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https://www.readbyqxmd.com/read/27898842/inferring-phenotypic-causal-structures-among-meat-quality-traits-and-the-application-of-a-structural-equation-model-in-japanese-black-cattle
#1
K Inoue, B D Valente, N Shoji, T Honda, K Oyama, G J M Rosa
Meat quality is one of the most important traits determining carcass price in the Japanese beef market. Optimized breeding goals and management practices for the improvement of meat quality traits requires knowledge regarding any potential functional relationships between them. In this context, the objective of this research was to infer phenotypic causal networks involving beef marbling score (BMS), beef color score (BCL), firmness of beef (FIR), texture of beef (TEX), beef fat color score (BFS), and the ratio of MUFA to SFA (MUS) from 11,855 Japanese Black cattle...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27832339/vitrectomy-and-scleral-imbrication-in-patients-with-myopic-traction-maculopathy-and-macular-hole-retinal-detachment
#2
Yoshimasa Ando, Akito Hirakata, Arisa Ohara, Reiji Yokota, Tadashi Orihara, Kazunari Hirota, Takashi Koto, Makoto Inoue
PURPOSE: To determine the outcomes of vitrectomy with scleral imbrication in highly myopic eyes with either myopic traction maculopathy (MTM) or macular hole retinal detachment (MHRD). METHODS: The medical records of 17 patients who had undergone vitrectomy with internal limiting membrane (ILM) peeling and scleral imbrication for MTM or MHRD were reviewed. The best-corrected visual acuities (BCVAs), the axial length, the macular hole (MH) closure rate, and the shape of the posterior segment determined by optical coherence tomography were evaluated...
November 10, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27825313/using-pharmacists-to-improve-risk-stratification-and-management-of-stage-3a-chronic-kidney-disease-a-feasibility-study
#3
Alex R Chang, Michael Evans, Christina Yule, Larissa Bohn, Amanda Young, Meredith Lewis, Elisabeth Graboski, Bethany Gerdy, William Ehmann, Jonathan Brady, Leah Lawrence, Natacha Antunes, Jamie Green, Susan Snyder, H Lester Kirchner, Morgan Grams, Robert Perkins
BACKGROUND: Measurement of albuminuria to stratify risk in chronic kidney disease (CKD) is not done universally in the primary care setting despite recommendation in KDIGO (Kidney Disease Improving Global Outcomes) guidelines. Pharmacist medication therapy management (MTM) may be helpful in improving CKD risk stratification and management. METHODS: We conducted a pragmatic, cluster-randomized trial using seven primary care clinic sites in the Geisinger Health System to evaluate the feasibility of pharmacist MTM in patients with estimated glomerular filtration rate (eGFR) 45-59 ml/min/1...
November 8, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27803501/medication-therapy-management-for-patients-receiving-oral-chemotherapy-agents-at-a-community-oncology-center-a-pilot-study
#4
Nathan S Bertsch, Ross J Bindler, Poppy L Wilson, Anne P Kim, Beverly Ward
Purpose: To determine the impact of a pharmacist-driven medication therapy management (MTM) program for patients receiving oral chemotherapy agents. Methods: We assessed the impact of MTM consultations with a pharmacist for patients who were receiving a new prescription for an oral chemotherapy agent. Data were assessed for outcomes including (1) number of medication errors identified in electronic medical records (EMRs), (2) number of interventions performed by the pharmacist, (3) time spent on the MTM process, and (4) patient satisfaction...
October 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27785167/pharmacists-perceptions-of-advancing-public-health-priorities-through-medication-therapy-management
#5
Lucas M Casserlie, Natalie A Dipietro Mager
BACKGROUND: Public health priorities can be addressed by pharmacists through channels such as medication therapy management (MTM) to optimize patient and population outcomes. However, no studies have specifically assessed pharmacists' perceptions of addressing public health priorities through MTM. OBJECTIVE: The objective of this study was to assess pharmacists' opinions regarding the feasibility and appropriateness of addressing seven areas of public health priority through MTM services to impact public health in direct patient care settings...
