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Ganglion cell complex

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https://www.readbyqxmd.com/read/27932951/high-pressure-induced-mtdna-alterations-in-retinal-ganglion-cells-and-subsequent-apoptosis
#1
Sheng-Hai Zhang, Feng-Juan Gao, Zhong-Mou Sun, Ping Xu, Jun-Yi Chen, Xing-Huai Sun, Ji-Hong Wu
Purpose: Our previous study indicated that mitochondrial DNA (mtDNA) damage and mutations are crucial to the progressive loss of retinal ganglion cells (RGCs) in a glaucomatous rat model. In this study, we examined whether high pressure could directly cause mtDNA alterations and whether the latter could lead to mitochondrial dysfunction and RGC death. Methods: Primary cultured rat RGCs were exposed to 30 mm Hg of hydrostatic pressure (HP) for 12, 24, 48, 72, 96 and 120 h. mtDNA alterations and mtDNA repair/replication enzymes OGG1, MYH and polymerase gamma (POLG) expressions were also analyzed...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27930757/association-between-regular-cannabis-use-and-ganglion-cell-dysfunction
#2
Thomas Schwitzer, Raymund Schwan, Eliane Albuisson, Anne Giersch, Laurence Lalanne, Karine Angioi-Duprez, Vincent Laprevote
Importance: Because cannabis use is a major public health concern and cannabis is known to act on central neurotransmission, studying the retinal ganglion cells in individuals who regularly use cannabis is of interest. Objective: To determine whether the regular use of cannabis could alter the function of retinal ganglion cells in humans. Design, Setting, and Participants: For this case-control study, individuals who regularly use cannabis, as well as healthy controls, were recruited, and data were collected from February 11 to October 28, 2014...
December 8, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27928400/optical-coherence-tomography-angiography-in-a-patient-with-optic-atrophy-after-non-arteritic-anterior-ischaemic-optic-neuropathy
#3
Tomoaki Higashiyama, Yusuke Ichiyama, Sanae Muraki, Yasuhiro Nishida, Masahito Ohji
A 75-year-old female noticed a lower visual field (VF) defect in the right eye. A diagnosis of non-arteritic anterior ischaemic optic neuropathy (NAION) was made. The lower VF defect in the right eye did not change after onset. Optical coherence tomography (OCT) angiograms on the disc and the macula showed decreased retinal perfusion in the upper retina of the right eye. Retinal nerve fibre layer loss and ganglion cell complex loss in the upper retina were also seen in the right eye. OCT angiography could non-invasively detect the decrease of the retinal perfusion due to NAION...
June 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27928393/the-optical-coherence-tomographic-profile-of-leber-hereditary-optic-neuropathy
#4
Thomas R Hedges, Marisa Gobuty, Richard A Manfready, Natalie Erlich-Malona, Caitlin Monaco, Carlos E Mendoza-Santiesteban
The objective of this study was to describe the changes in the retinal ganglion cell complex (GCC) relative to the retinal nerve fibre layer (RNFL) over time in Leber hereditary optic neuropathy (LHON) patients. Average RNFL and GCC thickness was measured in seven patients in the early acute (123, 68.4 μm), late acute (113.5, 57.4 μm), and chronic (72.7, 50.8 μm) phases. Patients showed thinning of the GCC with RNFL swelling in the early acute phase. GCC thinning became severe within weeks and persisted...
June 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27917684/the-long-term-effect-of-oral-isotretinoin-therapy-on-macula-ganglion-cell-complex-thickness
#5
Gülizar Demirok, Yasemin Topalak, Özge Gündüz, Dilsun Yıldırım, Mehmet Fatih Kocamaz, Ahmet Sengun
PURPOSE: To evaluate the long term effect of oral isotretinoin therapy on macula ganglion cell complex (GCC) thickness by spectral domain optical coherence tomography (SD-OCT). MATERIALS AND METHODS: Newly diagnosed cystic acne patients who received low dose for a long time systemic isotretinoin therapy were included to study. Thorough ophthalmic evaluation and GCC thickness analysis by using SD-OCT were performed at baseline, and at 1, 3, 6, and 12 months of treatment...
