugu Hayashi, Kazunari Hirota, Tosho Rii, Yuji Itoh, Tadashi Orihara, Makoto Inoue
PURPOSE: To evaluate the ultrastructure of the internal limiting membranes (ILMs) excised during vitrectomy from highly myopic eyes with myopic traction maculopathy (MTM). The clinical findings before and after the vitrectomy were compared. METHODS: Seven eyes of 7 patients with macular retinoschisis were studied. Four of these eyes also had a foveal detachment but without a retinal break. All the eyes underwent vitrectomy with the creation of a posterior vitreous detachment and ILM peeling...
October 25, 2017: Japanese Journal of Ophthalmology
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