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https://www.readbyqxmd.com/read/27920485/use-of-the-endocuff-during-routine-colonoscopy-examination-improves-adenoma-detection-a-meta-analysis
#1
Matthew Chin, William Karnes, M Mazen Jamal, John G Lee, Robert Lee, Jason Samarasena, Matthew L Bechtold, Douglas L Nguyen
AIM: To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy. METHODS: Scopus, Cochrane databases, MEDLINE/PubMed, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy (EAC) to standard colonoscopy, for any indication, were included in the analysis...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27917872/advances-in-the-study-of-berberine-and-its-derivatives-a-focus-on-anti-inflammatory-and-anti-tumor-effects-in-the-digestive-system
#2
REVIEW
Kun Zou, Zhao Li, Yong Zhang, Hao-Yue Zhang, Bo Li, Wei-Liang Zhu, Ji-Ye Shi, Qi Jia, Yi-Ming Li
It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic with a long history. Over the past decade, many reports have demonstrated that this natural product and its derivatives have high activity against both cancer and inflammation...
December 5, 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27911932/chemical-and-cellular-assays-combined-with-in-vitro-digestion-to-determine-the-antioxidant-activity-of-flavonoids-from-chinese-bayberry-myrica-rubra-sieb-et-zucc-leaves
#3
Yu Zhang, Shiguo Chen, Chaoyang Wei, Hui Gong, Lanqi Li, Xingqian Ye
Oxidative stress is highly associated with the development of cardiovascular diseases and cancer and has drawn great attention. Natural products suggest a potential role in prevention of these disorders. The aim of this study was to investigate the antioxidant and anti-cancer properties of Chinese bayberry leaves (Myrica rubra Sieb. et Zucc.) flavonoids (BLF) comprehensively through the combination of in vitro digestion, chemical and cellular antioxidant assays. Based on the LC/MS data, the major flavonoids of BLF were myricitrin and quercetin 3-rhamnoside...
2016: PloS One
https://www.readbyqxmd.com/read/27911869/paclitaxel-oxaliplatin-fluorouracil-tof-regimen-versus-s-1-oxaliplatin-sox-regimen-for-metastatic-gastric-cancer-patients
#4
Xichao Dai, Xizhi Zhang, Chaomin Wang, Jingting Jiang, Changping Wu
AIMS AND BACKGROUND: This study was designed to compare the efficacy and safety of paclitaxel/oxaliplatin/fluorouracil (TOF) regimen and S-1/oxaliplatin (SOX) regimen for metastatic gastric cancer (GC) patients. METHODS: Sixty patients were divided into TOF group and SOX groups randomly. Patients in the TOF group received paclitaxel (135 mg/m2 iv) on day 1, oxaliplatin (100 mg/m2 iv) on day 1, fluorouracil (500 mg/m2 continuous iv) on day 1-5. The patients in the SOX group received oxaliplatin (130 mg/m2 iv) on day 1 and S-1 (40 mg~60mg orally twice/day based on body surface area) on days 1-14...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27909239/affinity-of-indocyanine-green-in-the-detection-of-colorectal-peritoneal-carcinomatosis-the-role-of-enhanced-permeability-and-retention-effect
#5
Alexandre Filippello, Jack Porcheron, Jean Philippe Klein, Michèle Cottier, Gabriele Barabino
Indocyanine green (ICG) is increasingly being used in digestive oncology. In colorectal cancer, ICG can be used to detect lymph node metastasis and hepatic metastasis on the surface of the liver. In peritoneal carcinomatosis, it was previously suspected that the diffusion of ICG in the tumor mass was due to the enhanced permeability and retention effect; however, this phenomenon has not been clearly demonstrated. Using bevacizumab, an antibody directed against vascular endothelial growth factor that consequently inhibits neoangiogenesis, we sought to confirm the mode of ICG diffusion...
