keyword
https://read.qxmd.com/read/38497582/chronic-social-defeat-stress-induces-the-down-regulation-of-the-nedd4l-glt-1-ubiquitination-pathway-in-the-prefrontal-cortex-of-mice
#1
JOURNAL ARTICLE
Aika Kosuge, Kazuo Kunisawa, Tsubasa Iida, Bolati Wulaer, Tomoki Kawai, Moeka Tanabe, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
Stressful life events contribute to the onset of major depressive disorder (MDD). We recently demonstrated abnormalities in ubiquitination in the pathophysiology of MDD. However, the underlying molecular mechanisms remain unclear. We investigated the involvement of the ubiquitination system-mediated glutamatergic dysfunction in social impairment induced by chronic social defeat stress (CSDS). Adult C57BL/6J mice were exposed to aggressor ICR male mice for 10 consecutive days. Social impairment was induced by CSDS in the social interaction test 1 days after the last stress exposure...
March 18, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38496917/antidepressants-and-survival-in-glioma-a-registry-based-retrospective-cohort-study
#2
JOURNAL ARTICLE
Sonja Edström, Barbro Numan Hellquist, Maria Sandström, Sajna Anand Sadanandan, Benny Björkblom, Beatrice Melin, Rickard L Sjöberg
BACKGROUND: Depression and treatment with antidepressant medication is common in patients with malignant glioma. However, the extent to which antidepressants may affect the disease is not fully understood. Therefore, the purpose of the present study was to investigate possible associations between treatment with antidepressant medication and survival in glioma patients. METHODS: We performed a registry-based cohort study including 1231 patients with malignant glioma (WHO grades 2, 3, and 4) having undergone surgery, and 6400 matched controls without glioma...
April 2024: Neuro-oncology Practice
https://read.qxmd.com/read/38496915/antidepressants-and-survival-in-glioma-unraveling-a-complex-puzzle
#3
EDITORIAL
Alasdair G Rooney
No abstract text is available yet for this article.
April 2024: Neuro-oncology Practice
https://read.qxmd.com/read/38496607/multichannel-tdcs-with-advanced-targeting-for-major-depressive-disorder-a-tele-supervised-at-home-pilot-study
#4
Giulio Ruffini, Ricardo Salvador, Davide Cappon, Francesca Castaldo, Thais Baleeiro, Alvaro Pascual-Leone
PURPOSE: Proof-of-principle human studies suggest that transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (L-DLPFC) may improve the clinical symptoms of depression. This multicenter study (N=35) tested remotely supervised and repeated daily multichannel tDCS delivered at home designed to target the L-DLPFC in a group of patients with major depressive disorder (MDD). The main objectives of the study were to assess the feasibility and safety of home-based, remotely-supervised tDCS for patients with MDD...
March 4, 2024: medRxiv
https://read.qxmd.com/read/38496461/effects-of-electroconvulsive-shock-on-the-function-circuitry-and-transcriptome-of-dentate-gyrus-granule-neurons
#5
Adrienne N Santiago, Julia Castello-Saval, Phi Nguyen, Hannah M Chung, Victor M Luna, Rene Hen, Wei-Li Chang
Therapeutic use of electroconvulsive shock (ECS) is 75% effective for the remission of treatment-resistant depression. Like other more common forms of antidepressant treatment such as fluoxetine, ECS has been shown to increase neurogenesis in the hippocampal dentate gyrus of rodent models. Yet the question of how ECS-induced neurogenesis supports improvement of depressive symptoms remains unknown. Here, we show that ECS-induced neurogenesis is necessary to improve depressive-like behavior of mice exposed to chronic corticosterone (Cort)...
March 5, 2024: bioRxiv
https://read.qxmd.com/read/38496451/opioid-receptor-expressing-neurons-of-the-central-amygdala-gate-behavioral-effects-of-ketamine-in-mice
#6
Matthew B Pomrenze, Sam Vaillancourt, Pierre Llorach, Daniel Ryskamp Rijsketic, Austen B Casey, Nicholas Gregory, Juliana S Salgado, Robert C Malenka, Boris D Heifets
Ketamine has anesthetic, analgesic, and antidepressant properties which may involve multiple neuromodulatory systems. In humans, the opioid receptor (OR) antagonist naltrexone blocks the antidepressant effect of ketamine. It is unclear whether naltrexone blocks a direct effect of ketamine at ORs, or whether normal functioning of the OR system is required to realize the full antidepressant effects of treatment. In mice, the effect of ketamine on locomotion, but not analgesia or the forced swim test, was sensitive to naltrexone and was therefore used as a behavioral readout to localize the effect of naltrexone in the brain...
