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https://www.readbyqxmd.com/read/28938005/recombinant-vaccines-of-a-cd4-t-cell-epitope-promote-efficient-control-of-paracoccidioides-brasiliensis-burden-by-restraining-primary-organ-infection
#1
Rodrigo Assunção Holanda, Julián Esteban Muñoz, Lucas Santos Dias, Leandro Buffoni Roque Silva, Julliana Ribeiro Alves Santos, Sthefany Pagliari, Érica Leandro Marciano Vieira, Tatiane Alves Paixão, Carlos Pelleschi Taborda, Daniel Assis Santos, Oscar Bruña-Romero
Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes. We tested the hypothesis that the immunogenicity of the immunodominant CD4+ T-cell epitope (P10) of Paracoccidioides brasiliensis gp43 antigen might be significantly enhanced by using a hepatitis B virus-derived particle (VLP) as an antigen carrier. This chimera was administered to mice as a (His)6-purified protein (rPbT) or a replication-deficient human type 5 adenoviral vector (rAdPbT) in an immunoprophylaxis assay...
September 22, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28935341/conduct-problems-in-youth-and-the-rdoc-approach-a-developmental-evolutionary-based-view
#2
REVIEW
Peter Fonagy, Patrick Luyten
Problems related to aggression in young people are traditionally subsumed under the header of conduct problems, which include conduct disorder and oppositional defiant disorder. Such problems in children and adolescents are an important societal and mental health problem. In this paper we present an evolutionarily informed developmental psychopathology view of conduct problems inspired by the NIMH Research Domain Criteria (RDoC) initiative. We assume that while there are many pathways to conduct problems, chronic or temporary impairments in the domain of social cognition or mentalizing are a common denominator...
September 8, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28934981/the-effect-of-psychological-interventions-on-the-prevention-of-chronic-pain-in-adults-a-systematic-review-protocol
#3
Mélanie Bérubé, Céline Gélinas, Manon Choinière, Nancy Feeley, Géraldine Martorella, Stefan Parent, David L Streiner
BACKGROUND: Numerous psychological risk and protective factors have been identified as contributing to or preventing the development of the prevalent issue of chronic pain. Systematic reviews of studies on psychological interventions that tackle these factors have shown limited effects on chronic pain. Therefore, implementing psychological interventions before pain becomes chronic has been put forward. However, the efficacy of such interventions in preventing the transition from acute to chronic pain has not yet been systematically assessed...
September 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28934635/community-social-support-as-a-protective-factor-against-suicide-a-gender-specific-ecological-study-of-75-regions-of-23-european-countries
#4
Nuša Zadravec Šedivy, Tina Podlogar, David C R Kerr, Diego De Leo
By studying differences in suicide rates among different geographical regions one may identify factors connected to suicidal behaviour on a regional level. Many studies have focused on risk factors, whereas less is known about protective factors, such as social support. Using suicide rates and data from the European Social Survey (ESS) we explore the association between regional level social support indicator and suicide rates in 23 European countries in 2012. Linear multiple regression analyses using region as the unit of analysis revealed inverse relationships between mean respondent valuing of social support and suicide rates for both genders, with some indication of a stronger relationship among men...
September 18, 2017: Health & Place
https://www.readbyqxmd.com/read/28934628/the-heat-exposure-integrated-deprivation-index-heidi-a-data-driven-approach-to-quantifying-neighborhood-risk-during-extreme-hot-weather
#5
Nikolas Krstic, Weiran Yuchi, Hung Chak Ho, Blake B Walker, Anders J Knudby, Sarah B Henderson
Mortality attributable to extreme hot weather is a growing concern in many urban environments, and spatial heat vulnerability indexes are often used to identify areas at relatively higher and lower risk. Three indexes were developed for greater Vancouver, Canada using a pool of 20 potentially predictive variables categorized to reflect social vulnerability, population density, temperature exposure, and urban form. One variable was chosen from each category: an existing deprivation index, senior population density, apparent temperature, and road density, respectively...
