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https://www.readbyqxmd.com/read/28620185/c-abl-regulates-gastrointestinal-muscularis-propria-homeostasis-via-erks
#1
Jinnan Xiang, Yiqun Zhang, Dandan Bao, Na Cao, Xin Zhang, Ping Li, Shoutao Qiu, Jigang Guo, Dan He, Baojie Li, Liqing Yao, Huijuan Liu
The gastrointestinal tract is responsible for food digestion and absorption. The muscularis propria propels the foodstuff through the GI tract and defects in intestine motility may cause obstruction disorders. Our present genetic studies identified non-receptor tyrosine kinase c-Abl as an important regulator of the muscularis propria homeostasis and a risk factor for rectal prolapse. Mouse deficient for c-Abl showed defects in the muscularis propria of gastrointestinal tract and older c-Abl (-/-) mice developed megaesophagus and rectal prolapse...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28524628/myenteric-neuroprotective-role-of-aspirin-in-acute-and-chronic-experimental-infections-with-trypanosoma-cruzi
#2
J Y Oda, M O Belém, T M Carlos, R Gouveia, B F C Luchetti, N M Moreira, C L Massocatto, S M Araújo, D M G Sant Ana, N C Buttow, P Pinge-Filho, E J A Araújo
BACKGROUND: Experimental and clinical studies have shown that myenteric neuron cell death during infection with Trypanosoma cruzi mainly occurs in the esophagus and colon, resulting in megaesophagus and megacolon, respectively. Evidence suggests that the cyclooxygenase enzyme (COX) is involved in the T. cruzi invasion process. The use of low-dose aspirin (ASA), a COX-1/COX-2 inhibitor, has been shown to reduce infection with T. cruzi. Therefore, in this study, we evaluated the effects of treatment with low-dose ASA on myenteric colonic neurons during murine infection with T...
May 19, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28509648/video-assisted-extirpation-of-cranial-mediastinal-masses-in-dogs-18-cases-2009-2014
#3
Melissa A MacIver, J Brad Case, Eric L Monnet, Geraldine B Hunt, Philipp D Mayhew, Michelle L Oblak, Jeffrey J Runge, Ameet Singh, Daniel D Smeak, Michele A Steffey, Sarah E Boston
OBJECTIVE To characterize clinical findings, surgical procedures, complications, and outcomes in dogs undergoing extirpation of masses from the cranial mediastinum via video-assisted thoracic surgery (VATS) and establish preliminary guidelines for case selection when considering VATS for thymectomy in dogs. DESIGN Retrospective case series. ANIMALS 18 client-owned dogs that underwent extirpation of a cranial mediastinal mass by means of VATS at 5 academic referral hospitals from 2009 through 2014. PROCEDURES Medical records were reviewed and data extracted regarding signalment, clinical signs, physical examination findings, diagnostic imaging results, surgical approach and duration, cytologic and histologic examination results, complications, outcome, and cause of death, when applicable...
June 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28502864/chagas-disease-in-europe-a-review-for-the-internist-in-the-globalized-world
#4
REVIEW
Spinello Antinori, Laura Galimberti, Roberto Bianco, Romualdo Grande, Massimo Galli, Mario Corbellino
Chagas disease (CD) or American trypanosomiasis identified in 1909 by Carlos Chagas, has become over the last 40years a global health concern due to the huge migration flows from Latin America to Europe, United States, Canada and Japan. In Europe, most migrants from CD-endemic areas are concentrated in Spain, Italy, France, United Kingdom and Switzerland. Pooled seroprevalence studies conducted in Europe show an overall 4.2% prevalence, with the highest infection rates observed among individuals from Bolivia (18...
May 11, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28375484/mutational-profile-of-tp53-in-esophageal-squamous-cell-carcinoma-associated-with-chagasic-megaesophagus
#5
C F Lacerda, A Cruvinel-Carloni, A T Torres de Oliveira, C Scapulatempo-Neto, R V M López, E Crema, S J Adad, M A M Rodrigues, M A C A Henry, D P Guimarães, R M Reis
Chaga's disease is an important communicable neglected disease that is gaining wider attention due to its increasing incidence worldwide. Achalasia due to chagasic megaesophagus (CM), a complication of this disease, is a known-yet, poorly understood-etiological factor for esophageal squamous cell carcinoma (ESCC) development. In this study, we aimed to perform the analysis of TP53 mutations in a series of Brazilian patients with ESCC that developed in the context CM (ESCC/CM), and to compare with the TP53 mutation profile of patients with benign CM and patients with nonchagasic ESCC...
April 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28375440/high-resolution-manometry-findings-in-patients-with-achalasia-and-massive-dilated-megaesophagus
#6
M A Menezes, C Andolfi, F A M Herbella, M G Patti
Achalasia may present in a non-advanced or an advanced (end stage) stage based on the degree of esophageal dilatation. Manometric parameters and esophageal caliber may be prognostic for the outcome of treatment. The correlation between manometry and disease stage has not been yet fully studied. This study aims to describe high-resolution manometry findings in patients with achalasia and massive dilated megaesophagus. Eighteen patients (mean age 61 years, 55% females) with achalasia and massive dilated megaesophagus, as defined by a maximum esophageal dilatation >10 cm at the barium esophagram, were studied...
