keyword
https://read.qxmd.com/read/38650114/a-spontaneous-hyperglycaemic-cynomolgus-monkey-presents-cognitive-deficits-neurological-dysfunction-and-cataract
#21
JOURNAL ARTICLE
Hongdi Huang, Jianglin Pu, Yufang Zhou, Yang Fan, Yali Zhang, Yanling Li, Yangzhuo Chen, Yun Wang, Xiaomei Yu, Bulgin Dmitry, Zhu Zhou, Jianhong Wang
Chronic hyperglycaemia is a chief feature of diabetes mellitus and complicates with many systematic anomalies. Non-human primates (NHPs) are excellent for studying hyperglycaemia or diabetes and associated comorbidities, but lack behavioural observation. In the study, behavioural, brain imaging and histological analysis were performed in a case of spontaneously hyperglycaemic (HGM) Macaca fascicularis. The results were shown that the HGM monkey had persistent body weight loss, long-term hyperglycaemia, insulin resistance, dyslipidemia, but normal concentrations of insulin, C-peptide, insulin autoantibody, islet cell antibody and glutamic acid decarboxylase antibody...
June 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38649956/associations-between-glucocorticoids-and-habitat-selection-reflect-daily-and-seasonal-energy-requirements
#22
JOURNAL ARTICLE
Levi Newediuk, Gabriela F Mastromonaco, Eric Vander Wal
BACKGROUND: Glucocorticoids are often associated with stressful environments, but they are also thought to drive the best strategies to improve fitness in stressful environments. Glucocorticoids improve fitness in part by regulating foraging behaviours in response to daily and seasonal energy requirements. However, many studies demonstrating relationships between foraging behaviour and glucocorticoids are experimental, and few observational studies conducted under natural conditions have tested whether changing glucocorticoid levels are related to daily and seasonal changes in energy requirements...
April 22, 2024: Movement Ecology
https://read.qxmd.com/read/38649443/isolation-and-characterisation-of-a-novel-silviavirus-bacteriophage-promising-antimicrobial-agent-against-methicillin-resistant-staphylococcus-aureus-infections
#23
JOURNAL ARTICLE
Varintip Lerdsittikul, Sukanya Apiratwarrasakul, Thassanant Atithep, Patoo Withatanung, Nitaya Indrawattana, Pornpan Pumirat, Somjit Chaiwattanarungruengpaisan, Metawee Thongdee
The increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) emphasises the urgent need for novel antimicrobial agents as alternatives to antibiotics. Bacteriophage therapy is one of the most promising antimicrobial strategies. Here, we isolated and comprehensively characterized a novel Staphylococcus phage, vB_SauM_VL10 (VL10), from urban sewage. The VL10 genome displays 141,746 bp of linear double-stranded DNA, containing 193 open reading frames and lacking tRNA, virulence, or antibiotic resistance genes...
April 22, 2024: Scientific Reports
https://read.qxmd.com/read/38649388/predictors-of-pathological-gambling-behaviours-in-parents-population-in-nigeria
#24
JOURNAL ARTICLE
Moses Onyemaechi Ede, Kingsley Chinaza Nwosu, Chinedu Ifedi Okeke, Joy Obiageli Oneli
The increasing incidence of psychological pains, burnout, and anxiety among gamblers in Nigeria is high. This is because pathological gambling (PG) is on the rise and it is linked to many social vices such as stealing, drug abuse, and sexual abuse. It is important to investigate the trajectories of PG in Nigeria. A cross-sectional survey design was employed in our study with 197 participants sampled from 28 gambling venues in Nigeria made up the study's sample size. Of the 197, 131 (66.5%) were males and 66 (33...
April 22, 2024: Scientific Reports
https://read.qxmd.com/read/38648990/automatic-classification-of-dog-barking-using-deep-learning
#25
JOURNAL ARTICLE
José Ramón Gómez-Armenta, Humberto Pérez-Espinosa, José Alberto Fernández-Zepeda, Verónica Reyes-Meza
Barking and other dog vocalizations have acoustic properties related to emotions, physiological reactions, attitudes, or some particular internal states. In the field of intelligent audio analysis, researchers use methods based on signal processing and machine learning to analyze the digitized acoustic signals' properties and obtain relevant information. The present work describes a method to classify the identity, breed, age, sex, and context associated with each bark. This information can support the decisions of people who regularly interact with animals, such as dog trainers, veterinarians, rescuers, police, people with visual impairment...
