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Fernando baquero

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https://www.readbyqxmd.com/read/29224998/neonatal-epididymo-orchitis-with-pyocele-caused-by-escherichia-coli-successful-treatment-with-antimicrobial-therapy-alone
#1
David Aguilera-Alonso, Teresa Del Rosal, Sara Pérez Muñoz, Fernando Baquero-Artigao
No abstract text is available yet for this article.
December 7, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29184022/interventions-on-metabolism-making-antibiotic-susceptible-bacteria
#2
Fernando Baquero, José-Luis Martínez
Antibiotics act on bacterial metabolism, and antibiotic resistance involves changes in this metabolism. Interventions on metabolism with drugs might therefore modify drug susceptibility and drug resistance. In their recent article, Martin Vestergaard et al. (mBio 8:e01114-17, 2017, https://doi.org/10.1128/mBio.01114-17) illustrate the possibility of converting intrinsically resistant bacteria into susceptible ones. They reported that inhibition of a central metabolic enzyme, ATP synthase, allows otherwise ineffective polymyxin antibiotics to act on Staphylococcus aureus The study of the intrinsic resistome of bacterial pathogens has shown that several metabolic genes, including multigene transcriptional regulators, contribute to antibiotic resistance...
November 28, 2017: MBio
https://www.readbyqxmd.com/read/29136422/transmission-as-a-basic-process-in-microbial-biology-lwoff-award-prize-lecture
#3
Fernando Baquero
Transmission is a basic process in biology and evolution, as it communicates different biological entities within and across hierarchical levels (from genes to holobionts) both in time and space. Vertical descent, replication, is transmission of information across generations (in the time dimension), and horizontal descent is transmission of information across compartments (in the space dimension). Transmission is essentially a communication process that can be studied by analogy of the classic information theory, based on 'emitters', 'messages' and 'receivers'...
November 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28951476/individual-patterns-of-complexity-in-cystic-fibrosis-lung-microbiota-including-predator-bacteria-over-a-1-year-period
#4
Juan de Dios Caballero, Rafael Vida, Marta Cobo, Luis Máiz, Lucrecia Suárez, Javier Galeano, Fernando Baquero, Rafael Cantón, Rosa Del Campo
Cystic fibrosis (CF) lung microbiota composition has recently been redefined by the application of next-generation sequencing (NGS) tools, identifying, among others, previously undescribed anaerobic and uncultivable bacteria. In the present study, we monitored the fluctuations of this ecosystem in 15 CF patients during a 1-year follow-up period, describing for the first time, as far as we know, the presence of predator bacteria in the CF lung microbiome. In addition, a new computational model was developed to ascertain the hypothetical ecological repercussions of a prey-predator interaction in CF lung microbial communities...
September 26, 2017: MBio
https://www.readbyqxmd.com/read/28859345/basic-sciences-fertilizing-clinical-microbiology-and-infection-management
#5
Fernando Baquero
Basic sciences constitute the most abundant sources of creativity and innovation, as they are based on the passion of knowing. Basic knowledge, in close and fertile contact with medical and public health needs, produces distinct advancements in applied sciences. Basic sciences play the role of stem cells, providing material and semantics to construct differentiated tissues and organisms and enabling specialized functions and applications. However, eventually processes of "practice deconstruction" might reveal basic questions, as in de-differentiation of tissue cells...
August 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28859340/rewiring-microbiology-and-infection
#6
Didier Raoult, Fernando Baquero
No abstract text is available yet for this article.
August 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28843668/phagocytes-antibiotics-and-self-limiting-bacterial-infections
#7
REVIEW
Bruce R Levin, Fernando Baquero, Peter Pierre Ankomah, Ingrid C McCall
Most antibiotic use in humans is to reduce the magnitude and term of morbidity of acute, community-acquired infections in immune competent patients, rather than to save lives. Thanks to phagocytic leucocytes and other host defenses, the vast majority of these infections are self-limiting. Nevertheless, there has been a negligible amount of consideration of the contribution of phagocytosis and other host defenses in the research for, and the design of, antibiotic treatment regimens, which hyper-emphasizes antibiotics as if they were the sole mechanism responsible for the clearance of infections...
November 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28729186/-tuberculosis-treatment-for-children-an-update
#8
María José Mellado Peña, Begoña Santiago García, Fernando Baquero-Artigao, David Moreno Pérez, Roi Piñeiro Pérez, Ana Méndez Echevarría, José Tomás Ramos Amador, David Gómez-Pastrana Durán, Antoni Noguera Julian
Tuberculosis (TB) is the most important infectious disease all over the world, with a high morbidity and mortality. Pediatric tuberculosis has been a neglected epidemic, due to the difficulties in assessing its global impact, reduced incidence and lower infectivity compared to adults. In 2015, the WHO reported 1 million cases of paediatric TB and 169,000 deaths. In Europe, the emergence of MDR TB is a major concern, representing 16% of the new diagnosis in Eastern Europe. In 2014, it was estimated that about 219,000 children were infected by MDR-TB-strains in Europe, and 2,120 developed the disease...
