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Choroidal thickness

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https://www.readbyqxmd.com/read/27926751/ocular-perfusion-pressure-and-choroidal-thickness-in-early-age-related-macular-degeneration-patients-with-reticular-pseudodrusen
#1
Cheolmin Yun, Jaemoon Ahn, Minjung Kim, Soon-Young Hwang, Seong-Woo Kim, Jaeryung Oh
Purpose: The purpose of this study was to investigate the relationship between the ocular perfusion pressure (OPP) and subfoveal choroidal thickness (CT) in eyes with early age-related macular degeneration (AMD) with or without reticular pseudodrusen (RPD). Methods: We evaluated the clinical history, blood pressure parameters, fundus photography, and optical coherence tomography images of consecutive patients with early AMD. We calculated the mean OPP from blood pressure and intraocular pressure...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27918828/peripapillary-choroidal-thickness-in-former-preterm-and-full-term-infants-aged-from-4-to-10-years
#2
Achim Fieß, Luka Christian, Ruth Kölb-Keerl, Markus Knuf, Bernd Kirchhof, Philipp S Muether, Jacqueline Bauer
Purpose: The aim of the study was to investigate peripapillary choroidal thickness in former preterm and full-term infants with spectral-domain optical coherence tomography (SD-OCT). Methods: Subanalysis of infants with successful peripapillary choroidal thickness measurements of a prospective, controlled, cross-sectional, hospital-based study in a tertiary center of maximum care. The study examined 503 infants aged 4 to 10 years at the time of examination. Infants were divided into different groups: group 1 born with gestational age (GA) ≥37 weeks, group 2 born with GA between 29 and 32 weeks without ROP (retinopathy of prematurity), group 3 born with GA ≤28 weeks without ROP, and group 4 born with GA ≤32 weeks and presence of ROP...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27918826/long-term-protection-of-genetically-ablated-rabbit-retinal-degeneration-by-sustained-transscleral-unoprostone-delivery
#3
Nobuhiro Nagai, Eri Koyanagi, Yasuko Izumida, Junjun Liu, Aya Katsuyama, Hirokazu Kaji, Matsuhiko Nishizawa, Noriko Osumi, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toru Nakazawa, Toshiaki Abe
Purpose: To evaluate the long-term protective effects of transscleral unoprostone (UNO) against retinal degeneration in transgenic (Tg) rabbits (Pro347Leu rhodopsin mutation). Methods: The UNO release devices (URDs) were implanted into the sclerae of Tg rabbits and ERG, optical coherence tomography (OCT), and ophthalmic examinations were conducted for 40 weeks. Unoprostone metabolites in retina, choroid/RPE, aqueous humor, and plasma from wild-type (Wt) rabbits were measured using liquid chromatography-tandem mass spectrometry...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27913869/ranibizumab-for-vascularized-pigment-epithelial-detachment-1-year-anatomic-and-functional-results
#4
Olivier Chevreaud, Hassiba Oubraham, Salomon Y Cohen, Camille Jung, Rocio Blanco-Garavito, Farah Gherdaoui, Eric H Souied
PURPOSE: To assess the anatomical and functional efficacy of ranibizumab on vascularized pigment epithelial detachment (V-PED) secondary to neovascular age-related macular degeneration (nAMD). METHODS: One hundred and nine patients (116 eyes) were retrospectively selected from medical records of 2097 patients who benefited from intravitreal injection between January 2011 and June 2013 in a tertiary-care University-based Department of Ophthalmology. Inclusion criteria were: nAMD, treatment-naive eyes, presence of V-PED higher than 250 μm, intravitreal ranibizumab with a loading phase, followed by a pro-re-nata regimen, and 1-year follow-up...
