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Spectral domain optical coherence tomography

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https://www.readbyqxmd.com/read/29156649/short-term-choriocapillaris-changes-in-patients-with-central-serous-chorioretinopathy-after-half-dose-photodynamic-therapy
#1
Marco Nassisi, Carlo Lavia, Camilla Alovisi, Luca Musso, Chiara M Eandi
BACKGROUND: Although photodynamic therapy (PDT) has become the standard treatment for central serous chorioretinopathy (CSC), its mechanism of action remains unclear. It is assumed that PDT induces short-term choriocapillaris (CC) occlusion and long-term choroidal vascular remodeling. In this paper, we describe the short-term CC changes induced by Half-Dose PDT (HD-PDT) in chronic CSC using optical coherence tomography-angiography (OCTA). METHODS: This is a prospective interventional case series...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29155795/in-vivo-imaging-of-cx3cr1gfp-gfp-reporter-mice-with-spectral-domain-optical-coherence-tomography-and-scanning-laser-ophthalmoscopy
#2
Despina Kokona, Joël Jovanovic, Andreas Ebneter, Martin S Zinkernagel
Spectral domain optical coherence tomography (SD-OCT) and scanning laser ophthalmoscopy (SLO) are extensively used in experimental ophthalmology. In the present protocol, mice expressing green fluorescent protein (gfp) under the promoter of Cx3cr1 (BALB/c-Cx3cr1(gfp/gfp)) were used to image microglia cells in vivo in the retina. Microglia are resident macrophages of the retina and have been implicated in several retinal diseases(1)(,)(2)(,)(3)(,)(4)(,)(5)(,)(6). This protocol provides a detailed approach for generation of retinal B-scans, with SD-OCT, and imaging of microglia cell distribution in Cx3cr1(gfp/gfp) mice with SLO in vivo, using an ophthalmic imaging platform system...
November 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155698/bull-s-eye-maculopathy-with-mutations-in-rds-prph2-and-rom-1
#3
Juliet O Essilfie, Christian J Sanfilippo, David Sarraf
PURPOSE: To report a case of bull's eye maculopathy associated with mutations in RDS/PRPH2 and ROM-1 genes. METHODS: We present a case report of a patient with a characteristic maculopathy and describe the multimodal retinal imaging findings including spectral domain optical coherence tomography and fundus autofluorescence and full-field electrophysiology. The results of genetic testing are also reported. RESULTS: A 60-year-old woman presented with decreased vision and a remarkable bull's eye maculopathy with retinal examination...
November 16, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29152163/effect-of-aging-and-lifestyle-on-photoreceptors-and-retinal-pigment-epithelium-cross-sectional-study-in-a-healthy-danish-population
#4
Jacob Harris, Yousif Subhi, Torben L Sørensen
Photoreceptors and their supporting retinal pigment epithelium constitute the key functional parts of the retina. Here, a study was undertaken to show how aging and lifestyle factors affect the photoreceptor layer and the retinal pigment epithelium and Bruch's membrane complex (RPE-BM) in vivo in a healthy Danish population using spectral-domain optical coherence tomography. This was a cross-sectional study of healthy humans aged ≥50 years. All participants were interviewed for medical history and lifestyle factors...
2017: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/29148032/secondary-glaucoma-in-uveitis-comparison-of-the-optic-nerve-head-morphology-among-a-nonmydriatic-fundus-camera-hrt-and-sd-oct
#5
Milena Pahlitzsch, Matthias K J Klamann, Saskia Jacob, Carl Erb, Sibylle Winterhalter, Necip Torun, Anna-Karina B Maier, Eckart Bertelmann
PURPOSE: To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a nonmydriatic fundus camera, confocal laser scanning ophthalmoscopy (HRT3), and spectral-domain optical coherence tomography (SD-OCT) in uveitic glaucoma. METHODS: A total of 59 patients with uveitic glaucoma (21 female, 38 male; mean age 56.8 ± 18.7 years) were included in this prospective cross-sectional study. All patients were measured by the Kowa Nonmyd WX 3D camera (2D/3D nonmydriatic retinal camera, Kowa Company), the HRT3 (Heidelberg Engineering), and SD-OCT (Carl Zeiss Meditec) by one examiner on the same day...
