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Fernando baquero

Carla Novais, Ana P Tedim, Val F Lanza, Ana R Freitas, Eduarda Silveira, Ricardo Escada, Adam P Roberts, Mohammed Al-Haroni, Fernando Baquero, Luísa Peixe, Teresa M Coque
Ampicillin resistance has greatly contributed to the recent dramatic increase of a cluster of human adapted Enterococcus faecium lineages (ST17, ST18, and ST78) in hospital-based infections. Changes in the chromosomal pbp5 gene have been associated with different levels of ampicillin susceptibility, leading to protein variants (designated as PBP5 C-types to keep the nomenclature used in previous works) with diverse degrees of reduction in penicillin affinity. Our goal was to use a comparative genomics approach to evaluate the relationship between the diversity of PBP5 among E...
2016: Frontiers in Microbiology
Begoña Santiago-García, Daniel Blázquez-Gamero, Fernando Baquero-Artigao, Jesús Ruíz-Contreras, Jose M Bellón, Maria A Muñoz-Fernández, María J Mellado-Peña
BACKGROUND: Children are at higher risk of tuberculosis (TB) dissemination and extrapulmonary disease, contributing greatly to TB-associated morbidity and long-term sequelae. However, there are very few studies that assess the impact and clinical spectrum of pediatric extrapulmonary TB (EPTB) in low-prevalence regions. METHODS: Children <18 years of age diagnosed with TB in Madrid region (2005-2013) were reviewed. We compared the epidemiology, clinical characteristics and the performance of diagnostic tests in childhood extrapulmonary and pulmonary disease...
November 2016: Pediatric Infectious Disease Journal
Val F Lanza, Fernando Baquero, Fernando de la Cruz, Teresa M Coque
MOTIVATION: AccNET (Accessory genome Constellation Network) is a Perl application that aims to compare accessory genomes of a large number of genomic units, both at qualitative and quantitative levels. Using the proteomes extracted from the analysed genomes, AccNET creates a bipartite network compatible with standard network analysis platforms. AccNET allows merging phylogenetic and functional information about the concerned genomes, thus improving the capability of current methods of network analysis...
September 23, 2016: Bioinformatics
Ana R Freitas, Ana P Tedim, Maria V Francia, Lars B Jensen, Carla Novais, Luísa Peixe, Antonio Sánchez-Valenzuela, Arnfinn Sundsfjord, Kristin Hegstad, Guido Werner, Ewa Sadowy, Anette M Hammerum, Lourdes Garcia-Migura, Rob J Willems, Fernando Baquero, Teresa M Coque
OBJECTIVES: Vancomycin-resistant Enterococcus faecium (VREfm) have been increasingly reported since the 1980s. Despite the high number of published studies about VRE epidemiology, the dynamics and evolvability of these microorganisms are still not fully understood. A multilevel population genetic analysis of VREfm outbreak strains since 1986, representing the first comprehensive characterization of plasmid content in E. faecium, was performed to provide a detailed view of potential transmissible units...
August 15, 2016: Journal of Antimicrobial Chemotherapy
Roi Piñeiro Pérez, Begoña Santiago García, Belén Rodríguez Marrodán, Fernando Baquero-Artigao, Cecilia M Fernández-Llamazares, María Goretti López-Ramos, Joan Vinent Genestar, David Gómez-Pastrana Durán, María José Mellado Peña
The Spanish Network for the Study of Paediatric Tuberculosis has shown a lack of national consensus on the treatment of tuberculosis in children, partly due to the unavailability of paediatric presentations of antituberculosis drugs. The harmonisation of tuberculosis treatment in children is a priority in Spain. A joint action is proposed by a group of Spanish experts in childhood tuberculosis and in the area of Paediatric Pharmacology. To this end, a pTBred-led workgroup of members from five scientific bodies has been created...
August 5, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Fernando Baquero-Artigao, Antonio Michavila, Ángeles Suárez-Rodriguez, Anselmo Hernandez, Leticia Martínez-Campos, Cristina Calvo
The suspected allergy to beta-lactam antibiotics, especially penicillin and amoxicillin, is the most frequent reason for consultation in Child Allergy Units. In this consensus document, the clinical and diagnostic criteria of allergic reactions are described, as well as alternative antibiotic treatment for the most common infections diagnosed in paediatrics for patients with known or suspected allergy.