May 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28327800/trypanosoma-cruzi-i-genotype-among-isolates-from-patients-with-chronic-chagas-disease-followed-at-the-evandro-chagas-national-institute-of-infectious-diseases-fiocruz-brazil
#7
Tatiana da Silva Fonseca de Oliveira, Barbara Neves Dos Santos, Tainah Silva Galdino, Alejandro Marcel Hasslocher-Moreno, Otilio Machado Pereira Bastos, Maria Auxiliadora de Sousa
INTRODUCTION: Trypanosoma cruzi is the etiologic agent of Chagas disease in humans, mainly in Latin America. Trypanosome stocks were isolated by hemoculture from patients followed at Evandro Chagas National Institute of Infectious Diseases (FIOCRUZ) and studied using different approaches. METHODS: For species and genotype identification, the stocks were analyzed by parasitological techniques, polymerase chain reaction assays targeted to specific DNA sequences, isoenzyme patterns, besides sequencing of a polymorphic locus of TcSC5D gene (one stock)...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28285728/chagas-disease-an-important-cause-of-megaesophagus-in-latin-america
#8
Edson Marchiori, Bruno Hochhegger, Gláucia Zanetti
No abstract text is available yet for this article.
March 9, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28100930/radiological-findings-in-megaesophagus-secondary-to-chagas-disease-chest-x-ray-and-esophagogram
#9
Thiago Giansante Abud, Lucas Giansante Abud, Vanessa Sales Vilar, Denis Szejnfeld, Samuel Reibscheid
OBJECTIVE: To identify and classify the radiographic patterns of megaesophagus in Chagas disease, as seen on esophagograms and chest X-rays. MATERIALS AND METHODS: This was a prospective study of 35 patients diagnosed with esophageal disease via manometry. The changes found on esophagograms were stratified according to Rezende's classification, divided into four categories (grades I through IV) determined by the degree of dilatation and impairement of esophageal motility...
November 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27853047/long-term-management-of-a-dog-with-idiopathic-megaesophagus-and-recurrent-aspiration-pneumonia-by-use-of-an-indwelling-esophagostomy-tube-for-suction-of-esophageal-content-and-esophagogastric-tube-feeding
#10
Yuka Kanemoto, Kenjiro Fukushima, Hideyuki Kanemoto, Koichi Ohno, Hajime Tsujimoto
A 10-year-old neutered male Labrador Retriever dog was diagnosed with idiopathic megaesophagus. Despite receiving conventional treatments including elevated feeding, the dog showed repeated regurgitation and aspiration pneumonia, consequently developing weight loss and severe malnutrition. For the purpose of controlling regurgitation, an esophagostomy tube was placed for draining the esophageal fluid. Additionally, an esophagogastric tube was placed for nutritional support. After tube placement, the average frequency of regurgitation was reduced from 2...
January 24, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27714664/megaesophagus-in-an-elderly-man-with-achalasia-a-not-so-benign-condition
#11
Paolo Mazzola, Francesca Carissimi, Patrizia Floris, Francesca Pittella, Marianna Galeazzi, Daniela Moretti, Giuseppe Bellelli, Marco Dinelli, Giorgio Annoni
No abstract text is available yet for this article.
October 6, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27706452/early-and-late-assessment-of-esophagocardioplasty-in-the-surgical-treatment-of-advanced-recurrent-megaesophagus
#12
José Luis Braga de Aquino, Marcelo Manzano Said, Douglas Alexandre Rizzanti Pereira, Vânia Aparecida Leandro-Merhi, Paula Casals do Nascimento, Virgínia Vieitez Reis
Background: Since Chagas disease has esophageal manifestations with different degrees of involvement, the best surgical option is controversial, especially for patients with advanced chagasic megaesophagus and recurrent symptoms after previous treatment. Objective: To assess the early and late outcomes of esophagocardioplasty in a series of patients with advanced recurrent chagasic megaesophagus. Methods: This descriptive study included 19 older patients with recurrent megaesophagus grade III/IV and positive immunofluorescence for Chagas disease...
October 2016: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/27574362/letter-to-the-editor-more-on-achalasia-with-megaesophagus
#13
Cheng Shen, Guowei Che
No abstract text is available yet for this article.
August 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27566333/abo-secretor-and-lewis-histo-blood-group-systems-influence-the-digestive-form-of-chagas-disease
#14
Cássia Rubia Bernardo, Ana Vitória Silveira Camargo, Luís Sérgio Ronchi, Amanda Priscila de Oliveira, Eumildo de Campos Júnior, Aldenis Albaneze Borim, Cinara Cássia Brandão de Mattos, Reinaldo Bulgarelli Bestetti, Luiz Carlos de Mattos
Chagas disease, caused by Trypanosoma cruzi, can affect the heart, esophagus and colon. The reasons that some patients develop different clinical forms or remain asymptomatic are unclear. It is believed that tissue immunogenetic markers influence the tropism of T. cruzi for different organs. ABO, Secretor and Lewis histo-blood group systems express a variety of tissue carbohydrate antigens that influence the susceptibility or resistance to diseases. This study aimed to examine the association of ABO, secretor and Lewis histo-blood systems with the clinical forms of Chagas disease...