December 4, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27916698/cellular-mechanisms-of-noise-induced-hearing-loss
#6
Arwa Kurabi, Elizabeth M Keithley, Gary D Housley, Allen F Ryan, Ann C-Y Wong
Exposure to intense sound or noise can result in purely temporary threshold shift (TTS), or leave a residual permanent threshold shift (PTS) along with alterations in growth functions of auditory nerve output. Recent research has revealed a number of mechanisms that contribute to noise-induced hearing loss (NIHL). The principle cause of NIHL is damage to cochlear hair cells and associated synaptopathy. Contributions to TTS include reversible damage to hair cell (HC) stereocilia or synapses, while moderate TTS reflects protective purinergic hearing adaptation...
December 1, 2016: Hearing Research
https://www.readbyqxmd.com/read/27911114/changes-of-tangential-traction-after-macular-peeling-correlation-between-en-face-analysis-and-macular-sensitivity
#7
Mario R Romano, Gilda Cennamo, Ida Cesarano, Domenico Cardone, Giuseppe Nicoletti, Rodolfo Mastropasqua, Giovanni Cennamo
PURPOSE: To assess the epi- and intra-retinal morphology changes of the tangential tractions following vitreoretinal surgery for epiretinal membranes and to investigate the correlation between the depth of retinal changes and functional macular sensitivity (MS). METHODS: This is a prospective cross-sectional interventional study, in which 73 eyes of 73 patients with diagnosis of idiopathic epiretinal membrane (iERM) were evaluated. All patients received complete ophthalmic evaluation, including axial and en-face scanning spectral domain-optical coherence tomography (SD-OCT) analysis and microperimetry...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27910945/thyroid-transcription-factor-1-distinguishes-subependymal-giant-cell-astrocytoma-from-its-mimics-and-supports-its-cell-origin-from-the-progenitor-cells-in-the-medial-ganglionic-eminence
#8
Jen-Fan Hang, Chih-Yi Hsu, Shih-Chieh Lin, Chih-Chun Wu, Han-Jui Lee, Donald Ming-Tak Ho
Subependymal giant cell astrocytoma is a benign brain tumor mostly associated with tuberous sclerosis complex. However, it may be misinterpreted as other high-grade brain tumors due to the presence of large tumor cells with conspicuous pleomorphism and occasional atypical features, such as tumor necrosis and endothelial proliferation. In this study, we first investigated thyroid transcription factor-1 (TTF-1) expression in a large series of subependymal giant cell astrocytomas and other histologic and locational mimics to validate the diagnostic utility of this marker...
December 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27903729/joint-encoding-of-object-motion-and-motion-direction-in-the-salamander-retina
#9
Norma Krystyna Kühn, Tim Gollisch
: The processing of motion in visual scenes is important for detecting and tracking moving objects as well as for monitoring self-motion through the induced optic flow. Specialized neural circuits have been identified in the vertebrate retina for detecting motion direction or for distinguishing between object motion and self-motion, although little is known about how information about these distinct features of visual motion is combined. The salamander retina, which is a widely used model system for analyzing retinal function, contains object-motion-sensitive (OMS) ganglion cells, which strongly respond to local motion signals but are suppressed by global image motion...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27900480/deep-and-superficial-oct-angiography-changes-after-macular-peeling-idiopathic-vs-diabetic-epiretinal-membranes
#10
Mario R Romano, Gilda Cennamo, Stefano Schiemer, Claudia Rossi, Federica Sparnelli, Giovanni Cennamo
BACKGROUND: To assess changes in deep and superficial perifoveal capillary plexus after macular peeling in idiopathic and diabetic epiretinal membrane (iERM and dERM, respectively). METHODS: Cross-sectional comparative study. We included 40 eyes from 40 patients affected by iERM (20 eyes) and dERM (20 eyes), as well as 34 eyes from 17 healthy, age-matched patients. Patients received a complete ophthalmic evaluation including axial and en-face scanning spectral-domain analysis, optical coherence tomography angiography, and microperimetry...