July 14, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Tânia Curiao, Emmanuela Marchi, Denis Grandgirard, Ricardo León-Sampedro, Carlo Viti, Stephen L Leib, Fernando Baquero, Marco R Oggioni, José Luis Martinez, Teresa M Coque
BACKGROUND: Biocides and antibiotics are used to eradicate or prevent the growth of microbial species on surfaces (occasionally on catheters), or infected sites, either in combination or sequentially, raising concerns about the development of co-resistance to both antimicrobial types. The effect of such compounds on Salmonella enterica, a major food-borne and zoonotic pathogen, has been analysed in different studies, but only few works evaluated its biological cost, and the overall effects at the genomic and transcriptomic levels associated with diverse phenotypes resulting from biocide exposure, which was the aim of this work...
2016: BMC Genomics
Begoña Santiago, Daniel Blázquez-Gamero, Fernando Baquero-Artigao, Jesús Ruiz-Contreras, Jose M Bellón, Maria A Muñoz-Fernández, María J Mellado-Peña
BACKGROUND: Children are at higher risk of tuberculosis (TB) dissemination and extrapulmonary disease, contributing greatly to TB associated morbidity and long-term sequelae. However, there are very few studies that assess the impact and clinical spectrum of pediatric extrapulmonary TB (EPTB) in low-prevalence regions. METHODS: Children <18 years of age diagnosed with TB in Madrid region (2005-2013) were reviewed. We compared the epidemiology, clinical characteristics, and the performance of diagnostic tests in childhood extrapulmonary and pulmonary disease...
June 16, 2016: Pediatric Infectious Disease Journal
Ana M Guzman Prieto, Willem van Schaik, Malbert R C Rogers, Teresa M Coque, Fernando Baquero, Jukka Corander, Rob J L Willems
Enterococci are Gram-positive bacteria that are found in plants, soil and as commensals of the gastrointestinal tract of humans, mammals, and insects. Despite their commensal nature, they have also become globally important nosocomial pathogens. Within the genus Enterococcus, Enterococcus faecium, and Enterococcus faecalis are clinically most relevant. In this review, we will discuss how E. faecium and E. faecalis have evolved to become a globally disseminated nosocomial pathogen. E. faecium has a defined sub-population that is associated with hospitalized patients and is rarely encountered in community settings...
2016: Frontiers in Microbiology
Fernando C I Marcucci, Marcos A S Cabrera, Anamaria Baquero Perilla, Marilia Maroneze Brun, Eder Marcos L de Barros, Vanessa M Martins, John P Rosenberg, Patsy Yates
BACKGROUND: The Brazilian healthcare system offers universal coverage but lacks information about how patients with PC needs are serviced by its primary care program, Estratégia Saúde da Família (ESF). METHODS: Cross-sectional study in community settings. Patients in ESF program were screened using a Palliative Care Screening Tool (PCST). Included patients were assessed with Karnofsky Performance Scale (KPS), Edmonton Symptom Assessment System (ESAS) and Palliative Care Outcome Scale (POS)...
2016: BMC Palliative Care
Elina Numminen, Michael Gutmann, Mikhail Shubin, Pekka Marttinen, Guillaume Méric, Willem van Schaik, Teresa M Coque, Fernando Baquero, Rob J L Willems, Samuel K Sheppard, Edward J Feil, William P Hanage, Jukka Corander
Many key bacterial pathogens are frequently carried asymptomatically, and the emergence and spread of these opportunistic pathogens can be driven, or mitigated, via demographic changes within the host population. These inter-host transmission dynamics combine with basic evolutionary parameters such as rates of mutation and recombination, population size and selection, to shape the genetic diversity within bacterial populations. Whilst many studies have focused on how molecular processes underpin bacterial population structure, the impact of host migration and the connectivity of the local populations has received far less attention...
May 7, 2016: Journal of Theoretical Biology
Ricardo León-Sampedro, Carla Novais, Luísa Peixe, Fernando Baquero, Teresa M Coque
This work describes the diversity and evolution of Tn5801 among enterococci, staphylococci, and streptococci based on analysis of the 5,073 genomes of these bacterial groups available in gene databases. We also examined 610 isolates of Enterococcus (from 10 countries, 1987 to 2010) for the presence of this and other known CTn-tet(M) elements due to the scarcity of data about Tn5801 among enterococci. Genome location (by ICeu-I-pulsed-field gel electrophoresis [PFGE] hybridization/integration site identification), conjugation and fitness (by standard methods), Tn5801 characterization (by long-PCR mapping/sequencing), and clonality (by PFGE/multilocus sequence typing [MLST]) were studied...