November 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29148030/incidence-and-quantitative-analysis-of-dissociated-optic-nerve-fiber-layer-appearance-real-loss-of-retinal-nerve-fiber-layer
#6
Yoon J Kim, Kyoung S Lee, Soo G Joe, June-Gone Kim
PURPOSE: To assess the association between appearance of dissociated optic nerve fiber layer (DONFL) after internal limiting membrane (ILM) peeling and changes in the macular nerve fiber layer (NFL) area by spectral-domain optical coherence tomography (SD-OCT). METHODS: This study included 132 consecutive patients who had successfully undergone vitrectomy with ILM peeling for idiopathic epiretinal membrane or macular holes and had been followed up for ≥6 months...
November 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29140735/factors-associated-with-visual-acuity-in-patients-with-cystoid-macular-oedema-and-retinitis-pigmentosa
#7
Gerald Liew, Anthony T Moore, Patrick D Bradley, Andrew R Webster, Michel Michaelides
PURPOSE: Retinitis pigmentosa is the most common inherited retinal dystrophy. The factors associated with visual acuity in patients with other retinal diseases are well known, but are poorly understood in patients with retinitis pigmentosa. This knowledge is useful for prognosis and to support secondary endpoints in clinical trials. METHODS: We conducted a cross-sectional study of consecutive patients recruited from the inherited retinal disease service from January 2012 to December 2012...
November 15, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29138978/-morphology-of-the-vitreoretinal-interface-in-fellow-eyes-of-patients-with-full-thickness-macular-holes
#8
J E Klaas, S Burzer, S Abraham, N Feucht, C P Lohmann, M Maier
PURPOSE: We performed a retrospective, observational clinical study to evaluate the vitreoretinal interface (VRI) in fellow eyes of patients with full thickness macular holes (FTMH) based on spectral domain optical coherence tomography (SD-OCT) examinations. METHODS: The VRI in fellow eyes of 38 patients with idiopathic FTMH, 6 of which had concomitant vitreomacular traction (VMT) and the VRI of 32 patients with FTMH with complete resolution of VMT were examined by SD-OCT for the presence of vitreomacular adhesion (VMA), VMT and the formation of FTMH, lamellar macular holes (LMH), macular pseudoholes (MPH) or epiretinal membranes (ERM)...
November 14, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29138527/longitudinal-analysis-of-mouse-sdoct-volumes
#9
Bhavna J Antony, Aaron Carass, Andrew Lang, Byung-Jin Kim, Donald J Zack, Jerry L Prince
Spectral-domain optical coherence tomography (SDOCT), in addition to its routine clinical use in the diagnosis of ocular diseases, has begun to find increasing use in animal studies. Animal models are frequently used to study disease mechanisms as well as to test drug efficacy. In particular, SDOCT provides the ability to study animals longitudinally and non-invasively over long periods of time. However, the lack of anatomical landmarks makes the longitudinal scan acquisition prone to inconsistencies in orientation...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29135802/panretinal-photocoagulation-versus-ranibizumab-for-proliferative-diabetic-retinopathy-comparison-of-peripapillary-retinal-nerve-fiber-layer-thickness-in-a-randomized-clinical-trial
#10
Lee M Jampol, Isoken Odia, Adam R Glassman, Carl W Baker, Anjali M Bhorade, Dennis P Han, Glenn J Jaffe, Michele Melia, Neil M Bressler, Angelo P Tanna
PURPOSE: Compare changes in retinal nerve fiber layer (RNFL) thickness between eyes assigned to intravitreous ranibizumab or panretinal photocoagulation and assess correlations between changes in RNFL and visual field sensitivity and central subfield thickness. METHODS: Eyes with proliferative diabetic retinopathy were randomly assigned to ranibizumab or panretinal photocoagulation. Baseline and annual follow-up spectral domain optical coherence tomography RNFL imaging, optical coherence tomography macular imaging, and automated static perimetry (Humphrey visual field 60-4 algorithm) were performed...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29135703/a-case-of-relapsing-retinal-pigment-epithelial-detachment-in-peripapillary-pachychoroid-pigment-epitheliopathy
#11
Fuyan Zhang, Yuxing Qiu, Jay M Stewart
PURPOSE: To report the findings in a patient with peripapillary pachychoroid pigment epitheliopathy who demonstrated a retinal pigment epithelial detachment (PED) that was present at some times but not other times. METHODS: A review of 24 months of the clinical course and findings on multimodal imaging, including color fundus photography, fundus autofluorescence, spectral domain optical coherence tomography, and enhanced depth imaging optical coherence tomography...
