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Choroidal thickness

K X Cheong, L W Lim, K Z Li, C S Tan
PurposeChoroidal thickness (CT) measurements are typically obtained from manual segmentation of optical coherence tomography (OCT) B-scans. This method is time-consuming. We aimed to describe a novel and faster technique to obtain CT measurements.Patients and methodsIn a prospective cohort study of 200 healthy eyes, Spectral-Domain OCT with enhanced depth imaging were performed with the Spectralis OCT using standardised imaging protocols. The OCT scans were independently graded by reading centre-certified graders...
October 20, 2017: Eye
Yu-Tien Chi, Chang-Hao Yang, Cheng-Kuo Cheng
Importance: Investigating the quantitative 3-dimensional (3-D) anatomy of polypoidal complex is important for a better understanding of the pathogenesis of polypoidal choroidal vasculopathy (PCV). Objective: To quantitatively evaluate the 3-D characteristics of polypoidal structures, branching vascular networks (BVNs), and origin of PCV using optical coherence tomography angiography (OCTA) and multiple image systems. Design, Setting, and Participants: A prospective, observational study was conducted in 47 consecutive Taiwanese patients (47 eyes) from May 21, 2015, to April 30, 2017...
October 19, 2017: JAMA Ophthalmology
Huizhong Jiang, Zhen Li, Ran Sun, Dachuan Liu, Ningpu Liu
PURPOSE: To assess changes in the thickness of the subfoveal retina and choroid after phacoemulsification using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS: A prospective study was conducted on 100 patients. The subfoveal choroidal thickness (SFCT) was measured at 7 points and the retinal thickness was measured at 5 points (before surgery, and 1 day, 1 week, 1 month, and 3 months after surgery). RESULTS: The foveal choroidal thickness showed a thickening trend (but p > 0...
October 19, 2017: Ophthalmic Research
Sophia S Wong, Vivian S Vuong, David Cunefare, Sina Farsiu, Ala Moshiri, Glenn Yiu
PURPOSE: To determine if different types of retinal fluid in the central macula affect the reproducibility of choroidal thickness (CT) measurements on enhanced depth imaging optical coherence tomography (EDI-OCT) DESIGN: retrospective, reliability analysis METHODS: EDI-OCT images were obtained and the choroidal-scleral junction was analyzed through semi-automated segmentation. CT was measured at the fovea and averaged across the central 3 mm horizontal segment. Demographic data, central macular thickness and type of fluid present were recorded...
October 13, 2017: American Journal of Ophthalmology
Zhongjing Lin, Shouyue Huang, Ping Huang, Lei Guo, Hongjun Bian, Yisheng Zhong
This study aimed to compare choroidal thickness between subjects with ocular hypertension (OHT) and normal individuals and explore factors affecting choroidal thickness. This study included 60 untreated newly diagnosed OHT eyes and 60 normal eyes. Choroidal thickness obtained from Cirrus HD-OCT was measured at different locations in the macular and peripapillary regions and compared between the two groups before and after adjusting for potential confounding variables. Regression analysis was performed to figure out factors influencing choroidal thickness...
October 13, 2017: Lasers in Medical Science
Takehiro Yamashita, Taiji Sakamoto, Naoya Yoshihara, Hiroto Terasaki, Minoru Tanaka, Yuya Kii, Kumiko Nakao
Optical coherence tomography (OCT) has made it possible for clinicians to measure the peripapillary choroidal thickness (ppCT) noninvasively in various ocular diseases. However, the ocular factors associated with the ppCT have not been conclusively determined. The purpose of this study was to determine the relationship between the local ppCT and the axial length, optic disc tilt, and the angle of the papillo-macular position (PMP) in healthy eyes. This was a prospective, observational cross-sectional study of 119 right eyes of 119 healthy Japanese volunteers...
2017: PloS One
Luis Emilio Pablo, Maria Pilar Bambo, Beatriz Cameo, Blanca Ferrández, Noemí Güerri, Vicente Polo, Jose Manuel Larrosa, Javier Moreno-Montañés, Elena Garcia-Martin
PURPOSE: To evaluate automatic peripapillary choroidal thickness (PPCT) measurements in a wide area around the optic disc and various established zones in primary open-angle glaucoma (POAG) patients and age- and sex-matched healthy controls using a new swept-source optical coherence tomography (SS-OCT) device. STUDY DESIGN: Single center cross-sectional observational study. METHODS: A total of 135 POAG patients and 86 healthy subjects were consecutively enrolled...
