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https://www.readbyqxmd.com/read/29687834/the-relationship-between-esophageal-cancer-chagasic-megaesophagus-and-hpv-myths-tales-or-reality
#1
REVIEW
Fernanda Franco Munari, Adriana Cruvinel Carloni, Vânia Sammartino Mariano, Kari Syrjanen, Rui Manuel Reis, Adhemar Longatto-Filho
A supposed role for persistent high-risk human papillomavirus (HPV) infection in esophageal squamous cell carcinoma (ESCC) etiology has been suggested by a number of studies. Concomitantly, megaesophagus induced by the Trypanosoma cruzi cell-cycle activity also shows a potential association with ESCC. This review discusses esophageal cancer and the potential association between chagasic megaesophagus and HPV as risk factors for ESCC development.
April 24, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29550999/evaluation-of-the-immunoreactivity-of-nerve-growth-factor-and-tropomyosin-receptor-kinase-a-in-the-esophagus-of-noninfected-and-infected-individuals-with-trypanosoma-cruzi
#2
Jacqueline Garcia Duarte, Rodolfo Duarte Nascimento, Patrícia Rocha Martins, Débora d'Ávila Reis
Megaesophagus is one of the major manifestations of the chronic phase of Chagas disease. Its primary symptom is generally dysphagia due to disturbance in the lower esophageal sphincter. Microscopically, the affected organ presents denervation, which has been considered as consequence of an inflammatory process that begins at the acute phase and persists in the chronic phase. Inflammatory infiltrates are composed of lymphocytes, macrophages, natural killer cells, mast cells, and eosinophils. In this study, we evaluated the immunoreactivity of nerve growth factor (NGF), and of its receptor tropomyosin receptor kinase A (TrkA), molecules that are well known for having a relevant role in neuroimmune communication in the gastrointestinal tract...
March 17, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29545782/regulatory-lymphoid-and-myeloid-cells-determine-the-cardiac-immunopathogenesis-of-trypanosoma-cruzi-infection
#3
REVIEW
Manuel Fresno, Núria Gironès
Chagas disease is a multisystemic disorder caused by the protozoan parasite Trypanosoma cruzi , which affects ~8 million people in Latin America, killing 7,000 people annually. Chagas disease is one of the main causes of death in the endemic area and the leading cause of infectious myocarditis in the world. T. cruzi infection induces two phases, acute and chronic, where the infection is initially asymptomatic and the majority of patients will remain clinically indeterminate for life. However, over a period of 10-30 years, ~30% of infected individuals will develop irreversible, potentially fatal cardiac syndromes (chronic chagasic cardiomyopathy [CCC]), and/or dilatation of the gastro-intestinal tract (megacolon or megaesophagus)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29517674/esophageal-transit-time-in-patients-with-chagasic-megaesophagus-lack-of-linear-correlation-between-dysphagia-and-grade-of-dilatation
#4
Paula Martins, Cid Sergio Ferreira, José Renan Cunha-Melo
The aim of this study was to determine the esophageal transit time in control individuals and in chagasic patients with or without megaesophagus.A total of 148 patients were allocated in 6 groups according to serological diagnostic of Chagas disease and the degree of esophageal dilatation: A, control healthy individuals (n = 34, 22.9%); B, indeterminate form (n = 23, 15.5%); C, megaesophagus I (n = 37, 25.0%); D, megaesophagus II (n = 19, 12.8%); E, megaesophagus III (n = 21, 14.2%); and F, megaesophagus IV (n = 14, 9...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29516006/myositis-ganglioneuritis-and-myocarditis-with-distinct-perifascicular-muscle-atrophy-in-a-2-year-old-male-boxer
#5
Paul M Rossman, Stephanie A Thomovsky, Ryan M Schafbuch, Ling T Guo, G D Shelton
A 2-year-old male, intact Boxer was referred for chronic diarrhea, hyporexia, labored breathing, weakness and elevated creatine kinase, and alanine aminotransferase activities. Initial examination and diagnostics revealed a peripheral nervous system neurolocalization, atrial premature complexes, and generalized megaesophagus. Progressive worsening of the dog's condition was noted after 36 h; the dog developed aspiration pneumonia, was febrile and oxygen dependent. The owners elected humane euthanasia. Immediately postmortem biopsies of the left cranial tibial and triceps muscles and the left peroneal nerve were obtained...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29089698/laparoscopic-heller-s-myotomy-for-achalasia-cardia-one-time-treatment-in-developing-countries
#6
Vishal Gupta, Hunaid Hatimi, Saket Kumar, Abhijit Chandra
Laparoscopic Heller's myotomy (LHM) and endoscopic balloon dilation are two main treatment modalities for achalasia cardia. The best treatment modality in Indian setting, however, is still unknown. Here, we present the early results of LHM in achalasia. Hospital data from January 2009 to October 2013 was analyzed. Preoperative assessment included Eckardt's scoring, esophagogastroduodenoscopy, barium swallow examination, and esophageal manometry. Thirty-five patients (19 males and 16 females, median age 31 years, range 12-65) underwent LHM with partial fundoplication (with intraoperative endoscopy)...