December 3, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27911444/impact-of-optical-coherence-tomography-scanning-density-on-quantitative-analyses-in-neovascular-age-related-macular-degeneration
#5
S B Velaga, M G Nittala, R K Konduru, F Heussen, P A Keane, S R Sadda
PurposeTo assess the influence of varying B-scan frame-sampling densities on retinal thickness and volume measurements from spectral domain optical coherence tomography (OCT) in eyes with neovascular age-related macular degeneration (AMD).MethodsVolume OCT data (512 × 128 macular cube over 6 × 6 mm) were collected from 39 eyes with neovascular AMD. All 128 B-scans in each image set were manually segmented, allowing quantification of the neurosensory retina, subretinal fluid (SRF), subretinal hyperreflective material (SRHM), and pigment epithelium detachment (PED)...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27908566/update-of-choroidal-imaging-techniques-past-present-and-future
#6
J Ruiz-Medrano, I Flores-Moreno, R Gutierrez-Bonet, J Chhablani, J M Ruiz-Moreno
The choroid is the middle layer of the eye, a very vascular and pigmented tissue, with its role in several ophthalmological pathologies already having been clearly established. But it was not until the last few years that we have been able to reliably and precisely measure and quantify its shape and thickness. Ultrasound technology and indocyanine green angiography were the first techniques used for the study of the choroid, and they still maintain their use and clinical indications for the diagnosis and management of several pathologies...
November 28, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27905337/choroidal-thickness-evaluation-of-healthy-eyes-central-serous-chorioretinopathy-and-fellow-eyes-using-spectral-domain-optical-coherence-tomography-in-indian-population
#7
Supriya Arora, Richa Pyare, Preethi Sridharan, Tarun Arora, Meenakshi Thakar, Basudeb Ghosh
AIM: The purpose of this study is to establish a normative database of subfoveal choroidal thickness (CT) in healthy young Indians using spectral domain optical coherence tomography (SD OCT). Evaluation and comparison of CT of central serous chorioretinopathy (CSC) and fellow eyes were also performed. MATERIALS AND METHODS: This was a prospective, cross-sectional, and observational study. It included 112 normal eyes of 112 healthy volunteers who had no evidence of ocular or systemic disease, 84 CSC eyes with acute, treatment-naïve CSC, and 69 fellow eyes with no evidence of neurosensory detachment or pigment epithelium detachment on SD OCT...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898981/macular-features-in-retinitis-pigmentosa-correlations-among-ganglion-cell-complex-thickness-capillary-density-and-macular-function
#8
Lisa Toto, Enrico Borrelli, Rodolfo Mastropasqua, Alfonso Senatore, Luca Di Antonio, Marta Di Nicola, Paolo Carpineto, Leonardo Mastropasqua
Purpose: To investigate correlations among macular ganglion cell complex (GCC) layer thickness, macular capillary density, and macular function in patients affected by retinitis pigmentosa (RP). Methods: Fourteen patients (28 eyes) with previous diagnosis of RP were enrolled. The diagnosis of these conditions was made based on both clinical features and electrophysiological examination. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography (OCTA) and multifocal electroretinogram (mfERG)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27893887/retinal-neurodegeneration-in-diabetic-patients-without-diabetic-retinopathy
#9
Joana Tavares Ferreira, Marta Alves, Arnaldo Dias-Santos, Lívio Costa, Bruno Oliveira Santos, João Paulo Cunha, Ana Luísa Papoila, Luís Abegão Pinto
Purpose: To compare the thickness of all retinal layers between a nondiabetic group and diabetic patients without diabetic retinopathy (DR). Methods: Cross-sectional study, in which all subjects underwent an ophthalmic examination including optical coherence tomography. After automatic retinal segmentation, each retinal layer thickness (eight separate layers and overall thickness) was calculated in all nine Early Treatment Diabetic Retinopathy Study (ETDRS) areas...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27893621/choroidal-changes-associated-with-serous-macular-detachment-in-eyes-with-staphyloma-dome-shaped-macula-or-tilted-disk-syndrome
#10
Anna C S Tan, Suzanne Yzer, K Bailey Freund, Kunal K Dansingani, Nopasak Phasukkijwatana, David Sarraf
PURPOSE: To study the relationship of choroidal abnormalities with serous retinal detachment (SRD) in eyes with staphyloma, dome-shaped macula, or tilted disk syndrome. METHODS: Group 1, 28 eyes of 20 patients with staphyloma/dome-shaped macula/tilted disk syndrome associated with SRD was compared with Group 2, 30 eyes of 20 patients, with staphyloma/dome-shaped macula/tilted disk syndrome but without SRD. Radial and en-face optical coherence tomography and choroidal analysis were performed...
