keyword
MENU ▼
Read by QxMD icon Read
search

Oxygen

keyword
https://www.readbyqxmd.com/read/29471531/carbon-monoxide-poisoning-in-wood-pellet-storerooms
#1
N Golob, D Grenc, M Brvar
Background: Carbon monoxide is the leading cause of mortality from unintentional poisoning in Slovenia. It has been shown that carbon monoxide levels can rise in wood pellet storerooms because of chemical degradation of pellets, even at room temperature. We present a case of lethal carbon monoxide poisoning with first responder carbon monoxide exposure. Aims: To highlight the dangers rescuers face during interventions in pellet storerooms and the need for preventive precautions...
February 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29471490/pharmacologic-assessment-of-bovine-ruminal-and-mesenteric-vascular-serotonin-receptor-populations
#2
M A Snider, D L Harmon, J L Klotz
Prior work using a contractility bioassay determined that the serotonin (5-HT) receptor subtype 5-HT2A is present in bovine lateral saphenous veins and plays a role in ergot alkaloid-induced vascular contraction in steers grazing endophyte-infected (Epichloë coenophiala) tall fescue (Lolium arundinaceum). Ergot alkaloids have also been shown to be vasoactive in bovine gut vasculature. To determine what 5-HT receptors are involved in vasoconstriction of gut vasculature, contractility of ruminal and mesenteric arteries and veins collected from cattle were evaluated in the presence of agonists selective for 5-HT1B (CP 93129) 5-HT1D (L-694, 247), 5-HT2A (TCB-2), 5-HT2B (BW 723C86), 5-HT4 (BIMU-8) and 5-HT7 (LP 44) receptors...
February 17, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471244/two-sesquiterpene-aminoquinones-protect-against-oxidative-injury-in-hacat-keratinocytes-via-activation-of-ampk%C3%AE-erk-nrf2-are-ho-1-signaling
#3
Li Liu, Wei Wu, Jing Li, Wei-Hua Jiao, Li-Yun Liu, Jie Tang, Lei Liu, Fan Sun, Bing-Nan Han, Hou-Wen Lin
AIMS: To investigate the cytoprotective effects of two sesquiterpene aminoquinones isolated from the marine sponge Dysidea fragilis, Dysidaminone H (DA8) and 3'-methylamino-avarone (DA14), we examined their effects against hydrogen peroxide (H2 O2 )-induced oxidative injury in human keratinocyte cell line and elucidated the underlying mechanisms. MAIN METHODS: Cell viability was detected using a CCK-8 assay kit. Intracellular reactive oxygen species (ROS) production was measured by fluorescence of 2, 7-Dichlorodi-hydrofluorescein diacetate (DCFH-DA)...
February 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29471123/gold-iii-bis-thiosemicarbazonate-compounds-in-breast-cancer-cells-cytotoxicity-and-thioredoxin-reductase-targeting
#4
Vanessa Rodríguez-Fanjul, Elena López-Torres, M Antonia Mendiola, Ana María Pizarro
Gold(III) compounds have received increasing attention in cancer research. Three gold complexes of general formula [AuIII L]Cl, where L is benzil bis(thiosemicarbazonate), compound 1, benzil bis(4-methyl-3-thiosemicarbazonate), compound 2, or benzil bis(4-cyclohexyl-3-thiosemicarbazonate), compound 3, have been synthesized and fully characterized, including the X-ray crystal structure of compound 3, confirming square-planar geometry around the gold(III) centre. Compound 1 showed moderate cytotoxicity and accumulation in MCF7 breast cancer cells but did not inhibit thioredoxin reductase (TrxR) activity and did not induce reactive oxygen species (ROS) production...
February 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29471108/redox-stress-in-marfan-syndrome-dissecting-the-role-of-the-nadph-oxidase-nox4-in-aortic-aneurysm
#5
Francesc Jiménez-Altayó, Thayna Meirelles, Eva Crosas-Molist, M Alba Sorolla, Darya Gorbenko Del Blanco, Judit López-Luque, Aleksandra Mas-Stachurska, Ana-Maria Siegert, Fabio Bonorino, Laura Barberà, Carolina García, Enric Condom, Marta Sitges, Fernando Rodríguez-Pascual, Francisco Laurindo, Katrin Schröder, Joaquim Ros, Isabel Fabregat, Gustavo Egea
Marfan syndrome (MFS) is characterized by the formation of ascending aortic aneurysms resulting from altered assembly of extracellular matrix fibrillin-containing microfibrils and dysfunction of TGF-β signaling. Here we identify the molecular targets of redox stress in aortic aneurysms from MFS patients, and investigate the role of NOX4, whose expression is strongly induced by TGF-β, in aneurysm formation and progression in a murine model of MFS. Working models included aortae and cultured vascular smooth muscle cells (VSMC) from MFS patients, and a NOX4-deficient Marfan mouse model (Fbn1C1039G/+ -Nox4-/- )...
