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Fernando baquero

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https://www.readbyqxmd.com/read/28479006/-pyomyositis-in-a-non-tropical-area-12-years-of-cased-based-experience
#1
Beatriz González Gómez, Manuel Vargas Pérez, Teresa Del Rosal Rabes, Franciso Javier Aracil Santos, Fernando Baquero-Artigao
No abstract text is available yet for this article.
May 3, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28443682/abandonment-of-dogs-and-cats-public-opinions-as-population-management-indicators
#2
Oswaldo Santos Baquero, Evelyn Nestori Chiozzotto, Rita de Cassia Maria Garcia, Marcos Amaku, Fernando Ferreira
This study involved characterizing public opinions on selected issues related to the abandonment of dogs and cats in Votorantim, São Paulo, Brazil. This goal was achieved by applying multiple correspondence analysis to answers recorded in questionnaires of a population-based survey. The results suggest that the tolerance of potentially problematic behaviors did not depend on the specific kind of behavior, at least among the behaviors evaluated. The opinions given for the most frequent fate of the companion animals did not depend on the species, and those who considered abandonment to be one of the most frequent fates tended to also consider abandonment as a solution to problematic behaviors...
July 2017: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/28363363/dexamethasone-for-parapneumonic-pleural-effusion-a-randomized-double-blind-clinical-trial
#3
Alfredo Tagarro, Enrique Otheo, Fernando Baquero-Artigao, María-Luisa Navarro, Rosa Velasco, Marta Ruiz, María Penín, David Moreno, Pablo Rojo, Rosario Madero
OBJECTIVE: To assess whether dexamethasone (DXM) decreases the time to recovery in patients with parapneumonic pleural effusion. STUDY DESIGN: This was a multicenter, randomized, double blind, parallel-group, placebo-controlled clinical trial of 60 children, ranging in age from 1 month to 14 years, with community-acquired pneumonia (CAP) and pleural effusion. Patients received either intravenous DXM (0.25 mg/kg/dose) or placebo every 6 hours over a period of 48 hours, along with antibiotics...
March 28, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28360174/complete-genome-sequences-of-isolates-of-enterococcus-faecium-sequence-type-117-a-globally-disseminated-multidrug-resistant-clone
#4
Ana P Tedim, Val F Lanza, Marina Manrique, Eduardo Pareja, Patricia Ruiz-Garbajosa, Rafael Cantón, Fernando Baquero, Teresa M Coque, Raquel Tobes
The emergence of nosocomial infections by multidrug-resistant sequence type 117 (ST117) Enterococcus faecium has been reported in several European countries. ST117 has been detected in Spanish hospitals as one of the main causes of bloodstream infections. We analyzed genome variations of ST117 strains isolated in Madrid and describe the first ST117 closed genome sequences.
March 30, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28284685/identifying-priorities-to-improve-paediatric-in-hospital-antimicrobial-use-by-cross-sectional-evaluation-of-prevalence-and-appropriateness-of-prescription
#5
Walter Alfredo Goycochea-Valdivia, Francisco Moreno-Ramos, José Ramón Paño-Pardo, Francisco Javier Aracil-Santos, Fernando Baquero-Artigao, Teresa Del Rosal-Rabes, María José Mellado-Peña, Luis Escosa-García
INTRODUCTION: Information about paediatric in-hospital antimicrobial usage and prescribing patterns to guide improvement strategies is scant. We aim to use an evaluation of the prevalence and appropriateness of antimicrobial prescription to identify antimicrobial stewardship priorities in children. METHODS: A cross-sectional point study was performed on hospitalised paediatric patients in a Spanish tertiary hospital, assessing the prevalence of antimicrobial prescription (PAP) and appropriateness of antimicrobial prescription (AAP)...
March 8, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28207888/effect-of-the-different-13-valent-pneumococcal-conjugate-vaccination-uptakes-on-the-invasive-pneumococcal-disease-in-children-analysis-of-a-hospital-based-and-population-based-surveillance-study-in-madrid-spain-2007-2015
#6
Juan Picazo, Jesús Ruiz-Contreras, Juan Casado-Flores, Sagrario Negreira, Fernando Baquero, Teresa Hernández-Sampelayo, Enrique Otheo, Cristina Méndez
In the Community of Madrid, the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7-valent (PCV7) in the fully government-funded Regional Immunization Program (RIP) in May, 2010, but was later excluded in May, 2012, and included again in January, 2015. These unique changes allowed us to assess the impact of the different pneumococcal vaccination policies on PCV13 uptake in infants and on the incidence rate (IR) of invasive pneumococcal disease (IPD) in children <15 years old. In this prospective, active, surveillance study, we estimated PCV13 uptakes, IR and incidence rate ratios (IRR) for total IPD and for IPD caused by PCV13- and non-PCV13 serotypes in children <15 years, stratified by age, in four periods with different vaccination policies: fully government-funded PCV7 vaccination, fully government-funded PCV13, mixed public/private funding and only private funding...