March 6, 2024: bioRxiv
https://read.qxmd.com/read/38496221/orexin-receptor-antagonists-as-adjunct-drugs-for-the-treatment-of-depression-a-mini-meta-analysis
#7
REVIEW
Mustafa Uğurlu
INTRODUCTION: There is growing interest in the efficacy of orexin receptor antagonists (ORA), one of the new psychopharmacological agents used in the treatment of insomnia, in other psychiatric disorders such as depression. METHODS: This meta-analysis was conducted in accordance with PRISMA requirements. Literature searches were conducted using PubMed, Scopus and EBSCO (Medline) databases. Search words were (depression OR mood disorder OR affective disorder) AND (orexin OR orx OR hypocretin OR orx1 OR orx2 OR orexin receptor antagonist OR almorexant OR suvorexant OR lemborexant OR daridorexant OR seltorexant OR vornorexant OR filorexant)...
2024: Noro Psikiyatri Arsivi
https://read.qxmd.com/read/38496198/zopiclone-induced-methemoglobinemia-a-case-report-highlighting-how-the-treatment-differs-in-patients-on-serotonergic-medication
#8
Lionel Kee Yon See, Grace Min Yi Fong, Dorcas Lim
Zopiclone is a sedative-hypnotic that is increasingly being used for insomnia, especially among patients with depression. The side effects of zopiclone include nausea, vomiting, headache, giddiness, sedation, altered mental status, and coma. Here, we describe a rare case of a patient with underlying depression who overdosed on zopiclone, resulting in a presentation of drowsiness and dyspnea. A diagnosis of methemoglobinemia was made only through astute observation of the presence of a saturation gap, poor oxygen saturation despite high flow oxygen supplementation, and the arterial blood gas sample appearing chocolate brown in color...
February 2024: Curēus
https://read.qxmd.com/read/38495961/ultrasound-guided-cryoneurolysis-for-the-treatment-of-painful-diabetic-neuropathy-of-the-foot-a-case-series
#9
Igor Filipovski, Rodney A Gabriel, Rene Kestenholz
Diabetic peripheral neuropathy is one of the most common causes of chronic neuropathic pain. Treatment of peripheral neuropathy has been limited to either treating the underlying cause or using medications, such as tricyclic antidepressants and anticonvulsants, to manage the symptoms. In this case series, we report the use of ultrasound-guided percutaneous cryoneurolysis of the superficial peroneal nerves to treat diabetic neuropathy of the feet. This demonstrates the potential effectiveness and safety of using cryoneurolysis for painful peripheral diabetic neuropathy...
March 2024: Curēus
https://read.qxmd.com/read/38495401/management-of-anhedonia-after-epilepsy-surgery
#10
JOURNAL ARTICLE
Gerardo Maria de Araujo Filho, Antonio L Teixeira
Anhedonia is clinically defined as difficulty or inability to feel pleasure or to be motivated to perform activities that were previously pleasurable. Anhedonia is a core feature of depressive disorders but can be present in other conditions such as substance use and anxiety disorders. Herein we report the case of a 34-year-old female who developed marked anhedonia after left cortico-amygdalohippocampectomy. Despite optimal seizure control, the person struggled with anhedonia and other depressive symptoms. After ruling out medico-neurologic complications, she was prescribed with a selective serotonin reuptake inhibitor and cognitive-behavioral therapy...