April 20, 2024: Behavioural Processes
https://read.qxmd.com/read/38648665/workplace-sexual-harassment-a-qualitative-study-of-the-self-labelling-process-among-employees-in-denmark
#26
JOURNAL ARTICLE
Maj Britt Dahl Nielsen, Sofie Smedegaard Skov, Gry Grundtvig, Anna Paldam Folker, Reiner Rugulies, Per Tybjerg Aldrich, Thomas Clausen, Ida E H Madsen
PURPOSE: To explore how employees understand work-related sexual harassment and label their experience. METHODS: This study is based on 13 semi-structured in-depth interviews with employees exposed to workplace sexual harassment. We analysed the data using a thematic approach drawing on frameworks of sensemaking in organizations. RESULTS: We identified four major themes. The first two themes, distinguishing between sexual harassment and unwanted sexual attention and labelling real life sexual harassment , outline the interviewees' definitions of the two terms "sexual harassment" and "unwanted sexual harassment" and reveal the challenges of labelling sexually harassing behaviours at work...
December 2024: International Journal of Qualitative Studies on Health and Well-being
https://read.qxmd.com/read/38648499/what-guides-student-learning-in-the-clinical-years-a-mixed-methods-study-exploring-study-behaviours-prior-to-the-uk-medical-licensing-assessment-ukmla
#27
JOURNAL ARTICLE
Shehla Baig, Roaa Al-Bedaery, Connor Togher, Jonathan P W De Oliveira, Naireen Asim
PURPOSE: Student study behaviours that prioritise the UKMLA content map over the local curriculum are a significant risk for UK medical education. To mitigate this, we describe a student-centred faculty process to improve local curriculum guidance based on an evaluation of student study behaviours, concerns and needs. Responses informed the build of an online curriculum map. METHODS: A mixed methods approach was adopted, including an online anonymous survey exploring student study behaviours and preferences for curricular guidance...
April 22, 2024: Medical Teacher
https://read.qxmd.com/read/38648410/repellent-and-larvicidal-properties-of-selected-indigenous-plants-in-the-control-of-anopheles-mosquitoes
#28
JOURNAL ARTICLE
Obadiah Opoku-Bamfoh, Sandra Abankwa Kwarteng, Frema A N Owusu, Raphael Akpanya, Kelvin A Mensah, Mercy Badu, Fred Y Gyamfi, Victoria Sogbo, Ebenezer J D Belford, Abena Boakye, Henry Morgan Morrison, Patrick K Obuam, Sylvester Coleman
BACKGROUND OBJECTIVES: Widespread pyrethroid resistance and plastic-feeding behaviour of most malaria vectors across Africa threaten the efficacy of current insecticide-based vector control interventions like Insecticide-Treated Nets (ITNs) and Indoor Residual Spraying (IRS). This study examined the larvicidal activity ofMorinda citrifolia against Anopheles gambiae larvae and the repellent properties of Morinda citrifolia (Noni), Moringa oleifera (Moringa), and Ocimum basilicum (Basil) as complementary vector control tools against Anopheles gambiae sensu lato (s...
January 1, 2024: Journal of Vector Borne Diseases
https://read.qxmd.com/read/38645967/parental-factors-predicting-social-deviance-and-psychological-outcomes-in-offspring-evidence-from-the-avon-longitudinal-study-of-parents-and-children-alspac
#29
JOURNAL ARTICLE
Lloyd Balbuena, Mansfield Mela, A G Ahmed
Objective: The objective of the present study was to examine whether exposure to prenatal psychoactive substances is associated with psychological outcomes and deviant behaviour. Methods: This was a secondary analysis of 7,769 mother-child dyads in the Avon Longitudinal Study of Parents and Children (ALSPAC) who were followed until the children were aged approximately 12 years. Parental characteristics and maternal use of various substances were collected in pregnancy and entered as predictors of psychological outcomes in childhood and deviant behaviours in early adolescence...
April 2024: Nordisk Alkohol- & Narkotikatidskrift: NAT
https://read.qxmd.com/read/38645565/microenvironment-systemic-inflammatory-response-and-tumor-markers-considering-consensus-molecular-subtypes-of-colorectal-cancer
#30
JOURNAL ARTICLE
Anna Jakab, Árpád V Patai, Mónika Darvas, Karolina Tormássi-Bély, Tamás Micsik
Introduction: Colorectal carcinomas (CRC) are one of the most frequent malignancies worldwide. Based on gene expression profile analysis, CRCs can be classified into four distinct subtypes also known as the consensus molecular subtypes (CMS), which predict biological behaviour. Besides CMS, several other aspects of tumor microenvironment (TME) and systemic inflammatory response (SIR) influence the outcome of CRC patients. TME and inflammation have important role in the immune (CMS1) and mesenchymal (CMS4) subtypes, however, the relationship between these and systemic inflammation has not been assessed yet...