October 11, 2017: Japanese Journal of Ophthalmology
Aniruddha Agarwal, Rupesh Agrawal, Neha Khandelwal, Alessandro Invernizzi, Kanika Aggarwal, Aman Sharma, Ramandeep Singh, Reema Bansal, Kusum Sharma, Nirbhai Singh, Vishali Gupta
PURPOSE: To assess choroidal vascular changes among patients with tubercular multifocal serpiginoid choroiditis (TB MSC) using previously validated techniques. METHODS: Patients with TB MSC (n = 18) and healthy controls (n = 30) underwent enhanced-depth imaging optical coherence tomography (EDI-OCT) imaging. Using previously validated algorithm of image binarization, EDI-OCT scans were segmented to derive total choroidal area, luminal area, stromal area, and choroidal vascularity index (CVI)...
October 11, 2017: Ocular Immunology and Inflammation
Junichi Takahashi, Masanori Kado, Keiko Mizumoto, Sho Igarashi, Tsunemaro Kojo
BACKGROUND AND OBJECTIVE: This study was performed to investigate longitudinal changes in the subfoveal choroidal thickness (SFCT) during pregnancy and after delivery. PATIENTS AND METHODS: The SFCT was measured in the first and third trimesters, shortly after delivery, and 1 month after delivery in 25 eyes of 25 women. Enhanced depth imaging optical coherence tomography was used for measurement. RESULTS: The mean SFCT was 347 μm ± 86 μm, 329 μm ± 81 μm, 333 μm ± 81 μm, and 330 μm ± 87 μm in the first and third trimesters, shortly after delivery, and 1 month after delivery, respectively...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
Dhanashree Ratra, Roy Tan, Durgasri Jaishankar, Neha Khandelwal, Arushi Gupta, Jay Chhablani, Rupesh Agrawal
PURPOSE: To evaluate structural changes in the choroid of patients with Stargardt disease using swept source optical coherence tomography scans. METHODS: A retrospective comparison cohort study was conducted on 39 patients with Stargardt disease, and on 25 age and gender matched-healthy controls. Subfoveal choroidal thickness (SFCT) was computed from the swept source optical coherence tomography machine, and the scans were binarized into luminal area and stromal areas, which were then used to derive choroidal vascularity index (CVI)...
October 6, 2017: Retina
Riccardo Sacconi, Eleonora Corbelli, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To analyze choriocapillaris (CC) vessel density (VD) around geographic atrophy (GA) secondary to non-neovascular dry age-related macular degeneration using optical coherence tomography angiography. METHODS: We compared CC VD surrounding GA margin (500 μm radius) with control CC (outside GA margin) in a consecutive series of GA patients presenting between August 2016 and February 2017 at the Medical Retina and Imaging Unit of University Vita-Salute, IRCCS Ospedale San Raffaele in Milan...
October 6, 2017: Retina
Alexandre Matet, Suzanne Yzer, Emily Y Chew, Alejandra Daruich, Francine Behar-Cohen, Richard F Spaide
PURPOSE: To describe cases presenting with features of idiopathic macular telangiectasia (MacTel) Type 2 and central serous chorioretinopathy (CSC). METHODS: Databases from four tertiary retina centers were searched for cases copresenting CSC and MacTel Type 2. RESULTS: Five cases were identified (4 men, 1 woman; mean age: 67.2 years). Four patients were referred for chronic or nonresolving CSC, and the diagnosis of MacTel Type 2 was made based on multimodal imaging findings...
October 9, 2017: Retina
Kyou Ho Lee, Seo Hee Kim, Ji Min Lee, Eui Chun Kang, Hyoung Jun Koh
PURPOSE: To investigate the peripapillary choroidal thickness (PCT) of polypoidal choroidal vasculopathy (PCV) and exudative age-related macular degeneration (AMD) and to evaluate their responses to anti-vascular endothelial growth factor (VEGF). METHODS: Thirty eyes with PCV and 25 eyes with exudative AMD who were treatment naïve were included in this study. PCT and subfoveal choroidal thickness were evaluated both before and after intravitreal anti-VEGF. RESULTS: The initial mean PCT of PCV (153...
October 2017: Korean Journal of Ophthalmology: KJO
Jay C Wang, Inês Laíns, Joana Providência, Grayson W Armstrong, Ana R Santos, Pedro Gil, João Gil, Katherine E Talcott, João H Marques, João Figueira, Demetrios G Vavvas, Ivana K Kim, Joan W Miller, Deeba Husain, Rufino Silva, John B Miller
PURPOSE: To compare choroidal vascular density (CVD) and volume (CVV) in diabetic eyes and controls, using en face swept-source optical coherence tomography (SS-OCT). DESIGN: Prospective cross-sectional study. METHODS: ▪▪▪ SETTING: Multicenter PATIENT POPULATION: 143 diabetic eyes - 27 with no diabetic retinopathy (DR), 47 with nonproliferative DR (NPDR), 51 with NPDR and diabetic macular edema (DME), and 18 with proliferative DR (PDR), and 64 age-matched non-diabetic control eyes...
