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Priscila Ferreira Batista, Alan Carlos Costa, Caroline Müller, Robson de Oliveira Silva-Filho, Fábia Barbosa da Silva, Andrew Merchant, Giselle Camargo Mendes, Kelly Juliane Telles Nascimento
Crambe abyssinica is widely cultivated in the off-season in the Midwest region of Brazil with great potential for biodeisel production. Low precipitation is characteristic of this region, which can drastically affect the productivity of C. abyssinica. Signaling molecules, such as nitric oxide (NO), can potentially alleviate the effects of water stress on plants. Here we test whether nitric oxide, applied by donor sodium nitroprusside (SNP), can alleviate the occurrence of water deficit damages in Crambe plants and maintain physiological and biochemical processes...
June 12, 2018: Plant Physiology and Biochemistry: PPB
Young-Mee Kim, Seock-Won Youn, Varadarajan Sudhahar, Archita Das, Reyhaan Chandhri, Henar Cuervo Grajal, Junghun Kweon, Silvia Leanhart, Lianying He, Peter T Toth, Jan Kitajewski, Jalees Rehman, Yisang Yoon, Jaehyung Cho, Tohru Fukai, Masuko Ushio-Fukai
Mitochondrial dynamics are tightly controlled by fusion and fission, and their dysregulation and excess reactive oxygen species (ROS) contribute to endothelial cell (EC) dysfunction. How redox signals regulate coupling between mitochondrial dynamics and endothelial (dys)function remains unknown. Here, we identify protein disulfide isomerase A1 (PDIA1) as a thiol reductase for the mitochondrial fission protein Drp1. A biotin-labeled Cys-OH trapping probe and rescue experiments reveal that PDIA1 depletion in ECs induces sulfenylation of Drp1 at Cys644 , promoting mitochondrial fragmentation and ROS elevation without inducing ER stress, which drives EC senescence...
June 19, 2018: Cell Reports
Kyoung Eun Lee, Michelle Spata, Richard Maduka, Robert H Vonderheide, M Celeste Simon
Pancreatitis is an inflammatory disease of the exocrine pancreas and ranks among the most common gastrointestinal disorders. Inflamed tissues frequently experience conditions of insufficient oxygen availability, or hypoxia. Here, we demonstrate that hypoxia and consequent stabilization of the hypoxia-inducible factor 1α (HIF1α) transcription factor occur in murine and human pancreatitis. Mice lacking pancreas-specific HIF1α expression display markedly impaired pancreatic regeneration following cerulein-induced pancreatitis, which is associated with excessive intrapancreatic B cell accumulation...
June 19, 2018: Cell Reports
Elvan Yilmaz, David Bier, Xavier Guillory, Jeroen Briels, Yasser Ruiz-Blanco, Elsa Sanchez-Garcia, Christian Ottmann, Markus Kaiser
Previous studies have indicated the presence of defined interactions between oligo or poly(ethylene glycol) (OEG or PEG) and lysine residues. In these interactions, the OEG or PEG residues 'wrap around' the lysine amino group, thereby enabling complexation of the amino group by the ether oxygen residues. The resulting biochemical binding affinity and thus biological relevance of this supramolecular interaction however remains unclear so far. Here, we report that OEG-containing phosphophenol ether inhibitors of 14-3-3 proteins also display such a 'lysine-wrapping' binding mode...
June 20, 2018: Chemistry: a European Journal
R E Kalinin, I A Suchkov, R V Deev, N D Mzhavanadze, A A Krylov
Analysed in the article are the results of a comprehensive approach to treatment of patients presenting with lower limb critical ischaemia and diabetes mellitus by means of gene-induced angiogenesis. The study comprised a total of 65 patients found to have an ill-suited for surgical reconstruction peripheral arterial bed and undergoing conservative therapy. The patients were divided into two groups. The Study Group patients additionally to the conventional conservative therapy received 2 intramuscular injections of therapeutic agent Neovasculgen at a course dose of 2...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Kung-Ha Choi, Mi Hwa Park, Hyun Ah Lee, Ji-Sook Han
Exposure to high levels of glucose may cause glucotoxicity, leading to pancreatic β cell dysfunction, including cell apoptosis and impaired glucose-stimulated insulin secretion. The aim of this study was to explore the effect of cyanidin-3-rutinoside (C3R), a derivative of anthocyanin, on glucotoxicity-induced apoptosis in INS-1 pancreatic β cells. Glucose (30 mM) treatment induced INS-1 pancreatic β cell death, but glucotoxicity and apoptosis significantly decreased in cells treated with 50 μM C3R compared to that observed in 30 mM glucose-treated cells...