November 23, 2016: Retina
https://www.readbyqxmd.com/read/27893108/choroidal-thickness-influences-near-infrared-reflectance-intensity-in-eyes-with-geographic-atrophy-due-to-age-related-macular-degeneration
#11
Rosa Dolz-Marco, Orly Gal-Or, K Bailey Freund
Purpose: To evaluate the effects of retinal and choroidal thickness on near-infrared reflectance (NIR) scanning laser ophthalmoscopy in eyes with geographic atrophy (GA) secondary to non-neovascular age-related macular degeneration (AMD). Methods: This was a cross-sectional review of the clinical records and multimodal imaging data of eyes diagnosed with GA secondary to non-neovascular AMD. Imaging modalities included color fundus photography, fundus autofluorescence, NIR, and structural spectral-domain optical coherence tomography (SD-OCT)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27892746/choroidal-neovascularization-associated-with-multiple-evanescent-white-dot-syndrome-treated-with-intravitreal-ranibizumab
#12
Maurizio Battaglia Parodi, Pierluigi Iacono, Ilaria Zucchiatti, Francesco Bandello
PURPOSE: To describe the clinical outcomes of intravitreal ranibizumab treatment for subfoveal choroidal neovascularization (CNV) associated with multiple evanescent white dot syndrome (MEWDS). METHODS: This is a prospective, interventional, case series. All recruited patients underwent a baseline intravitreal ranibizumab injection and were monitored monthly over a 12-month follow-up, following a pro-re-nata regimen. RESULTS: Four patients (four eyes) were included in the study...
November 28, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27881909/comparison-of-choroidal-thickness-measurements-between-spectral-domain-oct-and-swept-source-oct-in-normal-and-diseased-eyes
#13
Sidra Zafar, Ma Rehman Siddiqui, Rida Shahzad
PURPOSE: Sub-foveal choroidal thickness (SFCT) is affected in many ocular diseases. The aim of this study was to compare SFCT measurements between Topcon 3D 2000 spectral-domain optical coherence tomography (SD-OCT) and Topcon swept-source OCT (SS-OCT), with different laser wavelengths, in normal and diseased populations. MATERIALS AND METHODS: This was a prospective, cross-sectional, noninterventional study including 27 normal volunteers and 27 participants with retinal disease...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27875364/attenuation-of-choroidal-thickness-in-patients-with-alzheimer-disease-evidence-from-an-italian-prospective-study
#14
Alessandro Trebbastoni, Michela Marcelli, Fabiana Mallone, Fabrizia D'Antonio, Letizia Imbriano, Alessandra Campanelli, Carlo de Lena, Magda Gharbiya
INTRODUCTION: To compare the 12-month choroidal thickness (CT) change between Alzheimer disease (AD) patients and normal subjects. METHODS: In this prospective, observational study, 39 patients with a diagnosis of mild to moderate AD and 39 age-matched control subjects were included. All the subjects underwent neuropsychological (Mini Mental State Examination, Alzheimer disease Assessment Scale-Cognitive Subscale, and the Clinical Dementia Rating Scale) and ophthalmological evaluation, including spectral domain optical coherence tomography, at baseline and after 12 months...
November 21, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27870799/choroidal-thickness-changes-after-intravitreal-dexamethasone-implant-injection-for-the-treatment-of-macular-edema-due-to-retinal-vein-occlusion
#15
Ebru Esen, Selcuk Sizmaz, Nihal Demircan
PURPOSE: To investigate changes in choroidal thickness after intravitreal injection of a dexamethasone implant for macular edema due to retinal vein occlusion. METHODS: Thirty-one eyes of 31 patients, treated with a single dose of a dexamethasone implant for retinal vein occlusion-associated macular edema, were included. Subfoveal choroidal thickness (SFCT) and central macular thickness of the affected eyes were compared with those of the normal contralateral eyes at baseline and 1, 3, and 5 months after injection...
December 2016: Retina
https://www.readbyqxmd.com/read/27864836/choroidal-and-central-foveal-thickness-in-patients-with-scleroderma-and-its-systemic-associations
#16
Erdinc Aydin, Sevinc Atik, Feray Koc, Melike Balikoglu-Yilmaz, Sirin Akin Sari, Mustafa Ozmen, Servet Akar
BACKGROUND: The aim was to investigate the morphological changes in the fovea and choroid in patients with scleroderma and its systemic associations. METHODS: Thirty-four scleroderma patients and 31 healthy controls were enrolled. Choroidal thickness (CT) at five defined points (subfoveal [sfCT] and 1.0 [N1.0] and 3.0 µm nasal [N3.0] and 1.0 [T1.0] and 3.0 µm temporal [T3.0] from the centre of the fovea) and central foveal thickness were measured. RESULTS: The mean central foveal thickness (right eye 229...