October 5, 2017: American Journal of Ophthalmology
Yufeng N Chen, Robert G Devenyi, Michael H Brent, Peter J Kertes, Kenneth T Eng, Carol E Schwartz, Radha P Kohly, David R Chow, David T Wong, Alan R Berger, Fil Altomare, Louis R Giavedoni, Rajeev H Muni, Alexander Soon, Patrick Yoo, Wai-Ching Lam
OBJECTIVE: To assess how polypoidal choroidal vasculopathy (PCV) is recognized and treated, and to assess whether treatment outcomes are different between Chinese and Caucasian Canadian patients with age-related macular degeneration (AMD). DESIGN: Retrospective chart review. PARTICIPANTS: 154 eyes from 135 Chinese patients and 2291 eyes from 1792 Caucasian patients who were newly diagnosed with either AMD or PCV and had more than 1 year of follow-up were included...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Adrian Koh, Timothy Y Y Lai, Kanji Takahashi, Tien Y Wong, Lee-Jen Chen, Paisan Ruamviboonsuk, Colin S Tan, Chrystel Feller, Philippe Margaron, Tock H Lim, Won Ki Lee
Importance: Polypoidal choroidal vasculopathy (PCV) is a common subtype of exudative age-related macular degeneration among Asian individuals. To our knowledge, there are no large randomized clinical trials to evaluate intravitreal ranibizumab, with and without verteporfin photodynamic therapy (vPDT), for the treatment of PCV. Objective: To compare the efficacy and safety of combination therapy of ranibizumab and vPDT with ranibizumab monotherapy in PCV. Design, Setting, and Participants: A double-masked, multicenter randomized clinical trial of 322 Asian participants with symptomatic macular PCV confirmed by the Central Reading Center using indocyanine green angiography was conducted between August 7, 2013, and March 2, 2017...
October 5, 2017: JAMA Ophthalmology
Tianwei Qian, Xinxin Li, Mengya Zhao, Xun Xu
BACKGROUND: Combined treatment with intravitreal anti-vascular endothelial growth factor (anti-VEGF) and verteporfin photodynamic therapy (PDT) is widely used for patients with polypoidal choroidal vasculopathy (PCV), although clinical evidence regarding the therapeutic efficacy and safety of such treatment remains lacking. DESIGN/METHODS: We performed a meta-analysis of previously reported studies comparing combination treatment, PDT monotherapy, and anti-VEGF monotherapy...
October 5, 2017: European Journal of Clinical Investigation
Tomohiko Akahori, Takeshi Iwase, Kentaro Yamamoto, Eimei Ra, Hiroko Terasaki
Purpose: The purpose of this study was to determine the effects of an elevation in IOP on the choroidal blood flow and morphology. Methods: We studied 27 healthy subjects. The mean blur rate (MBR) determined by laser speckle flowgraphy was used to measure the choroidal blood flow. The subfoveal choroidal thickness (SFCT) was measured in the optical coherence tomographic images of the macular region. The luminal and stromal areas of the choroid were determined by the binarization method before, during, and after the IOP was elevated 20 and 30 mm Hg with pressure using an ophthalmodynamometer...
October 1, 2017: Investigative Ophthalmology & Visual Science
Maximilian Gabriel, Robert Kruger, Farnusch Shams-Mafi, Boris Hermann, Behrooz Zabihian, Leopold Schmetterer, Wolfgang Drexler, Susanne Binder, Marieh Esmaeelpour
Purpose: To analyze retinal thickness (RT) and choroidal thickness (ChT) changes in patients with unilateral nongranulomatous acute anterior uveitis (AAU) using three-dimensional (3D) 1060-nm optical coherence tomography (OCT). Methods: Retinal and choroidal thickness maps were statistically analyzed for 24 patients with newly diagnosed unilateral AAU before therapy. A total of 17 patients were followed until resolution of inflammatory activity (twice in the first week, then weekly)...
September 1, 2017: Investigative Ophthalmology & Visual Science
Maurizio Cammalleri, Massimo Dal Monte, Filippo Locri, Emma Lardner, Anders Kvanta, Dario Rusciano, Helder André, Paola Bagnoli
Current knowledge of the benefits of nutrition supplements for eye pathologies is based largely on the use of appropriate animal models, together with defined dietary supplementation. Here, C57BL6 mice were subretinally injected with polyethylene glycol (PEG)-400, an established model of retinal degeneration with a dry age-related macular degeneration (AMD)-like phenotype, an eye pathology that lacks treatment. In response to PEG-400, markers of the complement system, angiogenesis, inflammation, gliosis, and macrophage infiltration were upregulated in both retinas and retinal pigment epithelium (RPE)/choroids, whereas dietary supplementation with a mixture based on fatty acids counteracted their upregulation...
September 29, 2017: Nutrients
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