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Choroidal thickness

Ryusaburo Mori, Koji Tanaka, Mitsuko Yuzawa
This study aimed to explore predictors of long-term stabilization of polypoidal choroidal vasculopathy (PCV) lesions and vision in response to injection of intravitreal ranibizumab (IVR). The treated eyes had a baseline best corrected visual acuity (BCVA) of at least 0.6 (logarithm of the minimal angle of resolution (logMAR) 0.22).We treated 45 eyes showing BCVA between 0.6 (logMAR 0.22) and 1.0 (logMAR 0), with IVR for 3 consecutive months. All eyes were confirmed to have subfoveal PCV prior to starting this treatment regimen...
June 2018: Medicine (Baltimore)
Lauren A Dalvin, David Ancona-Lezama, J Antonio Lucio-Alvarez, Babak Masoomian, Pascal Jabbour, Carol L Shields
PURPOSE: To assess risk factors for ophthalmic vascular events after intra-arterial chemotherapy (IAC) for retinoblastoma. DESIGN: Retrospective cohort study. PARTICIPANTS: Patients who received unilateral IAC as primary treatment for retinoblastoma from January 1, 2009, to November 30, 2017, at a single center. METHODS: Records were reviewed for patient demographics, tumor features, IAC parameters, and treatment-related vascular events in the early IAC era (2009-2011) compared with the recent era (2012-2017) using the t test and Fisher exact test...
June 16, 2018: Ophthalmology
Raimondo Forte, Florent Aptel, Kim Thia-Soui-Tchong, Lenore Salmon, Adriane Mailhac, Laurence Bouillet, Christophe Chiquet
PURPOSE: To evaluate 2-year choroidal changes in eyes with birdshot retinochoroiditis (BRC). METHODS: Thirteen patients (26 eyes) with BRC were prospectively evaluated during a 2-year period with standard automated perimetry (SAP), fluorescein angiography, indocyanine green angiography and optical coherence tomography (Spectralis Heidelberg Retinal Angiograph + optical coherence tomography). Enhanced-depth imaging optical coherence tomography was performed. RESULTS: Eight patients (61%) were females; the patients mean age was 60 ± 4...
June 19, 2018: Ophthalmologica. Journal International D'ophtalmologie
Qian Wang, Szy Yann Chan, Yanni Yan, Jingyan Yang, Wenjia Zhou, Jost B Jonas, Wen Bin Wei
PURPOSE: To examine the vascular density in different retinal layers and in the choriocapillaris in eyes with retinal vein occlusions (RVO). METHODS: Applying optical coherence tomography angiography (OCTA), we examined patients with unilateral RVOs and normal individuals of a control group. RESULTS: The study group included 48 patients with unilateral RVO and the control group 17 normal individuals. Eyes affected by RVO as compared to the contralateral unaffected eyes (all P < 0...
June 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Chikako Hara, Taku Wakabayashi, Hiroshi Toyama, Yoko Fukushima, Kaori Sayanagi, Shigeru Sato, Hirokazu Sakaguchi, Kohji Nishida
PURPOSE: To investigate the frequency and patient characteristics that influence anatomic response of intravitreal aflibercept in treatment-naïve neovascular age-related macular degeneration (AMD). DESIGN: Retrospective, interventional, consecutive case series. METHODS: Three hundred and sixty-five eyes of 365 patients with AMD who underwent 3 monthly intravitreal aflibercept treatments with follow-up for at least 12 months were investigated...
June 15, 2018: British Journal of Ophthalmology
Rupak Roy, Kumar Saurabh, Chinmayi Vyas, Kaustubh Deshmukh, Preeti Sharma, Dhileesh P Chandrasekharan, Aditya Bansal
AIM: This study aims to study normative choroidal thickness (CT) and Haller's and Sattler's layers thickness in normal Indian eyes. MATERIALS AND METHODS: The choroidal imaging of 73 eyes of 43 healthy Indian individuals was done using enhanced depth imaging feature of spectralis optical coherence tomography. Rraster scan protocol centered at fovea was used for imaging separately by two observers. CT was defined as the length of the perpendicular line drown from the outer border of hypereflective RPE-Bruch's complex to inner margin of choroidoscleral junction...
January 2018: Middle East African Journal of Ophthalmology
Qader Motarjemizadeh, Naser Samadi Aidenloo, Mohammad Abbaszadeh, Vahid Sadrinia
PURPOSE: The purpose of this study is to compare the long-term outcomes of intravitreal bevacizumab (IVB) with a combination therapy including IVB/intravitreal triamcinolone acetonide (IVB/IVTA) in neovascular age-related macular degeneration (AMD). MATERIALS AND METHODS: This prospective, randomized clinical trial was conducted on 136 eyes of 136 patients with neovascular AMD. Eyes were randomly assigned to receive IVB alone (71 eyes) or in combination with IVTA (65 eyes)...