2017: PloS One
https://www.readbyqxmd.com/read/28174311/a-numbers-game-ribosome-densities-bacterial-growth-and-antibiotic-mediated-stasis-and-death
#7
Bruce R Levin, Ingrid C McCall, Véronique Perrot, Howard Weiss, Armen Ovesepian, Fernando Baquero
We postulate that the inhibition of growth and low rates of mortality of bacteria exposed to ribosome-binding antibiotics deemed bacteriostatic can be attributed almost uniquely to these drugs reducing the number of ribosomes contributing to protein synthesis, i.e., the number of effective ribosomes. We tested this hypothesis with Escherichia coli K-12 MG1655 and constructs that had been deleted for 1 to 6 of the 7 rRNA (rrn) operons. In the absence of antibiotics, constructs with fewer rrn operons have lower maximum growth rates and longer lag phases than those with more ribosomal operons...
February 7, 2017: MBio
https://www.readbyqxmd.com/read/28167601/imported-dengue-infection-in-a-spanish-hospital-with-a-high-proportion-of-travelers-from-africa-a-9-year-retrospective-study
#8
Carlos Toro, Patricia Trevisi, Beatriz López-Quintana, Aránzazu Amor, Nuria Iglesias, Mercedes Subirats, Concepción Ladrón de Guevara, Mar Lago, Marta Arsuaga, Fernando de la Calle-Prieto, Dolores Herrero, Margarita Rubio, Sabino Puente, Margarita Baquero
AbstractEpidemiological data on dengue in Africa are still scarce. We investigated imported dengue infection among travelers with a high proportion of subjects from Africa over a 9-year period. From January 2005 to December 2013, blood samples from travelers with clinical suspicion of dengue were analyzed. Dengue was diagnosed using serological, antigen detection, and molecular methods. Subjects were classified according to birthplace (Europeans versus non-Europeans) and last country visited. Overall, 10,307 serum samples corresponding to 8,295 patients were studied; 62% were European travelers, most of them from Spain, and 35...
March 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28158709/cytomegalovirus-dna-detection-by-polymerase-chain-reaction-in-cerebrospinal-fluid-of-infants-with-congenital-infection-associations-with-clinical-evaluation-at-birth-and-implications-for-follow-up
#9
Walter-Alfredo Goycochea-Valdivia, Fernando Baquero-Artigao, Teresa Del Rosal, Marie-Antoinette Frick, Pablo Rojo, María-Juncal Echeverría, Antoni Noguera-Julian, Xavier Bringué, Jesús Saavedra-Lozano, Isabel Vives-Oñós, Elisenda Moliner, María-José Cilleruelo, Irene Cuadrado, Elena Colino, Laura Castells, Alfredo Tagarro, Javier Vilas, Pere Soler-Palacin, Daniel Blázquez-Gamero
Background: DNA detection of human cytomegalovirus (hCMV) in cerebrospinal fluid (CSF) by polymerase chain reaction (PCR) is a marker of central nervous system (CNS) involvement in congenital hCMV infection (cCMV), but its prognostic value is unknown. Methods: A multicenter, retrospective study was performed using the Spanish Congenital Cytomegalovirus Infection Database (REDICCMV; http://www.cmvcongenito.es). Newborns with cCMV and a lumbar puncture performed were included and classified according to their hCMV-PCR in CSF result (positive/negative)...
May 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28098134/-validity-reliability-and-associated-factors-of-the-international-physical-activity-questionnaire-adapted-to-elderly-ipaq-e
#10
Francisco Javier Rubio Castañeda, Concepción Tomás Aznar, Carmen Muro Baquero
OBJECTIVE: Physical activity contributes to improve health and reduce mortality in older people. The objective was to analyze the validity of content and reliability of the short version of IPAQ-E in elderly people who attended to Fernando el Católico health center between May 2013 and March 2015. METHODS: Validation study of the short version of the international physical activity questionnaire (IPAQ) adapted in Spanish elderly (IPAQ-E). Our sampling was for convenience...
