keyword
MENU ▼
Read by QxMD icon Read
search

digestive cancer

keyword
https://www.readbyqxmd.com/read/29353165/prognostic-value-of-primary-tumour-resection-in-synchronous-metastatic-colorectal-cancer-individual-patient-data-analysis-of-first-line-randomised-trials-from-the-arcad-database
#1
K L van Rooijen, Q Shi, K K H Goey, J Meyers, V Heinemann, E Diaz-Rubio, E Aranda, A Falcone, E Green, A de Gramont, D J Sargent, C J A Punt, M Koopman
Indication for primary tumour resection (PTR) in asymptomatic metastatic colorectal cancer (mCRC) patients is unclear. Previous retrospective analyses suggest a survival benefit for patients who underwent PTR. The aim was to evaluate the prognostic value of PTR in patients with synchronous mCRC by analysis of recent large RCTs including systemic therapy with modern targeted agents. Individual patient data (IPD) of 3423 patients enrolled into 8 randomised controlled trials (RCTs) with first-line systemic therapy in the ARCAD (Aide et Recherche en Cancérologie Digestive) database were analysed...
January 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29344855/protocol-for-the-analysis-of-laser-capture-microdissected-fresh-frozen-tissue-homogenates-by-silver-stained-1d-sds-page
#2
DaRue A Prieto, Gordon Whitely, Donald J Johann, Josip Blonder
The heterogeneity present in solid tumors adds significant difficulty to scientific analysis and improved understanding. Fundamentally, solid tumor formation consists of cancer cells proper along with stromal elements. The burgeoning malignant process is dependent upon modified stromal elements. Collectively, the stroma forms an essential microenvironment, which is indispensable for the survival and growth of the malignant neoplasm. This cellular heterogeneity makes molecular profiling of solid tumors via mass spectrometry (MS)-based proteomics a daunting task...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29344853/laser-microdissection-based-microproteomics-of-formalin-fixed-and-paraffin-embedded-ffpe-tissues
#3
Rémi Longuespée, Dominique Baiwir, Gabriel Mazzucchelli, Nicolas Smargiasso, Edwin De Pauw
Laser microdissection-based proteomics on formalin-fixed and paraffin-embedded tissues is usually performed from relatively large tissue areas or pools of multiple tissue pieces. However, several molecular pathology studies require working on very limited amounts of tissue. This is for example the case when very early cancer lesions have to be handled. Hereby, we present a method for the processing of very small pieces of formalin-fixed and paraffin-embedded tissues for proteomic purposes. This approach is designed in order to avoid sample loss during technical processing and to optimize the digestion of tissue areas containing as little as 2700 cells...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29344287/role-of-mir-483-in-digestive-tract-cancers-from-basic-research-to-clinical-value
#4
REVIEW
Wei Zhou, Wanli Yang, Jiaojiao Ma, Hongwei Zhang, Zeng Li, Lei Zhang, Jinqiang Liu, Zhenyu Han, Hu Wang, Liu Hong
Digestive tract cancers (DTCs) is the most common malignant tumors in the world. Despite surgery and medical technology have witnessed the increasing development and sharp advancement in the past decade, DTCs remain a critical concern with high morbidity and mortality. Since a class of small noncoding RNAs termed miRNAs were identified several years ago, increasing studies have attempted to illustrate the relationship between the specific miRNAs dysregulated expression levels and the diseases phenotypic changes...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29333020/oxaliplatin-induced-peripheral-neuropathy-in-south-indian-cancer-patients-a-prospective-study-in-digestive-tract-cancer-patients
#5
Sreenivasulu Palugulla, Steven Aibor Dkhar, Smita Kayal, Sunil K Narayan
Purpose: The aim of the current study is to report our prospective experience on the prevalence of oxaliplatin-induced peripheral neuropathy (OXAIPN) in patients with digestive tract cancers treated with oxaliplatin-based combination therapy. Materials and Methods: A total of 219 patients scheduled to be treated with oxaliplatin-based combination therapy were prospectively examined at baseline and follow-up during the therapy between November 2014 and December 2016...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29331883/curative-distal-pancreatectomy-in-patients-with-acinar-cell-carcinoma-of-pancreas-diagnosed-by-endoscopic-aspiration-via-esophago-jejunostomy-a-successful-case-report
#6
Takeomi Hamada, Atsushi Nanashima, Masahide Hiyoshi, Makoto Ikenoue, Naoya Imamura, Koichi Yano, Yoshiro Fujii, Yoshimasa Kubota, Tesshin Ban, Hiroshi Kawakami, Yuichiro Sato
INTRODUCTION: This is a case report on the advances in preoperative endoscopic-guided fine-needle-aspiration (FNA) diagnosis for pancreatic carcinoma to achieve a curative operation even in patients who have a history of total gastrectomy. CASE PRESENTATION: A 65-year-old man, who underwent total gastrectomy for gastric cancer 13 years ago, had discomfort in the left lateral abdomen. A 3-cm hypovascular mass accompanying a large distal pseudocyst in the pancreatic tail was observed on computed tomography...
