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Choroidal thickness

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https://www.readbyqxmd.com/read/29237169/outer-retina-and-choroidal-thickness-in-intermediate-age-related-macular-degeneration-reticular-pseudodrusen-findings
#1
Pedro Camacho, Marco Dutra-Medeiros, Diogo Cabral, Rufino Silva
PURPOSE: To evaluate outer retina and choroidal thickness in subjects with intermediate age-related macular degeneration (iAMD) and to describe associations with the presence of reticular pseudodrusen (RPD). METHODS: This was a retrospective, cross-sectional analysis of 157 consecutive eyes (specifically: 62 eyes classified as having RPD and 95 eyes with drusen ≥125 µm). Only cases with digital color fundus photographs, red-free, and infrared, obtained and graded according to the Age-Related Eye Disease Study to define iAMD, were used for this study...
December 14, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29236748/the-diagnostic-use-of-choroidal-thickness-analysis-and-its-correlation-with-visual-field-indices-in-glaucoma-using-spectral-domain-optical-coherence-tomography
#2
Zhongjing Lin, Shouyue Huang, Ping Huang, Lei Guo, Xi Shen, Yisheng Zhong
PURPOSE: To evaluate the quantitative characteristics of choroidal thickness in primary open-angle glaucoma (POAG), normal tension glaucoma (NTG) and in normal eyes using spectral-domain optical coherence tomography (SD-OCT). To evaluate the diagnostic ability of choroidal thickness in glaucoma and to determine the correlation between choroidal thickness and visual field parameters in glaucoma. METHODS: A total of 116 subjects including 40 POAG, 30 NTG and 46 healthy subjects were enrolled in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29236343/relationship-between-reticular-pseudodrusen-and-choroidal-thickness-in-intermediate-age-related-macular-degeneration
#3
Chi Yun Doreen Ho, Jia Jia Lek, Khin Zaw Aung, Myra B McGuinness, Chi D Luu, Robyn H Guymer
IMPORTANCE: Reticular pseudodrusen (RPD) is strongly associated with late age-related macular degeneration (AMD) but their etiology remains unknown. RPD have been associated with reduced choroidal thickness but most studies are limited by small sample size and varying severity of AMD. BACKGROUND: To investigate the relationship between choroidal thickness (ChT) and RPD in eyes with intermediate AMD (iAMD), controlling for variables known to influence ChT. DESIGN: Retrospective cohort study PARTICIPANTS: Participants were recruited from Centre for Eye Research Australia...
December 13, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29217514/novel-ocular-toxicity-associated-with-fibroblast-growth-factor-receptor-fgfr-inhibitors-in-cancer-treatment-observational-case-series
#4
Daniel Velazquez-Villoria, Analia Azaro, Jordi Rodon, Cinta Hierro, Danai Kyriakou, Jose Garcia-Arumi, Miguel Angel Zapata
AIMS: To describe novel ocular toxicity in patients with metastatic cancer undergoing chemotherapy with fibroblast growth factor receptor (FGFR) inhibitors. METHODS: This observational case series study included five patients with advanced cancer who received selected pan-FGFR inhibitors as single chemotherapy in the framework of a dose-finding study and phase I and phase II clinical studies. In all cases, subfoveal neurosensory retinal detachment was diagnosed...
December 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29212537/association-of-arms2-genotype-with-response-to-anti-vascular-endothelial-growth-factor-treatment-in-polypoidal-choroidal-vasculopathy
#5
Un Chul Park, Joo Young Shin, Hum Chung, Hyeong Gon Yu
BACKGROUND: To investigate whether genetic risk variants for age-related macular degeneration (AMD) are associated with response to intravitreal anti-vascular endothelial growth factor (VEGF) in polypoidal choroidal vasculopathy (PCV) patients. METHODS: This prospective cohort study included 95 treatment-naïve patients that underwent anti-VEGF treatment for PCV for 12 months. Patients were genotyped for 10 single nucleotide polymorphisms in eight AMD-relevant genes...