November 10, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29133640/evaluation-of-spectral-domain-optical-coherence-tomography-parameters-in-ocular-hypertension-preperimetric-and-early-glaucoma
#12
Tuğba Aydogan, BetÜl İlkay Sezgin Akçay, Esra Kardeş, Ahmet Ergin
PURPOSE: The objective of this study is to evaluate the diagnostic ability of retinal nerve fiber layer (RNFL), macular, optic nerve head (ONH) parameters in healthy subjects, ocular hypertension (OHT), preperimetric glaucoma (PPG), and early glaucoma (EG) patients, to reveal factors affecting the diagnostic ability of spectral domain-optical coherence tomography (SD-OCT) parameters and risk factors for glaucoma. METHODS: Three hundred and twenty-six eyes (89 healthy, 77 OHT, 94 PPG, and 66 EG eyes) were analyzed...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29131902/choroidal-thickness-in-and-outside-of-vascular-arcade-in-healthy-eyes-using-spectral-domain-optical-coherence-tomography
#13
Jae Yong Park, Bum Gi Kim, Je Hyung Hwang, Jae Suk Kim
Purpose: To study the distribution of choroidal thickness (CT) in and outside of the vascular arcade, as well as at the fovea in healthy eyes using spectral-domain optical coherence tomography (OCT). Methods: Seventy healthy eyes were examined with OCT to obtain nine horizontal lines in and outside of the vascular arcade. Nine points including the central point of the line were chosen in 0.5-mm intervals to calculate CT. CT was measured at a total of 81 points in each patient to construct a map of CT distribution...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29131901/comparison-of-foveal-macular-and-peripapillary-intraretinal-thicknesses-between-autism-spectrum-disorder-and-neurotypical-subjects
#14
José Javier García-Medina, María García-Piñero, Mónica Del-Río-Vellosillo, Jesarán Fares-Valdivia, Ana Belén Ragel-Hernández, Salvador Martínez-Saura, María Dolores Cárcel-López, Vicente Zanon-Moreno, María Dolores Pinazo-Duran, María Paz Villegas-Pérez
Purpose: To compare thicknesses of intraretinal layers segmented by spectral-domain optical coherence tomography (SD-OCT) between autism spectrum disorder (ASD) and neurotypical (NT) individuals. Methods: We performed 2 scans on 108 eyes from 54 participants (27 high-functioning ASD and 27 age- and sex-matched NT subjects): macular fast volume and peripapillary retinal nerve fiber layer (pRNFL). Macula was automatically segmented. The mean foveal and macular thickness of nine different layers and the thickness of nine pRNFL sectors were considered...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29131051/interocular-symmetry-of-choroidal-thickness-and-volume-in-healthy-eyes-on-optical-coherence-tomography
#15
Elvira Orduna, Ana Sanchez-Cano, Maria José Luesma, Itziar Perez-Navarro, Emilio Abecia, Isabel Pinilla
BACKGROUND: We aimed to determine the physiological symmetry, with spectral-domain optical coherence tomography, of choroidal measurements in a healthy population in all the areas defined in the Early Treatment Diabetic Retinopathy Study (ETDRS). METHODS: One hundred and fifty-four eyes of 77 healthy young adults between the ages of 19 and 32 years were enrolled. Differences in choroidal thickness (CT) and volume (CV) between the left and right eyes were calculated...