January 2018: Middle East African Journal of Ophthalmology
Rosa Gutierrez-Bonet, Jorge Ruiz-Medrano, Pablo Peña-Garcia, Muriel Catanese, Yalda Sadeghi, Katayoon Hashemi, Eric Gabison, José M Ruiz-Moreno
Purpose: To determine the choroidal thickness (CT) profile in keratoconus (KC) patients using swept-source optical coherence tomography (SS-OCT). Methods: This was a prospective, cross-sectional study. One hundred two eyes of 52 KC patients were studied using Pentacam and SS-OCT. The macular CT profile was created by manually measuring the distance between the retinal pigment epithelium and the choroid-sclera junction on horizontal b-scans at nine different macular locations...
May 2018: Translational Vision Science & Technology
Wei Chen, Li Li, Hongyuan Zhang, Yan Li, Xu Chen, Yue Zhang
BACKGROUND: High myopia, a cause of serious visual impairment, is a significant global public health concern. We investigate longitudinal changes in macular choroidal thickness (CT) during pregnancy and 6-months postpartum in women with high myopia (HM). METHODS: A prospective longitudinal study was conducted in HM-pregnant women during the course of pregnancy (n = 42 eyes, 42 patients) and 6 months postpartum (n = 40 eyes, 40 patients, two cases lost)...
June 8, 2018: BMC Pregnancy and Childbirth
Ji-Hye Park, Chungkwon Yoo, Yong Yeon Kim
The aim of this study was to evaluate the regional variations of peripapillary choroidal thickness (PCT) in normal-tension glaucoma (NTG) patients with a retinal nerve fiber layer (RNFL) defect localized to a single superior or inferior hemifield. This is a retrospective, cross-sectional study.Ninety-five NTG patients and 53 normal subjects were divided into 3 groups: 34 eyes with a superior RNFL defect (group A), 61 eyes with an inferior RNFL defect (group B), and 53 normal eyes (group C). The average, quadrant, and clock-hour RNFL thickness (RNFLT) and PCT were measured using spectral-domain optical coherence tomography...
June 2018: Medicine (Baltimore)
Paolo Milani, Giovanni Montesano, Luca Rossetti, Fulvio Bergamini, Alfredo Pece
PURPOSE: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. METHODS: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. RESULTS: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1...
June 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Hajnalka Horváth, Illés Kovács, Gábor László Sándor, Cecília Czakó, Klaudia Mallár, Zsuzsanna Récsán, Anikó Somogyi, Zoltán Zsolt Nagy, Mónika Ecsedy
AIMS: To measure choroidal thickness (CT) in diabetic eyes and its correlation with metabolic status and the severity of diabetic retinopathy (DR). MATERIALS AND METHODS: Prospective cross-sectional study using swept-source optical coherence tomography. CT maps of 96 treatment naïve eyes of 48 patients with diabetes were compared to 46 eyes of 23 healthy controls. CT changes and their relation to diabetes, age, gender, disease duration, hypertension (HT), hemoglobin A1c level, type and severity of DR were evaluated...
June 6, 2018: Acta Diabetologica
Manabu Miyata, Sotaro Ooto, Kenji Yamashiro, Hiroshi Tamura, Masayuki Hata, Naoko Ueda-Arakawa, Munemitsu Yoshikawa, Shogo Numa, Akitaka Tsujikawa
BACKGROUND/AIMS: To evaluate the 5-year visual and anatomical outcomes after anti-vascular endothelial growth factor (VEGF) therapy alone or in combination with photodynamic therapy (PDT), followed by pro re nata (PRN) anti-VEGF therapy with or without PDT, for polypoidal choroidal vasculopathy (PCV). METHODS: This retrospective, observational study included 61 consecutive patients with treatment-naïve symptomatic PCV who were followed for 5 years. Twenty eyes (20 patients) initially received PDT and intravitreal injection of ranibizumab (IVR), followed by a PRN regimen of anti-VEGF therapy with or without PDT (combination group), while 41 eyes (41 patients) initially received only IVR every 3 months, followed by a PRN regimen of anti-VEGF monotherapy (IVR group)...
June 6, 2018: British Journal of Ophthalmology
Hongjie Mu, Yiyun Wang, Yongchao Chu, Ying Jiang, Hongchen Hua, Liuxiang Chu, Kaili Wang, Aiping Wang, Wanhui Liu, Youxin Li, Fenghua Fu, Kaoxiang Sun
Bevacizumab is an anti-vascular endothelial growth factor drug that can be used to treat choroidal neovascularization (CNV). Bevacizumab-loaded multivesicular liposomes (Bev-MVLs) have been designed and developed to increase the intravitreal retention time of bevacizumab and reduce the number of injection times. In this study, Bev-MVLs with high encapsulation efficiency were prepared by double emulsification technique, and antibody activity was determined. The results revealed that 10% of human serum albumin (HSA) could preserve the activity of bevacizumab...