December 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29210941/combined-autologous-transplantation-of-neurosensory-retina-retinal-pigment-epithelium-and-choroid-free-grafts
#6
Barbara Parolini, Dilraj S Grewal, Sajish J Pinackatt, Andrea Baldi, Attilio Di Salvatore, Gianluca Besozzi, Alessandro Finzi, Daniele Cardillo, Tamer H Mahmoud
PURPOSE: To evaluate the feasibility and initial functional and anatomical outcomes of transplanting a full-thickness free graft of choroid and retinal pigment epithelium (RPE), along with neurosensory retina in advanced fibrosis and atrophy associated with end-stage exudative age-related macular degeneration with and without a concurrent refractory macular hole. METHODS: During vitrectomy, an RPE-choroidal and neurosensory retinal free graft was harvested in nine eyes of nine patients...
November 23, 2017: Retina
https://www.readbyqxmd.com/read/29204996/the-vegf-treatment-of-amd-switch-study-the-vtas-study
#7
Beverley Curry, Guy Bylsma, Alex W Hewitt, Nitin Verma
PURPOSE: To evaluate the effect of aflibercept on anatomic and visual outcomes in patients with choroidal neovascularization (CNV) previously treated with intravitreal ranibizumab with persistent fluid on optical coherence tomography (OCT). DESIGN: Prospective, open-label study. METHODS: Eighteen patients (19 eyes) with CNV being treated with monthly ranibizumab, with persistent fluid on OCT, were switched to intravitreal aflibercept injections at intervals of up to 8 weeks...
November 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29200818/photodynamic-therapy-combined-with-antivascular-endothelial-growth-factor-treatment-for-recalcitrant-chronic-central-serous-chorioretinopathy
#8
Masumi G Asahi, Andrew T Chon, Esmeralda Gallemore, Ron P Gallemore
Purpose: To determine whether combination photodynamic therapy (PDT) and antivascular endothelial growth factor (VEGF) therapy is effective in the management of chronic central serous chorioretinopathy (CSC) recalcitrant to conventional therapy. Methods: This was a retrospective analysis of eight patients with chronic CSC unresponsive to topical nonsteroidal anti-inflammatory drugs, focal photocoagulation, anti-VEGF alone, or PDT alone. All patients were evaluated with a full ophthalmic examination, spectral-domain optical coherence tomography (OCT), fluorescein angiography (FA), and most with indocyanine green angiography (ICGA) followed by treatment with half-fluence PDT and intravitreal anti-VEGF injection (seven bevacizumab, one aflibercept)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29199012/choroidal-changes-after-suprachoroidal-injection-of-triamcinolone-in-eyes-with-macular-edema-secondary-to-retinal-vein-occlusion
#9
Alex S Willoughby, Vivian S Vuong, David Cunefare, Sina Farsiu, Glenn Noronha, Ronald P Danis, Glenn Yiu
PURPOSE: To evaluate choroidal and suprachoroidal changes following suprachoroidal injection of triamcinolone acetonide injectable suspension (CLS-TA), in eyes with macular edema due to retinal vein occlusion (RVO). DESIGN: Prospective cohort study within a randomized, controlled phase 2 clinical trial. METHODS: Enhanced-depth imaging optical coherence tomography (EDI-OCT) images were analyzed from 38 eyes of 38 treatment naïve patients with macular edema due to RVO, enrolled in the prospective Suprachoroidal Injection of Triamcinolone Acetonide with Intravitreal Aflibercept in Subjects with Macular Edema Due to Retinal Vein Occlusion (TANZANITE) study who received either a suprachoroidal injection of CLS-TA with an intravitreal injection of aflibercept (combination arm) or only an intravitreal injection of aflibercept (monotherapy arm) followed by monthly intravitreal aflibercept injections in both arms based on pro re nata (PRN) criteria...