October 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28926464/zenker-diverticulum-in-systemic-sclerosis-related-achalasic-megaesophagus
#7
Francesca Ingegnoli, Tommaso Schioppo
No abstract text is available yet for this article.
December 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28730326/infectious-diseases-causing-autonomic-dysfunction
#8
REVIEW
Francisco Javier Carod-Artal
OBJECTIVES: To review infectious diseases that may cause autonomic dysfunction. METHODS: Review of published papers indexed in medline/embase. RESULTS: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Autonomic dysfunction is relatively common in HIV-infected patients and heart rate variability is reduced even in early stages of infection...
February 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28620185/c-abl-regulates-gastrointestinal-muscularis-propria-homeostasis-via-erks
#9
Jinnan Xiang, Yiqun Zhang, Dandan Bao, Na Cao, Xin Zhang, Ping Li, Shoutao Qiu, Jigang Guo, Dan He, Baojie Li, Liqing Yao, Huijuan Liu
The gastrointestinal tract is responsible for food digestion and absorption. The muscularis propria propels the foodstuff through the GI tract and defects in intestine motility may cause obstruction disorders. Our present genetic studies identified non-receptor tyrosine kinase c-Abl as an important regulator of the muscularis propria homeostasis and a risk factor for rectal prolapse. Mouse deficient for c-Abl showed defects in the muscularis propria of gastrointestinal tract and older c-Abl (-/-) mice developed megaesophagus and rectal prolapse...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28524628/myenteric-neuroprotective-role-of-aspirin-in-acute-and-chronic-experimental-infections-with-trypanosoma-cruzi
#10
J Y Oda, M O Belém, T M Carlos, R Gouveia, B F C Luchetti, N M Moreira, C L Massocatto, S M Araújo, D M G Sant Ana, N C Buttow, P Pinge-Filho, E J A Araújo
BACKGROUND: Experimental and clinical studies have shown that myenteric neuron cell death during infection with Trypanosoma cruzi mainly occurs in the esophagus and colon, resulting in megaesophagus and megacolon, respectively. Evidence suggests that the cyclooxygenase enzyme (COX) is involved in the T. cruzi invasion process. The use of low-dose aspirin (ASA), a COX-1/COX-2 inhibitor, has been shown to reduce infection with T. cruzi. Therefore, in this study, we evaluated the effects of treatment with low-dose ASA on myenteric colonic neurons during murine infection with T...
May 19, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28509648/video-assisted-extirpation-of-cranial-mediastinal-masses-in-dogs-18-cases-2009-2014
#11
MULTICENTER STUDY
Melissa A MacIver, J Brad Case, Eric L Monnet, Geraldine B Hunt, Philipp D Mayhew, Michelle L Oblak, Jeffrey J Runge, Ameet Singh, Daniel D Smeak, Michele A Steffey, Sarah E Boston
OBJECTIVE To characterize clinical findings, surgical procedures, complications, and outcomes in dogs undergoing extirpation of masses from the cranial mediastinum via video-assisted thoracic surgery (VATS) and establish preliminary guidelines for case selection when considering VATS for thymectomy in dogs. DESIGN Retrospective case series. ANIMALS 18 client-owned dogs that underwent extirpation of a cranial mediastinal mass by means of VATS at 5 academic referral hospitals from 2009 through 2014. PROCEDURES Medical records were reviewed and data extracted regarding signalment, clinical signs, physical examination findings, diagnostic imaging results, surgical approach and duration, cytologic and histologic examination results, complications, outcome, and cause of death, when applicable...
June 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28502864/chagas-disease-in-europe-a-review-for-the-internist-in-the-globalized-world
#12
REVIEW
Spinello Antinori, Laura Galimberti, Roberto Bianco, Romualdo Grande, Massimo Galli, Mario Corbellino
Chagas disease (CD) or American trypanosomiasis identified in 1909 by Carlos Chagas, has become over the last 40years a global health concern due to the huge migration flows from Latin America to Europe, United States, Canada and Japan. In Europe, most migrants from CD-endemic areas are concentrated in Spain, Italy, France, United Kingdom and Switzerland. Pooled seroprevalence studies conducted in Europe show an overall 4.2% prevalence, with the highest infection rates observed among individuals from Bolivia (18...
September 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28375484/mutational-profile-of-tp53-in-esophageal-squamous-cell-carcinoma-associated-with-chagasic-megaesophagus
#13
C F Lacerda, A Cruvinel-Carloni, A T Torres de Oliveira, C Scapulatempo-Neto, R V M López, E Crema, S J Adad, M A M Rodrigues, M A C A Henry, D P Guimarães, R M Reis
Chaga's disease is an important communicable neglected disease that is gaining wider attention due to its increasing incidence worldwide. Achalasia due to chagasic megaesophagus (CM), a complication of this disease, is a known-yet, poorly understood-etiological factor for esophageal squamous cell carcinoma (ESCC) development. In this study, we aimed to perform the analysis of TP53 mutations in a series of Brazilian patients with ESCC that developed in the context CM (ESCC/CM), and to compare with the TP53 mutation profile of patients with benign CM and patients with nonchagasic ESCC...
