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Ganglion cell complex

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https://www.readbyqxmd.com/read/28650925/quantitative-analysis-of-the-inner-retinal-layer-thicknesses-in-age-related-macular-degeneration-using-corrected-optical-coherence-tomography-segmentation
#1
Ilkay Kilic Muftuoglu, Hema L Ramkumar, Dirk-Uwe Bartsch, Amit Meshi, Raouf Gaber, William R Freeman
PURPOSE: To characterize inner retinal damage in patients with dry age-related macular degeneration (AMD) using high-resolution spectral domain optical coherence tomography images. METHODS: Sixty eyes of 60 patients with AMD were categorized using the Age-Related Eye Disease Study (AREDS) severity scale. Spectral domain optical coherence tomography images of these patients were quantified by manually correcting the segmentation of each retinal layer, including the retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer to ensure accurate delineation of layers...
June 23, 2017: Retina
https://www.readbyqxmd.com/read/28650878/leber-hereditary-optic-neuropathy-bridging-the-translational-gap
#2
Neringa Jurkute, Patrick Yu-Wai-Man
PURPOSE OF REVIEW: Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA (mtDNA) genetic disorder in the population. We address the clinical evolution of the disease, the secondary etiological factors that could contribute to visual loss, and the challenging task of developing effective treatments. RECENT FINDINGS: LHON is characterized by a preclinical phase that reflects retinal ganglion cell (RGC) dysfunction before rapid visual deterioration ensues...
June 24, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28631244/optical-coherence-tomography-angiography-in-pre-perimetric-open-angle-glaucoma
#3
Gilda Cennamo, Daniela Montorio, Nunzio Velotti, Federica Sparnelli, Michele Reibaldi, Giovanni Cennamo
PURPOSE: To evaluate the diagnostic efficacy of optical coherence tomography (OCT) angiography, in patients with pre-perimetric open-angle glaucoma. METHODS: Thirty-eight consecutive eyes of 26 patients with pre-perimetric open-angle glaucoma and 48 normal eyes of 32 controls were included in this prospective study. We evaluated OCT angiography, spectral-domain OCT and visual fields parameters. Differences between controls and patients and between OCT angiography parameters and traditional glaucoma measurements were evaluated...
June 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28628662/quantitative-analysis-of-retinal-layers-on-three-dimensional-spectral-domain-optical-coherence-tomography-for-pituitary-adenoma
#4
Min Sun, Zhiqiang Zhang, Chiyuan Ma, Suihua Chen, Xinjian Chen
PURPOSE: To quantitatively investigate the characteristics of eyes with pituitary adenoma presented by three-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) using three common indices, including thickness, optical intensity ratio, and optical intensity attenuation coefficient (OIAC). METHODS: The SD-OCT database of 38 patients with pituitary adenoma and 39 normal controls were included in the study. Quadrantal and average measurements of thickness, optical intensity ratio, and OIAC were calculated for macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL) combined with inner plexiform layer (IPL) (GCIPL) and/or the collective ganglion cell complex (GCC)...
2017: PloS One
https://www.readbyqxmd.com/read/28624323/post-receptor-neuronal-loss-in-intermediate-age-related-macular-degeneration
#5
Enrico Borrelli, Nizar Saleh Abdelfattah, Akihito Uji, Muneeswar Gupta Nittala, David S Boyer, SriniVas R Sadda
PURPOSE: To investigate the relationship between ganglion cell complex (GCC) thickness and photoreceptor alterations in eyes with intermediate age-related macular degeneration (AMD). DESIGN: Retrospective case-control study. METHODS: We collected data from 68 eyes with intermediate AMD from 68 patients with spectral domain optical coherence tomography (SD-OCT) imaging. A control group of 50 eyes from 50 healthy subjects was included for comparison...