November 30, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29196770/effect-of-gravity-acceleration-on-choroidal-and-retinal-nerve-fiber-layer-thickness-a-swept-source-optical-coherence-tomography-study
#10
Dong Yoon Kim, Jiho Song, Jin Young Kim, Kyungpil Choi, Sungmin Hyung, Ju Byung Chae
Purpose: The purpose of this study was to evaluate the effect of gravity acceleration on choroidal and retinal nerve fiber layer (RNFL) thickness using swept-source optical coherence tomography (SS-OCT). Methods: Thirteen healthy volunteers who planned to participate in human centrifuge training as part of the flight surgeon selection process enrolled this study. During centrifuge training, gravity was gradually increased up to six times that of sea level. All subjects underwent complete ophthalmologic examination and three-dimensional wide-scanning SS-OCT imaging (DRI OCT-1 Atlantis; Topcon, Tokyo, Japan)...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29196768/macular-atrophy-development-and-subretinal-drusenoid-deposits-in-anti-vascular-endothelial-growth-factor-treated-age-related-macular-degeneration
#11
Anna V Zarubina, Orly Gal-Or, Carrie E Huisingh, Cynthia Owsley, K Bailey Freund
Purpose: To explore the association between presence of subretinal drusenoid deposits (SDD) at baseline in eyes with neovascular age-related macular degeneration (nAMD) with the development of macular atrophy (MA) during anti-vascular endothelial growth factor (VEGF) therapy. Methods: There were 74 eyes without pre-existing MA receiving anti-VEGF therapy for nAMD for 2 years or longer analyzed. At least two image modalities that included spectral-domain optical coherence tomography, near-infrared reflectance, fluorescein angiography, and color fundus photos were used to assess for SDD presence, phenotype (dot and ribbon), and location, neovascularization type, and MA...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29193812/exploring-literature-based-definitions-of-hypotony-following-glaucoma-filtration-surgery-and-the-impact-on-clinical-outcomes
#12
Ali Abbas, Pavi Agrawal, Anthony J King
PURPOSE: To highlight the variations in published definitions of hypotony and their impact on reported clinical outcomes. To propose a revised definition, focusing on clinically significant hypotony (CH). METHODS: Literature review of hypotony definitions published between January 2010 and December 2015 was carried out. Numerical definitions for hypotony, its onset, duration and associated clinical signs were recorded. Each definition was applied to surgical outcomes data collected prospectively from a cohort of 300 glaucoma patients treated at a single centre...
November 29, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29191218/analysis-of-choroidal-and-central-foveal-thicknesses-in-acute-anterior-uveitis-by-enhanced-depth-imaging-optical-coherence-tomography
#13
Mirinae Kim, Seung Yong Choi, Young-Hoon Park
BACKGROUND: Currently, there are a limited number of reports of structural changes in the retina and choroid in acute anterior uveitis (AAU). The aim of this study was to evaluate choroidal and central foveal thicknesses during episodes of AAU. METHODS: The medical records of 120 patients with AAU and 120 healthy subjects matched for age, sex, and spherical equivalent of refractive error were reviewed. Subjects were divided into group 1 (AAU-affected eyes), 2 (unaffected fellow eyes), and 3 (healthy control eyes)...