January 8, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29330806/fluorescence-activated-cell-sorting-of-murine-mammary-cancer-stem-like-cell-subpopulations-with-hif-activity
#7
Danielle L Brooks, Tiffany N Seagroves
Fluorescence-activated cell sorting (FACS) is a common method to identify and to isolate subpopulations within a complex mixture of cells based on their light scatter and fluorescent staining profiles. FACS is widely used to enrich for normal tissue and tumor cells that have stem cell potential. Whereas FACS protocols using conventional breast cancer cell lines are relatively routine, additional technical challenges are encountered when sorting for cell populations from freshly digested solid tumors, particularly for use in downstream cancer stem cell (CSC) assays...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29328489/antibody-nanoparticle-conjugate-constructed-with-trastuzumab-and-nanoparticle-albumin-bound-paclitaxel-for-targeted-therapy-of-human-epidermal-growth-factor-receptor%C3%A2-2-positive-gastric-cancer
#8
Jian Xiong, Shuhua Han, Shuang Ding, Jingchao He, Haijun Zhang
Gastric cancer (GC) is the most lethal malignancy in the digestive system. This study investigated an antibody-nanoparticle conjugate (ANC) constructed with trastuzumab (Herceptin®) and nanoparticle albumin-bound paclitaxel (nab-paclitaxel, Abraxane®) (trastuzumab/nab‑paclitaxel) as a novel strategy of targeted therapy for human epidermal growth factor receptor 2 (HER2) positive GC. The ANC was fabricated with trastuzumab and nab‑paclitaxel by a 'one-step' synthesis using EDC/NHS. In vitro antitumor efficacy was evaluated by cell viability, apoptosis rate and cell cycle of HER2-positive GC NCI‑N87 cells and compared with paclitaxel (Taxol®), nab‑paclitaxel and trastuzumab/nab‑paclitaxel...
January 9, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29328433/peiminine-serves-as-an-adriamycin-chemosensitizer-in-gastric-cancer-by-modulating-the-egfr-fak-pathway
#9
Qianqian Tang, Yunfei Wang, Lanjing Ma, Meiling Ding, Tingyu Li, Yongzhan Nie, Zhengyi Gu
Gastric cancer (GC) is one of the most common malignancies of the digestive tract. Adriamycin (ADR) has been widely utilized in various chemotherapy regimens for treating GC, yet its long-term application may increase drug resistance resulting in treatment failure. Increasing evidence shows that bioactive natural products can be used as chemotherapeutic sensitizers that can significantly improve chemotherapy sensitivity. Peiminine (PMI) is a biologically active component extracted from Fritillaria walujewii Regel...
