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https://www.readbyqxmd.com/read/29900030/primary-solitary-retro-clival-amyloidoma
#1
Julia R Schneider, Kevin Kwan, Kay O Kulason, Lukas J Faltings, Stephanie Colantonio, Scott Safir, Tina Loven, Jian Yi Li, Karen S Black, B Todd Schaeffer, Mark B Eisenberg
Background: Amyloidosis encompasses a group of disorders sharing the common feature of intercellular deposition of amyloid protein by several different pathogenetic mechanisms. Primary solitary amyloidosis, or amyloidoma, is a rare subset of amyloidosis in which amyloid deposition is focal and not secondary to a systemic process or plasma cell dyscrasia. Case Description: This 84-year-old female presented with history of multiple syncopal episodes, dysphagia, and ataxia...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29893955/endoscopic-endonasal-focal-transclival-medial-condylectomy-approach-for-resection-of-a-foramen-magnum-meningioma-2-dimensional-operative-video
#2
Juan M Revuelta Barbero, Alaa S Montaser, Mostafa Shahein, André Beer-Furlan, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello
The endoscopic endonasal approach (EEA) provides direct access to foramen magnum meningiomas; however, it often requires extensive exposure including septal flap elevation with septum removal, complete sphenoidotomy, and panclivectomy.We present a case of a 54-yr-old-female with an incidental foramen magnum lesion followed up with serial imaging who presented 10 mo later with progressive neck discomfort and episodes of dizziness, with confirmed tumor progression and further brainstem compression. A focal transclival EEA with medial condylectomy was performed preserving the upper two-thirds of the clivus, the nasal septum, and the sphenoid sinus...
June 11, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29857867/relationship-between-basilar-invagination-and-brachycephaly-in-northeastern-brazil
#3
José J C Nascimento, Nayyara M F Carreiro, Gabriela T Oliveira, Elayne C O Ribeiro, Maurus M A Holanda, Eulâmpio J S Neto, Severino A Araújo-Neto
BACKGROUND: Basilar invagination (BI) is an abnormality characterized by a superior projection at the craniovertebral junction (CVJ). The high prevalence of BI in Northeastern Brazil associated with brachycephaly, which is measured by the cranial index (CI), has been widely reported by several neurosurgeons and radiologists from that region since the 1950s. However, strong evidence for this relationship is still pending. The aim of this study is to investigate whether there is a relationship between BI and CI in a sample with participants from Northeastern Brazil...
July 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29777006/in-vivo-characterization-and-quantification-of-neurofibrillary-tau-pet-radioligand-18-f-mk-6240-in-humans-from-alzheimer-s-disease-dementia-to-young-controls
#4
Tobey J Betthauser, Karly A Cody, Matthew D Zammit, Dhanabalan Murali, Alexander K Converse, Todd E Barnhart, Charles K Stone, Howard A Rowley, Sterling C Johnson, Bradley T Christian
Tau positron emission tomography (PET) imaging has potential for elucidating changes in the deposition of neuropathological tau aggregates that are occurring during the progression of Alzheimer's disease (AD). This work investigates in vivo kinetics, quantification strategies and imaging characteristics of a novel tau PET radioligand [18 F]MK-6240 in humans. Methods: Fifty-one individuals ranging from cognitively normal young controls to persons with dementia underwent T1-weighted magnetic resonance imaging (MRI), and [11 C]PiB and [18 F]MK-6240 PET imaging...