November 30, 2016: Surgical Innovation
https://www.readbyqxmd.com/read/27906434/effect-and-mechanism-of-par-2-on-the-proliferation-of-esophageal-cancer-cells
#6
D Quanjun, Z Qingyu, Z Qiliang, X Liqun, C Jinmei, L Ziquan, H Shike
OBJECTIVE: Esophageal Cancer (EC) is a common malignant tumor occurred in the digestive tract. In this study, we investigated the mechanism of Protease Activated Receptor 2 (PAR-2) on the proliferation of esophageal cancer cell. MATERIALS AND METHODS: Transfected esophageal cancer (EC) cell (PAR-2shRNA EC109) was established with low stable PAR-2 expression. EC109 cell was treated with PAR-2 agonist, PAR-2 anti-agonist and MAPK inhibitor respectively; Untreated EC109 cell (blank control) and PAR-2shRNA EC109 cell were used for analysis also...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27906137/in-vitro-toxicity-of-carbon-nanotube-polylysine-colloids-to-colon-cancer-cells
#7
Alejandro Ansón-Casaos, Laura Grasa, Desirée Pereboom, José Emilio Mesonero, Alvaro Casanova, María Divina Murillo, María Teresa Martínez
Single-walled carbon nanotubes (SWCNTs) are thoroughly purified and dispersed in an aqueous solution of high molecular weight poly-L-lysine (pLlys). Human intestinal epithelial Caco-2/TC7 cells are incubated with the SWCNT dispersions in pLlys, and their effects on cell viability are studied by image flow cytometry. No significant changes are observed in the cell culture wells up to pLlys concentrations of 10 μg ml(-1). However, high mortality is detected at pLlys concentrations of 100 μg ml(-1). The presence of oxygen-free SWCNTs does not modify the effects of pLlys on cell cultures at any of the tested concentrations (≤1 μg ml(-1))...
December 2016: IET Nanobiotechnology
https://www.readbyqxmd.com/read/27903892/methylation-sensitive-enrichment-of-minor-dna-alleles-using-a-double-strand-dna-specific-nuclease
#8
Yibin Liu, Chen Song, Ioannis Ladas, Mariana Fitarelli-Kiehl, G Mike Makrigiorgos
Aberrant methylation changes, often present in a minor allelic fraction in clinical samples such as plasma-circulating DNA (cfDNA), are potentially powerful prognostic and predictive biomarkers in human disease including cancer. We report on a novel, highly-multiplexed approach to facilitate analysis of clinically useful methylation changes in minor DNA populations. Methylation Specific Nuclease-assisted Minor-allele Enrichment (MS-NaME) employs a double-strand-specific DNA nuclease (DSN) to remove excess DNA with normal methylation patterns...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27900614/trends-in-published-meta-analyses-in-cancer-research-2008-2013
#9
Ximena V Qadir, Mindy Clyne, Tram Kim Lam, Muin J Khoury, Sheri D Schully
In order to capture trends in the contribution of epidemiology to cancer research, we describe an online meta-analysis database resource for cancer clinical and population research and illustrate trends and descriptive detail of cancer meta-analyses from 2008 through 2013. A total of 4,686 cancer meta-analyses met our inclusion criteria. During this 6-year period, a fivefold increase was observed in the yearly number of meta-analyses. Fifty-six percent of meta-analyses concerned observational studies, mostly of cancer risk, more than half of which were genetic studies...
