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https://www.readbyqxmd.com/read/29053075/machine-learning-applied-to-neuroimaging-for-diagnosis-of-adult-classic-chiari-malformation-role-of-the-basion-as-a-key-morphometric-indicator
#1
Aintzane Urbizu, Bryn A Martin, Dulce Moncho, Alex Rovira, Maria A Poca, Juan Sahuquillo, Alfons Macaya, Malena I Español
OBJECTIVE The current diagnostic criterion for Chiari malformation Type I (CM-I), based on tonsillar herniation (TH), includes a diversity of patients with amygdalar descent that may be caused by a variety of factors. In contrast, patients presenting with an overcrowded posterior cranial fossa, a key characteristic of the disease, may remain misdiagnosed if they have little or no TH. The objective of the present study was to use machine-learning classification methods to identify morphometric measures that help discern patients with classic CM-I to improve diagnosis and treatment and provide insight into the etiology of the disease...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29050071/-poorly-differentiated-chordoma-with-ini1-loss-a-clinicopathologic-study
#2
J Y Feng, L Chen, Y Y Ma, H W Yang, L Chen
Objective: To analyze the clinicopathologic characteristics of poorly-differentiated chordoma with INI1 loss in children and to discuss the differential diagnosis. Methods: The clinical, radiological, histopathological profiles and molecular pathologic characteristics of two pediatric poorly differentiated chordoma cases with INI1 loss were reviewed. Results: The patients were a girl and a boy. Both lesions involved the slope. Both patients were presented with progressive muscle weakness or neck pain. Radiological examination showed clivus bone destruction and compression of the brain stem and cervical spinal cord...
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28983379/hypoglossal-nerve-mononeuropathy-as-the-first-presenting-symptom-of-progressing-multiple-myeloma
#3
Neil B Newman, Vidya Puthenpura, Stephanie Mischell, Gabriela Ferreira
Multiple myeloma (MM) rarely presents with a primary neurological dysfunction, and if it does it is usually due to a plasmacytoma. This is the first case to discuss hypoglossal nerve dysfunction as the first sign of MM progression secondary to severe pathophysiologic bone lysis. A PubMed-based literature search was completed on April 17, 2016 for the terms "multiple myeloma" and "hypoglossal nerve neuropathy". A 73-year-old woman with known MM who received little treatment for several years, presented secondary to dysarthria and at first was thought to have hyperviscosity syndrome...
February 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/28961728/combined-endoscopic-endonasal-and-transoral-surgery-for-a-chordoma-in-the-whole-clivus-with-marked-caudal-extension
#4
Takuma Hara, Hiroyoshi Akutsu, Tetsuya Yamamoto, Shuho Tanaka, Muneyoshi Yasuda, Shingo Takano, Hiroyoshi Kino, Hidetaka Miyamoto, Akira Matsumura
No abstract text is available yet for this article.
August 5, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28942017/first-report-of-renal-cell-carcinoma-metastasizing-to-the-clivus-in-a-paediatric-patient
#5
Lebohang Modikeng, John R Ouma, Reena Mohanlal
The clivus is a rare site of tumour occurrence in general, and metastases to this site are especially rare.(1) Renal cell carcinoma is an uncommon entity in the paediatric population. While not infrequent in adults, when it does occur metastases to the clivus are extremely uncommon, only having been reported thrice in the literature. All cases involved adults in their sixth decade.(1-4).
September 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28926835/air-in-the-subdural-space-at-the-clivus
#6
Mustafa Ogden, Mehmet Faik Özveren
No abstract text is available yet for this article.