May 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29775030/-endoscopic-transnasal-approach-for-surgical-treatment-of-skull-base-clival-area-chordomas-report-of-2-cases
#5
J Ma, P Fang, D Wang, Y J Liu
The case 1 performanced submandibular trauma because of the faint Suddenly. There were no obvious abnormality in physical examination. CT result showed that the tumour located in the lower clivus, and the atlas was infringed. MRI imaging showed the tumour located in the both sides of the internal carotid artery, infringed clivus and atlas front, forwarded into the nasal cavity and oral cavity. The case 2 performanced the left nose stuffy and increased gradually, nasopharyngeal mirror showed the left nasal cavity filled with new life...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770288/infrasellar-endoscopic-endonasal-approach-for-a-pituitary-adenoma-extending-into-the-third-ventricle-with-anterior-displacement-of-the-pituitary-gland
#6
Georgios A Zenonos, Eric W Wang, Juan Carlos Fernandez-Miranda
Objectives  The current video presents the nuances of the infrasellar endoscopic endonasal approach for a pituitary adenoma extending into the third ventricle, with anterior displacement of the pituitary gland. Design  The video analyzes the presentation, preoperative workup and imaging, surgical steps and technical nuances of the surgery, the clinical outcome, and follow-up imaging. Setting  The patient was treated by a skull base team consisting of a neurosurgeon and an ENT surgeon at a teaching academic institution...
February 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29691145/extended-endoscopic-endonasal-surgery-for-clival-chordoma-and-chondrosarcoma-our-experience-in-14-cases
#7
Diego Culebras, Jorge Torales, Luis Alberto Reyes, Luis Zapata, Sergio García, Pedro Roldán, Cristóbal Langdon, Issam Alobid, Joaquim Enseñat
OBJECTIVE: To report our experience in the management of chordoma and chondrosarcoma with extended endoscopic endonasal surgery. METHOD: We performed a retrospective analysis of a series of 14 patients with clival chordoma or chondrosarcoma who had extended endoscopic endonasal surgery from 2008 to 2016 performed by the same multidisciplinary team. RESULTS: We had fourteen patients (male/female 2:1), with a mean age of 49years for chordoma and 32 for chondrosarcoma...
April 21, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29609578/the-identification-of-h3f3a-mutation-in-giant-cell-tumour-of-the-clivus-and-the-histological-diagnostic-algorithm-of-other-clival-lesions-permit-the-differential-diagnosis-in-this-location
#8
Federica Scotto di Carlo, Giuseppina Divisato, Maurizio Iacoangeli, Teresa Esposito, Fernando Gianfrancesco
BACKGROUND: Giant Cell Tumour of Bone (GCT) is a locally aggressive primary bone tumour that usually occurs at the epiphyses of the long bones of the appendicular skeleton with a tendency to recurrence. Recurrent somatic H3F3A mutations have been described in 92% of GCT cases. GCTs involving the Clivus are extremely rare lesions and less than 15 cases are described in the literature. They represent a surgery challenge and are easily misdiagnosed. Our aim was to reveal if the genetic bases underlying Clival GCTs were the same of GCTs of long bones to improve the diagnosis and treatment...
April 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29600887/prognosis-of-dolichoectasia-in-non-cardioembolic-transient-ischemic-attack-and-minor-stroke
#9
Xinmiao Zhang, Jing Jing, Xingquan Zhao, Liping Liu, Xia Meng, Anxin Wang, Yuesong Pan, David Wang, Yilong Wang, Yongjun Wang
Objectives This study aimed to estimate the prognosis of dolichoectasia in non-cardioembolic transient ischemic attack (TIA) and minor stroke patients. Methods Data were derived from the imaging subgroup of patients in the Clopidogrel in High-risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial. Dolichoectasia was defined as ectasia (basilar artery diameter >4.5 mm) and dolichosis (either basilar artery bifurcation above the suprasellar cistern or lateral to the margin of the clivus or dorsum sellae)...
March 30, 2018: Neurological Research
https://www.readbyqxmd.com/read/29587156/morphometric-analysis-of-posterior-fossa-and-craniovertebral-junction-in-subtypes-of-chiari-malformation
#10
Recep Basaran, Mustafa Efendioglu, Mehmet Senol, Selcuk Ozdogan, Nejat Isik
OBJECTIVES: Chiari malformations (CMs) are a group of disorders defined by anatomic anomalies of the cerebellum, brainstem, and craniovertebral junction (CVJ). In this study, we aimed to investigate morphometry of posterior fossa and CVJ in subtypes of CM and in control group, and to bring up a matter a correlation with demographic data and subtypes of CM. PATIENTS AND METHODS: The study group included patients managed for CM between 2012 and 2016 and control group...