June 20, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
Ashley Hesson, Elizabeth Langen
OBJECTIVE: Early-onset oligohydramnios is typically secondary to renal-urinary anomalies (RUA) or preterm premature rupture of membranes (PPROM). We compared neonatal pulmonary outcomes between these etiologies. METHODS: We conducted a retrospective cohort study of women with oligohydramnios identified before 24 completed weeks of gestation attributed to either PPROM or RUA. Patients were excluded if other fetal anomalies were noted. Respiratory morbidity was assessed by the need for oxygen at 36 corrected weeks or at hospital discharge...
June 20, 2018: Journal of Perinatal Medicine
Alibek Abdrakhmanov, Andrey V Kulikov, Ekaterina A Luchkina, Boris Zhivotovsky, Vladimir Gogvadze
Mitophagy, the selective degradation of mitochondria via the autophagic pathway, is a vital mechanism of mitochondrial quality control in cells. The removal of malfunctioning or damaged mitochondria is essential for normal cellular physiology and tissue development. Stimulation of mitochondrial permeabilization and release of proapoptotic factors from the intermembrane space is an essential step in triggering the mitochondrial pathway of cell death. In this study, we analyzed the extent to which mitophagy interferes with cell death, attenuating the efficiency of cancer therapy...
June 1, 2018: Biological Chemistry
Joshua Good, Eric Viana, Kirsten A Burgomaster, Shilpa Dogra
The purpose was to compare the airway response to sprint interval exercise (SIE) and continuous exercise (CE) in active adults with exercise-induced bronchoconstriction (EIBC), and to compare ventilatory and oxygen delivery responses between adults with and without EIBC. Adults with EIBC (n = 8, 22.3 ± 3.0 years) and adults without EIBC (n = 8, 22.3 ± 3.0 years) completed a SIE (4 × 30 s sprints separated by 4.5 min of active recovery) and CE (20 min at 65% peak power output) session. Lung function was assessed at baseline, during exercise, and up to 20 min post-exercise...
June 20, 2018: Journal of Sports Sciences
Diogo F M Santos, Olívia S G P Soares, José L Figueiredo, Manuel Fernando R Pereira
Cryptomelane-type manganese oxides prepared by a solvent-free method were evaluated as catalysts for the oxidation of ethyl acetate, ethanol and toluene. The original catalyst (K-OMS-2) presented high catalytic activity for ethyl acetate and ethanol oxidation, achieving 90% conversion into CO2 around 200 °C for both pollutants. Toluene was much harder to oxidize, requiring a temperature near 270 °C for the same conversion. The original catalyst was mechanically treated in a ball mill at different intensities, in order to decrease the particle size for subsequent impregnation onto structured supports, as small particle sizes are usually recommended...
June 20, 2018: Environmental Technology
Jenny Lundeberg, John R Feiner, Andrew Schober, Jeffrey W Sall, Helge Eilers, Philip E Bickler
Lundeberg, Jenny, John R. Feiner, Andrew Schober, Jeffrey W. Sall, Helge Eilers, and Philip E. Bickler. Increased cytokines at high altitude: lack of effect of ibuprofen on acute mountain sickness, physiological variables or cytokine levels. High Alt Med Biol. 00:000-000, 2018. INTRODUCTION: There is no consensus on the role of inflammation in high-altitude acclimatization. AIMS: To determine the effects of a nonsteroidal anti-inflammatory drug (ibuprofen 400 mg every 8 hours) on blood cytokines, acclimatization, acute mountain sickness (AMS, Lake Louise Score), and noninvasive oxygenation in brain and muscle in healthy volunteers...
June 20, 2018: High Altitude Medicine & Biology
Udita Brahmachari, Zhanjun Guo, Sara E Konecny, Emmanuela N C Obi, Bridgette A Barry
Photosystem II oxidizes water at a Mn4 CaO5 cluster. Oxygen evolution is accompanied by proton release through a 35 Å hydrogen-bonding network to the lumen. The mechanism of this proton-transfer reaction is not known, but the reaction is dependent on chloride. Here, vibrational spectroscopy defines the functional properties of the proton-transfer network using chloride, bromide, and nitrate as perturbative agents. As assessed by peptide C═O frequencies, bromide substitution yields a spectral Stark shift because of its increase in ionic radius...
June 20, 2018: Journal of Physical Chemistry. B
Yecan Pi, Qi Shao, Xing Zhu, Xiaoqing Huang
The anodic oxygen evolution reaction (OER) is central to various energy conversion devices, but the investigation of the dynamic evolution of catalysts in different OER conditions remains quite limited, which is unfavorable for the understanding of the actual structure-activity relationship and catalyst optimization. Herein, we constructed monodispersed IrNix nanoparticles (NPs) with distinct composition-segregated features and captured their structural evolution in various OER environments. We decoded the interesting self-reconstruction of IrNix NPs during the OER, in which an Ir-skin framework is generated in an acidic electrolyte, while a Ni-rich surface layer is observed in an alkaline electrolyte owing to Ni migration...