November 2018: Drug Delivery
Fatih Horozoğlu, Sever Özkan
BACKGROUND: Intravitreal steroid injection is one of the treatment choices in diabetic macular edema (DME). Dexamethasone (Dx) implant is the most novel form of intravitreal steroid therapy. Macular thickness improvement is well known effect of Dx implant however; subfoveal choroidal coat thickness (SFCT) changes need to be investigated. AIMS: To evaluate the early central macular thickness (CMT) and SFCT alterations after single dose dexamethasone implant injection in DME...
June 5, 2018: Balkan Medical Journal
Yucel Karakurt, Turgay Ucak, Gamze Tasli, Ibrahim Ahiskali, Sare Şipal, Nezahat Kurt, Halis Süleyman
AIM: Lutein is one of the most common carotenoids defined in human plasma as having potent anti-oxidant effects. We aimed to determine the biochemical and histopathological effects of lutein on cisplatin induced oxidative retinal injury in rats. MATERIAL AND METHOD: Twenty-four rats were equally divided into four groups as healthy controls (HC group), only cisplatin (5 mg/kg) administered group (CIS group), Lutein (0.5 mg/kg) + cisplatin (5 mg/kg) administered group (LC group), and only Lutein (0...
June 4, 2018: Cutaneous and Ocular Toxicology
Marco Pellegrini, Federico Corvi, Alessandro Invernizzi, Vittoria Ravera, Matteo G Cereda, Giovanni Staurenghi
PURPOSE: To describe the imaging features of choroidal melanoma using swept-source optical coherence tomography angiography (SS-OCT-A) and to evaluate its ability to display tumor intrinsic vasculature. METHODS: Consecutive patients diagnosed with choroidal melanoma underwent a complete ophthalmic evaluation, including best-corrected visual acuity, color fundus photography, B-scan ultrasound, fluorescein angiography, indocyanine green angiography, and SS-OCT-A (PLEX Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA)...
May 8, 2018: Retina
Jae Hyung Lee, Jun Yong Kim, Byung Ju Jung, Won Ki Lee
PURPOSE: To describe a distinctive focal disruption of the ellipsoid zone (EZ)/interdigitation zone (IZ) determined by spectral-domain optical coherence tomography in eyes with pachychoroid pigment epitheliopathy. METHODS: Twenty patients with focal EZ/IZ disruptions associated with pachychoroid without history or findings indicative of subretinal fluid were evaluated. Detailed clinical/imaging characteristics and their longitudinal changes were evaluated. RESULTS: A total of 27 lesions from 21 eyes were included...
May 8, 2018: Retina
Yang Lyu, Wen-Qin Xu, Li-Juan Sun, Xiao-Yan Pan, Jian Zhang, Yu-Sheng Wang
AIM: To investigate the roles of integrins in choroidal neovascularization (CNV) and their associations with the stromal cell-derived factor-1 (SDF-1)/CXCR4 axis. METHODS: CNV lesions were induced in mice using laser photocoagulation. After CNV induction, all animals were randomly assigned to: control, SDF-1, SDF-1+age-related macular degeneration (AMD) 3100 (CXCR4 inhibitor), and SDF-1+ATN161 (integrin α5β1 inhibitor) groups; their effects on CNV progression were observed using hematoxylin eosin (HE) staining, fundus fluorescein angiography (FFA) grading and optical coherence tomography (OCT), and their effects on CXCR4/integrin α5 expression were evaluated using Western blot and double immunofluorescence staining...
2018: International Journal of Ophthalmology
Mi Sun Sung, Hwan Heo, Sang Woo Park
PURPOSE: To evaluate the clinical characteristics of β-PPA in myopic eyes and determine whether the microstructure of β-PPA is associated with parapapillary microvasculature by using optical coherence tomography (OCT) angiography. DESIGN: Cross-sectional study METHODS: This study included 80 subjects with myopia with β-PPA. Spherical equivalent (SE) refractive error, axial length, horizontal tilt angle, and the width of β-PPA were evaluated. The microstructure of β-PPA and subfoveal choroidal thickness were evaluated using enhanced-depth imaging OCT and eyes were classified into 3 groups based on the presence of Bruch's membrane (BM), a PPA+BM only group, a PPA+BM and PPA-BM group, and a PPA-BM only group...
May 30, 2018: American Journal of Ophthalmology
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