July 2016: Pharmacy Practice
https://www.readbyqxmd.com/read/27783550/impact-of-a-combined-value-based-insurance-design-and-medication-therapy-management-program-on-diabetes-medication-adherence
#6
Alex Peaslee, Marleen Wickizer, Julie Olson, Robert Topp
BACKGROUND: Value-based insurance design (VBID) waives or reduces prescription copayments in order to decrease member cost barriers to refilling medications. Medication therapy management (MTM) is a member clinical intervention designed to reinforce members' knowledge of their medications, which addresses barriers to medication adherence. Both methods have been shown to increase adherence in members, particularly when used in combination. To date, studies of such combined programs have often been completed within integrated health systems but have rarely included control populations...
November 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27765104/-mutant-rad50-enhances-killing-effects-of-radiation-on-nasopharyngeal-carcinoma-cell-line-cne1
#7
R C Yan, J Wang, Z Z Huang, Z Y Wang, X F Wu, J C Huang, L H Chang, D Q Li, G H Zhang
Objective: To investigate the killing effects of radiation and mutant Rad50 transfection on human nasopharyngeal carcinoma cell line CNE1. Methods: The experimental groups included: control group, Ad-Rad50-GFP group, Ad-EGFP group, irradiation group, Ad-Rad50-GFP combined with irradiation group, and Ad-EGFP combined with irradiation group. CNE1 cells were transfected with recombinant adenoviral vector Ad-Rad50-GFP carrying mutant Rad50 gene. The expressions of Mre11, Rad50, Nbs1, and relevant constituents composing MRN complex were detected by Western Blot...
October 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27750092/removal-of-carbamates-and-detoxification-potential-in-a-biomixture-fungal-bioaugmentation-versus-traditional-use
#8
Carlos E Rodríguez-Rodríguez, Karina Madrigal-León, Mario Masís-Mora, Marta Pérez-Villanueva, Juan Salvador Chin-Pampillo
The use of fungal bioaugmentation represents a promising way to improve the performance of biomixtures for the elimination of pesticides. The ligninolyitc fungus Trametes versicolor was employed for the removal of three carbamates (aldicarb, ALD; methomyl, MTM; and methiocarb, MTC) in defined liquid medium; in this matrix ALD and MTM showed similar half-lives (14d), nonetheless MTC exhibited a faster removal, with a half-life of 6.5d. Then the fungus was employed in the bioaugmentation of an optimized biomixture to remove the aforementioned carbamates plus carbofuran (CFN)...
October 14, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27743872/analytical-performance-bounds-for-multi-tensor-diffusion-mri
#9
Farid Ahmed Sid, Karim Abed-Meraim, Rachid Harba, Fatima Oulebsir-Boumghar
PURPOSE: To examine the effects of MR acquisition parameters on brain white matter fiber orientation estimation and parameter of clinical interest in crossing fiber areas based on the Multi-Tensor Model (MTM). MATERIAL AND METHODS: We compute the Cramér-Rao Bound (CRB) for the MTM and the parameter of clinical interest such as the Fractional Anisotropy (FA) and the dominant fiber orientations, assuming that the diffusion MRI data are recorded by a multi-coil, multi-shell acquisition system...
October 12, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27676212/racial-and-ethnic-disparities-in-meeting-mtm-eligibility-criteria-among-patients-with-asthma
#10
Degan Lu, Yanru Qiao, Karen C Johnson, Junling Wang
BACKGROUND: Asthma is one of the most frequently targeted chronic diseases in the medication therapy management (MTM) programs of the Medicare prescription drug (Part D) benefits. While racial and ethnic disparities in meeting eligibility criteria for MTM services have been reported, little is known about whether there would be similar disparities among adults with asthma in the United States. METHODS: Adult patients with asthma (age ≥18) from Medical Expenditure Panel Survey (2011-2012) were analyzed...