July 18, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28711388/impact-of-13-valent-pneumococcal-conjugate-vaccine-on-pneumococcal-meningitis-in-children
#9
Jesus Ruiz-Contreras, Juan Picazo, Juan Casado-Flores, Fernando Baquero-Artigao, Teresa Hernández-Sampelayo, Enrique Otheo, Cristina Méndez, María Del Amo, César Balseiro
OBJECTIVES: To evaluate the impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in children. METHODS: Children younger than 15years of age attending 27 hospitals in the Region of Madrid with confirmed pneumococcal meningitis were identified in a prospective surveillance study, from 2007 to 2015. Clinical data, neurological sequelae, pneumococcal vaccination status, serotyping and antibiotic susceptibility were recorded. RESULTS: One hundred and four cases of pneumococcal meningitis were identified, 63 during the period of routine 7-valent pneumococcal conjugate vaccine immunisation (May 2007-April 2010) and 41 during the period of 13-valent pneumococcal conjugate vaccine immunisation (May 2010-April 2015)...
August 16, 2017: Vaccine
https://www.readbyqxmd.com/read/28689671/detection-of-toxigenic-clostridium-difficile-in-paediatric-patients
#10
Iker Falces-Romero, Paloma Troyano-Hernáez, Silvia García-Bujalance, Fernando Baquero-Artigao, María José Mellado-Peña, Julio García-Rodríguez
INTRODUCTION: Our main objective was a revision of clinical, microbiological and epidemiological results of Clostridium difficile-associated infection in paediatric patients (2010-2015). We compared the diagnoses performed by detection of toxins in feces and those performed by real-time PCR. METHODS: This retrospective study included 82 paediatric patients. Detection of toxigenic C. difficile was performed sequentially, in diarrheal feces and under clinical request...
July 6, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28684093/-osteoarticular-tuberculosis-in-paediatrics-a-review-of-20-years-of-cases-in-a-tertiary-hospital
#11
María José Pérez Durán, Bárbara Moreno Sanz-Gadea, Teresa Del Rosal Raves, María José Mellado Peña, Fernando Baquero-Artigao
No abstract text is available yet for this article.
November 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28479006/-pyomyositis-in-a-non-tropical-area-12-years-of-cased-based-experience
#12
Beatriz González Gómez, Manuel Vargas Pérez, Teresa Del Rosal Rabes, Franciso Javier Aracil Santos, Fernando Baquero-Artigao
No abstract text is available yet for this article.
May 3, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28443682/abandonment-of-dogs-and-cats-public-opinions-as-population-management-indicators
#13
Oswaldo Santos Baquero, Evelyn Nestori Chiozzotto, Rita de Cassia Maria Garcia, Marcos Amaku, Fernando Ferreira
This study involved characterizing public opinions on selected issues related to the abandonment of dogs and cats in Votorantim, São Paulo, Brazil. This goal was achieved by applying multiple correspondence analysis to answers recorded in questionnaires of a population-based survey. The results suggest that the tolerance of potentially problematic behaviors did not depend on the specific kind of behavior, at least among the behaviors evaluated. The opinions given for the most frequent fate of the companion animals did not depend on the species, and those who considered abandonment to be one of the most frequent fates tended to also consider abandonment as a solution to problematic behaviors...
July 2017: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/28363363/dexamethasone-for-parapneumonic-pleural-effusion-a-randomized-double-blind-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Alfredo Tagarro, Enrique Otheo, Fernando Baquero-Artigao, María-Luisa Navarro, Rosa Velasco, Marta Ruiz, María Penín, David Moreno, Pablo Rojo, Rosario Madero
OBJECTIVE: To assess whether dexamethasone (DXM) decreases the time to recovery in patients with parapneumonic pleural effusion. STUDY DESIGN: This was a multicenter, randomized, double blind, parallel-group, placebo-controlled clinical trial of 60 children, ranging in age from 1 month to 14 years, with community-acquired pneumonia (CAP) and pleural effusion. Patients received either intravenous DXM (0.25?mg/kg/dose) or placebo every 6 hours over a period of 48 hours, along with antibiotics...
June 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28360174/complete-genome-sequences-of-isolates-of-enterococcus-faecium-sequence-type-117-a-globally-disseminated-multidrug-resistant-clone
#15
Ana P Tedim, Val F Lanza, Marina Manrique, Eduardo Pareja, Patricia Ruiz-Garbajosa, Rafael Cantón, Fernando Baquero, Teresa M Coque, Raquel Tobes
The emergence of nosocomial infections by multidrug-resistant sequence type 117 (ST117) Enterococcus faecium has been reported in several European countries. ST117 has been detected in Spanish hospitals as one of the main causes of bloodstream infections. We analyzed genome variations of ST117 strains isolated in Madrid and describe the first ST117 closed genome sequences.