September 20, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28914866/-extended-endoscopic-endonasal-posterior-transclival-approach-to-tumors-of-the-clival-region-and-ventral-posterior-cranial-fossa-part-1-topographic-and-anatomical-features-of-the-clivus-and-adjacent-structures
#7
A N Shkarubo, K V Koval', G F Dobrovol'skiy, M A Shkarubo, V V Karnaukhov, B A Kadashev, D N Andreev, I V Chernov, O A Gadzhieva, O Yu Aleshkina, E A Anisimova, P L Kalinin, M A Kutin, D V Fomichev, O I Sharipov, D B Ismailov, E S Selivanov
OBJECTIVE: to describe the main topographic and anatomical features of the clival region and its adjacent structures for improvement and optimization of the extended endoscopic endonasal posterior (transclival) approach for resection of tumors of the clival region and ventral posterior cranial fossa. MATERIAL AND METHODS: We performed a craniometric study of 125 human skulls and a topographic anatomical study of heads of 25 cadavers, the arterial and venous bed of which was stained with colored silicone (the staining technique was developed by the authors) to visualize bed features and individual variability...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28904574/multicentric-chordoma-in-a-child
#8
Shighakolli Ramesh, Raju Subodh, Srinadh Boppana, Erukkambattu Jayashankar
Chordomas are primary malignant bone tumors that arise in the axial skeleton, believed to originate from remnants of embryologic notochordal cell rests. Multicentric origin of chordoma is extremely rare. To our literature search, we found only three cases of multicentric chordoma in adults. We report a first case of multicentric chordoma in pediatric age group. A 14-month-old child presented with torticolis and left upper limb monoparesis, imaging showed expansile bony destructive lesion in clivus and dorsal spine simultaneously...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28899547/linear-dimensions-of-normal-upper-airway-structure-by-magnetic-resonance-imaging-in-chinese-han-infants-and-preschool-children
#9
Xiaoli Yi, Linyin Yao, Xinyu Yuan, Yongxiang Wei, Zhenchang Wang
OBJECTIVES: To establish normative data of upper airway structure in Chinese Han infants and preschool children. METHODS: Magnetic resonance imaging (MRI) scans of 521 Chinese Han infants and preschool children (225 girls, 296 boys) aged from 1 day to 72 months were selected from the children who underwent head MRI at the Capital Institute of Pediatrics Affiliated Children Hospital, Beijing, China. No subjects had sleep-disordered breathing or associated conditions that may have affected the upper airway anatomy...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28883763/cyberknife-stereotactic-radiosurgery-and-denosumab-for-giant-cell-tumour-of-the-skull-base-case-report
#10
Cuauhtemoc de la Peña, Jorge H Guajardo, Maria F Gonzalez, Miguel A Hinojosa, Erick Cardona
Giant cell tumours (GCT) of the skull is a rare entity with only small number of cases reported in literature and optimal treatment is yet to be determined. These tumours have shown high recurrence rates after incomplete surgery, usually occurring during the first year. Even with new surgical techniques a complete resection in skull base tumours is not always possible without functional compromise. Therefore, adjuvant therapy is essential to enhance local control and quality of life. We report a rare case of a 34-year-old male with giant cell tumour (GCT) of the skull base involving the petrous bone, clivus and sphenoid body...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28869136/basilar-artery-dolichoectasia-prevalence-and-correlates-with-markers-of-cerebral-small-vessel-disease-in-community-dwelling-older-adults
#11
Oscar H Del Brutto, Robertino M Mera, Victor J Del Brutto, Aldo F Costa, Mauricio Zambrano, James Brorson
BACKGROUND: Basilar artery (BA) dolichoectasia has been associated with cerebral small vessel disease (SVD). However, studies have focused on stroke patients, and results cannot be extrapolated to the population at large. In this study, we aimed to assess prevalence of BA dolichoectasia and its association with SVD in community-dwelling older adults living in rural Ecuador. METHODS: Atahualpa residents aged ≥60 years underwent brain magnetic resonance imaging and magnetic resonance angiography of intracranial vessels...
August 28, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28868044/merkel-cell-carcinoma-with-distant-metastasis-to-the-clivus-causing-symptoms-mimicking-tolosa-hunt-syndrome-a-case-report-and-literature-review
#12
Kwo Wei David Ho, Peter A Drew, Miguel Chuquilin
Merkel cell carcinoma (MCC) is an uncommon but highly malignant neuroendocrine tumor of the skin. MCC can metastasize, but involvement of the central nervous system is rare. Here, we report a case of rapidly progressing metastatic MCC to the clivus and bilateral cavernous sinus in an immunocompromised patient. This case is unique in that it is the first case report showing MCC metastasis to the clivus from a distant site. It also demonstrates that a MCC metastasis can masquerade with symptoms of Tolosa-Hunt syndrome...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28862040/lymphoplasmacyte-rich-meningioma-with-atypical-angiomatous-feature-and-an-increased-deposition-of-igg4-positive-plasma-cells-an-unusual-case-report
#13
Hyun-Jin Son, In Kyu Yu, Seong Min Kim
Lymphoplasmacyte-rich meningioma (LPRM) is an extremely rare variant of meningioma, and a small percentage of LPRM may be associated with IgG4-related disease. To date, the coexistence of 2 rare meningioma variants consisting of LPRM and angiomatous meningioma within one neoplasm has not been reported in the literature. A 56-year-old woman presented with episodes of frequent and severe epistaxis that began 4 months ago. Initial magnetic resonance imaging showed localized, heterogeneous, and intermediate to high signal lesion at the odontoid process and clivus...
August 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28838112/endoscopic-endonasal-surgery-for-cranial-base-chondrosarcomas
#14
Francisco Vaz-Guimaraes, Juan C Fernandez-Miranda, Maria Koutourousiou, Ronald L Hamilton, Eric W Wang, Carl H Snyderman, Paul A Gardner
BACKGROUND: Microsurgical resection via open approaches is considered the main treatment modality for cranial base chondrosarcomas (CBCs). The use of endoscopic endonasal approaches (EEAs) has been rarely reported. OBJECTIVE: To present the endoscopic endonasal experience with CBCs at our institution. METHODS: Retrospective review of the medical records of 35 consecutive patients who underwent EEA for CBC resection between January 2004 and April 2013...
