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https://www.readbyqxmd.com/read/29245136/small-maf-functions-in-the-maintenance-of-germline-stem-cells-in-the-drosophila-testis
#1
Sharon Wui Sing Tan, George W Yip, Toshio Suda, Gyeong Hun Baeg
Reactive oxygen species (ROS) are byproducts generated during normal cellular metabolism, and redox states have been shown to influence stem cell self-renewal and lineage commitment across phyla. However, the downstream effectors of ROS signaling that control stem cell behavior remain largely unexplored. Here, we used the Drosophila testis as an in vivo model to identify ROS-induced effectors that are involved in the differentiation process of germline stem cells (GSCs). In the Affymetrix microarray analysis, 152 genes were either upregulated or downregulated during GSC differentiation induced by elevated levels of ROS, and a follow-up validation of the gene expression by qRT-PCR showed a Spearman's rho of 0...
December 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/29245086/liquid-chromatography-tandem-mass-spectrometric-assay-for-the-quantitation-of-the-novel-radiation-protective-agent-and-radiation-mitigator-jp4-039-in-murine-plasma
#2
Susan Christner, Jianxia Guo, Robert A Parise, Melanie Ringeval, Adam T Hoye, Peter Wipf, Michael W Epperly, Joel S Greenberger, Jan H Beumer, Julie L Eiseman
JP4-039 radio-protects prior to, and radio-mitigates after ionizing radiation by neutralizing reactive oxygen species. We developed and validated an LC-MS/MS assay for the quantitation of JP4-039 in murine plasma. Methanol protein precipitation of 50μL plasma was followed by isocratic reverse phase chromatography for a 6min run time, and electrospray positive mode ionization mass spectrometric detection. The plasma assay was linear from 1 to 1000ng/mL with appropriate accuracy (97.1-107.6%) and precision (3...
December 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29245060/activation-of-human-eosinophils-with-palladium-nanoparticles-pd-nps-importance-of-the-actin-cytoskeleton-in-pd-nps-induced-cellular-adhesion
#3
P Chhay, M Murphy-Marion, Y Samson, D Girard
Palladium (Pd) is known to be released into the environment in the fine and ultrafine (at the nanoscale) airborne particle fractions mainly from automobile catalytic converters leading to an increase human exposure to this noble metal. It was reported that Pd can induce allergic reactions in individuals exposed to it via different ways. Some studies reported an increased number of eosinophils into airways following NP exposure in vivo in rodent models of allergies and inflammation. Knowing the importance of eosinophils in allergies, asthma and other lung diseases, it is surprising to observe that the direct effect of Pd at the nanoscale in eosinophils has been poorly documented...
December 11, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29245041/stability-of-postmortem-methemoglobin-artifactual-changes-caused-by-storage-conditions
#4
Vincent Varlet, Elenore Ryser, Marc Augsburger, Cristian Palmiere
Hemoglobin is the protein in red blood cells that carries and distributes oxygen to the body. Methemoglobinemia is a blood disorder in which an abnormal amount of methemoglobin (MetHb), a form of hemoglobin (Hb), is produced from either inadequate MetHb reductase activity or too much MetHb production or by exposure to oxidizing agents. This could lead to anoxia and death if it is not treated. However, this parameter has not been investigated as a valid post-mortem indicator because random MetHb levels have been observed in various studies: MetHb increases can be observed due to autoxidation during storage, and MetHb decreases can be observed due to MetHb reductase or microbial activity in post-mortem samples...
December 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29245036/inhibition-of-microbial-fuel-cell-operation-for-municipal-wastewater-treatment-by-impact-loads-of-free-ammonia-in-bench-and-45l-scale
#5
Heinz Hiegemann, Manfred Lübken, Patrick Schulte, Karl-Georg Schmelz, Sylvia Gredigk-Hoffmann, Marc Wichern
A 45-liter microbial fuel cell (MFC) system was integrated into a full-scale wastewater treatment plant (WWTP). The system was operated under practical conditions with supernatant of a pre-thickener for 50days in order to identify, whether higher power output and energy recovery is possible compared to the use of primary clarifier effluent, as used in a previous study. The higher COD (chemical oxygen demand) loading rates of supernatant neither increased power densities, nor energy recovery, but impact loads of total ammonia nitrogen (TAN) in concentrations >800mg/L (free ammonia nitrogen (FAN)>40mg/L) led to an instant collapse of power output and nutrient removal, which was reversed when ammonia concentrations decreased...