February 19, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29471107/pick1-deficiency-exacerbates-sepsis-associated-acute-lung-injury-and-impairs-glutathione-synthesis-via-reduction-of-xct
#6
Meizi Qian, Yingying Lou, Yixiu Wang, Minyuan Zhang, Qun Jiang, Yunchang Mo, Kunyuan Han, Shenhui Jin, Qinxue Dai, Yulong Yu, Zhen Wang, Junlu Wang
The role of oxidative stress has been well documented in the development of sepsis-induced acute lung injury (ALI). Protein interaction with C-kinase 1 (PICK1) participates in oxidative stress-related neuronal diseases. However, its function in lung infections and inflammatory diseases is not known. We therefore sought to investigate whether PICK1 is involved in sepsis-induced ALI. Cecal ligation and puncture (CLP) was performed in anesthetized wild type (WT) and PICK1 knock out (KO, PICK1-/- ) mice with C57BL/6 background...
February 19, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29471067/the-smell-of-renal-protection-against-chronic-kidney-disease-hydrogen-sulfide-offers-a-potential-stinky-remedy
#7
REVIEW
George J Dugbartey
Chronic kidney disease (CKD) is a common global health challenge characterized by irreversible pathological processes that reduce kidney function and culminates in development of end-stage renal disease. It is associated with increased morbidity and mortality in addition to increased caregiver burden and higher financial cost. A central player in CKD pathogenesis and progression is renal hypoxia. Renal hypoxia stimulates induction of oxidative and endoplasmic reticulum stress, inflammation and tubulointerstitial fibrosis, which in turn, promote cellular susceptibility and further aggravate hypoxia, thus forming a pathological vicious cycle in CKD progression...
October 19, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29471056/number-of-raised-steps-during-the-short-and-fast-step-test-a-functional-tool-to-assess-response-to-brief-and-intense-effort-involving-anaerobic-metabolism
#8
Davy Laroche, Morgane Mangin, Delphine Besson, Alexandre Naaim, Anaïs Gouteron, Jean-Marie Casillas
BACKGROUND: Although the initial anaerobic component of exercise adaptation is unavoidable, no specific functional test is available for use in routine non-sporting practice to evaluate it. OBJECTIVE: To assess the bioenergetic and biomechanical properties of the Short and Fast Step Test (SFST), which consists of walking up and down a step as many times as possible in 1minute and to analyse its ability to explore the initial anaerobic component of effort in comparison to a reference self-paced step test...
February 19, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29471006/astilbin-ameliorates-cisplatin-induced-nephrotoxicity-through-reducing-oxidative-stress-and-inflammation
#9
Si-Wei Wang, Yi Xu, Yuan-Yuan Weng, Xue-Yu Fan, Yong-Feng Bai, Xiao-Yan Zheng, Li-Jun Lou, Feng Zhang
Oxidative stress and inflammation are considered to be the main pathogenesis of cisplatin nephrotoxicity. Astilbin, a flavonoid with anti-oxidation and anti-inflammation function, has been used to treat heavy metal induced kidney injury. In this study, we investigated the protective effects of astilbin on cisplatin-induced nephrotoxicity and its underlying mechanisms. Our results showed that astilbin markedly inhibited cisplatin-induced cell apoptosis and recovered cell growth. Astilbin significantly decreased reactive oxygen species (ROS) accumulation and alleviated ROS-induced activation of p53, MAPKs and AKT signaling cascades, which in turn attenuated cisplatin-induced HEK-293 cell apoptosis...
