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Ganglion cell complex

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https://www.readbyqxmd.com/read/28330877/k-channel-modulatory-subunits-kchip-and-dpp-participate-in-kv4-mediated-mechanical-pain-control
#1
Yen-Ling Kuo, Jen-Kun Cheng, Wen-Hsien Hou, Yu-Cheng Chang, Po-Hao Du, Jhao-Jun Jian, Ruey-Horng Rau, Jung-Hui Yang, Cheng-Chang Lien, Meei-Ling Tsaur
The K(+) channel pore-forming subunit Kv4.3 is expressed in a subset of non-peptidergic nociceptors within the dorsal root ganglion (DRG), and knockdown of Kv4.3 selectively induces mechanical hypersensitivity, a major symptom of neuropathic pain. K(+) channel modulatory subunits KChIP1, KChIP2 and DPP10 are coexpressed in Kv4.3(+) DRG neurons, but whether they participate in Kv4.3-mediated pain control is unknown. Here, we show the existence of a Kv4.3/KChIP1/KChIP2/DPP10 complex (abbreviated as the Kv4 complex) in the endoplasmic reticulum and cell surface of DRG neurons...
March 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28323869/tyrosine-mutated-aav2-mediated-shrna-silencing-of-pten-promotes-axon-regeneration-of-adult-optic-nerve
#2
ZhengRu Huang, ZiZhong Hu, Ping Xie, QingHuai Liu
Activating PI3K/AKT/mTOR signaling pathway via deleting phosphatase and tensin homolog (PTEN) has been confirmed to enhance intrinsic growth capacity of neurons to facilitate the axons regeneration of central nervous system after injury. Considering conditional gene deletion is currently not available in clinical practice, we exploited capsid residue tyrosine 444 to phenylalanine mutated single-stranded adeno-associated virus serotype 2 (AAV2) as a vector delivering short hairpin RNA to silence PTEN to promote retinal ganglion cells (RGCs) survival and axons regeneration in adult rat optic nerve axotomy paradigm...
2017: PloS One
https://www.readbyqxmd.com/read/28319450/retinal-and-choroidal-thickness-in-adult-patients-with-familial-mediterranean-fever
#3
Tolga Bicer, Osman Celikay, Mustafa Kosker, Muhammed Yunus Alp, Cem Ozisler, Ahmet Yesilyurt, Burcu Kucuk Bicer, Canan Gurdal
PURPOSE: We aimed to evaluate changes in retinal, choroidal, ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) thicknesses in genetically diagnosed adult patients with familial Mediterranean fever (FMF). METHODS: A total of 50 eyes of 50 genetically diagnosed patients with FMF and 50 eyes of controls were analyzed. Patients were recruited from the Genetic Diagnostic Center of Dışkapı Yıldırım Beyazıt Research and Training Hospital, Turkey. Retinal and choroidal thicknesses were obtained using spectral-domain optical coherence tomography from choroid, retina, GCC, and RNFL...
March 20, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28301863/optical-coherence-tomography-angiography-in-nonarteritic-anterior-ischemic-optic-neuropathy
#4
Emily Wright Mayes, Emily D Cole, Sabin Dang, Eduardo A Novais, Laurel Vuong, Carlos Mendoza-Santiesteban, Jay S Duker, Thomas R Hedges
BACKGROUND: Optical coherence tomography angiography (OCTA) has demonstrated good utility in qualitative analysis of retinal and choroidal vasculature and therefore may be relevant in the diagnostic and treatment efforts surrounding nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: Retrospective, cross-sectional study of 10 eyes of 9 patients with a previous or new diagnosis of NAION that received imaging with OCTA between November 2015 and February 2016...
March 15, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28300739/circumpapillary-ganglion-cell-complex-thickness-to-diagnose-glaucoma-a-pilot-study
#5
Yoshiyuki Kita, Norihisa Soutome, Daisuke Horie, Ritsuko Kita, Gaborá Hollό
PURPOSE: The purpose of this study is to evaluate the applicability of a new optical coherence tomography parameter, the circumpapillary ganglion cell complex (cpGCC) thickness for glaucoma diagnostics. SUBJECTS AND METHODS: The RS-3000 Advance SD-OCT (NIDEK, Aichi, Japan) was used to measure global and sector macular GCC (mGCC) thickness, circumpapillary retinal nerve fiber layer (cpRNFL) thickness, cpGCC, and circumpapillary total retina (cpTR) thickness in 1 eye of 48 preperimetric/early perimetric primary open-angle glaucoma patients and 28 healthy Japanese participants...