January 3, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29318540/identification-of-proteolytic-cleavage-sites-of-epha2-by%C3%A2-membrane-type-1-matrix-metalloproteinase-on-the%C3%A2-surface-of-cancer-cells
#10
Keiji Kikuchi, Hiroko Kozuka-Hata, Masaaki Oyama, Motoharu Seiki, Naohiko Koshikawa
Proteolytic cleavage of membrane proteins can alter their functions depending on the cleavage sites. We recently demonstrated that membrane type 1 matrix metalloproteinase (MT1-MMP ) converts the tumor suppressor EphA2 into an oncogenic signal transducer through EphA2 cleavage. The cleaved EphA2 fragment that remains at the cell surface may be a better target for cancer therapy than intact EphA2. To analyze the cleavage site(s) of EphA2, we purified the fragments from tumor cells expressing MT1-MMP and Myc- and 6× His-tagged EphA2 by two-step affinity purification ...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29317469/u-shaped-association-between-fertility-and-mortality-in-a-community-based-sample-of-japanese-women
#11
Shoko Konishi, Chris Fook Sheng Ng, Chiho Watanabe
BACKGROUND: Prospective cohort studies of contemporary populations in both Western and Asian settings have reported a U-shaped association between fertility and mortality. We examined whether an association exists between fertility and all-cause and cause-specific mortality in a sample of Japanese women. METHODS: A prospective cohort study was conducted in one rural and one urban community in Gunma Prefecture, Japan, in 1993. A follow-up survey was conducted in the year 2000 in 4858 women aged 47-77 years, and information on demographic and lifestyle characteristics was collected...
January 9, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29316709/screaming-body-and-silent-healthcare-providers-a-case-study-with-a-childhood-sexual-abuse-survivor
#12
REVIEW
Sigrun Sigurdardottir, Sigridur Halldorsdottir
Stressful early life experiences cause immune dysregulation across the lifespan. Despite the fact that studies have identified childhood sexual abuse (CSA) survivors as a particularly vulnerable group, only a few attempts have been made to study their lived-experience of the physical health consequences of CSA. The aim of this study was to explore a female CSA survivor's lived-experience of the physical health consequences of CSA and how she experienced the reactions of healthcare providers. Seven interviews were conducted with this 40-year-old woman, Anne, using a phenomenological research approach...
January 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29315597/american-cranberries-and-health-benefits-an-evolving-story-of-25-years
#13
REVIEW
Shaomin Zhao, Haiyan Liu, Liwei Gu
Cranberries contain various type of bioactive components. Scientists have been studying cranberries' beneficial effects on urinary tract health since the 20th century. Entering the 21st century, the protection of cranberry phytochemicals against cancer and vascular diseases has drawn more attention from researchers. Anthocyanins, procyanidins, and flavonols in cranberries were all documented to have potential effects on cancer prevention. The cardiometabolic effects of cranberries have been investigated in several clinical trials...
January 9, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29315013/on-the-evolution-of-bile-salts-and-the-farnesoid-x-receptor-in-vertebrates
#14
Kim Frisch, Aage Kristian Olsen Alstrup
In recent decades, our knowledge of bile salts has undergone a vast development, and bile salts are now known not only for their detergent properties that aid in the absorption of dietary lipids but also for their interaction with specific nuclear and membrane receptors. In particular, it has been realized that the response of the farnesoid X receptor (FXR) to bile acids provides a signal bridge between the liver and small intestine, controlling the intracellular levels, biosynthesis, and enterohepatic circulation of bile acids...