September 18, 2017: Environment International
https://www.readbyqxmd.com/read/28934344/care-requirements-for-clients-who-present-after-rape-and-clients-who-presented-after-consensual-sex-as-a-minor-at-a-clinic-in-harare-zimbabwe-from-2011-to-2014
#6
Rebecca E Harrison, Linda Pearson, Michael Vere, Prosper Chonzi, Brian Tafadzwa Hove, Sharon Mabaya, Margaret Chigwamba, Juliana Nhamburo, Juliet Gura, An Vandeborne, Sandra Simons, Daphne Lagrou, Eva De Plecker, Rafael Van den Bergh
STUDY GOALS: To describe the differences between clients presenting after rape and clients who have consented to sex as a minor to an SGBV clinic in Harare, Zimbabwe, and how these differences affect their care requirements. BACKGROUND: Adolescents and adults presenting at the specialized Sexual and Gender Based Violence clinic in Harare are offered a standardised package of free medical and psychosocial care. Zimbabwe has an HIV prevalence of 14%, so prevention of HIV infection using PEP for those that present within 72 hours is a key part of the response...
2017: PloS One
https://www.readbyqxmd.com/read/28934087/high-risk-behaviours-for-the-f%C3%A5-tus-in-pregnant-women-the-medicolegal-and-judicial-aspects
#7
P Desaunay, A Cerf-Hollender, G Andro, P Gerardin, M Dreyfus, F Guenole
Pregnancy is a period of psychological change which may lead to difficulties of adaptation and psychological suffering and give rise to high-risk behaviours for the fœtus in pregnant women. These risk behaviours, which are defined by certain authors as a form of "maltreatment" of the fœtus, usually spring from the psychological distress of the pregnant woman but are not recognised as a specific medical disorder. We illustrate the difficulties encountered in the identification of, and the specific intervention in, these situations through the clinical case of a pregnant drugs-dependent patient subjected to several stress factors who, in addition to consuming substances, developed high-risk behaviours for herself and her pregnancy: self-endangerment under the influence of substances, falls or refusals of treatment...
May 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28933339/incidence-and-outcome-of-lupus-nephritis-in-french-polynesia%C3%A2
#8
Antoine Delarche, Catherine Lumbroso, Alain Fournier, Ronan Delaval, Jacques Pourrat, Pascale Testevuide, Sylvie Leou, Christophe Cordonnier, Dominique Chauveau, Stanislas Faguer
OBJECTIVE: Outcomes of systemic lupus erythematosus (SLE) and lupus nephritis (LN) are highly heterogeneous among some populations because of interactions between genetic, epigenetic, environmental, and socioeconomic factors. A better characterization of social and ethnic disparities in mixed populations may thus help to develop individualized treatment regimens. MATERIALS AND METHODS: Retrospective observational study including all patients with LN diagnosed between January 1993 and January 2014 in the only Nephrology Department of French Polynesia...
September 21, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28931081/female-reproductive-success-and-calf-survival-in-a-north-sea-coastal-bottlenose-dolphin-tursiops-truncatus-population
#9
Kevin P Robinson, Texa M C Sim, Ross M Culloch, Thomas S Bean, Isabel Cordoba Aguilar, Sonja M Eisfeld, Miranda Filan, Gary N Haskins, Genevieve Williams, Graham J Pierce
Between-female variation in reproductive output provides a strong measure of individual fitness and a quantifiable measure of the health of a population which may be highly informative to management. In the present study, we examined reproductive traits in female bottlenose dolphins from the east coast of Scotland using longitudinal sightings data collected over twenty years. From a total of 102 females identified between 1997 and 2016, 74 mothers produced a collective total of 193 calves. Females gave birth from 6 to 13 years of age with a mean age of 8...