February 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29470954/the-optical-properties-of-rat-porcine-and-human-lenses-in-organ-culture-treated-with-dexamethasone
#10
Mark Bree, Douglas Borchman
Organ culturing of lenses is useful for testing the direct effect of moieties such as cations, glucose, oxygen, antioxidants or drugs on the lens. Lens opacity changes in organ cultured lenses have never been measured quantitatively. Our aims were twofold: to establish the time course of lens opacity changes in organ cultured rat, porcine and human lenses and to test the utility of our system to measure opacity changes in lenses treated with dexamethasone. Human, porcine and rat lenses were incubated with or without 5 μM dexamethasone in minimum essential medium for 13 days...
February 19, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29470849/direct-integration-of-red-nir-emissive-ceramic-like-anm6xi8xa6-metal-cluster-salts-in-organic-copolymers-using-supramolecular-interactions
#11
Yann Molard, Malo Robin, Noée Dumait, Maria Amela-Cortes, Claire Roiland, Maxime Harnois, Emmanuel Jacques, Hervé Folliot
Hybrid nanomaterials made of inorganic nanocomponents dispersed in an organic host raise an increasing interest as low-cost solution-processable functional materials. However, preventing phase segregation while allowing a high inorganic doping content remains a major challenge, and usual methods require a functionalization step prior integration. Herein, we report a new approach to design such nanocomposite in which lead-free and cadmium-free ceramic-like metallic nanocluster compounds are embedded at 10 wt % in organic copolymers, without any functionalization...
February 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29470843/polycarboxyl-decorated-fe-iii-based-xerogel-derived-multifunctional-efficient-electrode-material-for-oxygen-reduction-reaction-and-supercapacitor-application
#12
Bandhana Devi, M Venkateswarulu, Himmat Kushwaha, Aditi Halder, Rik Koner
Low cost, non-noble metal catalyst with good oxygen reduction reaction (ORR) activity comparable to that of platinum and having good energy storage properties is highly desirable but challenging. Several challenges are associated with the development of such materials. Herein, we demonstrate a new polycarboxyl functionalized Fe (III) based gel material, synthesized following solvothermal method and the development of its composite (Fe3O4/Fe/C) by annealing at optimised temperature. The developed composite displayed excellent electrocatalytic activity for oxygen reduction reaction (ORR) with onset potential of 0...
February 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29470719/seasonal-and-spatial-variation-of-reservoir-water-quality-in-the-southwest-of-ethiopia
#13
Bizuneh Woldeab, Abebe Beyene, Argaw Ambelu, Ishi Buffam, Seid Tiku Mereta
This research investigated the spatiotemporal variation of water quality in the Gilgel Gibe reservoir, Ethiopia, using physicochemical water quality parameters. Nonparametric tests and multivariate statistical techniques were used to evaluate data sets measured during dry and rainy seasons. Electrical conductivity (EC), pH, biochemical oxygen demand (BOD5 ), total phosphorus (TP), total nitrogen (TN), nitrate (NO3 - ), total dissolved solids (TDSs), and total suspended solids (TSSs) were all significantly different among seasons (Mann-Whitney U test, p < 0...
February 22, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29470708/the-wound-response-in-fresh-cut-lettuce-involves-programmed-cell-death-events
#14
Elena T Iakimova, Ernst J Woltering
In this work, the involvement of programmed cell death (PCD) in the wound-induced postharvest browning disorder and senescence in butterhead lettuce (Lactuca sativa L.) fresh-cuts was studied. At the wounded (cut, bruised) sites, rapid browning, loss of chlorophyll and massive cell death, accompanied with accumulation of reactive oxygen species and increased electrolyte leakage occurred in a narrow strip of tissue adjacent the injury. The dead cell morphology (protoplast and nuclei shrinkage) together with the biochemical and physiological changes resembled necrotic PCD type...
February 22, 2018: Protoplasma
https://www.readbyqxmd.com/read/29470646/reactive-oxygen-radicals-and-gaseous-transmitters-in-carotid-body-activation-by-intermittent-hypoxia
#15
REVIEW
Nanduri R Prabhakar, Ying-Jie Peng, Guoxiang Yuan, Jayasri Nanduri
Sleep apnea is a prevalent respiratory disease characterized by periodic cessation of breathing during sleep causing intermittent hypoxia (IH). Sleep apnea patients and rodents exposed to IH exhibit elevated sympathetic nerve activity and hypertension. A heightened carotid body (CB) chemoreflex has been implicated in causing autonomic abnormalities in IH-treated rodents and in sleep apnea patients. The purpose of this article is to review the emerging evidence showing that interactions between reactive oxygen species (ROS) and gaseous transmitters as a mechanism cause hyperactive CB by IH...