2024: Pathology Oncology Research: POR
https://read.qxmd.com/read/38645380/virtual-reality-based-cognitive-behavioural-therapy-for-the-treatment-of-anxiety-in-patients-with-acute-myocardial-infarction-a-randomised-clinical-trial
#31
JOURNAL ARTICLE
Yuan Yuan Li, Juan Peng, Yuan Yang Ping, Weng Jia Jun, Yan'e Lu, Jia Jia Liu, Shi Kun Xu, Li Hua Guan, Dong Huang, Qi Bing Wang, Ju Ying Qian, Ze Xin Zhao, Ya Bin Wei, Jun Bo Ge, Xiao Huang
BACKGROUND: The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction (AMI), significantly disrupting their recovery. Providing timely and easily accessible psychological interventions using virtual reality-based cognitive-behavioural therapy (VR-CBT) could potentially improve both acute and long-term symptoms affecting their mental health. AIMS: We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit (ICU) during the acute stage of their illness...
2024: General Psychiatry
https://read.qxmd.com/read/38645303/the-effectiveness-of-abstinence-based-and-harm-reduction-based-interventions-in-reducing-problematic-substance-use-in-adults-who-are-experiencing-homelessness-in-high-income-countries-a-systematic-review-and-meta-analysis-a-systematic-review
#32
REVIEW
Chris O'Leary, Rob Ralphs, Jennifer Stevenson, Andrew Smith, Jordan Harrison, Zsolt Kiss, Harry Armitage
BACKGROUND: Homelessness is a traumatic experience, and can have a devastating effect on those experiencing it. People who are homeless often face significant barriers when accessing public services, and have often experienced adverse childhood events, extreme social disadvantage, physical, emotional and sexual abuse, neglect, low self-esteem, poor physical and mental health, and much lower life expectancy compared to the general population. Rates of problematic substance use are disproportionately high, with many using drugs and alcohol to deal with the stress of living on the street, to keep warm, or to block out memories of previous abuse or trauma...
June 2024: Campbell Syst Rev
https://read.qxmd.com/read/38644879/internet-addiction-of-university-students-in-the-covid-19-process
#33
JOURNAL ARTICLE
İsmail Şan, Hanife Gülhan Orhan Karsak, Eyüp İzci, Kübra Öncül
This study delves into the intricate dynamics of internet addiction among university students, leveraging a comprehensive quantitative approach to unravel the myriad factors influencing this modern-day malaise. Utilizing logistic regression analysis, this research delineates the predictive significance of Daily Internet Usage Time (DIUT) and Communicative Internet Use Frequency (CIUF) on the propensity for internet addiction, with the analysis substantiating these variables as potent predictors. The model elucidates a significant variance in internet addiction, affirming the complexity of internet addiction as influenced by a constellation of behavioral patterns...
April 30, 2024: Heliyon
https://read.qxmd.com/read/38644744/the-impact-of-a-hospital-based-special-care-unit-on-behavioural-and-psychological-symptoms-in-older-people-living-with-dementia
#34
JOURNAL ARTICLE
Frederick A Graham, Lisa Kelly, Elizabeth A Burmeister, Amanda Henderson, Annette Broome, Ruth E Hubbard, Emily H Gordon
BACKGROUND: Hospital patients with behavioural and psychological symptoms of dementia (BPSD) are vulnerable to a range of adverse outcomes. Hospital-based Special Care Units (SCUs) are secure dementia-enabling environments providing specialised gerontological care. Due to a scarcity of research, their value remains unconfirmed. OBJECTIVE: To compare hospital based SCU management of BPSD with standard care. DESIGN: Single-case multiple baseline design...
April 1, 2024: Age and Ageing
https://read.qxmd.com/read/38644526/impact-of-income-and-financial-subsidies-on-oral-health-care-utilization-among-persons-with-disabilities-in-singapore
#35
JOURNAL ARTICLE
Sharon Hui Xuan Tan, Gabriel Keng Yan Lee, Charlene Enhui Goh, Huei Jinn Tong, Janice Cheah Ping Chuang, Kok-Yang Ang, David Guang Xu Lim, Xiaoli Gao
BACKGROUND/AIM(S): Globally, studies have shown that the dental disease burden among persons with intellectual and/or developmental disabilities (IDD) is high and can be attributed to lower utilization levels of dental services. The aim of the study was to assess the influence of income and financial subsidies on the utilization of dental care services among persons with IDD in Singapore. METHODS: Between August 2020 and August 2021, a cross-sectional study was conducted via centres offering Early Intervention Programme for Infants and Children, special education schools and adult associations in Singapore serving persons with IDD...