2017: PloS One
https://www.readbyqxmd.com/read/28930519/divergent-impact-of-gender-in-advancement-of-liver-injuries-diseases-and-carcinogenesis
#10
Subhrajit Biswas, Sampa Ghose
Several investigations have revealed that liver diseases exhibit gender biases, but identifying the root causes of such biases has been challenging. Evidence of gender differences in liver function is present from the early stage of embryonic development. The differences in access to care and treatment as well as diagnostic deliberation may affect gender-specific differences in liver disease progression. Apart from the pathogenesis, xenobiotic metabolism, immune responses, gene expressions, mitochondrial function, lipid composition, and enzyme activities also differ in this sexually dimorphic organ...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28930303/mitigation-measures-of-electromagnetic-field-exposure-in-the-vicinity-of-high-frequency-welders
#11
Bartłomiej Zubrzak, Pawel Bieńkowski, Pawel Cała
BACKGROUND: Presented information about the welding process and equipment, focusing on the emission of electromagnetic field (EMF) with levels significant in terms of the labor safety regulations in force in Poland - the ordinances of the Minister of Family, Labour and Social Policy that came into force on June 27, 2016 and June 29, 2016 - emerged due to harmonization with EU directive 2013/35/EU of 26 June 2013 of the European Parliament and the Council. They presented methods of determination of the EMF distribution in the welding machine surroundings and analyzed the background knowledge from the available literature...
September 20, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28929879/safer-muslim-motherhood-social-conditions-and-maternal-mortality-in-the-muslim-world
#12
Kylea Laina Liese, Angela B Maeder
The greatest variation in maternal mortality is among poor countries and wealthy countries that rely on emergency obstetric technology to save a woman's life during childbirth. However, substantial variation in maternal mortality ratios (MMRs) exists within and among poor countries with uneven access to advanced obstetric services. This article examines MMRs across the Muslim world and compares the impact of national wealth, female education, and skilled birth attendants on maternal mortality. Understanding how poor countries have lowered MMRs without access to expensive obstetric technologies suggests that certain social variables may act protectively to reduce the maternal risk for life-threatening obstetric complications that would require emergency obstetric care...
September 20, 2017: Global Public Health
https://www.readbyqxmd.com/read/28929728/-undocumented-immigrants-what-do-we-know-about-their-health
#13
Giovanni Baglio, Raffaele Di Palma, Erica Eugeni, Antonio Fortino
In Italy, immigrants represent a "fuzzy" set, to which it is difficult to apply dichotomous categories as a classification (i.e., regular/irregular, economic/forced, etcetera). These categories lose its meaning when used to study health phenomena. Rather, the epidemiological profile of such a heterogeneous population depends on the varying influence of health determinants in the life-course of migration. This article builds on those assumptions, and analyses the health of irregularly- staying immigrants by adopting a global approach to the migration phenomenon...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28929716/-developing-an-algorithm-based-on-health-and-social-sources-to-stratify-general-population-in-different-levels-of-health-socio-sanitary-frailty-and-disability
#14
Laura Andreoni, Antonio Giampiero Russo
OBJECTIVES: to describe an innovative algorithm to classify the general population, in homogeneous groups of severity and complexity of disease and real needs, by using three dimensions: health, frailty, and disability. DESIGN: retrospective cohort study. SETTING AND PARTICIPANTS: the study includes the population covered by the Agency for health protection of Metropolitan Area of Milan (3,4 million of habitants). We identified two cohorts of residents: the first at 01...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28929637/the-public-awareness-of-stillbirth-an-irish-population-study
#15
D Nuzum, S Meaney, K O'Donoghue
OBJECTIVE: To evaluate the general population's awareness of stillbirth. DESIGN: A cross sectional telephone population survey. SETTING: A nationally representative sample of the Irish adult population. SAMPLE: 999 members of the Irish population selected by random digit dialling. METHODS: Data were analysed using descriptive and inferential statistics. Binary logistic regression was used to assess the odds of identifying risk factors for stillbirth...