January 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28288185/a-comparison-of-the-diagnostic-ability-of-vessel-density-and-structural-measurements-of-optical-coherence-tomography-in-primary-open-angle-glaucoma
#6
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Mohammed Riyazuddin, Srilakshmi Dasari, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To compare the diagnostic abilities of vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary open angle glaucoma (POAG) with that of the ONH rim area, peripapillary retinal nerve fiber layer (RNFL) thickness and the macular ganglion cell complex (GCC) thickness measurements. METHODS: In a cross sectional study, 78 eyes of 50 control subjects and 117 eyes of 67 POAG patients underwent vessel density and structural measurements with spectral domain OCT...
2017: PloS One
https://www.readbyqxmd.com/read/28284341/mog-antibody-associated-demyelinating-disease-of-the-cns-a-clinical-and-pathological-study-in-chinese-han-patients
#7
Lei Zhou, Yongheng Huang, Haiqing Li, Jie Fan, Jingzi Zhangbao, Hai Yu, Yuxin Li, Jiahong Lu, Chongbo Zhao, Chuanzhen Lu, Min Wang, Chao Quan
We aim to evaluate the clinical relevance of MOG-ab in a cohort of Chinese Han adults with CNS inflammatory demyelinating diseases (IDDs). MOG-ab and AQP4-ab were examined through a fixed cell based indirect immune-fluorescence assay in 86 patients with CNS-IDDs. MOG-ab was positive in 12 patients, while AQP4-ab was positive in 31 patients; none double positives. Optic neuritis (ON) was the most frequent symptom at onset (75.0%) or during the whole disease course (83.3%) of MOG-ab associated IDDs (MOG-IDDs); 79...
April 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28282698/-oct-angiography-of-the-glaucoma-optic-nerve
#8
C Lommatzsch, J M Koch, H Claußnitzer, C Heinz
Background Glaucoma is a major cause of blindness worldwide. One possible pathophysiological cause may be vascular dysregulation. Our aim was to investigate whether OCT angiography (OCTA) can detect modified flow density in glaucoma patients in the area of the optic disc. Methods A total of 68 eyes were examined by the OCTA system AngioVue™, including 34 eyes diagnosed with glaucoma and 34 healthy control eyes. Total peripapillary flow density was measured at two different levels of segmentation and also in each optic disc sector...
March 10, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28275163/axonal-degeneration-in-retinal-ganglion-cells-is-associated-with-a-membrane-polarity-sensitive-redox-process
#9
Mohammadali Almasieh, Maria-Magdalena Catrinescu, Loïc Binan, Santiago Costantino, Leonard A Levin
Axonal degeneration is a pathophysiological mechanism common to several neurodegenerative diseases. The slow Wallerian degeneration (Wld(S)) mutation, which results in reduced axonal degeneration in the central and peripheral nervous systems, has provided insight for a redox-dependent mechanism by which axons undergo self-destruction. We studied early molecular events in axonal degeneration with single-axon laser axotomy and time-lapse imaging, monitoring the initial changes in transected axons of purified retinal ganglion cells (RGCs) from wild-type and Wld(S) rat retinas using a polarity-sensitive annexin-based biosensor (annexin B12-Cys101,Cys260-N,N'-dimethyl-N-(iodoacetyl)-N'-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) ethylenediamine)...
March 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28263785/nociceptive-neuronal-fc-gamma-receptor-i-is-involved-in-igg-immune-complex-induced-pain-in-the-rat
#10
Haowu Jiang, Xinhua Shen, Zhiyong Chen, Fan Liu, Tao Wang, Yikuan Xie, Chao Ma
Antigen-specific immune diseases such as rheumatoid arthritis are often accompanied by pain and hyperalgesia. Our previous studies have demonstrated that Fc-gamma-receptor type I (FcγRI) is expressed in a subpopulation of rat dorsal root ganglion (DRG) neurons and can be directly activated by IgG immune complex (IgG-IC). In this study we investigated whether neuronal FcγRI contributes to antigen-specific pain in the naïve and rheumatoid arthritis model rats. In vitro calcium imaging and whole-cell patch clamp recordings in dissociated DRG neurons revealed that only the small-, but not medium- or large-sized DRG neurons responded to IgG-IC...