November 29, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27895742/comparative-analysis-of-gene-expression-profiles-of-gastric-cardia-adenocarcinoma-and-gastric-non-cardia-adenocarcinoma
#10
Bin Song, Juan Du, Neng Deng, Ji-Chen Ren, Zhen-Bo Shu
In the present study, gene expression profiles were analyzed to identify the molecular mechanisms underlying gastric cardia adenocarcinoma (GCA) and gastric non-cardia adenocarcinoma (GNCA). A gene expression dataset (accession number GSE29272) was downloaded from Gene Expression Omnibus, and consisted of 62 GCA samples and 62 normal controls, as well as 72 GNCA samples and 72 normal controls. The two groups of differentially-expressed genes (DEGs) were compared to obtain common and unique DEGs. A differential analysis was performed using the Linear Models for Microarray Data package in R...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895416/practice-guidelines-for-the-pathological-diagnosis-of-primary-liver-cancer-2015-update
#11
REVIEW
Wen-Ming Cong, Hong Bu, Jie Chen, Hui Dong, Yu-Yao Zhu, Long-Hai Feng, Jun Chen, Guideline Committee
In 2010, a panel of Chinese pathologists reported the first expert consensus for the pathological diagnosis of primary liver cancers to address the many contradictions and inconsistencies in the pathological characteristics and diagnostic criteria for PLC. Since then considerable clinicopathological studies have been conducted globally, prompting us to update the practice guidelines for the pathological diagnosis of PLC. In April 18, 2014, a Guideline Committee consisting of 40 specialists from seven Chinese Societies (including Chinese Society of Liver Cancer, Chinese Anti-Cancer Association; Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Pathology, Chinese Anti-Cancer Association; Digestive Disease Group, Chinese Society of Pathology, Chinese Medical Association; Chinese Society of Surgery, Chinese Medical Association; Chinese Society of Clinical Oncology, Chinese Anti-Cancer Association; Pathological Group of Hepatobiliary Tumor and Liver Transplantation, Chinese Society of Pathology, Chinese Medical Association) was created for the formulation of the first guidelines for the standardization of the pathological diagnosis of PLC, mainly focusing on the following topics: gross specimen sampling, concepts and diagnostic criteria of small hepatocellular carcinoma (SHCC), microvascular invasion (MVI), satellite nodules, and immunohistochemical and molecular diagnosis...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27893668/outcome-of-endoscopy-negative-iron-deficiency-anemia-in-patients-above-65-a-longitudinal-multicenter-cohort
#12
Raphaël Clere-Jehl, Erik Sauleau, Stefan Ciuca, Mickael Schaeffer, Amanda Lopes, Bernard Goichot, Thomas Vogel, Georges Kaltenbach, Eric Bouvard, Jean-Louis Pasquali, Daniel Sereni, Emmanuel Andres, Anne Bourgarit
After the age of 65 years, iron deficiency anemia (IDA) requires the elimination of digestive neoplasia and is explored with upper and lower gastrointestinal (GI) endoscopy. However, such explorations are negative in 14% to 37% of patients. To further evaluate this issue, we evaluated the outcomes of patients aged over 65 years with endoscopy-negative IDA.We retrospectively analyzed the outcomes of in-patients over the age of 65 years with IDA (hemoglobin <12 g/dL and ferritin <70 μg/L) who had negative complete upper and lower GI endoscopies in 7 tertiary medical hospitals...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27890867/obesity-related-digestive-diseases-and-their-pathophysiology
#13
REVIEW
Su Youn Nam
Obesity is a growing medical and public health problem worldwide. Many digestive diseases are related to obesity. In this article, the current state of our knowledge of obesity-related digestive diseases, their pathogenesis, and the medical and metabolic consequences of weight reduction are discussed. Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett's esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma, gallstone, cholangiocarcinoma, and pancreatic cancer...
November 29, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27888861/inflammatory-bowel-disease-in-digestive-disease-week-2016-advances-in-epidemiology-follow-up-treatment-monitoring-optimisation-and-individual-tailoring-and-colon-cancer-prevention
#14
Santiago García-López
In Digestive Disease Week 2016, interesting data were presented on the eventual role of certain foods in inflammatory bowel disease, although the value of these data is relative. Also of interest were epidemiological studies, of which several analysed the natural history of the disease. Some presentations dealt with the search for individual predictive factors, a pressing need in clinical practice. Unfortunately, some of the findings presented were of dubious value. A study suggesting that a simple parameter as increased blood monocytes could be a clear predictive factor of poor outcome could perhaps be highlighted (the results were striking but had multiple limitations)...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27888808/prognostic-nutritional-index-as-a-prognostic-biomarker-for-survival-in-digestive-system-carcinomas
#15
Yang Zhao, Peng Xu, Huafeng Kang, Shuai Lin, Meng Wang, Pengtao Yang, Cong Dai, Xinghan Liu, Kang Liu, Yi Zheng, Zhijun Dai
The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta-analysis. A lower PNI was significantly associated with the shorter overall survival (OS) [Hazard Ratio (HR) 1.83, 95% Confidence Interval (CI) 1.62-2.07], the poorer disease-free survival (DFS) (HR 1...