December 1, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29190247/efficacy-of-double-dose-photodynamic-therapy-for-circumscribed-choroidal-hemangioma
#14
Ji Hwan Lee, Christopher Seungkyu Lee, Sung Chul Lee
PURPOSE: To evaluate the efficacy of photodynamic therapy using a double dose of verteporfin for patients with circumscribed choroidal hemangioma. METHODS: This retrospective comparative case series evaluated data from 10 patients who were treated using double dose photodynamic therapy (12 mg/m) and seven patients who were treated using the standard dose (6 mg/m). A laser was applied with a radiant exposure of 50 J/cm. The ophthalmologic examinations were performed at baseline and 1 year after the treatment and included best-corrected visual acuity, slit-lamp biomicroscopy, fundus examination, spectral domain optical coherence tomography, and B-scan ultrasonography...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29190246/optical-coherence-tomography-angiography-findings-of-deep-capillary-plexus-microischemia-after-intravenous-chemotherapy-for-retinoblastoma
#15
Kareem Sioufi, Emil A T Say, Sandor C Ferenczy, Ann M Leahey, Carol L Shields
PURPOSE: To study changes in the foveal microvascular anatomy using optical coherence tomography angiography (OCTA) after intravenous chemotherapy (IVC) for retinoblastoma (RB). METHODS: A retrospective comparative case-control series included 10 age-matched normal eyes with no documented ocular pathology (control), 10 fellow eyes of patients with unilateral RB treated with IVC (RB fellow), and 10 eyes with extramacular RB in patients with bilateral RB treated with IVC (RB tumor)...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29190243/factors-associated-with-serous-retinal-detachment-in-highly-myopic-eyes-with-vertical-oval-shaped-dome
#16
Antonio García-Ben, María J Morillo Sanchez, Ana Gonzalez Gómez, Ignacio García-Basterra, Antonio Soler García, Jose M García-Campos
PURPOSE: This study investigated factors associated with persistent serous retinal detachment in highly myopic eyes with vertical oval-shaped domes. METHODS: Twenty-eight highly myopic patients (40 eyes) with smooth macular elevations related to a vertical oval-shaped dome were recruited. Serous retinal detachment was investigated; 11 eyes had persistent submacular fluid (study group) and 29 eyes lacked submacular fluid (control group). All patients underwent complete ophthalmologic examinations, including axial-length measurement and fluorescein angiography...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29190170/the-role-of-dexamethasone-implant-in-the-management-of-tubercular-uveitis
#17
Aniruddha Agarwal, Sabia Handa, Kanika Aggarwal, Mansi Sharma, Ramandeep Singh, Aman Sharma, Rupesh Agrawal, Kusum Sharma, Vishali Gupta
PURPOSE: To study the safety and efficacy of intravitreal injection of dexamethasone implant in the management of posterior segment involvement in tubercular uveitis (TBU). METHODS: In this study, retrospective analysis of safety and efficacy of intravitreal injection of dexamethasone implant for various indications such as cystoid macular edema (CME), vitritis, or paradoxical worsening in TB-related intermediate uveitis, retinal vasculitis, and multifocal serpiginoid choroiditis (MSC) was performed...
November 30, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29188462/quantification-of-retinal-changes-after-resolution-of-submacular-hemorrhage-secondary-to-polypoidal-choroidal-vasculopathy
#18
Jae Hui Kim, Young Suk Chang, Dong Won Lee, Chul Gu Kim, Jong Woo Kim
PURPOSE: To evaluate changes in the thickness of retinal layers after resolution of submacular hemorrhage secondary to polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective, observational study. METHODS: This study included 21 patients (21 eyes) who had been diagnosed with submacular hemorrhage secondary to PCV and treated using anti-vascular endothelial growth factor monotherapy. After the hemorrhage had resolved, the thicknesses of the retinal layers were measured on horizontal- and vertical-crosshair optical coherence tomography scan images...
November 29, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29185835/biometric-differences-between-unilateral-chronic-primary-angle-closure-glaucoma-and-fellow-non-glaucomatous-eyes
#19
Wei Wang, Xinyi Li, Shida Chen, Wenbin Huang, Xiulan Zhang
PURPOSE: To compare biometric differences between eyes with unilateral chronic primary angle-closure glaucoma (PACG) and fellow non-glaucomatous eyes in the same patient. METHODS: Clinical data and imaging records of 17 patients with unilateral PACG were retrospectively reviewed. The fellow eyes with primary angle-closure (PAC) or primary angle-closure suspected (PACS) were grouped in Group 1. The PACG eyes were set as Group 2. The biometric parameters of both eyes were measured by IOL-Master, anterior segment optical coherence tomography (AS-OCT), and swept source OCT...
November 29, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29181329/comment-on-the-diurnal-variation-pattern-of-choroidal-thickness-in-macular-region-of-young-healthy-female-individuals-using-spectral-domain-optical-coherence-tomography
#20
Salih Uzun, Emre Pehlivan, Mehmet Gulmez
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
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