August 24, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27398682/video-assisted-thoracoscopic-resection-of-a-noninvasive-thymoma-in-a-cat-with-myasthenia-gravis-using-low-pressure-carbon-dioxide-insufflation
#15
Maureen A Griffin, Jessie S Sutton, Geraldine B Hunt, Bruno H Pypendop, Philipp D Mayhew
OBJECTIVE: To report the use of low-pressure carbon dioxide insufflation during video-assisted thoracoscopic surgery for resection of a noninvasive thymoma in a cat with secondary myasthenia gravis. STUDY DESIGN: Clinical case report. ANIMAL: Client-owned cat. METHODS: An 11-year-old castrated male domestic shorthair cat was examined for generalized weakness, voice change, hypersalivation, hyporexia, vomiting, coughing, and gagging...
November 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27011598/laparoscopic-esophagogastroplasty-in-management-of-megaesophagus-with-axis-deviation
#16
Nilanjan Panda, Nitin Kumar Bansal, Mohon Narsimhan, Ramesh Ardhanari
The results of cardiomyotomy in patients of achalasic megaesophagus with axis deviation are not satisfactory. Usually, an esophagectomy is advocated. We describe the technical details and outcomes of laparoscopic esophagogastroplasty for end-stage achalasia. The patient had end-stage achalasia, characterized by tortuous megaesophagus with axis deviation. The surgery was performed in supine position using four abdominal ports. The steps included mobilization of the gastroesophageal junction and lower intrathoracic esophagus, straightening the pulled intrathoracic esophagus into the abdomen, and a side-side esophagogastroplasty using purple Endo GIA Articulating Tri-Staple load, two firings...
December 2015: Indian Journal of Surgery
https://www.readbyqxmd.com/read/26676495/chagas-disease-morbidity-profile-in-an-endemic-area-of-northeastern-brazil
#17
Cléber de Mesquita Andrade, Antônia Cláudia Jácome da Câmara, Daniela Ferreira Nunes, Paulo Marcos da Matta Guedes, Wogelsanger Oliveira Pereira, Egler Chiari, Rosiane Viana Zuza Diniz, Lúcia Maria da Cunha Galvão
INTRODUCTION: This study evaluated the clinical forms and manifestation severities of Chagas disease among serologically reactive individuals from Western Rio Grande do Norte (Northeastern Brazil). METHODS: This cross-sectional study included 186 adults who were evaluated using electrocardiography, echocardiography, chest radiography, and contrast radiography of the esophagus and colon. A clinical-epidemiological questionnaire was also used. RESULTS: The indeterminate, cardiac, digestive, and cardiodigestive clinical forms of Chagas disease were diagnosed in 51...
November 2015: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/26672871/images-in-clinical-medicine-achalasia-with-megaesophagus
#18
Chinemerem Okwara, David Cangemi
A 63-year-old man with a history of hypothyroidism presented with a 10-year history of dysphagia to solid foods and liquids. He had had worsening of his symptoms for 6 months before presentation, with an associated weight loss of 27 kg (60 lb). An anterior–posterior radiograph of the chest obtained..
December 17, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26648147/esophagectomy-with-gastroplasty-in-advanced-megaesophagus-late-results-of-omeprazole-use
#19
Celso de Castro Pochini, Danilo Gagliardi, Roberto Saad Júnior, Ruy França de Almeida, Paulo Roberto Corsi
OBJECTIVE: To analyze the late results of advanced Chagasic megaesophagus treatment by esophagectomy associated with the use of proton pump inhibitor (omeprazole) as for the incidence of esophagitis and Barrett's esophagus in the remaining stump. METHODS: We studied patients with advanced megaesophagus undergoing esophagectomy and transmediastinal esophagogastroplasty. Patients were divided into three groups: A (20) with esophageal replacement by full stomach, without the use of omeprazole; B (20) with esophageal replacement by full stomach, with omeprazole 40 mg/day introduced after the first postoperative endoscopy and maintained for six years; and C (30) with esophageal replacement by gastric tube with use of omeprazole...
September 2015: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/26635949/pax7-is-required-for-patterning-the-esophageal-musculature
#20
Daisuke Chihara, Anthony I Romer, C Florian Bentzinger, Michael A Rudnicki, Robert S Krauss
BACKGROUND: The mammalian esophageal musculature is unique in that it makes a transition from smooth to skeletal muscle, with most of this process occurring after birth. In order to better understand the mechanisms that control esophageal musculature development, we investigated the roles in this process of the paired box transcription factor, PAX7, a principal regulator of skeletal myogenic progenitor cells. Previous studies showed that Pax7 is important for determining the esophageal muscle composition...
2015: Skeletal Muscle
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