January 18, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/27861983/genomic-and-metagenomic-technologies-to-explore-the-antibiotic-resistance-mobilome
#11
José L Martínez, Teresa M Coque, Val F Lanza, Fernando de la Cruz, Fernando Baquero
Antibiotic resistance is a relevant problem for human health that requires global approaches to establish a deep understanding of the processes of acquisition, stabilization, and spread of resistance among human bacterial pathogens. Since natural (nonclinical) ecosystems are reservoirs of resistance genes, a health-integrated study of the epidemiology of antibiotic resistance requires the exploration of such ecosystems with the aim of determining the role they may play in the selection, evolution, and spread of antibiotic resistance genes, involving the so-called resistance mobilome...
November 10, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27833059/enterovirus-neurological-disease-and-bacterial-coinfection-in-very-young-infants-with-fever
#12
Cristina Calvo, Paula Gallardo, Patricia Torija, Sara Bellón, Ana Méndez-Echeverría, Teresa Del Rosal, Fernando Baquero-Artigao, Talía Sainz, María Romero, María Cabrerizo
BACKGROUND: Very little information exists on simultaneous infections by viruses and bacteria in infants with fever without source (FWS). OBJECTIVES: To investigate the incidence of bacterial coinfection in infants up to 3 months of age with neurological viral infection. STUDY DESIGN: Prospective study performed in infants below 90 days of age attending the emergency room of two public hospitals in Spain for FWS. Those who had viral screening performed in CSF, together with blood, CSF and urine cultures were included...
December 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27766095/co-diversification-of-enterococcus-faecium-core-genomes-and-pbp5-evidences-of-pbp5-horizontal-transfer
#13
Carla Novais, Ana P Tedim, Val F Lanza, Ana R Freitas, Eduarda Silveira, Ricardo Escada, Adam P Roberts, Mohammed Al-Haroni, Fernando Baquero, Luísa Peixe, Teresa M Coque
Ampicillin resistance has greatly contributed to the recent dramatic increase of a cluster of human adapted Enterococcus faecium lineages (ST17, ST18, and ST78) in hospital-based infections. Changes in the chromosomal pbp5 gene have been associated with different levels of ampicillin susceptibility, leading to protein variants (designated as PBP5 C-types to keep the nomenclature used in previous works) with diverse degrees of reduction in penicillin affinity. Our goal was to use a comparative genomics approach to evaluate the relationship between the diversity of PBP5 among E...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27753763/pediatric-extrapulmonary-tuberculosis-clinical-spectrum-risk-factors-and-diagnostic-challenges-in-a-low-prevalence-region
#14
Begoña Santiago-García, Daniel Blázquez-Gamero, Fernando Baquero-Artigao, Jesús Ruíz-Contreras, Jose M Bellón, Maria A Muñoz-Fernández, María J Mellado-Peña
BACKGROUND: Children are at higher risk of tuberculosis (TB) dissemination and extrapulmonary disease, contributing greatly to TB-associated morbidity and long-term sequelae. However, there are very few studies that assess the impact and clinical spectrum of pediatric extrapulmonary TB (EPTB) in low-prevalence regions. METHODS: Children <18 years of age diagnosed with TB in Madrid region (2005-2013) were reviewed. We compared the epidemiology, clinical characteristics and the performance of diagnostic tests in childhood extrapulmonary and pulmonary disease...
November 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27663497/accnet-accessory-genome-constellation-network-comparative-genomics-software-for-accessory-genome-analysis-using-bipartite-networks
#15
Val F Lanza, Fernando Baquero, Fernando de la Cruz, Teresa M Coque
MOTIVATION: AccNET (Accessory genome Constellation Network) is a Perl application that aims to compare accessory genomes of a large number of genomic units, both at qualitative and quantitative levels. Using the proteomes extracted from the analysed genomes, AccNET creates a bipartite network compatible with standard network analysis platforms. AccNET allows merging phylogenetic and functional information about the concerned genomes, thus improving the capability of current methods of network analysis...