September 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28929566/protracted-dendritic-growth-in-the-typically-developing-human-amygdala-and-increased-spine-density-in-young-asd-brains
#16
R K Weir, M D Bauman, B Jacobs, C M Schumann
The amygdala is a medial temporal lobe structure implicated in social and emotional regulation. In typical development (TD), the amygdala continues to increase volumetrically throughout childhood and into adulthood, while other brain structures are stable or decreasing in volume. In autism spectrum disorder (ASD), the amygdala undergoes rapid early growth, making it volumetrically larger in children with ASD compared to TD children. Here we explore: 1) if dendritic arborization in the amygdala follows the pattern of protracted growth in TD and early overgrowth in ASD and 2), if spine density in the amygdala in ASD cases differs from TD from youth to adulthood...
September 20, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28929562/seroepidemiological-trend-of-strongyloidiasis-in-the-bolivian-chaco-1987-2013-in-the-absence-of-disease-specific-control-measures
#17
Michele Spinicci, Fabio Macchioni, Antonia Mantella, Simona Gabrielli, Mimmo Roselli, David Rojo Mayaregua, Joaquín Monasterio Pinckert, Herlan Gamboa Barahona, Grover Adolfo Paredes, Percy Halkyer, Gabriella Cancrini, Piero Olliaro, Antonio Montresor, Alessandro Bartoloni
OBJECTIVES: The prevalence of Strongyloides stercoralis infections is grossly underestimated because infections go mostly undetected, though they can persist for a lifetime due to the auto-infective cycle. In the Bolivian Chaco, the prevalence of soil-transmitted nematodes dropped dramatically in the past 25 years, but the mebendazole used for preventive chemotherapy has no effect on S. stercoralis. Meanwhile, the prevalence of intestinal protozoan infections remains unchanged. We compared S...
September 20, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28928317/tobacco-industry-interference-a-review-of-three-south-east-asian-countries
#18
Mary Assunta, Bungon Ritthiphakdee, Widyastuti Soerojo, May Myat Cho, Worrawan Jirathanapiwat
BACKGROUND: The WHO Framework Convention on Tobacco Control (FCTC) Article 5.3 requires governments to protect tobacco control policies from the commercial interest of the tobacco industry (TI). TI interference is the biggest barrier to implementing comprehensive tobacco control measures. OBJECTIVE: This paper reviews the extent of the TI's interference in tobacco control policy development in three countries, Thailand, Myanmar, and Indonesia, and the governments' efforts to protect these policies...
September 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28926876/-advances-in-the-research-of-characteristics-and-treatment-of-burns-in-the-elderly
#19
R Liu, Z Y Li
With the development of society and the improvement of medical level, the average life span of human has been increasing year by year. The proportion of elderly burn patients is also increasing yearly, which has become a social problem that can not be ignored. Because of physiological characteristics, such as decreased function of heart, lung, and kidney, degenerative changes of neural system, reduced gastrointestinal function and immunological function, and mostly accompanied by primary diseases of diabetes and cardiovascular diseases, elderly burn patients suffer from high shock rate and mortality, and their wounds are not easy to heal...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28926778/korean-immigrants-don-t-buy-health-insurance-the-influences-of-culture-on-self-employed-korean-immigrants-focusing-on-structure-and-functions-of-social-networks
#20
Hyunsung Oh, Chung Hyeon Jeong
Culture has been pinpointed as a culprit of disparities in health insurance coverage between Korean immigrants and other ethnic groups. This study explored specific mechanisms by which culture influences a decision to buy health insurance among self-employed Korean immigrants living in ethnic enclaves by focusing on the structure and functions of social networks. Between March and June 2015, we recruited 24 Korean immigrant adults (aged 18 or older) who identified as self-employed and being uninsured for substantial periods before 2014 in Southern California...
September 12, 2017: Social Science & Medicine
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