June 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29566386/occipital-condyle-fracture-extending-to-the-inferior-part-of-the-clivus
#11
Necati Ucler, Seyho Cem Yucetas
Although rarely reported in the literature, serious occipital and condylar fractures have been diagnosed more often with the widespread use of computed cranial tomography in traumas. In this paper, a 16-year-old female with a left occipital fracture extending from the left occipital condyle anterior of the hypoglossal canal to the inferior part of the clivus is presented. The fracture which had caused a neurological deficit was cured with conservative treatment. For delayed hypoglossal nerve paralysis due to swelling within the canal, methylprednisolone was started, and a complete cure was attained in about 10 days...
March 22, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29552435/plasmacytoma-of-the-skull-base-a-rare-tumor
#12
Abhilasha Siyag, Tej P Soni, Anil K Gupta, Lalit M Sharma, Naresh Jakhotia, Shantanu Sharma
Plasmacytoma of the skull-base is a rare entity. Differential diagnosis includes chordoma, osteosarcoma, carcinoma nasopharynx, meningioma, metastatic carcinoma, lymphoma, and multiple myeloma. Accurate and precise diagnosis is extremely important for plasmacytoma of the skull-base as its treatment and prognosis is different from other skull-base lesions. A 41-year-old man presented with concerns of headache, diplopia, and left eye strabismus. A magnetic resonance image (MRI) of his brain showed a large expansile mass measuring 51 mm involving the clivus and central skull-base...
January 15, 2018: Curēus
https://www.readbyqxmd.com/read/29538039/endoscopic-endonasal-approach-to-the-upper-cervical-spine-for-decompression-of-the-cervicomedullary-junction-following-occipitocervical-fusion
#13
Ibrahim Hussain, Theodore H Schwartz, Jeffrey P Greenfield
Basilar invagination is defined as abnormal upward and/or posterior displacement of the odontoid leading to ventral compression of the cervicomedullary junction. This condition leads to lower cranial neuropathies, sensorimotor deficits, and myelopathy. These symptoms can persist even after posterior decompression, which is an indication for ventral decompression. Transoral approaches to the upper cervical spine carry significant morbidity, limiting their utility. The endonasal approach to the upper cervical spine presents an alternative for patients with amenable anatomy...
March 13, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29527889/the-limits-of-the-endoscopic-endonasal-transclival-approach-for-posterior-fossa-tumors
#14
Alexandre Bossi Todeschini, Alaa S Montaser, Douglas A Hardesty, Ricardo L Carrau, Daniel M Prevedello
Endoscopic endonasal approaches (EEA) have gained popularity and acceptance in skull base surgery over the last two decades. So-called expanded EEA allow access in the sagittal plane from the frontal sinus to the odontoid process. The endoscopic endonasal transclival approach allows a unique trajectory into the midline clivus and skull base that is unachievable from traditional craniotomy approaches to lesions such as chondrosarcomas, chordomas, and posterior fossa meningiomas. In this review, we will assess the benefits and drawbacks to using an endoscopic endonasal approach versus transcranial approach to these challenging lesions, assess the anatomical limits of endoscopic endonasal transclival surgery, and discuss the published literature on the topic...
June 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29520496/endoscopic-transnasal-surgery-of-clival-lesions-our-experience
#15
Daniele Marchioni, Angelo Musumeci, Cristoforo Fabbris, Stefano De Rossi, Davide Soloperto
BACKGROUND: The clivus is a region characterized by complex anatomy, with vascular and neural structures that are located in close proximity. Different pathologies can affect this area, and traditional surgical approaches were open approaches. Recently, the endoscopic transnasal technique has been introduced, and currently represents a good alternative for the surgical management of these lesions. This is a preliminary report on patients treated endoscopically for clival lesions by the authors' Skull Base Team...