March 30, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28284685/identifying-priorities-to-improve-paediatric-in-hospital-antimicrobial-use-by-cross-sectional-evaluation-of-prevalence-and-appropriateness-of-prescription
#16
Walter Alfredo Goycochea-Valdivia, Francisco Moreno-Ramos, José Ramón Paño-Pardo, Francisco Javier Aracil-Santos, Fernando Baquero-Artigao, Teresa Del Rosal-Rabes, María José Mellado-Peña, Luis Escosa-García
INTRODUCTION: Information about paediatric in-hospital antimicrobial usage and prescribing patterns to guide improvement strategies is scant. We aim to use an evaluation of the prevalence and appropriateness of antimicrobial prescription to identify antimicrobial stewardship priorities in children. METHODS: A cross-sectional point study was performed on hospitalised paediatric patients in a Spanish tertiary hospital, assessing the prevalence of antimicrobial prescription (PAP) and appropriateness of antimicrobial prescription (AAP)...
March 8, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28207888/effect-of-the-different-13-valent-pneumococcal-conjugate-vaccination-uptakes-on-the-invasive-pneumococcal-disease-in-children-analysis-of-a-hospital-based-and-population-based-surveillance-study-in-madrid-spain-2007-2015
#17
Juan Picazo, Jesús Ruiz-Contreras, Juan Casado-Flores, Sagrario Negreira, Fernando Baquero, Teresa Hernández-Sampelayo, Enrique Otheo, Cristina Méndez
In the Community of Madrid, the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7-valent (PCV7) in the fully government-funded Regional Immunization Program (RIP) in May, 2010, but was later excluded in May, 2012, and included again in January, 2015. These unique changes allowed us to assess the impact of the different pneumococcal vaccination policies on PCV13 uptake in infants and on the incidence rate (IR) of invasive pneumococcal disease (IPD) in children <15 years old. In this prospective, active, surveillance study, we estimated PCV13 uptakes, IR and incidence rate ratios (IRR) for total IPD and for IPD caused by PCV13- and non-PCV13 serotypes in children <15 years, stratified by age, in four periods with different vaccination policies: fully government-funded PCV7 vaccination, fully government-funded PCV13, mixed public/private funding and only private funding...
2017: PloS One
https://www.readbyqxmd.com/read/28174311/a-numbers-game-ribosome-densities-bacterial-growth-and-antibiotic-mediated-stasis-and-death
#18
Bruce R Levin, Ingrid C McCall, Véronique Perrot, Howard Weiss, Armen Ovesepian, Fernando Baquero
We postulate that the inhibition of growth and low rates of mortality of bacteria exposed to ribosome-binding antibiotics deemed bacteriostatic can be attributed almost uniquely to these drugs reducing the number of ribosomes contributing to protein synthesis, i.e., the number of effective ribosomes. We tested this hypothesis with Escherichia coli K-12 MG1655 and constructs that had been deleted for 1 to 6 of the 7 rRNA (rrn) operons. In the absence of antibiotics, constructs with fewer rrn operons have lower maximum growth rates and longer lag phases than those with more ribosomal operons...
February 7, 2017: MBio
https://www.readbyqxmd.com/read/28167601/imported-dengue-infection-in-a-spanish-hospital-with-a-high-proportion-of-travelers-from-africa-a-9-year-retrospective-study
#19
Carlos Toro, Patricia Trevisi, Beatriz López-Quintana, Aránzazu Amor, Nuria Iglesias, Mercedes Subirats, Concepción Ladrón de Guevara, Mar Lago, Marta Arsuaga, Fernando de la Calle-Prieto, Dolores Herrero, Margarita Rubio, Sabino Puente, Margarita Baquero
AbstractEpidemiological data on dengue in Africa are still scarce. We investigated imported dengue infection among travelers with a high proportion of subjects from Africa over a 9-year period. From January 2005 to December 2013, blood samples from travelers with clinical suspicion of dengue were analyzed. Dengue was diagnosed using serological, antigen detection, and molecular methods. Subjects were classified according to birthplace (Europeans versus non-Europeans) and last country visited. Overall, 10,307 serum samples corresponding to 8,295 patients were studied; 62% were European travelers, most of them from Spain, and 35...
March 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28158709/cytomegalovirus-dna-detection-by-polymerase-chain-reaction-in-cerebrospinal-fluid-of-infants-with-congenital-infection-associations-with-clinical-evaluation-at-birth-and-implications-for-follow-up
#20
Walter-Alfredo Goycochea-Valdivia, Fernando Baquero-Artigao, Teresa Del Rosal, Marie-Antoinette Frick, Pablo Rojo, María-Juncal Echeverría, Antoni Noguera-Julian, Xavier Bringué, Jesús Saavedra-Lozano, Isabel Vives-Oñós, Elisenda Moliner, María-José Cilleruelo, Irene Cuadrado, Elena Colino, Laura Castells, Alfredo Tagarro, Javier Vilas, Pere Soler-Palacin, Daniel Blázquez-Gamero
Background: DNA detection of human cytomegalovirus (hCMV) in cerebrospinal fluid (CSF) by polymerase chain reaction (PCR) is a marker of central nervous system (CNS) involvement in congenital hCMV infection (cCMV), but its prognostic value is unknown. Methods: A multicenter, retrospective study was performed using the Spanish Congenital Cytomegalovirus Infection Database (REDICCMV; http://www.cmvcongenito.es). Newborns with cCMV and a lumbar puncture performed were included and classified according to their hCMV-PCR in CSF result (positive/negative)...
May 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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