August 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28831279/setup-uncertainties-and-ptv-margins-at-different-anatomical-levels-in-intensity-modulated-radiotherapy-for-nasopharyngeal-cancer
#15
Milan Anjanappa, Malu Rafi, Saju Bhasi, Rejnish Kumar, Kainickal Cessal Thommachan, Tapesh Bhattacharya, Kunnambath Ramadas
AIM: To determine the systematic error (∑), random error (σ) and derive PTV margin at different levels of the target volumes in Nasopharyngeal Cancer (NPC). MATERIALS AND METHODS: A retrospective offline review was done for patients who underwent IMRT for NPC from June 2015 to May 2016 at our institution. Alternate day kV images were matched with digitally reconstructed radiographs to know the setup errors. All radiographs were matched at three levels - the clivus, third cervical (C3) and sixth cervical (C6) vertebra...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28826656/a-morphometric-assessment-of-type-i-chiari-malformation-above-the-mcrae-line-a-retrospective-case-control-study-in-302-adult-female-subjects
#16
James R Houston, Maggie S Eppelheimer, Soroush Heidari Pahlavian, Dipankar Biswas, Aintzane Urbizu, Bryn A Martin, Jayapalli Rajiv Bapuraj, Mark Luciano, Philip A Allen, Francis Loth
PURPOSE: Type I Chiari malformation (CMI) is a radiologically-defined structural dysmorphism of the hindbrain and posterior cranial fossa (PCF). Traditional radiographic identification of CMI relies on the measurement of the cerebellar tonsils in relation to the foramen magnum with or without associated abnormalities of the neuraxis. The primary goal of this retrospective study was to comprehensively assess morphometric parameters above the McRea line in a group of female CMI patients and normal controls...
August 18, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28819680/quantitative-approach-to-the-posterior-cranial-fossa-and-craniocervical-junction-in-asymptomatic-children-with-achondroplasia
#17
Rosalinda Calandrelli, Marco Panfili, Gabriella D'Apolito, Giuseppe Zampino, Alessandro Pedicelli, Fabio Pilato, Cesare Colosimo
PURPOSE: We propose an magnetic resonance imaging (MRI)-based quantitative morphovolumetric approach to the posterior cranial fossa (PCF) and craniocervical junction (CCJ) changes in achondroplastic patients investigating possible associations with ventriculomegaly and medullary compression. METHODS: We analyzed MRI of 13 achondroplastic children not treated by surgery. 3D FSPGR T1-weighted images were used to analyze (1) PCF synchondroses; (2) PCF volume (PCFV), PCF brain volume (PCFBV), PCFV/PCFBV ratio, cerebellar volume, cerebrospinal fluid (CSF) spaces volume, and IV ventricle volume; (3) PCF (clivus, supraocciput, exocciput lengths, tentorial angle) and CCJ (AP and LL diameters of foramen magnum (FM)) morphometry; (4) measurements of FM and jugular foramina (JF) areas; and (5) supratentorial ventricular volume...
August 17, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28768673/insidious-enemy-downside-to-prolonged-survival-in-prostate-cancer
#18
Vaishali Lodhia, Thevamalar Puspanathan
An 83-year-old man, a prostate cancer survivor of 10 years with multiple vertebral metastases presented with sudden onset of double vision. On examination he was found to have an isolated partial left abducens palsy with no other neurological deficits. Despite having microvascular risk factors, given his history of prostate cancer, aMRI brain scan was requested to look for a neurological cause. The scan revealed a metastatic lesion in the clivus encasing the cavernous sinus and carotid artery. He was referred to his oncologist for further management, however he opted out of further treatment and succumbed to his illness a month later...
August 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28761547/plasmacytoma-of-the-clivus
#19
R Amita, S Sandhyamani, Suresh Nair, T R Kapilamoorthy
We report a case of solitary plasmacytoma of the clivus in a 55 year old male.
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28752203/treatment-of-atlanto-axial-subluxation-secondary-to-rheumatoid-arthritis-by-short-segment-stabilization-with-polyaxial-screws
#20
Petr Vanek, Ondrej Bradac, Patricia de Lacy, Karel Pavelka, Martina Votavova, Vladimir Benes
OBJECTIVE: The main aim of this study was to analyse the compex clinical and radiographic findings in a group of RA patients with atlanto-axial slip (AAS) treated with free-hand short C1 lateral mass and C2 trans-pedicular screw fixation. The surgical technique used and the pathology treated were the same in all patients, producing a very homogeneous cohort of patients This allowed the study and measurement of radiographic parameters and fusion process. METHODS: Twenty-nine patients (21 female, 8 male, mean age 54...
July 27, 2017: Acta Neurochirurgica
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