April 21, 2024: Community Dentistry and Oral Epidemiology
https://read.qxmd.com/read/38644493/school-health-promotion-and-fruit-and-vegetable-consumption-in-secondary-schools-a-repeated-cross-sectional-multilevel-study
#36
JOURNAL ARTICLE
Lisanne Vonk, Iris Eekhout, Tim Huijts, Mark Levels, Maria W J Jansen
BACKGROUND: Worldwide, recommendations for fruit and vegetable consumption are not met, which can cause chronic diseases. Especially adolescence is an important phase for the development of health behaviours. Therefore, in the Netherlands, the Healthy School program was established to aid schools in promoting healthy lifestyles among their students. We examined to what extent the variation between secondary schools regarding students' fruit and vegetable consumption could be explained by differences between schools regarding Healthy School certification, general school characteristics, and the school population...
April 22, 2024: BMC Public Health
https://read.qxmd.com/read/38643962/adipose-tissue-in-the-small-airways-how-much-is-enough-to-drive-functional-changes
#37
JOURNAL ARTICLE
G M Donovan, C J Wang, P B Noble, K C W Wang
Obesity is a contributing factor to asthma severity; while it has long been understood that obesity is related to greater asthma burden, the mechanisms though which this occurs have not been fully elucidated. One common explanation is that obesity mechanically reduces lung volume through accumulation of adipose tissue external to the thoracic cavity. However, it has been recently demonstrated that there is substantial adipose tissue within the airway wall itself, and that the presence of adipose tissue within the airway wall is related to body mass index...
April 19, 2024: Journal of Theoretical Biology
https://read.qxmd.com/read/38643942/protein-kinase-c-inhibition-reduces-critical-weight-loss-and-improves-functional-outcome-after-experimental-subarachnoid-haemorrhage
#38
JOURNAL ARTICLE
Jesper P Bömers, Anja Holm, Spyridoula Kazantzi, Professor Lars Edvinsson, Professor Tiit I Mathiesen, Kristian A Haanes
OBJECTIVES: Subarachnoid haemorrhage (SAH) carries a high burden of morbidity and mortality. One in three patients develop vasospasm, which is associated with Delayed Cerebral Ischemia. The pathophysiology includes vasoconstrictor receptor upregulation in cerebral arteries. The protein kinase C - inhibitor RO-31-7549 reduces the expression of several vasoconstrictor receptors and normalizes cerebral blood flow in experimental SAH but functional and behavioural effects are unknown. This study was undertaken to analyse functional outcomes up to 14 days after experimental SAH...
April 19, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38643704/milligram-scale-enantioresolution-of-promethazine-and-its-main-metabolites-determination-of-their-absolute-configuration-and-assessment-of-enantioselective-effects-on-human-sy-sy5y-cells
#39
JOURNAL ARTICLE
Maria Miguel Coelho, Inês Costa, Ana Carolina Ferreira de Albuquerque, Fernando Martins Dos Santos Junior, Bárbara Silva, Renata Silva, Carla Fernandes, Fernando Remião, Maria Elizabeth Tiritan
The misuse of pharmaceuticals has significantly increased in recent decades, becoming a major public health concern. The risks associated with medication misuse are particularly high in cases of overdose, especially when the active substances are chiral, as enantioselectivity plays an important role in toxicity. Promethazine (PMZ) is a chiral antihistamine marketed as a racemate and it is misused in "Purple Drank", a recreational drug beverage, that combines codeine and/or PMZ, with soda or alcohol leading to serious health consequences and fatalities in consumers around the world, particularly among teenagers...
April 15, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38643557/-why-can-t-i-say-people-s-names-alexinomia-as-a-widespread-psychological-phenomenon
#40
JOURNAL ARTICLE
Alexis Bergert, Lisa Welleschik, Thomas Ditye
Psychological research has recently proposed alexinomia, characterised by an inhibited behaviour in saying names, as a distinct psychosocial phenomenon. Alexinomia is associated with anxiety and avoidance behaviours with regards to saying names and thus severely impacts every day social interactions and relationships. This study aimed to explore the prevalence of this newly established and poorly understood psychological phenomenon and to further determine its impact on everyday life. For this purpose, online advice and discussion forums were systematically searched for threads on and mentions of problems with saying names...
April 20, 2024: Acta Psychologica
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