September 27, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27668439/navigating-medicare-part-d-websites-are-the-part-d-plans-in-compliance
#11
Catherine E Cooke, Michael J Kaiser, Monique A Sheppard, Nicole J Brandt
Today, more than one half of older adults use the internet to obtain health-related information, and there is growing interest from governmental agencies in providing information online. The Centers for Medicare & Medicaid Services (CMS) provides guidance to Part D prescription drug plan sponsors about information to include on their websites. The current article examines compliance with the 2014 CMS guidance for Medication Therapy Management (MTM) program information on Part D plan sponsors' websites. There were 59...
October 1, 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27629706/drosophila-neprilysins-are-involved-in-middle-term-and-long-term-memory
#12
Oriane Turrel, Aurélie Lampin-Saint-Amaux, Thomas Préat, Valérie Goguel
UNLABELLED: Neprilysins are type II metalloproteinases known to degrade and inactivate a number of small peptides. Neprilysins in particular are the major amyloid-β peptide-degrading enzymes. In mouse models of Alzheimer's disease, neprilysin overexpression improves learning and memory deficits, whereas neprilysin deficiency aggravates the behavioral phenotypes. However, whether these enzymes are involved in memory in nonpathological conditions is an open question. Drosophila melanogaster is a well suited model system with which to address this issue...
September 14, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27628159/cross-sectional-survey-of-perceived-barriers-among-community-pharmacists-who-do-not-immunize-in-wayne-county-michigan
#13
Sarah E Kelling, Anthony Pattin, Abdulbaset Salim, Paul Kilgore, Steven R Erickson
INTRODUCTION: The goal of the study was to identify perceived barriers to implementation of vaccination services encountered by independent and small-chain community pharmacies in an urban setting. METHODS: Pharmacists in independent and small-chain pharmacies located in 29 Michigan ZIP codes were visited and asked to complete a 5- to 10-min semi-structured interview. RESULTS: A total of 93 independent and 12 small-chain pharmacies participated (n = 105; 61%)...
September 15, 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27625743/impact-of-pharmacist-provided-medication-therapy-management-on-healthcare-quality-and-utilization-in-recently-discharged-elderly-patients
#14
Jordan D Haag, Amanda Z Davis, Robert W Hoel, Jeffrey J Armon, Laura J Odell, Ross A Dierkhising, Paul Y Takahashi
BACKGROUND: The optimization of medication use during care transitions represents an opportunity to improve overall health-related outcomes. The utilization of clinical pharmacists during care transitions has demonstrated benefit, although the optimal method of integration during the care transition process remains unclear. OBJECTIVE: To evaluate the impact of pharmacist-provided telephonic medication therapy management (MTM) on care quality in a care transitions program (CTP) for high-risk older adults...
July 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27607723/optical-modeling-and-optimizations-of-cu-sub-2-sub-znsnse-sub-4-sub-solar-cells-using-the-modified-transfer-matrix-method
#15
Dario Cozza, Carmen M Ruiz, David Duché, Sergio Giraldo, Edgardo Saucedo, Jean Jacques Simon, Ludovic Escoubas
The fast and computationally inexpensive Modified Transfer Matrix Method (MTM) is employed to simulate the optical response of kesterite Cu<sub>2</sub>ZnSnSe<sub>4</sub> solar cells. This method can partially take into account the scattering effects due to roughness at the interfaces between the layers of the stack. We analyzed the optical behavior of the whole cell structure by varying the thickness of the TCO layer (iZnO + ITO) between 50 and 1200 nm and the buffer CdS layer between 0 and 100 nm...
September 5, 2016: Optics Express
https://www.readbyqxmd.com/read/27587584/structures-of-mithramycin-analogues-bound-to-dna-and-implications-for-targeting-transcription-factor-fli1
#16
Caixia Hou, Stevi Weidenbach, Kristin E Cano, Zhonghua Wang, Prithiba Mitra, Dmitri N Ivanov, Jürgen Rohr, Oleg V Tsodikov
Transcription factors have been considered undruggable, but this paradigm has been recently challenged. DNA binding natural product mithramycin (MTM) is a potent antagonist of oncogenic transcription factor EWS-FLI1. Structural details of MTM recognition of DNA, including the FLI1 binding sequence GGA(A/T), are needed to understand how MTM interferes with EWS-FLI1. We report a crystal structure of an MTM analogue MTM SA-Trp bound to a DNA oligomer containing a site GGCC, and two structures of a novel analogue MTM SA-Phe in complex with DNA...
