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Paolo Mazzola, Francesca Carissimi, Patrizia Floris, Francesca Pittella, Marianna Galeazzi, Daniela Moretti, Giuseppe Bellelli, Marco Dinelli, Giorgio Annoni
No abstract text is available yet for this article.
October 6, 2016: Aging Clinical and Experimental Research
José Luis Braga de Aquino, Marcelo Manzano Said, Douglas Alexandre Rizzanti Pereira, Vânia Aparecida Leandro-Merhi, Paula Casals do Nascimento, Virgínia Vieitez Reis
Background: Since Chagas disease has esophageal manifestations with different degrees of involvement, the best surgical option is controversial, especially for patients with advanced chagasic megaesophagus and recurrent symptoms after previous treatment. Objective: To assess the early and late outcomes of esophagocardioplasty in a series of patients with advanced recurrent chagasic megaesophagus. Methods: This descriptive study included 19 older patients with recurrent megaesophagus grade III/IV and positive immunofluorescence for Chagas disease...
October 2016: Arquivos de Gastroenterologia
Cheng Shen, Guowei Che
No abstract text is available yet for this article.
August 2016: Indian Journal of Surgery
Cássia Rubia Bernardo, Ana Vitória Silveira Camargo, Luís Sérgio Ronchi, Amanda Priscila de Oliveira, Eumildo de Campos Júnior, Aldenis Albaneze Borim, Cinara Cássia Brandão de Mattos, Reinaldo Bulgarelli Bestetti, Luiz Carlos de Mattos
Chagas disease, caused by Trypanosoma cruzi, can affect the heart, esophagus and colon. The reasons that some patients develop different clinical forms or remain asymptomatic are unclear. It is believed that tissue immunogenetic markers influence the tropism of T. cruzi for different organs. ABO, Secretor and Lewis histo-blood group systems express a variety of tissue carbohydrate antigens that influence the susceptibility or resistance to diseases. This study aimed to examine the association of ABO, secretor and Lewis histo-blood systems with the clinical forms of Chagas disease...
August 24, 2016: Infection, Genetics and Evolution
Maureen A Griffin, Jessie S Sutton, Geraldine B Hunt, Bruno H Pypendop, Philipp D Mayhew
OBJECTIVE: To report the use of low-pressure carbon dioxide insufflation during video-assisted thoracoscopic surgery for resection of a noninvasive thymoma in a cat with secondary myasthenia gravis. STUDY DESIGN: Clinical case report. ANIMAL: Client-owned cat. METHODS: An 11-year-old castrated male domestic shorthair cat was examined for generalized weakness, voice change, hypersalivation, hyporexia, vomiting, coughing, and gagging...
July 11, 2016: Veterinary Surgery: VS
Nilanjan Panda, Nitin Kumar Bansal, Mohon Narsimhan, Ramesh Ardhanari
The results of cardiomyotomy in patients of achalasic megaesophagus with axis deviation are not satisfactory. Usually, an esophagectomy is advocated. We describe the technical details and outcomes of laparoscopic esophagogastroplasty for end-stage achalasia. The patient had end-stage achalasia, characterized by tortuous megaesophagus with axis deviation. The surgery was performed in supine position using four abdominal ports. The steps included mobilization of the gastroesophageal junction and lower intrathoracic esophagus, straightening the pulled intrathoracic esophagus into the abdomen, and a side-side esophagogastroplasty using purple Endo GIA Articulating Tri-Staple load, two firings...
December 2015: Indian Journal of Surgery
Cléber de Mesquita Andrade, Antônia Cláudia Jácome da Câmara, Daniela Ferreira Nunes, Paulo Marcos da Matta Guedes, Wogelsanger Oliveira Pereira, Egler Chiari, Rosiane Viana Zuza Diniz, Lúcia Maria da Cunha Galvão
INTRODUCTION: This study evaluated the clinical forms and manifestation severities of Chagas disease among serologically reactive individuals from Western Rio Grande do Norte (Northeastern Brazil). METHODS: This cross-sectional study included 186 adults who were evaluated using electrocardiography, echocardiography, chest radiography, and contrast radiography of the esophagus and colon. A clinical-epidemiological questionnaire was also used. RESULTS: The indeterminate, cardiac, digestive, and cardiodigestive clinical forms of Chagas disease were diagnosed in 51...
November 2015: Revista da Sociedade Brasileira de Medicina Tropical
Chinemerem Okwara, David Cangemi
A 63-year-old man with a history of hypothyroidism presented with a 10-year history of dysphagia to solid foods and liquids. He had had worsening of his symptoms for 6 months before presentation, with an associated weight loss of 27 kg (60 lb). An anterior–posterior radiograph of the chest obtained..
December 17, 2015: New England Journal of Medicine
Celso de Castro Pochini, Danilo Gagliardi, Roberto Saad Júnior, Ruy França de Almeida, Paulo Roberto Corsi
OBJECTIVE: To analyze the late results of advanced Chagasic megaesophagus treatment by esophagectomy associated with the use of proton pump inhibitor (omeprazole) as for the incidence of esophagitis and Barrett's esophagus in the remaining stump. METHODS: We studied patients with advanced megaesophagus undergoing esophagectomy and transmediastinal esophagogastroplasty. Patients were divided into three groups: A (20) with esophageal replacement by full stomach, without the use of omeprazole; B (20) with esophageal replacement by full stomach, with omeprazole 40 mg/day introduced after the first postoperative endoscopy and maintained for six years; and C (30) with esophageal replacement by gastric tube with use of omeprazole...