November 30, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27898981/macular-features-in-retinitis-pigmentosa-correlations-among-ganglion-cell-complex-thickness-capillary-density-and-macular-function
#11
Lisa Toto, Enrico Borrelli, Rodolfo Mastropasqua, Alfonso Senatore, Luca Di Antonio, Marta Di Nicola, Paolo Carpineto, Leonardo Mastropasqua
Purpose: To investigate correlations among macular ganglion cell complex (GCC) layer thickness, macular capillary density, and macular function in patients affected by retinitis pigmentosa (RP). Methods: Fourteen patients (28 eyes) with previous diagnosis of RP were enrolled. The diagnosis of these conditions was made based on both clinical features and electrophysiological examination. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography (OCTA) and multifocal electroretinogram (mfERG)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27893004/genetic-and-environmental-factors-associated-with-the-ganglion-cell-complex-in-a-healthy-aging-british-cohort
#12
Edward Bloch, Ekaterina Yonova-Doing, Eneh Jones-Odeh, Katie M Williams, Diana Kozareva, Christopher J Hammond
Importance: Measurement of ganglion cell complex (GCC) thickness may be more sensitive than current methods for glaucoma diagnosis and research. However, little is known about the factors influencing GCC thickness in the general population. Objectives: To investigate the heritability of and factors associated with GCC thickness in a healthy aging population. Design, Setting, and Participants: A cross-sectional twin study was conducted from August 27, 2014, to March 31, 2016, among 1657 participants of white British ancestry from the TwinsUK study cohort without ocular pathologic conditions...
November 17, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27890822/visual-light-effects-on-mitochondria-the-potential-implications-in-relation-to-glaucoma
#13
Neville N Osborne, Claudia Núñez-Álvarez, Susana Del Olmo-Aguado, Jesús Merrayo-Lloves
Light of different wave-lengths have the potential to interact with four major mitochondrial protein complexes that are involved in the generation of ATP. Neurones of the central nervous system have an absolute dependence on mitochondrial generated ATP. Laboratory studies show that short-wave or blue light (400-480nm) that impinges on the retina affect flavin and cytochrome constituents associated with mitochondria to decrease the rate of ATP formation, stimulate ROS and results in cell death. This suggests that blue light could potentially have a negative influence on retinal ganglion cell (RGC) mitochondria that are abundant and not shielded by macular pigments as occurs for photoreceptor mitochondria...
November 24, 2016: Mitochondrion
https://www.readbyqxmd.com/read/27874246/predicting-the-intereye-asymmetry-in-functional-and-structural-damage-in-glaucoma-using-automated-pupillography
#14
Harsha L Rao, Sujatha V Kadambi, Srilakshmi Dasari, Hemanth B Reddy, Meena Palakurthy, Mohammed Riyazuddin, Narendra K Puttaiah, Zia S Pradhan, Dhanaraj A S Rao, Rohit Shetty
PURPOSE: To predict the intereye asymmetry in functional (mean deviation, MD on visual field, VF) and structural (retinal nerve fibre layer, RNFL and ganglion cell complex, GCC thickness on spectral domain optical coherence tomography, SDOCT) measurements in glaucoma using the automated pupillography parameters. METHODS: Fifty-nine subjects with a diagnosis of either glaucoma or glaucoma suspect underwent automated pupillography along with VF and SDOCT examinations...
November 22, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27870778/inter-visit-test-retest-variability-of-oct-in-glaucoma
#15
John Graham Pearce, Ted Maddess
PURPOSE: To determine the inter-visit test-retest variability (TRV) of a spectral domain optical coherence tomograph, the Topcon 3D OCT-2000, in the measurement of optic nerve head topography, peripapillary retinal nerve fiber layer (pRNFL), and macular ganglion cell complex (GCC) parameters in glaucoma patients. We also examine whether TRV with this instrument varies with the extent of glaucomatous damage. METHODS: Twenty-four subjects with varying degrees of glaucoma severity provided 41 eyes with usable results for the study...