November 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27888332/interaction-of-gut-microbiota-with-bile-acid-metabolism-and-its-influence-on-disease-states
#16
REVIEW
Christopher Staley, Alexa R Weingarden, Alexander Khoruts, Michael J Sadowsky
Primary bile acids serve important roles in cholesterol metabolism, lipid digestion, host-microbe interactions, and regulatory pathways in the human host. While most bile acids are reabsorbed and recycled via enterohepatic cycling, ∼5% serve as substrates for bacterial biotransformation in the colon. Enzymes involved in various transformations have been characterized from cultured gut bacteria and reveal taxa-specific distribution. More recently, bioinformatic approaches have revealed greater diversity in isoforms of these enzymes, and the microbial species in which they are found...
November 25, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27884752/quantitative-proteomic-analysis-reveals-that-proteins-required-for-fatty-acid-metabolism-may-serve-as-diagnostic-markers-for-gastric-cancer
#17
Zhen Jiang, Hongchun Shen, Bo Tang, Qin Yu, Xingli Ji, Li Wang
BACKGROUND: Gastric cancer is one of the leading causes of cancer-related deaths worldwide. The sensitivities and specificities of current biomarkers for gastric cancer are insufficient for clinical detection, and new diagnostic tests are therefore urgently required. METHODS: A discovery set of gastric cancer and adjacent normal tissues were analyzed for differentially expressed proteins by labeling of peptide digests with isobaric tag for relative and absolute quantitation (iTRAQ) reagents followed by liquid chromatography-electrospray ionization-tandem mass spectrometry...
November 21, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27881522/prevalence-of-papillomavirus-in-brazil-a-systematic-review-protocol
#18
Verônica Colpani, Augusto Bacelo Bidinotto, Maicon Falavigna, Silvana Pereira Giozza, Adele Schwartz Benzaken, Cristina Pimenta, Ana Goretti Kalume Maranhão, Carla Magda Allan Santos Domingues, Luciano Serpa Hammes, Eliana M Wendland
INTRODUCTION: Human papillomavirus (HPV) infection is a cause of premalignant and malignant cancer in the lower genital and digestive tracts. In Brazil, there have been no prevalence studies that included a nationwide sample, and the prevalence of HPV has not been determined in many regions. METHODS: We will search the EMBASE, LILACS, MEDLINE, Web of Science and SciELO databases and previously published review articles to identify original research articles assessing HPV prevalence of the perineal (cervical, penile and anal) and oral areas...
November 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27881356/-correlation-analysis-of-g870a-ccnd1-gene-polymorphism-with-digestive-system-tumors
#19
Shu-Min Yang, Ya-Lin Shi
OBJECTIVE: To study the correlation of G870A CCND1 gene polymorphism and digestive system tumors. METHODS: From August 2010 to August 2014, 164 digestive system cancer patients (including 82 patients with gastric cancer and 82 with colorectal cancer) and 82 healthy subjects (control group) were examined with PCR-restriction fragment length polymorphism (PCR-RFLP). The distribution of CCND1 gene G870A frequency in the 3 groups and its association with tumor staging and grading were analyzed...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27880017/comparison-of-the-outcomes-of-free-jejunal-flap-reconstructions-of-pharyngoesophageal-defects-in-hypopharyngeal-cancer-and-corrosive-injury-patients
#20
Mu-Han Hsieh, Yun-Tai Yang, Yueh-Ju Tsai, Yur-Ren Kuo, Pao-Yuan Lin
INTRODUCTION: Free jejunal flap is one of the optimal choices for restoring upper digestive tract. The purpose of this study was to introduce the treatment strategies and to compare the outcomes of free jejunal flap for pharyngoesophageal reconstruction between hypopharyngeal cancer and chemical corrosive injured esophagus. METHODS: From 2001 to 2012, patients who had been received esophageal reconstruction by free jejunal flap for pharyngoesophageal defect were divided into squamous cell carcinoma (SCC) group and corrosive chemical injury (CCI) group...
November 23, 2016: Microsurgery
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