2024: Epilepsy & behavior reports
https://read.qxmd.com/read/38495098/anti-neuroinflammatory-effect-of-hydroxytyrosol-a-potential-strategy-for-anti-depressant-development
#11
JOURNAL ARTICLE
Shuaiguang Li, Huarong Shao, Ting Sun, Xinyan Guo, Xiaoyuan Zhang, Qingkai Zeng, Shaoying Fang, Xiaoyu Liu, Fan Wang, Fei Liu, Peixue Ling
Introduction: Depression is a complex psychiatric disorder with substantial societal impact. While current antidepressants offer moderate efficacy, their adverse effects and limited understanding of depression's pathophysiology hinder the development of more effective treatments. Amidst this complexity, the role of neuroinflammation, a recognized but poorly understood associate of depression, has gained increasing attention. This study investigates hydroxytyrosol (HT), an olive-derived phenolic antioxidant, for its antidepressant and anti-neuroinflammatory properties based on mitochondrial protection...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38494988/associations-between-psychosocial-work-environment-factors-and-first-time-and-recurrent-treatment-for-depression-a-prospective-cohort-study-of-24-226-employees
#12
JOURNAL ARTICLE
J Mathisen, T-L Nguyen, I E H Madsen, T Xu, J H Jensen, J K Sørensen, R Rugulies, N H Rod
AIMS: Adverse factors in the psychosocial work environment are associated with the onset of depression among those without a personal history of depression. However, the evidence is sparse regarding whether adverse work factors can also play a role in depression recurrence. This study aimed to prospectively examine whether factors in the psychosocial work environment are associated with first-time and recurrent treatment for depression. METHODS: The study included 24,226 participants from the Danish Well-being in Hospital Employees study...
March 18, 2024: Epidemiology and Psychiatric Sciences
https://read.qxmd.com/read/38494743/the-effect-of-flexible-cognitive-behavioural-therapy-and-medical-treatment-including-antidepressants-on-post-traumatic-stress-disorder-and-depression-in-traumatised-refugees-pragmatic-randomised-controlled-clinical-trial-corrigendum
#13
JOURNAL ARTICLE
Caecilie Böck Buhmann, Merete Nordentoft, Morten Ekstroem, Jessica Carlsson, Erik Lykke Mortensen
No abstract text is available yet for this article.
March 18, 2024: British Journal of Psychiatry
https://read.qxmd.com/read/38494193/environmentally-benign-first-derivative-synchronous-spectrofluorimetry-for-the-analysis-of-two-binary-mixtures-containing-duloxetine-with-avanafil-or-tadalafil-in-spiked-plasma-samples
#14
JOURNAL ARTICLE
Walaa Nabil Abd-AlGhafar, Rasha Abo Shabana, Rania El-Shaheny, Manar M Tolba
Antidepressants can cause sexual dysfunction side effects, necessitating the co-administration of phosphodiesterase type 5 inhibitors. The simultaneous determination of these drugs in biological fluids is critical for therapeutic drug monitoring. For the first time, two binary mixtures containing duloxetine with either avanafil or tadalafil were estimated utilizing simple green spectrofluorimetric methods without the need for a previous separation step. The study was based on first derivative synchronous spectrofluorimetry in ethanol using a change in wavelength difference (∆λ) of 20 and 25 nm for the first and second combinations, respectively...
March 2024: Luminescence: the Journal of Biological and Chemical Luminescence
https://read.qxmd.com/read/38494134/multidimensional-assessment-of-adverse-events-of-bupropion-a-large-scale-data-analysis-from-the-faers-database
#15
JOURNAL ARTICLE
Rongrong Lu, Ying Jiang, Zhiqiang Du, Qin Zhou, Yuan Shen, Haohao Zhu
OBJECTIVE: Bupropion, a monocyclic antidepressant, aids in smoking cessation, treats major depression, and prevents severe depression in seasonal affective disorder patients. Yet, its adverse reactions remain insufficiently studied. METHODS: All data from the raw data packages for 78 quarters from the 1st quarter of 2004 to the 2nd quarter of 2023 were extracted from the FDA Adverse Event Reporting System (FAERS) database and imported into the SAS9.4 software for data cleaning and analysis...
March 15, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38494007/running-exercise-improves-astrocyte-loss-morphological-complexity-and-astrocyte-contacted-synapses-in-the-hippocampus-of-cus-induced-depression-model-mice
#16
JOURNAL ARTICLE
Yue Li, Yanmin Luo, Peilin Zhu, Xin Liang, Jing Li, Xiaoyun Dou, Li Liu, Lu Qin, Mei Zhou, Yuhui Deng, Lin Jiang, Shun Wang, Wenyu Yang, Jing Tang, Yong Tang
Although the antidepressant effects of running exercise have been widely reported, further research is still needed to determine the structural bases for these effects. Astrocyte processes physically contact many synapses and directly regulate the numbers of synapses, but it remains unclear whether running exercise can modulate astrocyte morphological complexity and astrocyte-contacted synapses in the hippocampus of the mice with depressive-like behavior. Male C57BL/6 J mice underwent four weeks of running exercise after four weeks of chronic unpredictable stress (CUS)...