October 14, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27579257/using-multi-theory-model-to-predict-initiation-and-sustenance-of-small-portion-size-consumption-among-college-students
#17
Manoj Sharma, Hannah Priest Catalano, Vinayak K Nahar, Vimala Lingam, Paul Johnson, M Allison Ford
BACKGROUND: Consumption of large portion sizes is contributing to overweight and obesity.College students are a vulnerable group in this regard. The purpose of this study was to use multi-theory model (MTM) to predict initiation and sustenance of small portion size consumption in college students. METHODS: A total of 135 students at a large Southern US University completed a 35-item valid (face, content, and construct) and reliable (internally consistent) survey electronically in a cross-sectional design...
2016: Health Promotion Perspectives
https://www.readbyqxmd.com/read/27548528/pik3c2b-inhibition-improves-function-and-prolongs-survival-in-myotubular-myopathy-animal-models
#18
Nesrin Sabha, Jonathan R Volpatti, Hernan Gonorazky, Aaron Reifler, Ann E Davidson, Xingli Li, Nadine M Eltayeb, Claudia Dall'Armi, Gilbert Di Paolo, Susan V Brooks, Ana Buj-Bello, Eva L Feldman, James J Dowling
Myotubular myopathy (MTM) is a devastating pediatric neuromuscular disorder of phosphoinositide (PIP) metabolism resulting from mutations of the PIP phosphatase MTM1 for which there are no treatments. We have previously shown phosphatidylinositol-3-phosphate (PI3P) accumulation in animal models of MTM. Here, we tested the hypothesis that lowering PI3P levels may prevent or reverse the MTM disease process. To test this, we targeted class II and III PI3 kinases (PI3Ks) in an MTM1-deficient mouse model. Muscle-specific ablation of Pik3c2b, but not Pik3c3, resulted in complete prevention of the MTM phenotype, and postsymptomatic targeting promoted a striking rescue of disease...
September 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27478633/long-term-follow-up-of-the-fellow-eye-in-patients-undergoing-surgery-on-one-eye-for-treating-myopic-traction-maculopathy
#19
Hui-Juan Xia, Wei-Jun Wang, Feng'E Chen, Ying Wu, Zhen-Yuan Cai, Wei Chen, Su-Qin Yu, Ying Fan
Objective. To observe the fellow eye in patients undergoing surgery on one eye for treating myopic traction maculopathy. Methods. 99 fellow eyes of consecutive patients who underwent unilateral surgery to treat MTM were retrospectively evaluated. All patients underwent thorough ophthalmologic examinations, including age, gender, duration of follow-up, refraction, axial length, intraocular pressure, lens status, presence/absence of a staphyloma, and best-corrected visual acuity (BCVA). Fundus photographs and SD-OCT images were obtained...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27444147/reduction-of-the-spatially-mutual-coupling-between-dual-polarized-patch-antennas-using-coupled-metamaterial-slabs
#20
Bai Cao Pan, Wen Xuan Tang, Mei Qing Qi, Hui Feng Ma, Zui Tao, Tie Jun Cui
Mutual coupling inside antenna array is usually caused by two routes: signal leakage via conducting currents on the metallic background or surface wave along substrates; radio leakage received from space between antenna elements. The former one can be depressed by changing the distribution of surface currents, as reported in literatures. But when it comes to the latter one, the radiation-leakage-caused coupling, traditional approaches using circuit manipulation may be inefficient. In this article, we propose and design a new type of decoupling module, which is composed of coupled metamaterial (MTM) slabs...
2016: Scientific Reports
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