November 10, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29126757/quantifying-the-rate-of-ellipsoid-zone-loss-in-stargardt-disease
#16
Cindy X Cai, Jacob G Light, James T Handa
PURPOSE: To determine a reliable method of using the ellipsoid zone (EZ) on optical coherence tomography (OCT) to track disease progression in Stardgardt disease (STGD). DESIGN: retrospective reliability study METHODS: STGD patients with genetically confirmed ABCA4 gene mutations seen at the Wilmer Eye Institute with follow-up visits separated by at least 12 months were identified. Spectral domain optical coherence tomography (SD-OCT) macula volume scans centered at the fovea and fundus autofluorescence (FAF) images were obtained...
November 7, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29125422/characteristics-of-morphologic-macular-abnormalities-in-neuroimmunology-practice
#17
Omar Al-Louzi, Elias S Sotirchos, Angela Vidal-Jordana, Shin C Beh, Julia Button, Howard S Ying, Laura J Balcer, Elliot M Frohman, Shiv Saidha, Peter A Calabresi, Scott D Newsome
BACKGROUND: Morphologic macular abnormalities (MMAs) are frequently seen on macular optical coherence tomography (OCT) imaging in neuroimmunology practice, yet studies pragmatically assessing prevalence and risk factors of MMAs to date are limited. OBJECTIVE: To describe the characteristics of MMAs in a neuroimmunology-based academic practice. METHODS: Cross-sectional study of 1450 patients (2900 eyes) who underwent spectral-domain macular OCT between June 2010 and June 2012...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29125012/optical-assessment-of-the-in-vivo-tympanic-membrane-status-using-a-handheld-optical-coherence-tomography-based-otoscope
#18
Kibeom Park, Nam Hyun Cho, Mansik Jeon, Sang Heun Lee, Jeong Hun Jang, Stephen A Boppart, Woonggyu Jung, Jeehyun Kim
OBJECTIVE: Conventional otoscopes and oto-endoscopes, which are used to examine the tympanic membrane (TM), do not provide tomographic information. Optical coherence tomography (OCT) non-invasively reveals the depth-resolved internal microstructure of the TM with very high spatial resolution. We designed this study to examine the TMs with middle ear diseases using a handheld otoscope employing 860 nm spectral domain (SD)-OCT, combined with video camera and to demonstrate the clinical applicability of this system...
November 10, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29121358/optical-coherence-tomography-findings-in-endogenous-fungal-chorioretinitis-retinitis-and-endophthalmitis
#19
John D Stephens, Murtaza K Adam, Bohzo Todorich, Lisa J Faia, Sunir Garg, James P Dunn, Sonia Mehta
BACKGROUND AND OBJECTIVE: To describe spectral-domain optical coherence tomography (SD-OCT) findings in eyes with endogenous fungal chorioretinitis and endophthalmitis. PATIENTS AND METHODS: Retrospective, observational case series of subjects at Wills Eye Hospital and William Beaumont Hospital were identified by screening OCT billing data and cross-referencing with patient charts. Clinical and imaging data were collected for each patient and reviewed. RESULTS: Twelve eyes of seven consecutive patients were identified, demonstrating two patterns of posterior ocular involvement: chorioretinal infiltration and superficial retinal/retinal vascular infiltration without choroidal involvement...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29120977/use-of-a-scan-ultrasound-and-optical-coherence-tomography-to-differentiate-papilledema-from-pseudopapilledema
#20
Roberto Saenz, Han Cheng, Thomas C Prager, Laura J Frishman, Rosa A Tang
SIGNIFICANCE: Differentiating papilledema from pseudopapilledema reflecting tilted/crowded optic discs or disc drusen is critical but can be challenging. Our study suggests that spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness and retrobulbar optic nerve sheath diameter (ONSD) measured by A-scan ultrasound provide useful information when differentiating the two conditions. PURPOSE: To evaluate the use of A-scan ultrasound and spectral-domain OCT retinal nerve fiber layer thickness (RNFLT) in differentiating papilledema associated with idiopathic intracranial hypertension from pseudopapilledema...
November 9, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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