February 22, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29470503/sevoflurane-posttreatment-prevents-oxidative-and-inflammatory-injury-in-ventilator-induced-lung-injury
#16
Julie Wagner, Karl M Strosing, Sashko G Spassov, Ziwei Lin, Helen Engelstaedter, Sabine Tacke, Alexander Hoetzel, Simone Faller
Mechanical ventilation is a life-saving clinical treatment but it can induce or aggravate lung injury. New therapeutic strategies, aimed at reducing the negative effects of mechanical ventilation such as excessive production of reactive oxygen species, release of pro-inflammatory cytokines, and transmigration as well as activation of neutrophil cells, are needed to improve the clinical outcome of ventilated patients. Though the inhaled anesthetic sevoflurane is known to exert organ-protective effects, little is known about the potential of sevoflurane therapy in ventilator-induced lung injury...
2018: PloS One
https://www.readbyqxmd.com/read/29470455/urban-rural-county-and-state-differences-in-chronic-obstructive-pulmonary-disease-united-states-2015
#17
Janet B Croft, Anne G Wheaton, Yong Liu, Fang Xu, Hua Lu, Kevin A Matthews, Timothy J Cunningham, Yan Wang, James B Holt
Chronic obstructive pulmonary disease (COPD) accounts for the majority of deaths from chronic lower respiratory diseases, the third leading cause of death in the United States in 2015 and the fourth leading cause in 2016.* Major risk factors include tobacco exposure, occupational and environmental exposures, respiratory infections, and genetics.† State variations in COPD outcomes (1) suggest that it might be more common in states with large rural areas. To assess urban-rural variations in COPD prevalence, hospitalizations, and mortality; obtain county-level estimates; and update state-level variations in COPD measures, CDC analyzed 2015 data from the Behavioral Risk Factor Surveillance System (BRFSS), Medicare hospital records, and death certificate data from the National Vital Statistics System (NVSS)...
February 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29470439/study-of-hexane-adsorption-on-activated-carbons-with-differences-in-their-surface-chemistry
#18
Diana Hernández-Monje, Liliana Giraldo, Juan Carlos Moreno-Piraján
The study of aliphatic compounds adsorption on activated carbon can be carried out from the energetic change involved in the interaction; the energy values can be determined from isotherms or by the immersion enthalpy. Vapor phase adsorption isotherms of hexane at 263 K on five activated carbons with different content of oxygenated groups and the immersion enthalpy of the activated carbons in hexane and water were determined in order to characterize the interactions in the solid-liquid system, and for calculating the hydrophobic factor of the activated carbons...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29470431/articular-cartilage-aging-potential-regenerative-capacities-of-cell-manipulation-and-stem-cell-therapy
#19
REVIEW
Magdalena Krajewska-Włodarczyk, Agnieszka Owczarczyk-Saczonek, Waldemar Placek, Adam Osowski, Joanna Wojtkiewicz
Changes in articular cartilage during the aging process are a stage of natural changes in the human body. Old age is the major risk factor for osteoarthritis but the disease does not have to be an inevitable consequence of aging. Chondrocytes are particularly prone to developing age-related changes. Changes in articular cartilage that take place in the course of aging include the acquisition of the senescence-associated secretory phenotype by chondrocytes, a decrease in the sensitivity of chondrocytes to growth factors, a destructive effect of chronic production of reactive oxygen species and the accumulation of the glycation end products...
February 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29470419/nanotherapy-and-reactive-oxygen-species-ros-in-cancer-a-novel-perspective
#20
Peter Brenneisen, Andreas S Reichert
The incidence of numerous types of cancer has been increasing over recent years, representing the second-most frequent cause of death after cardiovascular diseases. Even though, the number of effective anticancer drugs is increasing as well, a large number of patients suffer from severe side effects (e.g., cardiomyopathies) caused by these drugs. This adversely affects the patients' well-being and quality of life. On the molecular level, tumor cells that survive treatment modalities can become chemotherapy-resistant...
February 22, 2018: Antioxidants (Basel, Switzerland)
keyword
keyword
2925
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"