December 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29244947/a-new-strategy-for-in-vitro-determination-of-carbonic-anhydrase-activity-from-analysis-of-oxygen-18-isotopes-of-co2
#6
Chiranjit Ghosh, Santanu Mandal, Mithun Pal, Manik Pradhan
The oxygen-18 isotopic (18O) composition in CO2 provides important insight into the variation of rate in isotopic fractionation reaction regulated by carbonic anydrase (CA) metalloenzyme. This work aims to employ 18O-isotope ratio-based analytical method for quantitative estimation of CA activity in erythrocytes for clinical testing purposes. Here, a new method has been developed that contains the measurements of 18O/16Oisotope ratios during oxygen-18 isotopic exchange between 12C16O16O and H218O of in-vitro biochemical reaction controlled by erythrocytes CA and estimation of enzymatic activity of CA from the isotopic composition of CO2...
December 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29244897/new-electrode-and-electrolyte-configurations-for-lithium-oxygen-battery
#7
Ulderico Ulissi, Giuseppe Antonio Elia, Sangsik Jeong, Jakub Reiter, Nikolaos Tsiouvaras, Stefano Passerini, Jusef Hassoun
We report herein cathode configurations alternative to the most diffused ones for application in lithium-oxygen batteries using an ionic liquid-based electrolyte. The electrodes employ high surface area conductive carbon as the reaction host and polytetrafluoroethylene as the binding agent to enhance ORR/OER reversibility. Roll-pressed, self-standing electrodes (SSEs) and thinner, spray deposited electrodes (SDEs) are characterized in lithium-oxygen cells using an ionic liquid (IL) based electrolyte formed by mixing lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) salt in N,N-diethyl-N-(2-methoxyethyl)-N-methylammonium bis(trifluoromethanesulfonyl)imide (DEMETFSI)...
December 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29244876/water-quality-assessment-of-australian-ports-using-water-quality-evaluation-indices
#8
Sayka Jahan, Vladimir Strezov
Australian ports serve diverse and extensive activities, such as shipping, tourism and fisheries, which may all impact the quality of port water. In this work water quality monitoring at different ports using a range of water quality evaluation indices was applied to assess the port water quality. Seawater samples at 30 stations in the year 2016-2017 from six ports in NSW, Australia, namely Port Jackson, Botany, Kembla, Newcastle, Yamba and Eden, were investigated to determine the physicochemical and biological variables that affect the port water quality...
2017: PloS One
https://www.readbyqxmd.com/read/29244828/involvement-of-phenoloxidase-in-browning-during-grinding-of-tenebrio-molitor-larvae
#9
Renske H Janssen, Catriona M M Lakemond, Vincenzo Fogliano, Giovanni Renzone, Andrea Scaloni, Jean-Paul Vincken
Insects are investigated as alternative protein source to meet the increasing demand for proteins in the future. Enzymatic browning occurring during grinding of insect and subsequent extraction of proteins can influence the proteins' properties, but it is unclear which enzymes are responsible for this phenomenon. This study was performed on larvae of three commonly used insect species, namely Tenebrio molitor, Alphitobius diaperinus and Hermetia illucens. Oxygen consumption measurements on protein extracts showed activity on L-tyrosine, L-3,4-di-hydroxy-phenylalanine (L-DOPA) and L-dopamine, indicating phenoloxidase as a key player in browning...
2017: PloS One
https://www.readbyqxmd.com/read/29244788/dual-modulation-of-human-hepatic-zonation-via-canonical-and-non-canonical-wnt-pathways
#10
Laura McEnerney, Kara Duncan, Bo-Ram Bang, Sandra Elmasry, Meng Li, Toshio Miki, Sadeesh K Ramakrishnan, Yatrik M Shah, Takeshi Saito
The hepatic lobule is divided into three zones along the portal-central vein axis. Hepatocytes within each zone exhibit a distinctive gene expression profile that coordinates their metabolic compartmentalization. The zone-dependent heterogeneity of hepatocytes has been hypothesized to result from the differential degree of exposure to oxygen, nutrition and gut-derived toxins. In addition, the gradient of Wnt signaling that increases towards the central vein seen in rodent models is believed to play a critical role in shaping zonation...