May 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29510265/marked-effectiveness-of-low-dose-oral-methotrexate-for-steroid-resistant-idiopathic-hypertrophic-pachymeningitis-case-report
#16
Hiroki Uchida, Yoshikazu Ogawa, Teiji Tominaga
Idiopathic hypertrophic pachymeningitis (HP) is a rare clinical entity characterized by thickening of the dura mater without obvious underlying disease. High-dose steroid therapy is considered to be the first line for idiopathic HP, but half of patients show resistance for steroid therapy and suffer progressive clinical course. We describe low-dose methotrexate (MTX) administration for recurrent and steroid-resistant idiopathic HP resulting in noticeable improvement without severe adverse effects. A 51-year-old Japanese woman with dermatomyositis first presented with right retro-orbital pain caused by dural thickening in the sella and upper clivus involving the right trigeminal nerve, which was diagnosed as idiopathic HP by transsphenoidal biopsy...
May 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29499591/letter-to-the-editor-regarding-endoscopic-submandibular-retropharyngeal-approach-to-the-craniocervical-junction-and-clivus-an-anatomic-study
#17
LETTER
Y R Yadav, Vijay S Parihar, Shailendra Ratre
No abstract text is available yet for this article.
March 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29499424/transnasal-endoscopic-and-lateral-approaches-to-the-clivus-a-quantitative-anatomic-study
#18
Francesco Doglietto, Marco Ferrari, Davide Mattavelli, Francesco Belotti, Vittorio Rampinelli, Hussein Kheshaifati, Davide Lancini, Alberto Schreiber, Tommaso Sorrentino, Marco Ravanelli, Barbara Buffoli, Lena Hirtler, Roberto Maroldi, Piero Nicolai, Luigi Fabrizio Rodella, Marco Maria Fontanella
BACKGROUND: Transnasal endoscopic approaches to the clivus have been established recently. Comparative analyses with classic lateral approaches are limited. In this study, we compared transnasal endoscopic and lateral approaches to the clivus, quantifying the exposure and working volume of each approach in the anatomy laboratory. METHODS: High-resolution computed tomography scans were performed on 5 injected specimens (10 sides). In each specimen, transnasal endoscopic approaches (i...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29483606/clinicopathologic-characteristics-of-poorly-differentiated-chordoma
#19
Angela R Shih, Gregory M Cote, Ivan Chebib, Edwin Choy, Thomas DeLaney, Vikram Deshpande, Francis J Hornicek, Ruoyu Miao, Joseph H Schwab, G Petur Nielsen, Yen-Lin Chen
Chordoma is a rare malignant tumor of bone with high morbidity and mortality. Recently, aggressive pediatric poorly differentiated chordoma with SMARCB1 loss has been described. This study summarizes the clinicopathologic features of poorly differentiated chordoma with SMARCB1 loss in the largest series to date. A search of records between 1990-2017 at MGH identified 19 patients with poorly differentiated chordoma. Immunohistochemical stains were evaluated. Kaplan-Meier survival statistics and log-rank (Mantel Cox) tests compared survival with other subtypes...
February 26, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29478095/-the-pen-is-mightier-than-the-sword-suicidal-trans-orbital-intracranial-penetrating-injury-from-a-pencil
#20
Danica Cvetković, Vladimir Živković, Irina Damjanjuk, Slobodan Nikolić
A 40-year-old drug addict, who was being treated with methadone and occupational therapy, committed suicide by striking a wooden pencil into his right eye socket. While still conscious, he hit his head hard against a table, jamming the pencil even deeper into his head. The autopsy showed that the pencil missed the globe and lodged in the inner part of the right eye socket. It pierced the orbital part of the right ethmoid bone, the right ethmoid cells, and the right superior nasal concha, then passed through the body of the sphenoid bone and the clivus of the occipital bone before stopping in the brain tissue...
February 24, 2018: Forensic Science, Medicine, and Pathology
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