June 14, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28617659/inhibitory-interneurons-in-the-retina-types-circuitry-and-function
#6
Jeffrey S Diamond
Visual signals in the vertebrate retina are shaped by feedback and feedforward inhibition in two synaptic layers. In one, horizontal cells establish fundamental center-surround receptive-field properties via morphologically and physiologically complex synapses with photoreceptors and bipolar cells. In the other, a panoply of amacrine cells imbue ganglion cell responses with spatiotemporally complex information about the visual world. Here, I review current ideas about horizontal cell signaling, considering the evidence for and against the leading, competing theories...
June 15, 2017: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28596752/the-retina-in-multiple-system-atrophy-systematic-review-and-meta-analysis
#7
REVIEW
Carlos E Mendoza-Santiesteban, Iñigo Gabilondo, Jose Alberto Palma, Lucy Norcliffe-Kaufmann, Horacio Kaufmann
BACKGROUND: Multiple system atrophy (MSA) is a rare, adult-onset, rapidly progressive fatal synucleinopathy that primarily affects oligodendroglial cells in the brain. Patients with MSA only rarely have visual complaints, but recent studies of the retina using optical coherence tomography (OCT) showed atrophy of the peripapillary retinal nerve fiber layer (RNFL) and to a lesser extent the macular ganglion cell layer (GCL) complex. METHODS: We performed a literature review and meta-analysis according to the preferred reporting items for systematic reviews and meta-analyses guidelines for studies published before January 2017, identified through PubMed and Google Scholar databases, which reported OCT-related outcomes in patients with MSA and controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28584914/optical-coherence-tomography-for-the-diagnosis-and-monitoring-of-idiopathic-intracranial-hypertension
#8
Philipp Albrecht, Christine Blasberg, Marius Ringelstein, Ann-Kristin Müller, David Finis, Rainer Guthoff, Ella-Maria Kadas, Wolf Lagreze, Orhan Aktas, Hans-Peter Hartung, Friedemann Paul, Alexander U Brandt, Axel Methner
The objectives of the study were to investigate the value of optical coherence tomography in detecting papilledema in patients with idiopathic intracranial hypertension (IIH), a disease which is difficult to monitor and which can lead to permanent visual deficits; to analyze retinal changes over time. In this non-interventional case-control study, spectral-domain optical coherence tomography (SD-OCT) was used to analyze the retinal and optic nerve head (ONH) morphology of 21 patients with IIH and 27 age- and sex-matched healthy controls over time...
June 5, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28580408/data-on-the-association-of-the-nuclear-envelope-protein-sun1-with-nucleoli
#9
Ossama Moujaber, Nawal Omran, Mohamed Kodiha, Brigitte Pié, Ellis Cooper, John F Presley, Ursula Stochaj
SUN proteins participate in diverse cellular activities, many of which are connected to the nuclear envelope. Recently, the family member SUN1 has been linked to novel biological activities. These include the regulation of nucleoli, intranuclear compartments that assemble ribosomal subunits. We show that SUN1 associates with nucleoli in several mammalian epithelial cell lines. This nucleolar localization is not shared by all cell types, as SUN1 concentrates at the nuclear envelope in ganglionic neurons and non-neuronal satellite cells...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28580173/sesn2-gene-ablation-enhances-susceptibility-to-gentamicin-induced-hair-cell-death-via-modulation-of-ampk-mtor-signaling
#10
Eliane Ebnoether, Alessia Ramseier, Maurizio Cortada, Daniel Bodmer, Soledad Levano-Huaman
The process of gentamicin-induced hair cell damage includes the activation of oxidative stress processes. Sestrins, as stress-responsive proteins, protect cells against oxidative stress. Sestrins, particularly Sestrin-2, suppress excessive reactive oxygen species (ROS) accumulation and inhibit mammalian target of rapamycin complex 1 (mTORC1). Thus, we addressed the role of Sestrin-2 in the regulation of sensory hair cell survival after gentamicin exposure. Here, we show that Sestrins were expressed in the inner ear tissues, and Sestrin-2 immunolocalized in sensory hair cells and spiral ganglion (SG)...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28574419/effect-of-intravitreal-ranibizumab-on-ganglion-cell-complex-and-peripapillary-retinal-nerve-fiber-layer-in-neovascular-age-related-macular-degeneration-using-spectral-domain-optical-coherence-tomography
#11
Ilaria Zucchiatti, Maria V Cicinelli, Maurizio Battaglia Parodi, Luisa Pierro, Marco Gagliardi, Agostino Accardo, Francesco Bandello
PURPOSE: To analyze the changes in ganglion cell complex and peripapillary retinal nerve fiber layer thickness, in central macular thickness and choroidal thickness on spectral domain optical coherence tomography in patients with neovascular age-related macular degeneration treated with intravitreal ranibizumab injections. METHODS: All consecutive patients with untreated neovascular age-related macular degeneration received loading phase of three monthly intravitreal ranibizumab, followed by retreatments on a pro re nata protocol for 12 months...