March 2, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28254884/a-functional-coupling-between-crmp1-and-nav1-7-for-retrograde-propagation-of-semaphorin3a-signaling
#11
Masayuki Yamane, Naoya Yamashita, Tomonobu Hida, Yoshinori Kamiya, Fumio Nakamura, Pappachan Kolattukudy, Yoshio Goshima
Semaphorin3A (Sema3A) is a secreted type of axon guidance molecules that regulates axon wiring through neuropilin-1 (NRP1) and PlexinAs (PlexAs) receptor complex. Sema3A regulates the dendritic branching through a tetrodotoxin (TTX)-sensitive retrograde axonal transport of PlexAs and Tropomyosin-related kinase A (TrkA) complex. We here demonstrate that Nav1.7, a TTX-sensitive Na(+) channel, by coupling with collapsin response mediator protein 1 (CRMP1), mediates the Sema3A-induced retrograde transport. In mouse dorsal root ganglion (DRG) neurons, Sema3A increased co-localization of PlexA4 and TrkA in the growth cones and axons...
March 2, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28254626/vessel-density-and-structural-measurements-of-optical-coherence-tomography-in-primary-angle-closure-and-primary-angle-closure-glaucoma
#12
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Mohammed Riyazuddin, Srilakshmi Dasari, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll Ab Webers
PURPOSE: To evaluate the vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary angle closure (PAC) and primary angle closure glaucoma (PACG), and to compare their diagnostic abilities with the ONH rim area, peripapillary retinal nerve fiber layer (RNFL) thickness and the macular ganglion cell complex (GCC) thickness measurements on OCT in PACG. DESIGN: Cross-sectional study METHODS: Seventy-seven eyes of 50 control subjects, 65 eyes of 45 patients with PACG, and 31 eyes of 22 PAC patients with a history of high IOP, underwent imaging with OCT...
February 27, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28252388/three-dimensional-segmentation-of-the-ex-vivo-anterior-lamina-cribrosa-from-second-harmonic-imaging-microscopy
#13
Sundaresh Ram, Forest Danford, Stephen Howerton, Jeffrey Rodriguez, Jonathan Vande Geest
The lamina cribrosa (LC) 1 is a connective tissue in the posterior eye with a complex mesh-like trabecular microstructure through which all the retinal ganglion cell axons and central retinal vessels pass. Recent studies have demonstrated that changes in the structure of the LC correlate with glaucomatous damage. Thus, accurate segmentation and reconstruction of the LC is of utmost importance. This paper presents a new automated method for segmenting the microstructure of the anterior LC in the images obtained via multiphoton microscopy using a combination of ideas...
February 23, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28245283/ganglionated-plexi-stimulation-induces-pulmonary-vein-triggers-and-promotes-atrial-arrhythmogenecity-in-silico-modeling-study
#14
Minki Hwang, Byounghyun Lim, Jun-Seop Song, Hee Tae Yu, Ah-Jin Ryu, Young-Seon Lee, Boyoung Joung, Eun Bo Shim, Hui-Nam Pak
BACKGROUND: The role of the autonomic nervous system (ANS) on atrial fibrillation (AF) is difficult to demonstrate in the intact human left atrium (LA) due to technical limitations of the current electrophysiological mapping technique. We examined the effects of the ANS on the initiation and maintenance of AF by employing a realistic in silico human left atrium (LA) model integrated with a model of ganglionated plexi (GPs). METHODS: We incorporated the morphology of the GP and parasympathetic nerves in a three-dimensional (3D) realistic LA model...
2017: PloS One
https://www.readbyqxmd.com/read/28223208/characterizing-the-poagome-a-bioinformatics-driven-approach-to-primary-open-angle-glaucoma
#15
REVIEW
Ian D Danford, Lana D Verkuil, Daniel J Choi, David W Collins, Harini V Gudiseva, Katherine E Uyhazi, Marisa K Lau, Levi N Kanu, Gregory R Grant, Venkata R M Chavali, Joan M O'Brien
Primary open-angle glaucoma (POAG) is a genetically, physiologically, and phenotypically complex neurodegenerative disorder. This study addressed the expanding collection of genes associated with POAG, referred to as the "POAGome." We used bioinformatics tools to perform an extensive, systematic literature search and compiled 522 genes with confirmed associations with POAG and its related phenotypes (normal tension glaucoma, ocular hypertension, juvenile open-angle glaucoma, and primary congenital glaucoma)...