November 19, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27865948/neuronal-fc-epsilon-receptor-i-contributes-to-antigen-evoked-pruritus-in-a-murine-model-of-ocular-allergy
#16
Fan Liu, Lubin Xu, Naze Chen, Mo Zhou, Chunyan Li, Qian Yang, Yikuan Xie, Yuguang Huang, Chao Ma
Pruritus is the major symptom of ocular allergy but currently available treatments are often ineffective. Previous studies demonstrated that subpopulations of primary sensory neurons express Fc receptors and may contribute to antigen-specific pain. We investigated the role of neuronal Fc-epsilon Receptor I (FcεRI) in allergic ocular pruritus. Ovalbumin (OVA) was used as allergen together with alum adjuvant (OVA+alum) to produce a mouse model of ocular allergy with a significant elevation in the serum levels of both antigen-specific IgE and IgG...
November 16, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27865693/-point-by-point-approach-to-structure-function-correlation-of-glaucoma-on-the-ganglion-cell-complex-in-the-posterior-pole
#17
M Zeitoun
PURPOSE: To try to establish a "point by point" relationship between the local thickness of the retinal ganglion cell complex and its sensitivity. MATERIALS AND METHODS: In total, 104 glaucomatous eyes of 89 patients with a confirmed 24-2 visual field, were measured by superimposing the visual field, using imaging software, with the Wide 40° by 30° measurements of retinal ganglion cell complex obtained from the Topcon(©) 3D 2000 OCT, after upward adjustment, inversion and scaling...
November 17, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27859858/diffusion-weighted-imaging-helps-differentiate-multiple-sclerosis-and-neuromyelitis-optica-related-acute-optic-neuritis
#18
Hailin Wan, Huijin He, Fang Zhang, Yan Sha, Guohong Tian
PURPOSE: To evaluate the apparent diffusion coefficient (ADC) values between multiple sclerosis (MS) and neuromyelitis optica (NMO)-related acute optic neuritis (ON) patients and predict their optic nerve atrophy of optic coherence tomography (OCT) parameters. MATERIALS AND METHODS: Nineteen MS and 15 NMO-related acute ON patients who underwent a diffusion-weighted imaging sequence in 3.0 Tesla MR scanner and a follow-up OCT examination after 6 months were included...
November 9, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27857681/early-cytoskeletal-protein-modifications-precede-overt-structural-degeneration-in-the-dba-2j-mouse-model-of-glaucoma
#19
Gina N Wilson, Matthew A Smith, Denise M Inman, Christine M Dengler-Crish, Samuel D Crish
Axonal transport deficits precede structural loss in glaucoma and other neurodegenerations. Impairments in structural support, including modified cytoskeletal proteins, and microtubule-destabilizing elements, could be initiating factors in glaucoma pathogenesis. We investigated the time course of changes in protein levels and post-translational modifications in the DBA/2J mouse model of glaucoma. Using anterograde tract tracing of the retinal projection, we assessed major cytoskeletal and transported elements as a function of transport integrity in different stages of pathological progression...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27843286/effect-of-cataract-surgery-on-subfoveal-choroidal-and-ganglion-cell-complex-thicknesses-measured-by-enhanced-depth-imaging-optical-coherence-tomography
#20
Erkan Celik, Burcin Cakır, Elif Betul Turkoglu, Emine Doğan, Gursoy Alagoz
PURPOSE: We aimed to evaluate the effect of cataract surgery on subfoveal choroidal thickness (CT) and ganglion cell complex (GCC) thickness, as measured by enhanced depth imaging-optical coherence tomography (OCT). METHODS: This prospective study included 30 eyes of 30 patients who had undergone uneventful phacoemulsification surgery for senile cataract but had no previous ocular surgery or other ocular abnormality. Best-corrected visual acuity, slit-lamp biomicroscopy, intraocular pressure, axial length, and central corneal thickness were measured preoperatively...
2016: Clinical Ophthalmology
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