December 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29244744/a-carbon-dioxide-limitation-inducible-protein-cola-supports-the-growth-of-synechococcus-sp-pcc-7002
#11
Ginga Shimakawa, Satoru Watanabe, Chikahiro Miyake
A limitation in carbon dioxide (CO₂), which occurs as a result of natural environmental variation, suppresses photosynthesis and has the potential to cause photo-oxidative damage to photosynthetic cells. Oxygenic phototrophs have strategies to alleviate photo-oxidative damage to allow life in present atmospheric CO₂ conditions. However, the mechanisms for CO₂ limitation acclimation are diverse among the various oxygenic phototrophs, and many mechanisms remain to be discovered. In this study, we found that the gene encoding a CO₂ limitation-inducible protein, ColA, is required for the cyanobacterium Synechococcus sp...
December 15, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29244655/duplex-imprinted-nano-well-arrays-for-promising-nanoparticles-assembly
#12
Xiangping Li, Andreas Manz
A large area nano-duplex-imprint technique is presented in this contribution using natural cicada wings as stamp. The glassy wings of the cicada, which are abundant in nature, exhibit strikingly interesting nanopillar structures over their membrane. This technique, with excellent performance despite the nonplanar surface of the wings, combines the top-down and bottom-up nanofabrication techniques. It transits micro-nanofabrication from cleanroom environment to bench. Two different materials - dicing tape with acrylic layer and UV optical adhesive - are used to make replications at the same time, thus achieving duplex imprint...
December 15, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29244520/enantioselective-total-synthesis-of-cannogenol-3-o-%C3%AE-l-rhamnoside-via-sequential-cu-ii-catalyzed-michael-addition-intramolecular-aldol-cyclization-reactions
#13
Bijay Bhattarai, Pavel Nagorny
A concise and scalable enantioselective total synthesis of the natural cardenolides cannogenol and cannogenol-3-O-α-l-rhamnoside has been achieved in 18 linear steps. The synthesis features a Cu(II)-catalyzed enantioselective and diastereoselective Michael reaction/tandem aldol cyclization and a one-pot reduction/transposition, which resulted in a rapid (6 linear steps) assembly of a functionalized intermediate containing C19 oxygenation that could be elaborated to cardenolide cannogenol. In addition, a strategy for achieving regio- and stereoselective glycosylation at the C3 position of synthetic cannogenol was developed and applied to the preparation of cannogenol-3-O-α-l-rhamnoside...
December 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/29244506/synthesis-of-double-bond-substituted-hemithioindigo-photoswitches
#14
Aaron Gerwien, Till Reinhardt, Peter Mayer, Henry Dube
A very short, high yielding, and convergent synthesis with broad substrate scope, enabling access to a very diverse range of hemithioindigos with 4-fold substituted double-bonds, is presented. With this method, carbon as well as nitrogen, oxygen, or sulfur based substituents can easily be introduced, delivering a wide array of novel structural motifs. Irradiation studies with visible light demonstrate proficient photoswitching properties of these chromophores at wavelengths up to 625 nm.
December 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/29244491/surface-cluster-catalyst-for-n2-to-nh3-thermal-conversion
#15
Xue-Lu Ma, Jin-Cheng Liu, Hai Xiao, Jun Li
The ammonia synthesis from N2 is of vital importance, with imitating biological nitrogen fixation attracted much interest. Herein, we investigate the catalytic mechanisms of N2-to-NH3 thermal conversion on the singly dispersed bimetallic catalyst Rh1Co3/CoO(011), and find that the preferred pathway is an associative mechanism analogous to the biological process, in which alternating hydrogenations of the N2 occur, with H2 activation on both metal sites. We propose that the singly dispersed bimetallic M1An catalyst, in which the doped metal atom M substitutes an oxygen atom on the oxide surface of metal A, serves as a new surface single-cluster catalyst (SCC) design platform for the biomimetic N2-to-NH3 thermal conversion...
December 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29244196/iron-overload-induces-g1-phase-arrest-and-autophagy-in-murine-preosteoblast-cells
#16
Wan-Jing Cen, Yi Feng, Shu-Shu Li, Wei-Liang Huang, Tao Zhang, Wu Zhang, Wei-Dong Kong, Jian-Wei Jiang
This study aimed to investigate the cell cycle arrest and autophagy induced by iron overload inMC3T3-E1 cells. MC3T3-E1 cells were cultured in different concentrations of ferric ammonium citrate (FAC), and Perls' Prussian blue reaction was used to detect the iron levels of the cells. CCK-8 assays were used to detect the growth of MC3T3-E1. The level of reactive oxygen species (ROS) within cells was investigated with DCFH-DA. PI staining was used to analyze the cell cycle distribution of MC3T3-E1 cells. Finally, the expression levels of cell cycle related proteins, autophagy related proteins, AKT, p38 MAPK, Stat3 and their downstream proteins were detected with western blot assays...