April 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28375440/high-resolution-manometry-findings-in-patients-with-achalasia-and-massive-dilated-megaesophagus
#14
M A Menezes, C Andolfi, F A M Herbella, M G Patti
Achalasia may present in a non-advanced or an advanced (end stage) stage based on the degree of esophageal dilatation. Manometric parameters and esophageal caliber may be prognostic for the outcome of treatment. The correlation between manometry and disease stage has not been yet fully studied. This study aims to describe high-resolution manometry findings in patients with achalasia and massive dilated megaesophagus. Eighteen patients (mean age 61 years, 55% females) with achalasia and massive dilated megaesophagus, as defined by a maximum esophageal dilatation >10 cm at the barium esophagram, were studied...
May 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28327800/trypanosoma-cruzi-i-genotype-among-isolates-from-patients-with-chronic-chagas-disease-followed-at-the-evandro-chagas-national-institute-of-infectious-diseases-fiocruz-brazil
#15
Tatiana da Silva Fonseca de Oliveira, Barbara Neves Dos Santos, Tainah Silva Galdino, Alejandro Marcel Hasslocher-Moreno, Otilio Machado Pereira Bastos, Maria Auxiliadora de Sousa
INTRODUCTION: Trypanosoma cruzi is the etiologic agent of Chagas disease in humans, mainly in Latin America. Trypanosome stocks were isolated by hemoculture from patients followed at Evandro Chagas National Institute of Infectious Diseases (FIOCRUZ) and studied using different approaches. METHODS: For species and genotype identification, the stocks were analyzed by parasitological techniques, polymerase chain reaction assays targeted to specific DNA sequences, isoenzyme patterns, besides sequencing of a polymorphic locus of TcSC5D gene (one stock)...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28285728/chagas-disease-an-important-cause-of-megaesophagus-in-latin-america
#16
Edson Marchiori, Bruno Hochhegger, Gláucia Zanetti
No abstract text is available yet for this article.
August 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28100930/radiological-findings-in-megaesophagus-secondary-to-chagas-disease-chest-x-ray-and-esophagogram
#17
Thiago Giansante Abud, Lucas Giansante Abud, Vanessa Sales Vilar, Denis Szejnfeld, Samuel Reibscheid
OBJECTIVE: To identify and classify the radiographic patterns of megaesophagus in Chagas disease, as seen on esophagograms and chest X-rays. MATERIALS AND METHODS: This was a prospective study of 35 patients diagnosed with esophageal disease via manometry. The changes found on esophagograms were stratified according to Rezende's classification, divided into four categories (grades I through IV) determined by the degree of dilatation and impairement of esophageal motility...
November 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27853047/long-term-management-of-a-dog-with-idiopathic-megaesophagus-and-recurrent-aspiration-pneumonia-by-use-of-an-indwelling-esophagostomy-tube-for-suction-of-esophageal-content-and-esophagogastric-tube-feeding
#18
Yuka Kanemoto, Kenjiro Fukushima, Hideyuki Kanemoto, Koichi Ohno, Hajime Tsujimoto
A 10-year-old neutered male Labrador Retriever dog was diagnosed with idiopathic megaesophagus. Despite receiving conventional treatments including elevated feeding, the dog showed repeated regurgitation and aspiration pneumonia, consequently developing weight loss and severe malnutrition. For the purpose of controlling regurgitation, an esophagostomy tube was placed for draining the esophageal fluid. Additionally, an esophagogastric tube was placed for nutritional support. After tube placement, the average frequency of regurgitation was reduced from 2...
January 24, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27714664/megaesophagus-in-an-elderly-man-with-achalasia-a-not-so-benign-condition
#19
Paolo Mazzola, Francesca Carissimi, Patrizia Floris, Francesca Pittella, Marianna Galeazzi, Daniela Moretti, Giuseppe Bellelli, Marco Dinelli, Giorgio Annoni
No abstract text is available yet for this article.
August 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27706452/early-and-late-assessment-of-esophagocardioplasty-in-the-surgical-treatment-of-advanced-recurrent-megaesophagus
#20
José Luis Braga de Aquino, Marcelo Manzano Said, Douglas Alexandre Rizzanti Pereira, Vânia Aparecida Leandro-Merhi, Paula Casals do Nascimento, Virgínia Vieitez Reis
Background: Since Chagas disease has esophageal manifestations with different degrees of involvement, the best surgical option is controversial, especially for patients with advanced chagasic megaesophagus and recurrent symptoms after previous treatment. Objective: To assess the early and late outcomes of esophagocardioplasty in a series of patients with advanced recurrent chagasic megaesophagus. Methods: This descriptive study included 19 older patients with recurrent megaesophagus grade III/IV and positive immunofluorescence for Chagas disease...
October 2016: Arquivos de Gastroenterologia
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