September 2015: Revista do Colégio Brasileiro de Cirurgiões
Daisuke Chihara, Anthony I Romer, C Florian Bentzinger, Michael A Rudnicki, Robert S Krauss
BACKGROUND: The mammalian esophageal musculature is unique in that it makes a transition from smooth to skeletal muscle, with most of this process occurring after birth. In order to better understand the mechanisms that control esophageal musculature development, we investigated the roles in this process of the paired box transcription factor, PAX7, a principal regulator of skeletal myogenic progenitor cells. Previous studies showed that Pax7 is important for determining the esophageal muscle composition...
2015: Skeletal Muscle
Feng Lin, Chengwu Liu, Chenglin Guo, Lunxu Liu
No abstract text is available yet for this article.
November 2015: American Journal of Gastroenterology
Seydou Togo, Ouattara Moussa Abdoulaye, Li Xing, Yena Sadio
No abstract text is available yet for this article.
2015: Pan African Medical Journal
G Desuter, V Van Parijs, Q Gardiner
We present the case of a 79 year-old patient with megaesophagus and aphagia, who required percutaneous endoscopic gastrostomy (PEG) feeding. Megaesophagus was considered the sole cause of aphagia by the referring secondary hospital. Solid state sensor videofluoromanometry (VFM) showed a substantial decrease in manometric values within the hypopharynx along with good relaxation of the upper-esophageal sphincter (UES). This led to electromyography (EMG), which showed features compatible with the diagnosis of Myasthenia Gravis (MG)...
2015: B-ENT
Jeffrey D Stanaway, Gregory Roth
Chagas disease, caused by infection with the protozoa Trypanosoma cruzi is transmitted most often by Triatominae insect vectors, but also through blood transfusion, organ transplant, and congenital transmission. Between 5 and 18 million people are currently infected and the infection is estimated to cause more than 10,000 deaths annually. The disease has 3 phases: acute, indeterminate, and chronic. The acute phase immediately follows infection. It is typically asymptomatic but produces fever and malaise in up to 5% of people...
September 2015: Global Heart
Barbara Gandolfi, Robert A Grahn, Erica K Creighton, D Colette Williams, Peter J Dickinson, Beverly K Sturges, Ling T Guo, G Diane Shelton, Peter A J Leegwater, Maria Longeri, Richard Malik, Leslie A Lyons
Some Devon Rex and Sphynx cats have a variably progressive myopathy characterized by appendicular and axial muscle weakness, megaesophagus, pharyngeal weakness and fatigability with exercise. Muscle biopsies from affected cats demonstrated variable pathological changes ranging from dystrophic features to minimal abnormalities. Affected cats have exacerbation of weakness following anticholinesterase dosing, a clue that there is an underlying congenital myasthenic syndrome (CMS). A genome-wide association study and whole-genome sequencing suggested a causal variant for this entity was a c...
December 2015: Animal Genetics
Feng Lin, Chengwu Liu, Chenglin Guo, Lunxu Liu
No abstract text is available yet for this article.
September 2015: American Journal of Gastroenterology
D W Hague, H D Humphries, M A Mitchell, G D Shelton
BACKGROUND: Acquired myasthenia gravis (MG) in cats most commonly causes generalized weakness without megaesophagus and is more often associated with a cranial mediastinal mass, compared to dogs. HYPOTHESIS/OBJECTIVES: To extend the clinical findings described in the report of 2000 on MG in cats (J Am Vet Med Assoc 215:55-57). ANIMALS: Two hundred and thirty-five cats with MG. METHODS: Retrospective case study to evaluate the long-term outcome and incidence of spontaneous remission in myasthenic cats...
September 2015: Journal of Veterinary Internal Medicine
J Moritz Kaths, Daniel B Foltys, Uwe Scheuermann, Mari Strempel, Stefan Niebisch, Maren Ebert, Boris Jansen-Winkeln, Ines Gockel, Hauke Lang
INTRODUCTION: Achalasia is one of the most common causes of dysphagia. Typical symptoms include difficulties in controlling the swallowing process, regurgitation, weight loss, and chest pain. A megaesophagus rarely causes tracheal compression with consecutive acute dyspnea or similar respiratory symptoms. PRESENTATION OF CASE: A 23-year-old male patient presented with difficulties in swallowing, a consecutive massive weight loss over the past three years, and minor respiratory ailments...
2015: International Journal of Surgery Case Reports
Omar D Borjas-Almaguer, Emmanuel I González-Moreno, José A González-González, Diego Garcia-Compean, Matías Salinas-Chapa, Héctor J Maldonado-Garza
No abstract text is available yet for this article.
June 2015: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
M Ye, Q Zhang, X Xu, Q Zhang, Y Ge, P Geng, J Yan, L Luo, Y Sun, X Liang
Megaesophagus is a disease where peristalsis fails to occur properly and esophagus is enlarged. The etiology and mechanism of megaesophagus are not well understood. In this study, we reported that junctional adhesion molecule C (JAM-C) knockout mice on a C57/B6 background developed progressive megaesophagus from embryonic day (E) 15.5 onward with complete penetrance. JAM-C knockout mice exhibited a significant reduction in the number of nerve fibers/ganglia in the wall of the esophagus. However, histological analysis revealed that the esophageal wall thickness and structure of JAM-C knockout mice at embryonic stages and young adult were comparable to that of control littermates...
June 30, 2015: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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