July 2017: Retina
https://www.readbyqxmd.com/read/28574396/complex-heavy-metal-salts-effect-on-ganglion-nuclei-neurons-morphological-functions-in-adult-male-rats-cerebellar-cortex
#12
N Grintsova, N Glushchenko, M Dunaeva
In order to analyze the dynamics of morphological and morphometric nuclear rearrangements of cortical cerebellar Purkinje cells under prolonged exposure (for 90 days) on the body of copper sulfate, zinc and iron experiment was conducted on 48 white adult male rats weighing 200-250g, aged 5 -8 months. We used anatomic, morphometric, statistical and common methods of micro anatomical research method. It was found that the combined effect of copper sulfate, zinc and iron on the body has nuclear device ganglion neurons in the cerebellar cortex sufficiently expressive toxicity, which affects the state of neurons...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28567618/ganglion-cell-loss-in-early-glaucoma-as-assessed-by-photopic-negative-response-pattern-electroretinogram-and-spectral-domain-optical-coherence-tomography
#13
Barbara Cvenkel, Maja Sustar, Darko Perovšek
PURPOSE: To evaluate discrimination ability of pattern electroretinography (PERG) and photopic negative response (PhNR) between early glaucoma and healthy controls, and their relationship with structural measurements using spectral-domain optical coherence tomography (SD-OCT). METHODS: Cross-sectional study with 34 patients with ocular hypertension (n = 7), suspect glaucoma (n = 17), and early glaucoma (n = 10), plus 24 age-matched controls. The following parameters were analyzed: P50 and N95 amplitude of the PERG, PhNR amplitude and PhNR/b-wave ratio, peripapillary retinal and macular nerve fiber layer (NFL) thicknesses, and ganglion cell complex (GCC) thickness...
May 31, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28557829/progressive-decrease-of-peripapillary-angioflow-vessel-density-during-structural-and-visual-field-progression-in-early-primary-open-angle-glaucoma
#14
Gábor Holló
PURPOSE: To present a case of early primary open-angle glaucoma in which retinal nerve fiber layer thickness (RNFLT), ganglion cell complex (GCC), and visual field progression were accompanied with significant progression of peripapillary angioflow vessel density (PAFD) measured with optical coherence tomographic angiography. METHODS: A 68-year-old female patient who was under topical intraocular pressure (IOP) lowering medication for 20 years for ocular hypertension of the right and preperimetric primary open-angle glaucoma of the left eye (with reproducible inferotemporal and superotemporal neuroretinal rim and RNFL loss) was prospectively imaged with the AngioVue OCT for RNFLT, GCC thickness, and PAFD, and investigated with the Octopus Normal G2 visual field test on the same days at 6-month intervals for 18 months, while the IOP of the left eye escaped from control...
May 26, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28553323/phosphatidylserine-improves-axonal-transport-by-inhibition-of-hdac-and-has-potential-in-treatment-of-neurodegenerative-diseases
#15
REVIEW
Shiran Naftelberg, Gil Ast, Eran Perlson
Familial dysautonomia (FD) is a rare children neurodegenerative disease caused due to a point mutation in the IKBKAP gene that results in decreased IKK complex-associated protein (IKAP) protein production. The disease affects mostly the dorsal root ganglion (DRG) and the sympathetic ganglion. Recently, we found that the molecular mechanisms underlying neurodegeneration in FD patients are defects in axonal transport of nerve growth factors and microtubule stability in the DRG. Neurons are highly polarized cells with very long axons...