March 2016: Antimicrobial Agents and Chemotherapy
Oriol Dols-Icardo, Oriol Iborra, Jessica Valdivia, Pau Pastor, Agustín Ruiz, Adolfo López de Munain, Raquel Sánchez-Valle, Victoria Álvarez, Pascual Sánchez-Juan, Alberto Lleó, Juan Fortea, Rafael Blesa, Fernando Cardona, Miquel Baquero, María Dolores Alonso, Sara Ortega-Cubero, María A Pastor, Cristina Razquin, Mercè Boada, Isabel Hernández, Ana Gorostidi, Fermín Moreno, Miren Zulaika, Albert Lladó, Eliecer Coto, Onofre Combarros, Jordi Pérez-Tur, Jordi Clarimón
The tubulin alpha 4a (TUBA4A) gene has been recently associated with amyotrophic lateral sclerosis. Interestingly, some of the mutation carriers were also diagnosed with frontotemporal degeneration (FTD) or mild cognitive impairment. With the aim to investigate the role of TUBA4A in FTD, we screened TUBA4A in a series of 814 FTD patients from Spain. Our data did not disclose any nonsense or missense variant in the cohort, thus suggesting that TUBA4A mutations are not associated with FTD.
February 2016: Neurobiology of Aging
Jason Onell Ardila Galvis, Oswaldo Santos Baquero, Ricardo Augusto Dias, Fernando Ferreira, Evelyn Nestori Chiozzotto, José Henrique Hildebrand Grisi-Filho
The continuous improvement of the information systems of organizations that work toward the control of stray dog and cat populations facilitates the implementation of programs aimed at reducing the number of animals that roam free in public streets. This study aimed to present techniques to improve the understanding of the spatial distribution of stray dogs and cats and of people who adopt these animals and the fate of these animals in zoonosis control centers (ZCC). Ripley's K function was used with a Euclidean distance graph to detect the distribution pattern of dogs and cats captured and of the people who adopted these animals...
2015: Geospatial Health
Ana Méndez-Echevarría, Talia Sainz, Milagros García-Hortelano, Fernando Baquero-Artigao, Maria J Mellado
No abstract text is available yet for this article.
October 2015: Pediatric Infectious Disease Journal
Marcelino Campos, Carlos Llorens, José M Sempere, Ricardo Futami, Irene Rodriguez, Purificación Carrasco, Rafael Capilla, Amparo Latorre, Teresa M Coque, Andres Moya, Fernando Baquero
BACKGROUND: Antibiotic resistance is a major biomedical problem upon which public health systems demand solutions to construe the dynamics and epidemiological risk of resistant bacteria in anthropogenically-altered environments. The implementation of computable models with reciprocity within and between levels of biological organization (i.e. essential nesting) is central for studying antibiotic resistances. Antibiotic resistance is not just the result of antibiotic-driven selection but more properly the consequence of a complex hierarchy of processes shaping the ecology and evolution of the distinct subcellular, cellular and supra-cellular vehicles involved in the dissemination of resistance genes...
2015: Biology Direct
Val Fernández Lanza, Ana P Tedim, José Luís Martínez, Fernando Baquero, Teresa M Coque
The phylum Firmicutes is one of the most abundant groups of prokaryotes in the microbiota of humans and animals and includes genera of outstanding relevance in biomedicine, health care, and industry. Antimicrobial drug resistance is now considered a global health security challenge of the 21st century, and this heterogeneous group of microorganisms represents a significant part of this public health issue.The presence of the same resistant genes in unrelated bacterial genera indicates a complex history of genetic interactions...
April 2015: Microbiology Spectrum
Ana Isabel Blanco-Sánchez, Ana Méndez-Echevarría, Paula Alonso-Quintela, Adela García-Perea, Fernando Baquero-Artigao
No abstract text is available yet for this article.
June 4, 2015: Enfermedades Infecciosas y Microbiología Clínica
Teresa Del Rosal Rabes, Fernando Baquero-Artigao, Ana María Méndez-Echevarría, María José Mellado Peña
A review was conducted on infants less than 3 months of age diagnosed with tuberculosis between 1978 and 2014. Eight patients were diagnosed (1.4% of paediatric tuberculosis cases): 3 confirmed congenital tuberculosis, 3 suspected (endometrial biopsy was not performed), and 2 postnatal tuberculosis. Tuberculin skin test was negative in two patients. Diagnostic performance of culture (7/7, 100%) and PCR (3/3, 100%) of gastric aspirates was higher than that of acid-fast bacilli smears (5/8, 62%) and IGRA test (1/3, 33%)...
April 29, 2015: Enfermedades Infecciosas y Microbiología Clínica
José L Martínez, Teresa M Coque, Fernando Baquero
No abstract text is available yet for this article.
June 2015: Nature Reviews. Microbiology
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