March 15, 2024: Pharmacology, Biochemistry, and Behavior
https://read.qxmd.com/read/38493750/the-efficacy-of-electroconvulsive-therapy-in-adolescent-major-depressive-disorder-with-suicidal-ideation-a-propensity-score-matched-retrospective-cohort-study
#17
JOURNAL ARTICLE
Xinglian Wang, Hao Ren, Zheng Zhang, Xiufen Zhong, Qinghua Luo, Yan Huang, Haitang Qiu
BACKGROUND: More evidence is needed to validate the use of ECT in adolescent depression. This study aims to compare the effectiveness of electroconvulsive therapy (ECT) to conventional medication therapy for adolescents with major depression with suicidal ideation. METHODS: In this retrospective cohort study, we reviewed inpatient records from the First Affiliated Hospital of Chongqing Medical University spanning December 2016 to June 2021. We focused on adolescents diagnosed with severe depression presenting with suicidal tendencies...
March 7, 2024: Asian Journal of Psychiatry
https://read.qxmd.com/read/38493365/frequencies-of-cyp2c19-and-cyp2d6-gene-variants-in-a-german-inpatient-sample-with-mood-and-anxiety-disorders
#18
JOURNAL ARTICLE
Maike Scherf-Clavel, Heike Weber, Stefan Unterecker, Daniel J Müller, Jürgen Deckert
OBJECTIVES: Previous results demonstrated that CYP2D6 and CYP2C19 gene variants affect serum concentrations of antidepressants. We implemented a PGx service determining gene variants in CYP2D6 and CYP2C19 in our clinical routine care and report on our first patient cohort. METHODS: We analyzed CYP2D6 and CYP2C19 allele, genotype, and phenotype frequencies, and actionable pharmacogenetic variants in this German psychiatric inpatient cohort. Two-tailed z-test was used to investigate for differences in CYP2D6 and CYP2C19 phenotypes and actionable/non-actionable genetic variant frequencies between our cohort and reference cohorts...
March 17, 2024: World Journal of Biological Psychiatry
https://read.qxmd.com/read/38492883/pgc-1%C3%AE-in-the-hippocampus-mediates-depressive-like-and-stress-coping-behaviours-and-regulates-excitatory-synapses-in-the-dentate-gyrus-in-mice
#19
JOURNAL ARTICLE
Yuhui Deng, Xin Liang, Yue Li, Lin Jiang, Jin Wang, Jing Tang, Jing Li, Yuhan Xie, Kai Xiao, Peilin Zhu, Yijing Guo, Yanmin Luo, Yong Tang
Decreased hippocampal synaptic plasticity is an important pathological change in stress-related mood disorders, including major depressive disorder. However, the underlying mechanism is unclear. PGC-1α, a transcriptional coactivator, is a key factor in synaptic plasticity. We investigated the relationships between changes in hippocampal PGC-1α expression and depressive-like and stress-coping behaviours, and whether they are related to hippocampal synapses. Adeno-associated virus was used to alter hippocampal PGC-1α expression in male C57BL/6 mice...
March 14, 2024: Neuropharmacology
https://read.qxmd.com/read/38492791/deciphering-the-antidepressant-effects-of-rosa-damascena-essential-oil-mediated-through-the-serotonergic-synapse-signaling-pathway
#20
JOURNAL ARTICLE
Ning Xia, Jie Wang, Qiuting Guo, Jiawei Duan, Xuan Wang, Peijie Zhou, Jinkai Li, Tiantian Tang, Taotao Li, Huiting Li, Zhenfeng Wu, Ming Yang, Jing Sun, Dongyan Guo, Xing Chang, Xiaofei Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Rosa damascena is an ancient plant with significance in both medicine and perfumery that have a variety of therapeutic properties, including antidepressant, anti-anxiety, and anti-stress effects. Rose damascena essential oil (REO) has been used to treat depression, anxiety and other neurological related disorders in Iranian traditional medicine. However, its precise mechanism of action remains elusive. AIM OF THE STUDY: The aim of this study was to investigate the impact and mechanism underlying the influence of REO on chronic unpredictable mild stress (CUMS) rats...
March 14, 2024: Journal of Ethnopharmacology
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