March 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29312644/systematic-review-and-meta-analysis-of-the-prognostic-value-of-cxcr2-in-solid-tumor-patients
#15
Yong Yang, Baoyang Luo, Yong An, Han Sun, Huihua Cai, Donglin Sun
CXC chemokine receptor-2 (CXCR2) expression is associated with the prognosis of multiple cancers. We performed a meta-analysis to determine the association between the CXCR2 expression in tumor tissue and patient prognosis. We compiled related literature from PubMed, Embase, and Web of Science (last updated July 31, 2017). A total of 4012 patients with solid tumors from 21 studies were included to evaluate the association between CXCR2 and overall survival, recurrence-free survival, or disease-free survival...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29312585/increased-risk-of-brain-cancer-incidence-in-stroke-patients-a-clinical-case-series-population-based-and-longitudinal-follow-up-study
#16
Chih-Wei Chen, Tain-Junn Cheng, Chung-Han Ho, Jhi-Joung Wang, Shih-Feng Weng, Ya-Chin Hou, Hung-Chi Cheng, Chung-Ching Chio, Yan-Shen Shan, Wen-Tsan Chang
Stroke and brain cancer are two distinct diseases. However, the relationship between both diseases has rarely been examined. This study investigated the longitudinal risk for developing brain cancer in stroke patients. To study this, we first reviewed the malignant gliomas previously with or without stroke using brain magnetic resonance imaging (MRI) images and the past histories. Two ischemic stroke patients before the malignant glioma were identified and belonged to the glioblastoma mutiforme (GBM). Particularly, both GBM specimens displayed strong hypoxia-inducible factor 1α (HIF-1α) expression in immunohistochemical (IHC) staining...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311165/night-shift-work-increases-the-risks-of-multiple-primary-cancers-in-women-a-systematic-review-and-meta-analysis-of-61-articles
#17
REVIEW
Xia Yuan, Chenjing Zhu, Manni Wang, Fei Mo, Wei Du, Xuelei Ma
A growing number of studies have examined associations between night shift work and the risks of common cancers among women, with varying conclusions. We did a meta-analysis to identify whether long-term night shift work increased the risks of common cancers in women. We enrolled 61 articles involving 114,628 cases and 3,909,152 participants from Europe, North America, Asia, and Australia. Risk estimates were performed with a random-effect model or a fixed-effect model. Subgroup analyses and meta-regression analyses about breast cancer were conducted to explore possible sources of heterogeneity...
January 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29308636/triple-signal-amplification-strategy-for-ultrasensitive-determination-of-mirna-based-on-duplex-specific-nuclease-and-bridge-dna-gold-nanoparticles
#18
Bing Bo, Tian Zhang, Yiting Jiang, Haiyan Cui, Peng Miao
Abnormal expression of miRNAs always occurs in solid tumors. Thus, it is critical to sensitively and selectively detect such biomarkers for the diagnosis and prognosis of diseases. Here we report a biosensing scheme for the determination of miRNA with triple signal amplification based on target-triggered cyclic duplex specific nuclease digestion and bridge DNA-gold na-noparticles. Electrochemical signals are recorded to present initial levels of miRNA. This method is ultrasensitive with a wide linear range of 10-17 to 10-11 M...
January 8, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29300750/prognostic-value-of-pretreatment-albumin-globulin-ratio-in-digestive-system-cancers-a-meta-analysis
#19
Hui-Wen Guo, Tang-Zhan Yuan, Jia-Xi Chen, Yang Zheng
The albumin/globulin ratio (AGR) has been widely reported to be a potential predictor of prognosis in digestive system cancers (DSCs), but convincing conclusions have not been made. Therefore, herein, we performed a meta-analysis of relevant studies regarding this topic to evaluate the prognostic value of AGR in patients with DSCs. Three databases, including PubMed, EMBase, and Web of science, were searched comprehensively for eligible studies through September 8, 2017. The outcomes of interest included overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS)...
2018: PloS One
https://www.readbyqxmd.com/read/29298512/protective-effect-of-safflower-seed-on-cisplatin-induced-renal-damage-in-mice-via-oxidative-stress-and-apoptosis-mediated-pathways
#20
Chan Hum Park, Ah Young Lee, Ji Hyun Kim, Su Hui Seong, Gwi Yeong Jang, Eun Ju Cho, Jae Sue Choi, Jungkee Kwon, Young Ock Kim, Sang Won Lee, Takako Yokozawa, Yu Su Shin
Cisplatin, a platinum chelate with potent antitumor activity against cancers of the testis, ovary, urinary bladder, prostate, and head and neck, has adverse effects on the kidney, bone marrow, and digestive organs, and its use is particularly limited by nephropathy as a side effect. In the present study, safflower seed extract was administered to a mouse model of cisplatin-induced acute renal failure to investigate its activity. Cisplatin (20[Formula: see text]mg/kg body weight) was administered by intraperitoneal injection to mice that had received oral safflower seed extract (100 or 200[Formula: see text]mg/kg body weight per day) for the preceding 2 days...
January 3, 2018: American Journal of Chinese Medicine
keyword
keyword
29319
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"