April 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28542230/visual-field-changes-after-vitrectomy-with-internal-limiting-membrane-peeling-for-epiretinal-membrane-or-macular-hole-in-glaucomatous-eyes
#16
Shunsuke Tsuchiya, Tomomi Higashide, Kazuhisa Sugiyama
PURPOSE: To investigate visual field changes after vitrectomy for macular diseases in glaucomatous eyes. METHODS: A retrospective review of 54 eyes from 54 patients with glaucoma, who underwent vitrectomy for epiretinal membrane (ERM; 42 eyes) or macular hole (MH; 12 eyes). Standard automated perimetry (Humphrey visual field 24-2 program) was performed and analyzed preoperatively and twice postoperatively (1st and 2nd sessions; 4.7 ± 2.5, 10.3 ± 3.7 months after surgery, respectively)...
2017: PloS One
https://www.readbyqxmd.com/read/28539261/g-protein-coupled-receptor-91-signaling-in-diabetic-retinopathy-and-hypoxic-retinal-diseases
#17
Jianyan Hu, Tingting Li, Xinhua Du, Qiang Wu, Yun-Zheng Le
G protein-coupled receptor 91 (GPR91) is a succinate-specific receptor and activation of GPR91 could initiate a complex signal transduction cascade and upregulate inflammatory and pro-angiogenic cytokines. In the retina, GPR91 is predominately expressed in ganglion cells, a major cellular entity involved in the pathogenesis of diabetic retinopathy (DR) and other hypoxic retinal diseases. During the development of DR and retinopathy of prematurity (ROP), chronic hypoxia causes an increase in the levels of local succinate...
May 21, 2017: Vision Research
https://www.readbyqxmd.com/read/28538035/structure-function-analysis-of-nonarteritic-anterior-ischemic-optic-neuropathy-and-age-related-differences-in-outcome
#18
Ming-Hui Sun, Yaping Joyce Liao
BACKGROUND: The optic nerve head is vulnerable to ischemia leading to anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in those older than 50 years of age. METHODS: We performed a cross-sectional study of 55 nonarteritic anterior ischemic optic neuropathy (NAION) eyes in 34 patients to assess clinical outcome and perform structure-function correlations. RESULTS: The peak age of NAION onset was between 50 and 55 years...
May 18, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28536832/proteomic-profiling-reveals-crucial-retinal-protein-alterations-in-the-early-phase-of-an-experimental-glaucoma-model
#19
Fabian Anders, Julia Teister, Sebstian Funke, Norbert Pfeiffer, Franz Grus, Thanos Solon, Verena Prokosch
PURPOSE: Clinical glaucoma is difficult to assess in terms of molecular pathophysiology, prompting studies in experimental models of glaucoma. The purpose of this study was to investigate quantitative changes in retinal protein expression at the onset of experimental glaucoma in rats. Analyzing the proteome provides a suitable tool to decipher the pathophysiological processes in glaucomatous degeneration. METHODS: Thermic cauterization of episcleral veins was utilized to elevate the intraocular pressure in Sprague Dawley rats...
July 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28532352/understanding-glaucomatous-optic-neuropathy-the-synergy-between-clinical-observation-and-investigation
#20
Harry A Quigley
Glaucoma is a complex disorder of aging defined by the death of retinal ganglion cells and remodeling of connective tissues at the optic nerve head. Intraocular pressure-induced axonal injury at the optic nerve head leads to apoptosis. Loss of retinal ganglion cells follows a slowly progressive sequence. Clinical features of the disease have suggested and corroborated pathological events. The death of retinal ganglion cells causes secondary loss of neurons in the brain, but only as a by-product of injury to the retinal ganglion cells...
October 14, 2016: Annual Review of Vision Science
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