September 23, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27530756/multilevel-population-genetic-analysis-of-vana-and-vanb-enterococcus-faecium-causing-nosocomial-outbreaks-in-27-countries-1986-2012
#16
Ana R Freitas, Ana P Tedim, Maria V Francia, Lars B Jensen, Carla Novais, Luísa Peixe, Antonio Sánchez-Valenzuela, Arnfinn Sundsfjord, Kristin Hegstad, Guido Werner, Ewa Sadowy, Anette M Hammerum, Lourdes Garcia-Migura, Rob J Willems, Fernando Baquero, Teresa M Coque
OBJECTIVES: Vancomycin-resistant Enterococcus faecium (VREfm) have been increasingly reported since the 1980s. Despite the high number of published studies about VRE epidemiology, the dynamics and evolvability of these microorganisms are still not fully understood. A multilevel population genetic analysis of VREfm outbreak strains since 1986, representing the first comprehensive characterization of plasmid content in E. faecium, was performed to provide a detailed view of potential transmissible units...
December 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27503786/-recommendations-for-the-preparation-and-administration-of-antituberculosis-drugs-in-children-second-phase-of-the-magistral-project-of-the-spanish-network-for-the-study-of-paediatric-tuberculosis-ptbred
#17
Roi Piñeiro Pérez, Begoña Santiago García, Belén Rodríguez Marrodán, Fernando Baquero-Artigao, Cecilia M Fernández-Llamazares, María Goretti López-Ramos, Joan Vinent Genestar, David Gómez-Pastrana Durán, María José Mellado Peña
The Spanish Network for the Study of Paediatric Tuberculosis has shown a lack of national consensus on the treatment of tuberculosis in children, partly due to the unavailability of paediatric presentations of antituberculosis drugs. The harmonisation of tuberculosis treatment in children is a priority in Spain. A joint action is proposed by a group of Spanish experts in childhood tuberculosis and in the area of Paediatric Pharmacology. To this end, a pTBred-led workgroup of members from five scientific bodies has been created...
December 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27427544/-spanish-society-of-pediatric-infectious-diseases-spanish-society-of-paediatric-clinical-immunology-and-allergy-spanish-association-of-paediatric-primary-care-and-the-spanish-society-of-extra-hospital-paediatrics-and-primary-health-care-consensus-document-on
#18
Fernando Baquero-Artigao, Antonio Michavila, Ángeles Suárez-Rodriguez, Anselmo Hernandez, Leticia Martínez-Campos, Cristina Calvo
The suspected allergy to beta-lactam antibiotics, especially penicillin and amoxicillin, is the most frequent reason for consultation in Child Allergy Units. In this consensus document, the clinical and diagnostic criteria of allergic reactions are described, as well as alternative antibiotic treatment for the most common infections diagnosed in paediatrics for patients with known or suspected allergy.
February 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27411385/multiple-adaptive-routes-of-salmonella-enterica-typhimurium-to-biocide-and-antibiotic-exposure
#19
Tânia Curiao, Emmanuela Marchi, Denis Grandgirard, Ricardo León-Sampedro, Carlo Viti, Stephen L Leib, Fernando Baquero, Marco R Oggioni, José Luis Martinez, Teresa M Coque
BACKGROUND: Biocides and antibiotics are used to eradicate or prevent the growth of microbial species on surfaces (occasionally on catheters), or infected sites, either in combination or sequentially, raising concerns about the development of co-resistance to both antimicrobial types. The effect of such compounds on Salmonella enterica, a major food-borne and zoonotic pathogen, has been analysed in different studies, but only few works evaluated its biological cost, and the overall effects at the genomic and transcriptomic levels associated with diverse phenotypes resulting from biocide exposure, which was the aim of this work...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27314822/pediatric-extrapulmonary-tuberculosis-clinical-spectrum-risk-factors-and-diagnostic-challenges-in-a-low-prevalence-region
#20
Begoña Santiago, Daniel Blázquez-Gamero, Fernando Baquero-Artigao, Jesús Ruiz-Contreras, Jose M Bellón, Maria A Muñoz-Fernández, María J Mellado-Peña
BACKGROUND: Children are at higher risk of tuberculosis (TB) dissemination and extrapulmonary disease, contributing greatly to TB associated morbidity and long-term sequelae. However, there are very few studies that assess the impact and clinical spectrum of pediatric extrapulmonary TB (EPTB) in low-prevalence regions. METHODS: Children <18 years of age diagnosed with TB in Madrid region (2005-2013) were reviewed. We compared the epidemiology, clinical characteristics, and the performance of diagnostic tests in childhood extrapulmonary and pulmonary disease...
June 16, 2016: Pediatric Infectious Disease Journal
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