February 18, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28223180/biomechanical-aspects-of-axonal-damage-in-glaucoma-a-brief-review
#16
REVIEW
Cheri Stowell, Claude Burgoyne, Ernst R Tamm, C Ross Ethier
The biomechanical environment within the optic nerve head (ONH) is complex and is likely directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our understanding of this process is poor. Here we describe factors that influence ONH biomechanics, including ONH connective tissue microarchitecture and anatomy; intraocular pressure (IOP); and cerebrospinal fluid pressure (CSFp). We note that connective tissue factors can vary significantly from one individual to the next, as well as regionally within an eye, and that the understanding of ONH biomechanics is hindered by anatomical differences between small-animal models of glaucoma (rats and mice) and humans...
February 18, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28218219/reduced-macular-vascular-density-in-myopic-eyes
#17
Hua Fan, Hao-Yu Chen, Hong-Jie Ma, Zheng Chang, Hai-Quan Yin, Danny Siu-Chun Ng, Carol Y Cheung, Shan Hu, Xiang Xiang, Shi-Bo Tang, Shuang-Nong Li
BACKGROUND: Morphological changes of the vasculature system in patients with myopia have been observed by Doppler ultrasound and fundus fluorescein angiography (FFA); however, these studies have limitations. Doppler ultrasound provides low-resolution images which are mainly obtained from visualized large vessels, and FFA is an invasive examination. Optic coherence tomography (OCT) angiography is a noninvasive, high-resolution measurement for vascular density. The purpose of this study was to investigate the change of vascular density in myopic eyes using OCT angiography...
February 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28209965/high-amplitude-electrical-stimulation-can-reduce-elicited-neuronal-activity-in-visual-prosthesis
#18
Alejandro Barriga-Rivera, Tianruo Guo, Chih-Yu Yang, Amr Al Abed, Socrates Dokos, Nigel H Lovell, John W Morley, Gregg J Suaning
Retinal electrostimulation is promising a successful therapy to restore functional vision. However, a narrow stimulating current range exists between retinal neuron excitation and inhibition which may lead to misperformance of visual prostheses. As the conveyance of representation of complex visual scenes may require neighbouring electrodes to be activated simultaneously, electric field summation may contribute to reach this inhibitory threshold. This study used three approaches to assess the implications of relatively high stimulating conditions in visual prostheses: (1) in vivo, using a suprachoroidal prosthesis implanted in a feline model, (2) in vitro through electrostimulation of murine retinal preparations, and (3) in silico by computing the response of a population of retinal ganglion cells...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205530/retinal-structure-and-function-in-eyes-with-optic-nerve-hypoplasia
#19
Satoshi Katagiri, Sachiko Nishina, Tadashi Yokoi, Masashi Mikami, Yuri Nakayama, Michiko Tanaka, Noriyuki Azuma
We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were performed. SD-OCT analysis of the macular region showed significant ganglion cells complex (GCC) thinning nasally and temporally (P < 0.05), but the thickness from the inner nuclear layer (INL) to the retinal pigment epithelium (RPE) became thinner only nasally (P < 0...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28199381/impact-of-the-anti-aquaporin-4-autoantibody-on-inner-retinal-structure-function-and-structure-function-associations-in-japanese-patients-with-optic-neuritis
#20
Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Ichiro Nakashima, Makoto Nakamura
PURPOSE: An autoantibody against aquaporin-4 (AQP4 Ab) is highly specific for neuromyelitis optica spectrum disorder and plays a pathogenic role in this disease. The purpose of this study was to investigate the impact of AQP4 Ab on inner retinal structure, function, and the structure-function relationships in eyes with optic neuritis. METHODS: Thirty five eyes from 25 cases who had received visual function tests and RTVue optical coherence tomography (OCT) measurement at least six months after the latest episode of optic neuritis were enrolled...
2017: PloS One
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