December 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29244159/pre-clinical-model-of-severe-glutathione-peroxidase-3-deficiency-and-chronic-kidney-disease-results-in-coronary-artery-thrombosis-and-depressed-left-ventricular-function
#17
Paul Pang, Molly Abbott, Malyun Abdi, Quynh-Anh Fucci, Nikita Chauhan, Murti Mistri, Brandon Proctor, Matthew Chin, Bin Wang, Wenqing Yin, Tzong-Shi Lu, Arvin Halim, Kenneth Lim, Diane E Handy, Joseph Loscalzo, Andrew M Siedlecki
Background: Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3). We hypothesized that GPx3 deficiency may lead to cardiovascular disease in the presence of chronic kidney disease due to an accumulation of reactive oxygen species and decreased microvascular perfusion of the myocardium. Methods: To isolate the exclusive effect of GPx3 deficiency in kidney disease-induced cardiac disease, we studied the GPx3 knockout mouse strain (GPx3-/-) in the setting of surgery-induced CKD...
December 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29243970/reactive-oxygen-species-damage-drives-cardiac-and-mitochondrial-dysfunction-following-acute-nano-titanium-dioxide-inhalation-exposure
#18
Cody E Nichols, Danielle L Shepherd, Quincy A Hathaway, Andrya J Durr, Dharendra Thapa, Alaeddin Abukabda, Jinghai Yi, Timothy R Nurkiewicz, John M Hollander
Nanotechnology offers innovation in products from cosmetics to drug delivery, leading to increased engineered nanomaterial (ENM) exposure. Unfortunately, health impacts of ENM are not fully realized. Titanium dioxide (TiO2) is among the most widely produced ENM due to its use in numerous applications. Extrapulmonary effects following pulmonary exposure have been identified and may involve reactive oxygen species (ROS). The goal of this study was to determine the extent of ROS involvement on cardiac function and the mitochondrion following nano-TiO2 exposure...
December 15, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29243969/low-molecular-weight-oligonol-a-polyphenol-derived-from-lychee-fruit-attenuates-experimental-reflux-esophagitis-and-hcl-ethanol-induced-gastric-ulcer
#19
Seong-Soo Roh, Mi-Rae Shin, Sung Ho Shin, Joo Young Lee, Yeong Ok Song, Minji Woo, Kap-Seop Jeong, Jeong Sook Noh
Oligonol, a polyphenol derived from lychee fruit, is produced by an oligomerization process that converts high-molecular-weight polyphenol polymers into low-molecular-weight oligomers. Evidence suggests that oligonol exerts its beneficial effects based on antioxidant and anti-inflammatory properties. This study was the first to investigate the antioxidative and anti-inflammatory effects of oligonol on gastroesophageal inflammatory models: surgically induced acute reflux esophagitis (RE) and gastric ulcer (GU) induced by HCl/ethanol...
December 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29243919/zinc-ii-metalated-porphyrins-as-photothermogenic-photosensitizers-for-cancer-photodynamic-photothermal-synergistic-therapy
#20
Kaikai Ding, Ye-Wei Zhang, Weili Si, Xiangmin Zhong, Yu Cai, Jianhua Zou, Jinjun Shao, Zhou Yang, Xiaochen Dong
Porphyrin derivatives are the first-generation photosensitizers, and to design a strong NIR-absorbing porphyrin with good water solubility is highly desired for better therapeutic effect to treat tumors. Herein, three new porphyrin derivatives, 5,10,15,20-tetrakis(3,4- dimethoxyphenyl) porphyrin (P1), 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) Zinc porphyrin (ZnP1), and 5,15-bis (3,4-dimethoxyphenyl)-10,20-bis ((4-methoxyphenyl)ethynyl) Zinc porphyrin (ZnP2) have been synthesized. Among them, ZnP2 shows the longest and most intensive Q-bands in the near-infrared (NIR) region, as endows it the strongest light-harvesting capability and deepest tumor tissue penetration...
December 15, 2017: ACS Applied Materials & Interfaces
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