November 18, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27863845/macular-atrophy-in-neovascular-age-related-macular-degeneration-with-monthly-versus-treat-and-extend-ranibizumab-findings-from-the-trex-amd-trial
#17
Nizar S Abdelfattah, Mayss Al-Sheikh, Sean Pitetta, Ahmed Mousa, SriniVas R Sadda, Charles C Wykoff
PURPOSE: To compare the enlargement rate of macular atrophy (ERMA) in eyes treated with ranibizumab monthly or using a treat-and-extend (TREX) regimen for neovascular age-related macular degeneration (AMD) or fellow control eyes, as well as analyze risk factors for macular atrophy (MA) development and progression. DESIGN: Eighteen-month, multicenter, randomized, controlled clinical trial. PARTICIPANTS: Sixty patients with treatment-naïve neovascular AMD in 1 eye randomized 1:2 to monthly or TREX ranibizumab...
November 15, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27862073/n-methyl-n-nitrosourea-induces-retinal-degeneration-in-the-rat-via-the-inhibition-of-nf-%C3%AE%C2%BAb-activation
#18
Yu Xiong, Hong-Pei Ji, Wei-Tao Song, Ye-Wei Yin, Chao-Hua Xia, Bei Xu, Yi Xu, Xiao-Bo Xia
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by the loss of photoreceptor cells through apoptosis. N-methyl-N-nitrosourea (MNU) is an alkylating toxicant that induces photoreceptor cell death resembling hereditary RP. This study aimed to investigate the role of nuclear factor κB (NF-κB) in MNU-induced photoreceptor degeneration. Adult rats received a single intraperitoneal injection of MNU (60 mg/kg bodyweight). Hematoxylin and eosin staining demonstrated progressive outer nuclear layer (ONL) loss after MNU treatment...
November 13, 2016: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/27853350/intravitreal-aflibercept-for-the-treatment-of-choroidal-neovascularization-associated-with-pathologic-myopia-a-pilot-study
#19
Andrii R Korol, Oleg S Zadorozhnyy, Volodymyr O Naumenko, Taras B Kustryn, Nataliya V Pasyechnikova
PURPOSE: To determine the efficacy of intravitreal aflibercept injections for the treatment of patients with choroidal neovascularization (CNV) associated with pathologic myopia. METHODS: In this uncontrolled, prospective cohort study, 31 eyes of 30 consecutive patients affected by CNV associated with pathologic myopia were treated with intravitreal aflibercept (2 mg) as needed following two initial monthly doses and observed over a 12-month follow-up period. The primary endpoint was change in best-corrected visual acuity (BCVA) at month 12, while central retinal thickness (CRT) on optical coherence tomography (OCT), neovascularization activity on fluorescein angiography, the number of aflibercept injections administered, and safety were examined as secondary endpoints...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27853297/changes-in-choroidal-thickness-follow-the-rnfl-changes-in-leber-s-hereditary-optic-neuropathy
#20
Enrico Borrelli, Giacinto Triolo, Maria Lucia Cascavilla, Chiara La Morgia, Giovanni Rizzo, Giacomo Savini, Nicole Balducci, Paolo Nucci, Rosa Giglio, Fatemeh Darvizeh, Vincenzo Parisi, Francesco Bandello, Alfredo A Sadun, Valerio Carelli, Piero Barboni
Leber's hereditary optic neuropathy (LHON) is typically characterized by vascular alterations in the acute phase. The aim of this study was to evaluate choroidal changes occurring in asymptomatic, acute and chronic stages of LHON. We enrolled 49 patients with LHON, 19 with Dominant Optic Atrophy (DOA) and 22 healthy controls. Spectral Domain-Optical Coherence Tomography (SD-OCT) scans of macular and peripapillary regions were performed in all subjects, to evaluate macular and peripapillary choroidal thickness, and retinal nerve fiber layer (RNFL) thicknes...
November 17, 2016: Scientific Reports
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