June 20, 2018: ACS Nano
Ruquan Ye, Dustin K James, James M Tour
Research on graphene abounds, from fundamental science to device applications. In pursuit of complementary morphologies, formation of graphene foams is often preferred over the native two-dimensional (2D) forms due to the higher available area. Graphene foams have been successfully prepared by several routes including chemical vapor deposition (CVD) methods and by wet-chemical approaches. For these methods, one often needs either high temperature furnaces and highly pure gases or large amounts of strong acids and oxidants...
June 20, 2018: Accounts of Chemical Research
Siew Yin Chan, Shermin S Goh, Qingqing Dou, Benjamin Qi Yu Chan, Wee Sim Choo, David James Young, Xian Jun Loh
Dilute acid polymerizes degassed, aqueous acrylamide with concomitant gelation, without the need for added free radical initiator or cross-linking agent. This reaction is accelerated by sonication or UV irradiation, but inhibited by adventitious oxygen or the addition of a free radical inhibitor, suggesting an acid-accelerated free radical process. The resulting hydrogels are thixotropic in nature and partially disrupted by the addition of chaotropic agents, indicating the importance of hydrogen bonding to the 3D network...
June 20, 2018: Chemistry, An Asian Journal
Eva E Buschmann, Philipp Hillmeister, Anja Bondke Persson, David S Liebeskind, Lea Schlich, Robert Kamenzky, Andreas Busjahn, Ivo R Buschmann, Peter Bramlage, Andreas Hetzel, Matthias Reinhard
BACKGROUND: External counterpulsation improves cerebral perfusion velocity in acute stroke and may stimulate collateral artery growth. However, whether (non-acute) at-risk patients with high-grade carotid artery disease may benefit from counterpulsation needs to be validated. METHODS: Twenty-eight patients (71±6.5 years, 5 women) with asymptomatic unilateral chronic severe ICA stenosis (>70%) or occlusion were randomized to receive 20 min active counterpulsation followed by sham treatment or vice versa...
June 20, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Adauto Tsutomu Ikejiri, Frederico Somaio Neto, Paulo Roberto Bertoletto, José Carlos Chaves, Alexandre Key WakateTeruya, Cândida Aparecida Leite Kassuya, Murched Omar Taha, Djalma José Fagundes
PURPOSE: To evaluate the effect of hyperbaric oxygenation (HBO) on the expression of the genes antioxidant glutathione peroxidase 4 (Gpx4) and lactoperoxidase (Lpo) in the lung of mice subjected to intestinal ischemia and reperfusion (IIR). METHODS: Control group (CG) in which were subjected to anesthesia, laparotomy and observation for 120 minutes; an ischemia and reperfusion group (IRG) subjected to anesthesia, laparotomy, small bowel ischemia for 60 minutes and reperfusion for 60 minutes; and three groups treated with HBO during ischemia (HBOG + I), during reperfusion (HBOG + R) and during ischemia and reperfusion (HBOG + IR)...
May 2018: Acta Cirúrgica Brasileira
Zhanqi Zhao, Chan-Ching Chu, Mei-Yun Chang, Hao-Tai Chang, Yeong-Long Hsu
RATIONALE: Methylmalonic acidemia (MMA) is an autosomal recessive disease of organic acidemia. PATIENT CONCERNS: We report a 26-year-old male who presented with metabolic acidosis, acute renal failure required hemodialysis and acute respiratory failure required mechanical ventilation support. Progressive hypotonia of muscles made weaning from mechanical ventilator difficult. DIAGNOSES: High level of serum methylmalonic acid and the mut genotype sequences confirmed the diagnosis of this adult-onset MMA...
June 2018: Medicine (Baltimore)
Masaru Kobayashi, Shinya Fukuda, Ken-Ichi Takano, Junji Kamizono, Kotaro Ichikawa
To determine whether a peripheral capillary oxygen saturation (SpO2) of 95% to 96% should be considered "nonurgent" in school-aged children, as suggested by the Canadian Emergency Department Triage and Acuity Scale.School-aged children (6-12 years old) with a normal body temperature (36.5-37.4°C) who visited our department between September, 2014 and August, 2015 (n = 4556) were divided into 4 groups based on SpO2: group A: 99% to 100%; group B: 97% to 98%; group C: 95% to 96%; and group D: ≤94%...
June 2018: Medicine (Baltimore)
Zhengfeng Gu, Lian Xin, Zhiping Wang, Jun Wang
INTRODUCTION: Congenital heart disease and pulmonary arterial hypertension are perilous to a gravida for the high morbidity and mortality. CASE PRESENTATION: We report an extremely rare case of a 27-year-old gravida with congenital heart disease and severe pulmonary arterial hypertension of 115 mmHg. Arterial blood gas analysis revealed her oxygen saturation (SpO2) of 67.8% and oxygen partial pressure of 40.0 mmHg, which were severely low. The patient was diagnosed as having gestation combined with congenital heart disease, severe pulmonary arterial hypertension, and hypoxemia...
June 2018: Medicine (Baltimore)
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